CN110124042A - The composition of inhibition underarm odor without aluminium - Google Patents
The composition of inhibition underarm odor without aluminium Download PDFInfo
- Publication number
- CN110124042A CN110124042A CN201910448380.8A CN201910448380A CN110124042A CN 110124042 A CN110124042 A CN 110124042A CN 201910448380 A CN201910448380 A CN 201910448380A CN 110124042 A CN110124042 A CN 110124042A
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- China
- Prior art keywords
- zinc
- acid
- composition
- aluminium
- inhibition
- Prior art date
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- Pending
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- 229910052782 aluminium Inorganic materials 0.000 title claims abstract description 20
- 239000004411 aluminium Substances 0.000 title claims abstract description 20
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- 230000005764 inhibitory process Effects 0.000 title claims abstract description 17
- 150000003751 zinc Chemical class 0.000 claims abstract description 23
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- 239000002243 precursor Substances 0.000 claims abstract description 18
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- -1 lysine-zn Chemical compound 0.000 claims description 23
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 16
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- 229940096998 ursolic acid Drugs 0.000 claims description 10
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims description 10
- FRWNAQDBODEVAL-VMPITWQZSA-N (5e)-5-[(4-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Chemical compound C1=CC([N+](=O)[O-])=CC=C1\C=C\1C(=O)NC(=S)S/1 FRWNAQDBODEVAL-VMPITWQZSA-N 0.000 claims description 9
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- 235000011187 glycerol Nutrition 0.000 claims description 7
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 6
- 241001092040 Crataegus Species 0.000 claims description 6
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 6
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 6
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 6
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- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 6
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 6
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 6
- 241000191967 Staphylococcus aureus Species 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
- 239000012752 auxiliary agent Substances 0.000 claims description 6
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 6
- 229940110280 zinc methionine Drugs 0.000 claims description 6
- CNMFGFBWPBBGKX-SCGRZTRASA-L zinc;(2s)-2-amino-4-methylsulfanylbutanoate Chemical compound [Zn+2].CSCC[C@H](N)C([O-])=O.CSCC[C@H](N)C([O-])=O CNMFGFBWPBBGKX-SCGRZTRASA-L 0.000 claims description 6
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 5
- 229960001763 zinc sulfate Drugs 0.000 claims description 5
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 5
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 4
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- RCVXUZDXWKYWDH-UHFFFAOYSA-N tetradecyl 2,3-dihydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(O)CO RCVXUZDXWKYWDH-UHFFFAOYSA-N 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940093609 tricaprylin Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- DUNKXUFBGCUVQW-UHFFFAOYSA-J zirconium tetrachloride Chemical compound Cl[Zr](Cl)(Cl)Cl DUNKXUFBGCUVQW-UHFFFAOYSA-J 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
A kind of composition of the inhibition underarm odor without aluminium, using pentacyclic triterpenoid monomer or monomer composition 0.01%-5%, soluble single aglucon or polygamy base zinc salt 0.5%-10%, 1-DNJ or derivatives thereof 0-5.0% is main active, by inhibiting the transhipment of body odour object precursor, killing to play the role of bacterium, the inhibition armpit top gland sweat secretion of decomposition to body odour object precursor, achieve the purpose that inhibit underarm odor.The features such as the composition is no aluminium porcelain enamelling, and clear with component, mechanism is clear, and safety is used for a long time, rapid-action, and effect is good, and lasting.
Description
Technical field
The invention belongs to biomedicine field, be related to the compositions such as pentacyclic triterpenoid and zinc salt preparation underarm odor control
Treat the purposes in drug.
Background technique
The smell is awful for underarm odor, pollutes clothes, is painful and trouble a problem.Certain people are to offending smell
Frightened, detest or psychological allergy are shown, some people's smell neurosis are even resulted in.Underarm odor seriously affects work, life and society
It hands over.In Japan, underarm odor is considered as a kind of disease, is the project of national health insurance.Underarm odor crowd is in the Asians such as China
About 20%.
Currently, anti-underarm odor drug on the market is mostly antiperspirant, by inhibiting the apocrine sweat gland of oxter to perspire, inhibit underarm odor
Generate, wherein main antiperspirant is aluminium chloride or basic zirconium chloride aluminium, the shortcomings that these antiperspirants is: 1) mechanism is not
It is bright;2) aluminium may influence nervous system, and there are uncertain safeties;3) there are the side effects such as skin darkening or allergy.Due to aluminium
Safety uncertainty, therefore, exploitation is free of the osmidrosis treatment drug of aluminium, is the master of current osmidrosis treatment pharmaceutical preparation research and development
Want direction.
Summary of the invention
It is needed in view of the shortcomings of the prior art with market, the inhibition underarm odor without aluminium that the purpose of the present invention is to provide a kind of
Composition.It is intended to overcome the uncertainty of the safety of aluminium.
