JP2019081763A - Cleaning composition - Google Patents
Cleaning composition Download PDFInfo
- Publication number
- JP2019081763A JP2019081763A JP2018245901A JP2018245901A JP2019081763A JP 2019081763 A JP2019081763 A JP 2019081763A JP 2018245901 A JP2018245901 A JP 2018245901A JP 2018245901 A JP2018245901 A JP 2018245901A JP 2019081763 A JP2019081763 A JP 2019081763A
- Authority
- JP
- Japan
- Prior art keywords
- mass
- cleaning composition
- salt
- surfactant
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 117
- 238000004140 cleaning Methods 0.000 title claims abstract description 81
- 244000269722 Thea sinensis Species 0.000 claims abstract description 52
- 239000000284 extract Substances 0.000 claims abstract description 51
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims abstract description 49
- 229960002509 miconazole Drugs 0.000 claims abstract description 48
- 150000003839 salts Chemical class 0.000 claims abstract description 42
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 40
- 235000009569 green tea Nutrition 0.000 claims abstract description 38
- 239000004094 surface-active agent Substances 0.000 claims abstract description 34
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 33
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 33
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 31
- 208000035985 Body Odor Diseases 0.000 claims abstract description 20
- 206010040904 Skin odour abnormal Diseases 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 19
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 14
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims abstract description 14
- 235000010262 sodium metabisulphite Nutrition 0.000 claims abstract description 14
- 235000013616 tea Nutrition 0.000 claims abstract description 14
- 229930003799 tocopherol Natural products 0.000 claims abstract description 14
- 239000011732 tocopherol Substances 0.000 claims abstract description 14
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 12
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 12
- 229960001295 tocopherol Drugs 0.000 claims abstract description 12
- 229940046009 vitamin E Drugs 0.000 claims abstract description 12
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 12
- 239000011709 vitamin E Substances 0.000 claims abstract description 12
- 239000002537 cosmetic Substances 0.000 claims abstract description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 46
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 33
- 239000000194 fatty acid Substances 0.000 claims description 33
- 229930195729 fatty acid Natural products 0.000 claims description 33
- -1 fatty acid ester Chemical class 0.000 claims description 29
- 150000004665 fatty acids Chemical class 0.000 claims description 29
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- 239000003240 coconut oil Substances 0.000 claims description 25
- 235000019864 coconut oil Nutrition 0.000 claims description 25
- 229960003237 betaine Drugs 0.000 claims description 23
- 239000002280 amphoteric surfactant Substances 0.000 claims description 21
- 239000000344 soap Substances 0.000 claims description 17
- 239000002453 shampoo Substances 0.000 claims description 15
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims description 14
- 229960005040 miconazole nitrate Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000011734 sodium Substances 0.000 claims description 12
- 235000013772 propylene glycol Nutrition 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- 239000003945 anionic surfactant Substances 0.000 claims description 10
- NBDYSLCMCUDINP-UHFFFAOYSA-N 3-[dodecanoyl(methyl)amino]propanoic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)N(C)CCC(O)=O NBDYSLCMCUDINP-UHFFFAOYSA-N 0.000 claims description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 239000002736 nonionic surfactant Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- SUZRRICLUFMAQD-UHFFFAOYSA-N N-Methyltaurine Chemical compound CNCCS(O)(=O)=O SUZRRICLUFMAQD-UHFFFAOYSA-N 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000003002 pH adjusting agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 229930195712 glutamate Natural products 0.000 claims description 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 claims description 3
- 239000004359 castor oil Substances 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 229960002449 glycine Drugs 0.000 claims description 3
- 235000013905 glycine and its sodium salt Nutrition 0.000 claims description 3
- 229940078455 sodium lauroyl aspartate Drugs 0.000 claims description 3
- IEXXLSKKBWIDAC-ZOWNYOTGSA-M sodium;(3s)-3-(dodecanoylamino)-4-hydroxy-4-oxobutanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CC(O)=O IEXXLSKKBWIDAC-ZOWNYOTGSA-M 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 108010077895 Sarcosine Proteins 0.000 claims description 2
- OBHAIFOMZXGPIA-DFWYDOINSA-N [Na].CN[C@@H](C)C(O)=O Chemical compound [Na].CN[C@@H](C)C(O)=O OBHAIFOMZXGPIA-DFWYDOINSA-N 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 229940009098 aspartate Drugs 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 229940043230 sarcosine Drugs 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 2
- 229940049906 glutamate Drugs 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 229940073490 sodium glutamate Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 abstract description 8
- 238000000197 pyrolysis Methods 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 description 40
- 235000019645 odor Nutrition 0.000 description 35
- 239000004480 active ingredient Substances 0.000 description 25
- 238000012360 testing method Methods 0.000 description 25
- 230000000052 comparative effect Effects 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 10
- BSAIUMLZVGUGKX-UHFFFAOYSA-N non-2-enal Chemical group CCCCCCC=CC=O BSAIUMLZVGUGKX-UHFFFAOYSA-N 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 9
- 239000003429 antifungal agent Substances 0.000 description 9
- 229940121375 antifungal agent Drugs 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000013329 compounding Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
- 229960000984 tocofersolan Drugs 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 3
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000555688 Malassezia furfur Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 239000012449 sabouraud dextrose agar Substances 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 229940001584 sodium metabisulfite Drugs 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229940005605 valeric acid Drugs 0.000 description 3
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 3
- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 2
- ZDSCFBCGDDCJFZ-UHFFFAOYSA-N 2-(methylamino)ethanesulfonic acid;sodium Chemical compound [Na].CNCCS(O)(=O)=O ZDSCFBCGDDCJFZ-UHFFFAOYSA-N 0.000 description 2
- LGYNIFWIKSEESD-UHFFFAOYSA-N 2-ethylhexanal Chemical compound CCCCC(CC)C=O LGYNIFWIKSEESD-UHFFFAOYSA-N 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 2
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000555676 Malassezia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 229920006317 cationic polymer Polymers 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
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- 239000012895 dilution Substances 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
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- 239000002609 medium Substances 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 description 2
- 235000010265 sodium sulphite Nutrition 0.000 description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 235000019149 tocopherols Nutrition 0.000 description 2
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- 229940070710 valerate Drugs 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical class OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
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Landscapes
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Abstract
Description
本発明は、ミコナゾールおよび／またはその塩を安定的に含有する、および／または体臭等の不快臭抑制効果を有する、医薬品、医薬部外品または化粧品用の洗浄用組成物に関する。 The present invention relates to a cleaning composition for pharmaceuticals, quasi-drugs or cosmetics, which stably contains miconazole and / or a salt thereof and / or has an unpleasant odor suppressing effect such as body odor.
ミコナゾールは、イミダゾール系抗真菌剤として汎用されている。頭部皮膚の常在真菌の１つであるPityrosporum ovaleに対する抗菌効果も認められ、これを有効成分とするふけ防止剤が知られている（特許文献１参照）。また、ミコナゾールを含む洗浄用組成物のCandida albicans、Malassezia furfurに対する抗真菌活性（特許文献２参照）を含むマラセチア属真菌に対する抗真菌活性も確かめられている。
ミコナゾールをふけ防止成分として配合した頭皮シャンプー（医薬部外品）はすでに市販されている。
Miconazole is widely used as an imidazole antifungal agent. Antibacterial effects have also been observed against Pityrosporum ovale, which is one of the permanent fungi of head skin, and anti-dandruff agents containing this as an active ingredient are known (see Patent Document 1). In addition, antifungal activity against Malassezia fungi including antifungal activity against Candida albicans and Malassezia furfur of a cleaning composition containing miconazole (see Patent Document 2) has also been confirmed.
Scalp shampoos (quasi-drugs) formulated with miconazole as an antidandruff component are already commercially available.
上記のようなミコナゾールを有効成分（抗真菌剤）として配合した洗浄用組成物について、経時的な安定性を検討したところ、場合によって所定期間保存後に有効成分の含量（定量値）低下を示すことがあるという知見を得た。具体的には、共存する洗浄剤（界面活性剤）のロットなどにより有効成分の所定期間保存後の含量が低下することがあるのが認められた。このため界面活性剤による何らかの影響が推測されるが、その因果関係を明確にすることは困難である。
また、近年の清潔志向の高まりから、体臭の発生防止、および／または発生した体臭の消臭により、体臭を効果的に抑制できる洗浄用組成物の提供が望まれている。
そして、これらの性質の少なくとも１つを改善する洗浄用組成物を提供することが本発明の課題である。
When the stability over time was examined about the cleaning composition which blended the above miconazole as an active ingredient (antifungal agent), it showed the content (quantitative value) fall of the active ingredient after storage for a predetermined period depending on the case Found that there is Specifically, it was found that the content of the active ingredient after storage for a predetermined period might be reduced due to the lot of coexisting detergent (surfactant). For this reason, although the influence by surfactant is inferred, it is difficult to clarify the causal relationship.
Further, from the recent increase in cleanliness, it is desired to provide a cleaning composition capable of effectively suppressing body odor by preventing generation of body odor and / or deodorizing the generated body odor.
It is an object of the present invention to provide a cleaning composition which improves at least one of these properties.
