JP3207996B2 - Sunscreen cosmetics - Google Patents
Sunscreen cosmeticsInfo
- Publication number
- JP3207996B2 JP3207996B2 JP01399094A JP1399094A JP3207996B2 JP 3207996 B2 JP3207996 B2 JP 3207996B2 JP 01399094 A JP01399094 A JP 01399094A JP 1399094 A JP1399094 A JP 1399094A JP 3207996 B2 JP3207996 B2 JP 3207996B2
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- skin
- weight
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- sunscreen
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- Prior art date
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Description
【０００１】[0001]
【産業上の利用分野】本発明は、皮膚安全性に優れ、紫
外線による日焼けを防止する効果及び皮膚の保湿機能を
亢進させて荒れ肌を改善する効果を有し、且つ保存安定
性の高い日焼け止め化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has excellent skin safety, has the effect of preventing sunburn due to ultraviolet rays, has the effect of enhancing the moisturizing function of the skin and has the effect of improving rough skin, and has a high storage stability. Related to cosmetics.
【０００２】[0002]
【従来の技術および発明が解決しようとする課題】日焼
けは、太陽光線中の波長が２９０〜３２０ｎｍの中紫外
線（以下、ＵＶ−Ｂと略記する）と３２０〜４００ｎｍ
の近紫外線（以下、ＵＶ−Ａと略記する）により惹起さ
れるが、ＵＶ−Ｂは皮膚に紅斑を惹起し、炎症後黒化を
もたらす。一方ＵＶ−Ａは、ＵＶ−Ｂに比較して、紅斑
惹起力に非常に弱く、実質上紅斑を起こさず皮膚を黒化
する。2. Description of the Related Art Sunburn has a wavelength of 290 to 320 nm in the sun's rays and 320 to 400 nm.
Is caused by near-ultraviolet light (hereinafter abbreviated as UV-A), but UV-B causes erythema on the skin and causes blackening after inflammation. On the other hand, UV-A is very weak in erythema-inducing power as compared with UV-B, and does not substantially cause erythema and darkens the skin.
【０００３】従来より、これらの障害を予防するため、
各種の紫外線吸収剤を配合した日焼け止め化粧料が開発
され、これらに用いられる紫外線吸収剤としては、ｐ−
アミノ安息香酸誘導体、サリチル酸誘導体、ベンゾフェ
ノン誘導体、ケイ皮酸誘導体等の有機系紫外線吸収剤
と、酸化チタン、酸化亜鉛、酸化鉄等の無機顔料が挙げ
られる。[0003] Conventionally, to prevent these disorders,
Sunscreen cosmetics containing various types of ultraviolet absorbers have been developed.
Organic ultraviolet absorbers such as aminobenzoic acid derivatives, salicylic acid derivatives, benzophenone derivatives, and cinnamic acid derivatives; and inorganic pigments such as titanium oxide, zinc oxide, and iron oxide.
【０００４】このような日焼け止め化粧料には、健常な
皮膚を保持する為に、皮膚に適度な水分を与える親水性
の皮膚保湿剤が配合される。[0004] In order to maintain healthy skin, such sunscreen cosmetics are blended with a hydrophilic skin moisturizer that imparts appropriate moisture to the skin.
【０００５】皮膚保湿剤には、グリセリン、プロピレン
グリコール、１，３−ブチレングリコール、ポリエチレ
ングリコール等が利用されているが、これを含有する日
焼け止め化粧料においては、紫外線の皮膚への透過を促
進させるので、十分な日焼け防止効果を示さないという
欠点を有していた。したがって、一定の日焼け止め効果
を達成するためには、大量の紫外線吸収剤の配合が必要
となり、その結果、皮膚安全性に問題が生じることが多
い。さらに、これらの皮膚保湿剤は皮膚の最外層である
角質層の水分を吸収して、かえって皮膚の水分を損失す
る原因となり、荒れ肌がもたらされてしまうこともあ
る。Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and the like are used as skin moisturizers. Sunscreen cosmetics containing the same promote the penetration of ultraviolet rays into the skin. Therefore, there is a drawback that a sufficient sun protection effect is not exhibited. Therefore, in order to achieve a certain sunscreen effect, it is necessary to add a large amount of an ultraviolet absorber, and as a result, there is often a problem in skin safety. Furthermore, these skin moisturizers absorb the water of the stratum corneum, which is the outermost layer of the skin, and rather cause the loss of the water of the skin, sometimes leading to rough skin.
