CN110327438A - One kind is releived massage cream - Google Patents

One kind is releived massage cream Download PDF

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Publication number
CN110327438A
CN110327438A CN201910659925.XA CN201910659925A CN110327438A CN 110327438 A CN110327438 A CN 110327438A CN 201910659925 A CN201910659925 A CN 201910659925A CN 110327438 A CN110327438 A CN 110327438A
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CN
China
Prior art keywords
releiving
massage cream
extract
parts
oil
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CN201910659925.XA
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Chinese (zh)
Inventor
李凤艳
谢金嫦
林锦雄
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Guangzhou I & B Biological Technology Co Ltd
Guangzhou Aibei Biological Technology Co Ltd
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Guangzhou I & B Biological Technology Co Ltd
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Priority to CN201910659925.XA priority Critical patent/CN110327438A/en
Publication of CN110327438A publication Critical patent/CN110327438A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

It releives massage cream the invention discloses one kind, it contains the following parts by weight: 0.1~3 part of lovage root oil, 0.1~2 part of cardamon seed oil, 0.1~2 part of cnidium oil, 0.01~1 part of safflower seed oil, 0.05~2.25 part and 0.025~1.5 part of 4- tert. butyl cyclohexanol of 1,2- pentanediol.The effect of massage cream of the present invention of releiving can releive skin, play activating microcirculation and removing stasis medicinal, promote blood circulation, and improve cold body, remove rheumatism.

Description

One kind is releived massage cream
Technical field
The present invention relates to a kind of massage creams, and in particular to a kind of massage cream of releiving containing traditional Chinese medicine ingredients.
Background technique
Massage cream is a kind of lotion of combination physical massage, is used by massage.Massage cream has lubrication and cleaning skin Effect serves as important medium in massage processes.Cooperate correct massage method that can releive body and mind, regain one's strength, mitigate it is tired Labor, enhancing blood circulation, beauty diseases prevention.Now similar product majority is invigorated blood circulation only with thermal sensation on the market, has promoting blood circulationization of releiving The massage cream type of the benefits of stasis of blood is less.
Summary of the invention
One kind is provided it is an object of the invention to overcome in place of the shortcomings of the prior art to releive massage cream.
To achieve the above object, the technical scheme adopted by the invention is as follows: one kind is releived massage cream, and following parts by weight are included Component: 0.1~3 part of lovage root oil, 0.1~2 part of cardamon seed oil, 0.1~2 part of cnidium oil, safflower seed oil 0.01~1 Part, 0.05~2.25 part of 1,2- pentanediol and 0.025~1.5 part of 4- tert. butyl cyclohexanol.
Radix Angelicae Sinensis, sweet in flavor, slight bitter is strongly fragrant, there is wine aroma.Containing there are many volatile oil components.Complicated component, grease, acid Class, sterols all contain.For skin, there is good wettability effect, based on Radix Angelicae Sinensis activating microcirculation and removing stasis medicinal, improves that skin is micro- follows The effect of ring, Radix Angelicae Sinensis show that it is invigorating blood circulation simultaneously to the proliferation of blood vessel chrotoplast, play the role of solidifying capillary；Radix Angelicae Sinensis has Good SOD sample activity, inhibits the reaction of membrane lipid peroxidatio caused by superoxide radical and radical reaction, and and biomembrane Damage of a variety of mechanism antagonism free radicals such as phosphatide join protection membrane lipid to tissue, it is gloomy to complexion caused by free radical retardance Or raw sore swells, there is special efficacy；Activation rate to luciferase and the proliferation function to stem cell show Antiageing effect.
Cardamom (ELETTARIA CARDAMOMUM) seed oil has the function of moisturizing, nourishes rough skin, is good moisturizing Agent；Cardamon seed and its extract are the common edible flavor material in South Asia and Southeast Asia and antibacterial agent and anti-mite agent.Fluorescein Enzymatic activity is low, illustrates that the easy inflammation specific skin of skin, cardamon seed extract are aobvious to the activation of uciferase activity etc. Show, it has anti-inflammatory；Extract can enhance activity of aromatizing enzyme, be conducive to the generation for inhibiting local fat group, have weight-reducing to make With.
