CN111481489A - Ligusticum wallichii extract with mosquito repelling and itching relieving effects and application thereof - Google Patents
Ligusticum wallichii extract with mosquito repelling and itching relieving effects and application thereof Download PDFInfo
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- CN111481489A CN111481489A CN202010432483.8A CN202010432483A CN111481489A CN 111481489 A CN111481489 A CN 111481489A CN 202010432483 A CN202010432483 A CN 202010432483A CN 111481489 A CN111481489 A CN 111481489A
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- 241000112528 Ligusticum striatum Species 0.000 title claims abstract description 35
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 34
- 230000007803 itching Effects 0.000 title claims abstract description 22
- 241000255925 Diptera Species 0.000 title claims abstract description 21
- 230000001846 repelling effect Effects 0.000 title claims abstract description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 57
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 26
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 19
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- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 19
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000005844 Thymol Substances 0.000 claims abstract description 19
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 239000000341 volatile oil Substances 0.000 claims description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000047 product Substances 0.000 claims description 18
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- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 12
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 12
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- 239000003814 drug Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000000077 insect repellent Substances 0.000 claims description 9
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 8
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- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 7
- 229940116229 borneol Drugs 0.000 claims description 7
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 7
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- 238000000034 method Methods 0.000 claims description 6
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- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
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- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses application of ligusticum wallichii and an extract thereof in preparing an external preparation with mosquito repelling and itching relieving effects, and also discloses a mosquito repelling and itching relieving composition, which is prepared from the following raw materials in parts by weight: 10-20 parts of ethyl butyl levulinate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-20 parts of ligusticum wallichii extract, 5-10 parts of citronella extract and 0.1-1 part of thymol. The invention also provides a preparation method of the pharmaceutical composition. The invention has the obvious effects of repelling mosquitoes, relieving itching and relieving itching.
Description
Technical Field
The invention particularly relates to a ligusticum wallichii extract with mosquito repelling and itching relieving effects and application thereof.
Background
Mosquitoes are the transmission vectors of severe infectious diseases such as malaria, epidemic encephalitis B, dengue fever, yellow fever and the like, and the mosquitoes can cause uncomfortable symptoms such as pruritus, gall, dermatitis and the like after blood sucking, thereby seriously harming human health. In order to reduce the harm of mosquitoes and the like, various mosquito-repelling and itching-relieving products become necessary sanitary products for people in summer, and mainly comprise floral water, essential oil, herbal oil and the like. With the continuous expansion of the use population of mosquito-repellent and itching-relieving products, the safety of the products is widely concerned, and particularly, the application of chemical repellents such as deet causes certain toxic and side effects to people, especially pregnant women and children.
In Chinese pharmacopoeia (2010 version), 151 finished preparations contain ligusticum wallichii accounting for 9.21% of the total 1640 Chinese patent medicines, the traditional Chinese medicine ligusticum wallichii is derived from dried rhizomes of L igustric chuanxinong Hort of Umbelliferae, and the extract of the ligusticum wallichii has the effects of activating blood and promoting qi circulation, and dispelling wind and relieving pain.
At present, no report about the mosquito repelling and itching relieving effects of the ligusticum wallichii extract exists, and a mosquito repelling and itching relieving skin care product which takes the ligusticum wallichii extract as an active ingredient, is obvious in effect and safe to use is also absent in the market.
Disclosure of Invention
In order to solve the problems, the invention provides the application of the ligusticum wallichii and the extract thereof in preparing the external preparation with the effects of repelling mosquitoes and relieving itching.
Further, the ligusticum wallichii extract is ligusticum wallichii essential oil.
Further, the essential oil of chuanxiong rhizome is an extract of chuanxiong rhizome prepared by supercritical carbon dioxide extraction.
The invention also provides a mosquito-repellent itching-relieving composition which is prepared from the following raw materials in parts by weight:
10-20 parts of ethyl butyl levulinate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-20 parts of ligusticum wallichii extract, 5-10 parts of citronella extract and 0.1-1 part of thymol.
Further, the feed additive is prepared from the following raw materials in parts by weight:
10 parts of ethyl butyl levulinate, 1 part of menthol, 1 part of menthone glycerol ketal, 10 parts of ligusticum wallichii extract, 10 parts of citronella extract and 1 part of thymol.
Further, the ligusticum chuanxiong hort extract is ligusticum chuanxiong hort essential oil.
Furthermore, the external preparation is prepared by taking the raw materials as active ingredients and adding auxiliary materials acceptable in skin care products.
Further, the external preparation is a solution, a spray or a film agent.
