CN108434309A - A kind of externally used paste and preparation method thereof for antipruritic anti-inflammatory after bite by mosquitos - Google Patents
A kind of externally used paste and preparation method thereof for antipruritic anti-inflammatory after bite by mosquitos Download PDFInfo
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- CN108434309A CN108434309A CN201810453648.2A CN201810453648A CN108434309A CN 108434309 A CN108434309 A CN 108434309A CN 201810453648 A CN201810453648 A CN 201810453648A CN 108434309 A CN108434309 A CN 108434309A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The invention belongs to externally used paste fields, and in particular to a kind of externally used paste and preparation method thereof for antipruritic anti-inflammatory after bite by mosquitos.On the basis of the total weight of the externally used paste, which contains following components by weight：Garlic juice 10% 50%；Beeswax 10% 50%；Edible vegetable oil 20% 60%；Plants essential oil 1% 10%；Auxiliary agent 1% 5%；The auxiliary agent is at least one of antioxidant, stabilizer and emulsifier.The externally used paste of the present invention can quickly and effectively alleviate the symptoms such as sufferings, redness, inflammation after bite by mosquitos, have safe without toxic side effect, it is non-stimulated to skin, without bad smell, use feeling is good, easy to carry the features such as.
Description
Technical field
The invention belongs to externally used paste fields, more particularly, to a kind of external application for antipruritic anti-inflammatory after bite by mosquitos
Paste and preparation method thereof.
Background technology
In every spring and summer season, as temperature increases, mosquito largely multiplies, and people are frequently subjected to biting for mosquito.The skin of people
Skin is by after bite by mosquitos, it will usually cause the symptoms such as local skin itching, redness, inflammation.It can be secreted when bite by mosquitos human body
A kind of anti-coagulants, induction human immune system discharge a kind of chemical substance being referred to as histamine.Histamine is combined with histamine receptor, can
To cause skin heart, telangiectasis, permeability to increase, thin vessels exudation, hyperemia causes erythema.Meanwhile histamine can pierce
Swash cutaneous nerve end slightly, generates strong sufferings sense.
Bite by mosquitos endangers bigger for children.The skin of children is more delicate, sensitive, and protection mechanism development is not perfect.
For children after by bite by mosquitos, general is difficult to endure its caused sufferings to feel, can usually scratch skin, cause skin epidermis by
Damage, impaired place are easy to be infected by bacterial, and further inflammation is suppurated.The children of certain allergic constitutions can cause skin after being bitten
Skin allergy induces dermatitis fash.
It is mainly cooling ointment and essential wind oil to be usually used in the product of bite by mosquitos at present.The main component of cooling ointment and essential wind oil
For menthol, camphor, eucalyptus oil and eugenol etc., when menthol and camphor preparations are applied on skin, skin, mucous membrane can be made
Frigidoreceptor generates sense of cold reflection, and skin, mucous membrane vessel retraction, camphor is caused to have antipruritic, analgesic drawn game anaesthetic effect,
Menthol, camphor, eucalyptus oil, eugenol etc. also have strong expulsion to act on mosquito.Both products are mainly by skin
Stimulation, disperse the brain of people to the feeling itched, red swelling of the skin caused by bite by mosquitos, inflammation etc. cannot be treated completely.
In addition both products have stronger penetrating odor and skin irritation, it is impossible to be used in the sensitive part of children and human body.Have
Some drugs are also commonly used for bite by mosquitos, such as Compound Dexamethasone Acetate, new skin snake-fat ointment, sting the not happy antiseptic of oxygen husband, gentian violet.But this
A little drugs do not have positive effect, some also to generate certain side effect based on anti-inflammatory, for the toxic removing of itching of disappearing.
In addition, civil folk prescription has garlic for treating bite by mosquitos, with tableted uncooked garlic at by bite by mosquitos
It embrocates repeatedly, there is apparent analgesic, antipruritic, antiinflammation.In view of uncooked garlic is inconvenient to carry and uses, Zhangye medicine height etc.
