CN105028452A - Air disinfecting spray solution and preparation method of same - Google Patents
Air disinfecting spray solution and preparation method of same Download PDFInfo
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- CN105028452A CN105028452A CN201510253668.1A CN201510253668A CN105028452A CN 105028452 A CN105028452 A CN 105028452A CN 201510253668 A CN201510253668 A CN 201510253668A CN 105028452 A CN105028452 A CN 105028452A
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Abstract
The invention aims to provide an air disinfecting spray solution used in room and car and a preparation method thereof. The air disinfecting spray solution is prepared from polyhexamethylene guanidine hydrochloride, ethanol, polyacrylic acid, fatty alcohol-polyoxyethylene ether, borneol, mint and purified water. The air disinfecting spray solution is suitable for disinfection in room and cars and on surfaces of objects. The invention provides an air and object-surface disinfecting product, which is broader in spectrum and is safe and effective to use, for family houses, office rooms, classrooms, clinic rooms, wards and the like.
Description
Technical field
The present invention relates to pharmaceutical technology sectors, provide especially in a kind of indoor, car with air sterillization spray liquid and preparation method thereof.
Background technology
Along with the development mankind of society more and more pursue healthy lifestyles, but the life style of modern civilization and the mankind brings up influenza virus, bacterium dust virus in pharyngitis, rhinitis, air, in order to the bad pollutant in settle air, improve indoor, air pollution, in indoor, car, air-atomizing disinfectant and atomization plant special-purpose sprayer thereof arise at the historic moment.
Summary of the invention
The object of the present invention is to provide that a kind of Disinfection Effect is good, nontoxic, colourless, the air-atomizing thimerosal of non-corrosiveness, non-environmental-pollution and preparation method thereof.
Air sterillization spray liquid of the present invention, the weight proportion of its medicine material is:
Most preferably proportioning is:
Present invention also offers the preparation method of described air sterillization spray liquid, it is characterized in that, concrete steps are as follows:
1), get 10kg purified water and be heated to 70 ~ 80 DEG C;
2), Polyhaxemethylenguanidine Hydrochloride is added in above-mentioned purified water make solution;
3), get 10kg ethanol dissolving borneol, then dilute it with 11kg ethanol;
4), get 10kg ethanol dissolving peppermint, then dilute it with 11kg ethanol;
5), get 10kg ethanol dissolving polyacrylic acid, then dilute it with 11kg ethanol;
6), getting 60kg purified water is heated to 50 ~ 80 DEG C, dissolved fat alcohol APEO;
7), Polyhaxemethylenguanidine Hydrochloride solution is added in fatty alcohol-polyoxyethylene ether solution;
8), when solution temperature is down to 40 DEG C add borneol solution, and keep solution temperature;
9), peppermint solution is added when keeping solution temperature 40 DEG C;
10), polyacrylic acid solution is added when keeping solution temperature 40 DEG C;
11), by the purified water of remainder inject in Polyhaxemethylenguanidine Hydrochloride solution, after stirring, leave standstill 24 hours;
12), solution is observed, clear and bright without suspension free from admixture, obtain air sterillization spray liquid.
Air-atomizing thimerosal formula side of the present invention separates:
1), Polyhaxemethylenguanidine Hydrochloride: the principle active component being this product, Escherichia coli, staphylococcus aureus, staphylococcus albus can be killed." hospital disinfection technical specification " the 2nd chapter hospital commonly use method for disinfection and sterilization record, air sterillization: with the Polyhaxemethylenguanidine Hydrochloride solution of 0.5%, spraying disinfection room air, consumption is 10ml/m
3, effect 60min.According to field trial conclusion, natural bacteria extinction rate meets the Ministry of Public Health's " disinfection technology standard " requirement.
2), ethanol: the secondary active ingredient being this product, has synergic remove with Polyhaxemethylenguanidine Hydrochloride compatibility, and its compound preparation strengthens than Polyhaxemethylenguanidine Hydrochloride single preparations of ephedrine bactericidal effect.
