CN114099415A - Soothing cream and preparation method thereof - Google Patents

Soothing cream and preparation method thereof Download PDF

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Publication number
CN114099415A
CN114099415A CN202111236280.2A CN202111236280A CN114099415A CN 114099415 A CN114099415 A CN 114099415A CN 202111236280 A CN202111236280 A CN 202111236280A CN 114099415 A CN114099415 A CN 114099415A
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parts
powder
weight
soothing
cream
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周振林
陈潮辉
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Tongfu Health Industry Co ltd
Tongfu Group China Co ltd
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Tongfu Health Industry Co ltd
Tongfu Group China Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/04Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0625Warming the body, e.g. hyperthermia treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645Applicators worn by the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659Radiation therapy using light characterised by the wavelength of light used infrared
    • A61N2005/066Radiation therapy using light characterised by the wavelength of light used infrared far infrared

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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the technical field of skin care products, and discloses a soothing cream and a preparation method thereof. The soothing cream provided by the invention has the effects of promoting blood circulation to remove blood stasis, promoting qi circulation, dispelling cold, relieving pain, warming channels and dredging collaterals, and has a good effect of relieving the ache of shoulder, neck, waist, abdomen or limbs of a human body.

Description

Soothing cream and preparation method thereof
Technical Field
The invention relates to the technical field of skin care products, in particular to a soothing cream and a preparation method thereof.
Background
The soothing cream is a cream body combined with physical massage and is used through massage. Soothing creams have the effect of lubricating and cleansing the skin and serve as an important medium during massage. By matching with the correct massage method, the body and mind can be relieved, the physical strength can be restored, the fatigue can be relieved, the blood circulation can be enhanced, and the beauty and health can be maintained.
Most of the like products on the market at present only adopt heat sensation to activate blood, and cannot achieve the effects of dispelling cold, relieving pain, warming channels and dredging collaterals.
Disclosure of Invention
The invention mainly aims to provide a soothing cream and a preparation method thereof, and aims to solve the technical problem that products on the market cannot achieve the effects of dispelling cold, relieving pain, warming meridians and dredging collaterals.
In order to achieve the purpose, the invention provides a soothing cream which comprises the following components in parts by weight:
5-10 parts of far infrared ceramic powder;
3-8 parts of medicinal moxibustion powder;
0.5-3 parts of azone powder;
5-10 parts of pain relieving powder;
0.3-3 parts of an antiallergic agent;
0.3-1 part of menthol;
0.3-2 parts of vanillyl butyl ether;
70-80 parts of adhesive.
Optionally, in an embodiment, the adhesive is a black matrix, and the black matrix comprises a thermoplastic elastomer.
Optionally, in an embodiment, the adhesive is medical maleic glue.
Optionally, in an embodiment, the antiallergic agent comprises diphenhydramine.
Optionally, in an embodiment, the soothing paste consists of the following components in parts by weight:
7-8 parts of far infrared ceramic powder;
4-5.5 parts of medicinal moxibustion powder;
1-2 parts of azone powder;
7-8 parts of pain relieving powder;
1-2 parts of an antiallergic agent;
0.4-0.7 part of menthol;
0.7-1.5 parts of vanillyl butyl ether;
72-77 parts of black matrix.
Optionally, in an embodiment, the soothing paste consists of the following components in parts by weight:
7-8 parts of far infrared ceramic powder;
4-5.5 parts of medicinal moxibustion powder;
1-2 parts of azone powder;
7-8 parts of pain relieving powder;
1-2 parts of an antiallergic agent;
0.4-0.7 part of menthol;
0.7-1.5 parts of vanillyl butyl ether;
72-77 parts of medical maleic gel.
Optionally, in an embodiment, the soothing paste consists of the following components in parts by weight:
7.5 parts of far infrared ceramic powder;
5.3 parts of medicinal moxibustion powder;
1.5 parts of azone powder;
7.5 parts of pain relieving powder;
0.5 part of menthol;
1.5 parts of an antiallergic agent;
1 part of vanillyl butyl ether;
and 75.2 parts of black matrix.
Optionally, in an embodiment, the soothing paste consists of the following components in parts by weight:
7.5 parts of far infrared ceramic powder;
5.3 parts of medicinal moxibustion powder;
1.5 parts of azone powder;
7.5 parts of pain relieving powder;
0.5 part of menthol;
1.5 parts of an antiallergic agent;
1 part of vanillyl butyl ether;
75.2 parts of medical maleic rubber.