Uncooked garlic is broken into paste by junior college Jiang Haiying etc., the materials such as atoleine and vaseline is added, garlic (soft) has been made
Cream, and observe and compare the effect of garlic (soft) cream and uncooked garlic are to adult and child's bite by mosquitos.Clinical trial results show
With uncooked garlic, without significant difference, bite by mosquitos can be effectively relieved in the effect of garlic (soft) cream treatment adult and child's bite by mosquitos
The symptoms such as caused redness, sufferings, and curative effect is stablized, it is small to skin irritation, it is easy to use.
According to analyses such as Jiang Haiying, the principle of Garlic in Treatment bite by mosquitos may be：The sulfur-bearing organic compound contained in garlic
Object, vitamin and mineral alleviate through a variety of ways and treat bite by mosquitos induction histamine release caused by redness, itch pain
Etc. symptoms；Allicin has broad-spectrum antiseptic antiinflammation, can prevent and treat the secondary infection caused by bite by mosquitos and scratching；
Garlic contains trace elements of selenium, and selenium is the important component of glutathione peroxidase, can be with specific catalytic reduced form gluathione
Peptide and peroxide reactions remove the toxin secreted when bite by mosquitos.
But according to garlic cream made of the institutes such as Jiang Haiying presentation method, due to containing garlic residue, product quality is thicker
It is rough, and have very strong garlic flavour, it is unfavorable for people and receives and use.
Invention content
The purpose of the present invention is for currently without this problem of the product dedicated for antipruritic anti-inflammatory after bite by mosquitos, carry
For a kind of external preparation that can quickly and effectively alleviate the symptoms such as sufferings, redness, inflammation after bite by mosquitos, this preparation has peace
Completely without toxic side effect, it is non-stimulated to skin, without bad smell, use feeling is good, easy to carry the features such as.
Garlic cream is made as primary raw material using allicin (powder), mashed garlic (paste), garlic juice respectively in the present inventor,
It is used to treat bite by mosquitos experiment together with uncooked garlic slice, as a result, it has been found that, using mashed garlic (paste), garlic juice as made of raw material
Garlic cream and uncooked garlic slice, the symptoms such as sufferings, redness, inflammation after bite by mosquitos can be effectively relieved, especially with garlic juice
Significantly, quickly for garlic cream therapeutic effect made of raw material, it is that garlic cream made of raw material is only capable of with allicin (powder)
Play the role of anti-inflammatory, is unable to Quick itch stopping detumescence.Result, it is believed that the garlic cream used in the prior art, active ingredient master
It is present in garlic juice, is based on this important discovery, completes the present invention.
The present invention provides a kind of externally used paste for antipruritic anti-inflammatory after bite by mosquitos, with the total weight of the externally used paste
On the basis of, which contains following components by weight：
Garlic juice 10%-50%；Beeswax 10%-50%；Edible vegetable oil 20%-60%；Plants essential oil 1%-10%；It helps
Agent 1%-5%；
The auxiliary agent is at least one of antioxidant, stabilizer and emulsifier.
Preferably, on the basis of the total weight of the externally used paste, which contains following components by weight：
Garlic juice 25%-35%；Beeswax 25%-35%；Edible vegetable oil 35%-45%；Plants essential oil 4%-6%；Emulsifier
0.5%-2%；Stabilizer 0.5%-2%；Antioxidant 0.1%-1%.
In the present invention, it is preferable to use fresh garlic juice for the garlic juice.The fresh garlic juice refers to 24 hours after squeezing out
Within garlic juice.Garlic juice can be made by the various methods of this field routine, for example, selecting fresh or dry without lesion
Garlic, preferably purple garlic or single clove garlic are peelled off crust, are squeezed by hand or with juice extractor, filtered.If do not used immediately,
Gained garlic juice need to be placed on refrigeration in refrigerator, be finished in best 24 hours.
Since inventive article is used for human skin external application, the beeswax is preferably food grade beeswax.