Furthermore, the solution or the spray is prepared from the following raw materials in parts by weight:
10-20 parts of ethyl butyl acetaminopropionate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-20 parts of ligusticum wallichii extract, 5-10 parts of citronella extract, 0.1-1 part of thymol, 30-60 parts of ethanol, 51-102 parts of water, 2-4 parts of 1, 2-pentanediol, 0.1-0.2 part of essence, 0.5-1 part of borneol, 0.5-1 part of triethanolamine, 5-10 parts of butanediol and 1-2 parts of ascorbyl palmitate.
Furthermore, the solution or the spray is prepared from the following raw materials in parts by weight:
10 parts of ethyl butyl acetaminopropionate, 1 part of menthol, 1 part of menthone glycerol ketal, 10 parts of ligusticum wallichii extract, 10 parts of citronella extract, 1 part of thymol, 30 parts of ethanol, 51 parts of water, 2 parts of 1, 2-pentanediol, 0.1 part of essence, 0.5 part of borneol, 0.5 part of triethanolamine, 5 parts of butanediol and 1 part of ascorbyl palmitate.
The invention also provides a preparation method of the composition, which comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) mixing ethyl butylacetylaminopropionate, menthone glycerol ketal, ascorbyl palmitate and ethanol to obtain phase A; dissolving menthol, rhizoma Ligustici Chuanxiong extract, herba Cymbopogonis Citrari extract, thymol, essence and Borneolum Syntheticum in 1, 2-pentanediol, triethanolamine and butanediol to obtain phase B;
(3) heating water to 90 deg.C, keeping the temperature for 20 min, cooling to 45 deg.C, adding A, B, mixing, and stirring.
The invention also provides an application of the composition in preparing a skin care product for repelling mosquitoes and relieving itching.
Further, the skin care product is a moisturizing and/or cooling skin care product.
Furthermore, the skin care product is a mosquito repellent and/or itching relieving skin care product.
The invention finally provides a preparation method of the ligusticum wallichii essential oil, which comprises the following steps:
1) extracting rhizoma Ligustici Chuanxiong decoction pieces with supercritical carbon dioxide in a supercritical carbon dioxide extractor to obtain essential oil;
2) filtering the essential oil obtained in the step 1), concentrating the filtrate, filtering again, and standing to obtain the product.
Further, the extraction parameters of the extractor in the step 1) are as follows:
the filtration is performed by using 200-mesh filter cloth; the concentration temperature is 60 +/-5 ℃, and the time is 1-2 h; the mixture was allowed to stand for 90 days.
The composition contains natural plant essence of the ligusticum wallichii, and can effectively relieve pruritus caused by various external stimuli; the mint can be cool and moist; the thyme can prevent miliaria, resist bacteria and avoid insects, and the citronella extract can expel wind and reduce swelling and relieve dizziness; and other cosmetic raw materials are added, so that the red and swollen bites, miliaria and pruritus can be effectively relieved, the head is faint, and the problems of environmental odor and flying insect breeding are solved to a certain extent.
Clinical tests prove that the composition has obvious effect on inhibiting skin itch, takes effect quickly, is safe without toxic and side effects, can be used for preventing and treating skin problems such as skin discomfort caused by mosquito bites, skin itch and skin inflammation, and has practical popularization and application values.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of the medicament of the invention
The formula is as follows:
10g of butyl ethyl levulinate, 1g of menthol, 1g of menthone glycerol ketal, 10g of ligusticum wallichii essential oil, 10g of citronella extract, 1g of thymol, 30g of ethanol, 51g of water, 2g of 1, 2-pentanediol, 0.1g of essence, 0.5g of borneol, 0.5g of triethanolamine, 5g of butanediol and 1g of ascorbyl palmitate.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) mixing ethyl butylacetylaminopropionate, menthone glycerol ketal, ascorbyl palmitate and ethanol to obtain phase A; dissolving menthol, rhizoma Ligustici Chuanxiong essential oil, herba Cymbopogonis Citrari extract, thymol, essence and Borneolum Syntheticum in 1, 2-pentanediol, triethanolamine and butanediol to obtain phase B;
(3) heating water to 90 deg.C, keeping the temperature for 20 min, cooling to 45 deg.C, adding A, B, mixing, and stirring.