Rhizoma Chuanxiong (LIGUSTICUM CHUANXIONG) oil can eliminate free radical, have oxidation resistant effect, prevent aging； Melanocyte activity can be effectively suppressed in the Rhizoma Chuanxiong of low concentration, reduces melanin, has a white-skinned face function, but excessive concentration When, show cytotoxicity；Have the effect of moisturizing, anti-inflammatory and weight-reducing simultaneously.
Safflower (CARTHAMUS TINCTORIUS) seed oil is rich in linolenic acid, fat with substance (vitamin E, dimension life Plain A), it is contacted with air perishable.Eczema and rough skin can be improved, so that skin is become water tender smooth, help new old generation Thank to normalization.
1,2- pentanediol and 4- tert. butyl cyclohexanol are capable of the neural sensation activity of rapid recovery sensitivity skin symptom, hence it is evident that Mitigate burning sensation and tingling sensation；Alleviate the overreaction of skin, reduces condition susceptible.
Massage cream of the present invention is added to the lovage root oil of said ratio, cardamon seed oil, cnidium oil, kardiseed Oil, 1,2- pentanediol and 4- tert. butyl cyclohexanol, can releive skin, play activating microcirculation and removing stasis medicinal, promote blood circulation, and improve body It is cold, the effect of remove rheumatism.
Preferably, the massage cream of releiving also contains the following parts by weight: 0.1~2 part of vanillyl butyl ether, race Oily 0.1~3 part, 0.1~3 part of extract of capsicum (CAPSICUM ANNUUM).
Vanillyl butyl ether can quickly generate mild lasting pyrogenic effect, including accelerate microcirculation, stimulate subcutaneous fat Metabolism promotes capillary blood circulation etc..Ginger (ZINGIBER OFFICINALE) root oil can enhance the activity of skin, activate flesh Skin.1,2- pentanediol and 4- tert. butyl cyclohexanol are capable of the neural sensation activity of rapid recovery sensitivity skin symptom, hence it is evident that mitigate Burning sensation and tingling sensation；Alleviate the overreaction of skin, reduces condition susceptible.Vanillyl butyl ether, ginger oil and capsicum are extracted Object three can cooperate, and quickly generate mild lasting pyrogenic effect, accelerate skin microcirculation, promote skin to effect at The absorption divided, plays the Transdermal absorption effect of collaboration.
Preferably, the massage cream of releiving also contains the following parts by weight: 0.2~0.8 part of vanillyl butyl ether, ginger 1.2~2.4 parts of root oil, 0.2~0.8 part of pepper extract.Under said ratio, skin can be advantageously promoted to effective component Absorption.
Preferably, the massage cream of releiving also contains the following parts by weight: 0.5 part of vanillyl butyl ether, ginger oil 1.8 parts, 0.5 part of pepper extract.Same additive amount, under said ratio, the promotion assimilation effect being able to achieve is best.
Preferably, the massage cream of releiving contains the following parts by weight: 1 part of lovage root oil, cardamon seed oil 0.5 part, 0.8 part of cnidium oil, 0.1 part of safflower seed oil, 0.4~0.6 part of 1,2- pentanediol and 4- tert. butyl cyclohexanol 0.2~0.4 Part.
Preferably, the massage cream of releiving also includes zedoary (CURCUMA PHAEOCAULIS) extract, ginger (ZINGIBER OFFICINALE) root extract, Rhizoma Et Radix Notopterygii (NOTOPTERYGIUM INCISUM) extract, radix saposhnikoviae 0.5~3 parts by weight of mixture of (SAPOSHNIKOVIA DIVARICATA) extract and hydrogenation Sweet Almond Oil.
In said mixture, the weight ratio of each ingredient are as follows: zedoary extract: ginger-root extract: notopterygium root extract: anti- Wind extract: hydrogenation Sweet Almond Oil=15~25:15~25:10~20:15~25:45~50.
It is highly preferred that the massage cream of releiving also includes zedoary extract, ginger-root extract, notopterygium root extract, radix saposhnikoviae 2 parts by weight of mixture of extract and hydrogenation Sweet Almond Oil.
