CN111110624A - Whitening composition - Google Patents

Whitening composition Download PDF

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Publication number
CN111110624A
CN111110624A CN202010029276.8A CN202010029276A CN111110624A CN 111110624 A CN111110624 A CN 111110624A CN 202010029276 A CN202010029276 A CN 202010029276A CN 111110624 A CN111110624 A CN 111110624A
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parts
extract
whitening composition
oil
weight
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陈正雄
陈佳琦
陈玉倩
黄瑞盛
欧宜芬
吕梨萍
周琦
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Jourdeness Guangzhou Cosmetics Co ltd
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Jourdeness Guangzhou Cosmetics Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a whitening composition which comprises ascorbyl glucoside, an alteromonas fermentation product extract, a yeast extract and a sophora flower extract. The whitening composition is added with ascorbyl glucoside, an alteromonas fermentation product extract, a yeast extract and a sophora flower extract, and the whitening effect can be realized from inside to outside by matching the components. The invention also discloses cream, aqua or emulsion containing the whitening composition.

Description

Whitening composition
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a whitening composition.
Background
Smooth, fair and ruddy skin is always the beauty fashion pursued by oriental women, and the effects of 'skin like snow and skin like grease' are hopefully achieved. In the past, people often use whitening products containing physical shielding raw materials such as titanium dioxide and the like, and can temporarily whiten and modify own skin. With the advancement of technology, today women seek whitening with a deeper physiological need, seek whitening of the whole skin, such as lightening, removing and preventing pigmentation, and simultaneously require whitening products with safe, mild and efficient properties.
The tyraminidase has unique dual catalytic functions and is a key enzyme for melanin synthesis in organisms. Arbutin, vitamin C derivatives, kojic acid and derivatives thereof in commercially available whitening cosmetics mainly inhibit tyrosinase activity to inhibit melanin synthesis and further whiten skin. Many component canes are available on the market to inhibit tyrosinase for whitening, but the inhibited tyrosinase is still present.
But the whitening products on the market are really less effective in whitening.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a whitening composition.
In order to achieve the purpose, the invention adopts the technical scheme that: a whitening composition comprises ascorbyl glucoside, alteromonas ferment extract, yeast extract and sophora flower extract.
The whitening composition disclosed by the invention is added with SOPHORA JAPONICA (Sophora JAPONICA) flower extract, wherein the extract contains 3' -hydroxy genistein, so that tyrosinase can be dormant. Vitamin C can inhibit abnormal pigmentation of skin, also can inhibit melanin production in skin, has functions of reducing and synthesizing melanin and lightening pigment, and ascorbyl glucoside can activate enzyme in living body in cell to release vitamin C, and is a whitening component with continuous effect; the alteromonas fermentation product extract and the yeast extract can strengthen skin metabolism, improve the barrier function of skin and achieve the effect of resisting air pollution. Therefore, the combination of the ascorbyl glucoside, the alteromonas fermentation product extract, the yeast extract and the sophora flower extract can realize the whitening effect from inside to outside.
Preferably, the whitening composition comprises the following components in parts by weight: 0.005-0.02 part of ascorbic acid glucoside, 0.01-0.06 part of alteromonas fermentation product extract, 0.001-0.005 part of yeast extract and 0.002-0.006 part of sophora flower extract. The components can be better matched with each other in the proportion, and the whitening effect is better.
Preferably, the whitening composition also comprises 0.05-0.2 part of a water lily flower extract, 0.01-0.1 part of a slender yellow-heart root extract and 0.001-0.02 part of a grape juice extract.
The water lily flower (NYMHAEA ALBA) extract contains proline, is grafted with palmitoyl to improve skin-friendly property, is easier to be absorbed by skin, contains natural high-efficiency plant-based sedative and anti-allergy, and achieves the effects of protecting DNA, relieving inflammation reaction and strengthening skin tissues by removing free radicals, inhibiting activities of cyclooxygenase (cyclooxygenase), Elastase (Elastase) and Hyaluronidase (Hyaluronidase), and can be used for treating melanin pigmentation caused by inflammation stimulation and has the effect of lightening melanin. The extract of Boerhavia differusa root is rich in hydroxybenzene complex, and has effects of inhibiting in vivo inflammation signal transmission, preventing allergy deterioration, relieving various discomfort, and effectively achieving anti-allergy repairing effect. The grape juice extract is rich in polyphenols, and the resveratrol is converted into delta-grape essence-resveratrol derivatives by a biological enzyme catalysis technology, so that the anti-aging effect can be achieved by permeating skin, the synthesis of collagen I can be promoted, and the anti-wrinkle effect can be achieved. The white water lily flower extract and the yellow slender core extract are matched to improve the whitening effect, and the effects of relieving, anti-allergy and anti-aging can be achieved.
