CN106821803A - A kind of Ligusticum wallichii essential oil composition and its production and use - Google Patents
A kind of Ligusticum wallichii essential oil composition and its production and use Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The invention discloses a kind of Ligusticum wallichii essential oil composition and its production and use.In parts by weight, the Ligusticum wallichii essential oil composition includes following components：0.05~0.1 part of 45~55 parts of Ligusticum wallichii essential oil, 43~50 parts of glycerine, 5~10 parts of peppermint oil and preservative.Preparation method is comprised the following steps：Each component is weighed according to weight part ratio；Each component in addition to preservative is sequentially placed into stirring container, is mixed at room temperature to full and uniform；Add preservative to continue to stir to fully fusion, upper strata free from admixture aliquots are taken after centrifugal treating and obtains the Ligusticum wallichii essential oil composition.Purposes is purposes of the above-mentioned Ligusticum wallichii essential oil composition as skin-care product additive.The Ligusticum wallichii essential oil composition that the present invention is provided is the effects such as have whitening, inducing resuscitation, mosquito repellent, is many effect essential oil products that a kind of simple to operate, raw material is natural and has no toxic side effect.
Description
Technical field
The invention belongs to Chinese medicine health-care technical field, more particularly, it is related to a kind of with work(such as whitening, inducing resuscitation, mosquito repellents
Ligusticum wallichii essential oil composition of effect and its production and use.
Background technology
With the continuous improvement and science and technology development with rapid changepl. never-ending changes and improvements of living standards of the people, the popular demand to cosmetics
Start to be converted from past single nursing type to modern functions type.The active ingredient extracted in Chinese medicine generally has unique function
With the advantage such as curative effect and Small side effects, study hotspot in recent years is turned into as cosmetic additive agent.
In the prior art, the composition for whitening mainly has the kojic acid and ursin for suppressing tyrosinase activity, but its
Stability is poor, with certain light sensitivity.In plant or Chinese herbal medicine extract be used for whitening material have animal placenta extract,
Licorice and endothelin antagonist etc., also suppress the melanocyte transfer of melanin and reach the nicotinoyl of whitening function
Amine and soybean etc..In the essential oil of plant extract, the composition with whitening effect mainly has Rosa Damascana, Lavender, lemon
One or more material of composition compatibility such as lemon essential oil, tea tree ethereal oil, Geranium Essential, Peppermint essential oil, chrysanthemum essential oil.
Ligusticum wallichii is the dry rhizome of Umbelliferae Jehol Ligusticum Rhizome platymiscium Ligusticum wallichii, first recorded in《Sheng Nong's herbal classic》, it is conventional medium-height grass
Medicine, the effects such as with promoting blood circulation and removing blood stasis, promote breath and open depression, wind-expelling pain-stopping.Traditional traditional Chinese medical science thinks that people's complexion is obscure, is because exopathogen is invaded
Attack, qi-blood-body fluid virtual loss, the deficiency of the kidney yin, liver lose that bar reaches, the reason such as the dysfunction of the spleen in transport causes；And facial colour spot is then due to liver depression blood
The stasis of blood, insufficiency of the spleen deficiency of the kidney, QI-blood circulation be not smooth etc., and reason is caused.Whitening should be from removing blood stasis for promoting tissue regeneration, rich in nutrition, promotion metabolism, promotion
The medicine of blood, i.e., with Chinese medicine promoting blood circulation and removing blood stasis and meet the Chinese medicine of cosmetics health specification.Modern pharmacological research is also sent out
Existing, Ligusticum wallichii has stronger inhibitory activity against tyrosinase, and with the effect of stronger removing DPPH free radicals, can be used as U.S.
The development object of white active material.
In now essential oil and pertinent literature is sold, the rare whitening class product based on Ligusticum wallichii.
The content of the invention
With rhizoma chuanxiong volatile oil it is main it is an object of the invention to provide one kind to solve problems of the prior art
Essential oil composition of composition and its production and use.
