CN104225573A - Composition with blood sugar and blood lipid reducing function and preparation method of composition - Google Patents
Composition with blood sugar and blood lipid reducing function and preparation method of composition Download PDFInfo
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Abstract
The invention discloses composition with a blood sugar and blood lipid reducing function. The composition contains components in parts by weight as follows: 30-60 parts of alfalfa polypeptide, 20-50 parts of polygonatum odoratum polysaccharide and 5-20 parts of sea buckthorn powder. In the influence experiment to the blood sugar of alloxan diabetic mice, the composition containing the alfalfa polypeptide, the polygonatum odoratum polysaccharide and the sea buckthorn powder has a remarkable curative effect on reduction of the blood sugar level of diabetic mice. In the influence experiment to the blood lipid of high-lipid mice, the composition containing the alfalfa polypeptide, the polygonatum odoratum polysaccharide and the sea buckthorn powder has a remarkable curative effect while compared with a blank group.
Description
Technical field
The present invention relates to Medicines and Health Product, be specifically related to the medicine health product compositions of a kind of blood sugar lowering, blood fat reducing.
Background technology
Hyperglycemia, hyperlipidemia are a kind of commonly encountered diseases frequently-occurring diseases, blood glucose is too high, TC, TG, HDL-C etc. in serum are too high can the generation of induced Diabetic, hypertension, atherosclerosis coronary heart disease etc., chemical combination blood pressure lowering blood fat reducing hypoglycemic drug long-term taking in existing market has certain side effect, and it is expensive, increase the weight of the financial burden of patient, and some health product because of formula unreasonable, take effect and not obvious, therefore in market, be badly in need of a kind of effective control hyperglycemia, hyperlipidemia and the appearance of harmless medicine or heath-function product.
Alfalfa is perennial leguminous plant, and rich in proteins, cellulose, vitamin, mineral etc., containing 50 multiple nutrients material and the UGFs comprising mineral nutrient in its stem and leaf.At present, about the application of Herba Medicaginis in food, field of health care products, the domestic research mostly resting on extraction process to its leaf protein, and external by Herba Medicaginis extract suitability for industrialized production, make an addition in food, health product and supplement its effect.Related data shows that Herba Medicaginis extract has the effect reducing TC, TG level to hyperlipidemia rat, and can alleviate the lesion degree (in beautiful and that is along Ba Yaer etc., 2008) of hyperlipidemia rat liver; Alfalfa saponins extract have can resist experimental atherosclerosis in rats and reduce blood fat effect (Bing Feihong and but the Chinese is male etc., 2010), the further investigation of alfalfa extract at food, health product, medicine field is got more and more people's extensive concerning.
Rhizoma Polygonati Odorati is Liliaceae herbaceos perennial, records according to related documents, containing compositions such as body Saponin, flavone, alkaloid, polysaccharide, sterol, tannin, phlegmatic temperament and cardiotonic glycosides in Rhizoma Polygonati Odorati.The medical value of Rhizoma Polygonati Odorati is very high, all on the books at Shennong's Herbal, " book on Chinese herbal medicine justice ", Compendium of Material Medica etc.The traditional Chinese medical science is classified as YIN-tonifying drug, is used for treating scorching disease, also as strong tonic, is among the peoplely usually used in medicated diet.Recent studies proves, Rhizoma Polygonati Odorati has blood pressure lowering, blood fat reducing, improves myocardial ischemia, alleviates the effect of atherosclerotic formation, and has good preventive and therapeutic action to apoplexy, and can extend bio-longevity.CN201110414997.1 prepares other products about obtaining fragrant solomonseal rhizome polyoses in the deep-processing and colligating-using technique of Rhizoma Polygonati Odorati and fully utilizing its effect, in the application of CN200610111343.0 fragrant solomonseal rhizome polyoses in preparation treatment medicaments for coronary disease, experiment shows that fragrant solomonseal rhizome polyoses can prevention and therapy coronary heart disease effectively, particularly anti-acute myocardial ischemia, obviously can alleviate the degree of myocardial infarction, reduce myocardial infarct size and infarct size, reduce the release of myocardium enzyme.