3), borneol: gas delicate fragrance, taste is pungent, cool." Tang Mucao " cloud: " its delicate fragrance is that hundred medicines are first, fragrant unequalled person in all things on earth ".Main Function is the smell regulating disinfectant, refrigerant spine, and micro-band medicine perfume, the banksia rose, pepper perfume, fragrance is elegant.
4), peppermint: taste is pungent, cool in nature, and smell delicate fragrance is dispersed.Main Function is the smell regulating disinfectant.
5), polyacrylic acid: activator, helps the thimerosal active ingredient molecule after spraying to be well atomized disperse in atmosphere.
6), fatty alcohol-polyoxyethylene ether: emulsifier, carrying principle active component and melting mutually and emulsifying soln between secondary active ingredient and adjunct ingredient, strengthen the aerial activity of disinfectant and atomizing effect.
Air-atomizing thimerosal of the present invention is applicable to air sterillization and surface disinfection in indoor, car.For family room, office, classroom, hospital outpatient, ward etc. provide more wide spectrum, safe and effective air sanitizer.
Staphylococcus aureus, Escherichia coli, staphylococcus albus are gone out test situation:
1, Escherichia coli sterilize experiment:
Air-atomizing disinfectant 1: 9 dilution, with containing 5% Tween-80,3% lecithin, 1% Chinese honey locust, 1% glycine TPS solution in and meter, can effectively in and phage surface residual disinfectancy liquid to colibacillary effect, and neutralizer and neutralized reaction product are cultivated test Escherichia coli and convalescence thereof and are had no significant effect.
Air-atomizing disinfectant 1: 9 dilution is 4.72 to the average kill oncomelania of Escherichia coli effect 5min, and effect 10min, 15min, average kill oncomelania is all greater than 5.00.
2, staphylococcus aureus sterilize experiment:
Air-atomizing disinfectant 1: 9 dilution is to staphylococcus aureus effect 5min, 10min, 15min, and average kill oncomelania is all greater than 5.00.
3, staphylococcus albus:
Air-atomizing thimerosal 1: 9 dilution, with containing 5% Tween-80,3% lecithin, 1% Chinese honey locust, 1% glycine TPS solution in and meter, can effectively in and phage surface residual disinfectancy liquid to the staphylococcic effect of white, and neutralizer and neutralized reaction product are cultivated test staphylococcus albus and convalescence thereof and are had no significant effect.
Air-atomizing thimerosal stoste, dosage is 10ml/m
3, effect 60min, when average Natural Decline rate is 59.48%, to 20m
3in aerosol cabinet air, staphylococcus albus average kill ratio reaches 99.95%.
4, air-atomizing thimerosal 1: 9 dilution, to body surface natural bacteria effect 10min, average kill oncomelania is 1.53.
5, air-atomizing thimerosal stoste, dosage is 10ml/m
3, to air natural bacterium effect 60min, average extinction rate is 98.85%.
6, field trial
Air sterilization effect qualification field trial, test ambient temperature is 20 DEG C, and the common Protective isolation of relative moisture 45% is indoor, and air-atomizing thimerosal, dosage is 10ml/m
3, to natural bacteria effect 60min, average extinction rate is 98.85%.
The toxicological security situation of each component in air-atomizing thimerosal formula of the present invention:
1, Polyhaxemethylenguanidine Hydrochloride:
Be high molecular polymer, so not easily absorbed by animal body inner tissue, greatly reduce its toxicity, make it to the cell of higher organism substantially without impact.
Experimental result according to Russian quarantine departments: Polyhaxemethylenguanidine Hydrochloride is 25000mg/kg for the median lethal dose LD50 of muroid, and for the LD50 of guinea pig up to 35000mg/kg.