An aspect of of the present present invention provides a kind of Ligusticum wallichii essential oil composition, in parts by weight, the Ligusticum wallichii essential oil composition
Including following components：0.05~0.1 part of 45~55 parts of Ligusticum wallichii essential oil, 43~50 parts of glycerine, 5~10 parts of peppermint oil and preservative.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, in terms of weight proportion, the Ligusticum wallichii essential oil composition
Including following components：0.08~0.01 part of 48~52 parts of Ligusticum wallichii essential oil, 44~46 parts of glycerine, 7~8 parts of peppermint oil and preservative.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, in parts by weight, the Ligusticum wallichii essential oil composition is also
Including 10~15 parts of 10~15 parts of root of Dahurain angelica essential oil and Radix Astragali essential oil.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, in parts by weight, the Ligusticum wallichii essential oil composition is also
Including 8~15 parts of 10~15 parts of bighead atractylodes rhizome essential oil, 10~15 parts of root of Dahurain angelica essential oil and Rosa Damascana.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, in parts by weight, the Ligusticum wallichii essential oil composition is also
Including 5~10 parts of 5~10 parts of Lavender, 10~15 parts of Rosa Damascana and lemon.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, the Ligusticum wallichii essential oil uses supercritical CO2Extraction
It is obtained by extraction.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, the supercritical CO2Extraction is：By Ligusticum chuanxiong Hort
Particle loads supercritical CO2Extracted in extractor, the use of ethanol is entrainer, it is 50~60 DEG C, extraction to control extraction temperature
Pressure power is 20~30MPa, and the time for controlling each extraction is 1.5~2.5h, and the Ligusticum wallichii essential oil is finally obtained by extraction.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, the Ligusticum chuanxiong Hort particle can cross 30~50 mesh medicines
Allusion quotation is sieved, and the ethanol is ethanol that volumetric concentration is 90~95%.
According to one embodiment of Ligusticum wallichii essential oil composition of the present invention, the preservative is by Nepal tortoise beetle ester, Nepal
It is mixed to get for one or more in golden ethyl ester, Phenoxyethanol and methylisothiazolinone.
Another aspect provides the preparation method of above-mentioned Ligusticum wallichii essential oil composition, it is characterised in that the system
Preparation Method is comprised the following steps：
Each component is weighed according to weight part ratio；
Each component in addition to preservative is sequentially placed into stirring container, is mixed at room temperature to full and uniform；
Add preservative to continue to stir to fully fusion, upper strata free from admixture aliquots are taken after centrifugal treating and obtains the river
Rhizome of chuanxiong essential oil composition.
One embodiment of preparation method according to Ligusticum wallichii essential oil composition of the present invention, it is 3000 to control centrifugal treating rotating speed
~5000r/min, the centrifugal treating time is 5~10min.
Another aspect of the invention provides purposes of the above-mentioned Ligusticum wallichii essential oil composition as skin-care product additive.
The invention provides a kind of Ligusticum wallichii essential oil composition with rhizoma chuanxiong volatile oil as main component and preparation method thereof and
Purposes, is a kind of simple to operate, raw material is natural and has no toxic side effect many effect essential oil products, and additive therefor is less, can
While skin care effect is played, the unnecessary injury to skin is reduced, with effective whitening, inducing resuscitation and mosquito-repelling function, energy
It is enough to be used alone or as additive.
Specific embodiment
All features disclosed in this specification, or disclosed all methods or during the step of, except mutually exclusive
Feature and/or step beyond, can combine by any way.
Any feature disclosed in this specification, unless specifically stated otherwise, can be equivalent or with similar purpose by other
Alternative features are replaced.I.e., unless specifically stated otherwise, each feature is an example in a series of equivalent or similar characteristics
.
Ligusticum wallichii essential oil composition of the present invention and its production and use will be specifically described below.