The present invention starts with from the following aspects, and 1) inhibit axillary apocrine to perspire, quantity of perspiration is reduced, i.e. reduction sordes matter
The secretory volume of precursor;2) activity for inhibiting MRP8 reduces body odour object precursor to external transhipment;It reduces in sweat before sordes matter
The amount of body;3) bacterium that can decompose smelly precursors is killed.
Inhibition perspires, and reduces the amount of oxter body odor substance, can play a part of to inhibit underarm odor.It perspires in vivo complicated by one
Mechanism control.Studies have shown that calcium ion activated chloride channel CFTR (L é rias, Pinto et al., Cellular
Signalling, 2018,10-19) and TMEM16A (Wilson and Metzler-Wilson, Experimental
Dermatology, 2015,177-178) it plays an important role in the forming process of primary sweat.TMEM16A is in apocrine secretion
It is expressed in liquid gland, ephidrosis is related with the transcripton of the gene in apocrine secretion liquid gland shearing diversity.Theoretically, inhibit
TMEM16A may perspire inhibition and play an important role.
Human scent is a kind of mixture (Takeuchi, the Yabuki et of complicated volatile organic matter (VOCs)
al., Flavour & Fragrance Journal, 2013, 223–230).Underarm odor be by C2-C11 just, branch and not
The complex mixture of unsaturated organic acid composition, main component is euro -3- methyl -2- hexenoic acid (E-3M2H), 3- hydroxyl -3-
Methylhexanoic acid (3H3M), 3- hydroxy-3-methyl caproic acid (HMHA) and volatile sulfur compounds, especially 3- methyl -3-
Sulphur -1- alcohol (3M3SH) (Martin, Saathoff et al., Journal of Investigative
Dermatology, 2010,529-540), this sulfur-containing compound is typically found in very low level, but is had very high
Odor impact power (i.e. low odor threshold).Volatilize sex steroid, such as 5 α-androgen -16- alkene -3- ketone (androsterone) and 5 α-hero
- 3 β -ol of steroid -16- alkene (androstene sterol), is initially considered related with underarm odor, but the later contribution found to sense organ and analysis is very
Small (Prokop-Prigge, Greene et al., J Chem Ecol, 2016,33-39).Armpit apocrine secretion liquid is being secreted
When itself be odorless, it is mutual in the armpit microbiologic population of skin surface but due to precursor containing underarm odor in apocrine secretion liquid
Under effect, the smell substances such as 3M2H, HMHA and 3M3SH can be generated.The glutamine conjugate of the sordes matter such as 3M2H, HMHA,
Such as: cys-gly- (S) conjugate (Barzantny, the Brune et of 3M2H-Gln, HMHA-Gln and 3M3SH
Al., International Journal of Cosmetic Science, 2012,2-11) (such as Fig. 2), it is considered to be it closes
Precursor (Martin, Saathoff et al., Journal of Investigative of the body odour object of key
Dermatology, 2010, 529-540, Baumann, Bergmann et al., Experimental
Dermatology, 2014, 247–252).There are mainly of two types for the biggish bacterial population of density in armpit, golden yellow Portugal
Grape coccus (Staphylococcus epidermidis) (Leyden, Mcginley et al., Journal of
Investigative Dermatology, 1981,413-416) and with corynebacteria (Corynebacterium xerosis) (Barzantny, Brune et al., International Journal of Cosmetic Science,
2012, 2-11).Having found that has very strong correlation (Prokop- between the biggish corynebacteria of density and strong underarm odor
Prigge, Greene et al., J Chem Ecol, 2016,33-39).Therefore, it can kill or inhibit these bacterial growths
Substance, have inhibit underarm odor effect.
Studies have shown that the secretion of body odour object precursor is related with the ABCC11 gene of people, the polarization in the apocrine sweat gland of people
In cell, the transport protein matter MRP8 of this gene expression one body odour precursors, without in the crowd of underarm odor, this base
It (is G180R) on protein because 538G > A mutation has occurred.It can be detected in sweat gland in the patient's armpit for having underarm odor
The gene phenotype of ABCC11 is the protein expression of 538GG and 538GA.And it is examined in people's armpit sweat gland that genotype is AA
The expression (Toyoda, Takada et al., Int J Mol Sci, 2017) for not detecting ABCC11 is because of G180R
Mutation compromises N- glycosylation of the MRP8 on two residues of Asn838 and Asn844 in extracellular loop, reduces albumen
The stability of matter, to become easy degradation (Saito, Osumi et al., Aaps Journal, 2009,581).