Fructus Hippophae is called as the world the 3rd generation fruit, is widely used in health food, beverage and fruit wine industry as raw material or additive.Vitamin C, vitamin E, vitamin A, carotenoid, several amino acids, flavone and other multiple bioactive ingredients is rich in Fructus Hippophae.Often taking Fructus Hippophae can obviously allaying tiredness, excitement of refreshing oneself, to effect of old people's scalable metabolism, slow down aging.Research shows that the effective ingredient in Fructus Hippophae has antiinflammatory, anticancer, antidotal effect, Fructus Hippophae flavone can increase the effect such as coronary artery blood flow and myocardial alimentary blood flow, reduction myocardial oxygen consumption, anticoagulant, vitamin, total flavones, polyphenol etc. have anti-peroxidation and remove the effect of interior free yl, can improve body immunity and slow down aging; Vitamin, carotene, fatty acid etc. have the effect strengthening metabolism and promote damaged tissue recovery.Therefore Fructus Hippophae and extract thereof are all widely used in medicine, field of health care food etc.
In prior art, not yet openly alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder triple combination are applied to blood sugar lowering and blood fat reducing.
Summary of the invention
The object of the present invention is to provide a kind of blood sugar lowering, blood-fat reducing composition and preparation method thereof, combine for primary raw material with alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder.
The present composition is made by the raw material of following weight:
Alfalfa polypeptide 30 ~ 60 parts in this compositions, fragrant solomonseal rhizome polyoses 20 ~ 50 parts, Fructus Hippophae powder 5 ~ 20 parts.Be preferably alfalfa polypeptide 45 ~ 60 parts, fragrant solomonseal rhizome polyoses 30 ~ 45 parts, Fructus Hippophae powder 10 ~ 15 parts.Be more preferably alfalfa polypeptide 55 parts, fragrant solomonseal rhizome polyoses 35 parts, Fructus Hippophae powder 10 parts.
The preparation method of alfalfa polypeptide is:
Fresh alfalfa heating extraction alfalfa leaf protein; Dehydrated alcohol lixiviate process is adopted to remove leaf protein grass fishy smell; Two enzyme is adopted to carry out enzymolysis; Gained enzymolysis solution filters, concentrate drying, obtains alfalfa polypeptide.
The preparation method of fragrant solomonseal rhizome polyoses is:
Rhizoma Polygonati Odorati powder ungrease treatment; Microwave extraction; Water extraction; Precipitate with ethanol; After washing of precipitate drying and get final product.
The preparation method of Fructus Hippophae powder is:
Plucking wild Fructus Hippophae after getting frost is raw material, and after Fructus Hippophae cleaning treatment is clean, natural drying obtains Fructus Hippophae dry fruit, carries out secondary and picks rear pulverizing and to sieve to obtain Fructus Hippophae powder.
Above-mentioned alfalfa polypeptide, fragrant solomonseal rhizome polyoses and Fructus Hippophae powder compositions can be made into tablet, granule, hard capsule, solid beverage and oral liquid etc.
Method for preparing tablet thereof is:
Alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions 35% ~ 75%, corn starch 10 ~ 15%, microcrystalline Cellulose 15% ~ 25%, carboxymethyl cellulose 2% ~ 5%, lactose 10% ~ 15%, drop in trough type mixing machine and mix 30 minutes, add 75% ethanol as wetting agent, mix after 20 minutes, material pelletization, drying, add magnesium stearate 2 ‰, granulate, adopts tabletting machine and get final product.
Process for producing granula is:
Alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions 30% ~ 60%, add 25% ~ 35% dextrin, 5% ~ 10% lactose, white sugar 5% ~ 15%, drops in mixer and mixes 30 minutes, add 80% ethanol as wetting agent, mix 20 minutes, mixed material pelletization, drying, screening, remove coarse granule and fine powder, obtain granule.
Hard capsule preparation method is:
Alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions 15% ~ 45%, corn starch 55% ~ 85%, drop in batch mixer and mix 30 minutes, add 75% ethanol as wetting agent, mix 20 minutes, mixed material pelletization, drying, add magnesium stearate 3 ‰, granulate, capsule-filling, obtains hard capsule.
