CN101780020A - Cool and refreshing toilet water capable of relieving itching and expelling mosquito - Google Patents
Cool and refreshing toilet water capable of relieving itching and expelling mosquito Download PDFInfo
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- CN101780020A CN101780020A CN201010112216A CN201010112216A CN101780020A CN 101780020 A CN101780020 A CN 101780020A CN 201010112216 A CN201010112216 A CN 201010112216A CN 201010112216 A CN201010112216 A CN 201010112216A CN 101780020 A CN101780020 A CN 101780020A
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- anophelifuge
- refrigerant
- antipruritic
- floral water
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Abstract
The invention discloses a cool and refreshing toilet water capable of relieving itching and expelling mosquito, comprising the following components in percentage by weight: 40-75% of edible alcohol, 0.1-2% of peppermint derivative, 0.1-2% of salicylic acid derivative, 1-20% of humectant, 1-15% of plant mosquito repellent, 1-10% of synthesized mosquito repellent, and water as the rest. The toilet water has the effect of slowly releasing refrigerant and is capable of keeping cool for a long time and diminishing inflammation without stimulating skin by reducing the permeation rate of salicylic acid, thereby avoiding irritant effect for skin and improving the comfort when in use; and the artificially synthesized mosquito repellent is complexly used with natural mosquito repellent, thereby improving the mosquito repelling effect and prolonging the mosquito repelling time and decreasing the toxicity of synthesized mosquito repellent with relatively higher safety.
Description
Technical field
The mosquito-repellent perfume that the present invention relates to use in the daily life, particularly a kind of floral water with refrigerant, antipruritic, antiinflammatory, function of driving mosquitoes.
Background technology
Mosquito-repellent perfume is a kind of aqueous solution that contains ethanol, anophelifuge, delays evaporable wetting agent and essence; in order to reach the algefacient effect; usually contain Mentholum in the floral water; but the sporadic and refrigerant property of Mentholum can be explosive strong because of it, so can bring the cool irritability reaction that also can cause skin.For reaching the antiinflammatory effect, be added with salicylic acid usually, but salicylic permeability is too high, can bring zest to skin so again, and increases the drying property of skin.Therefore, the use comfort of existing floral water has much room for improvement.
Insecticide to the human and animal bring create disturbances to, injury and life threatens, also can cause such as: influence is slept, is spread disease, destroys environment, causes the poor harvest of crops.Therefore, the human the whole bag of tricks class that adopts is resisted the harm that insecticide brings.
Resist the main employing insecticide of insecticide, but utilization of pesticides regular meeting brings toxicity problem, and cause the problem of environmental protection aspect, therefore prevention becomes more important.Insect repellent is exactly to be used for reaching stoping the effect that stops and damage on the insect host, reduced the chance that insecticide contact with the host, has reduced the possibility that the host is infected and influence.
Traditional synthetic anophelifuge has diethyltoluamide (DEET), dimethyl phthalate (DMP), dimethyl phthalate etc.
Diethyltoluamide (DEET) is the nineteen forty-two exploitation, and it has the wide spectrum repellent action, and most hematophagus is had effect preferably, and cost performance is very superior, extensive use in worldwide, but a large amount of the use has potential hazardness.Dimethyl phthalate (DMP) and other repellant be composite to have good repelling effect, the material purity height, and cost performance is good, has certain competitiveness.
Summary of the invention
For addressing the above problem, the purpose of this invention is to provide a kind of refrigerant, antipruritic, anophelifuge floral water, it can play anophelifuge, refrigerant, antiinflammatory, itching relieving effect, has improved the use comfort simultaneously.
The object of the present invention is achieved like this: a kind of refrigerant, antipruritic, anophelifuge floral water, it is characterized in that: count by weight percentage, its prescription comprises following component: edible ethanol 40～75%, Herba Menthae derivant 0.1～2%, salicyclic acid derivatives 0.1～2%, wetting agent 1～20%, plant anophelifuge 1～15%, synthetic anophelifuge 1～10%, water surplus.
Described Herba Menthae derivant is selected from one or more mixing in Herba Menthae lactate, Herba Menthae glycerol ketals, the Herba Menthae glycerol acetonide ether.
Described salicyclic acid derivatives is selected from one or more mixing of Radix Acaciae senegalis polysaccharide and salicylic acid complex, salicylic acid monoethanolamine apoplexy due to endogenous wind.
Described wetting agent is selected from the polymer of polypropylene glycol-28 butyl ether-35.
Described plant anophelifuge is selected from natural Rhizoma Alpiniae Officinarum extract eucalyptol.
Described synthetic anophelifuge is selected from N, N-diethyl-3-methyl benzamide.