The invention also provides a preparation method of the soothing paste, which comprises the following steps:
weighing 70-80 parts by weight of adhesive, 5-10 parts by weight of far infrared ceramic powder, 3-8 parts by weight of medicinal moxibustion powder, 0.5-3 parts by weight of azone powder, 5-10 parts by weight of pain relieving powder, 0.3-3 parts by weight of antiallergic agent, 0.3-1 part by weight of menthol and 0.3-2 parts by weight of vanillyl butyl ether;
adding the adhesive into a container, heating to the temperature of 120-140 ℃, and uniformly stirring;
adding the far infrared ceramic powder, the medicinal moxibustion powder, the azone powder, the pain relieving powder and the antiallergic agent into the container, and stirring and mixing uniformly;
adding the menthol and the vanillyl butyl ether into the container, stirring and mixing uniformly, and cooling to room temperature to obtain the soothing cream.
Further, in one embodiment, after obtaining the soothing paste, the method further comprises the following steps:
and (3) the soothing ointment is tabletted and pressed flatly to obtain the soothing ointment patch.
The soothing cream provided by the invention has the effects of promoting blood circulation to remove blood stasis, promoting qi circulation, dispelling cold, relieving pain, warming channels and dredging collaterals, and has a good effect of relieving the ache of shoulder, neck, waist, abdomen or limbs of a human body.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
Example 1
The soothing cream comprises the following components in parts by weight:
Figure BDA0003317640310000031
Figure BDA0003317640310000041
the preparation method of the soothing paste comprises the following steps:
1) adding 80 parts by weight of black matrix into a container, heating to the temperature of 120-140 ℃, and uniformly stirring;
2) adding 5 parts by weight of far infrared ceramic powder, 3 parts by weight of medicinal moxibustion powder, 3 parts by weight of azone powder, 5 parts by weight of pain relieving powder and 3 parts by weight of antiallergic agent into the container, and stirring and mixing uniformly;
3) adding 1 part by weight of menthol and 2 parts by weight of vanillyl butyl ether into a container, stirring and mixing uniformly, and cooling to room temperature to obtain a soothing cream;
4) and (3) flatly pressing the soothing ointment into a sheet to be 0.5-1.5 mm thick to obtain the soothing ointment patch.
Example 2
The soothing cream comprises the following components in parts by weight:
Figure BDA0003317640310000042
the preparation method of the soothing paste comprises the following steps:
1) adding 70 parts by weight of black matrix into a container, heating to the temperature of 120-140 ℃, and uniformly stirring;
2) adding 10 parts by weight of far infrared ceramic powder, 8 parts by weight of medicinal moxibustion powder, 0.5 part by weight of azone powder, 10 parts by weight of pain relieving powder and 0.3 part by weight of antiallergic agent into a container, and uniformly stirring and mixing;
3) adding 0.3 weight part of menthol and 0.3 weight part of vanillyl butyl ether into a container, stirring and mixing uniformly, and cooling to room temperature to obtain a soothing cream;
4) and (3) flatly pressing the soothing ointment into a sheet to be 0.5-1.5 mm thick to obtain the soothing ointment patch.
Example 3
The soothing cream comprises the following components in parts by weight:
Figure BDA0003317640310000051
the preparation method of the soothing paste comprises the following steps:
1) adding 75.2 parts by weight of black matrix into a container, heating to the temperature of 120-140 ℃, and uniformly stirring;
2) adding 7.5 parts by weight of far infrared ceramic powder, 5.3 parts by weight of medicinal moxibustion powder, 1.5 parts by weight of azone powder, 7.5 parts by weight of pain relieving powder and 1.5 parts by weight of antiallergic agent into a container, and stirring and mixing uniformly;
3) adding 0.5 part by weight of menthol and 1 part by weight of vanillyl butyl ether into a container, stirring and mixing uniformly, and cooling to room temperature to obtain a soothing cream;
4) and (3) flatly pressing the uniformly stirred materials into a sheet and flattening the sheet to the thickness of 0.5mm-1.5mm to obtain the soothing paste.
Example 4
The soothing cream comprises the following components in parts by weight:
Figure BDA0003317640310000052
Figure BDA0003317640310000061
the preparation method of the soothing paste comprises the following steps:
1) adding 75.2 parts by weight of medical maleic gel into a container, heating to 130 ℃, and uniformly stirring;
2) adding 7.5 parts by weight of far infrared ceramic powder, 5.3 parts by weight of medicinal moxibustion powder, 1.5 parts by weight of azone powder, 7.5 parts by weight of pain relieving powder and 1.5 parts by weight of antiallergic agent into a container, and stirring and mixing uniformly;
3) adding 0.5 part by weight of menthol and 1 part by weight of vanillyl butyl ether into a container, stirring and mixing uniformly, and cooling to room temperature to obtain a soothing cream;