According to the present invention, the edible vegetable oil can be soybean oil, peanut oil, sunflower oil, olive oil and sesame oil
At least one of.Consider that the edible vegetable oil is preferably virgin oil for skin safe and use feeling.
According to the present invention, the plants essential oil can be Lavender, Rosa Damascana, oil of Cymbopogon winterianus, tea tree ethereal oil, pine
Set essential oil, orange essential oil, Peppermint essential oil or schizonepeta essential oil.After plants essential oil is added, the externally used paste has more pleasant gas
Taste.
According to the present invention, the auxiliary agent is for improving externally used paste stability and improving the various additions of use feeling
Agent.The antioxidant is preferably one or more of vitamin, tea polyphenols, carrotene and citric acid, the vitamin packet
It includes but is not limited to vitamin B1,6, vitamin E, vitamin C.The dosage of the vitamin is preferably 0.05-0.5%, the lemon
The dosage of acid is preferably 0.1-1%.
The stabilizer is preferably cyclodextrin and calcium chloride.
The emulsifier can be glycerin monostearate, sorbitan monooleate, sorbitan trioleate,
Sorbitan monopalmitate, propylene glycol monostearate, hydroxylated lanolin, diethylene glycol aliphatic ester, propylene glycol list
One or more of laurate and lecithin.
The present invention also provides the preparation method of above-mentioned externally used paste, this method includes：
(1) by beeswax heating and melting；
(2) edible vegetable oil, garlic juice and auxiliary agent is added, stirring makes uniform emulsion liquid；
(3) plants essential oil is added, stirs evenly；
(4) step (3) acquired solution is dispensed, stands cooling, makes its solidification.
The heating and melting temperature of the beeswax is usually 85-95 DEG C.
The application method of externally used paste of the present invention is as follows：After bite by mosquitos, take paste of the present invention anti-in affected part a little
Overcoating is wiped, and can significantly alleviate sufferings feeling in 1-3 minutes, and prevent or alleviate the hair of the symptoms such as follow-up red swelling of the skin, inflammation
It is raw.
The externally used paste of the present invention has the following advantages that：
(1) safe.The present invention is using Natural Foods grade raw material such as fresh garlic juice, beeswax, vegetable oil as master
Raw material, prepared paste is wanted to be highly safe, it is nontoxic, non-stimulated, it is suitble to the various people including children to make
With.
(2) it is used after bite by mosquitos, can quickly go analgesic of itching, the symptoms such as red swelling of the skin, inflammation are effectively relieved.The present invention
Other than using the function of analgesic of going to itch possessed by garlic, antibacterial anti-inflammatory, a large amount of natural activities contained in beeswax are also utilized
N-octacosanol in ingredient and its physiological function, such as beeswax, which has, promotes skin blood cycle, activating cell, antibacterial anti-inflammatory
Function.
(3) to squeeze garlic juice instead of mashed garlic as main function ingredient, keep product quality finer and smoother, quality is more
Stablize.We have discovered that the curative effect identical as Bulbus Allii paste, uncooked garlic can be obtained with squeezing garlic juice.Using garlic juice as original
Material, can significantly improve the quality of product.
(4) beeswax and vegetable oil selected by are lipstick and lipstick common used material, preserving moisture and protecting skin good to skin compatibility, no
It is greasy.
(5) it selects the plants essential oil with fragrance to be reconciled, masks the bad smell of garlic.Product fragrance is preferably
People easily receives for various people.
(6) since the present invention has very strong antibacterial and anti-inflammation functions, in addition to it can be used for bite by mosquitos, it may also be used for prevention
The above made paste is applied to affected part repeatedly by other scytitis (such as tinea pedis, eczema, acne, prickly heat, solar dermatitis)
It embrocates, itching, antibacterial anti-inflammatory can be effectively relieved.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Description of the drawings
Exemplary embodiment of the invention is described in more detail in conjunction with the accompanying drawings.
Fig. 1 is the outside drawing of the externally used paste of the present invention.