Method for preparing solid beverage thereof is:
Alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions 80% ~ 90%, white sugar 10% ~ 15%, citric acid 2 ‰ ~ 3 ‰, essence 1 ‰ ~ 3 ‰, also can not add essence, be sent into by raw material in batch mixer, abundant mixing sterilizing after 50 minutes, adopts packer quantitative separating become bag and get final product.
Specific use method for preparing beverage is:
Alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions 80%, erythritol 14%, aspartame 6 ‰, acesulfame potassium 4 ‰, citric acid 1.5 ‰, malic acid 1.5 ‰, essence 1 ‰, cools to obtain specific use beverage after the purified water allotment bottling capping sterilization that thickening compound gel is 4.5%, 80 ~ 100 times.
Product beneficial effect of the present invention is as follows:
(1) in testing the impact of alloxan diabetes mouse blood sugar, alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions have the curative effect significantly reducing blood glucose in diabetic mice level.
(2) in the impact test of high fat Mouse Blood blood fat, alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions have positive effect to improving lipid of mice level.
(3) present composition Raw alfalfa, Rhizoma Polygonati Odorati, Fructus Hippophae powder are used in combination, there is the effect of Synergistic, can be applicable to treatment and the prevention of the disease such as blood fat reducing, blood sugar lowering, simultaneously raw material be easy to draw materials, formula rationally, successful, moderate cost, easy to use, there is wide market application foreground.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
The preparation of embodiment 1 alfalfa polypeptide
Get initial bloom stage alfalfa (second batch ~ the 3rd batch) top 8cm ~ 10cm young stem and leaf part for processing raw material, pick to remove and turn yellow, wilt, rot, damaged by vermin leaf and other impurity, clean up after (2 times ~ 3 times) drain with tap water and be cut into 2cm ~ 3cm segment, alfalfa young stem and leaf in mass ratio: water=1: 2 put into tissue mashing machine making beating process 5min, after taking-up, whole juice and alfalfa residue are moved in colloid mill, gear arranges the thinnest card degree post processing 10min, period drops into the water of one times of alfalfa weight in colloid mill, and adopt 200 order nylon filtering cloths to filter to obtain alfalfa juice, by alfalfa juice 10000ml direct heating, constantly mechanical agitation is carried out in heating process, when temperature rises to 80 DEG C, isothermal holding 10min obtains bottle green floccule precipitation, supernatant is removed after standing separation, floccule is deposited in centrifuge and obtains centrifugal sediment with 4000r/min centrifugal treating 10min, under normal temperature condition, natural drying obtains alfalfa leaf protein, and its albumen quality mark is 68.16%.Adopting 120 mesh sieves to pulverize gained alfalfa protein, is 1: 8 at alfalfa leaf protein and dehydrated alcohol mass ratio, and at extraction temperature 85 DEG C, lixiviate process 10h, the alfalfa leaf protein obtained canescence of light color, albumen quality mark is 67.13%.Alfalfa protein after decoloration deodorization process is put into enzymatic vessel, in enzymatic vessel, the mass ratio of alfalfa protein and water is 1: 1, treat tank Nei Wenduda 55 DEG C, under natural ph condition, add the Protamex enzyme (letter bio tech ltd of Chinese Novi) being equivalent to alfalfa-leaf protein by weight 2.0 ‰, add the Flavourzyrne1000L enzyme (letter bio tech ltd of Chinese Novi) being equivalent to alfalfa-leaf protein by weight 1.0 ‰ simultaneously, it is 55 DEG C in temperature, enzymolysis processing 3h under natural ph condition, enzyme denaturing 60min under 100 DEG C of high temperature, collecting by filtration enzymolysis solution.Use dual-effect concentrator that the enzymolysis solution of collection is concentrated into concentrated solution relative density for 1.10g/ml, inlet temperature is adopted to be 185 DEG C, temperature of outgoing air is that the spray drying condition of 80 DEG C carries out spraying dry, gained polypeptide dry powder moisture content < 4.0%, carries out pulverizing and crosses 120 mesh sieves and put into specified containers and store by gained dry powder.
