CN107595656A - A kind of antiseptic for treating tinea pedis - Google Patents
A kind of antiseptic for treating tinea pedis Download PDFInfo
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- CN107595656A CN107595656A CN201710913624.6A CN201710913624A CN107595656A CN 107595656 A CN107595656 A CN 107595656A CN 201710913624 A CN201710913624 A CN 201710913624A CN 107595656 A CN107595656 A CN 107595656A
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- antiseptic
- tinea pedis
- essential oil
- treating tinea
- oil
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Abstract
The invention discloses a kind of antiseptic for treating tinea pedis, including dodecyl benzyl dimethyl ammonium chloride 0.05%, DDAC 0.04%, dimethyl alkyl ammomium chloride 0.5%, peppermint extract solution 3.0%, borneol 2.0%, plants essential oil 2.0%, solubilizer 1.5% and surplus purified water.A kind of antiseptic for treating tinea pedis proposed by the present invention, using dodecyl benzyl dimethyl ammonium chloride and DDAC as main sterilising components, the sterilizing ability with broad-spectrum high efficacy；Also added three kinds of plants essential oils in addition includes deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus, has good therapeutic action to athlete's foot, additionally it is possible to improve the reparation repair ability of skin and mucosa, improve immunity of organisms；Peppermint, borneol be added to promote absorption of the skin to medicine, long duration of action is allowed medicament in skin, so as to improve anti-inflammation, repair the effect of skin.
Description
Technical field
The present invention relates to daily chemical product technical field, more particularly to a kind of antiseptic for treating tinea pedis and preparation method thereof.
Background technology
Skin and mucous membrane get up protecting human body, the external boundary of human body is formd a closed system, work as harmful substance
It is that extraneous pathogenic factor is stopped that skin and mucous membrane are human bodies in vitro by skin and mucous membrane first when will invade human body
Anti-infectious the first line of defence, thus it is more important to the disinfecting, antimicrobial of skin and mucosa.Pathogenic microorganisms common at present includes
Staphylococcus aureus, Escherichia coli, Candida albicans, propionibacterium acnes etc., it can cause the disease of various skins, mucous membrane
Disease.
Tinea pedis, be commonly called as tinea pedis, be a kind of pole common skin diseases, be mostly because fungal infection caused by, can be by a variety of
Route infection；Because the fungi of foot is not easy elimination and recurrent exerbation, athlete's foot often aggravates in summer, and winter mitigates, also someone
It is not cured throughout the year.Have at present it is a variety for the treatment of athlete's foots medicines, such as Da Kening, ZUGUANG SAN, these medicine generally existing slowly effects,
The defects of high recurrence rate, though there is certain therapeutic effect, it is not easy to eradicate, the effect of slight relief is can only achieve for the state of an illness,
Preferable effect is unable to reach, causes the pain that patient is permanent.
The content of the invention
Based on technical problem existing for background technology, the present invention, which proposes, provides a kind of antiseptic for treating tinea pedis, has
Good antibacterial effect and repair ability.
A kind of antiseptic for treating tinea pedis, including following component in parts by weight：Including in percentage by weight
Following component：Dodecyl benzyl dimethyl ammonium chloride 0.05-0.09%, DDAC 0.04-0.08%,
Dimethyl alkyl ammomium chloride 0.5-1.2%, plants essential oil 2.0-5.0%, solubilizer 1.5-2.5% and surplus purified water.
Preferably, the component of following percentage by weight meter is included：Peppermint extract solution 3.0-5.0%.
Preferably, the component of following percentage by weight meter is included：Borneol 2.0-3.5%.
Preferably, the solubilizer is that PEG-40 hydrogenates base castor oil.
Preferably, the plants essential oil includes deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus.
Preferably, the addition of the deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus is (6-8) in mass ratio：(3-5)：
1。
A kind of preparation method for the antiseptic for treating tinea pedis, method and step are as follows：S1：Dodecyl is added into purified water
Dimethyl benzyl ammonium chloride, DDAC and dimethyl alkyl ammomium chloride and borneol, are stirred at 208-212 DEG C
It is well mixed；S2：After solution is cooled to 30-40 DEG C made from S1, solubilizer, plants essential oil and the mixing of peppermint extract solution are added
Uniformly, produce.
Further, the mixing time of the S1 is 20-30min, and the mixing time of the S2 is 10-15min.
A kind of composition proposed by the present invention is applied to treatment tinea pedis, antibacterial skin etc..