Preferably, the whitening composition further comprises 3-8 parts by weight of CAMELLIA OLEIFERA (CAMELLIA OLEIFERA) seed oil. The oil tea seed oil contains oleic acid with a content of over 86 percent, is more easily accepted by skin, contains rich acid ester glycerin, camellin, theasapogenol, protein and vitamin A, E, and has the effects of moisturizing, reconstructing and recovering skin, strengthening skin health and preventing wrinkles.
Preferably, the whitening composition further comprises 0.005-0.02 parts by weight of wild soybean (GLYCINE SOJA) oil.
Preferably, the whitening composition further comprises niacinamide, fullerene and squalane.
Fullerene has effects of strongly removing free radicals generated by ultraviolet, protecting cells, resisting aging, effectively reducing melanin generation, inhibiting anaphylaxis of giant cells, and resisting inflammation. The combination of the nicotinamide, the fullerene and the squalane can repair skin barriers, lighten melanin and achieve the effect of deep whitening.
Preferably, the whitening composition further comprises 0.5-2 parts by weight of niacinamide, 0.00005-0.0001 part by weight of fullerene and 0.1-1 part by weight of squalane.
Preferably, the whitening composition further comprises the following components in parts by weight: 2.5 to 3 parts of cyclopentadimethylsiloxane, 1.5 to 2 parts of polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, 0.3 to 0.8 part of polydimethylsiloxane, 3 to 8 parts of 1, 3-propylene glycol, 1.5 to 3.5 parts of glycerol, 0.05 to 0.2 part of glycerol polyacrylate, 0.5 to 1.5 parts of glycerol acrylate/acrylic acid copolymer, 0.1 to 0.3 part of propylene glycol, 0.1 to 0.3 part of PVM/MA copolymer and 1 to 3 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, 0.1-1 part of mineral oil, 60.05-1.5 parts of tridecyl alcohol polyether, 0.5-2 parts of butanediol, 0.005-0.02 part of hydrogenated lecithin, 0.005-0.02 part of sodium oleate, 0.005-0.02 part of EDTA disodium, 0.5-2 parts of isotridecanol isononanoate, 0.1-0.6 part of sodium palmitoyl prolinate, 0.3-1 part of dipropylene glycol, 0.01-0.2 part of o-cymene-5-ol and 0.03-0.1 part of xanthan gum. The cream prepared from the components in the ratio has stable property.
Preferably, the whitening composition further comprises the following components in parts by weight: 2 to 10 parts of 1, 3-propylene glycol, 2 to 10 parts of PPG-3 benzyl ether myristate, 2 to 10 parts of glycerol, 1 to 5 parts of coconut oil alcohol-caprylate/caprate, 0.5 to 2 parts of butanediol, 0.005 to 0.02 part of hydrogenated lecithin, 0.005 to 0.02 part of sodium oleate, 0.01 to 0.1 part of EDTA disodium, 0.5 to 2 parts of glycerol stearate, 0.3 to 1 part of PEG-100 stearate, 0.5 to 2 parts of cetearyl alcohol and 0.5 to 2 parts of polydimethylsiloxane, 0.1-0.5 part of glycerol stearate, 0.1-0.5 part of behenyl alcohol, 0.05-0.3 part of palmitic acid, 0.05-0.3 part of stearic acid, 0.01-0.1 part of lecithin, 0.01-0.1 part of lauryl alcohol, 0.01-0.1 part of myristyl alcohol, 0.01-0.1 part of cetyl alcohol, 210.5-1 part of steareth-210.5 parts of ammonium acryloyldimethyl taurate/VP copolymer, 20.3-0.8 part of steareth-20.3 parts of palmityl prolinate, 0.1-0.6 part of palmityl prolinate and 0.3-1 part of dipropylene glycol. The cream prepared from the components in the ratio has stable property.
Preferably, the whitening composition further comprises an excipient.
