CN101336966A - Osmidrosis dispelling liniment containing natural essential oil of Zingiber corallinum Hance - Google Patents
Osmidrosis dispelling liniment containing natural essential oil of Zingiber corallinum Hance Download PDFInfo
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- CN101336966A CN101336966A CNA2008100701171A CN200810070117A CN101336966A CN 101336966 A CN101336966 A CN 101336966A CN A2008100701171 A CNA2008100701171 A CN A2008100701171A CN 200810070117 A CN200810070117 A CN 200810070117A CN 101336966 A CN101336966 A CN 101336966A
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- supercritical
- extract
- liniment
- ethanol
- polyoxyethylene
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- 239000000865 liniment Substances 0.000 title claims abstract description 25
- 229940040145 liniment Drugs 0.000 title claims abstract description 25
- 241000146412 Zingiber corallinum Species 0.000 title claims abstract description 7
- 239000000341 volatile oil Substances 0.000 title claims abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 54
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 52
- -1 polyoxyethylene Polymers 0.000 claims abstract description 18
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 17
- 239000004359 castor oil Substances 0.000 claims abstract description 17
- 235000019438 castor oil Nutrition 0.000 claims abstract description 17
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 17
- 229940118827 zinc phenolsulfonate Drugs 0.000 claims abstract description 17
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 claims abstract description 17
- 239000008367 deionised water Substances 0.000 claims abstract description 16
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241000628997 Flos Species 0.000 claims description 34
- 239000003921 oil Substances 0.000 claims description 20
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 16
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 16
- 235000011152 sodium sulphate Nutrition 0.000 claims description 16
- 230000001476 alcoholic effect Effects 0.000 claims description 10
- 239000007791 liquid phase Substances 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
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- 230000002588 toxic effect Effects 0.000 abstract description 4
- 230000002411 adverse Effects 0.000 abstract 2
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 abstract 1
- 240000005250 Chrysanthemum indicum Species 0.000 abstract 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 244000223014 Syzygium aromaticum Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
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- 230000000857 drug effect Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
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- 229940051841 polyoxyethylene ether Drugs 0.000 abstract 1
- 229920000056 polyoxyethylene ether Polymers 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
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- 230000001225 therapeutic effect Effects 0.000 abstract 1
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- 206010055000 Bromhidrosis Diseases 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 239000003814 drug Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 5
- 208000003251 Pruritus Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
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- 239000002671 adjuvant Substances 0.000 description 2
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- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 229960004011 methenamine Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 239000003860 topical agent Substances 0.000 description 2
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010005913 Body tinea Diseases 0.000 description 1
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- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
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- 206010061218 Inflammation Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 210000000040 apocrine gland Anatomy 0.000 description 1
- 230000036773 apocrine secretion Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
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- 206010013023 diphtheria Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
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- 206010040882 skin lesion Diseases 0.000 description 1
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- DSNIKOZTDZBWKD-XMNJDQQWSA-N yejuhua lactone Chemical compound O([C@H]1C2C[C@H]([C@@](C3C1C(=CC3)C)(C)O)OC(=O)C)C(=O)C2(C1(C)C=C2)CC22C1[C@H]1OC(=O)C(=C)C1CC[C@@]2(C)O DSNIKOZTDZBWKD-XMNJDQQWSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention provides a liniment with good treatment effect on hircismus, stable performance and no toxic and adverse effects, which is prepared from the following components of (by weight parts): Zingiber corallinum essential oil 0.5-5.0, Chrysanthemum indicum flower supercritical CO2 extract 0.0-2.0, Eugenia caryophyllata supercritical CO2 extract 0.3-3.0, zinc phenolsulfonate 2.0-8.0, 4-chloro-3,5-dimethylphenol 0.5-4.0, propylene glycol 1.0-8.0, ethanol 20.0-50.0, polyoxyethylene (40) hydrogenated castor oil 0.1-2.0, sodium fatty alcohol polyoxyethylene ether sulfate 0.1-3.0, essence 0.1-0.5 and deionized water 40.0-60.0 by the steps of homogenizing and filtering. The product has effects of sterilizing, deodorizing, suppressing sweating, moistening skin, and perfuming; and is a multifunctional deodorant liniment. The product is mild; and has the advantages of no irritation, no toxic and adverse effects, quick action, good therapeutic effect, convenient service, long-lasting drug effect, and no contamination of clothes.
Description
Technical field
The present invention relates to a kind of external liniment of the bromhidrosis of dispelling, particularly a kind of is the osmidrosis dispelling liniment of main active with the Rhizoma Zingiberis corallini quintessence oil.
