CN115737486A

CN115737486A - Fever cream for relieving fatigue and carsickness symptoms and preparation method and application thereof

Info

Publication number: CN115737486A
Application number: CN202211490155.9A
Authority: CN
Inventors: 苏健裕; 吕满霞; 范鹏辉; 侯玉超; 凌凤清
Original assignee: Sino Singapore International Joint Research Institute
Current assignee: Huagong Xinyan Shenzhen Technology Co ltd
Priority date: 2022-11-25
Filing date: 2022-11-25
Publication date: 2023-03-07

Abstract

The invention relates to the technical field of daily chemical industry, in particular to a fever cream for relieving fatigue and carsickness symptoms and a preparation method and application thereof. A fever cream for relieving fatigue and carsickness symptoms comprises 60.2 to 95.5 percent of emollient, 1.5 to 9 percent of thickening agent, 1.1 to 20.8 percent of skin conditioner, 0.2 to 2 percent of antioxidant and 2 to 8 percent of adsorbent by mass percent; the skin conditioner comprises vanillyl butyl ether; the adsorbent is silica dimethyl silylate. The heating paste for relieving fatigue and carsickness symptoms provided by the invention is soft, moist but not greasy, has good high temperature resistance, can keep original properties after being placed in a car in hot summer for a long time, and improves the vehicle-mounted practicability of the heating paste; the heating ointment has good extensibility when being smeared, is safe, has no stimulation, is easy to absorb, and can effectively relieve fatigue problems such as muscle tension, ache and the like and relieve carsickness symptoms. The invention also provides a preparation method of the fever cream for relieving fatigue and carsickness symptoms.

Description

Fever cream for relieving fatigue and carsickness symptoms and preparation method and application thereof

Technical Field

The invention relates to the technical field of daily chemical industry, in particular to a fever cream for relieving fatigue and carsickness symptoms and a preparation method and application thereof.

Background

Along with the development of the social economic level and the scientific and technological level, the number of motor vehicles increases day by day, and the hidden danger caused by traffic accidents to the life and property safety of people cannot be ignored while the advantages of convenience and convenience in traveling are brought. According to data statistics, except for external objective factors such as complex weather and poor traffic road conditions, the occurrence of traffic accidents is caused by drunk driving, overspeed driving, overload driving, fatigue driving and the like. Among them, fatigue driving, which is a factor that a driver may unconsciously ignore, results in an accident rate as high as 45%. The driver keeps the same sitting posture for a long time, so that the muscles of the body are in a tense state for a long time, and the tense state of the muscles cannot be relieved timely due to lack of exercise, irregular living habits and the like, and the muscles gradually have symptoms of ache, stiffness and the like. At present, the means for relieving the symptoms mainly comprises applying a cortical plaster or a massage cream outside a body, but the cortical plaster has poor use feeling, thick smell and poor air permeability, and is easy to cause side effects such as skin itch, red swelling and the like; the massage cream sold on the market can achieve the effect of effectively relieving fatigue by matching with a professional massage means, has poor high-temperature resistance, cannot be placed in a vehicle for a long time and keeps original properties in hot summer, and limits the vehicle-mounted practicability of the massage cream.

Car sickness is a common and frequent motion sickness, and is caused by various reasons, such as vehicle swaying, bumping, air non-circulation, gasoline smell generated by motor vehicles, and the like, which mainly show symptoms of dizziness, epigastric discomfort, hypodynamia, nausea, vomiting, cold sweat, and the like. At present, carsickness is prevented by using carsickness patches or taking medicines. The carsickness plaster has short action time and unobvious effect; carsickness prevention medicines are mainly sedative and antiemetic medicines, inhibit excitation of nerve centers, and relieve spasm of digestive tracts, but have large side effects, and symptoms such as dry mouth, poor vision and the like can also occur.

The above drawbacks are expected to be overcome by those skilled in the art.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides the heating ointment for relieving fatigue and carsickness symptoms and the preparation method and the application thereof; the heating ointment for relieving fatigue and carsickness has good high-temperature resistance, and good effects of relieving fatigue and carsickness.

In order to achieve the purpose, the invention provides a fever cream for relieving fatigue and carsickness symptoms, which comprises 60.2 to 95.5 percent of emollient, 1.5 to 9 percent of thickening agent, 1.1 to 20.8 percent of skin conditioner, 0.2 to 2 percent of antioxidant and 2 to 8 percent of adsorbent by mass percent; the skin conditioner comprises vanillyl butyl ether; the adsorbent is silica dimethyl silylate.