The invention also aims to provide a cream, aqua or emulsion containing the whitening composition.
The invention has the beneficial effects that: the invention provides a whitening composition, which is added with ascorbyl glucoside, an alteromonas fermentation product extract, a yeast extract and a sophora flower extract, and the whitening effect can be realized from inside to outside by matching the components.
Drawings
FIG. 1 shows the results of the patch test.
Detailed Description
The raw materials in the examples and comparative examples of the present invention were purchased from the market.
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
The whitening composition of the embodiment comprises the following components in percentage by weight: alteromonas ferment product extract 0.021%, SOPHORA JAPONICA (SOPHORA JAPONICA) flower extract 0.004%, yeast ferment product extract 0.002%, ascorbyl glucoside 0.01%, CAMELLIA OLEIFERA (CAMELLIA OLEIFERA) seed oil 5%, GLYCINE SOJA (GLYCINE SOJA) oil 0.01%, grape (VITIS VINIFERA) juice extract 0.005%, BOERHAVIA difrosa (BOERHAVIA difrosa) root extract 0.0125%, water lily (NYMPHAEA ALBA) flower extract 0.05%, 1, 3-propanediol 6.82%, PPG-3 benzyl ether myristate 5%, glycerol 5%, coco-caprylate/caprate 3%, butanediol 1.27%, lecithin hydride 0.01%, sodium oleate 0.01%, disodium EDTA 0.06%, glycerol stearate 1.17%, PEG-100 stearate 0.6%, capryl hydroximate 0.91%, 1, 2-hexanediol 0.42%, cetyl alcohol 1%, dimethicone, behenyl alcohol 27%, behenyl alcohol 0.27%, behenyl alcohol 0.15%, and mixtures thereof, Palmitic acid 0.16%, stearic acid 0.14%, lecithin 0.04%, lauryl alcohol 0.04%, myristyl alcohol 0.04%, cetyl alcohol 0.04%, steareth-210.75%, ammonium acryloyldimethyl taurate/VP copolymer 0.7%, steareth-20.5%, sodium palmitoyl prolinate 0.1575%, dipropylene glycol 0.28%, o-cymene-5-ol 0.09%, sweet orange (CITRUS AURANTIUMDULCIS) peel oil 0.023%, CITRUS (CITRUS RETICULATA) peel extract 0.007%, basil (ocillicum) oil 0.0029%, spearmint (mas MENTHA SPICATA) flower/leaf/stem extract 0.001%, ROSA DAMASCENA (ROSA davurica) flower oil 0.001%, CITRUS GRANDIS (CITRUS GRANDIS) peel oil 0.001%, ROSA rugosa (cyogoni) oil 0.001%, ROSA rugosa (caryophylli) flower oil 0.002%, euphorbia heterophylla OFFICINALIS (balm grandiflora) flower oil 0.001%, euphorbia OFFICINALIS (sage GRANDIS) flower oil 0.02%, euphorbia OFFICINALIS (sage grandiflora) flower oil 0.002%, euphorbia grandiflora (sage) flower oil 0.001%, euphorbia OFFICINALIS (sage) flower oil 0.001%, sage flower oil 0.002%, sage (artemisia GRANDIS) fruit oil 0.001%, sage (artemisia grandiflora 0.001%, sage flower oil 0.02%, sage flower oil (sage) fruit oil 0.002%, sage oil (sage oil 0.001%, sage flower oil (sage, 0.005% of sodium hydroxide and the balance of water.
