CN103099774B - Chinese medicine composition and application thereof - Google Patents

Chinese medicine composition and application thereof Download PDF

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CN103099774B
CN103099774B CN201310079544.7A CN201310079544A CN103099774B CN 103099774 B CN103099774 B CN 103099774B CN 201310079544 A CN201310079544 A CN 201310079544A CN 103099774 B CN103099774 B CN 103099774B
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mineral matter
water extract
natural mineral
matter water
skin
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CN103099774A (en
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胡永志
龙致科
覃青云
黄华来
王韧
方堃
韦日平
黎昌健
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ANHUI LIANGMIANZHEN FANGCAO DAILY CHEMICALS Co Ltd
LIANGMIANZHEN (YANGZHOU) HOTEL PRODUCTS CO Ltd
LIUZHOU LMZ CO Ltd
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ANHUI LIANGMIANZHEN FANGCAO DAILY CHEMICALS Co Ltd
LIANGMIANZHEN (YANGZHOU) HOTEL PRODUCTS CO Ltd
LIUZHOU LMZ CO Ltd
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Abstract

The invention discloses a kind of Chinese medicine composition and application thereof, Chinese medicine composition of the present invention is by Camellia nitidissima Chi subset natural mineral matter water extract, Semen Vitis viniferae subset natural mineral matter water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular group's natural mineral matter water extract, Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract are mixed to get, Chinese medicine composition of the present invention may be used for flesh and to slip pale skin external preparation, can multi-direction synthetic effect skin, and functional component is penetrated epidermis implantation skin containing natural small molecule group implant, to skin, there is obvious whitening simultaneously, crease-resistant, the multiple effects such as moisturizing, this natural Chinese medicine composition can reduce the zest of external preparation, strengthen the protective effect to skin, also have safe and reliable, advantage simple for production.

