CN106491498A - The production method of Camellia nitidissima Chi protective skin cream - Google Patents
The production method of Camellia nitidissima Chi protective skin cream Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of method of effective component extracting from rare species Camellia nitidissima Chi Fresh leaves or fresh flowers and preparing the application of protective skin cream, be efficiently extract with small-micelle water, film engineered molecule retention etc. modern biotechnology prepare JINHUA Flos Camelliae Japonicae and leaf extract, rich in antioxidant content and anti-inflammation compositions such as polyphenol, flavone, extract and separate yield high, can be used to prepare protective skin cream.
Description
Technical field
The present invention relates to a kind of method that effective component extracting from plant makes protective skin cream, particularly from rare species gold
In scented tea Fresh leaves or fresh flowers, effective component extracting makes the production method of Camellia nitidissima Chi protective skin cream.
Background technology
Camellia nitidissima Chi, Classification system（Camellia nitidissima C. W. Chi）；Camellia nitidissima Chi belongs to Theaceae, Flos Camelliae Japonicae
Category, nineteen sixty are found first in China；Camellia nitidissima Chi is a kind of ancient plant, extremely rare, is distributed extremely narrow, the whole world
90% wild Camellia nitidissima Chi is only distributed in blue one band of mountain offshoot of Zhuang National Minority of China autonomous region Fangchenggang City Shiwan Dashan, growth
Below 700 meters of height above sea level, the Nanning in Guangxi, Qinzhou City and Vietnam also find on a small quantity, but quantity is few；Camellia nitidissima Chi blooms for gold
Yellow, dazzling brilliant, coating of wax is seemingly applied, sparkling and crystal-clear and glossy, seemingly there is translucent sense, be precious plant rare in the world
Thing, the external " Dongfang " magic tea for being referred to as mystery, is described as " plant kingdom giant panda ", " tea race queen ".
Show through inspection, the nontoxic level of JINHUA Camellia, containing more than 400 kinds of nutrient substance, have no toxic side effect.Particularly Camellia nitidissima Chi
Rich in tea polysaccharide, tea polyphenols, Total saponin, total flavones, tea pigment, caffeine, protein, vitamin B1, B2, vitamin C, dimension life
Multiple natural nutrition compositions such as plain E, Folic Acid, fatty acid, B- carotene；Also containing tens kinds of amino such as theanine, threonine
Acid, and rich in there is multiple natural organic germaniums to human body with important health-care effect（Ge）, selenium（Se）, molybdenum（M）, zinc（Zn）、
Vanadium（V）Deng trace element, and potassium（K）, calcium（Ca）, magnesium（Mg）Deng macroelement.Among the people is " refreshing tea " also known as Camellia nitidissima Chi；Camellia nitidissima Chi
There is obvious blood sugar lowering and glucose in urine to act on, can effectively improve diabetes " three high " symptom.Camellia nitidissima Chi effectively reduce blood glucose,
While blood pressure, can effective reduction blood fat, improve cause because of hypertension various and be not suitable with symptom, reduce cholesterol in serum
With B- lipoproteins, promote insulin secretion, enhancing immunity, regulating blood flow amount, atherosclerosis are anti-inflammation, clear
Thermal detoxification, relieving constipation diuresis are dried, and promote liver metabolism, anti-cancer and suppress tumour growth etc..Additionally, our research indicate that, JINHUA
Tea has obvious action for the internal aldehyde dehydrogenase of raising, therefore there is with other Camellia nitidissima Chi and improve ethanol dehydrogenase
The material matching of activity, can play quickening ethanol and decompose, alleviate the effect of poisoning symptom after drinking.
Camellia nitidissima Chi while blood glucose, blood pressure is effectively reduced, can effective reduction blood fat, it is each that improvement causes because of hypertension
Plant and be not suitable with symptom, reduce cholesterol in serum and B- lipoproteins, promote insulin secretion, enhancing immunity, regulating blood flow amount,
Atherosclerosis, anti-inflammation, heat-clearing and toxic substances removing, relieving constipation diuresis dry, and promote liver metabolism, anti-cancer and suppress tumour growth
Deng.General flavone content 4400mg/kg in Camellia nitidissima Chi, flavone compound have lowering blood pressure and blood fat, prevent thrombosiss,
Cardiovascular and cerebrovascular disease is prevented and treated, is strengthened immunity, is reduced vascular fragility, improves the effect such as cardiovascular and cerebrovascular vessel blood circulation, can be with antibacterial
And antiviral, antioxidation, defying age, radioprotective, cough-relieving, eliminating the phlegm, and anti-toxin for liver.Selenium is human erythrocyte GSH-PX activity
The composition of enzyme, he have antioxidation, protect cell membrane, protect cardiovascular effect.Chinese Scientists also find that selenium is treatment Keshan
Disease and the active drug of Kaschin-Beck disease, additionally, selenium also has function of detoxification, reduce the toxicity of yellow song B1, to some chemical carcinogens
Matter has Attenuation, moreover it is possible to mitigate toxin to hepatocellular infringement.Germanium can reduce the bioelectric potential of cancerous cell, change its physiology shape
State, the increment growth of anticancer, can also induce the interferon of cancer-resisting substance in human body, macrophage induction can be changed into anti-
Cancerous cell, therefore someone uses germanium treating cancer, in addition germanium is to sclerosis of blood vessels, cerebral thrombosiss, cerebral hemorrhage, kidney hepatopathy, gastropathy, diabetes,
Arthritis, chronic neuralgia also have obvious curative effect.The effect of JINHUA Flos Camelliae Japonicae, can astringing to arrest bleeding, master have blood in stool；Menorrhagia,
Especially advantageous to women.
As follows with regard to the document from Camellia nitidissima Chi effective component extracting：
1st, Chinese patent, a kind of nourishing skin cream application number containing Camellia nitidissima Chi：CN200410092085.7 discloses (bulletin)
Number：CN1633982A applies for (patent right) people：Huang helps people's classification number：A61K7/48 makes a summary：Disclosed by the invention is one
Plant the nourishing skin cream containing Camellia nitidissima Chi.At present, the raw material used by protective skin cream is organic or inorganic chemical substance, and great majority are
The side-product of PETROLEUM PROCESSING, therefore, skin care effect is limited.The present invention add in the raw material of conventional protective skin cream Camellia nitidissima Chi,
Margarita powder and vitamin E, under the collaboration of these raw materials so that the present invention has heat-clearing and toxic substances removing, supplements the nutrients, bacteriostatic skin-care,
And the effect of defying age.