Background technology
Bromhidrosis is one of common illness of human body, is the stench that the perspiration of apocrine secretion of human body axillary fossa produces after by bacterial decomposition.Prior art treatment bromhidrosis mainly contains topical agent method, drugs local injection method and surgical excision.Drugs local injection method and surgical excision belong to the treatment means that wound property is arranged, and are not generally accepted by people.The topical agent method has dosage forms such as liquid, powder body and mastic, and effect has nothing in common with each other.The liniment for the treatment of bromhidrosis in the market is a lot, all has different shortcomings, and the effective drug duration that has is short, has only about 12-24 hour; What have mainly contains chemical raw material, and toxic and side effects is bigger, and the patient applies ointment that back skin erythra occurs, scratches where it itches, redness even inflammation; What have mainly contains flavoring agent, can only hide stink, relief of symptoms; What have also can pollution clothes.Over past ten years, the technological invention of external curing bromhidrosis is a lot.Existing 40 multinomial patent applications Chinese invention patent.These patents suppress to be decomposed the antibacterial that perspiration produces stink with antimicrobial drug, use Antiperspirant to reduce and perspire, and alleviate the stink of health with aromatic, and effect is not desirable especially.Chinese patent ZL03119412.5 " hexamethylenamine external spraying agent and preparation method " is mainly by suppressing the purpose that sweat secretion reaches the bromhidrosis of dispelling, effect better but hexamethylenamine is bigger to the zest of skin, usually cause skin allergy, skin pruritus, redness even fester etc.
Summary of the invention
It is better to the purpose of this invention is to provide a kind of bromhidrosis effect of dispelling, and has no side effect the osmidrosis dispelling liniment of stable performance.
The technical scheme that adopts is as follows: this osmidrosis dispelling liniment is a kind of to be main active with the natural Zingiber corallinum Hance essential oil, it is characterized in that preparing as follows:
(1) takes by weighing each component by following mass fraction: Rhizoma Zingiberis corallini quintessence oil 0.5～5.0, Flos Chrysanthemi Indici supercritical CO
2Extract 0.2～2.0, the Flos Caryophylli supercritical CO
2Extract 0.3～3.0, zinc phenolsulfonate 2.0～8.0, chlorxylone 0.5～4.0, propylene glycol 1.0～8.0, ethanol 20.0～50.0, polyoxyethylene (40) castor oil hydrogenated 0.1～2.0, polyoxyethylenated alcohol sodium sulfate 0.1～3.0, essence 0.1～0.5, deionized water 40.0～60.0.
(2) earlier with Rhizoma Zingiberis corallini quintessence oil, Flos Chrysanthemi Indici supercritical CO
2Extract, Flos Caryophylli supercritical C0
2Extract, chlorxylone, polyoxyethylenated alcohol sodium sulfate, polyoxyethylene (40) castor oil hydrogenated are dissolved in the mixed solution of ethanol and propylene glycol at normal temperatures, then zinc phenolsulfonate is dissolved in the deionized water, at last water-soluble liquid phase is inserted alcoholic solution mutually in, add essence, homogenizing 5～30 minutes filters promptly.
Wherein described each component of step (1) preferably proportioning be: Rhizoma Zingiberis corallini quintessence oil 1～4.0, Flos Chrysanthemi Indici supercritical CO
2Extract 0.8～1.5, the Flos Caryophylli supercritical CO
2Extract 1.0～2.0, zinc phenolsulfonate 4.0～6.0, chlorxylone 1.0～2.0, propylene glycol 2.0～6.0, ethanol 25.0～45.0, polyoxyethylene (40) castor oil hydrogenated 0.5～1.5, polyoxyethylenated alcohol sodium sulfate 0.5～2.5, essence 0.2～0.4, deionized water 45.0～55.0.
The active component of osmidrosis dispelling liniment of the present invention is Rhizoma Zingiberis corallini quintessence oil, Flos Chrysanthemi Indici supercritical CO
2Extract, Flos Caryophylli supercritical CO
2Extract, chlorxylone and zinc phenolsulfonate, polyoxyethylene (40) castor oil hydrogenated, polyoxyethylenated alcohol sodium sulfate are that AES, essence are adjuvant, and propylene glycol, ethanol, deionized water are solvent.Various components all can be buied from market or be adopted prior art to make.
