CN103550511B

CN103550511B - Vegetable composition of a kind of delay skin aging and preparation method thereof

Info

Publication number: CN103550511B
Application number: CN201310472551.3A
Authority: CN
Inventors: 杜江
Original assignee: Individual
Current assignee: Du Jiang
Priority date: 2013-10-11
Filing date: 2013-10-11
Publication date: 2016-03-23
Anticipated expiration: 2033-10-11
Also published as: CN103550511A

Abstract

The present invention relates to a kind of vegetable composition of delay skin aging, its component is the extract of the raw material of following weight portion: Radix Asparagi 30-70 part, Radix Ginseng 10-50 part, Semen Vitis viniferae 10-50 part, Radix Angelicae Sinensis 10-50 part, Semen Armeniacae Amarum 10-50 part, Rhizoma Polygonati 10-50 part, Radix Ophiopogonis 10-50 part, Radix Astragali 10-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part, Poria 10-50 part, Bulbus Lilii 10-50 part.Vegetable composition of the present invention can play to skin aging the effect delayed, and use safety.

Description

Vegetable composition of a kind of delay skin aging and preparation method thereof

Technical field

The present invention relates to vegetable composition of a kind of delay skin aging and preparation method thereof, belong to cosmetic field.

Background technology

Skin safeguards human life and healthy pith, and direct and extraneous contact is the first barrier of body, is very easily subject to the impact of environmental factors and causes damage.These are social in the changes of the aging of social population, the deterioration of environment and people's life habit etc., epochal character problem causes the problem of aging of skin to be on the rise, when people will more and more need long, modulability and preventative skin care item efficiently.

Along with going deep into of medical research, more careful attitude held by the cosmetics of consumers in general to the manufacture of life-time service chemosynthesis material.Although the preparation that traditional Chinese herbal medicine is novel cosmetic provides wide raw material sources, also find much to skin and mucous membrane irritation strong, easily produce the problems such as anaphylaxis.Therefore we should from comprise Chinese herbal medicine natural plants more widely obtain can tackle efficient, safe modulability, the nutrient composite matter that cause skin aging factor at present.

Summary of the invention

Vegetable composition of the present invention forms primarily of the crude drug of following weight portion: Radix Asparagi 30-70 part, Radix Ginseng 10-50 part, Semen Vitis viniferae 10-50 part, Radix Angelicae Sinensis 10-50 part, Semen Armeniacae Amarum 10-50 part, Rhizoma Polygonati 10-50 part, Radix Ophiopogonis 10-50 part, Radix Astragali 10-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part, Poria 10-50 part, Bulbus Lilii 10-50 part.

Preferably, each crude drug and weight portion thereof are respectively: Radix Asparagi 40-60 part, Radix Ginseng 20-40 part, Semen Vitis viniferae 20-40 part, Radix Angelicae Sinensis 20-40 part, Semen Armeniacae Amarum 20-40 part, Rhizoma Polygonati 20-40 part, Radix Ophiopogonis 20-40 part, Radix Astragali 20-40 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Poria 20-40 part, Bulbus Lilii 20-40 part.

More preferably, each crude drug and weight portion thereof are respectively: Radix Asparagi 50 parts, Radix Ginseng 30 parts, Semen Vitis viniferae 30 parts, Radix Angelicae Sinensis 30 parts, 30 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 30 parts, Radix Ophiopogonis 30 parts, the Radix Astragali 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts, 30 parts, Poria, Bulbus Lilii 30 parts.

The present invention also provides the preparation method of above-mentioned vegetable composition: the mixing of various raw material is placed in extractor, extracts, concentrated extracting solution and get final product with water or hydrophilic solvent.

Described hydrophilic solvent is ethanol, methanol, acetone, butanediol, propylene glycol or ethyl acetate etc.

Described extraction can be the methods such as decoction, reflux, extract, merceration, percolation.

The present invention also provides a kind of galenical be made up of above-mentioned vegetable composition and excipient, and this galenical can be solution, ointment, membrane, Emulsion or cream kind, superfine powder.Such as, in the concentrated solution of gained, add a certain amount of ethanol or polyhydric alcohol and appropriate antiseptic, can be made into solution.

The present invention also provides described vegetable composition preparing the application in medicine or cosmetics.

Beneficial effect

In above-mentioned formula, Radix Asparagi, Radix Ginseng, Semen Vitis viniferae have the effect of antioxidation, scavenging free radicals, the destruction of the radical pair human skin cell stoping environmental pollution and radiation to produce, delay skin aging, and Radix Asparagi has inhibitory action to multiple coccus and bacillus; Radix Angelicae Sinensis, can expand peripheral blood vessel, reduces vascular resistance, increases superficial cutaneous capillaries blood circulation etc.; Fatty oil contained in Semen Armeniacae Amarum can make keratodermatitis soften, and has effects such as moisturizing skin protection; The Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Polygonati have antiinflammatory, the effect such as antibacterial; Poria, Bulbus Lilii have tranquilizing effect.