Example 2 preparation of the inventive Agents
The formula is as follows:
20g of butyl ethyl levulinate, 2g of menthol, 2g of menthone glycerol ketal, 20g of ligusticum wallichii essential oil, 20g of citronella extract, 2g of thymol, 60g of ethanol, 102g of water, 4g of 1, 2-pentanediol, 0.2g of essence, 1g of borneol, 1g of triethanolamine, 10g of butanediol and 2g of ascorbyl palmitate.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) mixing ethyl butylacetylaminopropionate, menthone glycerol ketal, ascorbyl palmitate and ethanol to obtain phase A; dissolving menthol, rhizoma Ligustici Chuanxiong essential oil, herba Cymbopogonis Citrari extract, thymol, essence and Borneolum Syntheticum in 1, 2-pentanediol, triethanolamine and butanediol to obtain phase B;
(3) heating water to 90 deg.C, keeping the temperature for 20 min, cooling to 45 deg.C, adding A, B, mixing, and stirring.
Example 3 preparation of the inventive Agents
The formula is as follows:
15g of butyl ethyl levulinate, 1.5g of menthol, 1.5g of menthone glycerol ketal, 15g of ligusticum wallichii essential oil, 15g of citronella extract, 1.5g of thymol, 45g of ethanol, 76.5g of water, 3g of 1, 2-pentanediol, 0.15g of essence, 0.75g of borneol, 0.75g of triethanolamine, 7.5g of butanediol and 1.5g of ascorbyl palmitate.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) mixing ethyl butylacetylaminopropionate, menthone glycerol ketal, ascorbyl palmitate and ethanol to obtain phase A; dissolving menthol, rhizoma Ligustici Chuanxiong essential oil, herba Cymbopogonis Citrari extract, thymol, essence and Borneolum Syntheticum in 1, 2-pentanediol, triethanolamine and butanediol to obtain phase B;
(3) heating water to 90 deg.C, keeping the temperature for 20 min, cooling to 45 deg.C, adding A, B, mixing, and stirring.
The advantageous effects of the present invention are described below by way of test examples.
Test example 1 clinical test
The cooling liquid is tried by the volunteers by adopting a civil survey grading method, and a test table is filled to comprehensively evaluate.
Volunteers (18-38 years old, 100 persons; 38-58 years old, 100 persons) in different age groups are respectively selected as trial objects, the trial objects are smeared on the back of a hand for 1 time every day, the trial objects are continuously used for three months, and a test table is filled for scoring after trial. The using effect of each item in the scoring table is divided into 5 points in total: score 5 is the highest score, indicating very satisfactory; 4 points are better and relatively satisfactory; score 3 is acceptable; an unacceptable range is 3 or less. The average score of each using effect is shown in table 1. (Note: the cooling liquid prepared from the traditional Chinese medicine composition of the embodiments 1-3 of the present invention is used as a test sample).
Table 1 test results of comprehensive effects of mosquito-repelling and itching-relieving composition products of the present invention
| Effects of use | Example 1 | Example 2 | Example 3 |
| Degree of moisture retention | 4.98 | 4.98 | 4.98 |
| Mosquito repelling device | 4.80 | 4.97 | 4.93 |
| Relieving itching | 4.90 | 5.00 | 4.93 |
| Degree of irritation | 4.94 | 4.92 | 4.94 |
| Feeling of coolness | 4.92 | 4.98 | 4.96 |
As shown in table 1, the liquid prepared from the traditional Chinese medicine composition in embodiments 1 to 3 of the present invention has good effects of moistening skin, keeping moisture, cooling, and no irritation, especially good effects of relieving itching of skin, and is highly acceptable by the audience and people.
Experimental example 2 preparation and Effect test of Ligusticum chuanxiong Hort extract-Ligusticum chuanxiong Hort essential oil
1. Pretreatment
Cleaning rhizoma Ligustici Chuanxiong, crushing, and drying to obtain rhizoma Ligustici Chuanxiong decoction pieces;
2. supercritical carbon dioxide extraction of essential oil
(1) Adding carbon dioxide in supercritical state into rhizoma Ligustici Chuanxiong decoction pieces, and extracting with supercritical carbon dioxide extractor to obtain essential oil, wherein the specific extraction parameters are shown in Table 2:
TABLE 2 supercritical extraction Process parameters
(2) And (3) filtering: filtering with 200 mesh filter cloth for three times;
(3) concentration: concentrating with rotary evaporator, recovering ethanol, and controlling concentration temperature at 60 + -5 deg.C for 1-2 hr;
(4) and (3) filtering: filtering the concentrated essential oil with 200 mesh filter cloth for 2 times;
(5) standing: standing for 90 days to obtain;
3. mosquito repellent effect test of ligusticum wallichii essential oil
The prepared ligusticum wallichii essential oil is combined with permethrin and a high polymer slow release agent to prepare PD-1, PD-2 and PD-3 long-acting repellents, a repellent effect test is carried out on the termite albopictus in a laboratory, and compared with the repellent effects of Deet crude oil and 3 commercially available repellents, the results are as follows: human body presses 1.5μV cm2Or 1.5mg/cm2After treatment, the effective protection rate of the PD type repellent reaches over 90 percent, and the PD type repellent is obviously superior to Deet crude oil and commercial repellent and has obvious effect.