" hospital disinfection technical specification ": Polyhaxemethylenguanidine Hydrochloride is 25000mg/kg for the median lethal dose LD50 of little muroid, for the LD50 of cavy up to 35000mg/kg; The Polyhaxemethylenguanidine Hydrochloride mouse stomach LD50 > 20900mg/kg of 2%.Be illustrated as actual nontoxic level.
2, ethanol:
Adopt edible alcohol standard in this product, be organic solvent good in formula, and have stronger osmosis, thimerosal is dissolved in ethanol, and bactericidal action strengthens, little to human body excitant, nontoxic, harmless to article.
3, borneol:
This product is the crisp crystallization of sheet of water white transparency or white translucent; Its effect in thimerosal regulates smell.To the research of borneol toxicity and safety, the LD50 of borneol gavage mouse is 1059mg/kg.Palant etc. then report that the Mouse oral LD50 of borneol, isoborneol, racemic modification is respectively 4960mg/kg, 3720mg/kg and 3830mg/kg.Jiang Guangchi etc. investigated borneol, isoborneol, synthetic borneol Mouse oral LD50 be respectively 2879mg/kg, 2269mg/kg and 2507mg/kg.Borneol toxicity is less, and isoborneol is slightly large, and synthetic borneol is mediate.Have different between each experimental result, but toxicity size sequence between borneol, isoborneol, synthetic borneol is consistent.
4, peppermint: taste is pungent, cool in nature." detailed outline " is recorded: " peppermint, pungently can disperse, cool can be sharp clearly, specially in Xiaofeng San heat.Therefore headache, head wind, eyes, throat, all diseases of ability to speak, children's's fever (of children) accompanied by fear and scrofula, sore scabies are key medicine.To the test of peppermint toxicity and safety, the LD of gavage mouse
50for 1059mg/kg.Real genus is nontoxic.
5, polyacrylic acid:
This product has spread effect to eye and skin.But to human body without acute toxicity.The concentration of rat oral LD505000m/kg, water flea LC is greater than 1000mg/L and belongs to low toxicity.In addition, the determination data of BOD BOD and chemical oxygen demand cod also shows that polyacrylic acid is innocuous substance.
6, fatty alcohol-polyoxyethylene ether:
Natural fatty alcohol and ethylene oxide synthesis thing, cotton-shaped liquid or white lotion, nontoxic, non-stimulated, having good emulsibility, dispersiveness, water-soluble, is important non-ionic surface active agent.According to the survey data that Environmental Protection Agency (EPA) provides, removing does not have to be degraded to carbonic acid gas and water by high biological, and it accumulates and the harm of formation to environment hardly in water and in sediments.
The toxicological security test of air-atomizing thimerosal of the present invention
1) test method is according to the Ministry of Public Health's " disinfection technology standard " version in 2002.
2) experimental result:
(1), acute oral toxicity test: the test of sterilization spray chmice acute per os, male and female chmice acute per os median lethal dose LD
50> 5000mg/kgBW is the nontoxic level of reality;
(2), acute inhalation toxicity test: the test of sterilization spray Acute inhalation, male and female chmice acute sucks median lethal concentration LC
502h > 10000mg/m
3, be the nontoxic level of reality;
(3), acute eye irritation test: sterilization spray acute eye irritation test, sterilization spray to the average score that Rabbits with Acute Eye irritation reacts 3 rabbit is: the infringement of corneal injury < 1, iris < 1, conjunctival congestion < 2 and chemosis < 2, be classified as nonirritant to the reaction of Rabbits with Acute Eye irritation.
(4), mice bone marrow micronucleus: sterilization spray mouse marrow cell micro nuclear test, sterilization spray to PCEMNR without causing micronucleus effect.