上記のような知見から、本発明は、洗浄用組成物調製後も、界面活性剤などの共存成分に左右されず、有効成分ミコナゾールを配合された所定量で持続し得る洗浄用組成物を提供することを目的とする。このような課題について検討したところ、抗真菌剤の有効成分としてミコナゾールおよび／またはその塩を含有する洗浄用組成物に、特定の化合物を添加することにより、有効成分の含量低下を抑制しうることを見出した。本願で特定される化合物は、一般的に抗酸化剤として分類される化合物であるが、従来、抗酸化剤として洗浄用組成物に汎用されている亜硫酸ナトリウム等を添加した場合に比べ、本願で特定する化合物は、ミコナゾールの含量低下に対し格別な抑制効果を示す。
また、発明者らの検討により、ミコナゾールを含む洗浄組成物において、特定の化合物を添加することにより、不快臭の種類を問わずに優れた不快臭抑制効果を有することが確認された。
したがって、本願は、抗真菌剤の有効成分としてミコナゾールおよび／またはその塩を含有する洗浄用組成物における有効成分の安定化（含量低下抑制）剤としての化合物、該化合物を含む有効成分が安定化された洗浄用組成物に係る以下のような本発明を提供する。
また、抗真菌剤の有効成分としてミコナゾールおよび／またはその塩を含有する不快臭抑制効果に優れる洗浄用組成物に係る以下のような本発明を提供する。
From the above findings, the present invention provides a cleaning composition which can be sustained in a predetermined amount containing the active ingredient miconazole regardless of the coexisting component such as a surfactant even after preparation of the cleaning composition. The purpose is to When such a subject was examined, the content reduction of an active ingredient can be suppressed by adding a specific compound to the cleaning composition containing miconazole and / or its salt as an active ingredient of an antifungal agent. Found out. The compound specified in the present application is a compound generally classified as an antioxidant, but in the present application, compared with the case where sodium sulfite etc., which are widely used in cleaning compositions as an antioxidant, is added conventionally, The compound to be identified exhibits a remarkable inhibitory effect on the reduction in miconazole content.
Moreover, it was confirmed that the cleaning composition containing miconazole has an excellent unpleasant odor suppressing effect regardless of the type of unpleasant odor in the cleaning composition containing miconazole according to the investigation of the inventors.
Therefore, the present application relates to a compound as a stabilizer (suppression of content reduction) of an active ingredient in a cleaning composition containing miconazole and / or a salt thereof as an active ingredient of an antifungal agent, an active ingredient containing the compound is stabilized The present invention provides the following cleaning composition.
In addition, the following present invention is provided according to a cleaning composition having excellent unpleasant odor inhibitory effect, which comprises miconazole and / or a salt thereof as an active ingredient of an antifungal agent.
本発明の第１の態様は、
（Ａ）ミコナゾールおよび／またはその塩、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤、ならびに
（Ｃ）界面活性剤
を含有する、医薬品、医薬部外品または化粧品用の洗浄用組成物である。
また本発明の別の態様は、
（Ａ）ミコナゾールおよび／またはその塩、
（Ｂ）カキタンニンおよび／または薬用炭、ならびに
（Ｃ）界面活性剤
を含有する、医薬品、医薬部外品または化粧品用の洗浄用組成物である。
The first aspect of the present invention is
(A) miconazole and / or a salt thereof
Drugs and quasi-drugs comprising (B) at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract, and (C) a surfactant Or it is a cleaning composition for cosmetics.
Another aspect of the present invention is
(A) miconazole and / or a salt thereof
It is a cleaning composition for medicines, quasi-drugs or cosmetics, which comprises (B) kashitannin and / or medicinal charcoal, and (C) a surfactant.
前記（Ｃ）界面活性剤が、アニオン界面活性剤、両性界面活性剤およびノニオン界面活性剤からなる群より選ばれる少なくとも１種である態様の前記洗浄用組成物。 The cleaning composition according to the embodiment, wherein the (C) surfactant is at least one selected from the group consisting of an anionic surfactant, an amphoteric surfactant and a nonionic surfactant.
前記（Ｂ）抗酸化剤を２種以上含む態様の前記洗浄用組成物。 The said cleaning composition of the aspect containing 2 or more types of said (B) antioxidant.
前記組成物全量に対し、通常、
（Ａ）ミコナゾールおよび／またはその塩を０．１〜２．０質量％、
（Ｂ）抗酸化剤を０．００１〜５．０質量％、ならびに
（Ｃ）界面活性剤を５．０〜５０質量％、好ましくは残部水を、
含有する前記いずれかの洗浄用組成物。
本発明の洗浄用組成物は、上記組成範囲の濃縮物または希釈物で提供される場合があり、この場合も本発明の組成物に含まれる。
Usually, with respect to the total amount of the composition,
(A) 0.1 to 2.0% by mass of miconazole and / or a salt thereof,
(B) 0.001 to 5.0% by mass of an antioxidant, and (C) 5.0 to 50% by mass of a surfactant, preferably the remaining water,
Any one of the above-mentioned cleaning compositions containing.
The cleaning composition of the present invention may be provided as a concentrate or dilution of the above composition range, and is also included in the composition of the present invention.
シャンプー（頭髪用シャンプー、ドライシャンプー、リンスインシャンプー等）または石鹸（固形石鹸、液体石鹸、泡状石鹸、ボディソープ、ハンドソープ、フェイシャルソープ等）である態様の前記洗浄用組成物。 The above cleaning composition according to an embodiment which is a shampoo (hair shampoo, dry shampoo, rinse-in shampoo etc.) or a soap (solid soap, liquid soap, foamy soap, body soap, hand soap, facial soap etc.).
本発明の第２の態様は、
（Ａ）ミコナゾールおよび／またはその塩、ならびに（Ｃ）界面活性剤を含有する洗浄用組成物に配合するための、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤からなる、前記（Ａ）ミコナゾールおよび／またはその塩の安定化剤である。
The second aspect of the present invention is
For blending into a cleaning composition comprising (A) miconazole and / or a salt thereof, and (C) a surfactant,
(B) A stabilizer for miconazole (A) and / or a salt thereof as described in (A) comprising at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract is there.
本発明の第３の態様は、
（Ａ）ミコナゾールおよび／またはその塩と、
（Ｂ）緑茶乾留エキスと、
（Ｃ）界面活性剤とを含有する医薬品、医薬部外品または化粧品用の洗浄用組成物である。
The third aspect of the present invention is
(A) miconazole and / or a salt thereof
(B) Green tea dry distilled extract,
(C) A cleaning composition for pharmaceuticals, quasi-drugs or cosmetics containing a surfactant.
本発明の第４の態様は、
（Ａ）ミコナゾールおよび／またはその塩と、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤と、
（Ｃ）界面活性剤とを含有する体臭抑制剤または体臭抑制用組成物である。
The fourth aspect of the present invention is
(A) miconazole and / or a salt thereof
(B) at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract,
(C) A body odor suppressor or a composition for suppressing body odor, which comprises a surfactant.
前記体臭抑制剤または体臭抑制用組成物が、ノネナール、ｉ−吉草酸、メチルメルカプタン、アンモニア、２−エチルヘキサナール、６−メチル−５−ペプテン−２−オン、ヘキサン酸、および酢酸から選択される少なくとも１種の不快臭を抑制する前記体臭抑制剤または体臭抑制用組成物。 The body odor inhibitor or composition for suppressing body odor is selected from nonenal, i-valerate, methyl mercaptan, ammonia, 2-ethylhexanal, 6-methyl-5-pept-2-one, hexanoic acid, and acetic acid The body odor suppressant or the composition for suppressing body odor according to any one of the above, which suppresses at least one unpleasant odor.
また、本発明は、（Ａ）ミコナゾールおよび／またはその塩、ならびに（Ｃ）界面活性剤を含有する洗浄用組成物に、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤を併用することにより、前記（Ａ）ミコナゾールおよび／またはその塩を安定化する方法も提供することができる。本発明において併用とは、同時に適用する、別々に適用する、時間的に前後に分けて適用する、配合剤とする、２剤としてセットにすることを含む。
The present invention also relates to a cleaning composition comprising (A) miconazole and / or a salt thereof, and (C) a surfactant.
(B) Stabilization of (A) miconazole and / or its salt by using in combination at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract It is also possible to provide a way to In the present invention, combined use includes simultaneous application, separate application, time-wise divided application, combination agent, and two-agent combination.
また、本発明は、（Ａ）ミコナゾールおよび／またはその塩、ならびに（Ｃ）界面活性剤を含有する洗浄用組成物に、
（Ｂ）緑茶乾留エキスを併用することにより、体臭を抑制する方法も提供することができる。
The present invention also relates to a cleaning composition comprising (A) miconazole and / or a salt thereof, and (C) a surfactant.
(B) A method for suppressing body odor can also be provided by using green tea distilled extract in combination.
本発明によれば、界面活性剤などの共存成分に左右されず、有効成分ミコナゾールの経時的な含量低下を抑制し、または配合された所定量で有効成分を持続し得る洗浄用組成物を提供することができる。また、体臭等の不快臭を効果的に抑制する洗浄用組成物を提供することができる。 According to the present invention, there is provided a cleaning composition capable of suppressing the time-dependent decrease in the content of the active ingredient miconazole or maintaining the active ingredient in a predetermined amount without being influenced by coexisting components such as surfactants. can do. Moreover, the composition for washing | cleaning which suppresses unpleasant odors, such as a body odor, effectively can be provided.
本発明に係る洗浄用組成物は、抗真菌剤の有効成分として（Ａ）ミコナゾールおよび／またはその塩を含む。
ミコナゾールは、化学名１−［（２ＲＳ）−２−（２，４−ジクロロベンジルオキシ）−２−（２，４−ジクロロフェニル）エチル］−１Ｈ−イミダゾールの公知化合物である。ミコナゾールの抗真菌スペクトルは知られており、たとえば前述のとおりCandida albicans、Malassezia 属真菌に対する抗菌効果が確認されている。
塩としては、硝酸塩、塩酸塩などが挙げられる。ミコナゾールおよびその塩は市販品として入手可能である。ミコナゾールおよびその塩のうちでも、配合のしやすさなどの点からミコナゾール硝酸塩が好ましい。
配合量は、特に限定されないが、ミコナゾール硝酸塩の場合には、組成物全量に対し、通常０.１〜２.０質量％であり、好ましくは０.１〜１.０質量％であり、さらに好ましくは０．５〜１．０質量％である。
The cleaning composition according to the present invention comprises (A) miconazole and / or a salt thereof as an active ingredient of an antifungal agent.
Miconazole is a known compound of the chemical name 1-[(2RS) -2- (2,4-dichlorobenzyloxy) -2- (2,4-dichlorophenyl) ethyl] -1H-imidazole. The antifungal spectrum of miconazole is known, and for example, as described above, the antibacterial effect on Candida albicans and Malassezia fungi has been confirmed.
