JPH09100236A - Bathing agent containing both antibody production inhibitor and skin softening agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject bathing agent suitable for mitigating symptoms such as atopic dermatitis. SOLUTION: This bathing agent contains 0.1-10wt.% of an antibody production inhibitor selected from chamomile extract, cnidium rhizome extract, angericae radix extract, orange peel extract, buttock extract, royal jelly extract and birch extract and 0.1-50wt.% of a skin softening agent consisting of rice germ oil or pinecone extract. This agent further contains optional ingredients in common use and clan be prepared into a bathing agent f liquid type, capsular type (with a liquid matter encapsulated into a soft capsule), powdery type, expanded tablet type, tablet type, pasty type, etc. This agent is effective for restoring dry skin due to e.g. atopic dermatitis into normal skin.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antibody production inhibitor, a skin softening agent, and a bath agent containing the antibody production inhibitor and a skin softening agent.

[0002]

2. Description of the Related Art It has been empirically known since ancient times that bathing has a positive effect on treatment of diseases. For example, it is said that the public baths in Rome were often used for the purpose of treating skin diseases such as Hansen's disease. Furthermore,
It is known that noble women used hot springs to clean their skin in China. There was a custom of hot spring healing in Japan that heals illness. Such a phenomenon is because various trace components dissolved in hot water such as hot springs work favorably through the skin of the whole body. That is, in the hot spring, the whole body's skin absorbs the drug, which is suitable for treatment.

On the other hand, in recent years, along with the change in lifestyle centered on eating habits, autoimmune diseases such as systemic lupus erythematosus, periarteritis nodosa, scleroderma, dermatomyositis, rheumatoid arthritis, etc., or allergies. disease,
For example, the number of sufferers of hay fever, hay fever, atopic dermatitis, delayed contact dermatitis, etc. is rapidly increasing. In particular, the number of patients with hay fever etc. is expanding to the extent that one in three people is affected, and not only spring cedar pollen, but also types such as camellia, oak, ragweed, and goldengrass, and therefore the season is widespread. Can be seen all year round.

In these autoimmune diseases, the existence of various autoantibodies and autoantigen-sensitized lymphocytes has been confirmed based on excessive activity of antibody-producing cells. Based on cell-antibody and killer cell-dependent reactions,
It has also been experimentally proven to have tissue damage. Also, behind the development of allergic diseases, excessive antibody-producing cell activity has been reported. These are hypercorresponding reactions of the human body to external stimuli. Further, the activation of the activity of antibody-producing cells is said to be one of the indicators of the over-correspondence reaction of the human body.

For the treatment of such allergic diseases and autoimmune diseases, administration of antihistamines, steroids and the like has been conventionally performed as a symptomatic treatment. However, even if these drugs are used, a sufficient effect cannot be obtained, and there are problems in that side effects are large and long-term continuous administration cannot be performed. Under such circumstances, there has been a demand for a drug or a treatment method that suppresses the reaction to respond to the human body. Therefore, finding a safe, easy, and easy means of suppressing antibody production brings a gospel to patients with such diseases.

Further, in such diseases, especially allergic diseases, inflammation, itchiness, caused by excessive reaction of antibody production, even if antibody production is suppressed,
It is known that various symptoms such as redness persist even after antibody production is suppressed. This is because the immune reaction system occurs through a complicated procedure in the living body, and such a living person remains even after the antibody production is suppressed. Therefore, in order to deal with allergic diseases, it is necessary to deal with such inflammation and redness. At present, there is no cure that satisfies these conditions.

[0007]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and it is possible to safely and quickly suppress antibody production in patients with allergic diseases such as patients with atopic dermatitis and to prevent redness. It is an object to provide a means for easily improving the symptoms such as.

[0008]

[Means for Solving the Problems] On the basis of the above-mentioned circumstances, the present inventors keep in mind that bathing is an effective treatment method for diseases, and by bathing, patients with allergic diseases such as atopic dermatitis can be treated. On the other hand, as a result of earnestly working hard to find a means of suppressing antibody production and relieving symptoms such as inflammation, systemic transdermal administration of chamomile extract, senkyu extract, spruce extract, spruce extract, perilla extract, royal jelly extract, birch extract The inventors have found that administration suppresses antibody production, and that rice germ oil and matsukasa extract soften and improve the skin condition, and completed the invention.

That is, the present invention relates to chamomile extract, senkyu extract, touki extract, spruce extract, perilla extract,
The present invention relates to a bath agent containing an antibody-producing agent selected from royal jelly extract and birch extract and a skin softening agent selected from rice germ oil and matsukasa extract.