Air-atomizing thimerosal of the present invention take Polyhaxemethylenguanidine Hydrochloride as principle active component, avirulence, pollution-free, degradable, is feature of environmental protection air sterillization product of new generation; Because Polyhaxemethylenguanidine Hydrochloride is high molecular polymer, so not easily absorbed by animal body inner tissue, greatly reduce its toxicity, it is made to possess the cell of higher organism substantially without impact, and to the non-corrosive effect of various material, non-corrosiveness, degradable, the advantages such as environmentally safe are the representative products of hommization; Stronger killing and inhibitory action is had to bacterium and virus, sterilization mechanism is used to be that physics adds chemistry in conjunction with air sterillization sprayer, broad-spectrum, potent, continue antibacterial, result of the test shows that air sterillization spray liquid of the present invention uses natural bacteria extinction rate 98.85% in conjunction with dynalysor, and staphylococcus albus killing rate reaches 99.95%.Because active ingredient itself has no side effect, have no irritating odor, be more suitable for disinfection of indoor air and surface disinfection.
Embodiment
The preparation method of the embodiment of the present invention is:
1), get 10kg purified water and be heated to 70 ~ 80 DEG C;
2), Polyhaxemethylenguanidine Hydrochloride is added in above-mentioned purified water make solution;
3), get 10kg ethanol dissolving borneol, then dilute it with 11kg ethanol;
4), get 10kg ethanol dissolving peppermint, then dilute it with 11kg ethanol;
5), get 10kg ethanol dissolving polyacrylic acid, then dilute it with 11kg ethanol;
6), getting 60kg purified water is heated to 50 ~ 80 DEG C, dissolved fat alcohol APEO;
7), Polyhaxemethylenguanidine Hydrochloride solution is added in fatty alcohol-polyoxyethylene ether solution;
8), when solution temperature is down to 40 DEG C add borneol solution, and keep solution temperature;
9), peppermint solution is added when keeping solution temperature 40 DEG C;
10), polyacrylic acid solution is added when keeping solution temperature 40 DEG C;
11), by the purified water of remainder inject in Polyhaxemethylenguanidine Hydrochloride solution, after stirring, leave standstill 24 hours;
12), solution is observed, clear and bright without suspension free from admixture, obtain air sterillization spray liquid.
Embodiment 1
The weight proportion of air-atomizing thimerosal medicine material is:
Embodiment 2
The weight proportion of air-atomizing thimerosal medicine material is:
Embodiment 3
The weight proportion of air-atomizing thimerosal medicine material is:
Above-described embodiment, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.All equivalences done according to Spirit Essence of the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (3)
1. an air sterillization spray liquid, is characterized in that, the weight proportion of medicine material is:
2. according to air sterillization spray liquid described in claim 1, it is characterized in that, the weight proportion of medicine material is:
3., according to a preparation method for air sterillization spray liquid described in claim 1, it is characterized in that, concrete steps are as follows:
1), get 10kg purified water and be heated to 70 ~ 80 DEG C;
2), Polyhaxemethylenguanidine Hydrochloride is added in above-mentioned purified water make solution;
3), get 10kg ethanol dissolving borneol, then dilute it with 11kg ethanol;
4), get 10kg ethanol dissolving peppermint, then dilute it with 11kg ethanol;
5), get 10kg ethanol dissolving polyacrylic acid, then dilute it with 11kg ethanol;
6), getting 60kg purified water is heated to 50 ~ 80 DEG C, dissolved fat alcohol APEO;
7), Polyhaxemethylenguanidine Hydrochloride solution is added in fatty alcohol-polyoxyethylene ether solution;
8), when solution temperature is down to 40 DEG C add borneol solution, and keep solution temperature;
