CN111773341A - A compound Chinese herbal medicine external preparation for treating scabies of piglets - Google Patents
A compound Chinese herbal medicine external preparation for treating scabies of piglets Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
本发明公开了一种治疗仔猪疥癣病的复方中草药外用制剂，这样制得：分别称取大樱桃叶、花椒、百部、木槿皮、硫磺、明矾和亚麻籽油；分别粉碎大樱桃叶、花椒、百部、木槿皮、硫磺和明矾，混合均匀，加入亚麻籽油，混匀，调为稠膏状，制成治疗仔猪疥癣病的复方中草药外用制剂。该外用制剂采用全天然中草药制成，用于治疗仔猪疥癣病，无毒副作用，安全有效。复方配比，日间+夜间给药涂抹治疗3～5d内痊愈，总有效率达98%以上。The invention discloses a compound Chinese herbal medicine external preparation for treating scabies of piglets. Chinese prickly ash, baibu, hibiscus bark, sulfur and alum are mixed evenly, and linseed oil is added, mixed well, and adjusted into a thick paste to prepare a compound Chinese herbal medicine external preparation for treating scabies of piglets. The external preparation is made of all-natural Chinese herbal medicine, is used for treating piglet mange, has no toxic and side effects, and is safe and effective. Compound formula, daytime + nighttime administration and smearing treatment will heal within 3 to 5 days, and the total effective rate is over 98%.
Description
技术领域technical field
本发明属于中兽医医药技术领域，涉及一种治疗仔猪疥癣病的复方中草药外用制剂。The invention belongs to the technical field of traditional Chinese veterinary medicine, and relates to a compound Chinese herbal medicine external preparation for treating scabies of piglets.
背景技术Background technique
癣候记载：“癣病之状，皮肉隐胗如钱文，渐渐增长，或圆或斜，痒痛有匡郭，如里生虫，搔之有汁”。疥癣病俗称疥疤，是一种慢性皮肤寄生虫病，虫体从卵到成虫的整个发育期约10天左右，生长期较长。仔猪疥癣通常起始于头部、颊及耳部，以后蔓延到背部、躯干两侧及后肢内侧。病猪局部发痒，常以肢搔痒或靠墙角、柱栏等处摩擦。数日后，患部皮肤上出现针头大小的结节，随后形成水疱或脓疱。当水疱及脓疱破溃后，结成痂皮。病情严重时体毛脱落。皮肤的角质化程度增强，干枯，出现皱纹或龟裂，食欲减退，生长停滞，逐渐消瘦，甚至死亡。仔猪体弱，此病为接触传染，反复性比较强，因此必须采取有效的防治措施。目前，治疗仔猪疥癣病的药物及方法较多，常用速灭杀丁、敌杀死、林丹乳油、敌百虫等，或甚至有用六六粉等禁用药品治疗，但这些药物存在毒副作用大，由于仔猪的舔舐引起中毒的问题。多数西药治疗后虽能很快见效，但停药后易于复发、副作用大、难以根除。中医认为体癣为风湿邪气，客于腠理，或因接触不洁之物而发病。因此，需要制备一种疗效高，安全可靠，价格低廉，使用方便的治疗仔猪疥癣病的天然药物。Ringworm waiting records: "The symptoms of ringworm disease, the skin and flesh are hidden like money, and gradually grow, either round or oblique, itching and tingling, like worms, and juicy when scratched." Scabies, commonly known as scabies, is a chronic skin parasitic disease. The whole development period of the worm from egg to adult is about 10 days, and the growth period is longer. Piglet mange usually begins on the head, cheeks, and ears, and later spreads to the back, sides of the trunk, and the inside of the hind limbs. Sick pigs are itchy locally, often with limbs itching or rubbing against corners, columns and other places. After a few days, pinhead-sized nodules appear on the affected skin, followed by blisters or pustules. When the blisters and pustules burst, crusts form. Body hair sheds in severe cases. Increased keratinization of the skin, dryness, wrinkles or cracks, loss of appetite, stagnation of growth, gradual weight loss, and even death. Piglets are weak, the disease is contagious, and the recurrence is relatively strong, so effective prevention and control measures must be taken. At present, there are many drugs and methods for treating scabies in piglets, such as quick sterilization, dichloride, lindane EC, trichlorfon, etc., or even banned drugs such as Liuliu powder, but these drugs have serious toxic and side effects. , problems with poisoning due to licking of piglets. Although most western medicines can be effective soon after treatment, they are prone to relapse after drug withdrawal, with severe side effects and difficult to eradicate. Traditional Chinese medicine believes that tinea corporis is a rheumatic pathogen, which can be caused by contact with unclean things. Therefore, it is necessary to prepare a natural medicine for treating scabies of piglets with high curative effect, safety, reliability, low price and convenient use.