Traditional Chinese medicine thinks that Ligusticum wallichii has white-skinned face function, and ancient times have used the record of Ligusticum wallichii whitening, in history tree
Also it is on the books.Such as《Prescriptions for Universal Relief》It is smalls with Ligusticum wallichii, each equal portions of cloves, wiping tooth can be as snow-white；《Doctor reflects at all times》With Ligusticum wallichii, ink drought
Lotus, Radix Angelicae Sinensis, tooth soap, root of Dahurain angelica etc. wipe tooth per early, there is permanent tooth, the effect of black palpus；《General Records of Holy Universal Relief》With Ligusticum wallichii, the root of Dahurain angelica, Radix Glycyrrhizae, cassia twig
The day such as (removing tertia), wild ginger takes, and body was all fragrant on 30th；《Guanji side》Single Ligusticum wallichii is used, decocting contains it, and fragrant mouth is deodorant.From the above
Book on Chinese herbal medicine record as can be seen that Ligusticum wallichii is just used for the aspects such as U.S. tooth, hairdressing, fragrant mouth perfume body in ancient times.Meanwhile, Ligusticum wallichii has stronger
Inhibitory activity against tyrosinase and with the effect of stronger removing DPPH free radicals, with reference to tyrosinase inhibition test
Result and remove the result of DPPH free radicals experiment, it is believed that Ligusticum wallichii can be used as the development object of whitening active material.
Based on this, the present invention have developed a kind of Ligusticum wallichii essential oil composition with rhizoma chuanxiong volatile oil as main component, Neng Gouyou
Effect realizes the many-side effect such as whitening, mosquito repellent, inducing resuscitation.
Exemplary embodiment of the invention, in parts by weight, it is described for whitening, inducing resuscitation, mosquito repellent Ligusticum wallichii essential oil
Composition includes following components：45~55 parts of Ligusticum wallichii essential oil, 43~50 parts of glycerine, 5~10 parts of peppermint oil and preservative 0.05~
0.1 part.
Wherein, Ligusticum wallichii essential oil has the ability compared with high inhibition tyrosinase activity, free radical can be effectively removed, in whitening
While skin, it is capable of the aging of delaying skin to a certain extent；On the other hand in the experiment of Ligusticum wallichii essential oil, research finds
Ligusticum wallichii essential oil possesses certain mosquito-repelling function, compared to using chemical method mosquito repellents such as mosquito-repellent incense, insect aerosols, with nontoxic nothing
The effect of public hazards, and the pollution to environment can be reduced.
The peppermint oil that the present invention is added has anti-inflammatory and antalgic, anti-bacteria and anti-virus, promotees infiltration, eliminating the phlegm, spasmolysis and suppression maincenter
Many pharmacological actions such as nervous system, while being used in conjunction with improving the effect of inducing resuscitation skin toner with Ligusticum wallichii essential oil, promote river
The infiltration of rhizome of chuanxiong essential oil.And glycerine has the effect of moisturizing, water lock, may advantageously facilitate the absorption of skin and keep skin moisture and
Gloss.
According to a preferred embodiment of the invention, in parts by weight, the Ligusticum wallichii essential oil composition includes following components：Ligusticum wallichii
0.08~0.01 part of 48~52 parts of essential oil, 44~46 parts of glycerine, 7~8 parts of peppermint oil and preservative.
Additionally, in order to increase Ligusticum wallichii essential oil composition white-skinned face function and improve fragrance, the present invention can also add the bighead atractylodes rhizome,
The extraction of essential oil thing of the root of Dahurain angelica, Radix Astragali Chinese medicine, and Rosa Damascana, lemon and Lavender etc., being formed has unique perfume
The Ligusticum wallichii essential oil composition of taste and effect.
Specifically, according to one embodiment of Ligusticum wallichii essential oil composition of the present invention, the Ligusticum wallichii essential oil composition also includes
10~15 parts of 10~15 parts of root of Dahurain angelica essential oil and Radix Astragali essential oil；According to another embodiment of Ligusticum wallichii essential oil composition of the present invention, institute
Stating Ligusticum wallichii essential oil composition also includes 8~15 parts of 10~15 parts of bighead atractylodes rhizome essential oil, 10~15 parts of root of Dahurain angelica essential oil and Rosa Damascana；According to
The further embodiment of Ligusticum wallichii essential oil composition of the present invention, the Ligusticum wallichii essential oil composition also include 5~10 parts of Lavender,
5~10 parts of 10~15 parts of Rosa Damascana and lemon.