4. Analysis of effect of Ligusticum chuanxiong essential oil mosquito repellent prepared by supercritical carbon dioxide extraction
The effect of the supercritical carbon dioxide extraction of the essential oil for avoiding mosquitoes is better:
1) the distillation extraction temperature is too high, so that the top note components are difficult to recover; the heating temperature is kept at 100 ℃ or above, so that some components (such as wax and the like) with low volatility are also brought out and mixed into the essential oil, the quality of the essential oil is seriously influenced by excessive wax components, the essential oil extracted by supercritical carbon dioxide has no problems, and the mosquito repelling effect is better;
2) the distillation extraction oil-water separation is difficult: the ligusticum wallichii essential oil is a mixture consisting of a plurality of micromolecular compounds, has certain water solubility, and a large amount of water is added in distillation extraction, so that the oil-water ratio is increased, the essential oil is difficult to separate from water, and the critical carbon dioxide extraction uses an organic solvent, so that the essential oil can be volatilized at normal temperature, and the quality of the essential oil is improved.
Test example 3 comparative test
1. Test drugs
Comparative 1 group composition: 30% of extract components (10-20 parts of ethyl butyl levulinate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-10 parts of citronella extract and 0.1-1 part of thymol), 20% of ethanol and 50% of deionized water
Comparative 2 group composition: 30% of ligusticum wallichii containing essential oil component (10-20 parts of ethyl butyl levulinate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-20 parts of ligusticum wallichii essential oil, 5-10 parts of citronella extract and 0.1-1 part of thymol), 20% of ethanol and 50% of deionized water
Comparative 3 group composition: 30% of ligusticum wallichii essential oil, 20% of ethanol and 50% of deionized water
2. Test method
And (4) adopting a civil survey grading method, and comprehensively evaluating by asking volunteers to try three comparison group samples, filling out a trial table and observing by experimenters.
Volunteers (18-38 years old, 30 persons; 38-58 years old, 30 persons) in different age groups are respectively selected as trial test objects.
Test method 1: a sample of a fixed volume comparison group is taken and smeared on the arms of both hands of a volunteer, the hands are placed in a fixed cage, a certain number of female mosquitoes are in the cage, the number of times of biting is counted from the beginning of placing the female mosquitoes in the cage, and after 1 hour, the biting results and the using feeling scores of each group are observed and compared. The usage scoring items refer to the effects of relieving itching, stimulating feelings and overall experience comfort.
The test method 2 comprises the steps of taking samples of a fixed volume comparison group, smearing the samples on arms and legs of volunteers, enabling each group of volunteers to walk in a forest, and carrying out effective duration registration and use scoring every two hours. The usage scoring items refer to relieving and itching relieving effects, stimulating feelings and overall experience comfort level in the using process
The total using effect of each item in the score is 5 points: score 5 is the highest score, indicating very satisfactory; 4 points are better and relatively satisfactory; score 3 is acceptable; an unacceptable range is 3 or less. The number of bites is counted.
3. Test results
The results of the test of the effect of the 3 comparative drugs are shown in tables 3 and 4
TABLE 3 comparison of the results of the test of the comprehensive effects according to test method 1
| Effects of use | Comparative group 1 | Comparative group 2 | Comparative group 3 |
| Number of bites | 18 times of | 6 times of | 13 times (twice) |
| Relieving itching | 4.5 | 4.96 | 4.80 |
| Degree of irritation | 4.84 | 4.96 | 4.67 |
| Feeling of comfort | 4.88 | 4.93 | 4.78 |
TABLE 4 comparison of the test results of the comprehensive effects according to test method 2
| Effects of use | Comparative group 1 | Comparative group 2 | Comparative group 3 |
| Duration of validity | 1-2 hours | 6 to 8 hours | 4-6 hours |
| Relieving itching | 4.56 | 4.86 | 4.70 |
| Degree of irritation | 4.81 | 4.93 | 4.67 |
| Feeling of comfort | 4.86 | 4.90 | 4.83 |
From tables 3 and 4, it can be seen that: compared with the composition consisting of the group 3, the mosquito repellent and itching relieving effects and the use comfort degree are better than the effects of the composition without the ligusticum wallichii extract or only taking the ligusticum wallichii extract as an active ingredient.