The each plant component fit applications of the present invention, can play following good effect:

1. improve cutaneous circulation, play promotion skin metabolism, improve the effect of cell viability;

2. radiation resistance, alleviates the negative effect that long-time office work causes skin;

3. antibacterial, moisturizing, scavenging free radicals, the negative effect that alleviation operating pressure and environmental pollution cause skin;

4. pair skin is without any irritant reaction, is applicable to life-time service.

In sum, the various societies that can the tackling of vegetable composition of the present invention causes skin aging at present, environmental factors, play the effect delayed to skin aging, and use safety.

Detailed description of the invention

Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.

Embodiment 1

Prescription forms: Radix Asparagi 70 parts, Radix Ginseng 10 parts, Semen Vitis viniferae 50 parts, Radix Angelicae Sinensis 10 parts, 50 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 10 parts, Radix Ophiopogonis 50 parts, the Radix Astragali 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 50 parts, 10 parts, Poria, Bulbus Lilii 150 parts.

The preparation method of vegetable composition of the present invention:

Each raw material is cleaned and is placed in extractor, add 4 times amount deionized waters and decoct twice, each 30 minutes, after extracting liquid filtering is concentrated, namely obtain vegetable composition of the present invention.

Embodiment 2

Prescription forms: Radix Asparagi 30 parts, Radix Ginseng 50 parts, Semen Vitis viniferae 10 parts, Radix Angelicae Sinensis 50 parts, 10 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 50 parts, Radix Ophiopogonis 10 parts, the Radix Astragali 50 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, 50 parts, Poria, Bulbus Lilii 10 parts.

The preparation method of vegetable composition of the present invention:

Each raw material is cleaned and is placed in extractor, add 4 times amount 75% alcoholic solution reflux, extract, twice, each 30 minutes, after extracting liquid filtering is concentrated, namely obtain vegetable composition of the present invention.

Embodiment 3

Prescription forms: Radix Asparagi 40 parts, Radix Ginseng 40 parts, Semen Vitis viniferae 20 parts, Radix Angelicae Sinensis 40 parts, 20 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 40 parts, Radix Ophiopogonis 20 parts, the Radix Astragali 40 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, 40 parts, Poria, Bulbus Lilii 20 parts.

The preparation method of vegetable composition of the present invention:

Each raw material is cleaned and is placed in extractor, add 4 times amount 60% alcoholic solution reflux, extract, twice, each 30 minutes, after extracting liquid filtering is concentrated, namely obtain vegetable composition of the present invention.

Embodiment 4

Prescription forms: Radix Asparagi 60 parts, Radix Ginseng 20 parts, Semen Vitis viniferae 40 parts, Radix Angelicae Sinensis 20 parts, 40 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 20 parts, Radix Ophiopogonis 40 parts, the Radix Astragali 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 40 parts, 20 parts, Poria, Bulbus Lilii 40 parts.

The preparation method of vegetable composition of the present invention:

Each raw material is cleaned and is placed in extractor, add 4 times amount methanol eddies and extract twice, each 30 minutes, after extracting liquid filtering is concentrated, namely obtain vegetable composition of the present invention.

Embodiment 5

Prescription forms:

Radix Asparagi 50 parts, Radix Ginseng 30 parts, Semen Vitis viniferae 30 parts, Radix Angelicae Sinensis 30 parts, 30 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 30 parts, Radix Ophiopogonis 30 parts, the Radix Astragali 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts, 30 parts, Poria, Bulbus Lilii 30 parts.

The preparation method of vegetable composition of the present invention:

Each raw material is cleaned and is placed in extractor, add 4 times amount acetone reflux and extract twice, each 30 minutes, after extracting liquid filtering is concentrated, namely obtain vegetable composition of the present invention.

Embodiment 6

The vegetable composition of Example 1 gained, adds water and propylene glycol, makes the solution containing propylene glycol 30%, and after filtering, namely adding preservative agent obtains solution a.The concentration of this solution is calculated as 1.5 grams per milliliters according to every milliliter contained amount.

Embodiment 7

The vegetable composition of Example 1 gained, adds water and 1,3 one butanediols, makes containing 1, the solution of 3 one butanediols 30%, and after filtering, namely adding preservative agent obtains solution b.The concentration of this solution is calculated as 1.5 grams per milliliters according to every milliliter contained amount.

Embodiment 8

Rabbit Skin Irritation Test

Test specimen: the solution of embodiment 6 gained

Test method: with reference to " cosmetics health specification " (2007 editions)

Experimental animal: white rabbit

Experimental result: 7 days Skin Irritation Test, have no irritant reaction.

Embodiment 9

Oxidation Resistance Test

Embodiment 1 extract compares with Semen Vitis viniferae extract Scavenging ability: the extract of embodiment 1 compositions and Semen Vitis viniferae of getting equivalent does its antioxidant effect of scavenging free radicals experimental evaluation respectively, and experimental data knows table 1:

Table 1 present composition antioxidant effect

It can be seen from the table embodiment 1 extract Scavenging ability, far away higher than the extract of single Semen Vitis viniferae.