Further, the skin lotion comprises, by mass, 5-10% of white oil, 20-30% of vaseline, 15-25% of polyisobutylene, 1-6% of tridecyl alcohol trimellitate, 5-13% of isopropyl palmitate, 1-5% of hydrogenated coconut oil, 1-10% of shea butter (Butyrschwerum PARKII) and 5-10% of caprylic/capric triglyceride.

Further, the thickening agent comprises 0.5-3% of ozokerite, 0.5-3% of synthetic wax and 0.5-3% of microcrystalline wax by mass percent.

Further, the skin conditioner comprises, by mass, 0-10% of litsea cubeba oil, 1-10% of borneol oil and 0.1-0.8% of vanillyl butyl ether.

Further, the antioxidant is tocopherol acetate.

The invention also provides a preparation method of the fever cream for relieving fatigue and carsickness symptoms, which comprises the following steps:

s1, adding polyisobutylene, tridecyl alcohol trimellitate and dimethyl silylated silica into a reactor No. 1, heating, and stirring until the dimethyl silylated silica is uniformly dispersed to obtain a component A;

s2, adding white oil, vaseline, isopropyl palmitate, hydrogenated coconut oil, shea butter (Butyrschwerum Parkii) fruit fat, caprylic/capric triglyceride, ceresin, synthetic wax and microcrystalline wax into a reactor No. 2, heating, and stirring until all materials are completely dissolved to obtain a component B;

s3, adding the component B prepared in the step S2 into the component A prepared in the step S1 under the conditions of heating and stirring, and uniformly stirring; and then adding the tocopherol acetate, the borneol oil and the vanillyl butyl ether, continuously stirring, canning while the mixture is hot after uniformly stirring, and cooling to room temperature to obtain a finished heating paste product.

Further, the heating in the S1, the S2 and the S3 is carried out to 82-95 ℃.

Further, the cooling mode in S3 to room temperature is natural cooling.

Further, the raw materials added after the component B is added into the component A and uniformly stirred in the step S3 also comprise litsea cubeba oil.

The invention also provides application of the fever cream for relieving the fatigue and the carsickness symptoms.

Compared with the prior art, the invention has the following beneficial effects:

1. the fever cream for relieving fatigue and carsickness symptoms adopts medical vaseline as a matrix emollient, and can form a closed membrane on the surface of skin to promote skin hydration; simultaneously, white oil, hydrogenated coconut oil, fruit fat of Butyrospermum PARKII, isopropyl palmitate, polyisobutylene, caprylic/capric triglyceride and tridecyl alcohol trimellitate are reasonably compounded, so that the heating paste has good moisture retention and moistening performance, and can be quickly absorbed by skin;

2. the ceresin, the synthetic wax and the microcrystalline wax are selected as the same type of vaseline, the consistency of a vaseline matrix is preferably adjusted, the thermal stability of the heating ointment can be improved, and the ductility of the product can be promoted;

3. dimethyl silica silylate is selected as an adsorbent, so that oil control and seborrhea resistance can be effectively realized, and meanwhile, the dimethyl silica silylate has the function of stabilizing the system under a high-temperature condition (60-70 ℃), so that the heating paste can be prevented from being dissolved into a liquid state at a high temperature, and the vehicle-mounted practicability of the heating paste is improved;

4. the tocopherol acetate is selected, so that the skin metabolism can be promoted, the pigmentation can be prevented, the skin elasticity can be improved, the skin can be moistened, and the skin care and beauty effects can be achieved; the tocopherol acetate is also an excellent antioxidant, and can prevent or delay the rancidity of grease in the heating paste;

5. the litsea cubeba oil and borneol oil are selected as natural plant volatile essential oil, are essence and have multiple effects of oxidation resistance, antibiosis, corrosion prevention and the like; the Longnao oil also has pharmacological activities of resisting inflammation, sterilizing, promoting granulation, relieving itching, promoting drug absorption and the like, can promote the absorption of the febrile ointment and shorten the onset time of the febrile ointment; meanwhile, the dragon's brain oil also has the effects of inducing resuscitation, refreshing mind, relieving pain and calming nerves, can effectively relieve carsickness symptoms and improves the travelling comfort level;

6. the vanillyl butyl ether is selected, and the heating ointment acts on the skin, can quickly activate a vanilloid receptor (a channel compound protein), opens a calcium channel, depolarizes a membrane of a primary sensory nerve terminal, can quickly generate strong heat sensation within about 2min and lasts for about 2h, but the actual temperature of the skin does not obviously change, and has the effects of diminishing inflammation, easing pain, promoting blood circulation, removing blood stasis, sterilizing, relieving itching, dispelling wind and dampness and the like.