In conclusion, the traditional Chinese medicine composition has good effect, quick response, is natural, safe and non-irritant, can effectively relieve skin itch, dispel mosquitoes and relieve itching, has long mosquito dispelling time and no irritation as proved by clinical tests, and can be used for preventing and treating skin problems such as skin discomfort caused by mosquito bites and skin itch.
Claims (15)
1. Application of rhizoma Ligustici Chuanxiong and its extract in preparing topical preparation with mosquito repellent and itching relieving effects is provided.
2. Use according to claim 1, characterized in that: the rhizoma Ligustici Chuanxiong extract is rhizoma Ligustici Chuanxiong essential oil.
3. Use according to claim 1, characterized in that: the rhizoma Ligustici Chuanxiong essential oil is extract of rhizoma Ligustici Chuanxiong rhizome by supercritical carbon dioxide extraction.
4. The mosquito-repellent itching-relieving composition is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
10-20 parts of ethyl butyl levulinate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-20 parts of ligusticum wallichii extract, 5-10 parts of citronella extract and 0.1-1 part of thymol.
5. The pharmaceutical composition of claim 4, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
10 parts of ethyl butyl levulinate, 1 part of menthol, 1 part of menthone glycerol ketal, 10 parts of ligusticum wallichii extract, 10 parts of citronella extract and 1 part of thymol.
6. The composition according to claim 4 or 5, characterized in that: the rhizoma Ligustici Chuanxiong extract is rhizoma Ligustici Chuanxiong essential oil.
7. The composition according to any one of claims 4 to 6, wherein: the external preparation is prepared by taking the raw materials as active ingredients and adding acceptable auxiliary materials in skin care products.
8. The composition of claim 7, wherein: the external preparation is a solution, a spray or a film agent.
9. The composition of claim 8, wherein: the solution or the spray is prepared from the following raw materials in parts by weight:
10-20 parts of ethyl butyl acetaminopropionate, 1-2 parts of menthol, 1-6 parts of menthone glycerol ketal, 5-20 parts of ligusticum wallichii extract, 5-10 parts of citronella extract, 0.1-1 part of thymol, 30-60 parts of ethanol, 51-102 parts of water, 2-4 parts of 1, 2-pentanediol, 0.1-0.2 part of essence, 0.5-1 part of borneol, 0.5-1 part of triethanolamine, 5-10 parts of butanediol and 1-2 parts of ascorbyl palmitate.
10. The composition of claim 9, wherein: the solution or the spray is prepared from the following raw materials in parts by weight:
10 parts of ethyl butyl acetaminopropionate, 1 part of menthol, 1 part of menthone glycerol ketal, 10 parts of ligusticum wallichii extract, 10 parts of citronella extract, 1 part of thymol, 30 parts of ethanol, 51 parts of water, 2 parts of 1, 2-pentanediol, 0.1 part of essence, 0.5 part of borneol, 0.5 part of triethanolamine, 5 parts of butanediol and 1 part of ascorbyl palmitate.
11. A method of preparing the composition of claim 9, wherein: it comprises the following steps:
(1) weighing the raw materials according to the proportion of claim 9;
(2) mixing ethyl butylacetylaminopropionate, menthone glycerol ketal, ascorbyl palmitate and ethanol to obtain phase A; dissolving menthol, rhizoma Ligustici Chuanxiong extract, herba Cymbopogonis Citrari extract, thymol, essence and Borneolum Syntheticum in 1, 2-pentanediol, triethanolamine and butanediol to obtain phase B;
(3) heating water to 90 deg.C, keeping the temperature for 20 min, cooling to 45 deg.C, adding A, B, mixing, and stirring.
12. Use of the composition of any one of claims 4 to 10 in the preparation of a mosquito repellent antipruritic skin care product.
13. Use according to claim 11, characterized in that: the skin care product is a moisturizing, cooling, mosquito repelling and/or itching relieving skin care product.
14. A preparation method of ligusticum wallichii essential oil is characterized by comprising the following steps: it comprises the following steps:
1) extracting rhizoma Ligustici Chuanxiong decoction pieces with supercritical carbon dioxide in a supercritical carbon dioxide extractor to obtain essential oil;
2) filtering the essential oil obtained in the step 1), concentrating the filtrate, filtering again, and standing to obtain the product.
15. The method of claim 14, wherein: the extraction parameters of the extractor in the step 1) are as follows:
the filtration is performed by using 200-mesh filter cloth; the concentration temperature is 60 +/-5 ℃, and the time is 1-2 h; the mixture was allowed to stand for 90 days.
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