Rhizoma Zingiberis corallini quintessence oil is the effective ingredient of Rhizoma Zingiberis corallini, be a kind of good natural antibacterial agent and antifungal, can treat fungus-caused tinea corporis, tinea cruris, various dermatosiss such as seborrheic dermatitis. Rhizoma Zingiberis corallini quintessence oil to 28 strains in the penicillin-fast golden Portugal of the antibacterial activity 30 strains bacterium of the penicillin-fast golden Portugal of the 30 strains bacterium of clinical AD skin lesion surface isolation to the Rhizoma Zingiberis corallini quintessence oil sensitivity, responsive rate 93.3%.Rhizoma Zingiberis corallini quintessence oil contains terpinene-4-alcohol, has antibiotic, antifungal, heat-clearing and toxic substances removing, sterilizing and itch-relieving, anti-inflammatory analgetic detumescence, and skin diseases such as various tinea diseases, acne, skin itching, yellowish-brown class are suffered from prophylactic-therapeutic effect.Can effectively kill and suppress to decompose the various antibacterials of perspiration generation stink.
The Flos Chrysanthemi Indici supercritical CO
2Extract contains various active compositions such as alantol, yejuhua lactone, artoglasin, chrysanthanone, trace element, it is a kind of efficiency natural antibacterial, to staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi, influenza virus, all kill and inhibitory action.Functions such as antiinflammatory, antioxidation, analgesia, antieczematic, skin pruritus are arranged.Smelly antibacterial is produced in the oxter very strong killing action is arranged.
The Flos Caryophylli supercritical CO
2Extract is to use supercritical CO
2Technology extraction Flos Caryophylli alabastrum and the extract that obtains.Contain eugenol, β-caryophyllene etc., have the special aroma of Flos Caryophylli.Can treat tinea disease, halitosis, toothache, neuralgia, bromhidrosis is also had the obvious suppression effect.Its fragrance has the effect of doing of the bromhidrosis covered simultaneously.
The clean new PX of chlorxylone trade name phenol is a kind of good antibacterial and antiseptic, is widely used in the operation sterilization of hospital, and the armarium sterilization also can be made antibiotic anticorrosion raw materials such as disinfectant, handwashing liquid, shampoo, textile, coating, leather.Can kill and suppress to decompose the antibacterial of perspiration, most of Gram-positive and negative bacterium and mycete are had fabulous killing effect.
Zinc phenolsulfonate is a kind of antiperspirant, and protein is had cohesion, can enable the apocrine gland progressively atrophy in evening of secretion abnormal flavour, hinders the circulation of perspiration, suppresses perspire, thereby reaches the purpose that reduces the sweat secretion amount.In addition, also have certain sterilization, bacteria resistance function.The present invention makes the bromhidrosis effect of dispelling be fully protected under the effect of these active component, has especially used natural components such as Rhizoma Zingiberis corallini quintessence oil, and product is had no side effect.
In the adjuvant, polyoxyethylene (40) castor oil hydrogenated, AES (polyoxyethylenated alcohol sodium sulfate) have solubilising and increase the effect of drug osmotic, can improve product stability and heighten the effect of a treatment.Propylene glycol, ethanol are mainly as solvent, and propylene glycol strengthens the liniment screening characteristics in addition.Essence plays to be composed fragrant and but smelly effect.
Osmidrosis dispelling liniment of the present invention can adopt puts the bottle packing on the skin, also can adopt spray bottle packing.When the bottle packing was put in use on the skin, on medical absorbent cotton, the dab axillary fossa was put the back on the skin and got final product deodorization in several minutes with medicine liquid droplet, and is better with the effect of applying ointment after taking a shower especially, can put on the skin in 6～10 days 1 time at every interval.When using spray bottle packing, spray is directly aimed at the affected part spray delivery get final product.
This osmidrosis dispelling liniment has carried out clinical practice to 100 routine patients, and in the 1～February of following operating period of prerequisite of stopping using the other drug treatment, effective percentage reaches 92%, and in 2～April of operating period, effective percentage reaches 100%.
The beneficial effect of deodorant liniment of the present invention is: adopt the natural disinfection antibacterial natural Zingiber corallinum Hance essential oil of human temperature and safety functional active components as deodorant, avoided using traditional, to the chemosynthesis antibacterial of human body toxic side effect.Product has effects such as sterilization deodorant, hidroschesis, skin moistening, tax perfume (or spice), is a kind of multi-functional deodorant liniment.The product gentleness, nonirritant has no side effect, and instant effect is evident in efficacy, and is easy to use, lasting medicine, not pollution clothes.