According to the present invention, the Ligusticum wallichii essential oil self-control used in the present invention is obtained, also can be by commercially available.This hair
Bright described self-control Ligusticum wallichii essential oil is preferably by supercritical CO2Extraction is obtained by extraction.Specifically, Ligusticum chuanxiong Hort particle is filled
Enter supercritical CO2Extracted in extractor, the use of ethanol is entrainer, it is 50~60 DEG C, extracting pressure to control extraction temperature
It is 20~30MPa, wherein, the time for controlling each extraction is 1.5~2.5h, and Ligusticum wallichii essential oil is finally obtained by extraction.Wherein, it is above-mentioned
Ligusticum chuanxiong Hort particle can cross 30~50 mesh pharmacopeia sieve, and the ethanol for being used is for ethanol that volumetric concentration is 90~95%.
Peppermint oil of the present invention, Rosa Damascana, lemon, glycerine etc. be it is commercially available, wherein, peppermint oil, rose
The essential oils such as rare essential oil meet standard GB/T/T26516-2011 essential oil quality criteria requirements, and glycerine meets national standard Q/HYH
D34-2008 requirements.Additionally, bighead atractylodes rhizome essential oil, root of Dahurain angelica essential oil, Radix Astragali essential oil can equally take similar with Ligusticum wallichii extraction of essential oil
Method is extracted, it is also possible to buy commercially available prod.
Preservative of the present invention is by Nepal tortoise beetle ester, Nepal gold ethyl ester, Phenoxyethanol and methyl-isothiazol
It is mixed to get for one or more in quinoline ketone.
Invention also provides the preparation method of above-mentioned Ligusticum wallichii essential oil composition.Exemplary implementation of the invention
Example, the preparation method is comprised the following steps：
Each component is weighed according to weight part ratio；
Each component in addition to preservative is sequentially placed into stirring container, is mixed at room temperature to full and uniform；
Add preservative to continue to stir to fully fusion, upper strata free from admixture aliquots are taken after centrifugal treating and obtains the river
Rhizome of chuanxiong essential oil composition.
Wherein it is preferred to control centrifugal treating rotating speed for 3000~5000r/min, the centrifugal treating time is 5~10min.
Above-mentioned Ligusticum wallichii essential oil composition has as the purposes of skin-care product additive.That is, according to the difference of use, this
During the Ligusticum wallichii essential oil composition of invention can be as additive addition skin care item, it is also possible to be used alone.Due to the Ligusticum wallichii essential oil
The preparation method of composition is simple to operate, and additive therefor is less, while skin care effect is played, can reduce to skin
Unnecessary injury.
It should be understood that the above-mentioned implementation method and following examples of present invention detailed description are merely to illustrate the present invention rather than limit
The scope of the present invention processed, some nonessential improvement and tune that those skilled in the art's the above of the invention is made
It is whole to belong to protection scope of the present invention.
Ligusticum wallichii essential oil composition of the present invention and its production and use is made furtherly with reference to specific embodiment
It is bright.
Embodiment 1-3：The preparation of Ligusticum wallichii essential oil composition
Listed corresponding weight weighs each component raw material according to the form below 1.
Proportioning (the unit of Ligusticum wallichii essential oil composition in the embodiment 1-3 of table 1：Part；Wherein, every part is 10g)
Wherein, Ligusticum wallichii essential oil is to make by oneself and use supercritical CO2It is obtained by extraction, specific method is：By Ligusticum chuanxiong Hort
Grain (crossing 30 mesh pharmacopeia sieve) loads supercritical CO2In extractor, it is 25MPa, control for 50 DEG C, extracting pressure to control extraction temperature
Each extraction time is 2h, and it is entrainer for 95% ethanol to use volumetric concentration；Peppermint oil is commercially available, meets national standard
GB/T26516-2011 essential oil quality criteria requirements；Glycerine is commercially available, meets national standard Q/HYH D34-2008 requirements.
The preparation method of above-described embodiment 1-3 is：
1) each component is weighed according to weight listed by table 1；
2) Ligusticum wallichii essential oil, peppermint oil, glycerine are sequentially placed into stirring container, are mixed at room temperature to full and uniform；
3) add preservative to continue to stir to fully fusion, after centrifugal treating (4000r/min) about 5min, take upper strata without miscellaneous
Matter aliquots obtain final product Ligusticum wallichii essential oil composition.