The present invention will be described in detail below. (1) Antibody Production Inhibitor of the Present Invention The antibody production inhibitor of the present invention is a chamomile extract, senkyu extract, spruce extract, spruce extract, perilla extract,
Consists of one or more selected from royal jelly extract and birch extract. Here, chamomile is a general term for asteraceae chamomile (Matricaria chamomilla), and examples thereof include Roman chamomile German chamomile and the like. The senkyu is the Umbelliferae Cnidium officin
ale) is the generic name of the root. Touki is a generic name for the roots of the Angelica sinensis species. Spruce is a general term for fruits of the orange family (Citrus aurantiumu L.). A perilla is a perilla frutescens ((Perilla frutescens
(L.) Britt.var.crispa Decne)
Aojiso etc. are mentioned. A birch is a birch family (Be
It is a general term for plants of tulaceae), and can be exemplified by plants of the genus Betula (Betula), the genus Hazel (Corylus), and the genus Alnus (Alnus), such as birch, date citrus, and Yogomi Minebari.
Among these, the plant of the genus Birch is most suitable as a source of the birch extract of the present invention. These essences are those obtained by drying a part or all of these plants, processing them by crushing, dried products or extracts extracted with a solvent from the processed product, and a concentrate obtained by removing the solvent therefrom, It is a generic term for purified products obtained by fractional purification. Any of these can be used as the antibody production inhibitor of the present invention. Most preferred of these are concentrates of solvent extracts. The solvent used for extraction is not particularly limited,
Polar solvents are preferable, for example, water, alcohols such as ethanol and butanol, ketones such as acetone and methyl ethyl ketone, polyhydric alcohols such as glycerin and 1,3-butanediol, ethers such as diethyl ether and tetrahydrofuran, chloroform. And at least one selected from halogenated hydrocarbons such as methylene chloride. Among these, more preferable is one or more selected from water, alcohols, and polyhydric alcohols. Extraction using these may be performed according to a conventional method, for example,
At room temperature, it may be dipped in about 10 times the amount of solvent for several days,
If the temperature is near the boiling point, the same solvent may be used for heating and immersion for several hours. Removal of the solvent may be carried out by vacuum distillation or the like as usual. The most preferable method of preparing these extracts is the one obtained by removing the solvent from the ethanol aqueous solution extract. This is because polar and non-polar components can be extracted and there is no problem in the safety of the residual solvent. Further, as the royal jelly, a honey bee secretion and / or a purified product thereof which are usually commercially available may be used. The antibody production inhibitor of the present invention may be used alone or in combination of two or more kinds. All of these are commercially available and there is no problem in obtaining them.

(2) Antibody Production Inhibitory Action The antibody production inhibitory action of the antibody production inhibitor of the present invention is a hemolytic plaque method (Science, 14) developed by Jern et al.
0,405,1963), the number of antibody-producing cells in splenocytes was counted and measured.

That is, a group of 6 animals, 60 weeks old, aged ddy
5 g / mouse of the antibody production inhibitor of the present invention using male mice of the strain
The mouse was immersed in a physiological saline solution or dispersion containing about 40 ° C. at a concentration of ml for 5 minutes. As the antibody production inhibitor of the present invention, the extract used was a solvent-removed product of a 50% ethanol aqueous solution extract.

Then, all mice were sensitized by administering 0.25 ml of 4 × 10 ⁸ cells / ml of sheep red blood cells (SRBC). The same samples as those administered before the sensitization were administered three times in total on the first day, second day and third day after the sensitization. On day 4, the spleens of the mice in each group were taken out, and the antibody-producing cells in the splenocytes were detected according to the method of Jern et al. In this method, the antibody-producing ability is represented by the number of antibody-producing cells per mouse. The antibody production cell inhibition rate is expressed as a value obtained by dividing the antibody production ability of the control group by the antibody production cell inhibition ability of the antibody production inhibitor administration group by 100. In this evaluation, the antibody-producing cell inhibition rate was calculated using the average value of each group. Table 1 shows the results. From this, it is understood that the antibody production inhibitor of the present invention exerts an excellent antibody production inhibitory effect by immersion administration. Furthermore, since the dose of the antibody production inhibitor of the present invention is large, it is clear that it is excellent in safety.

[0014]

[Table 1]

(3) Skin Softening Agent of the Present Invention The skin softening agent of the present invention comprises rice germ oil and / or matsukasa extract. Rice germ oil is an oil and fat component containing triglyceride as a main component contained in rice germ, and may contain some water-soluble components and components having a surface active action. In order to obtain this rice germ oil from rice, rice having germs or germs of rice may be extracted with a solvent or squeezed out. The rice is not particularly limited as long as it is rice of rice family, and may be non-glutinous rice or glutinous rice, indica rice, japonica rice, or a mixed variety thereof. When these rices are extracted with a solvent to obtain rice germ oil, preferable solvents include alcohols, ethers, halogenated hydrocarbons, and hydrocarbons such as normal hexane and petroleum ether. In addition, pine tree genus (Abies), genus Tsuga (Tsuga), pine genus (Pinus), spruce genus (Pice)
a), Larch, Larix, Pseudola
rix), a general term for female flowers or fruits of plants of the genus Cedrus, and is not limited to its maturity. The definition and manufacturing method of this essence are in accordance with the essence described for the antibody production inhibitor. In the present invention, these skin softening agents may be used alone or in combination.