Embodiment 10

Clinical effectiveness

1, clinical data:

Select women 60 example meeting skin aging standard, 28 ~ 35 years old age.Be divided into test group 32 example at random, matched group 28 example.

2, skin aging standard:

Skin aging main manifestations is: dry, coarse, desquamation, microgroove, shallow complexion, irregular pigment alteration, and the sensitivity of skin increases, and elasticity reduces.Get rid of skin of face and have erosion, vesicle and breakage, high susceptibility skin, have long-term chemical material contact history and cause skin allergy and Pigmented medicinal application history for a long time.

3, method:

Test group: sooner or later after clean, carries out appropriate time massage by solution uniform application obtained for above-described embodiment 6 in skin of face.The course for the treatment of is 2 months.

Matched group: after clean of morning and evening, add the blank solvent in above-described embodiment 6 in facial uniform application, i.e. 30% aqueous solution of propylene glycol.The course for the treatment of is 2 months.

Two groups are respectively carried out symptom score 1 time by special messenger before and after treatment.

4, female face skin aging Quantitative marking standard:

1. coarse, dry: to be designated as 1 point with tactile rough of buccal, forehead, mouth Zhou Youyi place area skin; With buccal, forehead, have two place's area skin tactile in mouth week a rough or position, place touch be in the way companion desquamation be designated as 2 points; 3 points are designated as with the companion's desquamation that is in the way that is all rough or that be greater than place's area skin tactile that buccal, forehead, mouth all places area skin touch.

2. fine wrinkle: there is shallow thin crows-feet at canthus place, the plain wrinkle person of forehead is designated as 1 point; Canthus place, forehead, Face and cheek thick tail stricture of vagina person are designated as 2 points; Canthus place, forehead, Face and cheek, all places of mouth and cervical region have obvious wrinkle person to be designated as 3 points.

3. irregular pigment alteration: only based on buccal, area is no more than more than 30% of whole face, and paler colour, in filbert, be dispersed in distribution and do not merge in flakes, be designated as 1 point; Have brown spot with two cheeks, forehead, area exceedes more than 50% of whole face, and the color of speckle is comparatively dark, and in dark brown, and fusion is designated as 2 points in flakes; Have with positions such as forehead, buccal, nose both sides, lip weeks the deep brown spot be dispersed in, more than 70% person that area accounts for whole face is designated as 3 points.

4. complexion is withered firefly: shallow complexion is glossy is designated as 1 point, and ochriasis tarnish is designated as 2 points, and complexion is withered and yellow dark and gloomyly to be had no gloss and be designated as 3 points.

5. skin elasticity: can recover rapidly after pressing but produce more wrinkle around press section to be designated as 1 point; Skin elasticity is not good enough, and after pressing, 1 ~ 2s can recover to be designated as 2 points; Skin elasticity is poor, recuperator can be designated as 3 points after pressing more than 2s.

5, efficacy assessment standard:

Score value × 100% before symptom integral score value improvement rate=(treat front symptom integral score value one and treat rear symptom integral score value)/treatment.

Effective: symptom integral value reduces >=70%; Effective: symptom integral value reduces >=50%; Invalid: symptom has no obviously to be improved or instead sees deterioration, and symptom integral value reduces <50%.

6, result

Before and after two groups of treatments, clinical symptoms integral contrast is in table 2.

Table 2.2 group treatment front and back clinical symptoms integral contrast ( point)

Two groups of comparitive study are in table 3.

Table 3.2 group comparitive study

Claims

1. the vegetable composition of a delay skin aging, it is characterized in that, the weight portion of each crude drug is respectively: Radix Asparagi 50 parts, Radix Ginseng 30 parts, Semen Vitis viniferae 30 parts, Radix Angelicae Sinensis 30 parts, 30 parts, Semen Armeniacae Amarum, Rhizoma Polygonati 30 parts, Radix Ophiopogonis 30 parts, the Radix Astragali 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts, 30 parts, Poria, Bulbus Lilii 30 parts.

2. the preparation method of vegetable composition as claimed in claim 1, is characterized in that, various raw material mixing is placed in extractor, extracts with water or hydrophilic solvent, concentrated extracting solution and get final product.

3. the preparation method of vegetable composition as claimed in claim 2, it is characterized in that, described hydrophilic solvent is ethanol, methanol, acetone, butanediol, propylene glycol.

4., with the vegetable composition of delay skin aging, it is characterized in that, it is made up of vegetable composition according to claim 1 and excipient.

5. vegetable composition as claimed in claim 4, it is characterized in that, it is solution, ointment, membrane, Emulsion or cream kind, superfine powder.

6. vegetable composition according to claim 1 is for the preparation of the application in the medicine of delay skin aging or cosmetics.