CN103550511A - Plant composition capable of delaying skin aging, and preparation method thereof - Google Patents
Plant composition capable of delaying skin aging, and preparation method thereof Download PDFInfo
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- CN103550511A CN103550511A CN201310472551.3A CN201310472551A CN103550511A CN 103550511 A CN103550511 A CN 103550511A CN 201310472551 A CN201310472551 A CN 201310472551A CN 103550511 A CN103550511 A CN 103550511A
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- Cosmetics (AREA)
Abstract
The invention relates to a plant composition capable of delaying skin aging. The plant composition comprises extracts of the following raw materials by weight: 30-70 parts of radix asparagi, 10-50 parts of ginseng, 10-50 parts of grape seeds, 10-50 parts of Angelica sinensis, 10-50 parts of almonds, 10-50 parts of rhizoma polygonatum, 10-50 parts of radix ophiopogonis, 10-50 parts of radix astragali, 10-50 parts of bletilla striata, 10-50 parts of pria cocos and 10-50 parts of lily. The plant composition provided by the invention can play a role of delaying skin ageing and is safe in use.
Description
Technical field
The present invention relates to vegetable composition of a kind of delay skin aging and preparation method thereof, belong to cosmetic field.
Background technology
Skin is to safeguard human life and healthy pith, directly contacts with extraneous, and be the first barrier of body, be very easily subject to the impact of environmental factors and cause damaging.These are social in the changes of the aging of social population, the deterioration of environment and people's life habit etc., epochal character problem causes the problem of aging of skin to be on the rise, and people will more and more need when long, modulability and preventative skin care item efficiently.
Along with going deep into of medical research, consumers in general hold more careful attitude to the cosmetics of life-time service chemosynthesis material manufacture.Although the preparation that traditional Chinese herbal medicine is novel cosmetic provides wide raw material sources, also discovery is much strong to skin and mucous membrane irritation, easily produces the problems such as anaphylaxis.Therefore we should obtain and can tackle efficient, safe modulability, the nutrient composite matter that causes at present skin aging factor from comprising Chinese herbal medicine interior natural plants more widely.
Summary of the invention
Vegetable composition of the present invention is mainly comprised of the crude drug of following weight portion: Radix Asparagi 30-70 part, Radix Ginseng 10-50 part, Semen Vitis viniferae 10-50 part, Radix Angelicae Sinensis 10-50 part, Semen Armeniacae Amarum 10-50 part, Rhizoma Polygonati 10-50 part, Radix Ophiopogonis 10-50 part, Radix Astragali 10-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part, Poria 10-50 part, Bulbus Lilii 10-50 part.
Preferably, each crude drug and weight portion thereof are respectively: Radix Asparagi 40-60 part, Radix Ginseng 20-40 part, Semen Vitis viniferae 20-40 part, Radix Angelicae Sinensis 20-40 part, Semen Armeniacae Amarum 20-40 part, Rhizoma Polygonati 20-40 part, Radix Ophiopogonis 20-40 part, Radix Astragali 20-40 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Poria 20-40 part, Bulbus Lilii 20-40 part.
More preferably, each crude drug and weight portion thereof are respectively: 50 parts of Radix Asparagi, 30 parts of Radix Ginsengs, 30 parts of Semen Vitis viniferae, 30 parts of Radix Angelicae Sinensis, 30 parts, Semen Armeniacae Amarum, 30 parts of Rhizoma Polygonatis, 30 parts of Radix Ophiopogonis, 30 parts of the Radixs Astragali, 30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts, Poria, 30 parts of Bulbus Liliies.
The present invention also provides the preparation method of above-mentioned vegetable composition: various raw materials are mixed and are placed in extractor, with water or hydrophilic solvent extract, concentrated extracting solution and get final product.
Described hydrophilic solvent is ethanol, methanol, acetone, butanediol, propylene glycol or ethyl acetate etc.
Described extraction can be the methods such as decoction, reflux, extract,, merceration, percolation.
The present invention also provides a kind of galenical of being made by above-mentioned vegetable composition and excipient, and this galenical can be solution, ointment, membrane, Emulsion or cream kind, superfine powder.For example, in the concentrated solution of gained, add a certain amount of ethanol or polyhydric alcohol and appropriate antiseptic, can be made into solution.
The application of vegetable composition described in the present invention also provides in preparing medicine or cosmetics.
Beneficial effect
In above-mentioned formula, the effect that Radix Asparagi, Radix Ginseng, Semen Vitis viniferae have antioxidation, remove free radical, the destruction that stops the radical pair human skin cell of environmental pollution and radiation generation, delay skin aging, and Radix Asparagi has inhibitory action to multiple coccus and bacillus; Radix Angelicae Sinensis, can expand peripheral blood vessel, reduces vascular resistance, increases epidermis capillary blood circulation etc.; In Semen Armeniacae Amarum, contained fatty oil can make keratodermatitis softening, has the effects such as the skin protection of moisturizing; The Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Polygonati have antiinflammatory, the effect such as antibiotic; Poria, Bulbus Lilii have tranquilizing effect.
