CN106581498A - Anti-mosquito antibacterial agent - Google Patents
Anti-mosquito antibacterial agent Download PDFInfo
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- CN106581498A CN106581498A CN201710072864.8A CN201710072864A CN106581498A CN 106581498 A CN106581498 A CN 106581498A CN 201710072864 A CN201710072864 A CN 201710072864A CN 106581498 A CN106581498 A CN 106581498A
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- antibacterial
- anophelifuge
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- mosquito
- mentholum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses an anti-mosquito antibacterial agent. The anti-mosquito antibacterial agent comprises, by weight, 0.1-0.3 parts of an antibacterial agent, 0.5-1.5 parts of a menthol solution, 1-3 parts of plant extract and 20-40 parts of purified water. The anti-mosquito antibacterial agent is weakly alkaline, and penetrates skins to effectively neutralize formic acid in ants and mosquitoes and rapidly kill bacteria and viruses, and menthol slices used as a heat clearing and detoxifying agent and a penetrating agent have synergism; various plant essential oils have synergism to effectively resist mosquitoes; cetyl dimethyl amine oxide used as a cationic surfactant forms a protection film on the surface of an object and skins in order to prolong the anti-mosquito time for 4-6 h, and also has a moisturizing effect on the skins; and the anti-mosquito antibacterial agent effectively prevents denge fever, malaria and other diseases propagated by mosquitoes, and also has a very good treatment effect on mosquito bites.
Description
Technical field
The present invention relates to a kind of antibacterial, more specifically, more particularly to a kind of anophelifuge antibacterial.
Background technology
The dermatitis that mosquito bite causes in insect dermatitiss is modal.Mosquito stabs skin by its mouthpart, its saliva
Liquid or venom invade skin, and due to containing various antigenic components in the saliva of mosquito or the leachate of poison gland, these antigens are entering
Atopic reaction can be produced with antibody after entering human body skin and cause inflammation.When serious, indivedual infant local produce bulla, bleeding
The severe reactions such as property necrosis.Existing antibacterial only serves antibacterial action, it is impossible to prevent the disease of the mosquitoes spreads such as dengue fever, malaria
Disease, while there is no therapeutical effect to mosquito bite.
The content of the invention
Present invention aims to above-mentioned the deficiencies in the prior art, there is provided a kind of anophelifuge antibacterial.
The technical scheme is that what is be achieved in that：
A kind of anophelifuge antibacterial, including the raw material of following weight portion：Including the raw material of following weight portion：Antibacterial 0.1-
0.3 part, Mentholum solution 0.5-1.5 parts, plant extract 1-3 parts, and purified water 20-40 part.
Preferably, the raw material also including following weight portion：Borneolum Syntheticum 0.05-0.15 parts.
Preferably, the raw material also including following weight portion：Cationic surfactant 0.5-1.5 parts.
Preferably, the antibacterial is that myristyl benzyl dimethyl ammonium chloride and DDAC are compound
Thing, its weight ratio are 3: 2.
Preferably, the Mentholum solution includes Mentholum and solubilizing agent, and wherein Mentholum, the weight ratio of solubilizing agent are 1:
3。
Preferably, the preferred Oleum Ricini PEG-40 of the solubilizing agent.
Preferably, the plant extract includes lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) essence
Oil, eucalyptus quintessence oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2.
Preferably, the preferred cetyl dimethyl amine oxide of the cationic surfactant.
Preferably, the pH value of described anophelifuge antibacterial is 7.5-7.9.
Antibacterial, wherein myristyl benzyl dimethyl ammonium chloride produce cationic reactive groups in dissociation in water, have
The performances such as sterilization, emulsifying, antistatic, softness, DDAC are the broad-spectrum biological agent for killing of modern safety, effectively
Gram positive bacteria and negative bacterium, funguses, mycete are killed, effectively suppresses the enveloped viruses such as hepatitis B, HIV；It is miscellaneous to anion
Matter, hard water have very high toleration, still play in highly organic dirt such as bloodstain, albumen stain efficient, excellent table live and
Wettability, can control insecticide disease；The formic acid of Formica fusca mosquito is neutralized after penetrating into skin effectively, while quickly killing bacterial diseases
Poison.
Mentholum, Mentholum are a kind of chemical agents, are extracted in the leaf and stem by Herba Menthae, white crystal, molecular formula
C10H200, is the main component in Herba Menthae and lavender quintessence oil, and Mentholum and racementhol can be employed as toothpaste, perfume, drink
The odorant of material and confection etc..Pharmaceutically it is being used as excitantss, is acting on skin or mucosa, have refrigerant itching-relieving action；Taking orally can
As carminative, for headache and nose；Pharynx；Laryngitis etc..