2nd, Chinese patent, a kind of JINHUA tea extract, application number：The CN03140885.0 applyings date：2003.06.05 it is public
The number of opening：CN1476767A applicant：Guangxi Fuxin Science ＆ Technology Co., Ltd. makes a summary：Disclosed by the invention is a kind of JINHUA
Tea extract.Contain many compositions beneficial to human body in Camellia nitidissima Chi, but be not fully used for a long time, existing carry
The method of depletion scented tea composition is high temperature extraction and concentration, so can partly destroy its effective ingredient, the present invention using alcohol extraction and
Water extraction combines, and adopts ultrasonic wave concussion, and to improve extraction efficiency, overall process employs the cryogenic conditions less than 60 DEG C, has
Effect protects the aromatic substance in Camellia nitidissima Chi and the various compositions with health care, and extraction rate reached, and can to more than 90%
Shorten extraction time, reduce cost.
3rd, Chinese patent, the method for extracting camellia chrysantha polysaccharide from leaf of Camellia nitidissima Chi, application number： CN201510707853.3
The applying date：2015.10.27 publication number：CN105175569A, applicant：Medical Colleges Of Guilin makes a summary：The invention provides
The method for extracting camellia chrysantha polysaccharide from leaf of Camellia nitidissima Chi, comprises the following steps：1) by leaf of Camellia nitidissima Chi extracting in water, water extraction is obtained
Liquid；2) after concentrate Aqueous extracts, ethanol precipitation is added, taking precipitate is standby；3) by step 2) precipitate use anhydrous second successively
Alcohol, washing with acetone, then plus distill water dissolution, add protease hydrolyzed, obtain enzymolysis solution；4) enzymolysis solution is placed in frequency is
10～60s is processed under 1000～5000kHz ultrasound wave, then through the bag filter dialysis that molecular cut off is 10000, is gone bail for and is stayed liquid
Through the bag filter dialysis that molecular cut off is 500000, permeate concentration is taken, ethanol precipitation is added, taking precipitate is standby；5)
By step 4) described in precipitate successively use dehydrated alcohol, washing with acetone, then plus distillation water dissolution, activated carbon decolorizing, filter,
Dry, as camellia chrysantha polysaccharide.The camellia chrysantha polysaccharide that the present invention is obtained has preferable immunocompetence.
4th, Chinese patent, a kind of camellia nitidissima concentrate, application number：CN03149225.8, the applying date：2003.06.18, public
The number of opening：CN1460438A, applicant：Guangxi Fuxin Science ＆ Technology Co., Ltd., summary：The invention discloses a kind of JINHUA
Tea concentrated solution.Conventional high temperature extraction method for concentration is employed to the concentration of JINHUA tea extract at present, at high operating temperatures,
Easily make the aromatic substance in Camellia nitidissima Chi volatilize to scatter and disappear, or even active component is subject to compared with havoc.The present invention is used
Nanometer membrance separation concentration technique can be concentrated to JINHUA tea extract under the conditions of 25-40 DEG C, it is to avoid heating is concentrated
Destruction of the journey to active ingredient, and the loss of active ingredient.The present invention is to carry out the basis of Camellia nitidissima Chi series product development, can be with
Camellia nitidissima Chi food, beverage, health product, article of everyday use and medicine are further developed.
5th, Chinese patent, a kind of Camellia nitidissima Chi flavonoid glycoside and its production and use, application number： CN201210045032.4
The applying date：2012.02.24 publication number：CN102617672A, applicant：University Of Dalian makes a summary：The present invention relates to one kind from
Detached anticancer compound Camellia nitidissima Chi flavone glycosides A and its production and use in JINHUA Flos Camelliae Japonicae.The present invention is from JINHUA Flos Camelliae Japonicae
In the acetic acid ethyl ester extract of 95% ethanol extraction, isolated monomeric compound and fraction show through qualitative, quantitative determination
Predominantly flavones ingredient, and the chemical constitution of the compound is determined through the analysis of modern spectral technique, chemistry is entitled：Cortex querci dentatae
Element -7-O- (6 "-O-E- coffee acyls)-β-D-Glucose glycosides.Show through anticancer experiment in vitro, the compound substantially can suppress
Tumor cell proliferation, and the activity with inducing apoptosis of tumour cell.The invention product possesses the potentiality to be exploited of antitumor drug.
6th, Chinese patent, a kind of CO2 supercritical methanol technologies extract the process application number of Camellia nitidissima Chi leaf flavonoids：
The CN201410000082.X applyings date：2014.01.02 publication number：CN103705647A, applicant：Qingdao Agricultural University
Summary：The invention discloses a kind of CO2 supercritical methanol technologies extract the process of Camellia nitidissima Chi leaf flavonoids, which comprises the following steps：
1) Camellia nitidissima Chi is crushed to 20～100 mesh, is placed in extractor；2) with 55～85% ethanol as carrying agent, supercritical CO 2 is molten
Agent；3）35～55 DEG C of extractor temperature, 25～35MPa of pressure, CO2 10～20L/h of flow；25 DEG C of flash trapping stage tank temperature, pressure
6～8MPa of power；25 DEG C of the second-order separation tank temperature, pressure 6MPa；2～4h of extraction time；The ethanol of leaf of Camellia nitidissima Chi total flavones can be obtained
Solution；4) ethanol is reclaimed in vacuum distillation, and lyophilization obtains final product auburn leaf of Camellia nitidissima Chi total flavonoids extract.Extracted using the method
Total flavones, organic solvent-free is remained, simple and easy to do, and high income, and yield can be widely applied to food, medicine up to 3.81%
In field, the economic benefit and social benefit of Camellia nitidissima Chi can be obviously improved.
7th, Chinese patent, JINHUA Flos Camelliae Japonicae extract and its preparation method and application, application number： CN201510267354.7
The applying date：2015.05.22 publication number：CN104958440A, 2015.10.07 applicant：Dalian University of Technology makes a summary：
The invention discloses JINHUA Flos Camelliae Japonicae extract, preparation method is to mix JINHUA Flos Camelliae Japonicae with conch meal, micro-cutting change-auxiliary agent interaction skill
Art mechanical activation comminution, is extracted using water or ethanol, and the Extracting temperature is 80～100 DEG C；JINHUA Flos Camelliae Japonicae extract contains 20-
The total saponins of the total flavones of 40wt%, the saccharide of 20-40wt%, the tea polyphenols of 1-10wt% and 1-10wt%；The present invention is also carried
The application in treatment or prevention non-alcoholic fatty liver disease medicine is being prepared for JINHUA Flos Camelliae Japonicae extract.JINHUA Flos Camelliae Japonicae extract of the present invention
The fatty liver level of non-alcoholic fatty liver disease can be mitigated, to blood and liver in TG, TC decrease, and toxic and side effects
Little；There is preferable preventive and therapeutic effect to alcoholic fatty liver.