【０００６】本発明者らはこのような事実に鑑み鋭意検
討を重ねた結果、後記日焼け止め化粧料が、皮膚安全性
に優れ、紫外線による日焼けを防止する効果、皮膚の保
湿機能を亢進させて荒れ肌を改善する効果を有し、且つ
保存安定性も高いことを見出し、本発明を完成するに至
った。The inventors of the present invention have conducted intensive studies in view of the above facts. As a result, the sunscreen cosmetics described below have excellent skin safety, an effect of preventing sunburn due to ultraviolet rays, and an enhancement of the moisturizing function of the skin. The present inventors have found that they have an effect of improving rough skin and have high storage stability, and have completed the present invention.
【０００７】本発明の目的は、皮膚安全性に優れ、紫外
線による日焼けを防止する効果と皮膚の保湿機能を亢進
させ荒れ肌を改善する効果に優れ、且つ保存安定性の高
い日焼け止め化粧料を提供することにある。An object of the present invention is to provide a sunscreen cosmetic which is excellent in skin safety, has an effect of preventing sunburn due to ultraviolet rays, has an excellent effect of enhancing the moisturizing function of the skin and improves rough skin, and has high storage stability. Is to do.
【０００８】[0008]
【課題を解決するための手段】上記目的を達成する本発
明は、セラミド、グルコシルセラミド、ガラクトシルセ
ラミドより選ばれた少なくとも一種と水溶性紫外線吸収
剤とを含有することを特徴とする日焼け止め化粧料であ
り、好ましい態様としては、セラミド、グルコシルセラ
ミド、ガラクトシルセラミドの含有量が日焼け止め化粧
料全量に対して０．００５〜３．０重量％であり、水溶
性紫外線吸収剤の含有量が日焼け止め化粧料全量に対し
て０．５〜２０重量％であることを特徴とする日焼け止
め化粧料である。さらに好ましい態様としては、創傷治
癒剤，新陳代謝促進剤，抗炎症剤のうち少なくとも一種
を併用することを特徴とする日焼け止め化粧料である。The present invention, which achieves the above object, provides a sunscreen cosmetic comprising at least one selected from ceramide, glucosylceramide and galactosylceramide and a water-soluble ultraviolet absorber. In a preferred embodiment, the content of ceramide, glucosylceramide and galactosylceramide is 0.005 to 3.0% by weight based on the total amount of the sunscreen cosmetic, and the content of the water-soluble ultraviolet absorber is sunscreen. It is a sunscreen cosmetic characterized by being 0.5 to 20% by weight based on the total amount of the cosmetic. A further preferred embodiment is a sunscreen cosmetic characterized by using at least one of a wound healing agent, a metabolic accelerator, and an anti-inflammatory agent.
【０００９】以下、本発明の構成について詳述する。本
発明の日焼け止め化粧料に用いられるセラミド、グルコ
シルセラミド、ガラクトシルセラミドは、例えば、以下
の方法で得ることができる。即ち、原料となる牛脳を細
切後、アセトンを添加しポリトロンにてホモジネートを
調節した。不溶物を濾別後、クロロホルム：メタノール
（２：１、容積比、以下も同様）を添加、一夜放置後、
抽出液を減圧乾固した。ついで、冷アセトンに抽出液を
懸濁させ、４℃で一夜放置後、沈渣を得た。冷エーテル
にて同様の操作で沈渣を得た。ケイ酸カラムクロマトグ
ラフィー（クロロホルム：メタノール＝２：１）により
ガラクトシルセラミドを分離して得た。Hereinafter, the configuration of the present invention will be described in detail. Ceramide, glucosylceramide and galactosylceramide used in the sunscreen cosmetic of the present invention can be obtained, for example, by the following method. That is, after the bovine brain as a raw material was minced, acetone was added, and the homogenate was adjusted with a polytron. After filtering off the insoluble matter, chloroform: methanol (2: 1, volume ratio, the same applies to the following) was added.
The extract was dried under reduced pressure. Then, the extract was suspended in cold acetone and left at 4 ° C. overnight to obtain a precipitate. A precipitate was obtained by the same operation using cold ether. Galactosylceramide was obtained by separation by silica column chromatography (chloroform: methanol = 2: 1).