4) and (3) flatly pressing the uniformly stirred materials into a sheet and flattening the sheet to the thickness of 0.5mm-1.5mm to obtain the soothing paste.
In examples 1 to 4, the main component of the black matrix was a styrene-based thermoplastic elastomer; the antiallergic agent is a special antiallergic agent for a plaster, and the main component of the antiallergic agent is diphenhydramine.
In the embodiment of the present application, the far infrared ceramic powder is a white powder, and is formed by mixing a plurality of substances, and the far infrared ceramic powder has a main characteristic function of being capable of radiating far infrared rays (having a higher infrared radiation rate) more than that of a normal object, and when it absorbs external heat energy, it can release far infrared rays with a wavelength of 4-14 micrometers, and is easily absorbed by a human body. The far infrared ray is used for human body health care: the activity of biological macromolecules is activated, so that the molecules of an organism can be excited to be in a high vibration state, the activity of biological macromolecules such as nucleic acid protein and the like is activated, the functions of regulating activities such as organism metabolism, immunity and the like of the biological macromolecules are exerted, the recovery and balance of functions are facilitated, the blood circulation is promoted and improved, and the purposes of beautifying and preserving health are achieved. The medicinal moxibustion powder permeates into meridians and collaterals through transdermal absorption, has good effects of warming muscles and dispelling cold, dispelling wind and eliminating dampness, promoting qi and blood circulation, warming and activating meridians, promoting blood circulation to remove blood stasis and relieving pain, is used in a targeted manner, directly reaches the affected part, has lasting medicinal effect, is simple to use (directly applied to the skin of the affected part), immediately relieves discomfort and can also improve pain of rheumatism, joints, shoulders, necks, lumbar vertebrae, cervical vertebrae, legs and feet; in addition, the pain relieving effect of the pain relieving powder can play a role in relieving pain. Through the combined action of the three main components, the effects of promoting blood circulation to remove blood stasis, promoting qi circulation, dispelling cold and relieving pain and warming and activating meridians are achieved, the discomfort of a user can be relieved, and the health-care tea has a good effect of relieving the human body.
Furthermore, azone powder is matched as a penetrating agent to promote the penetration of the main components, which is beneficial to reducing the dosage of the medicinal powder, and the azone powder can show the highest penetration promoting effect when the concentration of the medicinal powder is lower, thereby achieving the purposes of saving materials and achieving better effect; in addition, it has no irritation to skin mucosa, and can be directly applied on affected skin.
Furthermore, the menthol has the effects of cooling and relieving itching, and the user can feel comfortable and the discomfort can be relieved quickly when the menthol is applied to the skin due to the cooling effect of the menthol.
Furthermore, after the vanillyl butyl ether is added, mild and lasting pyrogen effects can be quickly generated after the vanillyl butyl ether acts on skin, wherein the pyrogen effects comprise the functions of accelerating microcirculation, stimulating subcutaneous fat metabolism, promoting capillary blood circulation and the like, the heat sensation of the vanillyl butyl ether is several times that of a common hot pepper extract, the irritation is low, the heat sensation is kept for several hours, and strong heat sensation can be obtained at an extremely low dosage. Also, vanillyl butyl ether is a stable and safe ingredient with a pleasant vanilla taste.
Further, considering that some people may be allergic to some of the medicinal powders, some anti-allergic agents are added to prevent allergy after use by users with sensitive skin, thereby improving the applicability of the soothing cream.
Furthermore, the black matrix or medical maleic gel is added to be used as an adhesive, so that the components are conveniently and stably applied to the skin, the components in the soothing cream can better permeate into the skin to play a role, and meanwhile, the black matrix can also stimulate nerve endings, dilate blood vessels through reflection, promote local blood circulation, improve the nutrition of peripheral tissues and achieve the effects of detumescence and antiphlogosis.
Application test of soothing cream
The tested person: people who suffer from soreness in the shoulder, neck, waist, abdomen or limbs due to sedentary or exercise. The test persons were randomly divided into four groups of 50 persons each. The selected tested persons can be well matched with the test, and the good daily life and rest time and eating habits can be kept during the trial period.
The using method comprises the following steps: the soothing creams prepared in examples 1-4 were applied to the neck, waist, abdomen and limbs of the human subjects for 2-4 minutes twice a day, once in the morning and evening, for a test period of ten days.