8th, Chinese patent, the method for extracting polyphenols from leaf of Camellia nitidissima Chi, application number：CN201510573856.2
The applying date：2015.09.10 publication number： CN105168593A ；Applicant：Medical Colleges Of Guilin makes a summary：The invention provides
The method for extracting polyphenols from leaf of Camellia nitidissima Chi, including：1) leaf of Camellia nitidissima Chi ethanol is extracted, filters, take filtrate standby；2)
Filtrate is crossed the hollow-fibre membrane that molecular cut off is 5000, first time concentrated solution and first time permeate is obtained；Will be for the first time
Concentrated solution crosses the hollow-fibre membrane that molecular cut off is 20,000, obtains second permeate and second concentrated solution, and will be for the second time
It is 100,000 that concentrated solution crosses molecular cut off, obtains third time permeate；3) by low pole macroporous absorption tree on first time permeate
Fat post, first washing post is to colourless, then uses ethanol elution, collection ethanol elution；4) will be nonpolar macroporous on third time permeate
Adsorption resin column, first washing post is to colourless, then ethanol elution, collects ethanol elution；5) by step 3) and step 4) eluting
Liquid mixes, concentration, dries, obtains final product polyphenols.The polyphenol substance that the present invention is extracted has extremely strong anti-liver cancer efficacy.
9th, Chinese patent, leaf of Camellia nitidissima Chi active site, Its Preparation Method And Use application number： CN201310070480.4
The applying date：2013.03.06 publication number：CN104027477A, applicant：Guangxi Medical University makes a summary：Disclose Camellia nitidissima Chi
Leaf active site, Its Preparation Method And Use.Preparation method includes：A. infiltrate：Depletion scented tea leaf coarse powder, with 5 times (V/W)
The alcoholic solution soaked overnight of 30% or more concentration；B. extract：In with the alcoholic solution of same concentrations in step A to step A
Leaf of Camellia nitidissima Chi coarse powder heating and refluxing extraction 2 times or more than 2 times, 10～40 times (V/Ws) of the alcoholic solution consumption for leaf of Camellia nitidissima Chi coarse powder,
Extraction time is 1～4 hour every time, filters, and united extraction liquid, concentrating under reduced pressure, recycling design obtain crude extract, filters, takes filter
Liquid, obtains medicinal liquid proportion for 1.05～1.25；C. macroporous adsorbent resin is processed：The filtrate in step B is taken, through macroporous resin column chromatography
Separate, successively with the 10% of 10 times of column volumes, 30%, 80%, 95% ethanol water elution, collect each elution fraction respectively, will
80% ethanol water elution fraction vacuum distillation；The macroporous resin selected from AB-8, D101, D201, D140, D141A, D301,
D401, HP20 and HPD-100；D. dry：The 80% ethanolic moiety lyophilization that step C is obtained, obtains final product.
10th, Chinese patent, Camellia nitidissima Chi leaf extract and application thereof, application number：CN201410604971.7, publication number：
CN104274611A applicant：Fangchenggang Wanjing Forestry Co., Ltd. makes a summary：A kind of Camellia nitidissima Chi leaf extract and its use
On the way.Leaves of plants of the extract from Camellia nitidissima Chi, the mass percent of its significant component tea polyphenols is 3.5%～20%,
Its preparation method is will to filter after the leaves of plants extracting in water of Camellia nitidissima Chi, and filtering residue is also filtered after the extracting in water of 1～5 time, is closed
And gained filtrate, drying under reduced pressure, obtain product；The process of leaves of plants and filtering residue extracting in water is：Add 5～30 times of weight
Water, ceases fire after being heated to boiling, and 10～180min of hot dipping ceases fire after being again heated to boiling, 1～180min of hot dipping.The extraction
Thing is mainly the Polyphenols extract of leaf of Camellia nitidissima Chi, and preparation method is simple, suitable industrialized production；And the leaf of Camellia nitidissima Chi is more
The hypoglycemic activity of phenols extract significantly, can be used to prepare hypoglycemic medicine, food, health product, or it is resistance to prepare treatment sugar
Amount exception, insulin resistant, metabolic syndrome, the medicine of relevant disease caused by essential hyperglycemia, applied widely.
11st, Chinese patent, a kind of preparation method of leaf of Camellia nitidissima Chi pigment, application number：CN201410541226.2, application
Day：2014.10.14 publication number：CN104306559A, applicant：Wang Huiying makes a summary：The present invention discloses a kind of Camellia nitidissima Chi
The preparation method of chromophyll, step are as follows：1) dried leaves of Camellia nitidissima Chi are crushed to 40～120 mesh, are soaked 1～5 hour with hydro-thermal
Afterwards, after common filter-cloth filtering, filtrate pore size filter is 0.1～0.5 μm of microfiltration membrane microfiltration, and gained filtrate is crude extract；
2) crude extract is crossed macroporous adsorbent resin chromatographic column, with 50%～80% alcoholic solution elution chromatography post, collects eluent, wash
De- liquid is evaporated to the 30%～40% of original volume, and concentrated solution is placed in reactor, and reactor blowing air is aoxidized, after oxidation
Concentrated solution in add the modified starch of its weight 0.5%～1.5%, leaf of Camellia nitidissima Chi pigment is obtained after spray drying.The present invention
Tea pigment can fully be extracted and catechin is converted into tea pigment, so as to the high extract of prepared dark brown cellulose content, the method letter
Single easily-controllable, it is easy to promote, new way can be gone out for the exploitation of leaf of Camellia nitidissima Chi.
12nd, Chinese patent, the extracting method of camellia chrysantha polysaccharide, application number：The CN201510705138.6 applyings date：
2015.10.27 publication number：CN105153324A, applicant：Medical Colleges Of Guilin, summary：The invention provides a kind of JINHUA
The extracting method of tea polysaccharide, comprises the following steps：1) by leaf of Camellia nitidissima Chi extracting in water, Aqueous extracts are obtained；2) Aqueous extracts are concentrated
Afterwards, ethanol precipitation is added, and taking precipitate is standby；3) by step 2) precipitate successively use dehydrated alcohol, washing with acetone, Ran Houjia
Distillation water dissolution, adds protease hydrolyzed, obtains enzymolysis solution；4) enzymolysis solution is placed under frequency ultrasonic wave and is processed, Ran Houjing
Molecular cut off be 18000～28000 bag filter dialysis, go bail for stay liquid through molecular cut off be 400000～500000 saturating
Analysis bag dialysis, takes permeate concentration, adds ethanol precipitation, and taking precipitate is standby；5) by step 4) described in precipitate successively
With dehydrated alcohol, washing with acetone, then plus water dissolution is distilled, activated carbon decolorizing is filtered, dried, as camellia chrysantha polysaccharide.This
The bright camellia chrysantha polysaccharide for obtaining has preferable immunocompetence.