Description

Chinese medicine composition and application thereof
Technical field
The present invention relates to technical field of skin care, especially a kind ofly to slip the Chinese medicine composition of white implantation composition and application thereof containing natural flesh.
Background technology
In Asia, have the symbol that fair skin is considered to beautiful, and believe that the Chinese of " ugly white screening hundred " have the pursuit to whitening from ancient times; The beauty of skin is the topic of woman's invariability, allow oneself the skin moment water profit, pale, smooth, be the tidemark of each Chinese woman's unremitting pursue of liking to be beautiful; Along with the epoch are progressive; living standards of the people improve, and the requirement of people to skin is more and more higher, more and more focuses on the maintenance of skin; and good whitening and anti-aging skin care product can help woman better to protect skin; reduce extraneous factor to the injury of skin, delaying skin aging, make skin recover elasticity; mould without wrinkle, without the lax tender skin of water; make woman more self-confident, beautiful, in the skin care product market of China, whitening and anti-wrinkle product occupy the share of 85%.
Hurry green life in city, air pollution, ultraviolet irradiation, age increases, stay up late, the skin moment of woman is allowed to be damaged, occur that the colour of skin is obscure, xerosis cutis and increase the weight of skin texture and cause wrinkle, conventional whitening additive is vitamin C at present, kojic acid, arbutin etc., antidotal agent is vitamin E, vitamin A, fruit acid etc., these materials are not because chemical constitution is unstable, easily be subject to light, heat, the factor impacts such as oxygen, directly be difficult to apply in skin care item, be exactly that great majority are for macromolecular substances, be not easy to be absorbed by the skin, and there is low irritant, easily cause skin allergy, add grievous hurt skin, and action pathway is single, DeGrain, so people extremely need use safety, energy multidigit stereo synthesis effect skin, the skin-protection product of Be very effective.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of containing natural small molecule group implant, functional component is implanted skin, skin is had to obvious whitening, crease-resistant, moisturizing and the Chinese medicine composition of use safety.
Another technical problem to be solved by this invention is to provide the application of above-mentioned Chinese medicine composition.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
This Chinese medicine composition is mixed to get by following component: Camellia nitidissima Chi subset natural mineral matter water extract, Semen Vitis viniferae subset natural mineral matter water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular group's natural mineral matter water extract, Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract, the described Camellia nitidissima Chi subset natural mineral matter water extract of the Chinese medicine composition described in composition, Semen Vitis viniferae subset natural mineral matter water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular group's natural mineral matter water extract, the weight ratio of Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract is 2:1:1:1:1:1, these six kinds of described extracts and respective former medicine weight ratio are 10:1.
The application of above-mentioned Chinese medicine composition on preparation skin-whitening anti-wrinkle agent.
In whitening anti-wrinkling skin preparations for extenal use of the present invention, except above-mentioned essential component, the composition that cooperation that can be suitable as required uses usually in skin care item, as matrix components such as butanediol, glycerol, polydimethylsiloxane, the weight ratio of this Chinese medicine composition in skin preparations for extenal use is 2 ~ 22%.
The dosage form of skin-whitening anti-wrinkle agent is not particularly limited, and can be solution, suspension, as lotion; Can be emulsion, milk, as milky lotion; Can be gel, paste, as emollient cream etc.
Camellia nitidissima Chi of the present invention, belongs to plant of theaceae, the nontoxic level of JINHUA Camellia, containing 400 multiple nutrients materials, to have no side effect; Be rich in the multiple natural nutrition compositions such as tea polysaccharide, tea polyphenols, Total saponin, total flavones, tea pigment, protein, vitamin B1, B2, vitamin C, vitamin E, folic acid, fatty acid, B-carotene; Camellia nitidissima Chi contains tens seed amino acid such as theanine, threonine; Camellia nitidissima Chi is one of plant that occurring in nature is medicinal, nutritive value is the abundantest.
Semen Vitis viniferae of the present invention, the generation and the recoverin matter that are conducive to collagen protein are active, and effective scavenging free radicals keeps skin submissive, smooth, postpones or reduce the appearance of wrinkle; Strengthen skin resistance, immunity, control skin allergy and all kinds of dermatosis; Strengthen skin capability of resistance to radiation, stop ultraviolet damage; The release that cell fundamentally suppresses sensitizing factor " histamine " can be goed deep into, improve cell to the toleration of anaphylactogen; Remove sensitization free radical, antiinflammatory, antiallergic; Stablize skin heart tissue.
The Pseudobulbus Bletillae (Rhizoma Bletillae) of the present invention, belong to orchid, rich in starch, glucose, volatile oil, phlegmatic temperament etc., external is embrocated, and can eliminate the vestige that acne on the face stays, and makes skin smooth seamless; Tang Materia Medica is recorded in addition: " brothers' chap is torn open, chews to be coated with it." and rhagadia manus et pedis is controlled in " Ji anxious celestial being side " record: Pseudobulbus Bletillae (Rhizoma Bletillae) is last, and water withers plug, does not violate water; The Pseudobulbus Bletillae (Rhizoma Bletillae) is to prevention xerosis cutis and good effect of having chapped.
Radix Glycyrrhizae of the present invention, belong to leguminous plant, Li Shizhen (1518-1593 A.D.) released in Compendium of Material Medica: " in all medicines, Radix Glycyrrhizae be monarch, controls 72 kinds of mammary calculus poison, and separate 1,002 BAICAO wood malicious, many medicines that is in harmonious proportion are meritorious, thus have ' state is old ' number." application Radix Glycyrrhizae extract can reduce the stimulation of skin-care product base to skin, effectively remove the toxin in Skin Cell, keep skin health.
Radix Angelicae Sinensis of the present invention implants adjuvant as functional component, has effect of invigorating blood circulation of enriching blood, and energy skin expansion pericellular blood vessel, increase circulating liquid measure, thus quickening effect enters skin, is conducive to penetration enhancement.
The solvent that the present invention is used for plant extract is subset natural mineral matter water, bar Ma Tianrankuangwuzhishui can be used, special product, in Bama Area In Guangxi, belongs to the pure natural subset clustered water that the world is very rare, has extremely strong penetration, extension, dissolving power and metabolism power, more easily by cell, increase the exchange of intraor extracellular water, scavenging free radicals, noxious acidic metabolite, promote the growth of cell, growth, keep the vitality of cell; Nobel Prize in medicine and physiology encourage winner Germany scientist Dr.ErwinNeher and Dr.BertSakmann result of study shows: only have small-micelle water just by the human body cell ion channel of 2 nanometers, enter nucleus and DNA, activating cell enzyme tissue, excites vitality.Bar horse natural small molecule group water, as the main implant of functional component, can not destroy skin histology ecological balance, helps whitening, the functional component skin permeation epidermis such as crease-resistant enters cell tissue, be conducive to functional component and play maximum effect.
