CN105380858B - Mosquito repellent bacterio static itching-relieving spray - Google Patents

Mosquito repellent bacterio static itching-relieving spray Download PDF

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CN105380858B
CN105380858B CN201510893400.4A CN201510893400A CN105380858B CN 105380858 B CN105380858 B CN 105380858B CN 201510893400 A CN201510893400 A CN 201510893400A CN 105380858 B CN105380858 B CN 105380858B
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essential oil
mosquito
repellent
relieving
combination
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CN105380858A (en
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孟凡奎
王健斌
龚贻洲
张燕华
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Wuhan Jinghong Technology Co ltd
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Wuhan Jinghong Wanfangtang Medical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4453Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/738Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00Formulations or additives for perfume preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
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Abstract

The invention discloses a kind of mosquito repellent bacterio static itching-relieving sprays comprising mosquito-repellent essential oil combination, an essential oil clathrate and bacterio static itching-relieving combination;The mosquito-repellent essential oil combination and the proportioning of the essential oil clathrate are 1:10~1:8, the essential oil clathrate includes the mosquito-repellent essential oil combination, and the proportioning that the mosquito-repellent essential oil combination is combined with the bacterio static itching-relieving is 3:2~2:1;Wherein, the mosquito-repellent essential oil combination includes 0.01~10 part of citronella oil, 0.01~10 part of lavender oil, 0.01~10 part of eucalyptus oil, 0.01~10 part of menthol;The essential oil clathrate includes 1~60 part of beta cyclodextrin;The bacterio static itching-relieving combination includes 0.01~10 part of thymol, 0.01~10 part of folium artemisiae argyi alcohol extracting thing, 0.01~10 part of dyclonine hydrochloride.The essential oil clathrate will achieve the effect that lasting mosquito repellent after mosquito-repellent essential oil combination inclusion, and bacterio static itching-relieving combination can be realized and antipruritic rapidly attack energy.