Preferably, the massage cream of releiving also includes that Radix Angelicae Sinensis (ANGELICA POLYMORPHA SINENSIS) root extracts Object, Radix Notoginseng (PANAX NOTOGINSENG) root extract, Astragalus membranacus (ASTRAGALUS MEMBRANACEUS) root extract, The mixture of glossy privet (LIGUSTRUM LUCIDUM) seed extract, Radix Glycyrrhizae (GLYCYRRHIZA URALENSIS) root extract 0.035~0.7 part.
Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet seed extract, licorice root extract Weight ratio are as follows: 1~2:1~2:0.5~1:0.5~1:0.5~1.
The massage cream of releiving of mentioned component is added to according to " monarch, minister, the help, make " principles of formulating prescriptions, with Radix Angelicae Sinensis, Radix Notoginseng, fluffy cowherb Art is monarch drug in a prescription, blood circulation promoting and enriching, hemostasis stasis function；Using Radix Astragali, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, ginger as ministerial drug, invigorating qi for consolidating superficies is played, wind-dispelling stops Bitterly, the benefits of promoting normal circulation of qi and blood；It is assistant with the fruit of glossy privet, cardamom, safflower, expels pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion, relieving convulsion； It, can coordinating the drug actions of a prescription pharmacological property with Radix Glycyrrhizae, radix saposhnikoviae to make.The principles of formulating prescriptions of design considerations " monarch " are formulated, there is ingredients The effect of machine compounding, plays activating microcirculation and removing stasis medicinal, promotes blood circulation, improvement cold body, remove rheumatism.It is micro- that long-time service can promote skin Circulation, significantly improves elasticity of skin and glossiness.
It is highly preferred that the massage cream of releiving also includes that Radix Angelicae Sinensis (ANGELICA POLYMORPHA SINENSIS) root extracts Object, Radix Notoginseng (PANAX NOTOGINSENG) root extract, Astragalus membranacus (ASTRAGALUS MEMBRANACEUS) root extract, The mixture of glossy privet (LIGUSTRUM LUCIDUM) seed extract, Radix Glycyrrhizae (GLYCYRRHIZA URALENSIS) root extract 0.14~0.28 part.
Preferably, the massage cream of releiving also contains the following parts by weight: 2~8 parts of stearine, nutmeg 2~10 parts of isopropyl propionate, 0.5~4 part of cetostearyl alcohol, 10~30 parts of dormant oil, 3~12 parts of glycerol, EDETATE SODIUM 0.01~0.5 Part, 0.01~1 part of xanthan gum, 0.1~2 part of Phosphoric acid monohexadecyl ester potassium.Matrix components using mentioned component as massage cream, can To form uniform lotion, places never degenerate for a long time, be easy to use.
Preferably, the massage cream of releiving also contains the following parts by weight: 4 parts of stearine, myristic acid 5 parts of isopropyl ester, cetostearyl alcohol 2,20 parts of dormant oil, 6 parts of glycerol, 0.1 part of EDETATE SODIUM, 0.05 part of xanthan gum, cetanol phosphoric acid 1 part of ester potassium.When in particular by the proportion, the usage experience of massage cream is best.
It preferably, is in an amount 100 parts by weight meters, the massage cream of releiving also includes the water of surplus.
Massage cream of the present invention of releiving also includes preservative and pigment, and the preservative is preferably bis- (methylol) imidazoles 0.3~0.5 parts by weight of ureine, 0.1~0.3 parts by weight of methyl hydroxybenzoate, 0.05~0.15 parts by weight of Nipasol.
The beneficial effects of the present invention are: it releives massage cream the present invention provides one kind, massage cream of the present invention of releiving The effect of can releive skin, play activating microcirculation and removing stasis medicinal, promote blood circulation, improvement cold body, remove rheumatism.
Specific embodiment
In embodiment and comparative example, each raw material is purchased from market, wherein 1,2- pentanediol, 4- tert. butyl cyclohexanol are From Symrise company, Germany, marque is that fragrant skin is happy for purchase1609；The wherein weight hundred of 1,2- pentanediol Dividing the weight percentage that content is 50~75%, 4- tert. butyl cyclohexanol is 25~50%.