9), peppermint solution is added when keeping solution temperature 40 DEG C;
10), polyacrylic acid solution is added when keeping solution temperature 40 DEG C;
11), by the purified water of remainder inject in Polyhaxemethylenguanidine Hydrochloride solution, after stirring, leave standstill 24 hours;
12), solution is observed, clear and bright without suspension free from admixture, obtain air sterillization spray liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510253668.1A CN105028452A (en) | 2015-05-19 | 2015-05-19 | Air disinfecting spray solution and preparation method of same |
Applications Claiming Priority (1)
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|---|---|---|---|
| CN201510253668.1A CN105028452A (en) | 2015-05-19 | 2015-05-19 | Air disinfecting spray solution and preparation method of same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214926A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪（厦门）生物科技有限公司 | A kind of nasal spray and preparation method thereof |
| CN106689126A (en) * | 2016-12-14 | 2017-05-24 | 广州泰晟生物科技有限公司 | Polyhexamethylene guanidine effervescent preparation and preparing method thereof |
| CN108042562A (en) * | 2017-12-22 | 2018-05-18 | 北京长江脉医药科技有限责任公司 | Disposable disinfectant of the compound alcohol of gel-type and preparation method thereof |
| CN110506764A (en) * | 2019-09-29 | 2019-11-29 | 青岛动保国家工程技术研究中心有限公司 | A kind of farm disinfecting, deodorizing nanoemulsion and preparation method and application |
| CN111248228A (en) * | 2020-03-06 | 2020-06-09 | 吉林云飞医药有限公司 | Disinfectant for baby products and preparation method thereof |
| CN113994962A (en) * | 2021-11-01 | 2022-02-01 | 中科量子科技应用(广州)有限公司 | Disinfectant capable of atomizing, disinfecting and sterilizing and production method and use method thereof |
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| JPH05209195A (en) * | 1992-01-29 | 1993-08-20 | Olympus Optical Co Ltd | Detergent composition |
| CN1357235A (en) * | 2000-12-08 | 2002-07-10 | 马渝强 | Polyoxy alkene guanidine disinfectant |
| CN1478397A (en) * | 2003-07-03 | 2004-03-03 | 惠州兆婷化妆品有限公司 | Formulatioin of disinfecting liquid |
| CN101292653A (en) * | 2007-04-27 | 2008-10-29 | 上海利康消毒高科技有限公司 | Compound hexamethylene tetramine disinfectant liquid and its preparation |
| CN103110972A (en) * | 2011-11-17 | 2013-05-22 | 王晓薇 | Natural-fragrance air sterilization freshener |
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2015
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05209195A (en) * | 1992-01-29 | 1993-08-20 | Olympus Optical Co Ltd | Detergent composition |
| CN1357235A (en) * | 2000-12-08 | 2002-07-10 | 马渝强 | Polyoxy alkene guanidine disinfectant |
| CN1478397A (en) * | 2003-07-03 | 2004-03-03 | 惠州兆婷化妆品有限公司 | Formulatioin of disinfecting liquid |
| CN101292653A (en) * | 2007-04-27 | 2008-10-29 | 上海利康消毒高科技有限公司 | Compound hexamethylene tetramine disinfectant liquid and its preparation |
| CN103110972A (en) * | 2011-11-17 | 2013-05-22 | 王晓薇 | Natural-fragrance air sterilization freshener |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214926A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪（厦门）生物科技有限公司 | A kind of nasal spray and preparation method thereof |
| CN106689126A (en) * | 2016-12-14 | 2017-05-24 | 广州泰晟生物科技有限公司 | Polyhexamethylene guanidine effervescent preparation and preparing method thereof |
| CN108042562A (en) * | 2017-12-22 | 2018-05-18 | 北京长江脉医药科技有限责任公司 | Disposable disinfectant of the compound alcohol of gel-type and preparation method thereof |
| CN110506764A (en) * | 2019-09-29 | 2019-11-29 | 青岛动保国家工程技术研究中心有限公司 | A kind of farm disinfecting, deodorizing nanoemulsion and preparation method and application |
| CN111248228A (en) * | 2020-03-06 | 2020-06-09 | 吉林云飞医药有限公司 | Disinfectant for baby products and preparation method thereof |
| CN113994962A (en) * | 2021-11-01 | 2022-02-01 | 中科量子科技应用(广州)有限公司 | Disinfectant capable of atomizing, disinfecting and sterilizing and production method and use method thereof |
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