Drawings

FIG. 1 is a schematic flow chart of a preparation method of a fever ointment for relieving fatigue and carsickness symptoms, which is provided by the invention;

FIG. 2 is a graph showing the results of sensory evaluation of the finished exothermic pastes obtained in examples 1 to 3 of the present invention after trial use for 1 time by a human volunteer.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

A fever cream for relieving fatigue and carsickness symptoms comprises 60.2 to 95.5 percent of emollient, 1.5 to 9 percent of thickening agent, 1.1 to 20.8 percent of skin conditioner, 0.2 to 2 percent of antioxidant and 2 to 8 percent of adsorbent by mass percent; the skin conditioner comprises vanillyl butyl ether; the adsorbent is silica dimethyl silylate.

Further, the antioxidant is tocopherol acetate.

s3, adding the component B prepared in the step S2 into the component A prepared in the step S1 under the conditions of heating and stirring, and uniformly stirring; and then adding the tocopherol acetate, the borneol oil and the vanillyl butyl ether, continuously stirring, canning while the mixture is hot after uniform stirring, and cooling to room temperature to obtain a finished product of the heating ointment.

Further, the heating in S1, S2 and S3 is carried out to 82-95 ℃.

Further, the cooling mode in S3 to room temperature is natural cooling.

Further, the raw materials added after the component B is added into the component A in the S3 and uniformly stirred also comprise litsea cubeba oil.

The present invention will be described in further detail with reference to specific examples.

Example 1

The fever cream for relieving fatigue and carsickness symptoms comprises 81.4% of an emollient, 4.5% of a thickening agent, 10.1% of a skin conditioner, 2% of an antioxidant and 2% of an adsorbent by mass percent; the adsorbent is silica dimethyl silylate; the antioxidant is tocopherol acetate.

Specifically, the skin lotion comprises 18.4% of polyisobutylene, 1% of tridecyl trimellitate, 10% of white oil, 20% of vaseline, 13% of isopropyl palmitate, 1% of hydrogenated coconut oil, 10% of fruit fat of Butyrospermum PARKII (Butyrum PARKII) and 8% of caprylic/capric triglyceride by mass percent.

The thickening agent comprises 0.5% of ozokerite, 3% of synthetic wax and 1% of microcrystalline wax by mass percent.

The skin conditioner comprises, by mass, 10% of dragon oil and 0.1% of vanillyl butyl ether.

A preparation method of a fever cream for relieving fatigue and carsickness symptoms comprises the following steps:

s1, adding polyisobutylene, tridecyl alcohol trimellitate and dimethyl silica silylate into a reactor No. 1, heating to 82-95 ℃, and stirring until the dimethyl silica silylate is uniformly dispersed to obtain a component A;

s2, adding white oil, vaseline, isopropyl palmitate, hydrogenated coconut oil, shea butter (Butyrschwerum Parkii) fruit fat, caprylic/capric triglyceride, ozokerite, synthetic wax and microcrystalline wax into a reactor No. 2, heating to 82-95 ℃, and stirring until all materials are completely dissolved to obtain a component B;

s3, adding the component B prepared in the step S2 into the component A prepared in the step S1 under the condition of heating to 82-95 ℃ and stirring, and stirring uniformly; and then adding the tocopherol acetate, the borneol oil and the vanillyl butyl ether, continuously stirring, canning while the mixture is hot after uniform stirring, and naturally cooling to room temperature to obtain a finished product of the heating ointment.

Example 2

The fever cream for relieving fatigue and carsickness symptoms comprises, by mass, 74.7% of an emollient, 4.5% of a thickener, 11.8% of a skin conditioner, 1% of an antioxidant and 8% of an adsorbent; the adsorbent is silica dimethyl silylate; the antioxidant is tocopherol acetate.

Specifically, the emollient comprises, by mass, 15% of polyisobutylene, 6% of tridecyl alcohol trimellitate, 5.7% of white oil, 30% of vaseline, 5% of isopropyl palmitate, 3% of hydrogenated coconut oil, 5% of fruit fat of Butyrospermum PARKII (Butyrrhiza PARKII), and 5% of caprylic/capric triglyceride.

The thickening agent comprises 1% of ozokerite, 0.5% of synthetic wax and 3% of microcrystalline wax by mass percentage.