Borneolum Syntheticum, Borneolum Syntheticum are the crisp crystallization of the lamellar of water white transparency or white translucent；Gas delicate fragrance, it is acrid in the mouth, cool, GUIXIN, liver,
Lung meridian；Delicate fragrance a surname dissipate, with inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, effect of improving acuity of vision and removing nebula；Borneolum Syntheticum easily passes through blood brain barrier.Research table
Bright, Borneolum Syntheticum substantially can relax the intercellular zonula occludenss of blood brain barrier, so as to accelerate material intercellular to shift；It is a kind of effective transdermal
Accelerator, promotes drug absorption；Natural Broneolum Syntheticum can substantially suppress the mouse peritoneal capillary permeability that acetic acid causes to increase
Height, with antiinflammatory action；Thermostimulation can be obviously prolonged and cause mice pain reaction time and pain reaction, with analgesic activity；In vitro
Directly antivirus test is shown with the effect for suppressing influenza virus.
Lemon grass (Cymbopogon citratus) quintessence oil, lemon grass (Cymbopogon citratus) quintessence oil are a kind of quintessence oils for extracting from lemon grass (Cymbopogon citratus), have extraordinary anti-depression, antibacterial,
Sterilization, flatulence of dispelling, deodorization, help digest, diuresis, antifungal, lactogenic, kill insecticide, prevention disease, excitation, mend the work(such as body
Effect；Excitation, recovery, generation energy, it is helpful for used-up state, spirit is improved, is set out again；It is powerful, it is micro- sweet,
With NINGMENGXIANG taste.
Eucalyptus quintessence oil, has obvious effect, prevention bacteria breed and storage pus, promotes neoblastic construction to skin scald,
Improve suppuration, herpess, comedo skin, unimpeded pore；Incised wound, wound, ulcer and inflammation symptom, using equal after eucalyptus quintessence oil
Reaction is good；The effect of antiviral, it is most effective to respiratory tract disease, inflammation phenomenon can be relaxed, makes nasal mucosa comfortable；Refresh oneself awake
Brain, focuses on；Eucalyptus globoluss incense is used, with purify air, sterilization, the effect of anti-demodicid mite, sprinkling after dilute with water is stayed at home,
Can be with the flea with driving away mosquito and house pet.
Oil of Cymbopogon winterianus, oil of Cymbopogon winterianus are extracted from nardgrass plant (Cymbopogon nardus), belong to standing grain
Undergraduate course Cymbopogon.Although this quintessence oil is already identified a kind of anthelmintic quintessence oil (especially effective to carrying the mosquito of malaria).
It for pure and fresh brains, clean rooms, make dermalaxia also have very big benefit；Can be also used for cleaning oily skin and antiperspirant
Foot.The volatility of quintessence oil is very strong, once ingress of air will volatilize quickly, also based on this reason, quintessence oil must be used can be with close
The bottle storage of envelope, once corkage is used, also will cover back lid as early as possible.A few drop oil of Cymbopogon winterianus are instilled in the hot water of foot bath, can
To reach the purpose of promoting blood circulation meridians, moreover it is possible to reach the effect for removing tinea pedis foot odor.
Cetyl dimethyl amine oxide, this product zest are low, the anion zest that can be effectively reduced in detergent,
The features such as also there is sterilization, calcium soap dispersion, easily biological-degradable.Scourability is excellent, foaming abundancy and stablize, property gently stimulates
Property is low, with excellent antistatic behaviour and flexibility.
Anophelifuge antibacterial of the present invention is alkalescence, effectively neutralizes the formic acid of Formica fusca mosquito, while quickly killing after penetrating into skin
Dead bacterial viruses, Herba Menthae Borneolum Syntheticum is used as heat-clearing and toxic substances removing and penetrating agent, synergism；Various plants essential oil synergism are effectively kept away
Mosquito；Cetyl dimethyl amine oxide is cationic surfactant, (containing mosquito-repellent essential oil and can be resisted in object and skin surface
Microbial inoculum) protecting film is formed, extend anophelifuge time 4-6 hours, while having moisture-keeping function to skin；Effectively prevent dengue fever, malaria
Etc. the disease of mosquitoes spread, while there is good therapeutical effect to mosquito bite.
Specific embodiment
With reference to specific embodiment, the present invention is described in further detail, but does not constitute to any of the present invention
Limit.