As the salt, nitrate, hydrochloride and the like can be mentioned. Miconazole and its salts are commercially available. Of the miconazole and salts thereof, miconazole nitrate is preferred in terms of ease of formulation and the like.
The compounding amount is not particularly limited, but in the case of miconazole nitrate, it is usually 0.1 to 2.0% by mass, preferably 0.1 to 1.0% by mass, relative to the total amount of the composition, and further, Preferably it is 0.5-1.0 mass%.
本発明に係る洗浄用組成物は、ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の（Ｂ）抗酸化剤を含む。
ピロ亜硫酸ナトリウムは、Ｎａ2Ｓ2Ｏ5で示される化合物で、二亜硫酸二ナトリウムやメタ重亜硫酸ナトリウムとも呼ばれる。
トコフェロールは、トコールの各種（α、β、γ、δ）メチル化誘導体であり、合成によって生成されたものでも、植物から抽出する等により天然から得られたものであってもよく、１種または２種以上を組み合わせてもよい。トコフェロールとしては具体的には、dl−α−トコフェロール、酢酸dl−α−トコフェロール、d−α−トコフェロール、d−β−トコフェロール、d−γ−トコフェロール、d−δ−トコフェロールなどがあり、好ましくは、dl−α−トコフェロール、d−δ−トコフェロールである。
天然ビタミンＥは、ダイズ等の植物から抽出して得られるもので、d−α−トコフェロール、d−β−トコフェロール、d−γ−トコフェロール、d−δ−トコフェロールの混合物である。
緑茶乾留エキスは、緑茶を減圧下、乾留によって得られる液で、エタノールまたはプロピレングリコールを含むエキスである。市販品としては、白井松新薬株式会社のフレッシュＥ、ＦＳ−１０００、ＦＳ−５００Ｇなどがある。
茶エキスは、緑茶から水、エタノール、エタノール溶液、プロピレングリコール溶液、またはグリセリン溶液で抽出して得られるエキスである。市販品としては、丸善製薬株式会社の緑茶抽出液ＬＡ、香栄興業株式会社の茶抽出液Ｓ、一丸ファルコス株式会社の緑茶リキッドなどがある。
これら物質は、いずれも市販品として入手可能である。
（Ｂ）抗酸化剤として、上記物質の２種以上を組合せて使用することもできる。
（Ｂ）抗酸化剤の配合量は、用いる物質によっても異なるが、組成物全量に対し、（Ｂ）抗酸化剤の全量で、通常、０．００１〜５．０質量％であり、好ましくは０．１〜２．０質量％である。
The cleaning composition according to the present invention comprises at least one (B) antioxidant selected from the group consisting of sodium metabisulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract.
Sodium metabisulfite is a compound represented by Na 2 S 2 O 5 and is also called disodium bisulfite or sodium metabisulfite.
Tocopherols are various (α, β, γ, δ) methylated derivatives of tocol, which may be synthetically produced or naturally obtained by extraction from plants, etc. Two or more may be combined. Specific examples of tocopherols include dl-α-tocopherol, dl-α-tocopherol acetate, d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-δ-tocopherol and the like, with preference given to , Dl-α-tocopherol and d-δ-tocopherol.
Natural vitamin E is obtained by extraction from a plant such as soybean and is a mixture of d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol and d-δ-tocopherol.
Green tea dry-distilled extract is a liquid obtained by dry-distilling green tea under reduced pressure, and is an extract containing ethanol or propylene glycol. Commercially available products include Fresh E, FS-1000, FS-500G, etc. by Shirai Matsu Shinyaku Co., Ltd.
The tea extract is an extract obtained by extracting green tea with water, ethanol, an ethanol solution, a propylene glycol solution, or a glycerin solution. Commercially available products include green tea extract solution LA of Maruzen Pharmaceutical Co., Ltd., tea extract solution S of Koei Kogyo Co., Ltd., green tea liquid of Ichimaru Falcos Co., Ltd., and the like.
All of these substances are commercially available.
(B) It is also possible to use two or more of the above-mentioned substances in combination as an antioxidant.
The blending amount of the antioxidant (B) varies depending on the substance used, but the total amount of the antioxidant (B) is usually 0.001 to 5.0% by mass, preferably the total amount of the composition. It is 0.1-2.0 mass%.
（Ｂ）緑茶乾留エキスの場合、組成物全体に対し、（Ｂ）抗酸化剤の全量で、通常、０．００１〜５．０質量％であり、好ましくは０．１〜２．０質量％であり、より好ましくは０．２〜２．０質量％であり、さらに好ましくは０．７５〜１．５質量％である。
また、（Ａ）ミコナゾールおよび／またはその塩、と緑茶乾留エキスの配合比は質量比で１：０．５〜５が好ましく、より好ましくは１：１〜３、さらに好ましくは１：１〜２である。
In the case of (B) green tea dry-distilled extract, the total amount of (B) antioxidant is usually 0.001 to 5.0% by mass, preferably 0.1 to 2.0% by mass, based on the whole composition. More preferably, it is 0.2-2.0 mass%, More preferably, it is 0.75-1.5 mass%.
In addition, the mixing ratio of (A) miconazole and / or a salt thereof to green tea dry-distilled extract is preferably 1: 0.5-5, more preferably 1: 1-3, still more preferably 1: 1-2 by mass ratio. It is.
上記で特定される（Ｂ）抗酸化剤は、（Ａ）ミコナゾールおよび／またはその塩を抗真菌剤の有効成分として含む洗浄用組成物において、有効成分の保存時含量低下を抑制する効果を奏する。すなわち（Ａ）ミコナゾールおよび／またはその塩を含む洗浄用組成物の加速試験において、組成物中の（Ａ）ミコナゾールおよび／またはその塩の含量の低下が認められることがあるが、上記（Ｂ）特定の抗酸化剤を配合することで、含量の低下は抑制される。
なお、含量の低下とは、洗浄用組成物の製造直後の有効成分の含量に対して、組成物の安定性に関する加速試験、たとえば、４０℃、湿度７５％の条件下での２ヶ月間の試験において、有効成分の含量が低下することを表す。含量の低下の抑制程度は、好ましくは、４０℃、湿度７５％の条件下での２ヶ月間の試験において、有効成分の含量が試験開始前の９５％以上に保たれている状態である。洗浄用組成物中の有効成分の含量の測定方法としては、例えば、液体クロマトグラフィーによる測定が挙げられる。
The antioxidant (B) specified above exerts the effect of suppressing the decrease in storage content of the active ingredient in the cleaning composition containing (A) miconazole and / or a salt thereof as the active ingredient of the antifungal agent. . That is, in the accelerated test of the cleaning composition containing (A) miconazole and / or a salt thereof, a decrease in the content of (A) miconazole and / or a salt thereof in the composition may be observed. The reduction of the content is suppressed by blending a specific antioxidant.
Note that the decrease in content means an accelerated test on the stability of the composition relative to the content of the active ingredient immediately after the preparation of the cleaning composition, for example, two months under the conditions of 40 ° C. and 75% humidity. In the test, it indicates that the content of the active ingredient decreases. The degree of suppression of the reduction in content is preferably such that the content of the active ingredient is maintained at 95% or more before the start of the test in a two-month test under conditions of 40 ° C. and 75% humidity. Examples of the method for measuring the content of the active ingredient in the cleaning composition include measurement by liquid chromatography.
（Ｂ）抗酸化剤として緑茶乾留エキスを用いる場合、（Ａ）ミコナゾールおよび／またはその塩を抗真菌剤の有効成分として含む洗浄用組成物において、体臭等の不快臭を抑制する効果を奏するため特に好ましい。すなわち、本発明の好ましい態様は、（Ａ）ミコナゾールおよび／またはその塩、（Ｂ）緑茶乾留エキス、（Ｃ）界面活性剤を含有する、医薬品、医薬部外品または化粧品用の洗浄用組成物である。また、本発明の好ましい別の態様は、（Ａ）ミコナゾールおよび／またはその塩、（Ｂ）緑茶乾留エキス、（Ｃ）界面活性剤を含有する、体臭抑制剤または体臭抑制用組成物である。不快臭は特に限定されないが、例えば、ヒトが不快に感じる臭い、悪臭、ヒトを含む動物の体臭、が挙げられる。体臭の原因物質としては、ノネナール、ｉ−吉草酸、メチルメルカプタン、アンモニア、２−エチルヘキサナール、６−メチル−５−ペプテン−２−オン、ヘキサン酸、および酢酸があげられ、これらの少なくとも２種以上、好ましくは３種以上、より好ましくは４種以上の物質に対して抑制効果があればよい。特に、ノネナール、ｉ−吉草酸、メチルメルカプタン、およびアンモニアから選択される少なくとも２種、好ましくは３種、より好ましくは４種全てに対して抑制効果があればさらによい。 (B) When a green tea dry-distilled extract is used as an antioxidant, (A) a cleaning composition containing miconazole and / or a salt thereof as an active ingredient of an antimycotic agent to exert an effect of suppressing unpleasant odor such as body odor Particularly preferred. That is, a preferred embodiment of the present invention is a cleaning composition for pharmaceuticals, quasi-drugs or cosmetics, which comprises (A) miconazole and / or a salt thereof, (B) green tea distilled extract, (C) a surfactant. It is. In addition, another preferable embodiment of the present invention is a body odor suppressant or a composition for suppressing body odor, which comprises (A) miconazole and / or a salt thereof, (B) green tea dry extract, (C) a surfactant. The unpleasant odor is not particularly limited, and examples thereof include odors that humans feel unpleasant, malodors, and body odors of animals including humans. Substances causing body odor include nonenal, i-valerate, methyl mercaptan, ammonia, 2-ethylhexanal, 6-methyl-5-pepten-2-one, hexanoic acid, and acetic acid, and at least two of these are included. As described above, preferably, three or more types, and more preferably four or more types of substances may be effective. In particular, it is further better if there is an inhibitory effect on at least two, preferably three, and more preferably all four selected from nonenal, i-valeric acid, methyl mercaptan and ammonia.