Zedoary extract, ginger-root extract, notopterygium root extract, Radix Saposhnikoviae extract and the mixture purchase for hydrogenating Sweet Almond Oil It buys from the careless pharmaceutcal corporation, Ltd in Jiangxi hundred, product type is Humanlimbs Oil Complex；In the product, zedoary is extracted Object, ginger-root extract, notopterygium root extract, Radix Saposhnikoviae extract and the weight ratio for hydrogenating Sweet Almond Oil are as follows: zedoary extract: ginger Root extract: notopterygium root extract: Radix Saposhnikoviae extract: hydrogenation Sweet Almond Oil=15~25:15~25:10~20:15~25:45~ 50。
Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet seed extract, licorice root extract Mixture purchase from Beijing Orient Miao Sen Biotechnology Co., Ltd, product type RoyalTreat；The product is water, fourth Glycol, Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet seed extract, licorice root extract it is mixed Close object, wherein Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet seed extract, licorice extract The weight percentage of the mixture of object is 3.5~7%, and Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract Object, glossy privet seed extract, licorice root extract weight ratio are as follows: 1~2:1~2:0.5~1:0.5~1:0.5~1.
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention It is described further.
Examples 1 to 7
The formula of massage cream of releiving described in Examples 1 to 7 is shown in Table 1, the preparation side for massage cream of releiving described in Examples 1 to 7 Method the following steps are included:
1, Jiang Shui, glycerol, EDETATE SODIUM, xanthan gum Phosphoric acid monohexadecyl ester potassium mutually sequentially add in emulsion pot, begin to warm up Stirring, is heated to 80-85 DEG C, homogeneous, and constant temperature stirs 30 minutes；
2, stearine, isopropyl myristate, cetostearyl alcohol, dormant oil, methyl hydroxybenzoate, Nipasol are heated It to 80 DEG C, is added in emulsion pot, vacuum homogeneous 8 minutes, stirs 10 minutes, start to cool down after vacuum defoaming；
3,50 DEG C are cooled to, lovage root oil, cardamon seed oil, cnidium oil, safflower seed oil, zedoary is added and extracts Object, ginger-root extract, notopterygium root extract, Radix Saposhnikoviae extract, hydrogenation Sweet Almond Oil homogeneous 5 minutes；
4,42 DEG C are cooled to, water, butanediol, Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root is added and extracts Object, glossy privet seed extract, licorice root extract, 1,2- pentanediol, 4- tert. butyl cyclohexanol, pepper extract, bis- (methylols) Imidazolidinyl urea, burnt sugar coloring are stirred until homogeneous to get the massage cream of releiving.
It releives described in 1 Examples 1 to 7 of table the formula of massage cream
Comparative example 1~8
The formula of the massage cream of comparative example 1~8 is shown in Table 2, and the preparation method is the same as that of Example 1~and 7.
The formula of the massage cream of 2 comparative example of table 1~8
Embodiment 8
One, it releives the skin irritation test of massage cream
1, skin irritation test is carried out to rabbit using the massage cream of releiving of embodiment 1 and comparative example 8.
(1) experimental drug
The massage cream of releiving of embodiment 1 and comparative example 8.
(2) experimental animal
Healthy white experiment totally 20 is served only for acute skin irritation test, 2.0~2.5kg of weight with rabbit.During test The independent sub-cage rearing of animal, standard feed feed, free water with ingest.
(3) experimental method and standards of grading
Acute skin irritation test is with multiple skin irritation test method and step according to " cosmetics health specification 2007 editions " in skin irritation test method and step carry out.Wherein, every rabbit body two sides, this implementation is smeared in side The massage cream of releiving of comparative example 8 is smeared in the massage cream of releiving of example 1, side.
Experimental method: before experiment for 24 hours, being lost hair or feathers using 6% sodium sulfide solution, and all tested rabbit backbone two sides are gone Hair (every side is about 10cm*10cm, should be without erythema, oedema and breakage), every rabbit single cage raising (are raised for 24 hours, observation after depilation Whether its skin that loses hair or feathers has damage, this experiment is unfit to do if having skin injury).
Standards of grading: according to " herbal pharmacology experimental methodology " with erythema, oedema etc. for evaluation criterion.Standards of grading and thorn Swash intensity evaluation standard and is shown in Table 2, table 3 respectively.