Owing to have employed technique scheme, the present invention compared with prior art, has following beneficial effect:
Because this Chinese medicine composition contains the abundantest Camellia nitidissima Chi subset natural mineral matter water extract of nutritional labeling, have and can remove sensitization free radical, antiinflammatory antianaphylactic Semen Vitis viniferae subset natural mineral matter water extract, xerosis cutis can be prevented, the Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract of chapping, toxin in effective removing Skin Cell, keep the Radix Glycyrrhizae subset natural mineral matter water extract of skin health, there is effect of invigorating blood circulation of enriching blood, energy skin expansion pericellular blood vessel, increase circulating liquid measure, thus accelerate effect and enter skin and be conducive to sorbefacient Chinese-Angelica micromolecular group natural mineral matter water extract and Ganoderma subset natural mineral matter water extract, thus can multi-direction synthetic effect skin, and the natural small molecule contained group implant, functional component is penetrated epidermis and implant skin, to skin, there is obvious whitening simultaneously, crease-resistant, the multiple effects such as moisturizing, this natural Chinese medicine composition can reduce the zest of skin care item, strengthens the protective effect to skin, also have safe and reliable, advantage simple for production.
Specific embodiment
Below in conjunction with specific embodiment, the invention will be further described, but technical scope of the present invention does not limit by these embodiments.All proportional quantities are calculated all by weight percentage below.
Composed as follows containing the slip Chinese medicine composition of white implantation composition of natural flesh:
The weight ratio of Camellia nitidissima Chi subset natural mineral matter water extract, Semen Vitis viniferae subset natural mineral matter water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular group natural mineral matter water extract, Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract is 2:1:1:1:1:1; Be 2 ~ 22% containing the slip weight ratio of Chinese medicine composition in skin preparations for extenal use of white implantation composition of natural flesh.
The application of Chinese medicine composition in lotion:
Table 1: each constitutive material and weight percent content in embodiment 1 to embodiment 3
The application of Chinese medicine composition in milky lotion:
Table 2: each constitutive material and weight percent content in embodiment 4 to embodiment 6
The application of Chinese medicine composition in emollient cream:
Table 3: each constitutive material and weight percent content in embodiment 7 to embodiment 9
Clinical trial:
1, whitening clinical trial:
(1) experimenter's selection standard
1. 25-40 years old ages, non-allergic constitution, not irritated to skin care item, medicine; 2. skin belongs to normal condition, and health is normal.
(2) whitening clinical trial
Subjects, totally 90 examples.Wherein man 30 example, female 60 example, 25-40 years old ages.90 examples are met the object of tested standard by man: female is about 1:2 and is divided into 3 test group at random, often organize 30 examples, be respectively used to the whitening effect of testing example 4,5,6 milky lotion.Age of each test group, sex, melanin index (before test), through statistical test P > 0.05, have comparability.
In right-hand man's forearm, upside is tried out, and every day, each use sooner or later 1 time, avoided after smearing being washed.In the left arm of each test group personnel, upside smears the milky lotion of embodiment 4,5,6 respectively, blank (the blank milky lotion of the white Chinese medicine composition that do not slip containing flesh) is made with upside correspondence position in right arm, respectively before on probation, within 4 weeks on probation, 8 weeks on probation, test and try out position dermal melanin index, the German CK company SkinAnalyzerSHM100 skinanalysis apparatus of test instrunment.Left and right arms is to taking 6 tests, and test result gets arithmetic mean of instantaneous value, investigates practical effect by data.
Clinical test results proves, twice daily, use 4 weeks continuously, by clinical examination and statistical analysis, black number index significantly reduces service test group milky lotion, service test group milky lotion 4 weeks is described, has obvious whitening function to human body skin.
2, wrinkle removal clinical trial:
(1) wrinkle of skin situation classification
According to Glogau typing, classification is carried out, in table 5 to wrinkle of skin
(2) experimenter's selection standard
1. wrinkle of skin grade scale is met; 2. 30-70 years old ages, non-allergic constitution, not irritated to skin care item, medicine and silica gel; 3. skin of face NAI, without photosensitivity or dermatosis, not with reduce wrinkle method persons such as laser; 4. skin belongs to normal condition, and health is normal.
(3) wrinkle grade and integral estimation
Under unified standard conditions, all take the region (A district) between outer canthus to hairline and forehead photo before and after test, evaluate by the wrinkle on the standard control sheet worked out in advance.Then the A district of two photos and forehead before and after viewing test, and record wrinkle quantity, the degree of depth, the length in two regions.Wrinkle integration is by every bar wrinkle depth score value (d) in A district and forehead position and the product accumulation of length score value (l) with wrinkle number score value (n) in each region, the wrinkle that each region selects 5 score values maximum respectively, gets the meansigma methods of two domain integrals.
(4) wrinkle removal clinical trial
Subjects, totally 120 examples.Wherein man 60 example, female 120 example, 30-70 years old ages.180 examples are met the object of tested standard by man: female is about 1:2 and is divided into 3 test group and 1 matched group at random, often organize 30 examples.Age of each test group and its matched group, sex, wrinkle degree (before test), through statistical test P > 0.05, have comparability.
3 test group use emollient cream of embodiment 7,8,9 respectively, and matched group uses the blank emollient cream of the white Chinese medicine composition that do not slip containing flesh, and be coated with respectively at outside wrinkle of skin test position, every day is respectively coated with 1 time sooner or later, avoids being washed after smearing.Before on probation, 4 weeks on probation, try out and all carry out wrinkle of skin grade and integral estimation in 8 weeks.
Clinical test results proves, twice daily, continuously use 4 weeks, by clinical examination and statistical analysis, wrinkle integration significantly reduces service test group emollient cream, and service test group emollient cream 4 weeks are described, has obvious dispel effect to wrinkle of skin.Simultaneously along with the increase of Chinese medicine ingredients and the prolongation of service time, wrinkle removal effect is strengthened.