Embodiment 1
Present embodiments provide a kind of anophelifuge antibacterial, including the raw material of following weight portion：0.1 part of antibacterial, Mentholum
0.5 part of solution, 0.05 part of Borneolum Syntheticum, 0.5 part of cetyl dimethyl amine oxide, 1 part of plant extract, and 20 parts of purified water,
Wherein, antibacterial is myristyl benzyl dimethyl ammonium chloride and DDAC complex, and its weight ratio is 3:
2；The Mentholum solution includes Mentholum and solubilizing agent, and wherein Mentholum, the weight ratio of solubilizing agent are 1: 3, and solubilizing agent is preferred
Oleum Ricini PEG-40；Plant extract includes lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) quintessence oil, You Jia
Sharp quintessence oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2；The pH value of obtained anophelifuge antibacterial is 7.5.
Anophelifuge antibacterial of the present invention can adopt the conventional method of this area to prepare completely, in the present invention anophelifuge antibacterial
Preparation method be prior art, not special character, the main improvement of the present invention are that the difference of formula.
Embodiment 2
Present embodiments provide a kind of anophelifuge antibacterial, including the raw material of following weight portion：0.15 part of antibacterial, Mentholum
0.75 part of solution, 0.075 part of Borneolum Syntheticum, 0.75 part of cetyl dimethyl amine oxide, 1.5 parts of plant extract, and purified water
25 parts, wherein, antibacterial is myristyl benzyl dimethyl ammonium chloride and DDAC complex, its weight ratio
For 3: 2；The Mentholum solution includes Mentholum and solubilizing agent, and wherein Mentholum, the weight ratio of solubilizing agent are 1: 3, solubilizing agent
It is preferred that Oleum Ricini PEG-40；Plant extract includes lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) quintessence oil,
Eucalyptus quintessence oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2；The pH value of obtained anophelifuge antibacterial is 7.6.
Embodiment 3
Present embodiments provide a kind of anophelifuge antibacterial, including the raw material of following weight portion：0.2 part of antibacterial, Mentholum
1 part of solution, 0.1 part of Borneolum Syntheticum, 1 part of cetyl dimethyl amine oxide, 2 parts of plant extract, and 30 parts of purified water, wherein,
Antibacterial is myristyl benzyl dimethyl ammonium chloride and DDAC complex, and its weight ratio is 3: 2；It is described
Mentholum solution includes Mentholum and solubilizing agent, and wherein Mentholum, the weight ratio of solubilizing agent are 1: 3, the preferred Oleum Ricini of solubilizing agent
PEG-40；Plant extract includes lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus globoluss essence
Oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2；The pH value of obtained anophelifuge antibacterial is 7.7.
Embodiment 4
Present embodiments provide a kind of anophelifuge antibacterial, including the raw material of following weight portion：0.25 part of antibacterial, Mentholum
1.25 parts of solution, 0.125 part of Borneolum Syntheticum, 1.25 parts of cetyl dimethyl amine oxide, 2.5 parts of plant extract, and purified water
35 parts, wherein, antibacterial is myristyl benzyl dimethyl ammonium chloride and DDAC complex, its weight ratio
For 3: 2；The Mentholum solution includes Mentholum and solubilizing agent, and wherein Mentholum, the weight ratio of solubilizing agent are 1: 3, solubilizing agent
It is preferred that Oleum Ricini PEG-40；Plant extract includes lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) quintessence oil,
Eucalyptus quintessence oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2；The pH value of obtained anophelifuge antibacterial is 7.8.
Embodiment 5
Present embodiments provide a kind of anophelifuge antibacterial, including the raw material of following weight portion：0.3 part of antibacterial, Mentholum
1.5 parts of solution, 0.15 part of Borneolum Syntheticum, 1.5 parts of cetyl dimethyl amine oxide, 3 parts of plant extract, and 40 parts of purified water,
Wherein, antibacterial is myristyl benzyl dimethyl ammonium chloride and DDAC complex, and its weight ratio is 3:
2；The Mentholum solution includes Mentholum and solubilizing agent, and wherein Mentholum, the weight ratio of solubilizing agent are 1: 3, and solubilizing agent is preferred
Oleum Ricini PEG-40；Plant extract includes lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) quintessence oil, You Jia
Sharp quintessence oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2；The pH value of obtained anophelifuge antibacterial is 7.9.
(1) repellent experiment
300 female mosquitos are put in the mosquito cage of 30cm × 30cm × 40cm.By the present embodiment 1-5 finished products and untreated fish group pair
Than.100 healthy volunteers are chosen, before age 15-60 year, men and women half and half, smears about in experimenter's the back of the hand
The test liquid of 0.12ml/cm2, then stretches into handss in mosquito cage, exposes 5min per hour, observes 6h, and records mosquito bite
Number of times.Test temperature 27-32 DEG C, humidity is 40-55%, dim light.Untreated staff bites average time for 27 times.Its
As a result it is as shown in table 1.