Description

Mosquito repellent bacterio static itching-relieving spray
Technical field
The present invention relates to a kind of sprays, and in particular to a kind of mosquito repellent bacterio static itching-relieving spray.
Background technology
The active ingredient of traditional mosquito-proof spray is mostly farm chemical ingredients, although farm chemical ingredients can have the function that it is mosquito-proof, It is that very strong potential toxic side effect might have to human body, especially children.In addition, existing mosquito-repellent antipruritic class product presses work( Two classifications can be broadly divided into, one kind is mosquito repellent type, and another kind of is antipruritic type.And the spray of mosquito repellent type and antipruritic type to be reached Effect is different, and mosquito repellent type spray requires the duration long, and antipruritic type spray requires can be rapid antipruritic.How to match and a kind of energy is provided It is those skilled in the art's technical problem urgently to be resolved hurrily always to stablize and effectively continue mosquito repellent and the rapid antipruritic spray of energy.
Invention content
In view of this, mosquito repellent and the rapid antipruritic mosquito repellent bacterio static itching-relieving spray of energy can be continued it is necessary to provide a kind of.
A kind of mosquito repellent bacterio static itching-relieving spray comprising mosquito-repellent essential oil combination, an essential oil clathrate and a bacterio static itching-relieving group It closes;The mosquito-repellent essential oil combination and the proportioning of the essential oil clathrate are 1:10~1:8, the essential oil clathrate includes the drive Mosquito essential oil combines, and the proportioning that the mosquito-repellent essential oil combination is combined with the bacterio static itching-relieving is 3:2~2:1;Wherein, the mosquito repellent essence Oil combination includes 0.01~10 part of citronella oil, 0.01~10 part of lavender oil, 0.01~10 part of eucalyptus oil, 0.01~10 portion of peppermint Brain;The essential oil clathrate includes 1~60 part of beta cyclodextrin;The bacterio static itching-relieving combination includes 0.01~10 part of thymol, 0.01~10 part of folium artemisiae argyi alcohol extracting thing, 0.01~10 part of dyclonine hydrochloride.
Mosquito repellent bacterio static itching-relieving spray provided by the invention by the way that mosquito-repellent essential oil is combined, essential oil clathrate and bacterio static itching-relieving group It closes and integrates, the essential oil clathrate will achieve the effect that lasting mosquito repellent, and the suppression after mosquito-repellent essential oil combination inclusion The antipruritic combination of bacterium, which can be realized, rapid antipruritic attacks energy.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, is not used to Limit the present invention.
The present invention provides a kind of mosquito repellent bacterio static itching-relieving spray comprising mosquito-repellent essential oil combination, an essential oil clathrate and one Bacterio static itching-relieving combines;The mosquito-repellent essential oil combination and the proportioning of the essential oil clathrate are 1:10~1:8, the essential oil clathrate The mosquito-repellent essential oil combination is included, the proportioning that the mosquito-repellent essential oil combination is combined with the bacterio static itching-relieving is 3:2~2:1.
In present embodiment, the mosquito-repellent essential oil combination and the proportioning of the essential oil clathrate are 1:9, the mosquito-repellent essential oil It is 7 to combine the proportioning combined with the bacterio static itching-relieving:4.
Mosquito compares the smell of detest and the mankind compare the smell of hobby by volatilizing for mosquito-repellent essential oil combination, to It makes it possible to disperse mosquito and can set the mind at rest or calm mood.The mosquito-repellent essential oil combination includes 0.01~10 part of citronella oil, 0.01~10 part of lavender oil, 0.01~10 part of eucalyptus oil, 0.01~10 part of menthol.
The essential oil clathrate is for making the mosquito-repellent essential oil combination achieve the effect that slow release, to improve the mosquito repellent The time of the lasting mosquito repellent of essential oil combination.The essential oil clathrate includes 1~60 part of beta cyclodextrin.
Essential oil includes condition:Temperature:40~80 DEG C;Mixing time:1~5h;Solvent:Ethyl alcohol;Process:Prepare β-CD saturations Aqueous solution;It is heated up to 40~80 DEG C of constant temperature;Essential oil combination is dissolved in 1 times of alcohol solvent;It opens under stirring condition slowly by essential oil Combination solution is added dropwise wherein, continues 1~5h of stirring;It is cold to set 12~48h;It filters;Low temperature drying.
Bacterio static itching-relieving combination carries out anti-inflammatory to prevent inflammation infection for the mankind after mosquito bite, additionally by The effect of epidermis anesthesia is antipruritic.The bacterio static itching-relieving combination includes 0.01~10 part of thymol, 0.01~10 part of folium artemisiae argyi alcohol extracting Take object, 0.01~10 part of dyclonine hydrochloride.
The mosquito repellent bacterio static itching-relieving spray further includes 0.01~10 part of borneol, 0.1~80 portion of edible alcohol, 0.1~50 part Propylene glycol, 0.1~50 part of ethyl lactate, 0.01~10 part of Crodaret;1.0~95.0 parts of purified waters.
The prewired mixing of folium artemisiae argyi alcohol extracting thing and proper amount of edible alcohol in above-mentioned composition forms water phase after standing;Thyme Phenol, dyclonine hydrochloride, citronella oil, eucalyptus oil, lavender oil, borneol, menthol propylene glycol, alcohol and ethyl lactate mixing Dissolving forms oil phase completely;Then water oil phase is mixed, is stood, filtering.
Embodiment 1
The mosquito repellent bacterio static itching-relieving spray include 2 parts of citronella oils, 3 parts of lavender oils, 2 parts of eucalyptus oils, 1 part of menthol, 20 Part beta cyclodextrin, 2 parts of thymols, 3 parts of folium artemisiae argyi alcohol extracting things, 3 parts of dyclonine hydrochlorides, 4 parts of borneols, 20 portions of edible alcohols, 10 Part propylene glycol, 10 parts of ethyl lactates, 2 parts of Crodarets;37 parts of purified waters.
Embodiment 2
The mosquito repellent bacterio static itching-relieving spray include 3 parts of citronella oils, 3 parts of lavender oils, 4 parts of eucalyptus oils, 1 part of menthol, 32 Part beta cyclodextrin, 3 parts of thymols, 2 parts of folium artemisiae argyi alcohol extracting things, 3 parts of dyclonine hydrochlorides, 2 parts of borneols, 15 portions of edible alcohols, 6 Part propylene glycol, 6 parts of ethyl lactates, 1 part of Crodaret;38 parts of purified waters.
Embodiment 3
The mosquito repellent bacterio static itching-relieving spray include 1 part of citronella oil, 2 parts of lavender oils, 1 part of eucalyptus oil, 1 part of menthol, 15 Part beta cyclodextrin, 1 part of thymol, 2 parts of folium artemisiae argyi alcohol extracting things, 1 part of dyclonine hydrochloride, 2 parts of borneols, 5 portions of edible alcohols, 5 parts Propylene glycol, 5 parts of ethyl lactates, 1 part of Crodaret;72 parts of purified waters.
Embodiment 4
The mosquito repellent bacterio static itching-relieving spray include 4 parts of citronella oils, 6 parts of lavender oils, 4 parts of eucalyptus oils, 5 parts of menthols, 40 Part beta cyclodextrin, 7 parts of thymols, 4 parts of folium artemisiae argyi alcohol extracting things, 5 parts of dyclonine hydrochlorides, 1 part of borneol, 1 portion of edible alcohol, 1 part Propylene glycol, 1 part of ethyl lactate, 1 part of Crodaret;20 parts of purified waters.
Mosquito repellent bacterio static itching-relieving spray provided by the invention by the way that mosquito-repellent essential oil is combined, essential oil clathrate and bacterio static itching-relieving group It closes and integrates, the essential oil clathrate will achieve the effect that lasting mosquito repellent, and the suppression after mosquito-repellent essential oil combination inclusion The antipruritic combination of bacterium, which can be realized, rapid antipruritic attacks energy.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.