(4) Skin Softening Action The skin softening agent of the present invention softens rough and bulky skin,
Excellent in freshening effect. This action is effective for restoring the skin that has become bulky due to atopic dermatitis to a normal state.

(5) Bath Agent of the Present Invention The bath agent of the present invention is characterized by containing the above-mentioned antibody production inhibitor and a skin softening agent. The preferable compounding amount of the antibody production inhibitor is 0.01 to 10% by weight. This is because if it is less than 0.01% by weight, the antibody production inhibitory action cannot be expected, and if it exceeds 10% by weight, the action will reach the ceiling. More preferred is 0.1 to 5% by weight. In addition, the preferable blending amount of the skin softening agent is 0.1 to 80% by weight, which has a clear effect.
More preferably, it is 1 to 50% by weight, where the effect is dose-dependent. In the present invention, in addition to these essential components, optional components usually used in bath preparations may be added. As optional components, oils and fats, inorganic salts, fragrances, surfactants, fatty acids, polyhydric alcohols, alcohols, thickeners, preservatives,
Colorants, powders, foaming agents, antifoaming agents, various medicinal ingredients, herbs and the like.

The form of the bath preparation of the present invention is not particularly limited as long as it contains the essential components of the present invention.
For example, the dosage form may be a liquid type, a type in which a liquid substance is enclosed in a soft capsule, a powder type, a tablet effervescent type, a tablet type, a pasty type or the like. The bath agent of the present invention can be formulated into these preparations from the essential and optional components by a conventional method.

[0019]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in more detail below with reference to examples, but it goes without saying that the present invention is not limited to these examples.

Examples 1 to 7 The components shown in Table 2 were weighed and dissolved by stirring at room temperature to obtain a liquid bath agent.

[0021]

[Table 2]

Examples 8 to 14 The components shown in Table 3 were weighed and dissolved by stirring at room temperature to obtain a liquid bath agent.

[0023]

[Table 3]

Examples 15 to 21 The components shown in Table 4 were weighed and kneaded with a kneader to obtain a powder bath agent.

[0025]

[Table 4]

[0026]

【Example】

Example 1 Actual Use Test Regarding the bath agents of Examples 1 and 2 of the above-described embodiment of the present invention, an actual use test was conducted on 10 persons suffering from atopic dermatitis with Comparative Examples 1 to 6 shown in Table 5 as controls. Then, the degree of improvement of atopic dermatitis was observed. Table 6 shows the results. From this, it can be seen that the bath agent of the present invention is effective in improving atopic dermatitis. Further, no unfavorable reaction such as inflammation was observed during the actual use test, and it is clear that the bath preparation of the present invention has high safety.

[0027]

[Table 5]

[0028]

[Table 6]

[0029]

The bath agent of the present invention is very useful because it can improve atopic dermatitis.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁶ Identification code Office reference number FI Technical display area A61K 35/78 A61K 35/78 T ADC ADCU 7/00 7/00 K 7/48 7/48 7 / 50 7/50 35/64 AED 35/64 AED

Claims (7)

[Claims] 1. An antibody production inhibitor comprising one or more selected from chamomile extract, senkyu extract, touki extract, spruce extract, perilla extract, royal jelly extract and birch extract. 2. A skin softening agent comprising rice germ oil or Matsukasa extract. 3. A bath agent containing the antibody production inhibitor according to claim 1 and the skin softening agent according to claim 2. 4. The bath agent according to claim 3, wherein the content of the skin softening agent according to claim 2 is 0.1 to 50% by weight. 5. The content of the antibody production inhibitor according to claim 1 is 0.1 to 10% by weight.
Or the bath agent described in 4 above. 6. A bath preparation containing one or more kinds selected from chamomile extract, senkyu extract, touki extract, spruce extract, perilla extract, royal jelly extract and birch extract and rice germ oil or matsukasa extract. 7. One or more selected from chamomile extract, senkyu extract, touki extract, spruce extract, perilla extract, royal jelly extract, and birch extract in an amount of 0.1 or more.
-10 wt% and rice germ oil or matsukasa extract 0.1
The bath agent according to claim 6, containing 50% by weight.