13rd, Chinese patent, leaf of Camellia nitidissima Chi active site, Its Preparation Method And Use, application number： CN201310070499.9
The applying date：2013.03.06 publication number：CN104027478A, applicant：Guangxi Medical University makes a summary：Disclose leaf of Camellia nitidissima Chi
Active site, Its Preparation Method And Use.Preparation method includes：A. infiltrate：Depletion scented tea leaf coarse powder, with 5 times of (V/W) 30%
Or more concentration alcoholic solution soaked overnight；B. extract：With with the alcoholic solution of same concentrations in step A to step A in JINHUA
Coarse tea leaf powder heating and refluxing extraction 2 times or more than 2 times, 10～40 times (V/Ws) of the alcoholic solution consumption for leaf of Camellia nitidissima Chi coarse powder, every time
Extraction time is 1～4 hour, filters, and united extraction liquid, recycling design obtain condensed cream；C. extract：By the condensed cream water
It is suspended, successively with petroleum ether, ethyl acetate, n-butanol extraction, takes the extract after ethyl acetate extraction, recycling design；D. do
Dry：The acetic acid ethyl ester extract lyophilization that step C is obtained, obtains final product.
14th, Chinese patent, the method for extracting polyphenol from leaf of Camellia nitidissima Chi, application number：CN201510573558.3 applies
Day：2015.09.10 publication number：CN105055669A, applicant：Medical Colleges Of Guilin makes a summary：The invention provides from gold
The method for extracting polyphenol in scented tea leaf, including：1) by leaf of Camellia nitidissima Chi alcohol reflux, filter, take filtrate standby；2) by filtrate
The hollow-fibre membrane that molecular cut off is 3000 is crossed, first time concentrated solution and first time permeate is obtained；By first time concentrated solution
The hollow-fibre membrane that molecular cut off is 10,000 is crossed, second permeate and second concentrated solution is obtained, and by second concentrated solution
It is 80,000 to cross molecular cut off, obtains third time permeate；3) by low pole macroporous adsorptive resins on first time permeate, first
Washing post is to colourless, then uses ethanol elution, collection ethanol elution；4) by nonpolar macroporous adsorption resin on third time permeate
Post, first washing post is to colourless, then ethanol elution, collects ethanol elution；5) by step 3) and step 4) eluent mixing, dense
Contracting, dries, obtains final product polyphenols.The polyphenol that the present invention is extracted has extremely strong anti-liver cancer efficacy.
Document disclosed above is discussed to extracting Camellia nitidissima Chi effective ingredient from different perspectives, has water extraction, alcohol extracting method, acetic acid
Ethyl ester extraction, carbon dioxide supercritical fluid extraction method, membrane separation concentration method, Middle hollow fiber membrane method and enzymatic isolation method etc., obtain
The Camellia nitidissima Chi effective ingredient of different purposes, but there is an extraction method to be only limited to obtain fractions, and most useful component exists
It is lost in operating process or wastes, valuable resource fails to make full use of.
Content of the invention
It is an object of the invention to provide one kind is from effective component extracting in rare species Camellia nitidissima Chi Fresh leaves or fresh flowers,
Then make protective skin cream, be efficiently extract with small-micelle water, film engineered molecule retention etc. modern biotechnology prepare
Fresh JINHUA Flos Camelliae Japonicae and leaf extract, rich in the antioxidant contents such as polyphenol, flavone and anti-inflammation composition, extract and separate
Rate is high, can be used to prepare protective skin cream.
The technical scheme is that and be achieved in that：
Camellia nitidissima Chi protective skin cream, it is characterised in that including the raw material of following weight content：
Camellia nitidissima Chi leaf or flower dry cream 1-10%；
Milk 8-15%；
Stearic acid 5-12%；
Glycerol monostearate 3-8%；,
Methyl hydroxybenzoate 0.2-0.8%；
Paraffin 1-3%；
Fructus Citri Limoniae juice 0.5-1.6%；
Mel 0.2-0.8%；
Spice 0.2-1%；
Distilled water adds to 100%.
The process of Camellia nitidissima Chi leaf or flower dry cream is as follows：
1）It is standby that alkaline small group water is obtained first；Described alkaline small group pH 9-13；
2）Fresh Camellia nitidissima Chi leaf and fresh flower is gathered, impurity removing is removed, is dried respectively, standby；
3）Fresh Camellia nitidissima Chi leaf and fresh flower are smashed with pulverizer respectively,
4）It is put in the Camellia nitidissima Chi leaf or flower that smashes respectively using the alkaline small group water of pH 9-13, per kilogram JINHUA
Folium Camelliae sinensis or flower add 8-10 to rise alkaline small group water；, at 1-10 DEG C, time 3-5 hour, then in 10-20 for soaking temperature
DEG C temperature for the first time extract 3-5 hours, isolate extracting solution and slag；The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited；
5）It is put in slag respectively using the alkaline small group water of pH 9-13；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
5-8 rises alkaline small group water；In 10-20 DEG C of temperature control second extraction 2-3 hour, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
6）It is put in slag respectively using the alkaline small group water of pH 9-13；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
3-5 rises alkaline small group water；1-2 hours are extracted in 10-20 DEG C of temperature third time, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
7）By alkaline extracting solution respectively cross ultrafilter membrane, ultrafiltration membrane aperture between 0.05um to 1nm, usual molecular cut off scope
1000～300000, then the ethanol elution with volumetric concentration 70-90%；Obtain the eluent of Camellia nitidissima Chi leaf or flower；Through
Ethanol and concentration is reclaimed, Camellia nitidissima Chi leaf or flower dry cream is obtained；
The manufacture method of Camellia nitidissima Chi protective skin cream is：Respectively by above-mentioned raw materials：Camellia nitidissima Chi leaf or flower dry cream, milk, stearic acid,
Glycerol monostearate, methyl hydroxybenzoate, paraffin, Fructus Citri Limoniae juice, Mel, spice, distilled water add to 100 mass %, and preparation method is：
Above-mentioned raw materials are heated to 95 DEG C of dissolvings respectively, and stirring forms emulsification system, continues stirring formation under cooling conditions rapidly
Paste product, until room temperature.Effect：Speckle dispelling, moisten, delicate, that is, do and take effect；Mechanism：Camellia nitidissima Chi activity is big, containing human body institute
The abundant nutrition composition for needing, is readily absorbed by.