Feature component：
Dodecyl benzyl dimethyl ammonium chloride is a kind of cationic surfactant, belongs to non oxidizing bactericide, has
Wide spectrum, efficient sterilization algae removal ability, bacterium algae breeding and foundry loam growth in water can be efficiently controlled, and be shelled with good foundry loam
From effect and certain scattered, osmosis, at the same have it is certain deoil, deodorizing capability and corrosion inhibition；Its small toxicity, nothing
Accumulation property toxicity, to skin without obvious stimulation and soluble in water.
DDAC is a kind of cationic surfactant, category double-chain quaternary ammonium salt class compound, under normal temperature
Stable for light yellow transparent liquid, soluble in water and organic solvent, chemical property, excitant is small；Insect disease can be controlled, is being cured
Medicine is hygienic and civilian etc. to be used as disinfectant and bactericide.
A kind of conventional efficient solubilizing agents of Cremophor RH40, can equably divide the oily matters such as essence, essential oil
It is scattered in water, forms the solution of stable transparent；Cremophor RH40 initiation material comes from natural plants -- hydrogenated castor
Oil, can be biodegradable in nature, is adapted to the industries such as agricultural chemicals, coating, daily use chemicals, water-based ink, weaving, printing and dyeing, papermaking.
Deodar essential oil is the volatile flavor extracted in the flower from deodar, leaf, stem, root or fruit, is had notable
Anti-inflammatory, antibacterial, convergence the effect of, can help to eliminate scab, purulence and some chronic diseases, such as eczema and chronic eczema；And have and dispel
Except the effect of tinea pedis foot odour.
Oil of Cymbopogon winterianus is usually used in clean rooms, pure and fresh brains, softening skin；It can be also used for cleaning Oily and sweat
Pin, thick to pore have certain effect, can adjust skin, removes acne, balance oily skin, in addition to tinea pedis and other moulds
Infection also has the effect of certain.
Chinese ilex essential oil has sterilization, diuresis, excitation, antirheumatic, the characteristic to stimulate circulation, can not only releive, in advance
Anti-rheumatism, muscle sprain, also there is the effect of good to tangerine hull constitution and pock skin；Simultaneously can asking with tinea pedis foot odour
Topic.
Peppermint has the effect of refrigerant, antipruritic, anti-inflammatory, analgesic；Menthol can stimulate cutaneous nerve tip receptor, first
Cool sensation is produced, then there is slight burning heat sensation, slowly in saturating fell, prolonged hyperemia can be caused, and reaches treatment
Effect.
Borneol is clinical conventional Chinese medicine, and the traditional Chinese medical science takes the effect of its consciousness regaining, clearing away heat to and alleviating pain, erosion prevention and muscle growing more, modern
Pharmacological research shows that borneol has a variety of medicinal efficacies；Borneol is a kind of effective transdermal enhancer, can promote skin to medicine
Absorption, antibacterial, anti-inflammatory, analgesic activity, in addition borneol can increase granulation tissue structure and reepithelialization, it is attached to repair skin
Belong to organ and there is stronger Wound Healing.
Application method：It can be directly used for foot's skin, it can also be used to other skin surfaces.
Points for attention：It must not be used in mixed way with soap, anion surfactant
Compared with prior art, the device have the advantages that being：
A kind of antiseptic for treating tinea pedis proposed by the present invention, with dodecyl benzyl dimethyl ammonium chloride and didecyl two
Ammonio methacrylate is as main sterilising components, the sterilizing ability with broad-spectrum high efficacy；Three kinds of plants essential oil bags are also added in addition
Deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus are included, there is good therapeutic action to athlete's foot, additionally it is possible to improves repairing for skin and mucosa
Reactivation power, improves immunity of organisms；Peppermint, borneol be added to promote absorption of the skin to medicine, allow medicament to
Long duration of action is in skin, so as to improve anti-inflammation, repair the effect of skin.
It the experiment proved that, antiseptic produced by the present invention has no side effect safely, to by Escherichia coli, Candida albicans, gold
Staphylococcus aureus have significant killing action, and the effective percentage for treating tinea pedis is 96.1%.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment 1
A kind of antiseptic for treating tinea pedis, including following component in parts by weight：Dodecyl dimethyl benzyl chloride
Change ammonium 0.05%, DDAC 0.04%, dimethyl alkyl ammomium chloride 0.5%, peppermint extract solution 3.0%, ice
Piece 2.0%, plants essential oil 2.0%, solubilizer 1.5% and surplus purified water.
The addition of deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus is 6 in mass ratio in plants essential oil：3：1.
A kind of preparation method for the antiseptic for treating tinea pedis, method and step are as follows：
S1：Dodecyl benzyl dimethyl ammonium chloride, DDAC and dimethyl are added into purified water
Alkyl ammomium chloride and borneol, it is uniformly mixed at 208 DEG C, mixing time 30min；
S2：After solution made from S1 is cooled to 30 DEG C, it is equal to add solubilizer, plants essential oil and the mixing of peppermint extract solution
It is even, mixing time 15min, produce.