The MRP8 albumen of ABCC11 coding plays an important role in the excretory function of armpit top gland.Heterozygote (GA) and homozygote
(GG) a physical efficiency secrets out of these body odour precursors in vitro, then, under bacterial action, is metabolized to stink substances.AA is homozygous
The ABCC11 afunction of the armpit top gland of Ziren, the secretion quilt of specific odoring substance amino acid conjugates (body odour object precursor)
It blocks, the secretion for savouring substance and its precursor significantly reduces.These statistics indicate that MRP8 secretion sweat gland in smell and its
Key effect (Martin, Saathoff et al., Journal of Investigative is played in precursor
Dermatology, 2010, 529-540).Possess the prerequisite that allele G is underarm odor expression.Therefore, theoretically, press down
MRP8 activity processed, can reduce the transhipment of body odour precursors;Alpha-glucosidase restrainer can inhibit the N- of protein to glycosylate,
The stability of MRP8 protein can be reduced, to reduce its protein level, can achieve the purpose that inhibit underarm odor.
The technical solution adopted by the present invention to solve the technical problems is: providing a kind of combination of inhibition underarm odor without aluminium
Object, it is characterised in that including following component: 1) antiperspirant inhibits apocrine sweat gland to perspire;2) MRP8 inhibitor inhibits smelly precursors
Transhipment;3) antibacterial agent, can inhibit epidermis staphylococcus aureus (Staphylococcus epidermidis) and rod-like stem
Bacterium (Corynebacterium xerosis) growth;4) auxiliary material.
1) antiperspirant
The antiperspirant is a kind of zinc salt, and this kind of compound contains the polygamy base zinc salt of two or more aglucons, wherein wrapping
Include amino-acid zinc, i.e. glycine zine, alanine zinc, zinc methionine, glutamine zinc, aspartic acid zinc, zinc glutamate, lysine
Zinc, valine zinc, zinc-methionine, isoleucine zinc, phenylalanine zinc, proline zinc, tryptophan zinc, serine zinc, tyrosine
Zinc, Zinc cysteinate, zinc methionine, glutamine zinc, threonine zinc, arginine zinc, histidine zinc, zinc taurine;With it is polynary
Zinc salts of organic acid, i.e. zinc citrate, Tartaric acid zinc, zinc malate, malonic acid zinc, zinc oxalate etc., but it is not limited to these compounds.
The carboxyls containing one or more or amido in each molecule of these compounds, energy and Zn2+Form multiple coordinate bonds.
These zinc salts further include the zinc salt of single aglucon, i.e. zinc gluconate, zinc lactate, ZINC P-PHENOLSULFONATE, zinc sulfate, zinc chloride
With zinc acetate etc., but it is not limited to these compounds.
Zn2+It can inhibit the activity of chloride channel TMEM6A, the formation of primary sweat can be inhibited.Preferably by a kind of or
It is a variety of have compounded containing two or more aglucon zinc salts with the zinc salt of single aglucon of one or more solubilities.Dosage is
0.5%-20%。
2) MRP8 inhibitor
The inhibitor of the MRP8 is a kind of pentacyclic triterpenoid, comprising: enoxolone (Glycyrrhetic acid),
Hawthorn acid (Maslinic acid), oleanolic acid (Oleanolic acid), ursolic acid (Ursolic Acid), Corosolic acid
(Corosolic acid) and asiatic acid (Asiatic acid) and its salt and its derivative.This kind of compound can directly be made
For MRP8 protein, in conjunction with MRP8, inhibits its activity, in formula, can be one such or several combinations,
Its dosage accounts for the 0.01%-5% of total weight.
The inhibitor of the MRP8 is also possible to a kind of alpha-glucosidase restrainer, may include: 1- deoxidation open country buttocks
Mycin and its derivative, such as: 1-DNJ, Beagle spy, Miglitol, and containing the natural of 1-DNJ
Extract, such as: mulberry-leaf extract, this substance inhibit the N- of MRP8 to glycosylate, reduce by inhibiting alpha-glucosidase
MRP8 stability achievees the purpose that inhibit body odour precursors transhipment, dosage accounts for total weight to reduce MRP8 level
0-5%.
Zn2+The activity that can inhibit alpha-glucosidase, polygamy base zinc salt, list containing above-mentioned two or more than two aglucons
The zinc salt and its compound of aglucon are also the inhibitor of MRP8 simultaneously, can reduce MRP8 level, before having inhibition body odour substance
The effect of body transhipment.
3) antibacterial agent
The antibacterial agent is pentacyclic triterpenoid, comprising: enoxolone (Glycyrrhetic acid), hawthorn acid
(Maslinic acid), oleanolic acid (Oleanolic acid), ursolic acid (Ursolic Acid), Corosolic acid
(Corosolic acid) and asiatic acid (Asiatic acid) and its derivative etc..
The antibacterial agent can be a kind of antibacterial enhancing agent, i.e. zinc salt, contain the more of above-mentioned two or more than two aglucons
Aglucon zinc salt, Dan Peiji zinc salt and its compound while also a kind of antibacterial enhancing agent.
4) auxiliary material
The auxiliary material can be surfactant, cosurfactant, grease, conditioner, preservative, one in acidity regulator
Kind or several compoundings.