The preparation of the alkaline small group water of described pH 9-13 is that pure water is put in electrolysis bath, just extremely graphite, bears
Extremely platinum；
In electrolysis, the chemical equation of the two poles of the earth generation is：
Negative electrode：2H2O+2e=2OH-+H2
Anode：2H2O-4e=4H++O2.
Described pure water is that carrying out the above filter element filtering in three roads to tap water is carried out at purification with municipal tap water as water source
Reason obtains pure water, or the distilled water obtained after distillation is processed.
Described electrolytic process operating temperature is 50-80 DEG C, and operating current is 0.6-2.0 A/cm2.
Although in above-mentioned background technology, document 1 reports a kind of nourishing skin cream containing Camellia nitidissima Chi, in conventional skin protection
Camellia nitidissima Chi, Margarita powder and vitamin E are added in the raw material of frost, but preparation method is not very clear, effect is not also given.
Document 16, Chinese Patent Application No.：CN201210271906.8 reports Chinese medicine composition wherein has Camellia nitidissima Chi little
Micel natural mineral matter water extract, but do not refer to Camellia nitidissima Chi subset natural mineral matter water extract is how to prepare
Obtain, also do not refer to source and the physical property of subset natural mineral matter water.Semen Vitis viniferae subset day is mentioned in text
So mineral water extract, Radix Glycyrrhizae subset natural mineral matter water extract, Chinese-Angelica micromolecular roll into a ball natural mineral matter water extraction
Thing, Pseudobulbus Bletillae (Rhizoma Bletillae) subset natural mineral matter water extract and Ganoderma subset natural mineral matter water extract also have no which extracts
Method, the public do not know how subset natural mineral matter water obtains yet.
The present invention using subset abundance, be not limited to natural mineral water, can with municipal tap water as water source,
Carrying out the above filter element filtering in three roads, absorption etc. to tap water carries out purification process, or after distillation is processed, then through electrolyzer electric
Solution is obtained.
During electrolytic tank electrolysis, due to the effect of hydrogen bond, tap water is typically made up of 13-15 subset,
When water enters electrolysis bath, in the presence of electric field, the hydrogen bond of hydrone is opened, and generates by the molecular small molecule of 5-6 moisture
Group's water.Meanwhile, the partial cation Ca in the presence of electric field, in solution2+、Mg2+、K+、H+Deng to movable cathode, electric according to obtaining
There is reduction reaction in the power of sub- ability, H ions, obtain electronics and become hydrogen, and as H ion concentrations reduce, hydroxide ion is dense
Degree is then raised, and water body is in alkalescence, and more than 7, the water that this pole generates is referred to as alkaline water to pH value.Simultaneously in anode, anionic part
Cl-、SO42-、NO3-、NO2-、OH-Move Deng Ghandler motion on the sunny side, in numerous aniones, the most volatile de-electromation of hydroxide ion then occurs
Oxidation reaction, loses electronics and produces oxygen and water.As hydroxide ion concentration reduces, H ion concentrations are then raised, and water body is in weak
Acidity, pH value are less than 7, and the water that this pole generates is referred to as acid subset ionized water, and in opposite side, water is obtained after electrolyzed water machine
To the alkalescence small-micelle water that drinks；
Subset be 5,6 hydrones together, activity is high, it is easy to enter cell.It is easy to Absorption And Metabolism, dissolving power, infiltration
Power is strong, it may be said that be life running water.General water is all macromolecular mass, and usual 15 or so molecules together, are difficult by hydrogen bond
Enter cell.And subset is 5, together, activity is high, it is easy to enter cell for 6 hydrones.World Health Organization (WHO) is to health
Point out in the judgment criteria of water：Half fabric width of water clusters is less than 100 hertz, as vigorous small-micelle water.After testing,
The a width of 74.07-79.48 hertz of degree water clusters half range,
The present invention is also small molecule group water using the small-micelle water of alkalescence,（microcluster water, small
cluster water, micro clustered water）, extract in plant Camellia nitidissima Chi Fresh leaves or fresh flowers effectively into
Point, it is a kind of extraordinary raw material, makes various health foods, its meaning is：People is aging year by year until the sick process that dies, is right
Cell insufficient water, gradually acidification, cell lack nutrition to cause Cell sap（It is not that human body lacks nutrition）, and what decline was died young
Process.It is not sick that the mankind want good health and a long life, dies without known cause, if try to allow volume more than pH7.35 alkalescent water freedom
Come in and go out cell, it is possible to accomplishes, problem is just so simple.
Through research, macromolecular mass water is not easily accessed cell, makes intracellular water fewer and feweri, increasingly acid.Little point
Son group water can easily pass through 2 nanometers of hydrophilic channel and enter cell, bring nutrition into, take sour poison out of, to taking good care of one's health, delay to decline
Always, the effect that prevents and cures diseases is self-evident.
The water of subset has any benefit；Because the micel of water is less, the energy of water is bigger, the infiltration of water
Power, dissolving power, metabolism power are stronger.Because its micel little, it is easier to pass in and out cell membrane, transport nutriment, take rubbish out of, become most
Good transport agent, therefore says that the water of subset is the water for being best suitable for human body cell.
The expert of World Health Organization (WHO) find through many investigations, finally the long-lived secret of Changshou village residents ' health with
Local water is relevant.The several conditions for being best suitable for human body drinking water have been made according to the characteristics of the water quality of Changshou village.That is weak base, little
Micel, hexangle type, nagative potential, oxygen carrying are strong, be rich in the six big physiologically actives such as trace element.Micromolecular water has than solid carbon dioxide fruit and vegerable
The high nagative potential of dish（-86~105mV）, the homergy therefore to body is highly beneficial, can remove free radical excessive in vivo,
Improve body immunity.
Alkalescence small-micelle water, can neutralize internal noxious acidic metabolite, drain harmful substance, make body fluid be in weak base
Property, reach prevention and health-care effect.Micromolecular water has the nagative potential higher than solid carbon dioxide fruit vegetable（-86~105mV）, therefore to machine
The homergy of body is highly beneficial, can remove free radical excessive in vivo, improves body immunity.
The substantive distinguishing features of the present invention and significant progress are：
1st, protective skin cream main component of the present invention is from Camellia nitidissima Chi leaf or to spend middle effective component extracting, using the alkalescence of pH 9-13
Small-micelle water is put in the Camellia nitidissima Chi leaf or flower that smashes respectively；Temperature is soaked in low temperature and is extracted, by alkaline extracting solution
Cross ultrafilter membrane respectively, ultrafiltration membrane aperture between 0.05um to 1nm, usual molecular cut off scope 1000～300000, then
Ethanol elution with volumetric concentration 70-90%；The alkaline small group extracting solution of purification is obtained, Camellia nitidissima Chi leaf or flower is obtained
Extract, the protective skin cream speckle dispelling that makes, moisten, delicate, that is, do and take effect；Mechanism：Camellia nitidissima Chi activity is big, containing needed by human body
Abundant nutrition composition, is readily absorbed by.