The preparation method of the whitening composition of the embodiment comprises the following steps:
pre-processing:
1. adding o-cymene-5-alcohol into PPG-3 benzyl ether myristate, heating, stirring, and dissolving completely;
2, dissolving sodium hydroxide and water, and completely cooling for later use;
3. adding ascorbyl glucoside into water, stirring and dissolving completely;
(II) manufacturing:
1. glyceryl stearate, PEG-100 stearate, cetearyl alcohol, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, lecithin, lauryl alcohol, myristyl alcohol, cetyl alcohol, steareth-21, steareth-2, cocoyl-caprylate/caprate, CAMELLIA OLEIFERA (Camellia OLEIFERA) seed oil) and acryloyl dimethyl ammonium taurate/VP copolymer are heated to 80 ℃ for complete dissolution, the front-end 1 is put into the reactor, and polydimethylsiloxane is uniformly stirred under heat preservation;
2. adding water into a water kettle, adding EDTA disodium, glycerol and 1, 3-propylene glycol, stirring to dissolve completely, heating to 80 deg.C, and adding into the container 1 via a vacuum funnel for emulsifying for 13 min;
3. homogenizing for 3min with funnel input front 2;
4. cooling to 45 deg.C
5. Adding water, butanediol, and root extract of Boerhavia difussa into funnel; sodium palmitoyl prolinate, Nymphaea ALBA (Nymphaea ALBA) flower extract, dipropylene glycol, 1, 3-propanediol, grape (VITIS VINIFERA) juice extract, alteromonas fermentation product extract, glycerol, hydrogenated lecithin, wild soybean (GLYCINE SOJA) oil, sodium oleate, disodium EDTA, yeast extract, caprylhydroxamic acid, 1, 2-hexanediol, sweet orange (CITRUS AURANTIUM DULCIS) peel oil, CITRUS (CITRUS RETICULATA) peel extract, basil (OCIMUM BASILICUM basilicium) oil, spearmint (MENTHA SPICATA) flower/leaf/stem extract, ROSA DAMASCENA (ROSA daviana) flower oil, grapefruit (CITRUS GRANDIS) peel oil, rose bengal (cymbidium) oil, VANILLA (lilium roseum) flower oil, rose benium (cymbidium) flower oil, rose flower oil (calendula officinalis) flower oil, and white flower oil (calendula oil), white flower oil (calendula officinalis) flower oil, calendula officinalis flower oil (calendula officinalis) flower oil, calendula officinalis flower oil, Oil of herba Salvia OFFICINALIS (Salvia OFFICINALIS), 3 pieces of the above materials, stirring and homogenizing for 3 min;
5. and (3) after the cover is opened and the stirring paddle is scraped completely, homogenizing and stirring are carried out for 1min, the temperature is reduced to 25-30 ℃, stirring is carried out for 10min, and vacuumizing and discharging are carried out, so that the whitening composition is obtained.
Example 2
The whitening composition of the embodiment comprises the following components in percentage by weight:
0.004% of flower extract of SOPHORA JAPONICA (SOPHORA JAPONICA), 0.05% of fermentation product extract of alteromonas, 0.002% of yeast fermentation product extract, 0.01% of ascorbyl glucoside, 5% of CAMELLIA OLEIFERA (CAMELLIA OLEIFERA) seed oil, 0.01% of oil of GLYCINE SOJA, 0.05% of root extract of BOERHAVIA (BOERHAVIA difussa), 0.01% of juice extract of grape (VITIS VINIFERA), 0.1% of flower extract of NYMPHAEA ALBA (NYMPHAEA ALBA), 1% of nicotinamide, 0.00008% of fullerene, 0.4% of squalane, 2.75% of cyclopentadimethylsiloxane, 1.75% of polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, 0.5% of polydimethylsiloxane, 4.3% of glycerol, 0.1% of glycerol polyacrylate, 1%, 6% of 1, 3-propylene glycol, 0.9% of glycerol acrylate/acrylic acid copolymer, 0.15% of propylene glycol, 0.15% of PVM/MA copolymer, 0.5% of sodium acrylate/propylene glycol copolymer, 1.5% of bovine colostrum dimethyl acrylate/dimethyl acrylate copolymer, 0.5% of glycerol, Mineral oil 0.4%, trideceth-60.1%, butylene glycol 2.39%, hydrogenated lecithin 0.01%, sodium oleate 0.01%, disodium EDTA 0.01%, caprylyl hydroxamic acid 0.91%, 1, 2-hexanediol 0.42%, isotridecanol isononate 1%, sodium palmitoyl prolinate 0.32%, dipropylene glycol 0.56%, o-cymene-5-ol 0.09%, peach phenol 0.05%, xanthan gum 0.05%, sweet orange (CITRUS aurantium) peel oil 0.023%, CITRUS (CITRUS RETICULATA) peel extract 0.007%, basil (ocissium) oil 0.0029%, spearmint (MENTHA SPICATA) flower/leaf/stem extract 0.001%, rose damiana (ROSA masna) flower oil 0.001%, grapefruit (CITRUS GRANDIS) peel oil 0.001%, rose phytol (phytolacylvanica) flower oil 0.001%, rose phytol (phytol) flower/stem/leaf/stem extract 0.02%, rose violet (phytol) flower/stem oil 0.001%, rose hibiscus flower oil (phytol) 0.001%, rose hibiscus flower oil (phytol) flower oil 0.001%, rose hibiscus flower oil (phytol) extract 0.02%, rose hibiscus flower oil 0.001%, rose hibiscus flower oil (phytol) 0.001%, rose hibiscus flower oil (phytol) extract 0.001%, rose hibiscus flower, Herba Salvia OFFICINALIS (Salvia OFFICINALIS) oil 0.002%, citric acid 0.01%, and water in balance.