By the alfalfa polypeptide powder that above technique is obtained, after sampling, analytical test, content of peptides is 74.65%, and products obtained therefrom is pale powder, be easy to dissolve, dissolve after abnormal smells from the patient pure and fresh, not there is careless fishy smell, but light grass fragrance, almost without bitterness sense.
The preparation of embodiment 2 fragrant solomonseal rhizome polyoses
Microwave-assisted water extraction is adopted to obtain fragrant solomonseal rhizome polyoses: to get the oven dry of a certain amount of Rhizoma Polygonati Odorati and beat powder, get after defat 500g defat dry powder and pure water with 1: 30 solid-liquid ratio mix, temperature rises to 75 DEG C, with microwave power 100w process 5min, stop microwave, proceed water extraction process 60min, centrifuge 3000r/min process 10min is adopted to Microwave Water extract, adopt 80% ethanol precipitate with ethanol process 45min, stratification obtains precipitate, adopt acetone, washed with diethylether volatilize acetone, ether successively, the lyophilization of gained material obtains fragrant solomonseal rhizome polyoses extract.
The preparation of embodiment 3 Fructus Hippophae powder
The wild Fructus Hippophae of plucking after selecting frost is raw material, the impurity such as dirt, leaves is removed with clear water after being plucked by Fructus Hippophae, the cleaning of continuation water is clean to Fructus Hippophae, naturally dry after Fructus Hippophae is drained away the water, light should not avoid dry fruit color excessively dark (in dark brown) to affect quality excessively enough, do not stop in dry in the sun process to stir to avoid rotting, after dry in the sun, a small amount of impurity of dry Fructus Hippophae artificial removal is as tree stalk, leaves etc., Fructus Hippophae dry fruit is put into pulverizer to beat powder and cross 60 mesh sieves and obtain Fructus Hippophae powder, upper strata residue carries out extraction and obtains other Fructus Hippophae extract.Gained Fructus Hippophae powder is that brown powder, abnormal smells from the patient are pure and fresh, pure in mouth feel.
The preparation that embodiment 4 is primary raw material blood sugar lowering, blood-fat reducing composition with alfalfa polypeptide powder, fragrant solomonseal rhizome polyoses, Fructus Hippophae
Take the alfalfa polypeptide powder of certain part by weight, fragrant solomonseal rhizome polyoses extract and Fructus Hippophae powder respectively, mix according to alfalfa polypeptide powder, fragrant solomonseal rhizome polyoses extract and Fructus Hippophae powder 30 ~ 60: 25 ~ 50: 5 ~ 20 weight portion and get final product.
Beneficial effect of the present invention is proved below by way of blood sugar lowering, blood fat reducing pharmacodynamics:
Test example 1
Alfalfa polypeptide (A), fragrant solomonseal rhizome polyoses (B), Fructus Hippophae powder (C) blood sugar lowering, blood-fat reducing composition are on the impact of alloxan diabetes mouse blood sugar
Experiment healthy mice 70, separate 10 at random for Normal group (normal saline 0.5ml/ only), the not tight water 24h of all the other 60 mice fasting, lumbar injection alloxan 180mg/kg is all carried out to 60 mices, after injection, 72h measures blood glucose to mouse orbit blood sampling, and blood sugar concentration is diabetic mice higher than 11.2mol/L.60 diabetic mices are divided into 6 groups at random: the blank group of artificial diabetes (normal saline 0.5ml/ only), the suitable health group (100mg/kg) of sugar, each 2500mg/kg of compositions 1 ~ 4 dosage.Compositions 1 (A: B: C=45: 35: 15), compositions 2 (A: B: C=30: 50: 20), compositions 3 (A: B: C=60: 20: 5), compositions 4 (A: B: C=55: 35: 10) every morning 8:00 ~ 9:00 gavage is taken, continuous 30d.Get blood from mouse orbit rear vein beard after fasting 12h and survey blood glucose value, the results are shown in Table 1.