Due to hydrone H2The effect of hydrogen bond between O, the light water in daily life are by 13-15 hydrone H2O composition compared with
Macromolecular mass water, due to this 13-15 hydrone H2The special construction of O, hydrone H2The zwitterion quilt that the faint ionization of O is produced
Cover mutually, water is in neutrality（PH7.0 or so）.When water enters electrolysis bath, in the presence of electric field, the hydrogen bond of hydrone is beaten
Open, cation Ca in solution2+、Mg2+、K+、H+Deng to movable cathode, according to the power for obtaining electronic capability, H ions are reduced
Reaction, obtains electronics and becomes hydrogen, and as H ion concentrations reduce, hydroxide ion concentration is then raised, and water is gradually partially in alkalescence, PH
Value is more than 7, and this pole generates and is referred to as alkaline small by the molecular water of 5-6 moisture and rolls into a ball water；Simultaneously in anode, anionic part
Cl-、SO42-、NO3-、NO2-、OH-Move Deng Ghandler motion on the sunny side, in numerous aniones, the most volatile de-electromation of hydroxide ion then occurs
Oxidation reaction, loses electronics and produces oxygen and water, and as hydroxide ion concentration reduces, H ion concentrations are then raised, and water is gradually inclined
In acidity, pH value is less than 7, and this pole generates and is referred to as acidity small-micelle water by the molecular water of 5-6 moisture.
2nd, we were tied to obtain the function required for us when JINHUA Flos Camelliae Japonicae and leaf natural product extraction is carried out in the past
Structure component, generally requires to destroy the original organizational structure of animals and plants, and hydrolysis is exactly the extracting method that we generally adopt.Initially
People improve the means of extract polarity improving the hydrolysis efficiency of natural product by adding strong acid, highly basic, so as to obtain compared with
High extraction yield, but the addition of strong acid and strong base makes troubles to production technology and endangers, and also easily introduces to product potential
Hazard factor.Therefore, essence belongs to pure water, just becomes preferable natural product extraction but also with highly polar small-micelle water
Liquid.So the present invention with routine soda acid extracting method compared with, with extraction process gentle, safe and healthy the characteristics of.
3rd, the alkaline JINHUA Flos Camelliae Japonicae for obtaining and leaf extract, rich in antioxidant contents such as polyphenol, flavone, with anti-inflammation
Etc. function.
4th, the present invention processes Camellia nitidissima Chi fresh leaf and fresh flowers with low temperature process, carries using small-micelle water as extract
Taking technique and equipment are uncomplicated, make full use of the effective ingredient of complete JINHUA Flos Camelliae Japonicae and leaf.Obtain high extraction efficiency.Its
Extractum rate can bring up to more than 22% from common acids alkaline extraction method from less than 15%.
5th, the alkaline JINHUA Flos Camelliae Japonicae for obtaining and leaf extract, rich in polyphenol and anti-inflammation composition, making protective skin cream can be high
Effect removes the free radical piled up by skin cell metabolism, improves human detoxification and defensive enginery, makes the vigor of senile cell
Recovered, accelerate to remove dead Skin Cell, promote the new life of Skin Cell, delaying skin aging.So that because year
Age increases caused face macula lutea and shoals and then disappear, and pore shrinks, diminishes or even disappears, and facial thickness wrinkle improves.For a long time
Using skin can be made delicate, smooth, elastic return, it is rich in youth gloss.
Specific embodiment
Embodiment 1,
Camellia nitidissima Chi prescription for skin cream：Parts by weight
Camellia nitidissima Chi leaf or flower dry cream 3%；
Milk 10%；
Stearic acid 10%；
Glycerol monostearate 5%；,
Methyl hydroxybenzoate 0.5%；
Paraffin 2%；
Fructus Citri Limoniae juice 1.0%；
Mel 0.5%；
Spice 0.2%；
Distilled water adds to 100%.
Preparation process is as follows：
The process of Camellia nitidissima Chi leaf or flower dry cream is as follows：
1）It is standby that alkaline small group water is obtained first；Described alkaline small group pH 9-10；
2）Fresh Camellia nitidissima Chi leaf and fresh flower is gathered, impurity removing is removed, is dried respectively, standby；
3）Fresh Camellia nitidissima Chi leaf and fresh flower are smashed with pulverizer respectively,
4）It is put in the Camellia nitidissima Chi leaf or flower that smashes respectively using the alkaline small group water of pH 9-10, per kilogram JINHUA
Folium Camelliae sinensis or flower add 8-10 to rise alkaline small group water；, at 1-10 DEG C, time 3-5 hour, then in 10-20 for soaking temperature
DEG C temperature for the first time extract 3-5 hours, isolate extracting solution and slag；The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited；
5）It is put in slag respectively using the alkaline small group water of pH 9-10；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
5-8 rises alkaline small group water；In 10-20 DEG C of temperature control second extraction 2-3 hour, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
6）It is put in slag respectively using the alkaline small group water of pH 9-10；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
3-5 rises alkaline small group water；1-2 hours are extracted in 10-20 DEG C of temperature third time, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
7）By alkaline extracting solution respectively cross ultrafilter membrane, ultrafiltration membrane aperture between 0.05um to 1nm, usual molecular cut off scope
1000～300000, then the ethanol elution with volumetric concentration 70-90%；Obtain the eluent of Camellia nitidissima Chi leaf or flower；Through
Ethanol and concentration is reclaimed, Camellia nitidissima Chi leaf or flower dry cream is obtained；
The manufacture method of Camellia nitidissima Chi protective skin cream is：Respectively by above-mentioned raw materials：Camellia nitidissima Chi leaf or flower dry cream, milk, stearic acid,
Glycerol monostearate, methyl hydroxybenzoate, paraffin, Fructus Citri Limoniae juice, Mel, spice, distilled water add to 100 mass %, and preparation method is：
Above-mentioned raw materials are heated to 95 DEG C of dissolvings respectively, and stirring forms emulsification system, continues stirring formation under cooling conditions rapidly
Paste product, until room temperature.
The preparation of the alkaline small group water of described pH 9-10 is that pure water is put in electrolysis bath, just extremely graphite, bears
Extremely platinum；
Described pure water is with natural mineral water or municipal tap water as water source, carries out the above filter element filtering in three roads to tap water and enters
Row purification process obtains pure water, or the distilled water obtained after distillation is processed.Described electrolytic process operating temperature is 50-80
DEG C, operating current is 0.6-1.5 A/cm2.