发明内容SUMMARY OF THE INVENTION
本发明的目的是提供一种疗效高、安全可靠、价格低廉、使用方便的治疗仔猪疥癣病的复方中草药外用制剂。The purpose of the present invention is to provide a compound Chinese herbal medicine external preparation for treating scabies of piglets with high curative effect, safety, reliability, low price and convenient use.
为实现上述目的，本发明所采用的技术方案是：一种治疗仔猪疥癣病的复方中草药外用制剂，这样制得：For achieving the above object, the technical scheme adopted in the present invention is: a compound Chinese herbal medicine external preparation for the treatment of piglet scabies, obtained like this:
1）分别称取大樱桃叶50～60g、花椒20～30g、百部10～15g、木槿皮10～15g、硫磺10～15g、明矾4～6g和亚麻籽油80～100g；1) Weigh 50-60g of large cherry leaves, 20-30g of Chinese prickly ash, 10-15g of baibu, 10-15g of hibiscus bark, 10-15g of sulfur, 4-6g of alum and 80-100g of linseed oil;
2）将大樱桃叶、花椒、百部、木槿皮、硫磺和明矾分别粉碎成粒径小于等于90μm的粉末，混合均匀，得混合药粉；2) Pulverize large cherry leaves, Chinese prickly ash, Baibu, hibiscus bark, sulfur and alum into powders with a particle size of less than or equal to 90 μm, and mix them evenly to obtain a mixed medicinal powder;
3）混合药粉中加入亚麻籽油，调成糊状，得稠膏，制成治疗仔猪疥癣病的复方中草药外用制剂。3) Add flaxseed oil to the mixed medicinal powder, adjust it into a paste, obtain a thick paste, and prepare a compound Chinese herbal medicine external preparation for treating scabies of piglets.
本发明复方中草药外用制剂中各组分的药用性能：The medicinal properties of each component in the compound Chinese herbal medicine external preparation of the present invention:
1．大樱桃叶：清热解毒、消肿、止痛、杀菌，除疮毒。1. Big cherry leaf: clearing heat and detoxifying, reducing swelling, relieving pain, sterilizing, and removing sores.
2．花椒：杀菌、消毒、止痛、止痒、消肿。2. Zanthoxylum bungeanum: sterilization, disinfection, pain relief, itching relief, swelling reduction.
3．百部：灭头虱、体虱，治蛲虫病，阴部骚痒。3. Hundreds of Departments: Eliminate head lice and body lice, treat enterobiasis, and genital itching.
4. 木槿皮：杀虫治癣。4. Hibiscus skin: insecticide treatment of ringworm.
5．硫磺：用于疥癣、秃疮，阴疽恶疮。5. Sulfur: used for scabies, bald sores, and malignant sores of gangrene.
6．明矾：解毒杀虫、燥湿止痒。6. Alum: detoxification and insecticide, dampness and itching.
7．亚麻籽油：皮肤癣、湿疹，赋形剂。7. Flaxseed Oil: Ringworm, Eczema, Excipient.