【００１０】上記中、牛脳を牛脾臓に変え、全く同様に
してグルコシルセラミドを得た。In the above, the bovine brain was changed to bovine spleen, and glucosylceramide was obtained in exactly the same manner.
【００１１】上記中、ガラクトシルセラミドを分離後溶
媒をクロロホルム：メタノール（１：１）にすることに
よってスフィンゴミエリンを得た。これをエーテル：エ
タノール（９８：２）に溶解後、１００ｍＭトリス塩酸
緩衝液及びホスホリパーゼＣ（シグマ社製）を加え、３
０℃で３時間振盪した。その後クロロホルム：メタノー
ル（２：１）を添加してから、攪拌、遠心し、下層を減
圧下で乾固した。得られた乾固物のケイ酸カラムクロマ
トグラフィー（クロロホルム：メタノール＝９：１）に
よりセラミドを分離して得た。After separating galactosylceramide from the above, sphingomyelin was obtained by changing the solvent to chloroform: methanol (1: 1). This was dissolved in ether: ethanol (98: 2), and 100 mM Tris-HCl buffer and phospholipase C (manufactured by Sigma) were added.
Shake at 0 ° C. for 3 hours. Thereafter, chloroform: methanol (2: 1) was added thereto, followed by stirring and centrifugation, and the lower layer was dried under reduced pressure. Ceramide was obtained by separating ceramide by silica column chromatography (chloroform: methanol = 9: 1) of the obtained dried product.
【００１２】また、本発明の日焼け止め化粧料に用いら
れる水溶性紫外線吸収剤としては、パラアミノ安息香
酸、パラメトキシ桂皮酸、２−フェニルベンズイミダゾ
ル−５−スルホン酸、及びサリチル酸誘導体のアルカリ
金属、アンモニア、又は有機アミンの各塩などが挙げら
れるがこれらに限定されるものではない。これらの水溶
性紫外線吸収剤は１種又は２種以上を混合して用いられ
る。The water-soluble ultraviolet absorbers used in the sunscreen cosmetics of the present invention include para-aminobenzoic acid, para-methoxycinnamic acid, 2-phenylbenzimidazole-5-sulfonic acid, and alkali metals of salicylic acid derivatives, Examples include, but are not limited to, ammonia and salts of organic amines. These water-soluble ultraviolet absorbers are used alone or in combination of two or more.
【００１３】セラミド、グルコシルセラミド及びガラク
トシルセラミドの配合量は、本発明の日焼け止め化粧料
の全量を基準としてそれぞれ０．００５〜３．０重量％
が特に好ましく、さらに一段と好ましい効果が得られる
のは０．０５〜２．０重量％の範囲内である。０．００
５重量％未満において、効果が発現しないわけではない
が、十分に高い効果とは言えない。一方、３．０重量％
を超えるとき、効果が発現しないわけではないが、製品
の保存安定性に劣るのでやや好ましくない。The amount of ceramide, glucosylceramide and galactosylceramide is 0.005 to 3.0% by weight based on the total amount of the sunscreen cosmetic of the present invention.
Is particularly preferable, and the more preferable effect is obtained in the range of 0.05 to 2.0% by weight. 0.00
When the amount is less than 5% by weight, the effect is not necessarily not exhibited, but it cannot be said that the effect is sufficiently high. On the other hand, 3.0% by weight
When the value exceeds, the effect is not necessarily not exhibited, but it is slightly undesirable because the storage stability of the product is inferior.
【００１４】水溶性紫外線吸収剤の配合量は、本発明の
日焼け止め化粧料の全量を基準として０．５〜２０重量
％が特に好ましく、さらに一段と好ましい効果が得られ
るのは１．０〜１０重量％である。０．５重量％未満に
おいて、効果が発現しないわけではないが、十分に高い
紫外線防止効果が得られない。一方、２０重量％を超え
るとき、十分に高い紫外線防止効果が得られるが、使用
時の感触が悪くなり易く、個々の剤型を保持し難くなる
のでやや好ましくない。The blending amount of the water-soluble ultraviolet absorber is particularly preferably 0.5 to 20% by weight based on the total amount of the sunscreen cosmetic of the present invention, and more preferably 1.0 to 10% by weight. % By weight. If the amount is less than 0.5% by weight, the effect is not necessarily not exhibited, but a sufficiently high ultraviolet ray preventing effect cannot be obtained. On the other hand, when it exceeds 20% by weight, a sufficiently high ultraviolet ray preventing effect can be obtained, but the feeling at the time of use is apt to deteriorate and it is difficult to hold individual dosage forms, which is slightly unpreferable.