The skin conditioner comprises, by mass, 10% of litsea cubeba oil, 1% of borneol oil and 0.8% of vanillyl butyl ether.

s1, adding polyisobutylene, tridecyl alcohol trimellitate and dimethyl silylated silica into a reactor No. 1, heating to 82-95 ℃, and stirring until the dimethyl silylated silica is uniformly dispersed to obtain a component A;

s3, adding the component B prepared by the step S2 into the component A prepared by the step S1 under the condition of heating to 82-95 ℃ and stirring, and stirring uniformly; and then adding the tocopherol acetate, the litsea cubeba oil, the borneol oil and the vanillyl butyl ether, continuously stirring, canning while the mixture is hot after uniformly stirring, and naturally cooling to room temperature to obtain a finished product of the heating ointment.

Example 3

The fever cream for relieving fatigue and carsickness symptoms comprises 79.8% of an emollient, 4.5% of a thickening agent, 10.5% of a skin conditioner, 0.2% of an antioxidant and 5% of an adsorbent by mass percent; the adsorbent is silica dimethyl silylate; the antioxidant is tocopherol acetate.

Specifically, the skin-moistening agent comprises, by mass, 25% of polyisobutylene, 4% of tridecyl alcohol trimellitate, 5% of white oil, 21.8% of vaseline, 8% of isopropyl palmitate, 5% of hydrogenated coconut oil, 1% of fruit fat of Butyrospermum PARKII (Butyrum PARKII) and 10% of caprylic/capric triglyceride.

The thickening agent comprises 3% of ozokerite, 1% of synthetic wax and 0.5% of microcrystalline wax in percentage by mass.

The skin conditioner comprises 5% of litsea cubeba oil, 5% of borneol oil and 0.5% of vanillyl butyl ether by mass percentage.

s3, adding the component B prepared in the step S2 into the component A prepared in the step S1 under the condition of heating to 82-95 ℃ and stirring, and stirring uniformly; and then adding the tocopherol acetate, the litsea cubeba oil, the borneol oil and the vanillyl butyl ether, continuously stirring, canning while the mixture is hot after uniform stirring, and naturally cooling to room temperature to obtain a finished product of the heating ointment.

(I) product Performance testing

TABLE 1 physicochemical parameters of the fever creams for alleviating the symptoms of fatigue and carsickness prepared in examples 1-3

(II) high temperature resistance test

The heating pastes for relieving fatigue and carsickness symptoms prepared in examples 1-3 are respectively taken and placed in an oven at 60 ℃ for 4h, the room temperature does not need to be recovered, the paste properties of the existing product are completely changed into liquid which is very easy to flow through visual observation, and the paste properties of the finished heating pastes prepared in examples 1-3 are changed into softer paste which is slightly flowing.

The test results show that the fever cream for relieving the fatigue and the carsickness provided by the invention can still keep the original cream properties after being treated at a high temperature of 60 ℃. Therefore, the heating ointment for relieving the fatigue and the carsickness provided by the invention has better high temperature resistance.

(III) fatigue-alleviating Effect test

(1) The finished exothermic paste prepared in examples 1 to 3 were tried by 30 volunteers of the driving group, and the sensory evaluation results after 1 trial are shown in fig. 2. The sensory evaluation of each item was evaluated at a score of 10, and the higher the score was, the more noticeable the sensation of the corresponding item, for example, a sensory evaluation of 9 points indicated that the product had a distinct sensory sensation.

As can be seen from fig. 2, the finished heat-generating paste obtained in example 3 had the same gloss and spreadability as those of the finished heat-generating pastes obtained in examples 1 and 2, but the finished heat-generating paste obtained in example 3 imparted the skin with significantly higher absorbency, softness, and heat sensation than those of the finished heat-generating pastes obtained in examples 1 and 2. Meanwhile, the residual feeling of the finished heating paste prepared in the example 3 on the skin is obviously less than that of the finished heating paste prepared in the examples 1 and 2, and volunteers prefer to try the finished heating paste prepared in the example 3. Sensory evaluation of the finished exothermic cream prepared in example 3 was superior to those of the finished exothermic cream prepared in examples 1 and 2 in overall evaluation.

(2) The volunteers respectively use the finished fever ointment prepared in the embodiment 1-3 twice a day, 1 time in the morning and evening, and 15 days in total, and apply the finished fever ointment prepared in the embodiment 1-3 on the neck, shoulder, waist and abdomen in proper amount and then uniformly spread. The results are shown in Table 2.

TABLE 2 fatigue test results

From the test results in table 2, it can be seen that the finished exothermic ointment prepared in example 3 has a higher effective rate for relieving fatigue, which indicates that the reasonable combination of the components has a certain synergistic effect on the fatigue relieving effect.