不快臭抑制効果は、ヒトが臭いを抑制できたと感じれば特に限定されないが、例えば、上記洗浄用組成物を使用した場合に、不快臭の原因物質の１種または複数種が、洗浄用組成物を使用しなかった場合の検出量を１００％としたとき５０％、好ましくは６０％、より好ましくは８０％以上除去されていればよい。かかる除去率の評価方法は公知の方法で行うことができるが、例えば後述の試験例２を用いて評価できる。また、不快臭の有無はヒトの主観によるところもあるため、官能試験により評価しても良い。官能試験による場合には臭いの評点を、例えば３〜１０段階に分けて評価し、本発明の洗浄用組成物の使用により評定が向上していればよい。
不快臭の除去率はヒトでの試験や、後述の試験例２のようなｉｎ ｖｉｔｒｏの試験では、洗浄用組成物の使用後、密閉環境または開放環境において、室温や夏場を想定した温度（例えば３０℃や４０℃）で、例えば、３０分後、１時間後、３時間後、６時間後、１２時間後、２４時間後に評価することが出来る。加速試験を行う場合には、例えば、４０℃、湿度７５％の条件下での３０分間後に評価することが出来る。
The unpleasant odor suppressing effect is not particularly limited as long as the human feels that the odor can be suppressed. For example, when the above-mentioned composition for cleaning is used, one or more of the substances causing offensive odor are the cleaning composition. When the detection amount when not using is 100%, 50%, preferably 60%, more preferably 80% or more may be removed. Although the evaluation method of this removal rate can be performed by a well-known method, it can evaluate using the below-mentioned test example 2, for example. Moreover, since the presence or absence of an unpleasant odor may depend on human subjectivity, it may be evaluated by a sensory test. In the case of sensory test, the odor score may be evaluated, for example, in 3 to 10 stages, and the evaluation may be improved by the use of the cleaning composition of the present invention.
The removal rate of unpleasant odor is the temperature (for example, room temperature or summer) assumed in a closed environment or an open environment after using the cleaning composition in a human test or an in vitro test such as test example 2 described later For example, after 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours, evaluation can be made at 30 ° C. and 40 ° C.). When performing an accelerated test, for example, it can be evaluated after 30 minutes under conditions of 40 ° C. and 75% humidity.
本発明では、上記（Ｂ）抗酸化剤に加え、他の抗酸化剤を配合しても構わない。他の抗酸化剤は、人体への安全性が確認されているものであれば特に制限なく配合することができるが、たとえば、亜硫酸ナトリウム、ピロクトンオラミン、ジブチルヒドロキシトルエン（ＢＨＴ）、ブチルヒドロキシアニソール（ＢＨＡ）、没食子酸プロピル、アスコルビン酸およびその塩、エリソルビン酸およびその塩、トコトリエノール、フェルラ酸などを用いることができる。これらは、上記（Ｂ）抗酸化剤とは別に、通常使用される量で任意に配合することができる。
また、本発明では、上記（Ｂ）抗酸化剤に代えて、カキタンニンおよび／または薬用炭を配合してもよい。配合量は抗酸化剤と同様の範囲で任意に選択することができる。
In the present invention, in addition to the above-mentioned (B) antioxidant, another antioxidant may be blended. Other antioxidants can be added without particular limitation as long as they have been confirmed to be safe for the human body. For example, sodium sulfite, pirocton olamine, dibutyl hydroxytoluene (BHT), butyl hydroxy Anisole (BHA), propyl gallate, ascorbic acid and salts thereof, erythorbic acid and salts thereof, tocotrienol, ferulic acid and the like can be used. These can be optionally blended in amounts usually used separately from the above (B) antioxidant.
Further, in the present invention, oyster tannin and / or medicinal charcoal may be blended instead of the above-mentioned (B) antioxidant. The compounding amount can be arbitrarily selected in the same range as the antioxidant.
本発明において、洗浄成分の（Ｃ）界面活性剤は、アニオン界面活性剤、両性界面活性剤およびノニオン界面活性剤からなる群より選ばれる少なくとも１種である。
具体的に、アニオン界面活性剤としては、たとえば、脂肪酸塩、アルキル硫酸エステル塩、モノアルキルリン酸エステル塩、アルキルエーテル硫酸エステル塩、ポリオキシエチレンアルキルエーテル硫酸エステル、ポリオキシエチレンアルキルエーテルリン酸エステル塩、ポリオキシエチレンアルキルエーテル酢酸塩、高級脂肪酸アルカノールアミド硫酸エステル塩、アシルイセチオン酸塩、アルキルスルホコハク酸塩、α−オレフィンスルホン酸塩、アルキルエーテルカルボン酸塩、アシル乳酸塩、Ｎ−アシルサルコシン塩、Ｎ−アシルグルタミン酸塩、Ｎ−アシルメチルアラニン塩、Ｎ−アシルメチルタウリン塩、Ｎ−アシルアスパラギン酸塩、ラウレス硫酸ナトリウムなどが挙げられる。
In the present invention, the (C) surfactant of the cleaning component is at least one selected from the group consisting of an anionic surfactant, an amphoteric surfactant and a nonionic surfactant.
Specifically, as the anionic surfactant, for example, fatty acid salt, alkyl sulfate ester salt, monoalkyl phosphate ester salt, alkyl ether sulfate ester salt, polyoxyethylene alkyl ether sulfate ester, polyoxyethylene alkyl ether phosphate ester Salt, polyoxyethylene alkyl ether acetate, higher fatty acid alkanolamide sulfate, acyl isethionate, alkyl sulfosuccinate, α-olefin sulfonate, alkyl ether carboxylate, acyl lactate, N-acyl sarcosine salt, N-acyl glutamate, N-acyl methyl alanine salt, N-acyl methyl taurine salt, N-acyl aspartate, sodium laureth sulfate and the like.
両性界面活性剤としては、たとえば、スルホベタイン型両性界面活性剤、アミノプロピオン型両性界面活性剤、アミノ酢酸ベタイン型両性界面活性剤（ラウリン酸アミドプロピルベタインなど）、グリシン型両性界面活性剤、イミダゾリン型両性界面活性剤などが挙げられる。 Examples of amphoteric surfactants include sulfobetaine-type amphoteric surfactants, aminopropion-type amphoteric surfactants, aminoacetic acid betaine-type amphoteric surfactants (such as lauric amidopropyl betaine), glycine-type amphoteric surfactants, and imidazolines. And amphoteric surfactants.
ノニオン界面活性剤としては、脂肪酸アルカノールアミド、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンアルキルエーテル（ポリオキシエチレンラウリルエーテルなど）、アルキルグリコシド、ポリオキシエチレンソルビタン脂肪酸エステルなどが挙げられる。
上記界面活性剤は全て市販品として入手可能である。また、２種以上の界面活性剤を適宜組み合わせて使用することができる。
界面活性剤の組み合わせとしては、ラウロイルメチル-β-アラニンナトリウム、２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタイン、ヤシ油脂肪酸ジエタノールアミドの３種を含む態様や、ラウロイルメチル-β-アラニンナトリウム、ヤシ油脂肪酸メチルタウリンナトリウム、ラウリルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピルベタインおよびヤシ油脂肪酸ジエタノールアミドから選択される少なくとも４種を含む態様が好ましい。
Examples of the nonionic surfactant include fatty acid alkanolamide, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether (such as polyoxyethylene lauryl ether), alkyl glycoside, polyoxyethylene sorbitan fatty acid ester and the like.
The above surfactants are all commercially available. In addition, two or more surfactants can be used in appropriate combination.
As a combination of surfactants, an embodiment including sodium lauroyl methyl-β-alanine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, coconut oil fatty acid diethanolamide, lauroyl methyl- Preferred is an embodiment comprising at least four selected from sodium β-alanine, sodium coconut oil fatty acid methyl taurine, lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine and coconut oil fatty acid diethanolamide.
界面活性剤は、皮膚への刺激性および使用感の観点から、低刺激性のものが好ましい。
上記のうちでも、低刺激性のアニオン界面活性剤としては、ヤシ油脂肪酸アシルグルタミン酸ナトリウムなどのＮ−アシルグルタミン酸塩、ラウロイルメチル-β-アラニンナトリウム、ヤシ油脂肪酸メチルアラニンナトリウムなどのＮ−アシルメチルアラニン塩、ヤシ油脂肪酸メチルタウリンナトリウム、ラウロイルメチルタウリンナトリウムなどのＮ−アシルメチルタウリン塩、ラウロイルサルコシンナトリウム、ヤシ油脂肪酸サルコシンナトリウムなどのＮ−アシルサルコシン塩、ラウロイルアスパラギン酸ナトリウムなどのＮ−アシルアスパラギン酸塩、ラウレス硫酸ナトリウムなどが挙げられる。
The surfactant is preferably a mild one from the viewpoint of skin irritation and feeling of use.
Among the above-mentioned, as a hypoallergenic anionic surfactant, N-acyl glutamate such as coconut oil fatty acid acyl glutamate sodium, N-acyl methyl such as lauroyl methyl-β-alanine sodium, coconut oil fatty acid methylalanine sodium etc. Alanine salt, coconut oil fatty acid methyl taurine sodium, N-acyl methyl taurine salt such as sodium lauroyl methyl taurine, lauroyl sarcosine sodium, coconut oil fatty acid sodium sarcosine N-acyl sarcosine salt, sodium lauroyl aspartate such as sodium lauroyl aspartate Acid salts, sodium laureth sulfate and the like.
低刺激性の両性界面活性剤としては、ラウリルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピルベタインなどのアミノ酢酸ベタイン型両性界面活性剤（ラウリン酸アミドプロピルベタインなど）、２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインなどのイミダゾリン型両性界面活性剤などが挙げられる。 As hypoallergenic amphoteric surfactants, aminoacetic acid betaine type amphoteric surfactants such as lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine (such as lauric amidopropyl betaine), 2-alkyl-N-carboxymethyl And imidazoline type amphoteric surfactants such as -N-hydroxyethyl imidazolinium betaine.