Surfactant: the surfactant is a kind of nonionic surfactant, such as: fatty alcohol (8-18 carbon)
Polyoxyethylene ether (12-20) is (such as: steareth-20, isosteareth-12, isoceteth-20, ceteareth-20
Deng);Polyoxyethylene ether (12-25) fatty acid (8-18 carbon) ester is (such as: polyethylene glycol (23) isostearate, polyethylene glycol
(14) oleate, CO40);(such as: polyethylene glycol (20) lauric acid is sweet for polyethylene glycol (6-23) fatty acid (8-18 carbon) glyceride
Grease, polyethylene glycol (20) olein etc.);Polyethylene glycol sorbitan mono fatty acid (8-18 carbon) ester (TW-
20, TW-80 etc.);Fatty acid monosaccharide or polysaccharide esters;Or amphoteric surfactant, such as: lecithin;Anionic surfactant:
Such as: lauryl sodium sulfate;It can be one of or several compoundings.
Cosurfactant: it can be short chain alcohol (C2-C6) such as: ethyl alcohol, propyl alcohol, butanol, 1- hexanol etc.;Polyalcohol is such as:
Propylene glycol, 1,2- butanediol, 1,2- pentanediol, 1,2- hexylene glycol, 1,2- ethohexadiol, glycerine, 1,3- butanol etc.;Short chain acids
Such as: propionic acid, butyric acid, oleic acid;Polyethylene glycols are such as: diethylene glycol ether (carbitol), polyethylene glycol 400 (PEG400), formamide,
Butyl lactate etc.;Amino acids, such as: lysine.Antibacterial agent Spectrastat PHL, which also has, good helps surface-active
Agent effect can be one of or several compoundings.
Grease: the grease can be the esters of short chain, such as: isopropyl myristate, isopropyl palmitate, carbonic acid two
Monooctyl ester, caprylic/capric triglyceride, triethylglycerides, tributyrin, tricaprylin, Capmul PG-8, the third two
Two Off-Shoot-O of alcohol, hexanedioic acid diisopropyl ester, hexanedioic acid dibutyl ester, isopropyl palmitate, ethyl oleate, n butyl oleate, acetyl
Change monoglyceride, ethyl acetate, ethyl butyrate, ethyl caprilate, injection stage soybean oil etc..But it is some to have certain hydrophilic oil
Ester, such as: monoglyceride (glyceryl monolaurate, single grease glyceride, single iso stearate ester, monomyristyl glycerate etc., list
Glycerol caprylate), lactate (such as: lauryl alcohol lactate, myristyl alcohol lactate, C12-13 alcohol lactate, isooctadecanol cream
Acid esters etc.) etc., it can be one of or how compound.
Conditioner: glycerol, propylene glycol, volatile silicone oils, vitamin E etc., antibacterial agent Spectrastat PHL be can be
Also there is opsonic action.
Preservative: can be that some irritations are small, mild preservative, such as: 1,2- hexylene glycol, Spectrastat PHL
Deng.
Acidity regulator, penetration-assisting agent and antioxidant: triethanolamine can be selected in acidity regulator;Azone may be selected in penetration-assisting agent;
Antioxidant selects VE.
The beneficial effects of the present invention are: 1) mechanism is clear, and definite ingredients, 2) aluminium is free of, the crow support without releasable formaldehyde
Safety is used for a long time in product;3) rapid-action, effect is lasting.
Detailed description of the invention
The invention will be further described with reference to the accompanying drawing.
Fig. 1 is the compound chemical structure figure that can be used to inhibit underarm odor.A is pentacyclic triterpenoid.B is that 1- deoxidation is wild
Buttocks mycin (1-DNJ) and its derivative.
Fig. 2 is the body odour object precursor chemical structure chart in armpit apocrine secretion liquid.
Fig. 3 is the component schematic diagram of the embodiment of the present invention.
Fig. 4 is that pentacyclic triterpenoid inhibits MRP8 to the outlet schematic diagram of methotrexate (MTX).
Fig. 5 is that pentacyclic triterpenoid inhibits MRP8 to the IC of the outlet of methotrexate (MTX)50(μM) schematic diagram.
Fig. 6 is minimum inhibitory concentration (MIC) (μ g/ml) schematic diagram to two kinds of underarm odor Related Bacterias of test sample.
Fig. 7 is that several compounds adjust MRP8 level view in cell.
Fig. 8 is that composition compounds component schematic diagram in each embodiment.
Specific embodiment
Referring to Fig. 3, a kind of composition embodiment of the inhibition underarm odor without aluminium of the present invention is a kind of microemulsion, described group
Part composition includes the three parts mixing of basic microemulsion, active constituent and other auxiliary agents, accounts for component in total weight are as follows:
Basic microemulsion: lauryl alcohol lactate (LA-20) 1%-10%, PEG40 castor oil (CO40) 0.5%-10%, glycerine 1%-
20%, dehydrated alcohol 1%-30%, water 30%-80%;Basic microemulsion is transparent, can infinite dilution, and can be according to the molten of contained active matter
Xie Xing selects LA-20 to compound with other greases, such as: LA-20 and ethyl oleate, LA-20 and carbonic diester;
Active constituent: pentacyclic triterpenoid monomer or monomer composition 0.01%-5%, soluble single aglucon or polygamy base zinc
Salt or combinations thereof object 0.5%-10%, 1- dechlorination nojirimycin or derivatives thereof 0-5%.