The present invention has the effect that delays to discharge freshener, can in long-time, keep refrigerant sense, by reducing salicylic infiltration rate, to reach the effect of antiinflammatory and don't chafe, avoided skin is produced irritating influence, improved the comfort of using, and by composite use with synthetic anophelifuge and natural anophelifuge agent, both improved repelling effect and anophelifuge time, and reduced the toxicity of synthetic anophelifuge again, safety is higher.
The specific embodiment
The present invention is a kind of refrigerant, itching relieving floral water, count by weight percentage, its prescription comprises following component: edible ethanol 40～65%, Herba Menthae derivant 0.1～2%, salicyclic acid derivatives 0.1～2%, wetting agent 1～20%, plant anophelifuge 1～15%, synthetic anophelifuge 1～10%.For further strengthening antibacterial effect, also can add plant extraction liquid with anti-inflammation, for example add plant extraction liquid 0.1～5%.
The plant anophelifuge adopts natural eucalyptol, derive from Rhizoma Alpiniae Officinarum extract, the oil of zingiberaceous plant Hedychium coronarium Koenig (Hedychiumcoronarium Koen.), the twig of canella Camphor tree [Cinnamomum camphora (L.) Presl], extract by quintessence oil that is rich in cineole such as Folium eucalypti globueli (Eucalyptus globulus Labill.) oil content gold-plating, 176～178 ℃ of high boiling points, not volatile, presence is good, so have good repelling effect.Chemical formula is 1,3,3-trimethyl-2-oxygen dicyclo [2.2.2] octane, and molecular formula is:
Eucalyptol accounts for 1～15% of prescription total amount, is more preferably 5～10%.
The chemosynthesis anophelifuge adopts diethyltoluamide, i.e. N, and N-diethyl-3-methyl benzamide (DEET) has good mosquito repelling effect, and diethyltoluamide accounts for 1～10% of prescription total amount, is more preferably 2～5%.
Ethanol of the present invention is edible ethanol, because of the content of its methanol far below national standard.Preferred 95% edible ethanol.Edible ethanol accounts for 40～75% of prescription total amount, is more preferably 40～60%.
The Herba Menthae derivant is selected from Herba Menthae lactate, Herba Menthae glycerol ketals, Herba Menthae glycerol acetonide ethers etc. as freshener.They can provide refrigerant sense when floral water sprays or spreads upon on the skin, can make its derivant slowly be decomposed into Herba Menthae and other compositions under the condition of skin itself, and refrigerant sense and don't chafe slowly are provided, and bring refrigerant pleasant sensation for a long time.The Herba Menthae derivant accounts for 0.1～2%, more preferably 0.3～0.8% of prescription total amount.
Salicyclic acid derivatives is selected from Radix Acaciae senegalis polysaccharide and salicylic acid complex, salicylic acid monoethanol amine etc. as antiinflammatory.Salicylic acid is fat-soluble, can infiltrate the pore deep layer along the greasy sebaceous gland of secretion and cause dermatitis.And the compound physical ability of salicylic acid and Radix Acaciae senegalis polysaccharide reduces the salicylic acid seepage velocity, and changing down reaches 42%, avoids it to enter deep skin, makes its active ingredient rest on skin surface for a long time, effectively solves a difficult problem that causes stimulation when salicylic acid uses.The proportion of salicylic acid and Radix Acaciae senegalis polysaccharide is 1: 0.5～2.Salicyclic acid derivatives accounts for 0.1～2%, more preferably 0.6～1% of prescription total amount.
Wetting agent is selected from the polymer of polypropylene glycol-28 butyl ether-35, this wetting agent is the two soluble substances of profit, its water solublity is slightly larger than oil-soluble, high boiling point, the boiling point height of the azeotropic mixture of forming with other component has reduced volatility, has guaranteed the residence time of anophelifuge at skin, increased anophelifuge timeliness wetting agent and accounted for 1～20% of prescription total amount, more preferably 3～5%.
The preferred Cortex Phellodendri extracting solution of plant extraction liquid has the antiinflammatory poison of dispelling, and is antibacterial, antimicrobial effect, and for example available from the product of Shanghai Laibo Bio-chemical Co. Ltd., preferable amount is 0.2～5%, is more preferably 2～3%.