Each plant component fit applications of the present invention, can play following good effect:
1. improve cutaneous circulation, play promotion skin metabolism, improve the effect of cell viability;
2. radiation resistance, alleviates the negative effect that long-time office work causes skin;
3. antibiotic, moisturizing, removes free radical, alleviates the negative effect that operating pressure and environmental pollution cause skin;
4. pair skin, without any irritant reaction, is applicable to life-time service.
In sum, vegetable composition of the present invention can tackle various societies, the environmental factors that causes at present skin aging, skin aging has been play a part to delaying, and has used safety.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
Prescription forms: 70 parts of Radix Asparagi, 10 parts of Radix Ginsengs, 50 parts of Semen Vitis viniferae, 10 parts of Radix Angelicae Sinensis, 50 parts, Semen Armeniacae Amarum, 10 parts of Rhizoma Polygonatis, 50 parts of Radix Ophiopogonis, 10 parts of the Radixs Astragali, 50 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts, Poria, 150 parts of Bulbus Liliies.
The preparation method of vegetable composition of the present invention:
Each raw material is cleaned and is placed in extractor, add 4 times of amount deionized waters and decoct twice, each 30 minutes, after extracting liquid filtering is concentrated, obtain vegetable composition of the present invention.
Embodiment 2
Prescription forms: 30 parts of Radix Asparagi, 50 parts of Radix Ginsengs, 10 parts of Semen Vitis viniferae, 50 parts of Radix Angelicae Sinensis, 10 parts, Semen Armeniacae Amarum, 50 parts of Rhizoma Polygonatis, 10 parts of Radix Ophiopogonis, 50 parts of the Radixs Astragali, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 50 parts, Poria, 10 parts of Bulbus Liliies.
The preparation method of vegetable composition of the present invention:
Each raw material is cleaned and is placed in extractor, add 4 times of amount 75% alcoholic solution reflux, extract, twice, each 30 minutes, after extracting liquid filtering is concentrated, obtain vegetable composition of the present invention.
Embodiment 3
Prescription forms: 40 parts of Radix Asparagi, 40 parts of Radix Ginsengs, 20 parts of Semen Vitis viniferae, 40 parts of Radix Angelicae Sinensis, 20 parts, Semen Armeniacae Amarum, 40 parts of Rhizoma Polygonatis, 20 parts of Radix Ophiopogonis, 40 parts of the Radixs Astragali, 20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 40 parts, Poria, 20 parts of Bulbus Liliies.
The preparation method of vegetable composition of the present invention:
Each raw material is cleaned and is placed in extractor, add 4 times of amount 60% alcoholic solution reflux, extract, twice, each 30 minutes, after extracting liquid filtering is concentrated, obtain vegetable composition of the present invention.
Embodiment 4
Prescription forms: 60 parts of Radix Asparagi, 20 parts of Radix Ginsengs, 40 parts of Semen Vitis viniferae, 20 parts of Radix Angelicae Sinensis, 40 parts, Semen Armeniacae Amarum, 20 parts of Rhizoma Polygonatis, 40 parts of Radix Ophiopogonis, 20 parts of the Radixs Astragali, 40 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts, Poria, 40 parts of Bulbus Liliies.
The preparation method of vegetable composition of the present invention:
Each raw material is cleaned and is placed in extractor, add 4 times of amount methanol eddies and extract twice, each 30 minutes, after extracting liquid filtering is concentrated, obtain vegetable composition of the present invention.
Embodiment 5
Prescription forms:
50 parts of Radix Asparagi, 30 parts of Radix Ginsengs, 30 parts of Semen Vitis viniferae, 30 parts of Radix Angelicae Sinensis, 30 parts, Semen Armeniacae Amarum, 30 parts of Rhizoma Polygonatis, 30 parts of Radix Ophiopogonis, 30 parts of the Radixs Astragali, 30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts, Poria, 30 parts of Bulbus Liliies.
The preparation method of vegetable composition of the present invention:
Each raw material is cleaned and is placed in extractor, add 4 times of amount acetone reflux, extract, twice, each 30 minutes, after extracting liquid filtering is concentrated, obtain vegetable composition of the present invention.
Embodiment 6
Get the vegetable composition of embodiment 1 gained, add water and propylene glycol, make the solution containing propylene glycol 30%, after filtering, adding preservative agent obtains solution a.The concentration of this solution is calculated as 1.5 grams per milliliters according to every milliliter contained amount.