Other auxiliary agents: lauryl sodium sulfate (K12) 0-3.0%, fatty acid cane sugar ester (SE) 0-3.0%, Spectrastat
PHL 0.1%-4%, azone 0.1%-3%, VE 0-1%, lysine 0.5%-4%, triethanolamine 0.5%-5%, water add to 100%.These
Auxiliary agent can enhance the loading capacity of pentacyclic triterpenoid, improve the dissolubility of polygamy base zinc salt.
The present embodiment is that load active constituent and other auxiliary agents are made on the basis of basic micro emulsion formula of liquid.
Experiment 1: the inhibiting effect that pentacyclic triterpenoid transports MRP8 outlet
In order to measure pentacyclic triterpenoid to the inhibiting effect of MRP8, the cell of MRP8 overexpression is first prepared.It clones first
ABCC11 gene, bibliography (Leier, Jedlitschky et al., Journal of Biological
Chemistry,1994, 27807-27810, Bera, Lee et al., Molecular Medicine, 2001, 509-
516) method, using 5 '-CCT AGT ACT GAT CAC CTGCGC ATC GCT-3 ' and 5 '-AGC GAT GCG CAG
Two primers of GTG ATC ACT AGG-3 ' carry out RACE PCR, and the PCR product of 4.1 kb is cloned into pcDNA3.1 and is carried
Body, obtain plasmid pcDNA3.1 ABCC11, then transfect LLC-PK1 cell, G418 obtains the LLC-PK1- for being overexpressed MRP8 by screening
ABCC11 stable cell line.Pentacyclic triterpenoid to MRP8 outlet inhibiting effect, using LC-MS/MS (Tun-Yhong,
Chinpaisal et al., Antimicrobial Agents & Chemotherapy, 2017, AAC.01725-
01716) method.Firstly, the stable cell line of MRP8 will be expressed with 3 × 105It is a to be inoculated in 12 orifice plates, wherein being cultivated containing M199
Base, 3% heat-inactivated fetal calf serum, 100 μ g/ml are dual anti-and the puromycin hydrochloride of 2 μ g/ml.Cell is in 37 DEG C, 5
The CO of %224 h are cultivated in incubator, the sample being dissolved in DMSO is diluted with culture medium, and then cell is with final concentration of 10 μM
Pentacyclic triterpenoid in 37 DEG C, 5 % CO2 Be incubated for 1 h, add 160 μM of methotrexate (MTX)s (Methotrexate,
MTX), in 37 DEG C, 5 % CO2Shaking table is incubated for 1 h, is washed cell 3 times with the PBS that ice was educated, removes extracellular drug,
Cell is counted, then, floats cell again with the methanol that 100 μ l 70 % (v/v) ice was educated, -20 DEG C of overnight incubations add
Enter 5 μ l(chloramphenicol of inner mark solution, 1.6 μ g/ml), 10,000g 15 min of centrifugation remove cell fragment, using LC-MS/MS
Measure the content of wherein methotrexate (MTX).Liquid chromatogram separates the mobile phase used are as follows: acetonitrile: 1 mM ammonium formate (contains 0.1 % first
Acid) be 18:82(v/v), flow velocity is 0.4 ml/min, using analytical column (C18 Zorbax Eclipse XDB, Agilent
, U.S.A.), 35 DEG C of column temperature.
Experiments have shown that (referring to fig. 4), in the LLC-PK1 cell of expression MRP8, when there is no pentacyclic triterpenoid to deposit
When, methotrexate (MTX) is because by MRP8 outlet, the content in cell is very low.10 μM enoxolone (Glycyrrhetic acid,
GA), hawthorn sour (Maslinic acid, MA), oleanolic acid (Oleanolic acid, OA), ursolic acid (Ursolic Acid,
UA), Corosolic acid (Corosolic acid, CA) and asiatic acid (Asiatic acid, AA) can significantly inhibit
Transhipment of the MRP8 to methotrexate (MTX) improves intake of the cell to methotrexate (MTX), therefore these pentacyclic triterpenoids can inhibit
The transhipment of MRP8 (referring to Fig. 5).