2 skin wound repair standards of grading of table
3 skin irritatin intensity evaluation standard of table
Integral mean value Intensity
0-0.49 It is non-stimulated
0.50-2.99 Slight stimulation
3.00-5.99 Moderate stimulation
6.00-8.00 Intensity stimulation
(4) result
Acute skin irritation test result is as shown in table 4.
Table 4 releives massage cream to Rabbits with Acute skin irritation test result
The result shows that 1,2- pentanediol, 4- tert. butyl cyclohexanol can reduce other in massage cream of the present invention of releiving Ingredient bring irritation.
Two, it releives the clinical trial of massage cream
1, diagnostic criteria and subject:
Diagnostic criteria: shoulder neck, waist abdomen are often ached, and are often caused because of sitting.
Subject: this group 168 presses above-mentioned diagnostic criteria, clarifies a diagnosis through Chinese medicine as chest impediment and cardialgia, wherein male 85, women 83, the age 28-48 years old.14 groups are randomly divided into, every group of 12 people.Selected subject can cooperate well examination It tests, is able to maintain good daily life system time and eating habit in the trial employment period.
2, given the test agent, sample application method and time
Test group: the massage cream prepared using Examples 1 to 7.
Application method: twice daily, each 1 time sooner or later.Given the test agent is taken to be coated in shoulder neck and waist abdomen in right amount, 3-5 is smeared in massage Minute.
Comparative example group: the massage cream prepared using comparative example 1~7.
Application method: twice daily, each 1 time sooner or later.Given the test agent is taken to be coated in shoulder neck and waist abdomen in right amount, 3-5 is smeared in massage Minute.
3, the course for the treatment of and clinical detection index are tested
The course for the treatment of on probation is 15 days, is effective with the bored pain of subjects subjective, distending pain, secret anguish, cusalgia, shouting pain, colic pain sense disappearance； It is on the contrary then invalid.The results are shown in Table 5.
Table 5 is releived massage cream trial population result
4, result
As can be known from Table 4, compared with comparative example group 1~7, the effective percentage of embodiment 1 is higher, illustrates each ingredient for slow Solution pain can play certain synergy, and each ingredient then influences its effect, and embodiment 1 can be seen compared with embodiment 5~7 Out, the effect of embodiment 1 is best, illustrates in the case where other compositions match unanimous circumstances, vanillyl butyl ether, ginger oil and capsicum Extract can advantageously promote the absorption of traditional Chinese medicine ingredients when using the proportion of embodiment 1.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention And range.

Claims (10)

  1. The massage cream 1. one kind is releived, which is characterized in that contain the following parts by weight: 0.1~3 part of lovage root oil, small 0.1~2 part of cardamom seed oil, 0.1~2 part of cnidium oil, 0.01~1 part of safflower seed oil, 0.05~2.25 part of 1,2- pentanediol and 4- 0.025~1.5 part of tert. butyl cyclohexanol.
  2. 2. massage cream of releiving as described in claim 1, which is characterized in that the massage cream of releiving also includes the group of following parts by weight Point: 0.1~2 part of vanillyl butyl ether, 0.1~3 part of ginger oil, 0.1~3 part of pepper extract.
  3. 3. massage cream of releiving as described in claim 1, which is characterized in that the massage cream of releiving also includes the group of following parts by weight Point: 0.2~0.8 part of vanillyl butyl ether, 1.2~2.4 parts of ginger oil, 0.2~0.8 part of pepper extract.
  4. 4. massage cream of releiving as described in claim 1, which is characterized in that the massage cream of releiving also includes the group of following parts by weight Point: 0.5 part of vanillyl butyl ether, 1.8 parts of ginger oil, 0.5 part of pepper extract.
  5. 5. massage cream of releiving as described in claim 1, which is characterized in that the massage cream of releiving includes the group of following parts by weight Point: 1 part of lovage root oil, 0.5 part of cardamon seed oil, 0.8 part of cnidium oil, 0.1 part of safflower seed oil, 1,2- pentanediol 0.4~ 0.6 part and 0.2~0.4 part of 4- tert. butyl cyclohexanol.