Fig. 2 is the using renderings of the externally used paste of the present invention.
Specific implementation mode
The preferred embodiment of the present invention is described in more detail below.Although the following describe the preferred implementations of the present invention
Mode, however, it is to be appreciated that may be realized in various forms the present invention without should be limited by embodiments set forth herein.
Embodiment 1
The externally used paste is made of following parts by weight raw material：
The formula of ointment preparation：Fresh garlic juice 30%；Edible beeswax 30%；Virgin oil 33%；Oil of Cymbopogon winterianus
5%；Vitamin E 0.1%, citric acid 1%；Cyclodextrin 1%.
Preparation method：
(1) 30g beeswaxs are put into glass container, are placed in heating (85 DEG C -95 DEG C) in water-bath, stirring keeps beeswax complete
Melt.
(2) 33g olive oil, 30g garlic juices, 100mg vitamin Es, 1g citric acids is added, 1g cyclodextrin is stirred and is allowed into
For uniform emulsion liquid.
(3) it is eventually adding 5g oil of Cymbopogon winterianus, is stirred evenly.
(4) above-mentioned solution is dispensed into ready capsule, stands cooling, makes its solidification, as shown in Figure 1.
Embodiment 2
The externally used paste is made of following parts by weight raw material：
The formula of ointment preparation：Fresh garlic juice 30%；Edible beeswax 30%；Soybean oil 33%；Tea tree ethereal oil 5%；Dimension
Raw element E 0.1%, citric acid 1%；Cyclodextrin 1%.
Preparation method：
(1) it will be put into glass container with 30g beeswaxs, and be placed in heating (85 DEG C -95 DEG C) in water-bath, stirring keeps beeswax complete
It is complete to melt.
(2) 33g soybean oils, 30g garlic juices, 100mg vitamin Es, 1g citric acids is added, 1g cyclodextrin is stirred and is allowed into
For uniform emulsion liquid.
(3) 5g tea tree ethereal oils are eventually adding, are stirred evenly.
(4) above-mentioned solution is dispensed into ready capsule, stands cooling, makes its solidification.
Test case 1
To investigate the effect of paste of the present invention is to bite by mosquitos and safety, 80 patients by bite by mosquitos are selected, are made
Paste embrocates affected part made from embodiment 1, investigates and count the alleviation situation of the symptoms such as affected part sufferings, redness.
As a result as shown in Table 1 and Table 2.
1. paste of the present invention of table Tone between the Huan solutions Shi of sufferings symptom after bite by mosquitos is looked into [n (%)]
| Tone looks into number | <3 minutes (antipruritic at once) | 3-10 minutes | There is no positive effect |
| 80 | 56 (70.0%) | 18 (22.5%) | 6 (7.5%) |
2. paste of the present invention of table Tone between the Huan solutions Shi of red and swollen symptom after bite by mosquitos is looked into [n (%)]
| Tone looks into number | <30 minutes | - 6 hours 30 minutes | More than 6 hours |
| 80 | 22 (27.5%) | 50 (62.5%) | 8 (10%) |
Test case 2
Further to investigate the effect of paste of the present invention is to children's bite by mosquitos, by negotiating with teacher and parents,
50 children are selected in local kindergarten, then carry out experiment under the assistance of teacher and parent.In 50 children, wherein 30
Name immediately carries out affected part using 1 paste of embodiment after bite by mosquitos to embrocate processing, and in addition 20 are not done after bite by mosquitos
Any processing observes and records the remission status such as affected part sufferings, redness.The results are shown in Table 3.
The effect of 3. paste of the present invention of table is to children's bite by mosquitos investigates [n (%)]
The externally used paste of the present invention can quickly go analgesic of itching it can be seen from test case 1 and 2, and it is red that skin is effectively relieved
The symptoms such as swollen, inflammation.