Claims (6)

1. a kind of mosquito repellent bacterio static itching-relieving spray comprising mosquito-repellent essential oil combination, an essential oil clathrate and bacterio static itching-relieving combination; The mosquito-repellent essential oil combination and the proportioning of the essential oil clathrate are 1:10~1:8, the essential oil clathrate includes the mosquito repellent Essential oil combines, and the proportioning that the mosquito-repellent essential oil combination is combined with the bacterio static itching-relieving is 3:2~2:1;Wherein, the mosquito-repellent essential oil Combination includes 0.01~10 part of citronella oil, 0.01~10 part of lavender oil, 0.01~10 part of eucalyptus oil, 0.01~10 portion of peppermint Brain;The essential oil clathrate includes 1~60 part of beta cyclodextrin;The bacterio static itching-relieving combination includes 0.01~10 part of thymol, 0.01~10 part of folium artemisiae argyi alcohol extracting thing, 0.01~10 part of dyclonine hydrochloride;Essential oil includes condition:Temperature:40~80 DEG C;Stirring Time:1~5h;Solvent:Ethyl alcohol;Process:Prepare β-CD saturated aqueous solutions;It is heated up to 40~80 DEG C of constant temperature;Essential oil combination is dissolved in 1 In times alcohol solvent;It opens and slowly essential oil combination solution is added dropwise wherein under stirring condition, continue 1~5h of stirring;It is cold set 12~ 48h;It filters;Low temperature drying.
2. mosquito repellent bacterio static itching-relieving spray according to claim 1, which is characterized in that the mosquito repellent bacterio static itching-relieving spray also wraps Include 0.01~10 part of borneol, 0.1~80 portion of edible alcohol, 0.1~50 part of propylene glycol, 0.1~50 part of ethyl lactate, 0.01~10 Part Crodaret;1.0~95.0 parts of purified waters.
3. mosquito repellent bacterio static itching-relieving spray according to claim 1, which is characterized in that the mosquito-repellent essential oil combination and the essence The proportioning of oily inclusion compound is 1:9, the proportioning that the mosquito-repellent essential oil combination is combined with the bacterio static itching-relieving is 7:4.
4. mosquito repellent bacterio static itching-relieving spray according to claim 1, which is characterized in that the mosquito-repellent essential oil combination includes 4 parts Citronella oil, 6 parts of lavender oils, 4 parts of eucalyptus oils, 5 parts of menthols.
5. mosquito repellent bacterio static itching-relieving spray according to claim 1, which is characterized in that the essential oil clathrate includes 40 parts of β Cyclodextrin.
6. mosquito repellent bacterio static itching-relieving spray according to claim 1, which is characterized in that the bacterio static itching-relieving combination includes 7 parts Thymol, 4 parts of folium artemisiae argyi alcohol extracting things, 5 parts of dyclonine hydrochlorides.
CN201510893400.4A 2015-12-04 2015-12-04 Mosquito repellent bacterio static itching-relieving spray Active CN105380858B (en)

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CN106215229A (en) * 2016-07-22 2016-12-14 苏州瑞科四通新材料有限公司 A kind of antibacterial liquid Wound-protection liquid and preparation method thereof
CN106581498A (en) * 2017-02-10 2017-04-26 李忠泽 Anti-mosquito antibacterial agent
CN108685987A (en) * 2018-06-25 2018-10-23 上海凯宝药业股份有限公司 A kind of Chinese medicine composition and its preparation method and application
CN108721125A (en) * 2018-07-17 2018-11-02 浙江优全护理用品科技有限公司 A kind of antipruritic wet tissue of Portable mosquito-dispelling
CN109453146B (en) * 2018-12-27 2021-05-14 佛山市南海东方澳龙制药有限公司 Pathogenic microorganism resisting composition and preparation method and application thereof
CN109819980B (en) * 2019-04-02 2021-04-06 哈工大机器人(山东)智能装备研究院 Slow-release mosquito-proof insect-repellent incense bead and preparation method thereof
CN110251435B (en) * 2019-07-24 2022-01-11 黑龙江省科学院高技术研究院 Essential oil spray with mosquito-repelling and itching-relieving effects and preparation method thereof
CN111481489A (en) * 2020-05-20 2020-08-04 四川绿色本草科技发展有限公司 Ligusticum wallichii extract with mosquito repelling and itching relieving effects and application thereof
CN112494388A (en) * 2020-12-16 2021-03-16 江苏耐雀生物工程技术有限公司 Nonalcoholic spray for repelling mosquitoes and relieving itching and preparation method thereof

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CN101186772B (en) * 2007-12-04 2011-04-27 华南农业大学 Helminthic emulsion paint and preparation method thereof
CN102441037A (en) * 2010-09-30 2012-05-09 中国人民解放军总医院 Mosquito-repelling and itching-relieving cream
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