【００１５】本発明の日焼け止め化粧料には、創傷治癒
剤、新陳代謝促進剤、抗炎症剤のうち少なくとも一種を
併用することによって皮膚安全性に優れ、紫外線による
日焼けを防止する効果と皮膚の保湿機能を亢進させて荒
れ肌を改善する効果を高めることができる。The sunscreen cosmetic of the present invention is excellent in skin safety by using at least one of a wound healing agent, a metabolic accelerator, and an anti-inflammatory agent, has an effect of preventing sunburn by ultraviolet rays, and has an effect of moisturizing the skin. The effect of enhancing the function and improving the rough skin can be enhanced.
【００１６】以下に、併用成分について説明する。創傷
治癒剤とは、当帰エキス、アラントイン、又はその誘導
体、ローズマリー抽出物である。新陳代謝促進剤とは、
胎盤抽出物（水溶性プラセンタエキス）、γ−オリザノ
ール、各種アミノ酸、ビタミンＥ又はその誘導体であ
る。抗炎症剤とは、グリチルリチン酸又はその誘導体、
アロエ抽出物、マロニエ抽出物である。Hereinafter, the combined components will be described. The wound healing agent is a tomato extract, allantoin or a derivative thereof, or a rosemary extract. What are metabolic accelerators?
Placenta extract (water-soluble placenta extract), γ-oryzanol, various amino acids, vitamin E or derivatives thereof. Anti-inflammatory agent, glycyrrhizic acid or a derivative thereof,
It is an aloe extract and a horse chestnut extract.
【００１７】本発明の日焼け止め化粧料には、上記成分
の他にパラアミノ安息香酸、パラメトキシ桂皮酸、２−
フェニルベンズイミダゾル−５−スルホン酸、サリチル
酸誘導体等の油溶性紫外線吸収剤、タール系色素、酸化
鉄などの着色顔料、パラベンなどの防腐剤、脂肪酸セッ
ケン、セチル硫酸ナトリウム、Ｎ−ステアロイル−Ｌ−
グルタミン酸ナトリウムなどの陰イオン界面活性剤、ポ
リオキシエチレンアルキルエーテル、ポリオキシエチレ
ン脂肪酸エステル、ポリオキシエチレン多価アルコール
脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、多
価アルコール脂肪酸エステル、ポリグリセリン脂肪酸エ
ステルなどの非イオン界面活性剤、テトラアルキルアン
モニウム塩などの陽イオン界面活性剤、ベタイン型、ス
ルホベタイン型、スルホアミノ酸型などの両性界面活性
剤、レシチン、リゾレシチンなどの天然系界面活性剤、
酸化チタンなどの顔料、ジブチルヒドロキシトルエンな
どの抗酸化剤などを、本発明の目的を達成する範囲内で
適宜配合することができる。The sunscreen cosmetic of the present invention contains, in addition to the above components, paraaminobenzoic acid, paramethoxycinnamic acid,
Oil-soluble ultraviolet absorbers such as phenylbenzimidazole-5-sulfonic acid and salicylic acid derivatives, tar pigments, coloring pigments such as iron oxide, preservatives such as paraben, fatty acid soap, sodium cetyl sulfate, N-stearoyl-L-
Anionic surfactants such as sodium glutamate, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, etc. Nonionic surfactants, cationic surfactants such as tetraalkylammonium salts, betaine type, sulfobetaine type, amphoteric surfactants such as sulfoamino acid type, natural surfactants such as lecithin and lysolecithin,
A pigment such as titanium oxide, an antioxidant such as dibutylhydroxytoluene, and the like can be appropriately compounded as long as the object of the present invention is achieved.
【００１８】本発明の化粧料の剤型としては、クリー
ム、乳液、化粧水などが挙げられる。この化粧料は、例
えば乳液等の場合、油相及び水相をそれぞれ加熱溶解し
たものを乳化分散して冷却する通常の方法により製造す
ることができる。Examples of the dosage form of the cosmetic of the present invention include creams, emulsions, and lotions. For example, in the case of an emulsion or the like, this cosmetic can be produced by a usual method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, and cooling.