Embodiment 4-5：Strengthen the Ligusticum wallichii essential oil composition of whitening effect
Further to meet demand of the crowd to essential oil whitening, the present invention increased with U.S. on the basis of original formula
The essential oil of traditional Chinese medicine extract of white effect, strengthens whitening function, and listed corresponding weight weighs each group in specific according to the form below 2
Divide raw material.
Proportioning (the unit of Ligusticum wallichii essential oil composition in the embodiment 4-5 of table 2：Part；Wherein, every part is 10g)
Peppermint oil, root of Dahurain angelica essential oil, Radix Astragali essential oil, bighead atractylodes rhizome essential oil, Rosa Damascana be it is commercially available, meet standard GB/T/
T26516-2011 essential oil quality criteria requirements；Glycerine is commercially available, meets national standard Q/HYH D34-2008 requirements.
Preparation method is with embodiment 1-3.
Embodiment 6-7：Improve the Ligusticum wallichii essential oil composition of essential oil odor type
Further to meet demand of the crowd to essential oil whitening, the present invention is adjusted on the basis of original formula, fits
Answer different crowd to essential oil odor type requirement, listed corresponding weight weighs each component raw material in specific according to the form below 3.
Proportioning (the unit of Ligusticum wallichii essential oil composition in the embodiment 6-7 of table 3：Part；Wherein, every part is 10g)
Lavender, lemon, Rosa Damascana are commercially available, meet standard GB/T/T26516-2011 essential oil matter
The requirement of amount standard；Glycerine is commercially available, meets national standard Q/HYH D34-2008 requirements.
Preparation method is with embodiment 1-3.
Embodiment 8：Using Ligusticum wallichii essential oil composition obtained in embodiment 1 as skin-care product additive and its system of gel mask
It is standby.
Formula is as follows：0.5 part of xanthans, 0.5 part of locust bean gum, 0.3 part of monoglyceride, 0.03 part of EDTA, Phenoxyethanol 0.1
Part, 2 parts of propane diols, 0.5 part of sodium hyaluronate, 2 parts of Sodium Benzoate, 0.5 part of Ligusticum wallichii essential oil composition, 70 parts of distilled water.
Preparation method：The dry feedstocks such as sodium hyaluronate, Sodium Benzoate, xanthans, locust bean gum are weighed respectively by weight ratio
Component, is well mixed, and obtains A phases；Propane diols, monoglyceride, distilled water are weighed by weight ratio, and is stirred, obtain B
Phase；To the B phases being poured slowly into A phase powder in lasting stirring, at a temperature of 60~80 DEG C heat, continue stir to completely it is molten
Solution；After thing to be mixed cooling, stir while add Ligusticum wallichii essential oil composition, to fusion completely uniformly, and be put into centrifuge
In, after 4000r/min treatment 3min, obtain gel mask.
Embodiment 9：Ligusticum wallichii essential oil composition suppresses tyrosinase activity experiment
1) measuring principle
TYR generates DOPA in the presence of tyrosinase, and DOPA generates DOPA quinone under the further effect of enzyme,
Eventually pass series reaction generation melanin.Wherein DOPA quinone has maximum absorption band at 475nm wavelength, by the unit interval
It is interior, its absorbance is determined, the vigor size of enzyme in indirect reaction enzymic catalytic reaction system.DOPA quinone i.e. per minute is in 475nm ripples
Absorbance long increases by 0.001 and is defined as an enzyme activity unit.
2) preparation of solution
The preparation of the solution of phosphate-buffered salt：Weigh Na2HPO4·12H2O 8.775g, NaH2PO4·2H2O3.98g, uses
Deionized water fully dissolves constant volume in 250mL volumetric flasks, is configured to the phosphate buffer of the 0.2mol/L that pH value is 6.8.
The preparation of tyrosinase solution：It is that 200U/mL weighs a certain amount of tyrosinase according to enzyme activity unit, uses phosphoric acid
Salt buffer dissolves, and constant volume is stored in standby in refrigerator in the volumetric flask of required volume, you can.
The preparation of TYR solution：Precision weighs TYR 0.0272g, ultrasound pre-dispersed with phosphate buffer
30min, with phosphate buffer constant volume in 100mL volumetric flasks.