The preparation method of the whitening composition of the embodiment comprises the following steps:
pre-processing:
1. adding xanthan gum into 1, 3-propylene glycol, stirring uniformly, adding water, stirring and dissolving completely;
2, heating, mixing, dissolving and uniformly cooling isotridecanol isononanoate, peach carina phenol and o-cymene-5-alcohol for later use;
3. stirring and mixing 1, 3-propylene glycol, water, glycerol and glycerol polyacrylate uniformly for later use;
4. putting nicotinamide into water, stirring and dissolving completely;
5. adding citric acid into water, stirring and dissolving completely;
6. adding ascorbyl glucoside into water, stirring and dissolving completely;
(II) manufacturing:
1. putting the pre-treatment 1, the pre-treatment 3 and the pre-treatment 4 into a main emulsifying pot, homogenizing and stirring uniformly;
2. adding the pre-treatment 2 into sodium acrylate/sodium acryloyldimethyl taurate copolymer, mineral oil, tridecyl alcohol polyether-6, cyclopentadimethylsiloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer and CAMELLIA OLEIFERA (CAMELLIA OLEIFERA) seed oil, stirring and dispersing uniformly, and adding into the pre-treatment 1 for emulsifying and stirring uniformly;
3. putting the funnel into a pretreatment 5, homogenizing and stirring uniformly;
4. adding water, butanediol, root extract of Boerhavia diffuis (Boerhavia diffuis), sodium palmitoyl prolinate, flos Nymphaeae (Nymphaea ALBA) extract, dipropylene glycol, 1, 3-propylene glycol, grape (VITIS VINIFERA) juice extract, glycerol acrylate/acrylic acid copolymer, propylene glycol, PVM/MA copolymer into the funnel; butanediol, alteromonas ferment product extract, butanediol, glycerol, hydrogenated lecithin, Glycine SOJA (Glycine SOJA) oil, sodium oleate, disodium EDTA, fullerene, squalane, 1, 3-propanediol, yeast extract, octanoyl hydroxamic acid, 1, 2-hexanediol, sweet orange (CITRUS AURANTIUM DULCIS) peel oil, CITRUS (CITRUS RETICULATA) peel extract, basil (OCIMUM BASILICUM) oil, spearmint (MENTHA SPICATA) flower/leaf/stem extract, ROSA DAMASCENA (ROSA DAMASCENA) flower oil, pomelo (CITRUS GRANDIS) peel oil, ROSA rugosa (cymbidium jasminoidi) oil, VANILLA (cymopogon MARTINI) fruit extract, geranium PELARGONIUM (PELARGONIUM GRAVEOLENS) oil, anthrisonia (anthrisonia bilis) flower oil, SALVIA (salvinia OFFICINALIS) oil, pretreatment 6, and homogenizing under stirring.
5. And (3) after the cover is opened and the stirring paddle is scraped completely, homogenizing and stirring are carried out for 5min, and vacuumizing and discharging are carried out, so that the whitening composition is obtained.
Example 3
This example differs from example 1 only in that this example does not contain grape juice extract, yellow-hearted root extract and white water lily flower extract, and the missing ingredients are made up with water, the preparation method being the same as example 1.
Example 4
This example differs from example 2 only in that this example does not contain grape juice extract, yellow-hearted root extract and white water lily flower extract, the missing ingredients are complemented with water, and the preparation method is the same as example 2.
Comparative example 1
This comparative example differs from example 1 only in that it does not contain ascorbyl glucoside, alteromonas fermentation product extract, yeast extract and sophora flower extract, and the missing ingredients are made up with water, the preparation method being the same as example 1.