Claims (2)

1. a Chinese medicine composition, it is characterized in that it is mixed to get by following component: Camellia nitidissima Chi subset natural mineral matter water extract, Semen Vitis viniferae subset natural mineral matter water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular group's natural mineral matter water extract, Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract, the described Camellia nitidissima Chi subset natural mineral matter water extract of the Chinese medicine composition described in composition, Semen Vitis viniferae subset natural mineral matter water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular group's natural mineral matter water extract, the weight ratio of Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract is 2:1:1:1:1:1, these six kinds of described extracts and respective former medicine weight ratio are 10:1.
2. the application of Chinese medicine composition according to claim 1 on preparation skin-whitening anti-wrinkle agent.
CN201310079544.7A 2012-08-02 2013-03-13 Chinese medicine composition and application thereof Active CN103099774B (en)

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CN102764218A (en) * 2012-08-02 2012-11-07 柳州两面针股份有限公司 Traditional Chinese medicine composition and applications thereof
CN106038464A (en) * 2016-07-11 2016-10-26 佛山杰致信息科技有限公司 Composite anti-wrinkle skin care product and preparation method thereof
CN106726889A (en) * 2016-12-02 2017-05-31 广西中港高科国宝金花茶产业有限公司 The extracting method of Camellia nitidissima active ingredient and prepare the purposes of health products
CN106727219A (en) * 2016-12-02 2017-05-31 广西中港高科国宝金花茶产业有限公司 The production method of golden flower tea facial masks
CN106726891A (en) * 2016-12-02 2017-05-31 广西中港高科国宝金花茶产业有限公司 The production method of Camellia nitidissima shower cream
CN106726890A (en) * 2016-12-02 2017-05-31 广西中港高科国宝金花茶产业有限公司 The production method of Camellia nitidissima shampoo
CN106491498A (en) * 2016-12-02 2017-03-15 广西中港高科国宝金花茶产业有限公司 The production method of Camellia nitidissima Chi protective skin cream

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CN101467941A (en) * 2007-12-27 2009-07-01 天津天阜康生物技术发展有限公司 Chinese medicine mask with whitening and spot-eliminating functions and technique for preparing the same
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