また、低刺激性のノニオン界面活性剤としては、ヤシ油脂肪酸モノエタノールアミド、ヤシ油脂肪酸ジエタノールアミド、ヤシ油脂肪酸Ｎ−メチルエタノールアミドなどの脂肪酸アルカノールアミド、モノオレイン酸ポリオキシエチレンソルビタンなどのポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンラウリルエーテルが挙げられる。 In addition, as non-irritant nonionic surfactants, fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide, coconut oil fatty acid N-methylethanolamide, and polys such as polyoxyethylene sorbitan monooleate Oxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene lauryl ether may be mentioned.
界面活性剤は、水などで希釈されて市販される場合があるが、本明細書において（Ｃ）界面活性剤としての配合量は、特に断りのない限り界面活性剤そのものの洗浄用組成物全量に対する質量％として示される。（Ｃ）界面活性剤は、通常、５〜５０質量％程度、好ましくは５〜３０質量％、より好ましくは１０〜３０質量％、さらに好ましくは１５〜２５質量％である。 The surfactant may be diluted with water or the like to be marketed, but in the present specification, the compounding amount as (C) surfactant is the total amount of the cleaning composition for the surfactant itself unless otherwise noted. It is shown as mass% to. The amount of the surfactant (C) is usually about 5 to 50% by mass, preferably 5 to 30% by mass, more preferably 10 to 30% by mass, and still more preferably 15 to 25% by mass.
（Ａ）ミコナゾールまたはその塩を含む洗浄用組成物において、（Ｃ）界面活性剤は、上記の低刺激性のアニオン界面活性剤と低刺激性の両性界面活性剤との組合せが好ましい。その配合比は特に限定されないが、例えば、アニオン界面活性剤：両性界面活性剤＝１：０.１〜５、好ましくは１：０．３〜４、より好ましくは１：０．５〜２、とりわけ好ましくは１：０．５〜１とすることができる。 In the cleaning composition containing (A) miconazole or a salt thereof, the (C) surfactant is preferably a combination of the above-mentioned mild stimulus anionic surfactant and a mild stimulus amphoteric surfactant. The compounding ratio is not particularly limited, but, for example, anionic surfactant: amphoteric surfactant = 1: 0.1-5, preferably 1: 0.3-4, more preferably 1: 0.5-2 Most preferably, it can be 1: 0.5-1.
溶解性が低い（Ａ）ミコナゾールまたはその塩を完全に溶解するかまたは均一に分散するに際して、上記好ましい界面活性剤の組合せは、この抗真菌剤の有効成分を完全に溶解した洗浄用組成物を得ることができる。 When completely dissolving or uniformly dispersing the poorly soluble (A) miconazole or a salt thereof, the combination of the above-mentioned preferred surfactants results in a cleaning composition in which the active ingredient of the antimycotic agent is completely dissolved. You can get it.
本発明に係る洗浄用組成物は、上記（Ａ）〜（Ｃ）に加え、本発明の効果を損なわない範囲で、他の成分を配合することができる。
他の成分としては、たとえば（Ａ）ミコナゾールまたはその塩の析出の抑制などのために、炭素数３〜８の少なくとも一つのアルカンジオールを配合することができる。炭素数３〜８のアルカンジオールとしては、ブタンジオール、プロパンジオール（１，３−プロパンジオール、１，２−プロパンジオール）、ペンタンジオール、ヘキサンジオールまたはオクタンジオールなどが挙げられる。好ましくは炭素数３〜５のアルカンジオールであり、特に好ましくは１，３−ブタンジオール（１，３−ブチレングリコール）、１，２−プロパンジオール（プロピレングリコール）である。
上記アルカンジオールの配合量は特に限定されないが、組成物全量に対して、０.１〜１５質量％が好ましく、１.０〜１０質量％がより好ましい。
In addition to said (A)-(C), the composition for washing | cleaning which concerns on this invention can mix | blend another component in the range which does not impair the effect of this invention.
As another component, at least one alkanediol having 3 to 8 carbon atoms can be blended, for example, to suppress precipitation of (A) miconazole or a salt thereof. Examples of the alkanediol having 3 to 8 carbon atoms include butanediol, propanediol (1,3-propanediol, 1,2-propanediol), pentanediol, hexanediol or octanediol. It is preferably an alkanediol having 3 to 5 carbon atoms, and particularly preferably 1,3-butanediol (1,3-butylene glycol) or 1,2-propanediol (propylene glycol).
Although the compounding quantity of the said alkanediol is not specifically limited, 0.1-15 mass% is preferable with respect to the composition whole quantity, and 1.0-10 mass% is more preferable.
また他の成分として、トリクロサン、イソプロピルメチルフェノール、トリクロロカルバニリド、トリクロロヒドロキシジフェニルエーテル、塩化ベンザルコニウム、レゾルシン、臭化アルキルイソキノリニウム液などの抗菌剤、ジンクピリチオン、二硫化セレン、イオウ、サリチル酸とその塩、ピロクトンオラミンなどの他のふけ防止剤、グリチルリチン酸ジカリウム、グリチルレチン酸ステアリル、アラントインなどの抗炎症剤など、他の有効成分を適宜に配合することもできる。 Further, as other components, antibacterial agents such as triclosan, isopropylmethylphenol, trichlorocarbanilide, trichlorohydroxydiphenyl ether, benzalkonium chloride, resorcinol, alkyl isoquinolinium bromide solution, zinc pyrithione, selenium disulfide, sulfur, salicylic acid Other active ingredients such as salts thereof, other antidandruff agents such as piroctone olamine, and anti-inflammatory agents such as dipotassium glycyrrhizinate, stearyl glycyrrhetinate, allantoin, and the like can also be appropriately blended.
さらに、本発明に係る洗浄用組成物は、他の成分として、一般的に洗浄用組成物に用いられる成分、たとえば色素、顔料などの着色剤、セルロース誘導体、ポリエチレングリコール、カルボキシビニルポリマーなどの粘度調整剤、ベヘニルアルコールやステアリルアルコールなどの高級アルコール、ジステアリン酸グリコール、ジステアリン酸エチレングリコールなどのパール光沢付与剤、クエン酸、クエン酸ナトリウム、安息香酸ナトリウム、コハク酸一ナトリウム、水酸化カリウムなどのｐＨ調節剤、塩化ナトリウムなどの塩類、植物エキス類、植物油、清涼剤、パラオキシ安息香酸メチル、パラオキシ安息香酸プロピルなどの防腐剤、ビタミン剤、香料、オキシベンゾンなどの紫外線吸収剤、アミノ酸、糖などの湿潤剤、グリセリン、濃グリセリン、ソルビトールなどの保湿剤、エデト酸塩などのキレート剤、カチオン性ポリマー（ポリクオタニウム−１０、グアーヒドロキシプロピルトリモニウムクロリド）、シリコーンオイル（ジメチコン）などのコンディショニング成分、エタノール、水などを適宜配合することができる。 Furthermore, the cleaning composition according to the present invention may contain, as another component, a component generally used in a cleaning composition, such as a colorant such as a dye or a pigment, a viscosity of a cellulose derivative, polyethylene glycol or carboxyvinyl polymer. Adjusters, higher alcohols such as behenyl alcohol and stearyl alcohol, pearl brighteners such as glycol distearate and ethylene glycol distearate, pH adjustment such as citric acid, sodium citrate, sodium benzoate, monosodium succinate and potassium hydroxide Agents, salts such as sodium chloride, plant extracts, vegetable oils, cooling agents, preservatives such as methyl parahydroxybenzoate and propyl parahydroxybenzoate, vitamins, fragrances, ultraviolet absorbers such as oxybenzone, wetting agents such as amino acids and sugars , Glycerin, Appropriately blended with moisturizers such as glycerin and sorbitol, chelating agents such as edetate, cationic polymers (polyquaternium-10, guar hydroxypropyltrimonium chloride), conditioning components such as silicone oil (dimethicone), ethanol, water, etc. be able to.
本発明において、洗浄用組成物とは、適用部位の汚れを取り除く、および／または抗真菌作用を発揮することを目的とする組成物であり、洗浄剤成分を配合し、使用後に流水等で洗い流す、ふき取るなど、どのような形態で使用されてもよい。
本発明に係る洗浄用組成物は、医薬品、医薬部外品または化粧品用の洗浄用組成物であり、剤型としては、軟膏、クリーム、乳液、ローション、液剤、エアゾールなどが可能である。その具体的な形態としては、特に限定されないが、たとえば、石鹸（固形石鹸、液体石鹸、泡状石鹸、ボディソープ（ボディシャンプーともいう）、ハンドソープ等）、クレンジング剤（メイク落とし）、シャンプー（頭髪用シャンプー、ドライシャンプー、リンスインシャンプー等）、リンス（ヘアリンス、ヘアコンディショナー等）などが挙げられる。
これらの中でも石鹸、シャンプーが好ましく、とりわけ、シャンプーが好ましい。
また、本発明に係る洗浄用組成物を清浄綿に染み込ませて、ふき取りに使用することもできる。
本発明の洗浄用組成物は、手足など皮膚の洗浄、洗髪など、人の身体に適用できるだけでなく、ペットの全身の洗浄用などあらゆる動物に対して好適に用いることができる。食器、医療器具等の洗浄にも用いることができる。
In the present invention, the cleaning composition is a composition intended to remove stains on the application site and / or exert an antimycotic action, and is formulated with a detergent component and washed away with running water after use. It may be used in any form, such as wiping off.
The cleaning composition according to the present invention is a cleaning composition for medicines, quasi-drugs or cosmetics, and can be in the form of ointment, cream, emulsion, lotion, solution, aerosol or the like. The specific form thereof is not particularly limited, but, for example, soap (solid soap, liquid soap, foamy soap, body soap (also referred to as body shampoo), hand soap etc.), cleansing agent (make-up remover), shampoo ( Hair shampoos, dry shampoos, rinse-in shampoos, etc.), rinses (hair rinses, hair conditioners, etc.) and the like.
Among these, soap and shampoo are preferable, and in particular, shampoo is preferable.
In addition, the cleaning composition according to the present invention can be impregnated in clean cotton and used for wiping.