Experiment 2: antibacterial activity of the pentacyclic triterpenoid to epidermis staphylococcus aureus and corynebacteria
Pentacyclic triterpenoid has the antibacterial activity of staphylococcus aureus and corynebacteria, experiment with bacterial species: epidermis
Staphylococcus aureus (Staphylococcus epidermidis) and corynebacteria (Corynebacterium xerosis), it is the main relevant bacteria species of underarm odor.Test sample are as follows: enoxolone (Glycyrrhetic acid, GA), hawthorn acid
(Maslinic acid, MA), oleanolic acid (Oleanolic acid, OA), ursolic acid (Ursolic Acid, UA), koroso
Acid (Corosolic acid, CA) and asiatic acid (Asiatic acid, AA) etc. are the positive with Kanamycin Sulfate
Control, using methanol as negative control.Measuring method bibliography method (Rahman M.& Gray A.,
Phytochemistry, 2005,66 :1601-1606).Sample to be tested, Kanamycin Sulfate are dissolved in methanol respectively
(MeOH) in, the solution for becoming l mg/ml is prepared.The resazurin indicator of 100 μ g/ml is added to 96 porocyte culture plates
The 12nd column hole in, the resazurin solution and 5 ml of 7. 5 ml100 μ g/ml are containing bacterium (106 cfu/ml, OD=O.07)
Culture solution mix, be then respectively adding to 1-11 column in, be added in each culture hole the above-mentioned resazurin of 100 μ l and bacterium training
The mixture of nutrient solution.The sample being dissolved in DMSO, is diluted with culture medium, then is added into first hole of each column in culture plate
100 μ l concentration are the test sample of l mg/ml, mix, therefrom draw 100 μ l solution and get in second hole, according to this class
It pushes away, until the tenth hole, finally removes 100 μ l.The concentration of test sample changes are as follows: 500 μ g/ml, 250 μ g/ml, 125 μ
G/ml, 62.5 μ g/ml, 31.2 μ g/ml, 15.6 μ g/ml, 7.8 μ g/ml, 3.9 μ g/ml, 1.9 μ g/ml and 0.9 μ g/ml;Then
Culture plate is placed on 370It is cultivated in the incubator of C 5-6 hours, not becoming pink from blue indicates antibacterial activity.When the 11st
When column culture solution becomes pink from blue, it is test sample that the last one, which does not become sample concentration in the hole of pink from blue,
Minimum inhibitory concentration (MIC).The result shows that (Fig. 6), these pentacyclic triterpenoids are to staphylococcus aureus and rod-like stem
Bacterium has good antibacterial activity.
Test 3:1- 1-Deoxynojirimycin (1-DNJ) and Zn2+ To the inhibiting effect of MRP8
1-DNJ is alpha-glucosidase restrainer.We have detected 1-DNJ, mulberry-leaf extract and
Zn2+ Inhibitor effect to the stability of MRP8.MDCKII cell in DMEM (contain calf serum 10%, it is dual anti-1%)
In 37 DEG C of 5% CO2Incubator in cultivate.By plasmid pcDNA3.1 ABCC11 transfect MDCKII cell, transfect 48 hours
Afterwards, cell is separately added into the 1-DNJ of 4.0 μ g/ml, the mulberry-leaf extract of 400 μ g/ml, 50 μ g/ml glucose
Sour zinc, 10 μ g/ml zinc sulfate, then it is incubated for 24 h.Glycosidase PNGase F is added in lytic cell, in 37 DEG C of 10 min of processing,
Then protein Western Blot analysis is carried out.
As a result such as Fig. 7.This is it is demonstrated experimentally that the adjustable MRP8 of 1-DNJ is horizontal, this is because 1- deoxidation
Nojirimycin is alpha-glucosidase restrainer, can inhibit N- glycosylation of the MRP8 on 838 and 844.Mulberry
Contain the 1-DNJ of 1 %-5 % in leaf extract.The N substituent of 1-DNJ, such as: Beagle spy, rice
Lattice column alcohol and the glycosylated inhibitor of N-, should be able to reduce the level of MRP8.
50 μ g/ml zinc gluconates and 10 μ g/ml zinc sulfate can also reduce MRP8 level, this may be with Zn2+ Energy
Inhibit alpha-glucosidase related, to reduce the N- level of glycosylation of MRP8.
Since these substances can inhibit the N- of MRP8 to glycosylate, to reduce the stability of MRP8, its albumen is reduced
Matter is horizontal, therefore, 1-DNJ and Zn2+ It can inhibit the transhipment of sordes matter.