Embodiment 7
Get the vegetable composition of embodiment 1 gained, add water and 1,3 one butanediol, make the solution containing 1,3 one butanediol 30%, after filtering, adding preservative agent obtains solution b.The concentration of this solution is calculated as 1.5 grams per milliliters according to every milliliter contained amount.
Embodiment 8
The test of rabbit skin irritation
The solution of test specimen: embodiment 6 gained
Test method: with reference to < < cosmetics health standard > > (2007 editions)
Experimental animal: white rabbit
Experimental result: skin irritation test in 7 days, has no irritant reaction.
Embodiment 9
Antioxidation test
Embodiment 1 extract and Semen Vitis viniferae extract are removed the comparison of free radical ability: get embodiment 1 compositions of equivalent and the extract of Semen Vitis viniferae and do respectively its antioxidant effect of removing free radical experimental evaluation, experimental data is known table 1:
Table 1 present composition antioxidant effect
It can be seen from the table embodiment 1 extract is removed free radical ability, far away higher than the extract of single Semen Vitis viniferae.
Embodiment 10
Clinical effectiveness
1, clinical data:
Selection meets women's 60 examples of skin aging standard, 28～35 years old age.Be divided at random test group 32 examples, matched group 28 examples.
2, skin aging standard:
Skin aging main manifestations is: dry, coarse, and desquamation, microgroove, shallow complexion, irregular pigment alteration, the sensitivity of skin increases, and elasticity reduces.Getting rid of skin of face has erosion, vesicle and breakage, and high susceptibility skin, has long-term chemical substance contact history and cause for a long time skin allergy and Pigmented medicinal application history.
3, method:
Test group: sooner or later after clean, the solution that above-described embodiment 6 is made is evenly applied in skin of face and carries out appropriate time massage.Be 2 months the course for the treatment of.
Matched group: sooner or later after clean, evenly smear the blank solvent of adding in above-described embodiment 6, i.e. 30% aqueous solution of propylene glycol in face.Be 2 months the course for the treatment of.
Two groups are respectively carried out symptom score 1 time by special messenger before and after treatment.
4, female face skin aging quantizes standards of grading:
1. coarse, dry: with tactile rough of buccal, forehead, mouthful Zhou Youyi place position skin, to be designated as 1 minute; With buccal, forehead, mouth, there is the companion's desquamation that is in the way that touch at the tactile rough or position, place of two position, place skins to be designated as 2 minutes in week; That with buccal, forehead, mouthful Zhou Chu position skin, touches is all rough or be greater than the companion's desquamation that is in the way that position, a place skin touches and be designated as 3 minutes.
2. fine wrinkle: there is shallow thin crows-feet at place, canthus, and the plain wrinkle person of forehead is designated as 1 minute; Place, canthus, forehead, the thick tail stricture of vagina person of buccal portion are designated as 2 minutes; Place, canthus, forehead, buccal portion, mouthful all places and cervical region have obvious wrinkle person to be designated as 3 minutes.
3. irregular pigment alteration: only take buccal as main, area is no more than the more than 30% of whole face, and paler colour, is filbert, is dispersed in distribution and does not merge in flakes, is designated as 1 minute; With two cheeks, forehead, have brown spot, area surpasses the more than 50% of whole face, and the color of speckle is darker, is dark brown, and fusion is designated as 2 minutes in flakes; With positions such as forehead, ,Bi both sides, buccal, lip weeks, have the deep brown spot being dispersed in, the 70% above person that area accounts for whole face is designated as 3 minutes.
4. the complexion firefly that withers: shallow complexion is glossy is designated as 1 minute, and ochriasis tarnish is designated as 2 minutes, complexion is withered and yellow dark and gloomyly to be had no gloss and is designated as 3 minutes.
5. skin elasticity: can recover rapidly after pressing but around producing more wrinkle is designated as 1 minute in press section; Skin elasticity is not good enough, and after pressing, 1～2s can recover to be designated as 2 minutes; Skin elasticity is poor, and after pressing, surpassing 2s can recuperator be designated as 3 minutes.
5, efficacy assessment standard:
Score value * 100% before symptom integral score value improvement rate=(the rear symptom integral score value of symptom integral score value one treatment before treatment)/treatment.
Effective: symptom integral value reduces >=70%; Effective: symptom integral value reduces >=50%; Invalid: symptom has no obvious improvement or instead sees deterioration, and symptom integral value reduces <50%.
6, result
Before and after two groups of treatments, clinical symptoms integral contrast is in Table 2.
Clinical symptoms integral contrast before and after the treatment of table 2.2 group (
minute)
Two groups of curative effects are relatively in Table 3.