The cleaning composition of the present invention can be applied not only to the human body, such as cleansing the skin such as hands and feet, and hair washing, but can also be suitably used for all animals such as for cleansing the entire body of a pet. It can also be used to wash dishes and medical instruments.
本発明の洗浄用組成物の好ましい態様例として、たとえば
（Ａ）ミコナゾール硝酸塩を０.１〜１.０質量％、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤を０．１〜２．０質量％、
（Ｃ）ラウロイルメチル-β-アラニンナトリウムを１０〜２０質量％、
２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインを５〜１５質量％、
プロピレングリコールを１．０〜１０質量％、
カチオン性ポリマーを０．２〜１．０質量％、ならびに
ｐＨ調整剤、防腐剤および水を、それぞれ、適量、または上記質量％の残部、
含む洗浄用組成物が挙げられる。
As a preferred embodiment of the cleaning composition of the present invention, for example, 0.1 to 1.0% by mass of (A) miconazole nitrate,
(B) 0.1 to 2.0% by mass of at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract,
(C) 10 to 20% by mass of lauroylmethyl-β-alanine sodium,
5 to 15% by mass of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine,
1.0 to 10 mass% of propylene glycol,
0.2 to 1.0% by mass of a cationic polymer, and an appropriate amount of the pH adjuster, a preservative and water, or the balance of the above mass%,
And cleaning compositions that contain it.
また、
（Ａ）ミコナゾール硝酸塩を０.１〜１.０質量％、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤を０．１〜２．０質量％、
（Ｃ）ラウロイルメチル-β-アラニンナトリウムおよび／またはヤシ油脂肪酸メチルタウリンナトリウムを５〜１５質量％、好ましくは６〜１２質量％、
（Ｄ）任意で２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインおよび／またはヤシ油脂肪酸アミドプロピルベタインを１〜１０質量％、好ましくは２．９〜９質量％、
プロピレングリコールを１．０〜１０質量％、ならびに
ｐＨ調整剤、防腐剤および水を、それぞれ、適量、または上記質量％の残部、
含む洗浄用組成物が挙げられる。
Also,
(A) 0.1 to 1.0% by mass of miconazole nitrate,
(B) 0.1 to 2.0% by mass of at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract,
(C) 5 to 15% by mass, preferably 6 to 12% by mass, of lauroyl methyl-β-alanine sodium and / or coconut oil fatty acid methyltaurine sodium
(D) 1 to 10% by mass, preferably 2.9 to 9% by mass, of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and / or coconut oil fatty acid amidopropyl betaine optionally
1.0 to 10% by mass of propylene glycol, and an appropriate amount of the pH adjuster, the preservative and the water, or the balance of the above-mentioned% by mass,
And cleaning compositions that contain it.
また、
（Ａ）ミコナゾール硝酸塩を０.１〜１.０質量％、
（Ｂ）緑茶乾留エキスを０．１〜２．０質量％、
（Ｃ）ラウロイルメチル-β-アラニンナトリウムおよび／またはヤシ油脂肪酸メチルタウリンナトリウムを５〜１５質量％、好ましくは６〜１２質量％、
（Ｄ）任意で２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインおよび／またはヤシ油脂肪酸アミドプロピルベタインを１〜１０質量％、好ましくは２．９〜９質量％、
プロピレングリコールを１．０〜１０質量％、ならびに
ｐＨ調整剤、防腐剤および水を、それぞれ、適量、または上記質量％の残部、
含む洗浄用組成物が挙げられる。
Also,
(A) 0.1 to 1.0% by mass of miconazole nitrate,
(B) 0.1 to 2.0% by mass of green tea distilled extract,
(C) 5 to 15% by mass, preferably 6 to 12% by mass, of lauroyl methyl-β-alanine sodium and / or coconut oil fatty acid methyltaurine sodium
(D) 1 to 10% by mass, preferably 2.9 to 9% by mass, of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and / or coconut oil fatty acid amidopropyl betaine optionally
1.0 to 10% by mass of propylene glycol, and an appropriate amount of the pH adjuster, the preservative and the water, or the balance of the above-mentioned% by mass,
And cleaning compositions that contain it.
以下に、本発明の実施例を示すが、これら実施例は本発明を具体的に説明するためのものであって、本発明の範囲を限定するものではない。
（実施例１〜２０および比較例１〜２）
全体で１００質量％となる表１に示す各成分を混合し、８０℃に加熱溶解し、撹拌しながら３５℃まで冷却して表１、２に示す組成の洗浄用組成物を調製した。
Examples of the present invention are shown below, but these examples are for the purpose of illustrating the present invention, and do not limit the scope of the present invention.
(Examples 1-20 and comparative examples 1-2)
Each component shown in Table 1 to be 100 mass% in total was mixed, heated and dissolved at 80 ° C., and cooled to 35 ° C. with stirring to prepare a cleaning composition having the composition shown in Tables 1 and 2.
（試験例１）
上記で得られた実施例１〜９および比較例１〜２の各組成物について、以下の加速試験を行い、有効成分の試験前後の含量を定量し、試験前の含量定量値に対する試験後の含量定量値の割合（％）を求めることで安定性を調べた。結果を表３に示す。
加速試験方法：ミコナゾール硝酸塩の吸着や水分蒸発のない容器に調製組成物を入れ、温度４０℃・湿度７５％の恒温恒湿槽に保管し、２ヶ月後にサンプリングを行った。
含量測定方法：以下の条件で高速液体クロマトグラフィーにより定量した。
検出器：紫外吸光光度計（測定波長：２３０nm）
カラム：オクタデシルシリル化シリカゲルカラム
カラム温度：４０℃付近の一定温度
移動相：メタノール／０．０５mol/Lリン酸二水素アンモニウム溶液混液（４：１）
(Test Example 1)
The following accelerated test is performed on each composition of Examples 1 to 9 and Comparative Examples 1 to 2 obtained above to determine the content before and after the test of the active ingredient, and the content after the test for the content quantitative value before the test is determined. The stability was examined by determining the percentage of the content quantitative value. The results are shown in Table 3.
Accelerated test method: The prepared composition was placed in a container without adsorption of miconazole nitrate or evaporation of water, stored in a constant temperature and humidity chamber with a temperature of 40 ° C. and a humidity of 75%, and sampled after 2 months.
Content measurement method: It quantified by high performance liquid chromatography on condition of the following.
Detector: Ultraviolet absorptiometer (measurement wavelength: 230 nm)
Column: Octadecylsilylated silica gel column Column temperature: Constant temperature around 40 ° C Mobile phase: Methanol / 0.05 mol / L ammonium dihydrogen phosphate solution mixture (4: 1)
表に示すとおり、比較例の組成物では、試験期間２ケ月で有効成分ミコナゾール硝酸塩の明らかな含量低下が認められるのに対し、本発明で特定される（Ｂ）抗酸化剤の配合により該含量低下の抑制効果が認められた。 As shown in the table, in the composition of the comparative example, a clear decrease in the content of the active ingredient miconazole nitrate is observed in 2 months of the test period, while the content according to the composition of the (B) antioxidant specified in the present invention The reduction effect was recognized.
（実施例２−１〜２−２、比較例２−１〜２−３）
実施例１等の方法に準じ、表４に示す組成の洗浄用組成物を調製した。
(Examples 2-1 to 2-2, Comparative examples 2-1 to 2-3)
A cleaning composition having the composition shown in Table 4 was prepared according to the method of Example 1 and the like.
（試験例２）豚皮を用いた不快臭抑制効果の確認
＜試験方法＞
豚皮（Ｙｕｃａｔａｎ ｍｉｃｒｏｐｉｇ ｓｋｉｎ ｓｅｔ 日本チャールス・リバー（株））について皮下脂肪を除去する前処理を行い、５×５ｃｍとした。
前処理した豚皮を生理食塩水に１時間以上浸漬した後、ワイパーにて軽く水切りし、表面に下記のいずれかの不快臭源を滴下した。不快臭源が内側となるよう２つ折りとし、１分間放置し不快臭を染み込ませた。
実施例２−１〜２−２の洗浄用組成物、比較例２−１〜２−２、または比較例２−３の組成物（比較例２−３は、トリクロサンを含む一般的な薬用洗浄剤であり、ミコナゾールを含まない）３０ｇをφ９０ｍｍシャーレにとり、その中に豚皮を１分間浸漬した。３Ｌの水で３０秒間すすいだ後、軽く水気を切り、３５０ｍＬガラス密閉容器に入れた。対象は洗浄用組成物３０ｇに代えて水を使用し、後は同じ処理とした。
＜評価方法＞
豚皮を入れた３５０ｍＬ密閉容器を４０℃３０分加温後、容器内のヘッドスペース中の不快臭濃度を下記定量方法で測定した。各組成物による不快臭の除去率は下記式により求めた。結果を表５〜６に示す。
除去率（％）＝（対照のガス濃度（ｐｐｍ）−組成物を使用したときのガス濃度（ｐｐｍ））／（対照のガス濃度（ｐｐｍ）））
＜測定方法＞
４種の不快臭源について、それぞれ以下の方法によりガス濃度を求めた。
ノネナール ガスクロマトグラフィー法
ガスクロマトグラフ：ＧＣ−２０１４（（株）島津製作所）
検出器：ＦＩＤ（（株）島津製作所）
カラム：Ｔｈｅｒｍｏｎ−３０００ ５％ ＳｈｉｎｃａｒｂｏｎＡ ６０／８０ ３ｍｍ×２．１ｍ（信和化工（株））
カラム温度：１３０℃付近の一定温度
ＩＮＪ．Ｔ／ＤＥＴ.Ｔ：１８０℃／１８０℃
注入量：１ｍＬ
ｉ−吉草酸 ガス検知管法（８Ｌ）
メチルメルカプタン ガス検知管法（７Ｌ）
アンモニア ガス検知管法（３Ｍ、３Ｌ）
(Test Example 2) Confirmation of unpleasant odor suppressing effect using pig skin <Test method>
The pig skin (Yucatan micropig skin set Japan Charles River Co., Ltd.) was pretreated to remove subcutaneous fat to a size of 5 × 5 cm.