Table 1 present composition is on the impact of DM mouse blood sugar level
| Group | Dosage/mg/kg | n | Blood glucose/mol/L |
| Normal mouse matched group | —— | 10 | 6.55±1.56 |
| The blank group of diabetes model | —— | 10 | 32.54±4.05 |
| The suitable health group of sugar | 5 | 10 | 29.12±3.05**Δ |
| Compositions 1 | 2500 | 10 | 29.35±3.22**Δ |
| Compositions 2 | 2500 | 10 | 30.38±3.78**Δ |
| Compositions 3 | 2500 | 10 | 30.56±4.24*Δ |
| Compositions 4 | 2500 | 10 | 28.37±3.26**ΔΔ |
Note: compare * P < 0.05, * * P < 0.01 with the blank group of diabetes model; Fit health group with sugar and compare Δ P < 0.05, Δ Δ P < 0.01
Table 1 shows, model group blood glucose in diabetic mice concentration far above 11.2mol/L, apparently higher than normal group.Compared with model group, each contrast groups mouse blood sugar concentration all comparatively model group blood glucose to some extent obviously reduces, wherein compositions group data show its effect and sugar to fit health group suitable, illustrate that alfalfa polypeptide, fragrant solomonseal rhizome polyoses and Fructus Hippophae powder compositions can significantly reduce blood glucose in diabetic mice level.
Test example 2
Alfalfa polypeptide (A), fragrant solomonseal rhizome polyoses (B), Fructus Hippophae powder (C) blood sugar lowering, blood-fat reducing composition are on the impact of high fat Mouse Blood blood fat
Choose healthy mice 70, separate 10 at random as Normal group, all the other 60 mouse are raised with high lipid food, and normal water, modeling 16d, obtains model group.Model mice is divided into 6 groups at random: experimental model matched group, positive drug zhibituo group (350mg/kg), each 2500mg/kg of compositions 1-4 dosage group.Compositions 1 (A: B: C=45: 35: 15), compositions 2 (A: B: C=30: 50: 20), compositions 3 (A: B: C=60: 20: 5), compositions 4 (A: B: C=55: 35: 10).Test positives medicine zhibituo group, compositions 1-4 dosage group is by above-mentioned dosage gastric infusion, blank group and experimental model matched group are to the water of same volume, every morning 9:00 takes 1 time, continuous 30d, get TC, TG, HDL-C, LDL-C of each mice of hematometry, each group data represent with means standard deviation, carry out t test between group.Experimental result is in table 2.
Table 2 present composition is on the impact of DM lipid of mice level
Note: compare * P < 0.05, * * P < 0.01 with experimental model matched group; Δ P < 0.05 is compared, Δ Δ P < 0.01 with zhibituo group
Table 2 shows, compared with experimental model control group mice, each sample group mice TG level, TC level, HDL-C level and LDL-C level are all lower than model control group, compared with normal mouse matched group, take each Testing index of zhibituo lipid of mice comparatively model control group have remarkable reduction, other sample sets also all has improvement in various degree, wherein the corresponding Testing index of compositions group is suitable with zhibituo group effect, illustrates that alfalfa polypeptide, fragrant solomonseal rhizome polyoses and Fructus Hippophae powder compositions can have positive effect to improving lipid of mice level.
Embodiment 4
The preparation method of a kind of blood sugar lowering, blood fat reducing tablet
(weight proportion is alfalfa polypeptide 55 parts, fragrant solomonseal rhizome polyoses 35 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 10 parts) 45%, corn starch 10%, microcrystalline Cellulose 15%, carboxymethyl cellulose 2%%, lactose 10%, drop in trough type mixing machine and mix 30 minutes, add 75% ethanol as wetting agent, mix after 20 minutes, mixed material 16 mesh sieve conventional methods are granulated, dry, add magnesium stearate 2 ‰, granulate, adopt tabletting machine and get final product.
Embodiment 5
The preparation method of a kind of blood sugar lowering, blood fat reducing tablet
(weight proportion is alfalfa polypeptide 55 parts, fragrant solomonseal rhizome polyoses 35 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 10 parts) 60%, corn starch 15%, microcrystalline Cellulose 20%, carboxymethyl cellulose 3%, lactose 15%, drop in trough type mixing machine and mix 30 minutes, add 75% ethanol as wetting agent, mix after 20 minutes, mixed material 16 mesh sieve conventional methods are granulated, dry, add magnesium stearate 2 ‰, granulate, adopt tabletting machine and get final product.