Embodiment 2
A kind of antiseptic for treating tinea pedis, including following component in parts by weight：Dodecyl dimethyl benzyl chloride
Change ammonium 0.09%, DDAC 0.08%, dimethyl alkyl ammomium chloride 1.2%, peppermint extract solution 5.0%, ice
Piece 3.5%, plants essential oil 5.0%, solubilizer 2.5% and surplus purified water.
The addition of deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus is 6 in mass ratio in plants essential oil：5：1.
A kind of preparation method for the antiseptic for treating tinea pedis, method and step are as follows：
S1：Dodecyl benzyl dimethyl ammonium chloride, DDAC and dimethyl are added into purified water
Alkyl ammomium chloride and borneol, it is uniformly mixed at 212 DEG C, mixing time 20min；
S2：After solution made from S1 is cooled to 40 DEG C, it is equal to add solubilizer, plants essential oil and the mixing of peppermint extract solution
It is even, mixing time 10min, produce.
Embodiment 3
A kind of antiseptic for treating tinea pedis, including following component in parts by weight：Dodecyl dimethyl benzyl chloride
Change ammonium 0.07%, DDAC 0.06%, dimethyl alkyl ammomium chloride 0.9%, peppermint extract solution 4.0%, ice
Piece 2.7%, plants essential oil 3.5%, solubilizer 2.0% and surplus purified water.
The addition of deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus is 7 in mass ratio in plants essential oil：4：1.
A kind of preparation method for the antiseptic for treating tinea pedis, method and step are as follows：
S1：Dodecyl benzyl dimethyl ammonium chloride, DDAC and dimethyl are added into purified water
Alkyl ammomium chloride and borneol, it is uniformly mixed at 210 DEG C, mixing time 25min；
S2：After solution made from S1 is cooled to 35 DEG C, it is equal to add solubilizer, plants essential oil and the mixing of peppermint extract solution
It is even, mixing time 12min, produce.
Embodiment 4
A kind of antiseptic for treating tinea pedis, including following component in parts by weight：Dodecyl dimethyl benzyl chloride
Change ammonium 0.06%, DDAC 0.05%, dimethyl alkyl ammomium chloride 0.7%, peppermint extract solution 3.5%, ice
Piece 2.3%, plants essential oil 2.8%, solubilizer 2.2% and surplus purified water.
The addition of deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus is 6 in mass ratio in plants essential oil：5：1.
A kind of preparation method for the antiseptic for treating tinea pedis, method and step are as follows：
S1：Dodecyl benzyl dimethyl ammonium chloride, DDAC and dimethyl are added into purified water
Alkyl ammomium chloride and borneol, it is uniformly mixed at 209 DEG C, mixing time 27min；
S2：After solution made from S1 is cooled to 32 DEG C, it is equal to add solubilizer, plants essential oil and the mixing of peppermint extract solution
It is even, mixing time 11min, produce.
Embodiment 5
A kind of antiseptic for treating tinea pedis, including following component in parts by weight：Dodecyl dimethyl benzyl chloride
Change ammonium 0.08%, DDAC 0.07%, dimethyl alkyl ammomium chloride 1.1%, peppermint extract solution 4.5%, ice
Piece 3.2%, plants essential oil 4.5%, solubilizer 1.7% and surplus purified water.
The addition of deodar essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus is 8 in mass ratio in plants essential oil：3：1.
A kind of preparation method for the antiseptic for treating tinea pedis, method and step are as follows：
S1：Dodecyl benzyl dimethyl ammonium chloride, DDAC and dimethyl are added into purified water
Alkyl ammomium chloride and borneol, it is uniformly mixed at 211 DEG C, mixing time 27min；
S2：After solution made from S1 is cooled to 38 DEG C, it is equal to add solubilizer, plants essential oil and the mixing of peppermint extract solution
It is even, mixing time 13min, produce.
Properties of product detect
First, skin irritation test
1st, subjects：2.8-3.2kg healthy rabbits 50 are chosen, every rabbit back selects shaving 3cm at 42。
2nd, test method：The antiseptic implemented obtained by 1-5 is smeared in tested material, each embodiment is applied to 10 rabbits；
Film once, is observed and records the dermoreaction after 24h, 48h, 72h for every eight hours.
3rd, result of the test：Found after 24h, 48h, 72h observation, 50 tested rabbit do not occur rubefaction, hair
The local excitations such as rash are reacted, and illustrate that antiseptic produced by the present invention is safe and non-stimulating, adverse reaction will not be produced to skin.