Comparative example 2
This comparative example differs from example 2 only in that it does not contain ascorbyl glucoside, alteromonas fermentation product extract, yeast extract and sophora flower extract, and the missing ingredients are made up with water, the preparation method being the same as example 2.
Example 5
The test entrusted to the research on the cosmetics application system and the research institute of cosmetics science and technology of Hongyao science and technology university comprises the following specific methods and test results:
the first test method comprises the following steps:
(1) subject criteria and number: 20 healthy women, age range: 20-60 years old. A healthy female is defined as one who does not have chronic disease or major illness or allergic constitution and does not currently take any medications.
(2) Test design and carrying out steps:
(2) before using the product, 1.20 testees firstly carried out arm front side cloth pasting tests and first facial skin tests. All subjects performed a second skin test one week after use of the test product, a third skin test two weeks after use of the test product, a fourth skin test four weeks after use of the test product, a fifth skin test six weeks after use of the test product, and a sixth skin test eight weeks after use of the test product. The skin test comprises measuring skin elasticity coefficient R2, melanin content and water content change. The skin elasticity measuring probe Cutomer, the dark reddish dye probe MX18, and the water content probe CM825 of the German skin measuring instrument MPA580(Courage and Khazaka, Electronic GmbH, Cologne, Germany) were used. The above-mentioned measuring method is non-invasive measuring method (non-invasive measurements), after the probe is contacted with the skin surface, the skin related index can be measured according to the resistance of water, optical principle and physical pulling principle.
(2) The tail of eyes of two eyes of the face is translated for one centimeter, then the position of cheekbone of the two centimeters is moved downwards for positioning, and the position of the two centimeters on the centers of two eyebrows is positioned;
(2) test product use method: the product is used by each testee in the morning and at night every day, and is uniformly smeared on the face.
(2) -4. test environment:
the indoor temperature is 20 +/-1 ℃, the relative humidity is 50 +/-5%, the test is carried out in a closed space, the direct sunlight is avoided, and no air-conditioning air outlet exists in a test site.
(2) Subject restriction with other products to rule out the combined side effects of using the product.
(3) Test period and progress:
the test period is from 107 years 6 months 14 days to 107 years 7 months 14 days, the product period is 4 weeks, and the test frequency is 6 times (1 hand and 5 faces).
(4) The evaluation method comprises the following steps:
the skin-quality improvement rate is (skin-quality index after using the product-skin-quality index before using the product) ÷ skin-quality index before using the product × 100.
The experimental results are as follows:
(1) skin patch test: a proper amount of the whitening cream described in example 1 and the spot-fading pen described in example 2 were dipped on a 3M waterproof patch of 20 subjects, and a patch test was performed on the front side of the arm using a sterile cotton swab, and one of the test results is shown in FIG. 1 with physiological test water as a control group, wherein A is the whitening composition described in example 2, and B is the whitening composition described in example 1, and the test results show that no allergy or irritation reaction occurred in the test results of 20 subjects.
(2) Skin elasticity coefficient:
r2 change test shows that after 20 subjects use the whitening compositions of the embodiment 1 and the embodiment 2 in sequence, the skin elasticity compaction change rate% of the 20 subjects is shown in the table 1, and the results show that the tested products have good high-magnification improvement effect on the skin elasticity compaction change of the subjects.
TABLE 1
Figure BDA0002362578080000101
(3) Skin melanin content change test:
after 20 subjects sequentially use the whitening compositions described in examples 1 and 2, the average value of the change rate% of the skin melanin content is shown in table 2, and the results show that the tested products have the effect of reducing the melanin content at a high rate on the skin melanin content change of the subjects.
TABLE 2
First week rate of change% Second week Rate of Change% Third week Change Rate% The fourth peripheral rate of change%
Left cheek -1.68648 -2.57112 -2.47107 -3.63962
Right cheek -1.37416 -1.75963 -2.40877 -3.56557
Forehead head -1.14508 -1.32887 -1.3399 -2.48588
Mean value of -1.40191 -1.88654 -2.07325 -3.23036
(4) Skin moisture content change test:
after 20 subjects sequentially use the whitening compositions described in examples 1 and 2, the average value of the percent change of the skin moisture content is shown in table 3, and the results show that the tested products have good high-rate improvement effect on the skin moisture content change of the subjects.