  6. 6. releiving massage cream as claimed in claim 2, which is characterized in that the massage cream of releiving also include zedoary extract, Ginger-root extract, notopterygium root extract, Radix Saposhnikoviae extract and 0.5~3 parts by weight of mixture for hydrogenating Sweet Almond Oil；Preferably, institute Stating massage cream of releiving also includes zedoary extract, ginger-root extract, notopterygium root extract, Radix Saposhnikoviae extract and hydrogenation Sweet Almond Oil 2 parts by weight of mixture.
  7. 7. releiving massage cream as claimed in claim 6, which is characterized in that the massage cream of releiving also include Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet seed extract, 0.035~0.7 part of mixture of licorice root extract； Preferably, the massage cream of releiving also includes Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet seed 0.14~0.28 part of mixture of extract, licorice root extract.
  8. 8. massage cream of releiving as described in claim 1, which is characterized in that the massage cream of releiving also includes the group of following parts by weight Point: 2~8 parts of stearine, 2~10 parts of isopropyl myristate, 0.5~4 part of cetostearyl alcohol, 10~30 parts of dormant oil, 3~12 parts of glycerol, 0.01~0.5 part of EDETATE SODIUM, 0.01~1 part of xanthan gum, 0.1~2 part of Phosphoric acid monohexadecyl ester potassium.
  9. 9. massage cream of releiving as described in claim 1, which is characterized in that the massage cream of releiving also includes the group of following parts by weight Point: 4 parts of stearine, 5 parts of isopropyl myristate, cetostearyl alcohol 2,20 parts of dormant oil, 6 parts of glycerol, EDETATE SODIUM 0.1 Part, 0.05 part of xanthan gum, 1 part of Phosphoric acid monohexadecyl ester potassium.
  10. 10. massage cream of releiving as described in any one of claim 1~9, which is characterized in that massage paste composition total amount by releiving and be 100 parts by weight meters, the massage cream of releiving also include the water of surplus.
CN201910659925.XA 2019-07-19 2019-07-19 One kind is releived massage cream Pending CN110327438A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755352A (en) * 2019-11-29 2020-02-07 广州艾蓓生物科技有限公司 Relaxing vigor cream for dredging channels and activating collaterals and preparation method thereof
CN111643590A (en) * 2020-05-09 2020-09-11 天津芸熙生物技术有限公司 Collateral activating oil and preparation method thereof
CN112353931A (en) * 2020-11-25 2021-02-12 广州旭升化工科技有限公司 Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof
CN112691076A (en) * 2021-01-05 2021-04-23 山东百奥生物医药有限公司 Hypoallergenic soothing epidermal anesthesia cream and preparation method and application thereof
CN113730305A (en) * 2021-09-22 2021-12-03 凯乐康医药科技有限公司 Borneol massage gel
CN114099415A (en) * 2021-10-22 2022-03-01 同芙集团(中国)股份有限公司 Soothing cream and preparation method thereof
CN115737486A (en) * 2022-11-25 2023-03-07 中新国际联合研究院 Fever cream for relieving fatigue and carsickness symptoms and preparation method and application thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755352A (en) * 2019-11-29 2020-02-07 广州艾蓓生物科技有限公司 Relaxing vigor cream for dredging channels and activating collaterals and preparation method thereof
CN111643590A (en) * 2020-05-09 2020-09-11 天津芸熙生物技术有限公司 Collateral activating oil and preparation method thereof
CN111643590B (en) * 2020-05-09 2022-02-25 天津芸熙生物技术有限公司 Collateral activating oil and preparation method thereof
CN112353931A (en) * 2020-11-25 2021-02-12 广州旭升化工科技有限公司 Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof
CN112691076A (en) * 2021-01-05 2021-04-23 山东百奥生物医药有限公司 Hypoallergenic soothing epidermal anesthesia cream and preparation method and application thereof
CN113730305A (en) * 2021-09-22 2021-12-03 凯乐康医药科技有限公司 Borneol massage gel
CN114099415A (en) * 2021-10-22 2022-03-01 同芙集团(中国)股份有限公司 Soothing cream and preparation method thereof
CN115737486A (en) * 2022-11-25 2023-03-07 中新国际联合研究院 Fever cream for relieving fatigue and carsickness symptoms and preparation method and application thereof

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Application publication date: 20191015