大樱桃叶为蔷薇科植物大樱桃的叶子，“甘，平，无毒”（《本草纲目》）， “味辛苦、性温、无毒，入肝、脾二经，主治温胃，健脾，止血，解毒。治胃寒食积，腹泻，吐血，疮毒”（《本草再新》）。研究发现，大樱桃叶富含抑菌性挥发油、多糖和黄酮类化合物，其提取物对金黄色葡萄球菌和大肠埃希氏杆菌的最小抑菌浓度（MIC）分别为0.1056mg/mL和0.1862mg/mL，50000倍透射电镜观察大樱桃叶提取物对细菌的细胞结构有破坏作用，使细胞膜层次不清，外围有液体溢出，可观察到有缺乏任何细胞内结构的细菌碎片，其抗菌效果显著。利用大樱桃叶杀菌消炎、治疗痈疖等的功效，配以花椒、百部、硫磺、明矾、亚麻籽油等抗菌消炎作用的中草药，复方配伍用于治疗仔猪疥癣病的复方中草药外用制剂。The big cherry leaves are the leaves of the Rosaceae plant, "sweet, flat, non-toxic" ("Compendium of Materia Medica"), "hard in taste, warm in nature, non-toxic, enter the liver and spleen meridians, and treat the stomach and strengthen the spleen. , Hemostasis, detoxification. Treats stomach cold food accumulation, diarrhea, vomiting blood, sore" ("Material Renewal"). The study found that large cherry leaves are rich in bacteriostatic volatile oils, polysaccharides and flavonoids, and the minimum inhibitory concentrations (MICs) of their extracts against Staphylococcus aureus and Escherichia coli were 0.1056mg/mL and 0.1862mg, respectively. /mL, 50,000 times transmission electron microscope observation of large cherry leaf extract has a destructive effect on the cell structure of bacteria, making the cell membrane layer unclear, with liquid overflowing from the periphery, and bacterial fragments lacking any intracellular structure can be observed, and its antibacterial effect is remarkable. . Utilizing the sterilization and anti-inflammatory effects of large cherry leaves and the treatment of carbuncle and furuncle, it is combined with Chinese herbal medicines with antibacterial and anti-inflammatory effects such as prickly ash, baibu, sulfur, alum, and linseed oil.
本发明中草药复方外用制剂根据中兽医医药理论和大樱桃叶等中草药抗菌杀虫的固有属性，进行复方配伍。其中的君药为大樱桃叶，具有杀菌、除疮毒的功效；臣药为花椒、百部和木槿皮，具有清热、止痒、除虱的功效；佐药为硫磺，具有除疥癣、秃疮的功效；使药为明矾，具有解毒杀虫和燥湿止痒的功效。The compound external preparation of Chinese herbal medicine of the invention is compounded according to the theory of traditional Chinese veterinary medicine and the inherent properties of Chinese herbal medicines such as large cherry leaves, which are antibacterial and insecticidal. Among them, the king medicine is big cherry leaf, which has the effect of sterilizing and removing sores; the minister medicine is Chinese prickly ash, Baibu and hibiscus peel, which has the functions of clearing heat, relieving itching and removing lice; the adjuvant is sulfur, which has the functions of removing scabies, The effect of alopecia; the medicine is alum, which has the functions of detoxification, insecticide, dampness and itching.
本发明药物组合具有“抗菌杀虫、解毒止痒”之功效。适应于多种疥癣病的外用治疗，尤其对体癣所致的仔猪皮肤发痒、皮屑增多、发炎等症状效果更为明显。The pharmaceutical combination of the present invention has the effects of "antibacterial and insecticide, detoxification and relieving itching". It is suitable for the topical treatment of various scabies, especially for the symptoms of itchy skin, increased dander, and inflammation of piglets caused by tinea corporis.
本发明复方中草药外用制剂的用法用量：日间用棉签蘸取，外擦患处，一日数次。夜间用棉签蘸取，涂擦患处1次。The usage and dosage of the compound Chinese herbal medicine external preparation of the present invention: dip in a cotton swab during the day, rub the affected area outside, several times a day. Dip it with a cotton swab at night and rub the affected area once.