Embodiment 6
The preparation method of a kind of blood sugar lowering, blood fat reducing granule
(weight proportion is alfalfa polypeptide 45 parts, fragrant solomonseal rhizome polyoses 30 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 10 parts) 50%, add 25% dextrin, 6% lactose, white sugar 10%, drop in mixer and mix 30 minutes, add 80% ethanol as wetting agent, mix 20 minutes, mixed material is granulated according to a conventional method, drying, screening, removes coarse granule and fine powder, obtains granule.
Embodiment 7
The preparation method of a kind of blood sugar lowering, blood fat reducing granule
(weight proportion is alfalfa polypeptide 40 parts, fragrant solomonseal rhizome polyoses 25 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 15 parts) 40%, add 20% dextrin, 10% lactose, white sugar 15%, drop in mixer and mix 30 minutes, add 80% ethanol as wetting agent, mix 20 minutes, mixed material is granulated according to a conventional method, drying, screening, removes coarse granule and fine powder, obtains granule.
Embodiment 8
The preparation method of a kind of blood sugar lowering, blood fat reducing hard capsule
(weight proportion is alfalfa polypeptide 35 parts, fragrant solomonseal rhizome polyoses 20 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 5 parts) 45%, corn starch 60%, drops in batch mixer and mixes 30 minutes, add 75% ethanol as wetting agent, mix 20 minutes, mixed material pelletization, drying, add magnesium stearate 3 ‰, granulate, capsule-filling, obtains hard capsule.
Embodiment 9
The preparation method of a kind of blood sugar lowering, blood fat reducing hard capsule
(weight proportion is alfalfa polypeptide 55 parts, fragrant solomonseal rhizome polyoses 30 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 15 parts) 35%, corn starch 75%, drops in batch mixer and mixes 30 minutes, add 75% ethanol as wetting agent, mix 20 minutes, mixed material pelletization, drying, add magnesium stearate 3 ‰, granulate, capsule-filling, obtains hard capsule.
Embodiment 10
The preparation method of a kind of blood sugar lowering, blood fat reducing solid beverage
(weight proportion is alfalfa polypeptide 50 parts, fragrant solomonseal rhizome polyoses 40 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 15 parts) 85%, white sugar 15%, citric acid 2 ‰, essence 1 ‰, raw material is sent in batch mixer, fully mixing sterilizing after 50 minutes, adopt packer quantitative separating become bag and get final product.
Embodiment 11
The preparation method of a kind of blood sugar lowering, blood fat reducing specific use beverage
(weight proportion is alfalfa polypeptide 55 parts, fragrant solomonseal rhizome polyoses 40 parts for alfalfa polypeptide, fragrant solomonseal rhizome polyoses, Fructus Hippophae powder compositions, Fructus Hippophae powder 12 parts) 80%, erythritol 14%, aspartame 6 ‰, acesulfame potassium 4 ‰, citric acid 1 ‰, malic acid 1 ‰, essence 1 ‰, cools to obtain specific use beverage after 4.5%, the 100 times of purified water allotment bottling capping sterilizations of thickening compound gel.
Embodiment 12
Below by case, blood sugar lowering provided by the invention, blood-fat reducing composition curative effect are described:
(1) physical data
50 ~ 70 years old object of observation age of including in, average 61 years old.Male 152 people, women 136 people.The object of observation all does health check-up, all without serious organ disease.
(2) case standard is tested
Hyperglycemia has following clinical manifestation: frequent micturition is dewatered, extreme thirst, nausea and vomiting, abdominal discomfort, xerosis cutis, and blood sugar test value raises, and glucose in urine positive test is reacted.
Hyperlipidemia has following clinical manifestation: dizziness, spiritlessness and weakness, hypertension, insomnia forgetfulness, numb limbs and tense tendons, uncomfortable in chest, cardiopalmus, and part is with overweight and obesity.
(3) administrated method
Obtain tablet by embodiment 4, every day 3 times, each 2,30 minutes ante cibum are oral.
(4) observational technique
Hyperglycemia main detection symptom: blood sugar test value height, glucose in urine test reaction, thirsty frequent micturition improves situation.