In conclusion, the overall effect, user acceptance and test effect of the heat-generating paste products obtained in example 3 were better than those of the heat-generating paste products obtained in examples 1 and 2.

(IV) carsickness relief effect test

The finished products of the fever creams prepared in the examples 1-3 are respectively tried by 30 volunteers with carsickness history; volunteers sit on the automobile, the automobile runs for 300 kilometers on a highway, and after the completion, the effectiveness of the finished heating ointment prepared in each embodiment for relieving carsickness symptoms is evaluated, and the results are shown in the following table 3.

TABLE 3 test effect on car sickness alleviation

	Obviously relieve the symptoms of carsickness	Slightly relieving carsickness symptoms	No symptom of car sickness
				Example 1	8	2	0
Example 2	2	4	4
				Example 3	5	3	2

From the above results, it is understood that the exothermic ointment products obtained in examples 1 to 3 had the effect of relieving the symptoms of carsickness to some extent. The finished exothermic ointment prepared in example 1 has the best effect of relieving motion sickness symptoms, which shows that the resuscitation and resuscitation effects of the dragon oil are obviously enhanced along with the increase of the dosage of the dragon oil.

In conclusion, the heating paste for relieving fatigue and carsickness provided by the invention has good high-temperature resistance, and can be placed in a car for a long time in hot summer, so that the vehicle-mounted practicability of the heating paste is improved; meanwhile, the heating ointment also has the effects of relieving fatigue and relieving carsickness symptoms.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims

1. The fever cream for relieving the symptoms of fatigue and carsickness is characterized by comprising 60.2 to 95.5 percent of emollient, 1.5 to 9 percent of thickening agent, 1.1 to 20.8 percent of skin conditioner, 0.2 to 2 percent of antioxidant and 2 to 8 percent of adsorbent by mass percent;

the skin conditioner comprises vanillyl butyl ether; the adsorbent is silica dimethyl silylate.

2. The heat-generating ointment for relieving fatigue and motion sickness as claimed in claim 1, wherein the emollient comprises, by mass, 5-10% of white oil, 20-30% of vaseline, 15-25% of polyisobutylene, 1-6% of tridecyl alcohol trimellitate, 5-13% of isopropyl palmitate, 1-5% of hydrogenated coconut oil, 1-10% of shea butter (Butyripermm parkii) fruit fat, and 5-10% of caprylic/capric triglyceride.

3. The fever cream capable of relieving fatigue and carsickness symptoms as claimed in claim 1, wherein the thickening agent comprises 0.5-3% by mass of ozokerite, 0.5-3% by mass of synthetic wax and 0.5-3% by mass of microcrystalline wax.

4. The fever cream capable of relieving fatigue and carsickness symptoms according to claim 1, wherein the skin conditioner comprises 0-10% of litsea cubeba oil, 1-10% of borneol oil and 0.1-0.8% of vanillyl butyl ether by mass percent.

5. The exothermic ointment for relieving fatigue and motion sickness of claim 1, wherein the antioxidant is tocopheryl acetate.

6. A method for preparing a fever cream for alleviating the symptoms of fatigue and motion sickness according to any one of claims 1 to 5, which comprises the following steps:

s2, adding white oil, vaseline, isopropyl palmitate, hydrogenated coconut oil, shea butter (Butyrs PERUMMPPARKII) fruit fat, caprylic/capric triglyceride, ceresin, synthetic wax and microcrystalline wax into a reactor No. 2 and a reactor No. 2, heating, and stirring until all materials are completely dissolved to obtain a component B;

s3, adding the component B prepared by the step S2 into the component A prepared by the step S1 under the conditions of heating and stirring, and uniformly stirring; and then adding the tocopherol acetate, the borneol oil and the vanillyl butyl ether, continuously stirring, canning while the mixture is hot after uniformly stirring, and cooling to room temperature to obtain a finished heating paste product.

7. The method for preparing a fever cream for alleviating the symptoms of fatigue and motion sickness as claimed in claim 6, wherein the heating in S1, S2 and S3 is carried out to 82-95 ℃.

8. The method for preparing a fever cream for alleviating the symptoms of fatigue and carsickness as claimed in claim 6, wherein the cooling in S3 is natural cooling.

9. The method for preparing a fever cream for relieving fatigue and motion sickness as claimed in claim 6, wherein the raw materials added after the component B is added to the component A and uniformly stirred in the step S3 further comprise litsea cubeba oil.

10. The use of a fever paste for the relief of symptoms of fatigue and motion sickness according to any one of claims 1 to 5, wherein the fever paste is used for the relief of symptoms of fatigue and motion sickness.