TABLE 3
First week rate of change% Second week Rate of Change% Third week Change Rate% The fourth peripheral rate of change%
Left cheek 5.464695 9.560916 12.59608 16.99696
Right cheek 5.166712 9.319603 15.04487 15.48882
Forehead head 3.057975 9.446728 12.90235 15.32084
Mean value of 4.563127 9.442415 13.51443 15.93554
Tables 1-3 show that after 20 women of 20-60 years old use the whitening composition in example 1 and example 2 every morning and evening, the skin efficacy test result of a human body shows that the skin elasticity and compactness of a tested person can reach 11.78 times after the whitening composition is used for 2 weeks; after the use for 4 weeks, the effect of improving the skin elasticity and compactness of the tested person is increased to 61.13 times; the subject apparently experienced poor elasticity and became firm and elastic. The change rate of the melanin content related to the skin whitening is 1.35 times of the melanin content of the skin of a tested person after the skin whitening lotion is used for 2 weeks; after the skin care product is used for 4 weeks, the melanin content of the skin of a tested person is reduced by 2.3 times, the skin care product has excellent anti-dullness whitening efficacy, can accurately block melanin, can fade dull, dull and pigmentation, and can make the skin of the tested person bright, white and glossy. Moisture content of the skin of all subjects increased significantly with respect to moisture content of the facial skin. After 2 weeks of use, the moisture content of the skin of the tested person is increased to 2.07 times; after the skin care product is used for 4 weeks, the moisture content of the skin of a tested person is greatly increased to 3.49 times. The result shows that the whitening composition has excellent effects of moisturizing and smoothing dryness and roughness, can endow the skin with high moist feeling, can synchronously condition the problems of the lack of moisture lines and dryness and darkness caused by poor moisture retention of the skin, and can make the skin feel more bright and elastic by adding water.
Example 6
The whitening compositions described in examples 1 to 4 and comparative examples 1 to 2 were used for testing according to the test method of example 5, and 20 persons were used for each group.
(1) Skin patch test: the results of the 20 subjects of examples 1 to 4 and comparative examples 1 to 2 showed no allergic or irritant reaction.
(2) The skin elasticity coefficient results are shown in table 4.
TABLE 4
Figure BDA0002362578080000121
Figure BDA0002362578080000131
(3) The results of the skin melanin content change test are shown in table 5.
TABLE 5
Figure BDA0002362578080000132
(4) The skin moisture content change test results are shown in table 6.
TABLE 6
Figure BDA0002362578080000141
As can be seen from the results of tables 4 to 6, the whitening compositions of examples 1 to 2 are better in restoring skin elasticity, reducing melanin, and having better moisturizing effect.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1. A whitening composition comprising ascorbyl glucoside, an alteromonas fermentation product extract, a yeast extract and a sophora flower extract.
2. The whitening composition of claim 1, comprising the following components in parts by weight: 0.005-0.02 part of ascorbic acid glucoside, 0.01-0.06 part of alteromonas fermentation product extract, 0.001-0.005 part of yeast extract and 0.002-0.006 part of sophora flower extract.
3. The whitening composition of claim 2, further comprising 0.05 to 0.2 parts of a water lily flower extract, 0.01 to 0.1 parts of a common Bulbophyllum root extract, and 0.001 to 0.02 parts of a grape juice extract.
4. The whitening composition of claim 3, further comprising 3 to 8 parts by weight of camellia oleosa seed oil.
5. The whitening composition of claim 3, further comprising 0.005 to 0.02 parts by weight of an oil of wild soybean.
6. The whitening composition of claim 2, further comprising niacinamide, fullerene, and squalane.
7. The whitening composition of claim 6, further comprising niacinamide 0.5 to 2 parts by weight, fullerene 0.00005 to 0.0001 part by weight, and squalane 0.1 to 1 part by weight.