After the pretreated pig skin was immersed in physiological saline for 1 hour or more, it was lightly drained with a wiper, and any of the following unpleasant odor sources were dropped on the surface. It was folded in two so that the unpleasant odor source was inside, and left for 1 minute to soak in the unpleasant odor.
Composition for cleaning of Examples 2-1 to 2-2, composition of Comparative examples 2-1 to 2-2, or Comparative example 2-3 (Comparative example 2-3 is a general pharmaceutical cleaning containing triclosan Agent (not containing miconazole) was placed in a .phi.90 mm petri dish, and the pig skin was immersed therein for 1 minute. After rinsing with 3 L of water for 30 seconds, lightly drained and placed in a 350 mL glass closed container. The subject used water instead of 30 g of the cleaning composition, and the same treatment was performed thereafter.
<Evaluation method>
After heating a 350 mL closed container containing pig skin at 40 ° C. for 30 minutes, the unpleasant odor concentration in the head space in the container was measured by the following quantitative method. The removal rate of the unpleasant odor by each composition was calculated | required by the following formula. The results are shown in Tables 5-6.
Removal rate (%) = (gas concentration of control (ppm) -gas concentration when using composition (ppm)) / (gas concentration of control (ppm)))
<Measurement method>
The gas concentration of each of the four unpleasant odor sources was determined by the following method.
Nonenal gas chromatography method Gas chromatograph: GC-2014 (Shimadzu Corporation)
Detector: FID (Shimadzu Corporation)
Column: Thermon-3000 5% Shincarbon A 60/80 3 mm x 2.1 m (Shinwa Chemical Industries, Ltd.)
Column temperature: constant temperature around 130 ° C. INJ. T / DET.T: 180 ° C / 180 ° C
Injection volume: 1 mL
i-Valeric acid gas detection tube method (8 L)
Methyl mercaptan gas detector tube method (7 L)
Ammonia gas detector tube method (3M, 3L)
表５に示す通り、不快臭源がノネナールの場合、一般的な薬用洗浄剤である比較例２−３が除去率１２．２％と低いのに対し、ミコナゾールを含む比較例２−１は５５．７％と除去率が大幅に改善し、さらに緑茶乾留エキスを含む実施例２−１では６６．４％と除去率が更に改善していることが分かる。更に、主な成分の含量の多い比較例２−２および実施例２−２でも同様の傾向がみられ、特に実施例２−２では９２．３％もの高い除去率を示す事が分かる。 As shown in Table 5, when the unpleasant odor source is nonenal, the removal rate of Comparative Example 2-3, which is a general medicinal detergent, is as low as 12.2%, while Comparative Example 2-1 including miconazole is 55 The removal rate is significantly improved to 7%, and it is further understood that the removal rate is further improved to 66.4% in Example 2-1 including the green tea dry-distilled extract. Furthermore, the same tendency is seen in Comparative Example 2-2 and Example 2-2, which have a large content of main components, and it can be seen that particularly in Example 2-2, a removal rate as high as 92.3% is exhibited.
表６はｉ−吉草酸、メチルメルカプタンおよびアンモニアの各不快臭源での結果を示している。表６でも表５と同様に、緑茶乾留エキスを含む実施例２−１および２−２がそれぞれ比較例２−１および２−２と比べ、高い除去率を示していることが分かる。 Table 6 shows the results with i-valeric acid, methyl mercaptan and ammonia at each unpleasant odor source. Similarly to Table 5, Table 6 also shows that Examples 2-1 and 2-2 containing the green tea dry-distilled extract show high removal rates as compared with Comparative Examples 2-1 and 2-2, respectively.
（試験例３）ヒトによる不快臭抑制効果の確認
ヒトの腕などの任意の場所３ｃｍ×３ｃｍに前記不快臭源を例えば、６段階臭気強度表示法で、臭気強度５に相当する臭いとなるよう塗布する。実施例２−１〜２−２の洗浄用組成物、比較例２−１〜２−３の組成物１ｍＬで洗浄し、乾燥後臭いを官能評価する。
(Test Example 3) Confirmation of unpleasant odor suppressing effect by human: The unpleasant odor source is an odor corresponding to an odor intensity of 5 in the 6-step odor intensity display method, for example, at 3 cm × 3 cm in any place such as human arm. Apply It wash | cleans with 1 mL of the composition for washing | cleaning of Example 2-1 to 2-2, and the composition of Comparative Example 2-1 to 2-3, and sensory evaluation of the smell after drying is carried out.
不快臭源により異なるが、比較例２−１および２−２の組成物は、対照と比べて不快臭抑制効果があることが分かる。さらに、緑茶乾留エキスを含む実施例２−１および２−２では、不快臭源を問わず、高い不快臭抑制効果があることが分かる。これより組成物に緑茶乾留エキスを加えることで、不快臭源を問わず、高い不快臭抑制効果が期待できる。 Although it changes with unpleasant odor sources, it turns out that the composition of Comparative Example 2-1 and 2-2 has an unpleasant odor inhibitory effect compared with a control. Furthermore, in Examples 2-1 and 2-2 containing a green tea dry-distilled extract, it is understood that there is a high unpleasant odor inhibitory effect regardless of the unpleasant odor source. From this, by adding the green tea dry-distilled extract to the composition, a high unpleasant odor inhibitory effect can be expected regardless of the unpleasant odor source.
（試験例４）抗マラセチア効果試験
＜培地作製＞
寒天培地希釈法を用いた。
ミコナゾール硝酸塩、緑茶乾留エキスの各成分、またはこれらの混合物をＤＭＳＯで希釈し、撹拌して洗浄用組成物原液を調製した。調製した組成を表７に示す。これをサブローデキストロース寒天培地（ＳＤＡ）で段階希釈し、２倍希釈系列を調製した。
(Test Example 4) Anti-Malasettia Effect Test <Preparation of Medium>
The agar dilution method was used.
Miconazole nitrate, each component of green tea dry-distilled extract, or a mixture thereof was diluted with DMSO and stirred to prepare a cleaning composition stock solution. The composition prepared is shown in Table 7. This was serially diluted with Sabouraud dextrose agar (SDA) to prepare a 2-fold dilution series.
試験菌（Malassezia furfur）をオリーブオイル添加ＳＤＡに接種し、３０±２℃で７２時間培養した。培養後の菌液を、滅菌生理食塩水を用いて希釈し、菌数が１０６ｃｅｌｌ／ｍＬとなるように調製した。
＜測定方法＞
作製した培地に、調製した菌液を接種し、オリーブオイル添加後、３０±２℃で培養した。７２時間後、試験菌の発育の有無を肉眼で観察し、培地における菌の発育を観察し、３段階で判定した。培地全体に菌の発育を認めるものを「＋」、菌の発育が培地の１／３未満であるものを「±」、培地に菌の発育が認められないものを「−」とした。結果を表８に示す。
The test strain (Malassezia furfur) was inoculated into olive oil-added SDA, and cultured at 30 ± 2 ° C. for 72 hours. The culture broth was diluted with sterile saline to prepare a cell count of 10 6 cells / mL.
<Measurement method>
The prepared culture solution was inoculated with the prepared bacterial solution, added with olive oil, and then cultured at 30 ± 2 ° C. After 72 hours, the presence or absence of the growth of the test bacteria was visually observed, and the growth of the bacteria in the culture medium was observed and judged in three steps. Those showing growth of bacteria in the whole culture were regarded as "+", those with growth of bacteria less than 1/3 of the culture medium as "±", and those without growth of bacteria in the medium were regarded as "-". The results are shown in Table 8.
比較例３−１はミコナゾール硝酸塩の処方であり、表８より試験菌の最小発育阻止濃度（ＭＩＣ）が１２５ｐｐｍであることが分かる。比較例３−２は緑茶乾留エキスの処方であるが、表８の結果から明らかなように、緑茶乾留エキス自身には菌の発育を抑制する効果が無いことが分かる。なお比較例３−２では洗浄用組成物成分濃度２０００ｐｐｍにおいても菌の発育を確認している。一方、ミコナゾール硝酸塩と緑茶乾留エキスの両方を含む実施例３−１では、ＭＩＣが比較例３−１よりも低い６２．５ｐｐｍであった。緑茶乾留エキス自身には菌の発育抑制効果が見られないことから、緑茶乾留エキスがミコナゾール硝酸塩の菌発育抑制効果を増強させたものと考えられる。 Comparative Example 3-1 is a formulation of miconazole nitrate, and Table 8 shows that the minimum inhibitory concentration (MIC) of the test bacterium is 125 ppm. Comparative Example 3-2 is a formulation of the green tea dry-distilled extract, but it is clear from the results of Table 8 that the green tea dry-distilled extract itself has no effect of suppressing the growth of bacteria. In Comparative Example 3-2, growth of bacteria was also confirmed at a concentration of 2000 ppm of the composition for cleaning. On the other hand, in Example 3-1 containing both miconazole nitrate and green tea dry-distilled extract, MIC was 62.5 ppm lower than Comparative Example 3-1. It is considered that the green tea dry-distilled extract enhances the bacterial growth-suppressing effect of miconazole nitrate, since the green tea dry-distilled extract itself does not show the growth-inhibiting effect of bacteria.
Claims (16)
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤、ならびに
（Ｃ）界面活性剤
を含有する、医薬品、医薬部外品または化粧品用の洗浄用組成物。 (A) miconazole and / or a salt thereof
Drugs and quasi-drugs comprising (B) at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract, and (C) a surfactant Or a cosmetic composition for cleaning.