The comparison of table 3.2 group curative effect
Claims (9)
1. the vegetable composition of a delay skin aging, it is characterized in that, the extract that its component is following raw materials in part by weight is made: Radix Asparagi 30-70 part, Radix Ginseng 10-50 part, Semen Vitis viniferae 10-50 part, Radix Angelicae Sinensis 10-50 part, Semen Armeniacae Amarum 10-50 part, Rhizoma Polygonati 10-50 part, Radix Ophiopogonis 10-50 part, Radix Astragali 10-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part, Poria 10-50 part, Bulbus Lilii 10-50 part.
2. vegetable composition according to claim 1, it is characterized in that, the weight portion of each crude drug is respectively: Radix Asparagi 40-60 part, Radix Ginseng 20-40 part, Semen Vitis viniferae 20-40 part, Radix Angelicae Sinensis 20-40 part, Semen Armeniacae Amarum 20-40 part, Rhizoma Polygonati 20-40 part, Radix Ophiopogonis 20-40 part, Radix Astragali 20-40 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Poria 20-40 part, Bulbus Lilii 20-40 part.
3. vegetable composition according to claim 2, it is characterized in that, the weight portion of each crude drug is respectively: 50 parts of Radix Asparagi, 30 parts of Radix Ginsengs, 30 parts of Semen Vitis viniferae, 30 parts of Radix Angelicae Sinensis, 30 parts, Semen Armeniacae Amarum, 30 parts of Rhizoma Polygonatis, 30 parts of Radix Ophiopogonis, 30 parts of the Radixs Astragali, 30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts, Poria, 30 parts of Bulbus Liliies.
4. the preparation method of the vegetable composition as described in claim 1 to 3 arbitrary, is characterized in that, described raw extract is the extract of water or hydrophilic solvent.
5. the preparation method of vegetable composition as claimed in claim 4, is characterized in that, various raw materials are mixed and are placed in extractor, with water or hydrophilic solvent extract, concentrated extracting solution and get final product.
6. the preparation method of vegetable composition as claimed in claim 5, is characterized in that, described hydrophilic solvent is ethanol, methanol, acetone, butanediol, propylene glycol or ethyl acetate.
7. with the vegetable composition of delay skin aging, it is characterized in that, its arbitrary described vegetable composition and excipient by claim 1 to 3 is made.
8. vegetable composition as claimed in claim 7, is characterized in that, it is solution, ointment, membrane, Emulsion or cream kind, superfine powder.
9. arbitrary described vegetable composition of claim 1 to 3 is in the medicine for the preparation of delay skin aging or the application in cosmetics.
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| CN106309911A (en) * | 2016-08-19 | 2017-01-11 | 上海家化联合股份有限公司 | Anti-ageing traditional Chinese medicine composition and preparation method thereof |
| CN109010223A (en) * | 2018-07-18 | 2018-12-18 | 吕向阳 | A kind of high stability preparation for external application to skin and preparation method and application |
| CN113876883A (en) * | 2021-10-21 | 2022-01-04 | 中国人民解放军空军军医大学 | Novel medicament for resisting ultraviolet injury in battle special environment and preparation method thereof |
| CN115192502A (en) * | 2022-07-01 | 2022-10-18 | 大理白族自治州中药制药有限公司 | A rhizoma Polygonati skin care cosmetic prepared from rhizoma Polygonati and its preparation method |
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| CN101829038A (en) * | 2010-05-17 | 2010-09-15 | 广东养美医药投资有限公司 | Winkle-removing Chinese medicament facial mask and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309911A (en) * | 2016-08-19 | 2017-01-11 | 上海家化联合股份有限公司 | Anti-ageing traditional Chinese medicine composition and preparation method thereof |
| CN106309911B (en) * | 2016-08-19 | 2021-01-22 | 上海家化联合股份有限公司 | Anti-aging traditional Chinese medicine composition and preparation method thereof |
| CN109010223A (en) * | 2018-07-18 | 2018-12-18 | 吕向阳 | A kind of high stability preparation for external application to skin and preparation method and application |
| CN113876883A (en) * | 2021-10-21 | 2022-01-04 | 中国人民解放军空军军医大学 | Novel medicament for resisting ultraviolet injury in battle special environment and preparation method thereof |
| CN113876883B (en) * | 2021-10-21 | 2022-09-09 | 中国人民解放军空军军医大学 | Novel medicament for resisting ultraviolet damage in battle-specific environment and preparation method thereof |
| CN115192502A (en) * | 2022-07-01 | 2022-10-18 | 大理白族自治州中药制药有限公司 | A rhizoma Polygonati skin care cosmetic prepared from rhizoma Polygonati and its preparation method |
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| CN103550511B (en) | 2016-03-23 |
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