本发明复方中草药外用制剂采用全天然中草药制成，用于治疗仔猪疥癣病。无毒副作用，安全有效。复方配比，日间+夜间给药涂抹治疗3～5d内痊愈，总有效率达98%以上。The compound Chinese herbal medicine external preparation of the invention is made of all-natural Chinese herbal medicine, and is used for treating piglet scabies. No toxic side effects, safe and effective. Compound formula, daytime + nighttime administration and smearing treatment will heal within 3 to 5 days, and the total effective rate is over 98%.
具体实施方式Detailed ways
为了更好的理解本发明，下面以该药物配方作用于已患疥癣病的仔猪疗效结果，说明其在中草药制药领域中的新用途，其实验方法及结果如下。In order to better understand the present invention, the following uses the medicinal formula to act on piglets suffering from scabies, to illustrate its new use in the field of Chinese herbal medicine, and its experimental method and results are as follows.
实施例1Example 1
分别称取自然干燥的大樱桃叶50g、花椒20g、百部10g、木槿皮10g、硫磺10g、明矾4g和亚麻籽油80g；将大樱桃叶、花椒、百部、木槿皮、硫磺和明矾分别粉碎成粒径小于等于90μm的粉末，混合均匀，加入亚麻籽油，调成稠膏，制成治疗仔猪疥癣病的复方中草药外用制剂。Weigh 50 g of naturally dried large cherry leaves, 20 g of Chinese prickly ash, 10 g of 100 parts, 10 g of hibiscus peel, 10 g of sulfur, 4 g of alum and 80 g of linseed oil; Crushed into powder with a particle size of less than or equal to 90 μm, mixed evenly, added with linseed oil, and adjusted into a thick paste to prepare a compound Chinese herbal medicine external preparation for treating piglet scabies.
疗效对比试验：选取50只已患疥癣病的体重5kg左右的20日龄仔猪，随机分为5组，每组10只，分别用不同治疗制剂进行治疗：第1组，用本发明复方中草药外用制剂进行治疗，只在日间棉签外擦患外3次。第2组，用本发明复方中草药外用制剂进行治疗，只在夜间棉签外擦患外1次。第3组，用本发明复方中草药外用制剂进行治疗，棉签外擦患外，日间3次，夜间1次。第4组，用生药浓度为20%的大樱桃叶水煎剂外擦患外，一日3次。第5组，用自来水涂抹患处，一日3次，作为对照。结果如表1所示。Curative effect comparison test: select 50 20-day-old piglets with a body weight of about 5kg who have suffered from scabies, and are randomly divided into 5 groups, 10 in each group, and are treated with different therapeutic preparations respectively: the first group, with the compound Chinese herbal medicine of the present invention For treatment with topical preparations, only wipe the affected area 3 times with a cotton swab during the day. The second group was treated with the compound Chinese herbal medicine topical preparation of the present invention, and only wiped the affected area once with a cotton swab at night. The third group was treated with the compound Chinese herbal medicine external preparation of the present invention, rubbed with a cotton swab on the outside of the affected area, 3 times during the day and once at night. The fourth group was rubbed with the decoction of large cherry leaves with a concentration of 20% crude drug, 3 times a day. In the fifth group, the affected area was smeared with tap water, 3 times a day, as a control. The results are shown in Table 1.
表1 本发明复方中草药外用制剂对仔猪疥癣病的疗效Table 1 The curative effect of the compound Chinese herbal medicine external preparation of the present invention on scabies of piglets
由表1可知，应用本发明复方中草药外用制剂，日间和夜间均涂抹给药，治疗家仔猪疥癣病治疗效果显著，一般3～5d即可痊愈。As can be seen from Table 1, applying the compound Chinese herbal medicine external preparation of the present invention, smearing and administering both during the day and at night, the therapeutic effect of treating scabies of piglets is remarkable, and generally 3～5d can be cured.