Embodiment
Each component in the prescription and they percentage by weight (%) in prescription:
| Component | Comparative Examples 1 | Comparative Examples 2 | Comparative Examples 3 | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Ethanol | ??55.0 | ??55.0 | ??55.0 | ??55.0 | ??60.0 | ??63.0 |
| Herba Menthae glycerol acetonide ether | ??0.6 | ??0.6 | ??0.6 | ??0.6 | ??0.6 | ??0.6 |
| Eucalyptol | ??10.0 | ??6.0 | ??7.0 | ??2.0 | ||
| Diethyltoluamide (DEET) | ??8.5 | ??3.0 | ??2.0 | ??7.0 | ||
| Salicyclic acid derivatives | ??0.6 | ??0.6 | ??0.6 | (0.6 salicylic acid: the Radix Acaciae senegalis polysaccharide is 1: 1) | ??1 | ??0.8 |
| Polypropylene glycol-28 butyl ether-35 | ??4.0 | ??4.0 | ??4.0 | ??4.0 | ??4.0 | ??4.0 |
| The Cortex Phellodendri extracting solution | ??2.5 | ??2.5 | ??2.5 | ??2.5 | ??2.5 | ??2.5 |
| Essence | ??1.0 | ??1.0 | ??1.0 | ??1.0 | ??1.0 | ??1.0 |
| Water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
With embodiment 1 is example, and its manufacturing process is as follows:
1. earlier in main agitated kettle, add ethanol, add Herba Menthae glycerol acetonide ether again, stir and make its dissolving evenly;
2. again essence is added and become owner of in the agitated kettle, stir;
3. eucalyptol is added and become owner of in the agitated kettle, stir;
4. diethyltoluamide (DEET) is added and become owner of in the agitated kettle, stir.
5. in heating kettle, the water of surplus is warming up to 75 ℃, adds the complex of salicylic acid and Radix Acaciae senegalis polysaccharide, stir and make its dissolving evenly;
6. treat that the uniform solution of dissolving is cooled to below 45 ℃ in the step 3, add polypropylene glycol-28 butyl ether-35 and Cortex Phellodendri extracting solution, stir;
7. the phase of the heating in the step 44 is added and become owner of in the agitated kettle, stirring and dissolving is even;
8. ready-made product freezing and filtering is finished product.
The finished product that makes has good anophelifuge, refrigerant, antipruritic, the antiinflammatory effect of slow release long-acting.
The anophelifuge efficacy testing
(1) tries worm kind and strain altogether
Aedes albopictus (Aedes albopictus), the normal strain of indoor long-term raising, the back of sprouting wings was not sucked blood female adult mosquito in 4-5 days for measuring.
(2) assay method (GB/T 17322.10-1998)
1, attack test
Growing * wide * high for putting into 300 examination worms in the mosquito cage of 40cm * 30cm * 40cm, after waiting to try worm recovery normally, the back of the hand is exposed 4cm * 4cm skin, remainder tightly covers, hands stretches in the mosquito cage and places 2min, the examination worm that comes to stop falling is qualified for attack more than 30 persons, and this person and mosquito cage worm can be used for repellency test.
2, repellency test
At respectively the draw skin area of 5cm * 5cm of the both hands back of 3 attack eligibles, wherein a hands is a blank, another hands is evenly smeared repellant to be measured by the dosage of 1.5 μ l/cm, exposes 4cm * 4cm skin wherein, tightly covers remainder.Smear repellant after 2 hours, hands is stretched into be placed with 2min in the qualified mosquito cage of attack, observe and to have or not mosquito to come to bite, later on once, make repellant and lost efficacy as long as have a mosquito to come to bite both to have declared every test half an hour.
3, result
After tested, embodiment 1-3 gained formulation samples can reach 8.5 hours to effective repellent guard time of Aedes albopictus.Example 1 blank sample that do not add anophelifuge does not have effective repellent effect to Aedes albopictus in contrast.2 of Comparative Examples contain the sample of diethyltoluamide (DEET) also can accomplish 8.5 hours experiment effect of anophelifuge, but the side effect of synthetic anophelifuge diethyltoluamide (DEET) is to bring certain toxicity.The sample that 3 of Comparative Examples contain eucalyptol also can reach more than 8.5 hours by anophelifuge, its safety non-toxic, and can reach good repelling effect, but non-economically optimal proportion.Embodiments of the invention 1,2,3 can both be accomplished anophelifuge more than 8.5 hours, can reduce the toxicity of this group anophelifuge again.Wherein embodiment 1 is best sexual valence ratio, and repelling effect is good, and its toxicity is low again.
Analyze:
From above instance analysis as can be seen, do not use high-load diethyltoluamide (DEET), do not increase the consumption of synthetic anophelifuge, by with the composite use of natural anophelifuge agent, both improved repelling effect and anophelifuge time, reduced the toxicity of synthetic anophelifuge again.
Claims (10)
1. refrigerant, itching relieving floral water, it is characterized in that: count by weight percentage, its prescription comprises following component: edible ethanol 40～75%, Herba Menthae derivant 0.1～2%, salicyclic acid derivatives 0.1～2%, wetting agent 1～20%, plant anophelifuge 1～15%, synthetic anophelifuge 1～10%, water surplus.