3) assay method
The corresponding TYR solution of T1, T2, T3, T4, PBS are accurately drawn with micropipettor by the volume of table 4 respectively
And the reaction solution of sample is respectively placed in 4 PE pipes, mix, then 37 DEG C of constant temperature 10min are separately added into 1mL's in T2, T4
Tyrosinase solution, reacts 10min, quick ultraviolet specrophotometer determined at 475nm its absorbance A T1, AT2, AT3,
AT4.The activity that sample suppresses tyrosinase is calculated as follows：
Inhibitory activity against tyrosinase=[1- (AT4-AT3)/(AT2-AT1)] × 100%.
Wherein, AT1：The absorbance for not being loaded product and not adding the reaction solution of tyrosinase solution to be measured at 475nm；
AT2：It is not loaded the absorbance that the reaction solution of product plus tyrosinase solution is measured at 475nm；
AT3：Sample-adding product and plus tyrosinase solution the absorbance that is measured at 475nm of reaction solution；
AT4：Sample-adding product and the absorbance for adding the reaction solution of tyrosinase solution to be measured at 475nm.
Wherein, the Ligusticum wallichii essential oil composition that the present embodiment sample is prepared using embodiment 3, control group is beautiful using having
The Rosa Damascana (commercially available, to meet standard GB/T/T26516-2011 essential oils quality criteria requirements) of white effect.
The Ligusticum wallichii essential oil composition of table 4 suppresses tyrosinase activity experiment reaction solution composition
4) measurement result
According to result of the test, 2 inhibitory activity against tyrosinase of Ligusticum wallichii essential oil composition of parallel determination, respectively
33.52%th, 34.21%, reference substance Rosa Damascana inhibitory activity against tyrosinase is only 21.35%, illustrates Ligusticum wallichii of the invention
Essential oil composition has significantly higher tyrosinase inhibition rate, shows that Ligusticum wallichii essential oil composition can be by suppressing tyrosinase
Activity, reduces the formation of melanin, and reaches whitening effect.
Embodiment 10：Ligusticum wallichii essential oil composition mosquito repellent is tested
The present embodiment invites 60 testing crews, and repelling effect tune on probation is carried out in July mosquito activity more dense days
Look into.
Application method：The Ligusticum wallichii essential oil composition 1~2 that embodiment 1 is prepared is dripped on skin, uniform application in
Easily by the position of bite by mosquitos.Using follow-up investigation after 1 month, 5 are the results are shown in Table.As can be known from the results, Ligusticum wallichii essential oil composition tool
There is certain repelling effect.
The repelling effect investigation of the Ligusticum wallichii essential oil composition of table 5
Remarks：
Repelling effect is good：After smearing, nothing stings thorn phenomenon；
Repelling effect is general：After smearing, mosquito quantity is significantly reduced, and mosquito stings thorn number of times and reduces；
Without repelling effect：After smearing, mosquito quantity, sting thorn phenomenon without change.
Embodiment 11：The whitening of Ligusticum wallichii essential oil composition, inducing resuscitation effect test
It is main with Ligusticum wallichii whitening, peppermint oil inducing resuscitation skin toner in Ligusticum wallichii essential oil composition, adjust the smell of Ligusticum wallichii essential oil.To test
Whitening, 2 effect effects of inducing resuscitation of Ligusticum wallichii essential oil composition are demonstrate,proved, invite several health volunteers to participate in the experiment of the present embodiment,
22~56 years old age, the more black or obscure women 50 of the colour of skin.The Ligusticum wallichii essential oil composition prepared using embodiment 1 is carried out
Experiment, it is sooner or later each 1 time daily.Application method：After clean skin, Ligusticum wallichii essential oil composition 2~4 is dropped in into the palm of the hand, massaged in face extremely
Absorb.
Using subject's result of the test is investigated after 1 month, concrete outcome is shown in Table 6.Result shows that Ligusticum wallichii essential oil composition has
Play the role of certain whitening, inducing resuscitation, and it is on probation after do not find obvious excitant and allergic phenomena.