2nd, sterile test
1st, Suspension quantitative bactericidal test：Reference《Disposable Sanitary Accessory health mark》GB 15979-2002 appendix Cs
And《Disinfection technology standard》(version in 2002) (defending method prison hair [2002] 282) 2.1.11.3 is tested.It is made with embodiment 3
Sample stoste, action time 1min, 2min, 5min, 10min, experiment is repeated 3 times, and test temperature is 20-21 DEG C.
2nd, result of the test：It is shown in Table 1.
Table 1 sterilizes result
Conclusion：Antiseptic produced by the present invention acts on 1min to Escherichia coli, Candida albicans, staphylococcus aureus,
Sterilization rate is 100%；Illustrate that the antiseptic is rapid-action, bactericidal effect is good.
3rd, clinical test
1st, subjects：260 patients, age 23-60 year, tinea pedis is all suffered from, tinea pedis type includes vesicle, erosion
Type, scales of skin that peel off keratinization type or mixed type.
2nd, treatment method：Using the principle of parallel control, 260 patients are divided into treatment group and control group, treatment group 180
People, the people of control group 80.Through statistical analysis, two groups of patient ages, the course of disease there was no significant difference (P>0.05), there is comparativity.
Treatment group：Antiseptic produced by the present invention is smeared in affected part, 3 times a day, 7 days are 1 course for the treatment of, treat 3 courses for the treatment of.
Control group：Da Kening is smeared in affected part, 3 times a day, 37 days are 1 course for the treatment of, treat 3 courses for the treatment of.
3rd, criterion：
It is effective：Red and swollen, rotten to the corn, decortication, pruritis disappear, and skin recovers bright and clean smooth；
Effectively：Disease makes moderate progress before compared with use, symptom mitigation；
It is invalid：Symptom without improvement or aggravates.
4th, result on trial：It is shown in Table 2.
The clinic trial result of table 2
| Group | Number | It is effective | Effectively | It is invalid | It is efficient |
| Treatment group | 180 | 95 | 78 | 7 | 96.1% |
| Control group | 80 | 15 | 52 | 13 | 83.8% |
Conclusion：Being found through clinical test, antiseptic produced by the present invention is 96.1% for the treated effect of tinea pedis, compared with
Control group is compared, and effective percentage significantly improves.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (9)
1. a kind of antiseptic for treating tinea pedis, it is characterised in that including following component in percentage by weight：Dodecyl
Dimethyl benzyl ammonium chloride 0.05-0.09%, DDAC 0.04-0.08%, dimethyl alkyl ammomium chloride 0.5-
1.2%th, plants essential oil 2.0-5.0%, solubilizer 1.5-2.5% and surplus purified water.
2. a kind of antiseptic for treating tinea pedis according to claim 1, it is characterised in that also including following percentage by weight
The component of meter：Peppermint extract solution 3.0-5.0%.
3. a kind of antiseptic for treating tinea pedis according to claim 1, it is characterised in that also including following percentage by weight
The component of meter：Borneol 2.0-3.5%.
4. a kind of antiseptic for treating tinea pedis according to claim 1, it is characterised in that the solubilizer is PEG-40 hydrogen
Change base castor oil.
5. a kind of antiseptic for treating tinea pedis according to claim 1, it is characterised in that the plants essential oil includes deodar
Essential oil, Chinese ilex essential oil and oil of Cymbopogon winterianus.
6. a kind of antiseptic for treating tinea pedis according to claim 5, it is characterised in that the deodar essential oil, Chinese ilex essence
Oil and the addition of oil of Cymbopogon winterianus are in mass ratio（6-8）：（3-5）：1.
A kind of 7. preparation method of antiseptic for treating tinea pedis according to claim any one of 1-6, it is characterised in that side
Method step is as follows：S1：Dodecyl benzyl dimethyl ammonium chloride, DDAC and diformazan are added into purified water
Base alkyl ammomium chloride and borneol, it is uniformly mixed at 208-212 DEG C；S2：Treat that solution is cooled to 30-40 DEG C made from S1
Afterwards, solubilizer, plants essential oil and peppermint extract solution are added to be well mixed, produced.
8. the preparation method of a kind of antiseptic for treating tinea pedis according to claim 7, it is characterised in that the S1's stirs
It is 20-30min to mix the time, and the mixing time of the S2 is 10-15min.
9. the composition described in claim any one of 1-6 is applied to treatment tinea pedis, antibacterial skin etc..
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Citations (1)
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| CN106581498A (en) * | 2017-02-10 | 2017-04-26 | 李忠泽 | Anti-mosquito antibacterial agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581498A (en) * | 2017-02-10 | 2017-04-26 | 李忠泽 | Anti-mosquito antibacterial agent |
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Application publication date: 20180119 |
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