【００１９】[0019]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳述する。なお、実施例に示す％とは重量％である。実
施例に記載の（１）保存安定性試験法、（２）光パッチ
試験、（３）荒れ肌改善効果の測定試験法、（４）紫外
線防御能測定法はそれぞれ下記のとおりである。The present invention will be described below in detail based on examples and comparative examples. The percentages shown in the examples are percentages by weight. (1) Storage stability test method, (2) light patch test, (3) measurement test method for improving rough skin, and (4) UV protection ability measurement method described in Examples are as follows.
【００２０】（１）保存安定性試験法 試料を４５℃の恒温槽に入れて経日観察を行い、下記の
判定基準に従って評価した。 保存安定性試験の判定基準 １０日間で異常が認められる場合 × １ケ月で異常が認められる場合 △ ３ケ月で異常が認められる場合 ○ ４ケ月で異常が認められない場合 ◎ ここで異常とは、変色・変臭が生じる、化粧水で沈殿が
生じる、乳化物で相分離が生じる現象を意味する。(1) Storage stability test method Samples were placed in a thermostat at 45 ° C. and observed over time, and evaluated according to the following criteria. Judgment criteria for storage stability test When abnormalities are observed in 10 days × When abnormalities are observed in 1 month △ When abnormalities are observed in 3 months ○ When no abnormalities are observed in 4 months ◎ Here, abnormalities It means the phenomenon of discoloration / odor change, precipitation in lotion, and phase separation in emulsion.
【００２１】（２）光パッチ試験 被験者２５名の前腕屈側部皮膚に試料０．０５ｇを塗布
した直径１．０ｃｍのパッチ板を用いて２４時間クロー
ズドパッチを行った後、夏期の太陽光を６時間（１日３
時間で２日間）照射した。(2) Optical Patch Test Closed patching was performed for 24 hours using a 1.0 cm diameter patch plate on which 0.05 g of a sample was applied to the skin of the flexion side of the forearm of 25 subjects. 6 hours (3 days a day)
Irradiation for 2 days).
【００２２】評価は、下記の判定基準に従い、被験者２
５名の皮膚の状態を評価判定した。判定結果は、照射２
４時間後に、（±）以上の人数で示した。 判定基準 紅斑・浮腫・水泡 （＋＋＋） 紅斑・浮腫 （＋＋） 紅斑 （＋） 軽微な紅斑 （±） 無紅斑 （−）The evaluation was performed according to the following criteria.
The skin condition of five persons was evaluated and evaluated. The judgment result is irradiation 2
Four hours later, the number was indicated by (±) or more. Judgment criteria Erythema / edema / water bubbles (++) Erythema / edema (++) Erythema (+) Minor erythema (±) No erythema (-)
【００２３】（３）荒れ肌改善効果の測定試験法 下脚に荒れ肌を有する中高年被験者２０名を対象として
４週間連続塗布効果を調べた。被験者の左側下脚試験部
位に１日２回約１ｇの試料を塗布し、試験開始前および
終了後の皮膚の状態を下記の判定基準により判定した。
右側下脚は試料を塗布せず対照とした。 皮膚乾燥度の判定基準 − ：正常 ± ：軽微乾燥、落屑なし ＋ ：乾燥、落屑軽度 ＋＋ ：乾燥、落屑中程度 ＋＋＋：乾燥、落屑顕著 試験前後の試験部位と対照部位の判定結果を比較して、
皮膚乾燥度が２段階以上改善された場合（例えば；＋→
−、＋＋→±）を「有効」、１段階改善された場合を
「やや有効」、変化がなかった場合を「無効」とした。
試験結果は「有効」、「やや有効」となった被験者の人
数で示した。(3) Measurement Test Method for Improvement of Rough Skin The effect of continuous application for four weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of the sample was applied to the test site of the left lower leg of the subject twice a day, and the condition of the skin before and after the start of the test was determined according to the following criteria.
The lower right leg served as a control without the application of the sample. Judgment criteria for skin dryness-: Normal ±: Slightly dry, no desquamation +: Dry, desquamation slightly ++: Dry, moderate desquamation +++: Dry, desquamation remarkable Compare the test results before and after the test with the control site ,
When the degree of dryness of the skin is improved by two or more stages (for example; + →
−, ++ → ±) were regarded as “valid”, the case where the signal was improved by one stage was “slightly valid”, and the case where there was no change was “invalid”.
The test results were indicated by the number of subjects who became “effective” and “slightly effective”.