8. The whitening composition of claim 6 or 7, further comprising the following components in parts by weight: 2.5 to 3 parts of cyclopentadimethylsiloxane, 1.5 to 2 parts of polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, 0.3 to 0.8 part of polydimethylsiloxane, 3 to 8 parts of 1, 3-propylene glycol, 1.5 to 3.5 parts of glycerol, 0.05 to 0.2 part of glycerol polyacrylate, 0.5 to 1.5 parts of glycerol acrylate/acrylic acid copolymer, 0.1 to 0.3 part of propylene glycol, 0.1 to 0.3 part of PVM/MA copolymer and 1 to 3 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, 0.1-1 part of mineral oil, 60.05-1.5 parts of tridecyl alcohol polyether, 0.5-2 parts of butanediol, 0.005-0.02 part of hydrogenated lecithin, 0.005-0.02 part of sodium oleate, 0.005-0.02 part of EDTA disodium, 0.5-2 parts of isotridecanol isononanoate, 0.1-0.6 part of sodium palmitoyl prolinate, 0.3-1 part of dipropylene glycol, 0.01-0.2 part of o-cymene-5-ol and 0.03-0.1 part of xanthan gum.
9. The whitening composition of claim 2, further comprising the following components in parts by weight: 2 to 10 parts of 1, 3-propylene glycol, 2 to 10 parts of PPG-3 benzyl ether myristate, 2 to 10 parts of glycerol, 1 to 5 parts of coconut oil alcohol-caprylate/caprate, 0.5 to 2 parts of butanediol, 0.005 to 0.02 part of hydrogenated lecithin, 0.005 to 0.02 part of sodium oleate, 0.01 to 0.1 part of EDTA disodium, 0.5 to 2 parts of glycerol stearate, 0.3 to 1 part of PEG-100 stearate, 0.5 to 2 parts of cetearyl alcohol and 0.5 to 2 parts of polydimethylsiloxane, 0.1-0.5 part of glycerol stearate, 0.1-0.5 part of behenyl alcohol, 0.05-0.3 part of palmitic acid, 0.05-0.3 part of stearic acid, 0.01-0.1 part of lecithin, 0.01-0.1 part of lauryl alcohol, 0.01-0.1 part of myristyl alcohol, 0.01-0.1 part of cetyl alcohol, 210.5-1 part of steareth-210.5 parts of ammonium acryloyldimethyl taurate/VP copolymer, 20.3-0.8 part of steareth-20.3 parts of palmityl prolinate, 0.1-0.6 part of palmityl prolinate and 0.3-1 part of dipropylene glycol.
10. A cream, aqua or emulsion comprising the whitening composition of any one of claims 1 to 9.
CN202010029276.8A 2020-01-10 2020-01-10 Whitening composition Pending CN111110624A (en)

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CN116236428A (en) * 2023-03-02 2023-06-09 佐登妮丝(广州)美容化妆品有限公司 Whitening and moisturizing composition, emulsion and preparation method thereof
CN116440049A (en) * 2023-05-31 2023-07-18 诺德溯源(广州)生物科技有限公司 Whitening composition suitable for sensitive muscles and having skin barrier repairing effect and application thereof

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CN109431908A (en) * 2018-12-26 2019-03-08 广州市科能化妆品科研有限公司 Skin whitening, moisturizing frost and preparation method thereof and skin-lightening cosmetic additive
CN110302071A (en) * 2019-06-18 2019-10-08 苏州绿叶日用品有限公司 Blue light protection cosmetic composition and preparation method thereof and the cosmetics for including the composition

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CN109276529A (en) * 2018-09-28 2019-01-29 康美时代(广东)发展有限公司 A kind of lightening compositions and the whitening lotion comprising the composition
CN109431908A (en) * 2018-12-26 2019-03-08 广州市科能化妆品科研有限公司 Skin whitening, moisturizing frost and preparation method thereof and skin-lightening cosmetic additive
CN110302071A (en) * 2019-06-18 2019-10-08 苏州绿叶日用品有限公司 Blue light protection cosmetic composition and preparation method thereof and the cosmetics for including the composition

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116236428A (en) * 2023-03-02 2023-06-09 佐登妮丝(广州)美容化妆品有限公司 Whitening and moisturizing composition, emulsion and preparation method thereof
CN116236428B (en) * 2023-03-02 2024-01-23 佐登妮丝(广州)美容化妆品有限公司 Whitening and moisturizing composition, emulsion and preparation method thereof
CN116440049A (en) * 2023-05-31 2023-07-18 诺德溯源(广州)生物科技有限公司 Whitening composition suitable for sensitive muscles and having skin barrier repairing effect and application thereof
CN116440049B (en) * 2023-05-31 2023-12-22 诺德溯源(广州)生物科技有限公司 Whitening composition suitable for sensitive muscles and having skin barrier repairing effect and application thereof

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