Ｎ−アシルグルタミン酸塩、Ｎ−アシルメチルアラニン塩、Ｎ−アシルメチルタウリン塩、Ｎ−アシルサルコシン塩およびＮ−アシルアスパラギン酸塩からなる群より選ばれる少なくとも１種のアニオン界面活性剤、
アミノ酢酸ベタイン型両性界面活性剤および／またはイミダゾリン型両性界面活性剤の両性界面活性剤、ならびに
脂肪酸アルカノールアミド、ポリオキシエチレンソルビタン脂肪酸エステルおよびポリオキシエチレン硬化ヒマシ油からなる群より選ばれる少なくとも１種のノニオン界面活性剤からなる群より選ばれる少なくとも１種である、請求項１または２に記載の洗浄用組成物。 The (C) surfactant is
At least one anionic surfactant selected from the group consisting of N-acyl glutamate, N-acyl methyl alanine salt, N-acyl methyl taurine salt, N-acyl sarcosine salt and N-acyl aspartate,
At least one selected from the group consisting of fatty acid alkanolamide, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene hydrogenated castor oil, and amphoteric surfactant of aminoacetic acid betaine type amphoteric surfactant and / or imidazoline type amphoteric surfactant The cleaning composition according to claim 1 or 2, which is at least one selected from the group consisting of nonionic surfactants.
（Ａ）ミコナゾールおよび／またはその塩を０．１〜２．０質量％、
（Ｂ）抗酸化剤を０．００１〜５．０質量％、ならびに
（Ｃ）界面活性剤を５．０〜５０質量％
含有する、請求項１〜５のいずれか１項に記載の洗浄用組成物。 With respect to the total amount of the composition,
(A) 0.1 to 2.0% by mass of miconazole and / or a salt thereof,
(B) 0.001 to 5.0% by mass of an antioxidant, and (C) 5.0 to 50% by mass of a surfactant
The cleaning composition according to any one of claims 1 to 5, which contains it.
（Ａ）ミコナゾール硝酸塩を０．１〜１．０質量％、
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤を０．１〜２．０質量％、ならびに
（Ｃ）Ｎ−アシルグルタミン酸塩、Ｎ−アシルメチルアラニン塩、Ｎ−アシルメチルタウリン塩、Ｎ−アシルサルコシン塩およびＮ−アシルアスパラギン酸塩からなる群より選ばれる少なくとも１種のアニオン界面活性剤、および／またはアミノ酢酸ベタイン型両性界面活性剤、および／またはイミダゾリン型両性界面活性剤の両性界面活性剤を１０〜３０質量％
を含有する、請求項１〜９のいずれか１項に記載の洗浄用組成物。 With respect to the total amount of the composition,
(A) 0.1 to 1.0% by mass of miconazole nitrate,
(B) 0.1 to 2.0% by mass of at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract, and (C) N-acyl At least one anionic surfactant selected from the group consisting of glutamate, N-acylmethylalanine salt, N-acylmethyl taurine salt, N-acyl sarcosine salt and N-acyl aspartate salt, and / or betaine aminoacetate Type of amphoteric surfactant and / or 10 to 30% by mass of amphoteric surfactant of imidazoline type amphoteric surfactant
The cleaning composition according to any one of claims 1 to 9, which comprises
前記両性界面活性剤が、ラウリルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピルベタインおよび２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインからなる群より選ばれる少なくとも１種である、請求項１０に記載の洗浄用組成物。 The said anionic surfactant is coconut oil fatty acid acyl sodium glutamate, lauroyl methyl-β-alanine sodium, coconut oil fatty acid methylalanine sodium, coconut oil fatty acid methyl taurine sodium, lauroyl methyl taurine sodium, lauroyl sarcosine sodium, coconut oil fatty acid sarcosine sodium And at least one selected from the group consisting of sodium lauroyl aspartate, and
The amphoteric surfactant is at least one selected from the group consisting of lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. 11. The cleaning composition according to item 10.
（Ｂ）緑茶乾留エキスを０．１〜２．０質量％、
（Ｃ）ラウロイルメチル-β-アラニンナトリウムおよび／またはヤシ油脂肪酸メチルタウリンナトリウムを５〜１５質量％
（Ｄ）任意で２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインおよび／またはヤシ油脂肪酸アミドプロピルベタインを１〜１０質量％、
プロピレングリコールを１．０〜１０質量％、ならびに
ｐＨ調整剤、防腐剤および水を
含むシャンプーまたは石けんである、洗浄用組成物。 (A) 0.1 to 1.0% by mass of miconazole nitrate,
(B) 0.1 to 2.0% by mass of green tea distilled extract,
(C) 5 to 15 mass% of lauroyl methyl-β-alanine sodium and / or coconut oil fatty acid methyl taurine sodium
(D) optionally 1 to 10% by weight of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and / or coconut oil fatty acid amidopropyl betaine,
A cleaning composition which is 1.0 to 10% by mass of propylene glycol, and a shampoo or soap containing a pH adjuster, a preservative and water.
（Ｂ）緑茶乾留エキスと、
（Ｃ）界面活性剤とを含有する体臭抑制剤。 (A) miconazole and / or a salt thereof
(B) Green tea dry distilled extract,
(C) A body odor inhibitor containing a surfactant.
（Ｂ）緑茶乾留エキスを０．１〜２．０質量％、
（Ｃ）ラウロイルメチル-β-アラニンナトリウムおよび／またはヤシ油脂肪酸メチルタウリンナトリウムを５〜１５質量％
（Ｄ）任意で２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインおよび／またはヤシ油脂肪酸アミドプロピルベタインを１〜１０質量％、
プロピレングリコールを１．０〜１０質量％、ならびに
ｐＨ調整剤、防腐剤および水を
含むシャンプーまたは石けんである、体臭抑制用組成物。 (A) 0.1 to 1.0% by mass of miconazole nitrate,
(B) 0.1 to 2.0% by mass of green tea distilled extract,
(C) 5 to 15 mass% of lauroyl methyl-β-alanine sodium and / or coconut oil fatty acid methyl taurine sodium
(D) optionally 1 to 10% by weight of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and / or coconut oil fatty acid amidopropyl betaine,
A composition for controlling body odor which is a shampoo or a soap containing 1.0 to 10% by mass of propylene glycol, and a pH adjuster, a preservative and water.
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤からなる前記（Ａ）ミコナゾールおよび／またはその塩の安定化剤。 For blending into a cleaning composition comprising (A) miconazole and / or a salt thereof, and (C) a surfactant,
(B) A stabilizer for miconazole (A) and / or a salt thereof, which comprises at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, green tea distilled extract and tea extract.
（Ｂ）ピロ亜硫酸ナトリウム、トコフェロール、天然ビタミンＥ、緑茶乾留エキスおよび茶エキスからなる群より選ばれる少なくとも１種の抗酸化剤、ならびに（Ｃ）界面活性剤
を配合してなる、医薬品、医薬部外品または化粧品用の洗浄用組成物。 (A) miconazole and / or a salt thereof
(B) Pharmaceutical, pharmaceutical part comprising a combination of at least one antioxidant selected from the group consisting of sodium pyrosulfite, tocopherol, natural vitamin E, green tea dry extract and tea extract, and (C) surfactant Cleaning composition for external products or cosmetics.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020218116A1 (en) | 2019-04-23 | 2020-10-29 | 矢崎総業株式会社 | Vehicle antenna |
| CN114939074A (en) * | 2022-04-02 | 2022-08-26 | 深圳市仙迪化妆品股份有限公司 | Anti-dandruff and odor-removing cleaning composition and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06508748A (en) * | 1991-06-20 | 1994-10-06 | カラマズー ホルディングス，インコーポレーテッド | Suspensions of ascorbic acid particles of micron order and their use as antioxidants |
| WO2004028502A1 (en) * | 2002-09-27 | 2004-04-08 | Mochida Pharmaceutical Co., Ltd. | Cleansing composition containing antifungal agent and antibacterial agent |
| JP2004269419A (en) * | 2003-03-07 | 2004-09-30 | Mochida Pharmaceut Co Ltd | Aqueous injection containing miconazole |
| JP2007238597A (en) * | 2006-02-08 | 2007-09-20 | Kose Corp | Skin care preparation |
| JP2008024686A (en) * | 2006-07-25 | 2008-02-07 | Lion Corp | Hair cosmetic composition |
| JP2010275198A (en) * | 2009-05-26 | 2010-12-09 | Mochida Pharmaceut Co Ltd | Composition for cleaning |
| JP2011519969A (en) * | 2008-05-12 | 2011-07-14 | タグラ バイオテクノロジーズ リミテッド | Composition for topical application comprising a microencapsulated colorant |
-
2018
- 2018-12-27 JP JP2018245901A patent/JP6837470B2/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06508748A (en) * | 1991-06-20 | 1994-10-06 | カラマズー ホルディングス，インコーポレーテッド | Suspensions of ascorbic acid particles of micron order and their use as antioxidants |
| WO2004028502A1 (en) * | 2002-09-27 | 2004-04-08 | Mochida Pharmaceutical Co., Ltd. | Cleansing composition containing antifungal agent and antibacterial agent |
| JP2004269419A (en) * | 2003-03-07 | 2004-09-30 | Mochida Pharmaceut Co Ltd | Aqueous injection containing miconazole |
| JP2007238597A (en) * | 2006-02-08 | 2007-09-20 | Kose Corp | Skin care preparation |
| JP2008024686A (en) * | 2006-07-25 | 2008-02-07 | Lion Corp | Hair cosmetic composition |
| JP2011519969A (en) * | 2008-05-12 | 2011-07-14 | タグラ バイオテクノロジーズ リミテッド | Composition for topical application comprising a microencapsulated colorant |
| JP2010275198A (en) * | 2009-05-26 | 2010-12-09 | Mochida Pharmaceut Co Ltd | Composition for cleaning |
Non-Patent Citations (1)
| Title |
|---|
| 日本化粧品技術者会 編, 化粧品事典, JPN6018017850, 15 December 2003 (2003-12-15), pages 459 - 460, ISSN: 0004322076 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020218116A1 (en) | 2019-04-23 | 2020-10-29 | 矢崎総業株式会社 | Vehicle antenna |
| CN114939074A (en) * | 2022-04-02 | 2022-08-26 | 深圳市仙迪化妆品股份有限公司 | Anti-dandruff and odor-removing cleaning composition and application thereof |
| CN114939074B (en) * | 2022-04-02 | 2023-05-02 | 深圳市仙迪化妆品股份有限公司 | Anti-dandruff and deodorizing cleaning composition and application thereof |
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