Embodiment 2,
Camellia nitidissima Chi prescription for skin cream：
Camellia nitidissima Chi leaf or flower dry cream 5%；
Milk 11%；
Stearic acid 8%；
Glycerol monostearate 6%；,
Methyl hydroxybenzoate 0.4%；
Paraffin 1%；
Fructus Citri Limoniae juice 1.1%；
Mel 0.4%；
Spice 0.3%；
Distilled water adds to 100%.
Preparation process is as follows：
The process of Camellia nitidissima Chi leaf or flower dry cream is as follows：
1）It is standby that alkaline small group water is obtained first；Described alkaline small group pH 9.5-11；
2）Fresh Camellia nitidissima Chi leaf and fresh flower is gathered, impurity removing is removed, is dried respectively, standby；
3）Fresh Camellia nitidissima Chi leaf and fresh flower are smashed with pulverizer respectively,
4）It is put in the Camellia nitidissima Chi leaf or flower that smashes respectively using the alkaline small group water of pH 9.5-11, per kilogram gold
Scented tea leaf or flower add 8-10 to rise alkaline small group water；, at 1-10 DEG C, time 3-5 hour, then in 10- for soaking temperature
20 DEG C of temperature extracts 3-5 hours for the first time, isolates extracting solution and slag；The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited
Put；
5）It is put in slag respectively using the alkaline small group water of pH 9.5-11；Per kilogram Camellia nitidissima Chi leaf slag or flower slag add
Enter 5-8 and rise alkaline small group water；In 10-20 DEG C of temperature control second extraction 2-3 hour, alkaline extracting solution and slag is isolated；
The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited；
6）It is put in slag respectively using the alkaline small group water of pH 9.5-11；Per kilogram Camellia nitidissima Chi leaf slag or flower slag add
Enter 3-5 and rise alkaline small group water；1-2 hours are extracted in 10-20 DEG C of temperature third time, alkaline extracting solution and slag is isolated；
The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited；
7）By alkaline extracting solution respectively cross ultrafilter membrane, ultrafiltration membrane aperture between 0.05um to 1nm, usual molecular cut off scope
1000～300000, then the ethanol elution with volumetric concentration 70-90%；Obtain the eluent of Camellia nitidissima Chi leaf or flower；Through
Ethanol and concentration is reclaimed, Camellia nitidissima Chi leaf or flower dry cream is obtained；
The manufacture method of Camellia nitidissima Chi protective skin cream is：Respectively by above-mentioned raw materials：Camellia nitidissima Chi leaf or flower dry cream, milk, stearic acid,
Glycerol monostearate, methyl hydroxybenzoate, paraffin, Fructus Citri Limoniae juice, Mel, spice, distilled water add to 100 mass %, and preparation method is：
Above-mentioned raw materials are heated to 95 DEG C of dissolvings respectively, and stirring forms emulsification system, continues stirring formation under cooling conditions rapidly
Paste product, until room temperature.
The preparation of the alkaline small group water of described pH 9.5-11 is that pure water is put in electrolysis bath, just extremely graphite,
Negative pole is platinum；
Described pure water is with natural mineral water or municipal tap water as water source, carries out the above filter element filtering in three roads to tap water and enters
Row purification process obtains pure water, or the distilled water obtained after distillation is processed.Described electrolytic process operating temperature is 50-80
DEG C, operating current is 0.9-2.0 A/cm2.
Embodiment 3
Camellia nitidissima Chi prescription for skin cream：
Camellia nitidissima Chi leaf or flower dry cream 8%；
Milk 15%；
Stearic acid 10%；
Glycerol monostearate 3%；,
Methyl hydroxybenzoate 0.5%；
Paraffin 3%；
Fructus Citri Limoniae juice 0.7%；
Mel 0.6%；
Spice 0.8%；
Distilled water adds to 100%.
Preparation process is as follows：
The process of Camellia nitidissima Chi leaf or flower dry cream is as follows：
1）It is standby that alkaline small group water is obtained first；Described alkaline small group pH 12-13；
2）Fresh Camellia nitidissima Chi leaf and fresh flower is gathered, impurity removing is removed, is dried respectively, standby；
3）Fresh Camellia nitidissima Chi leaf and fresh flower are smashed with pulverizer respectively,
4）It is put in the Camellia nitidissima Chi leaf or flower that smashes respectively using the alkaline small group water of pH 12-13, per kilogram JINHUA
Folium Camelliae sinensis or flower add 8-10 to rise alkaline small group water；, at 1-10 DEG C, time 3-5 hour, then in 10-20 for soaking temperature
DEG C temperature for the first time extract 3-5 hours, isolate extracting solution and slag；The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited；
5）It is put in slag respectively using the alkaline small group water of pH 12-13；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
5-8 rises alkaline small group water；In 10-20 DEG C of temperature control second extraction 2-3 hour, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
6）It is put in slag respectively using the alkaline small group water of pH 12-13；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
3-5 rises alkaline small group water；1-2 hours are extracted in 10-20 DEG C of temperature third time, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
7）, by alkaline extracting solution respectively cross ultrafilter membrane, ultrafiltration membrane aperture between 0.05um to 1nm, usual molecular cut off model
It is trapped among 1000～300000, then the ethanol elution with volumetric concentration 70-90%；Obtain the eluent of Camellia nitidissima Chi leaf or flower；Through
Recovery ethanol and concentration is crossed, Camellia nitidissima Chi leaf or flower dry cream is obtained；
The manufacture method of Camellia nitidissima Chi protective skin cream is：Respectively by above-mentioned raw materials：Camellia nitidissima Chi leaf or flower dry cream, milk, stearic acid,
Glycerol monostearate, methyl hydroxybenzoate, paraffin, Fructus Citri Limoniae juice, Mel, spice, distilled water add to 100 mass %, and preparation method is：
Above-mentioned raw materials are heated to 95 DEG C of dissolvings respectively, and stirring forms emulsification system, continues stirring formation under cooling conditions rapidly
Paste product, until room temperature.
The preparation of the alkaline small group water of described pH 12-13 is that pure water is put in electrolysis bath, just extremely graphite,
Negative pole is platinum；
Described pure water is with natural mineral water or municipal tap water as water source, carries out the above filter element filtering in three roads to tap water and enters
Row purification process obtains pure water, or the distilled water obtained after distillation is processed.Described electrolytic process operating temperature is 50-80
DEG C, operating current is 1.6-2.0 A/cm2.