1 finished product repellent experimental data of table
| Bite number of times (secondary) | |
| Untreated fish group | 30 |
| Embodiment 1 | 12 |
| Embodiment 2 | 8 |
| Embodiment 3 | 6 |
| Embodiment 4 | 5 |
| Embodiment 5 | 13 |
(2) anti-microbial property test
With escherichia coli, staphylococcus aureus agent as strain, anti-microbial property survey is carried out to sample using concussion flask method
Examination, the anti-microbial property of sample are evaluated by bacteriostasis rate, and testing result is shown in Table 2.
The anti-microbial property test result of 2 finished products of table
From above-mentioned test, finished product of the present invention has significant anophelifuge, antibacterial action.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, technology according to the present invention scheme and its
Inventive concept equivalent or change in addition, should all be included within the scope of the present invention.
Claims (9)
1. a kind of anophelifuge antibacterial, it is characterised in that including the raw material of following weight portion：Antibacterial 0.1-0.3 parts, Mentholum are molten
Liquid 0.5-1.5 parts, plant extract 1-3 parts, and purified water 20-40 part.
2. a kind of anophelifuge antibacterial according to claim 1, it is characterised in that also including the raw material of following weight portion：Ice
Piece 0.05-0.15 parts.
3. a kind of anophelifuge antibacterial according to claim 1, it is characterised in that also including the raw material of following weight portion：Sun
Ionic surface active agent 0.5-1.5 parts.
4. a kind of anophelifuge antibacterial according to claim 1, it is characterised in that the antibacterial is dodecyldimethylamine base
Benzyl ammonium chloride and DDAC complex, its weight ratio are 3: 2.
5. a kind of anophelifuge antibacterial according to claim 1, it is characterised in that the Mentholum solution include Mentholum and
Solubilizing agent, wherein Mentholum, the weight ratio of solubilizing agent are 1: 3.
6. a kind of anophelifuge antibacterial according to claim 5, it is characterised in that the preferred Oleum Ricini PEG- of the solubilizing agent
40。
7. a kind of anophelifuge antibacterial according to claim 1, it is characterised in that the plant extract includes lemon grass (Cymbopogon citratus) essence
Oil, eucalyptus quintessence oil, oil of Cymbopogon winterianus, wherein lemon grass (Cymbopogon citratus) quintessence oil, eucalyptus quintessence oil, the weight ratio of oil of Cymbopogon winterianus are 1: 1: 2.
8. a kind of anophelifuge antibacterial according to claim 3, it is characterised in that the cationic surfactant preferably ten
Six alkyl dimethyl amine oxides.
9. a kind of anophelifuge antibacterial according to any one of claim 1-8, it is characterised in that described anophelifuge antibacterial
PH value is 7.5-7.9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710072864.8A CN106581498A (en) | 2017-02-10 | 2017-02-10 | Anti-mosquito antibacterial agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710072864.8A CN106581498A (en) | 2017-02-10 | 2017-02-10 | Anti-mosquito antibacterial agent |
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| CN106581498A true CN106581498A (en) | 2017-04-26 |
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ID=58586970
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| CN201710072864.8A Pending CN106581498A (en) | 2017-02-10 | 2017-02-10 | Anti-mosquito antibacterial agent |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107595656A (en) * | 2017-09-30 | 2018-01-19 | 李忠泽 | A kind of antiseptic for treating tinea pedis |
| CN107998132A (en) * | 2017-11-21 | 2018-05-08 | 洛阳师范学院 | A kind of quick-acting relieving itching and eliminating swelling agent and preparation method thereof that relieve the pain of bite by mosquitos |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860821A (en) * | 2014-03-11 | 2014-06-18 | 北京德默高科医药技术有限公司 | Broad-spectrum disinfectant composition |
| CN105380858A (en) * | 2015-12-04 | 2016-03-09 | 武汉璟泓万方堂医药科技股份有限公司 | Mosquito-repelling, bacterium-inhibiting, and itch-relieving spraying agent |
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2017
- 2017-02-10 CN CN201710072864.8A patent/CN106581498A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860821A (en) * | 2014-03-11 | 2014-06-18 | 北京德默高科医药技术有限公司 | Broad-spectrum disinfectant composition |
| CN105380858A (en) * | 2015-12-04 | 2016-03-09 | 武汉璟泓万方堂医药科技股份有限公司 | Mosquito-repelling, bacterium-inhibiting, and itch-relieving spraying agent |
Non-Patent Citations (1)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107595656A (en) * | 2017-09-30 | 2018-01-19 | 李忠泽 | A kind of antiseptic for treating tinea pedis |
| CN107998132A (en) * | 2017-11-21 | 2018-05-08 | 洛阳师范学院 | A kind of quick-acting relieving itching and eliminating swelling agent and preparation method thereof that relieve the pain of bite by mosquitos |
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