Hyperlipidemia main detection symptom: dizzy improvement situation, blood pressure, chest distress and palpitation symptoms improves situation, body weight change situation.
Safety: select some cases to carry out blood, urine, feces routine test.
(5) evaluation criterion
Recovery from illness: symptom is all eliminated.
Effective: cardinal symptom has clear improvement.
Effective: cardinal symptom has some improvement.
Invalid: cardinal symptom is without improvement.
(6) therapeutic outcome (analyzing to take 3 months)
| ? | Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| Hyperglycemia | 112 | 18 | 37 | 46 | 11 | 90.2 |
| Hyperlipidemia | 96 | 13 | 22 | 46 | 15 | 84.4 |
| Both syndromes | 80 | 10 | 18 | 45 | 7 | 91.3 |
Claims (8)
1. blood sugar lowering, a blood-fat reducing composition, is characterized in that, containing alfalfa polypeptide, and fragrant solomonseal rhizome polyoses and Fructus Hippophae powder.
2. blood sugar lowering according to claim 1, blood-fat reducing composition, is characterized in that, alfalfa polypeptide, and fragrant solomonseal rhizome polyoses and Fructus Hippophae powder weight portion are: alfalfa polypeptide powder 30 ~ 60 parts, fragrant solomonseal rhizome polyoses 20 ~ 50 parts, Fructus Hippophae powder 5 ~ 20 parts.
3. blood sugar lowering according to claim 2, blood-fat reducing composition, is characterized in that, alfalfa polypeptide 45 ~ 60 parts, fragrant solomonseal rhizome polyoses 30 ~ 45 parts, Fructus Hippophae powder 10 ~ 15 parts.
4. blood sugar lowering according to claim 3, blood-fat reducing composition, is characterized in that, alfalfa polypeptide 55 parts, fragrant solomonseal rhizome polyoses 35 parts, Fructus Hippophae powder 10 parts.
5., according to claim 1-4 arbitrary described blood sugar lowering, blood-fat reducing composition, it is characterized in that, the preparation method of alfalfa polypeptide is: fresh alfalfa heating extraction alfalfa leaf protein; Dehydrated alcohol lixiviate process is adopted to remove leaf protein grass fishy smell; Two enzyme is adopted to carry out enzymolysis; Gained enzymolysis solution filters, concentrate drying, obtains alfalfa polypeptide.
6., according to claim 1-4 arbitrary described blood sugar lowering, blood-fat reducing composition, it is characterized in that, the preparation method of fragrant solomonseal rhizome polyoses is: Rhizoma Polygonati Odorati powder ungrease treatment; Microwave extraction; Water extraction; Precipitate with ethanol; After washing of precipitate drying and get final product.
7., according to claim 1-4 arbitrary described blood sugar lowering, blood-fat reducing composition, it is characterized in that, described compositions makes tablet, granule, hard capsule, solid beverage or oral liquid.
8. preparing the application in blood sugar lowering, blood fat reducing medicine according to the arbitrary described blood sugar lowering of claim 1-7, blood-fat reducing composition.
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| CN105747222A (en) * | 2016-03-17 | 2016-07-13 | 天津元恒德科技有限公司 | Composition having effects of lowering blood fat and reducing weight and application |
| CN106418093A (en) * | 2016-06-07 | 2017-02-22 | 张英 | Functional drink using bamboo extract and edible flowers as core components |
| CN109938252A (en) * | 2019-04-01 | 2019-06-28 | 广东河溏农业科技有限公司 | A kind of anti-aging, hypoglycemic food leaf grass rice row's powder and preparation method thereof |
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| CN105747222A (en) * | 2016-03-17 | 2016-07-13 | 天津元恒德科技有限公司 | Composition having effects of lowering blood fat and reducing weight and application |
| CN106418093A (en) * | 2016-06-07 | 2017-02-22 | 张英 | Functional drink using bamboo extract and edible flowers as core components |
| CN109938252A (en) * | 2019-04-01 | 2019-06-28 | 广东河溏农业科技有限公司 | A kind of anti-aging, hypoglycemic food leaf grass rice row's powder and preparation method thereof |
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Application publication date: 20141224 |