临床疗效：于2019年3月～2020年6月在甘肃省甘谷县旺发猪场治疗患疥癣病的仔猪100余例，用本发明复方中草药外用制剂进行仔猪疥癣病的临床治疗。单独复方配比，日间给药涂抹治疗，6～8d痊愈，总有效率达90%；复方配比，日间+夜间给药涂抹治疗，3～5d痊愈，总有效率达98%以上。综合治疗时间和成本等因素，选5d为一疗程，治疗效果最为显著。Clinical efficacy: From March 2019 to June 2020, more than 100 piglets suffering from scabies were treated in Wangfa Pig Farm, Gangu County, Gansu Province, and the compound Chinese herbal medicine external preparation of the present invention was used for clinical treatment of scabies in piglets. With a single compound formulation, daytime administration and smearing treatment, 6-8d recovery, with a total effective rate of 90%; compound formulation, daytime + nighttime administration and smearing treatment, 3-5d recovery, with a total effective rate of over 98%. Considering factors such as treatment time and cost, 5 days were selected as a course of treatment, and the treatment effect was the most significant.
实施例2Example 2
分别称取自然干燥的大樱桃叶55g、花椒25g、百部12g、木槿皮12g、硫磺12g、明矾5g和亚麻籽油90g；将大樱桃叶、花椒、百部、木槿皮、硫磺和明矾分别粉碎成粒径小于等于90μm的粉末，混合均匀，加入亚麻籽油，调至稠膏，制成治疗仔猪疥癣病的复方中草药外用制剂。Weigh 55 g of naturally dried large cherry leaves, 25 g of Chinese prickly ash, 12 g of 100 parts, 12 g of hibiscus peel, 12 g of sulfur, 5 g of alum, and 90 g of linseed oil; Crushed into powder with a particle size of less than or equal to 90 μm, mixed evenly, added with linseed oil, and adjusted to a thick paste to prepare a compound Chinese herbal medicine external preparation for treating piglet scabies.
实施例3Example 3
分别称取自然干燥的大樱桃叶60g、花椒30g、百部15g、木槿皮15g、硫磺15g、明矾6g和亚麻籽油100g；将大樱桃叶、花椒、百部、木槿皮、硫磺和明矾分别粉碎成粒径小于等于90μm的粉末，混合均匀，加入亚麻籽油，调至稠膏，制成治疗仔猪疥癣病的复方中草药外用制剂。Weigh 60 g of naturally dried large cherry leaves, 30 g of Chinese prickly ash, 15 g of 100 parts, 15 g of hibiscus bark, 15 g of sulfur, 6 g of alum and 100 g of linseed oil; Crushed into powder with a particle size of less than or equal to 90 μm, mixed evenly, added with linseed oil, and adjusted to a thick paste to prepare a compound Chinese herbal medicine external preparation for treating piglet scabies.
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| CN114748590A (en) * | 2022-05-07 | 2022-07-15 | 王志军 | Pesticide for preventing and treating ectoparasites of livestock and poultry and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197657A (en) * | 1997-04-29 | 1998-11-04 | 许达友 | Scabies treating oil preparation |
| CN109464512A (en) * | 2018-12-28 | 2019-03-15 | 鼎正动物药业（天津）有限公司 | It is a kind of for treating the external wash liquid and preparation method thereof of pig scabies |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197657A (en) * | 1997-04-29 | 1998-11-04 | 许达友 | Scabies treating oil preparation |
| CN109464512A (en) * | 2018-12-28 | 2019-03-15 | 鼎正动物药业（天津）有限公司 | It is a kind of for treating the external wash liquid and preparation method thereof of pig scabies |
Non-Patent Citations (1)
| Title |
|---|
| 杨浩: "吮乳仔猪疥癣病的治疗", 《中兽医医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114748590A (en) * | 2022-05-07 | 2022-07-15 | 王志军 | Pesticide for preventing and treating ectoparasites of livestock and poultry and preparation method thereof |
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