Specific embodiment (totally 8 examples)
Embodiment 1
Get Rhizoma Zingiberis corallini quintessence oil 3.0kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 2.0kg, the Flos Caryophylli supercritical CO
2Extract 0.3kg, chlorxylone 1.0kg, AES (polyoxyethylenated alcohol sodium sulfate) 2.0kg, polyoxyethylene (40) castor oil hydrogenated 1.0kg is dissolved in the mixed solution of 40.0kg ethanol and 5.0kg propylene glycol at normal temperatures, zinc phenolsulfonate 3.0kg is dissolved in the 42.6kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.1kg, homogenizing 10min, filter, promptly get this liniment.
Embodiment 2:
Get Rhizoma Zingiberis corallini quintessence oil 4.0kg, Flos Chrysanthemi Indici supercritical CO
2Extract 1.0kg, Flos Caryophylli supercritical CO
2Extract 0.4kg, chlorxylone 1.5kg, AES (polyoxyethylenated alcohol sodium sulfate) 3.0kg, polyoxyethylene (40) castor oil hydrogenated 0.5kg are dissolved in the mixed solution of 42.0kg ethanol and 5.0kg propylene glycol at normal temperatures, zinc phenolsulfonate 2.0kg is dissolved in the 40.5kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.1kg, homogenizing 15min filters and promptly gets this liniment.
Embodiment 3:
Get Rhizoma Zingiberis corallini quintessence oil 4.5kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 1.5kg, the Flos Caryophylli supercritical CO
2Extract 0.3kg,, chlorxylone 1.0kg, AES (polyoxyethylenated alcohol sodium sulfate) 3.0kg, polyoxyethylene (40) castor oil hydrogenated 0.4kg be dissolved in the mixed solution of 38.0kg ethanol and 6.0kg propylene glycol at normal temperatures, zinc phenolsulfonate 4.0kg is dissolved in the 41.2kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.1kg, homogenizing 18min filters and promptly gets this liniment.
Embodiment 4
Get Rhizoma Zingiberis corallini quintessence oil 0.5kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 0.2kg, the Flos Caryophylli supercritical CO
2Extract 0.3kg, chlorxylone 0.5kg, AES (polyoxyethylenated alcohol sodium sulfate) 0.1kg, polyoxyethylene (40) castor oil hydrogenated 0.1kg are dissolved in the mixed solution of 20.0kg ethanol and 1kg propylene glycol at normal temperatures, zinc phenolsulfonate 2.0kg is dissolved in the 40.0kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.1kg, homogenizing 30min filters and promptly gets this liniment.
Embodiment 5
Get Rhizoma Zingiberis corallini quintessence oil 5.0kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 2.0kg, the Flos Caryophylli supercritical CO
2Extract 3.0kg, chlorxylone 4.0kg, AES (polyoxyethylenated alcohol sodium sulfate) 3.0kg, polyoxyethylene (40) castor oil hydrogenated 2kg are dissolved in the mixed solution of 50.0kg ethanol and 8.0kg propylene glycol at normal temperatures, zinc phenolsulfonate 8.0kg is dissolved in the 60kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.5kg, homogenizing 5min filters and promptly gets this liniment.
Embodiment 6
Get Rhizoma Zingiberis corallini quintessence oil 1kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 0.8kg, the Flos Caryophylli supercritical CO
2Extract 1kg, chlorxylone 1.0kg, AES (polyoxyethylenated alcohol sodium sulfate) 0.5kg, polyoxyethylene (40) castor oil hydrogenated 0.5kg are dissolved in the mixed solution of 25.0kg ethanol and 2.0kg propylene glycol at normal temperatures, zinc phenolsulfonate 4.0kg is dissolved in the 45kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.2kg, homogenizing 20min filters and promptly gets this liniment.
Embodiment 7
Get Rhizoma Zingiberis corallini quintessence oil 4.0kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 1.5kg, the Flos Caryophylli supercritical CO
2Extract 2kg, chlorxylone 2.0kg, AES (polyoxyethylenated alcohol sodium sulfate) 2.5kg, polyoxyethylene (40) castor oil hydrogenated 1.5kg are dissolved in the mixed solution of 45.0kg ethanol and 6.0kg propylene glycol at normal temperatures, zinc phenolsulfonate 6.0kg is dissolved in the 55kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.4kg, homogenizing 25min filters and promptly gets this liniment.