2. according to claim 1 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: also contain plant extraction liquid 0.1～5% in the described prescription.
3. according to claim 1 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described Herba Menthae derivant is selected from one or more mixing in Herba Menthae lactate, Herba Menthae glycerol ketals, the Herba Menthae glycerol acetonide ether.
4. according to claim 1 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described salicyclic acid derivatives is selected from one or more mixing of Radix Acaciae senegalis polysaccharide and salicylic acid complex, salicylic acid monoethanolamine apoplexy due to endogenous wind.
5. according to claim 4 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: the proportion of described salicylic acid and Radix Acaciae senegalis polysaccharide is 1: 0.5～2.
6. according to claim 1 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described wetting agent is selected from the polymer of polypropylene glycol-28 butyl ether-35.
7. according to claim 1 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described plant anophelifuge is selected from natural plant extract eucalyptol.
8. according to claim 7 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described eucalyptol is 1,3,3-trimethyl-2-oxygen dicyclo [2.2.2] octane.
9. according to claim 1 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described synthetic anophelifuge is selected from N, N-diethyl-3-methyl benzamide.
10. according to claim 2 refrigerant, antipruritic, the anophelifuge floral water is characterized in that: described plant extraction liquid is selected from the Cortex Phellodendri extracting solution.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101122169A CN101780020B (en) | 2010-02-09 | 2010-02-09 | Cool and refreshing toilet water capable of relieving itching and expelling mosquito |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101122169A CN101780020B (en) | 2010-02-09 | 2010-02-09 | Cool and refreshing toilet water capable of relieving itching and expelling mosquito |
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| Publication Number | Publication Date |
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| CN101780020A true CN101780020A (en) | 2010-07-21 |
| CN101780020B CN101780020B (en) | 2011-12-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101122169A Active CN101780020B (en) | 2010-02-09 | 2010-02-09 | Cool and refreshing toilet water capable of relieving itching and expelling mosquito |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367529A (en) * | 2014-11-19 | 2015-02-25 | 苏州佑君环境科技有限公司 | Mosquito repellent floral water for purifying air and preparation method of mosquito repellent floral water |
| CN105616406A (en) * | 2010-12-27 | 2016-06-01 | 英特维特国际股份有限公司 | Topical localized isoxazoline formulation |
| CN108739895A (en) * | 2018-06-06 | 2018-11-06 | 钱龙风 | A kind of mosquito-proof ring of perfume atmosphere |
| CN111388372A (en) * | 2020-04-08 | 2020-07-10 | 名臣健康用品股份有限公司 | Plant composition for dispelling mosquitoes, cooling and relieving itching and preparation method thereof |
| CN111481489A (en) * | 2020-05-20 | 2020-08-04 | 四川绿色本草科技发展有限公司 | Ligusticum wallichii extract with mosquito repelling and itching relieving effects and application thereof |
| CN112391838A (en) * | 2020-11-14 | 2021-02-23 | 浙江华康药业股份有限公司 | Cool spray for clothes and preparation method thereof |
-
2010
- 2010-02-09 CN CN2010101122169A patent/CN101780020B/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616406A (en) * | 2010-12-27 | 2016-06-01 | 英特维特国际股份有限公司 | Topical localized isoxazoline formulation |
| CN105616406B (en) * | 2010-12-27 | 2019-12-13 | 英特维特国际股份有限公司 | Topical localized isoxazoline formulations |
| CN104367529A (en) * | 2014-11-19 | 2015-02-25 | 苏州佑君环境科技有限公司 | Mosquito repellent floral water for purifying air and preparation method of mosquito repellent floral water |
| CN108739895A (en) * | 2018-06-06 | 2018-11-06 | 钱龙风 | A kind of mosquito-proof ring of perfume atmosphere |
| CN111388372A (en) * | 2020-04-08 | 2020-07-10 | 名臣健康用品股份有限公司 | Plant composition for dispelling mosquitoes, cooling and relieving itching and preparation method thereof |
| CN111481489A (en) * | 2020-05-20 | 2020-08-04 | 四川绿色本草科技发展有限公司 | Ligusticum wallichii extract with mosquito repelling and itching relieving effects and application thereof |
| CN112391838A (en) * | 2020-11-14 | 2021-02-23 | 浙江华康药业股份有限公司 | Cool spray for clothes and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101780020B (en) | 2011-12-28 |
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Address after: Liannan Chenghai Industrial Zone 515834 area in Guangdong city of Shantou Province Patentee after: MINGCHEN HEALTH Co.,Ltd. Address before: Under the town of Liannan Industrial Zone in Chenghai city of Shantou Province, Guangdong District 515800 Patentee before: GUANGDONG MINGCHEN Co.,Ltd. |
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Effective date of registration: 20221024 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |
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