TABLE 1 soothing cream test results
Human subject The pain disappears The pain sensation is obviously weakened The pain sensation is not changed
Example 1 50 35 13 2
Example 2 50 37 11 2
Example 3 50 40 8 1
Example 4 50 40 8 1
As can be seen from the table 1, after the soothing cream is used, most of tested persons feel that the ache has disappeared after the test is finished, part of tested persons feel that the ache is obviously weakened, and only a few of tested persons feel that the ache is unchanged, so that the soothing cream has the effects of promoting blood circulation to remove blood stasis, promoting qi circulation, dispelling cold to relieve pain and warming and activating meridians, and has a good effect on soothing the shoulder, neck, waist and abdomen or limbs of a human body.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; within the idea of the invention, also technical features in the above embodiments or in different embodiments may be combined, steps may be implemented in any order, and there are many other variations of the different aspects of the invention as described above, which are not provided in detail for the sake of brevity; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. The soothing cream is characterized by comprising the following components in parts by weight:
5-10 parts of far infrared ceramic powder;
3-8 parts of medicinal moxibustion powder;
0.5-3 parts of azone powder;
5-10 parts of pain relieving powder;
0.3-3 parts of an antiallergic agent;
0.3-1 part of menthol;
0.3-2 parts of vanillyl butyl ether;
70-80 parts of adhesive.
2. A soothing paste as claimed in claim 1 wherein the adhesive is a black matrix comprising a thermoplastic elastomer.
3. A soothing paste as claimed in claim 1 wherein the adhesive is medical grade maleic gum.
4. A soothing cream as claimed in claim 1 wherein the anti-allergic agent comprises diphenhydramine.
5. The soothing cream of claim 2, wherein the soothing cream is composed of the following ingredients in parts by weight:
7-8 parts of far infrared ceramic powder;
4-5.5 parts of medicinal moxibustion powder;
1-2 parts of azone powder;
7-8 parts of pain relieving powder;
1-2 parts of an antiallergic agent;
0.4-0.7 part of menthol;
0.7-1.5 parts of vanillyl butyl ether;
72-77 parts of black matrix.
6. A soothing cream according to claim 3, wherein the soothing cream consists of the following ingredients in parts by weight:
7-8 parts of far infrared ceramic powder;
4-5.5 parts of medicinal moxibustion powder;
1-2 parts of azone powder;
7-8 parts of pain relieving powder;
1-2 parts of an antiallergic agent;
0.4-0.7 part of menthol;
0.7-1.5 parts of vanillyl butyl ether;
72-77 parts of medical maleic gel.
7. The soothing cream of claim 1, wherein the soothing cream is composed of the following ingredients in parts by weight:
7.5 parts of far infrared ceramic powder;
5.3 parts of medicinal moxibustion powder;
1.5 parts of azone powder;
7.5 parts of pain relieving powder;
0.5 part of menthol;
1.5 parts of an antiallergic agent;
1 part of vanillyl butyl ether;
and 75.2 parts of black matrix.
8. The soothing cream of claim 1, wherein the soothing cream is composed of the following ingredients in parts by weight:
7.5 parts of far infrared ceramic powder;
5.3 parts of medicinal moxibustion powder;
1.5 parts of azone powder;
7.5 parts of pain relieving powder;
0.5 part of menthol;
1.5 parts of an antiallergic agent;
1 part of vanillyl butyl ether;
75.2 parts of medical maleic rubber.
9. The preparation method of the soothing paste is characterized by comprising the following steps:
weighing 70-80 parts by weight of the adhesive according to any one of claims 1-8, 5-10 parts by weight of far infrared ceramic powder, 3-8 parts by weight of medicinal moxibustion powder, 0.5-3 parts by weight of azone powder, 5-10 parts by weight of analgesic powder, 0.3-3 parts by weight of antiallergic agent, 0.3-1 part by weight of menthol and 0.3-2 parts by weight of vanillyl butyl ether;
adding the adhesive into a container, heating to the temperature of 120-140 ℃, and uniformly stirring;
adding the far infrared ceramic powder, the medicinal moxibustion powder, the azone powder, the pain relieving powder and the antiallergic agent into the container, and stirring and mixing uniformly;
adding the menthol and the vanillyl butyl ether into the container, stirring and mixing uniformly, and cooling to room temperature to obtain the soothing cream.
10. The method of claim 9, wherein the step of obtaining the soothing paste further comprises the steps of:
and (3) the soothing ointment is tabletted and pressed flatly to obtain the soothing ointment patch.
CN202111236280.2A 2021-10-22 2021-10-22 Soothing cream and preparation method thereof Pending CN114099415A (en)

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Cited By (1)

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CN115737486A (en) * 2022-11-25 2023-03-07 中新国际联合研究院 Fever cream for relieving fatigue and carsickness symptoms and preparation method and application thereof

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