Applicable cases of the present invention
Protective skin cream obtained in above-described embodiment tries out to 30 young woman, and 30 experimenter's great majority have pachylosiies, appearance
Easily dry, have used facial film, even if evening face notes moisturizing, but should feel not enough, particularly on working road,
The facial skin that the harmful gass that vehicle exhaust is discharged more are aggravated is compromised.On probation through these experimenters, daily 1-2 time, one
As in three days effectively, after one week, facial skin has fine and smooth, glossiness situation.30 experimenter's effective percentage are 100%, although
Individuality has difference, but facial skin improves or relatively more significant.
Application Example 1：
Certain female, people from Nanning City 32 years old, feel xerosis cutiss on the face, also wrinkle, later using the gold of the present invention after bearing child
Scented tea protective skin cream, using 7 days, can make facial skin drying regime disappear, and wrinkle is few, and skin recovers fine and smooth ruddy.
Application Example 2：
Certain actress, drills TV series in Guangxi mountain area, due to dailyization play adornment, coats thick and heavy cosmetic on the face
Product, some months get off, xerosis cutiss, also allergic conditions, it appears that the age of 25 years old, have one's late 30s, later using the present invention
Camellia nitidissima Chi protective skin cream, using 5 evenings, can make that facial muscle is full, wrinkle is few, and skin recovers fine and smooth ruddy, young beautiful.
Application Example 3：
Zhang, Guangxi people from Chongzuo City, 28 years old, guide was from the little situation for having pachylosiies, often outgoing with group, sometimes early
Go out late return, have little time face maintenance, xerosis cutiss, gloomy on the face, also wrinkle, other skin care item that is bought using shop, sense
Feel that effect is bad.Later using the Camellia nitidissima Chi protective skin cream of the present invention, it is used in conjunction 5 days, facial skin drying regime can be made to disappear, continued
Using one month, wrinkle was reduced, and skin recovers fine and smooth ruddy.
Claims (6)
1. a kind of Camellia nitidissima Chi protective skin cream, it is characterised in that including the raw material of following weight content：
Camellia nitidissima Chi leaf or flower dry cream 1-10%；
Milk 8-15%；
Stearic acid 5-12%；
Glycerol monostearate 3-8%；,
Methyl hydroxybenzoate 0.2-0.8%；
Paraffin 1-3%；
Fructus Citri Limoniae juice 0.5-1.6%；
Mel 0.2-0.8%；
Spice 0.2-1%；
Distilled water adds to 100%.
2. Camellia nitidissima Chi protective skin cream according to claim 1, it is characterised in that the process of Camellia nitidissima Chi leaf or flower dry cream is such as
Under：
1）It is standby that alkaline small group water is obtained first；Described alkaline small group pH 9-13；
2）Fresh Camellia nitidissima Chi leaf and fresh flower is gathered, impurity removing is removed, is dried respectively, standby；
3）Fresh Camellia nitidissima Chi leaf and fresh flower are smashed with pulverizer respectively,
4）It is put in the Camellia nitidissima Chi leaf or flower that smashes respectively using the alkaline small group water of pH 9-13, per kilogram JINHUA
Folium Camelliae sinensis or flower add 8-10 to rise alkaline small group water；, at 1-10 DEG C, time 3-5 hour, then in 10-20 for soaking temperature
DEG C temperature for the first time extract 3-5 hours, isolate extracting solution and slag；The extracting solution of Camellia nitidissima Chi leaf or flower is individually deposited；
5）It is put in slag respectively using the alkaline small group water of pH 9-13；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
5-8 rises alkaline small group water；In 10-20 DEG C of temperature control second extraction 2-3 hour, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
6）It is put in slag respectively using the alkaline small group water of pH 9-13；Per kilogram Camellia nitidissima Chi leaf slag or flower slag are added
3-5 rises alkaline small group water；1-2 hours are extracted in 10-20 DEG C of temperature third time, alkaline extracting solution and slag is isolated；Gold
The extracting solution of scented tea leaf or flower is individually deposited；
7）By alkaline extracting solution respectively cross ultrafilter membrane, ultrafiltration membrane aperture between 0.05um to 1nm, usual molecular cut off scope
1000～300000, then the ethanol elution with volumetric concentration 70-90%；Obtain the eluent of Camellia nitidissima Chi leaf or flower；Through
Ethanol and concentration is reclaimed, Camellia nitidissima Chi leaf or flower dry cream is obtained.
3. Camellia nitidissima Chi protective skin cream according to claim 1, it is characterised in that the manufacture method of Camellia nitidissima Chi protective skin cream is：Point
Not by above-mentioned raw materials：Camellia nitidissima Chi leaf or flower dry cream, milk, stearic acid, glycerol monostearate, methyl hydroxybenzoate, paraffin, lemon
Lemon juice, Mel, spice, distilled water add to 100 mass %, and preparation method is：Above-mentioned raw materials are heated to 95 DEG C of dissolvings respectively, and
Rapid stirring forms emulsification system, continue stirring under cooling conditions forms paste product, until room temperature.
4. Camellia nitidissima Chi protective skin cream according to claim 2, it is characterised in that the alkaline small group of described pH 9-13
The preparation of water is that pure water is put in electrolysis bath, just extremely graphite, and negative pole is platinum；
In electrolysis, the chemical equation of the two poles of the earth generation is：
Negative electrode：2H2O+2e=2OH-+H2
Anode：2H2O-4e=4H++O2.
5. Camellia nitidissima Chi protective skin cream according to claim 2, it is characterised in that described pure water is with municipal tap water as water
Source, carries out the steaming that the above filter element filtering in three roads carries out obtaining after purification process obtains pure water, or distillation process to tap water
Distilled water.
6. Camellia nitidissima Chi protective skin cream according to claim 1, it is characterised in that described electrolytic process operating temperature is 50-
80 DEG C, operating current is 0.6-2.0 A/cm2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN107213057A (en) * | 2017-06-06 | 2017-09-29 | 安徽吉乃尔电器科技有限公司 | A kind of preparation method of Camellia nitidissima whitening emulsion |
| CN109568163A (en) * | 2018-12-31 | 2019-04-05 | 中吉亚科技(广州)有限公司 | A kind of food grade moisturizing liquid and preparation method thereof |
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| CN107213057A (en) * | 2017-06-06 | 2017-09-29 | 安徽吉乃尔电器科技有限公司 | A kind of preparation method of Camellia nitidissima whitening emulsion |
| CN109568163A (en) * | 2018-12-31 | 2019-04-05 | 中吉亚科技(广州)有限公司 | A kind of food grade moisturizing liquid and preparation method thereof |
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Application publication date: 20170315 |