Various embodiments of the present invention are described above, above description is exemplary, and non-exclusive, and
It is not limited to disclosed each embodiment.Without departing from the scope and spirit of illustrated each embodiment, for this skill
Many modifications and changes will be apparent from for the those of ordinary skill in art field.
Claims (10)
1. a kind of externally used paste for antipruritic anti-inflammatory after bite by mosquitos, which is characterized in that with the total weight of the externally used paste
On the basis of, which contains following components by weight：
Garlic juice 10%-50%；Beeswax 10%-50%；Edible vegetable oil 20%-60%；Plants essential oil 1%-10%；Auxiliary agent
1%-5%；
The auxiliary agent is at least one of antioxidant, stabilizer and emulsifier.
2. externally used paste according to claim 1, wherein on the basis of the total weight of the externally used paste, the external plaster
Agent contains following components by weight：Garlic juice 25%-35%；Beeswax 25%-35%；Edible vegetable oil 35%-45%；It plants
Object essential oil 4%-6%；Emulsifier 0.5%-2%；Stabilizer 0.5%-2%；Antioxidant 0.1%-1%.
3. externally used paste according to claim 1 or 2, wherein the garlic juice is fresh garlic juice.
4. externally used paste according to claim 1 or 2, wherein the beeswax is food grade beeswax.
5. externally used paste according to claim 1 or 2, wherein the edible vegetable oil is soybean oil, peanut oil, sunflower
At least one of seed oil, olive oil and sesame oil.
6. externally used paste according to claim 1 or 2, wherein the plants essential oil be Lavender, Rosa Damascana,
Oil of Cymbopogon winterianus, tea tree ethereal oil, pine tree essence oil, orange essential oil, Peppermint essential oil or schizonepeta essential oil.
7. externally used paste according to claim 1 or 2, wherein the antioxidant is vitamin, tea polyphenols, carrotene
One or more of with citric acid.
8. externally used paste according to claim 1 or 2, wherein the stabilizer is cyclodextrin and calcium chloride.
9. externally used paste according to claim 1 or 2, wherein the emulsifier is glycerin monostearate, Sorbitan
Alcohol monoleate, sorbitan trioleate, sorbitan monopalmitate, propylene glycol monostearate, hydroxylating sheep
One or more of hair fat, diethylene glycol aliphatic ester, propylene glycol monolaurate and lecithin.
10. the preparation method of the externally used paste described in any one of claim 1-9, which is characterized in that this method includes：
(1) by beeswax heating and melting；
(2) edible vegetable oil, garlic juice and auxiliary agent is added, stirring makes uniform emulsion liquid；
(3) plants essential oil is added, stirs evenly；
(4) step (3) acquired solution is dispensed, stands cooling, makes its solidification.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810453648.2A CN108434309A (en) | 2018-05-14 | 2018-05-14 | A kind of externally used paste and preparation method thereof for antipruritic anti-inflammatory after bite by mosquitos |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810453648.2A CN108434309A (en) | 2018-05-14 | 2018-05-14 | A kind of externally used paste and preparation method thereof for antipruritic anti-inflammatory after bite by mosquitos |
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| CN108434309A true CN108434309A (en) | 2018-08-24 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2784949A1 (en) * | 2019-03-28 | 2020-10-02 | Costa Josep Maria Sirvent | Cosmetic product to avoid scars. (Machine-translation by Google Translate, not legally binding) |
| CN114129651A (en) * | 2021-12-10 | 2022-03-04 | 南京爱凯润生物科技有限公司 | Itching relieving ointment for mosquito bites and preparation method thereof |
-
2018
- 2018-05-14 CN CN201810453648.2A patent/CN108434309A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2784949A1 (en) * | 2019-03-28 | 2020-10-02 | Costa Josep Maria Sirvent | Cosmetic product to avoid scars. (Machine-translation by Google Translate, not legally binding) |
| CN114129651A (en) * | 2021-12-10 | 2022-03-04 | 南京爱凯润生物科技有限公司 | Itching relieving ointment for mosquito bites and preparation method thereof |
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Application publication date: 20180824 |
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