Embodiment 8
Get Rhizoma Zingiberis corallini quintessence oil 3kg, the Flos Chrysanthemi Indici supercritical CO
2Extract 1.5kg, the Flos Caryophylli supercritical CO
2Extract 1.8kg, chlorxylone 2.2kg, AES (polyoxyethylenated alcohol sodium sulfate) 1.5kg, polyoxyethylene (40) castor oil hydrogenated 1.4kg are dissolved in the mixed solution of ethanol 35.0kg ethanol and 4.5kg propylene glycol at normal temperatures, zinc phenolsulfonate 5.0kg is dissolved in the 50kg deionized water, then water-soluble liquid phase is inserted alcoholic solution mutually in, add essence 0.3kg, homogenizing 10min filters and promptly gets this liniment.
Claims (2)
1, a kind of osmidrosis dispelling liniment that contains natural Zingiber corallinum Hance essential oil is characterized in that preparing as follows:
(1) takes by weighing each component by following mass fraction: Rhizoma Zingiberis corallini quintessence oil 0.5～5.0, Flos Chrysanthemi Indici supercritical CO
2Extract 0.2～2.0, the Flos Caryophylli supercritical CO
2Extract 0.3～3.0, zinc phenolsulfonate 2.0～8.0, chlorxylone 0.5～4.0, propylene glycol 1.0～8.0, ethanol 20.0～50.0, polyoxyethylene (40) castor oil hydrogenated 0.1～2.0, polyoxyethylenated alcohol sodium sulfate 0.1～3.0, essence 0.1～0.5, deionized water 40.0～60.0;
(2) earlier with Rhizoma Zingiberis corallini quintessence oil, Flos Chrysanthemi Indici supercritical CO
2Extract, Flos Caryophylli supercritical CO
2Extract, chlorxylone, polyoxyethylenated alcohol sodium sulfate, polyoxyethylene (40) castor oil hydrogenated are dissolved in the mixed solution of ethanol and propylene glycol at normal temperatures, then zinc phenolsulfonate is dissolved in the deionized water, at last water-soluble liquid phase is inserted alcoholic solution mutually in, add essence, homogenizing 5～30 minutes filters promptly.
2, the osmidrosis dispelling liniment that contains natural Zingiber corallinum Hance essential oil as claimed in claim 1, wherein the mass fraction of described each component of step (1) is: Rhizoma Zingiberis corallini quintessence oil 1～4.0, Flos Chrysanthemi Indici supercritical CO
2Extract 0.8～1.5, the Flos Caryophylli supercritical CO
2Extract 1.0～2.0, zinc phenolsulfonate 4.0～6.0, chlorxylone 1.0～2.0, propylene glycol 2.0～6.0, ethanol 25.0～45.0, polyoxyethylene (40) castor oil hydrogenated 0.5～1.5, polyoxyethylenated alcohol sodium sulfate 0.5～2.5, essence 0.2～0.4, deionized water 45.0～55.0.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230354A (en) * | 2013-05-03 | 2013-08-07 | 肇庆迪彩日化科技有限公司 | Sweating suppression deodorant composition |
| CN107519246A (en) * | 2016-06-20 | 2017-12-29 | 重庆灵方生物技术有限公司 | A kind of osmidrosis dispelling liniment |
| CN110124042A (en) * | 2019-05-28 | 2019-08-16 | 赵叶莲 | The composition of inhibition underarm odor without aluminium |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1132633A (en) * | 1995-04-04 | 1996-10-09 | 张俊巍 | Application of Glehnia littoralis in health product and cosmetics |
| CN1130056A (en) * | 1995-10-16 | 1996-09-04 | 谢家祥 | Hair nursing and growing liquid prepared from coral ginger extract |
| CN1879703A (en) * | 2006-05-13 | 2006-12-20 | 王浩贵 | An externally applied medicine for treating hicismus |
| CN101138346A (en) * | 2007-10-30 | 2008-03-12 | 贵阳舒美达制药厂有限公司 | Disinfectant liquid containing coral ginger oil and preparing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230354A (en) * | 2013-05-03 | 2013-08-07 | 肇庆迪彩日化科技有限公司 | Sweating suppression deodorant composition |
| CN103230354B (en) * | 2013-05-03 | 2015-01-21 | 肇庆迪彩日化科技有限公司 | Sweating suppression deodorant composition |
| CN107519246A (en) * | 2016-06-20 | 2017-12-29 | 重庆灵方生物技术有限公司 | A kind of osmidrosis dispelling liniment |
| CN110124042A (en) * | 2019-05-28 | 2019-08-16 | 赵叶莲 | The composition of inhibition underarm odor without aluminium |
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| CN101336966B (en) | 2011-07-27 |
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