【００２４】（４）紫外線防御能測定法 被験者１０人の背中を使用して試験する。あらかじめ、
試料無塗布の状態で最小紅斑惹起紫外線量（以下ＭＥＤ
とする）を測定した。光源は、ＳｏｌａｒＵｌｔｒａｖ
ｉｏｌｅｔ Ｓｉｍｕｌａｔｏｒ Ｍｏｄｅｌ ６００
（Ｓｏｌａｒ Ｌｉｇｈｔ Ｃｏ．製）を用いた。被験
者背部に各試料を２ｍｇ／ｃｍ2 塗布し、同様に試料塗
布部位のＭＥＤを測定した。試料塗布部ＭＥＤの試料無
塗布部ＭＥＤに対する比を求め、サンプロテクションフ
ァクター（以下ＳＰＦとする）とした。試験結果は、Ｓ
ＰＦの平均値で示した。(4) Measurement method of ultraviolet protection ability The test is carried out using the backs of 10 subjects. in advance,
The minimum amount of erythema-inducing ultraviolet radiation (hereinafter MED)
) Was measured. The light source is SolarUltrav
iolet Simulator Model 600
(Manufactured by Solar Light Co.). Each sample was applied to the back of the subject at 2 mg / cm 2 , and the MED at the sample application site was measured in the same manner. The ratio of the sample applied area MED to the sample non-applied area MED was determined and defined as a sun protection factor (hereinafter referred to as SPF). The test result is S
The average value of PF was shown.
【００２５】実施例１〜６、比較例１〜３［日焼け止め
クリーム］ セラミド、グルコシルセラミド、ガラクトシルセラミド
類と水溶性紫外線吸収剤を表１の組成において配合し、
下記の調製方法に基づいて日焼け止めクリームを調製し
た。各々について前記の諸試験を実施し、その結果を表
２に示した。 組成Examples 1 to 6, Comparative Examples 1 to 3 [Sunscreen cream] Ceramide, glucosylceramide, galactosylceramides and a water-soluble ultraviolet absorber were blended in the composition shown in Table 1,
A sun cream was prepared based on the following preparation method. Each of the above tests was performed for each, and the results are shown in Table 2. composition
【００２６】[0026]
【表１】 [Table 1]
【００２７】[0027]
【表２】 [Table 2]
【００２８】調製方法 （Ｂ）の油溶性成分を（Ａ）に投入して７０℃、（Ｂ）
の水溶性成分を（Ｃ）に投入して５０℃にて均一に溶解
し、（Ａ）を攪拌しながら（Ｃ）を（Ａ）に投入して乳
化分散した後、攪拌しながら温度３０℃まで冷却して調
製する。Preparation Method The oil-soluble component of (B) is added to (A) and the mixture is heated to 70 ° C. and (B)
Is added to (C) and uniformly dissolved at 50 ° C., (A) is stirred while (C) is added to (A) to emulsify and disperse, and then stirred at a temperature of 30 ° C. Prepare by cooling.
【００２９】特性 本発明の実施例１〜６のスキンクリームは、諸特性にお
いて顕著な効果が認められた。一方、比較例１〜３のス
キンクリームは、本発明の実施例に比べて諸特性におい
て劣っていた。Characteristics The skin creams of Examples 1 to 6 of the present invention exhibited remarkable effects in various characteristics. On the other hand, the skin creams of Comparative Examples 1 to 3 were inferior in various properties as compared with the examples of the present invention.
【００３０】実施例７［二層型ローション］ 表３の組成により本発明の二層型ローションを下記の製
法によって調製した。Example 7 [Two-Layer Lotion] A two-layer lotion of the present invention having the composition shown in Table 3 was prepared by the following method.
【００３１】[0031]
【表３】 [Table 3]
【００３２】調製法 （Ａ）、（Ｂ）成分を各々均一に溶解した後、（Ａ）成
分と（Ｂ）成分を混合攪拌分散し、次いで容器に充填す
る。使用時には内容物を均一に振盪分散して使用する。Preparation Method After the components (A) and (B) are uniformly dissolved, the components (A) and (B) are mixed, stirred and dispersed, and then filled in a container. When used, the contents are shaken and dispersed uniformly.
【００３３】特性 この実施例７のスキンローションは、前記諸試験すべて
において良好な結果を示した。Properties The skin lotion of Example 7 showed good results in all of the above tests.