Whitening, the inducing resuscitation result of the test of the Ligusticum wallichii essential oil composition of table 6
In sum, the invention provides a kind of Ligusticum wallichii essential oil composition with rhizoma chuanxiong volatile oil as main component and its system
Preparation Method and purposes, are a kind of simple to operate, raw material is natural and has no toxic side effect many effect essential oil products, additive therefor compared with
It is few, the unnecessary injury to skin can be reduced, with effective whitening, inducing resuscitation and mosquito repellent while skin care effect is played
Effect, can use alone or as additive, with Development volue, can enrich essential oil product market, meet consumer
Demand.
The invention is not limited in foregoing specific embodiment.The present invention is expanded to and any in this manual disclosed
New feature or any new combination, and disclose any new method or process the step of or any new combination.
Claims (10)
1. a kind of Ligusticum wallichii essential oil composition, it is characterised in that in parts by weight, the Ligusticum wallichii essential oil composition is included with the following group
Point：0.05~0.1 part of 45~55 parts of Ligusticum wallichii essential oil, 43~50 parts of glycerine, 5~10 parts of peppermint oil and preservative.
2. Ligusticum wallichii essential oil composition according to claim 1, it is characterised in that in parts by weight, the Ligusticum wallichii essential oil group
Compound includes following components：48~52 parts of Ligusticum wallichii essential oil, 44~46 parts of glycerine, 7~8 parts of peppermint oil and preservative 0.08~0.01
Part.
3. Ligusticum wallichii essential oil composition according to claim 1 and 2, it is characterised in that in parts by weight, the Ligusticum wallichii essential oil
Composition also includes 10~15 parts of 10~15 parts of root of Dahurain angelica essential oil and Radix Astragali essential oil.
4. Ligusticum wallichii essential oil composition according to claim 1 and 2, it is characterised in that in parts by weight, the Ligusticum wallichii essential oil
Composition also includes 8~15 parts of 10~15 parts of bighead atractylodes rhizome essential oil, 10~15 parts of root of Dahurain angelica essential oil and Rosa Damascana.
5. Ligusticum wallichii essential oil composition according to claim 1 and 2, it is characterised in that in parts by weight, the Ligusticum wallichii essential oil
Composition also includes 5~10 parts of 5~10 parts of Lavender, 10~15 parts of Rosa Damascana and lemon.
6. Ligusticum wallichii essential oil composition according to any one of claim 1 to 5, it is characterised in that the Ligusticum wallichii essential oil is adopted
Use supercritical CO2Extraction is obtained by extraction, the supercritical CO2Extraction is：Ligusticum chuanxiong Hort particle is loaded into supercritical CO2Extraction
Take and extracted in tank, the use of ethanol is entrainer, it is 20~30MPa for 50~60 DEG C, extracting pressure control extraction temperature, is controlled
The time that system is extracted every time is 1.5~2.5h, and the Ligusticum wallichii essential oil is finally obtained by extraction, wherein, the Ligusticum chuanxiong Hort particle energy
30~50 mesh pharmacopeia sieve was reached, the ethanol is ethanol that volumetric concentration is 90~95%.
7. Ligusticum wallichii essential oil composition according to any one of claim 1 to 5, it is characterised in that the preservative is by Buddhist nun
It is mixed with for one or more in pool that tortoise beetle ester, the golden ethyl ester of Nepal, Phenoxyethanol and methylisothiazolinone and obtains.
8. as any one of claim 1 to 7 Ligusticum wallichii essential oil composition preparation method, it is characterised in that the preparation
Method is comprised the following steps：
Each component is weighed according to weight part ratio；
Each component in addition to preservative is sequentially placed into stirring container, is mixed at room temperature to full and uniform；
Add preservative to continue to stir to fully fusion, upper strata free from admixture aliquots are taken after centrifugal treating and obtains the Ligusticum wallichii essence
Fluid composition.
9. according to claim 8 with the preparation method of Ligusticum wallichii essential oil composition, it is characterised in that control centrifugal treating rotating speed
It is 3000~5000r/min, the centrifugal treating time is 5~10min.
10. as any one of claim 1 to 7 Ligusticum wallichii essential oil composition as skin-care product additive purposes.
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| CN115040439B (en) * | 2022-06-30 | 2024-03-01 | 成都中医药大学 | Ligusticum wallichii essential oil skin care product and preparation method thereof |
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