Test 4:Zn2+ Inhibit the chloride ion outflow of TMEM16A induction
Inhibit the Cl in sweat gland cells- Outflow can inhibit the formation of primary sweat, achieve the purpose that inhibit to perspire.Mankind's sweat
Gland cell system NCL-SG3 (10 % containing calf serum, dual anti-1 %) in William's E culture medium, cell density is
20,000 cells/well, in 96 orifice plates of black, in 37 DEG C of 5 % CO2 Incubator in cultivate.By yellow fluorescence
The consolidation constitution grain pCDNA3.1-YFP (H148Q/I152L/F46L) of albumen is transferred in cell.Second day, 200 μ of every hole
The PBS of l is washed 3 times, every hole addition 50 μ l PBS, 0.5 μ l untested compound DMSO solution, after 10 min,
Intracellular background fluorescence (intensifying 500 ± 10 nm of light, emit 535 ± 15 nm of light) is measured on FLIPR Tetr, background is glimmering
Light makees positive control (inhibiting rate is 0 %) and then 50 μ l is added and (are used for containing 140 mM NaI and 200 μM of ATP solution
Measure TMEM16A, Ca2+Activation) after 6 min, measure the fluorescence in each hole.When the TMEM16A in cell is activated by ATP
When, extracellular I- ion enters cell, Cl- Cell is flowed out, the yellow fluorescence of YFP is by I in cell- It is quenched, fluorescence is strong
Degree reduce, using in the presence of ATP without the measured value under the conditions of untested compound as negative control (inhibiting rate is 100 %).Change
Close the inhibiting rate of object are as follows: value-positive control value of 1-(untested compound)/100 % of (negative control value-positive control value) X,
And calculate IC50.Zinc gluconate inhibits Cl- The IC of outflow50Value be 80.85 ± 0.28 μM, zinc sulfate be 10.85 ±
0.28 μM, therefore, contain Zn2+ Compound has antiperspirant effect.
The present invention can be a kind of creme or a kind of tincture or a kind of spray or a kind of Roll on agent.
Production method
According to the formula (Fig. 8) of the embodiment, produced using the following method.
Embodiment 1:
It mixes according to the ratio, dress is packed into spray bottle, is spray.This agent side is transparent, stablizes.
Embodiment 2:
According to the ratio, by enoxolone (GA), 1-DNJ (1-DNJ), cetearyl alcohol alcohol ether -6 (A6), cetearyl alcohol
Alcohol/cetearyl alcohol alcohol ether -25 (A25), fatty acid cane sugar ester (SE), lauryl alcohol lactate (LA20), PGCC,
Spectrastat PHL, azone, vitamin E (VE), triethanolamine, glycerol, dehydrated alcohol are mixed to Quan Rong, by lysine plus
Enter into solvable single aglucon zinc solution of 10 % and dissolve, is then added in the mixed liquor of front, stirs half an hour, obtain transparent
Microemulsion, be fitted into spray bottle, be spray.
Embodiment 3:
According to the ratio, by enoxolone (GA), 1-DNJ (1-DNJ), CO40, lauryl alcohol lactate (LA20),
Spectrastat PHL, azone, vitamin E (VE), triethanolamine, glycerol, dehydrated alcohol are mixed to Quan Rong, by lysine plus
Enter into solvable single aglucon zinc solution of 10 % and dissolve, is then added in the mixed liquor of front, stirs half an hour, obtain transparent
Microemulsion, be fitted into spray bottle, be spray.
Embodiment 4:
According to the ratio, enoxolone (GA), CO40, lauryl alcohol lactate (LA20), Spectrastat PHL, azone, dimension are given birth to
Plain E (VE), triethanolamine, glycerol, dehydrated alcohol are mixed to Quan Rong, add fatty acid cane sugar ester (SE), lysine, solvable
It is dissolved in single aglucon zinc salt and polygamy base zinc solution, adds water to 100 %, stir half an hour, obtain transparent lotion, be packed into spray
Bottle is spray.
Claims (6)
1. a kind of composition of the inhibition underarm odor without aluminium, it is characterised in that including being free of aluminium component: 1) antiperspirant as follows, inhibit
Apocrine sweat gland perspires;2) MRP8 inhibitor inhibits the transhipment of smelly precursors;3) antibacterial agent inhibits epidermis staphylococcus aureus
And corynebacteria;4) auxiliary material.
2. the composition of the inhibition underarm odor according to claim 1 without aluminium, it is characterised in that: the antiperspirant is polygamy
Base zinc salt and single aglucon zinc salt, including amino-acid zinc, alanine zinc, zinc methionine, glutamine zinc, aspartic acid zinc,
Zinc glutamate, lysine-zn, valine zinc, zinc-methionine, isoleucine zinc, phenylalanine zinc, proline zinc, tryptophan zinc,
Serine zinc, tyrosine zinc, Zinc cysteinate, zinc methionine, glutamine zinc, threonine zinc, arginine zinc, histidine zinc,
Zinc taurine;With multicomponent organic acid zinc salt, i.e. zinc citrate, Tartaric acid zinc, zinc malate, malonic acid zinc, zinc oxalate;Single aglucon
Zinc salt can be one such including zinc gluconate, zinc lactate, ZINC P-PHENOLSULFONATE, zinc sulfate, zinc chloride and zinc acetate
The compounding of a variety of compoundings or polygamy base zinc salt and single aglucon zinc salt, dosage are 0.5 %-20 % of overall weight.