【００３４】実施例８ 表４の組成により本発明のクリームを常法によって調製
した。Example 8 A cream according to the present invention was prepared by a conventional method according to the composition shown in Table 4.
【００３５】[0035]
【表４】 [Table 4]
【００３６】この実施例７のクリームは、前記諸試験す
べてにおいて良好な結果を示した。さらに、グリチルリ
チンジカリウムの代わりに、当帰エキス（３．０重量
％）、アラントイン（０．１重量％）、ローズマリー抽
出物（２．０重量％）、水溶性プラセンタエキス（１．
０重量％）、γ−オリザノール（０．１重量％）、ビタ
ミンＥ又はニコチン酸トコフェロール（０．２重量
％）、アロエ抽出物（３．０重量％）、マロニエ抽出物
（３．０重量％）をそれぞれ配合したクリームも、前記
諸試験すべてにおいて良好な結果を示した。The cream of Example 7 showed good results in all of the above tests. Further, instead of glycyrrhizin dipotassium, Toki extract (3.0% by weight), allantoin (0.1% by weight), rosemary extract (2.0% by weight), water-soluble placenta extract (1.
0% by weight), γ-oryzanol (0.1% by weight), vitamin E or tocopherol nicotinate (0.2% by weight), aloe extract (3.0% by weight), malonie extract (3.0% by weight) ) Also showed good results in all of the above tests.
【００３７】[0037]
【発明の効果】以上記載のごとく、本発明が、優れた日
焼け止め効果と皮膚の保湿機能を亢進させて荒れ肌を改
善する効果及び皮膚安全性に優れ、保存安定性の高い日
焼け止め化粧料を提供することは明らかである。As described above, the present invention provides a sunscreen cosmetic having an excellent sunscreen effect, an effect of enhancing the moisturizing function of the skin to improve rough skin, an excellent skin safety, and a high storage stability. It is clear to offer.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/42 A61K 7/00 A61K 7/48 ──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. 7 , DB name) A61K 7/42 A61K 7/00 A61K 7/48
Claims (4)
トシルセラミドより選ばれた少なくとも一種と水溶性紫
外線吸収剤とを含有することを特徴とする日焼け止め化
粧料。1. A sunscreen cosmetic comprising at least one selected from ceramide, glucosylceramide and galactosylceramide and a water-soluble ultraviolet absorber.
トシルセラミドより選ばれた少なくとも一種を０．００
５〜３．０重量％配合することを特徴とする請求項１記
載の日焼け止め化粧料。2. The method of claim 1, wherein at least one selected from ceramide, glucosylceramide and galactosylceramide is 0.00
The sunscreen cosmetic according to claim 1, wherein the sunscreen cosmetic is incorporated in an amount of 5 to 3.0% by weight.
％配合することを特徴とする請求項１又は２に記載の日
焼け止め化粧料。3. The sunscreen cosmetic according to claim 1, wherein the water-soluble ultraviolet absorber is incorporated in an amount of 0.5 to 20% by weight.
のうち少なくとも一種を併用することを特徴とする請求
項１〜３に記載の日焼け止め化粧料。4. The sunscreen cosmetic according to claim 1, wherein at least one of a wound healing agent, a metabolic accelerator, and an anti-inflammatory agent is used in combination.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP01399094A JP3207996B2 (en) | 1994-01-11 | 1994-01-11 | Sunscreen cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP01399094A JP3207996B2 (en) | 1994-01-11 | 1994-01-11 | Sunscreen cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07206652A JPH07206652A (en) | 1995-08-08 |
| JP3207996B2 true JP3207996B2 (en) | 2001-09-10 |
Family
ID=11848677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP01399094A Expired - Fee Related JP3207996B2 (en) | 1994-01-11 | 1994-01-11 | Sunscreen cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3207996B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001013881A1 (en) * | 1999-08-24 | 2001-03-01 | Kao Corporation | Cosmetics |
| JP6232285B2 (en) * | 2013-12-27 | 2017-11-15 | 花王株式会社 | Cosmetics |
| CN107686451B (en) * | 2017-09-29 | 2020-07-03 | 烟台新时代健康产业日化有限公司 | Preparation method of chestnut skin extract containing ceramide |
| JP2018177819A (en) * | 2018-08-20 | 2018-11-15 | 株式会社東洋新薬 | Composition containing specific component |
-
1994
- 1994-01-11 JP JP01399094A patent/JP3207996B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07206652A (en) | 1995-08-08 |
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