3. the composition of the inhibition underarm odor according to claim 1 without aluminium, it is characterised in that: the inhibition of the MRP8
Agent is pentacyclic triterpenoid and its derivative, including enoxolone, hawthorn acid, oleanolic acid, ursolic acid, Corosolic acid or
Asiatic acid and its salt and derivative, can be one such or several combinations, and dosage accounts for 0.01 %-5 of total weight
%。
4. the composition of the inhibition underarm odor according to claim 1 without aluminium, it is characterised in that: the suppression of the MRP8
Preparation is alpha-glucosidase restrainer, 1-DNJ and its derivative, including 1-DNJ, Beagle
Special, Miglitol, can be one such or several combinations, dosage accounts for the 0-5 % of total weight.
5. the composition of the inhibition underarm odor according to claim 1 without aluminium, it is characterised in that: the antibacterial agent is five rings
Triterpene compound and its derivative, including careless hypo acid, hawthorn acid, oleanolic acid, ursolic acid, Corosolic acid or asiatic acid,
And its salt and derivative.
6. the composition of the inhibition underarm odor according to claim 1 without aluminium, it is characterised in that: the component be include base
Plinth microemulsion, active constituent and the mixing of other auxiliary agent three parts, account for component in total weight and are respectively as follows:
Basic microemulsion: 1 %-10 % of lauryl alcohol lactate, 0.5 %-10 % of PEG40 castor oil, 1 %-20 % of glycerine, anhydrous
1 %-30 % of ethyl alcohol, 30 %-80 % of water;
Active constituent: 0.01 %-5 % of pentacyclic triterpenoid monomer or monomer composition, soluble single aglucon or polygamy base
0.5 %-10 % of zinc salt or composition, 1- dechlorination nojirimycin or derivatives thereof 0-5 %;
Other auxiliary agents: lauryl sodium sulfate 0-3.0 %, fatty acid cane sugar ester 0-3.0 %, 0.1 %- of Spectrastat PHL
4 %, 0.1 %-3 % of azone, VE 0-1 %, 0.5 %-4 % of lysine, 0.5 %-5 % of triethanolamine, water add to 100 %.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022122598A1 (en) * | 2020-12-07 | 2022-06-16 | Unilever Ip Holdings B.V. | Antiperspirant compositions |
CN117717492A (en) * | 2023-12-19 | 2024-03-19 | 中山自然说生物科技有限公司 | Biological agent for repairing armpit microecology and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101336966A (en) * | 2008-08-14 | 2009-01-07 | 重庆灵方生物技术有限公司 | Osmidrosis dispelling liniment containing natural essential oil of Zingiber corallinum Hance |
CN102151287A (en) * | 2010-12-14 | 2011-08-17 | 徐玉仙 | Bromhidrosis treating powder |
CN104622703A (en) * | 2013-11-14 | 2015-05-20 | 无锡丝源化妆品有限公司 | Deodorant powder and preparation method thereof |
WO2018023126A1 (en) * | 2016-07-29 | 2018-02-01 | Kaspar Roger L | Methods of treating osmidrosis |
-
2019
- 2019-05-28 CN CN201910448380.8A patent/CN110124042A/en active Pending
- 2019-05-28 CN CN202311204331.2A patent/CN116999557A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101336966A (en) * | 2008-08-14 | 2009-01-07 | 重庆灵方生物技术有限公司 | Osmidrosis dispelling liniment containing natural essential oil of Zingiber corallinum Hance |
CN102151287A (en) * | 2010-12-14 | 2011-08-17 | 徐玉仙 | Bromhidrosis treating powder |
CN104622703A (en) * | 2013-11-14 | 2015-05-20 | 无锡丝源化妆品有限公司 | Deodorant powder and preparation method thereof |
WO2018023126A1 (en) * | 2016-07-29 | 2018-02-01 | Kaspar Roger L | Methods of treating osmidrosis |
Non-Patent Citations (7)
Title |
---|
ANNETTE MARTIN ET AL.: "A Functional ABCC11 Allele Is Essential in the Biochemical Formation of Human Axillary Odor", 《JOURNAL OF INVESTIGATIVE DERMATOLOGY》 * |
YU TOYODA ET AL.: "Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition", 《PLOS ONE》 * |
孙杨等: "ABCC11基因单核苷酸多态性与中国汉族人群腋臭发病的相关性研究", 《中南大学学报(医学版)》 * |
宋有涛等: "《分子伴侣与蛋白质错误折叠》", 31 March 2012, 辽宁科学技术出版社 * |
杨建峰等: "《老偏方》", 30 November 2014, 江西科学技术出版社 * |
陈正伦: "《兽医中药药理学》", 31 May 1995, 中国农业出版社 * |
黄荣: "《化妆品制备基础》", 31 May 2015, 四川大学出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022122598A1 (en) * | 2020-12-07 | 2022-06-16 | Unilever Ip Holdings B.V. | Antiperspirant compositions |
CN117717492A (en) * | 2023-12-19 | 2024-03-19 | 中山自然说生物科技有限公司 | Biological agent for repairing armpit microecology and preparation method and application thereof |
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