CN105997539A - Anti-inflammatory and analgesic traditional Chinese medicinal toothpaste - Google Patents
Anti-inflammatory and analgesic traditional Chinese medicinal toothpaste Download PDFInfo
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- CN105997539A CN105997539A CN201610368248.2A CN201610368248A CN105997539A CN 105997539 A CN105997539 A CN 105997539A CN 201610368248 A CN201610368248 A CN 201610368248A CN 105997539 A CN105997539 A CN 105997539A
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- chinese medicinal
- medicinal toothpaste
- borneolum syntheticum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention relates to an anti-inflammatory and analgesic traditional Chinese medicinal toothpaste. The traditional Chinese medicinal toothpaste is characterized in that in every 100g of the traditional Chinese medicinal toothpaste, the content of borax is 0.3-4g and the content of borneol is 0.06-4g. The traditional Chinese medicinal toothpaste disclosed by the invention is significant in anti-inflammatory and analgesic effects.
Description
Invention field
The present invention relates to tooth goods, this tooth goods contain organic compound, the advantage with anti-inflammatory analgesic.
Technical background
The people that odontopathy is suffered from by the world today is a lot, has the toothache of acute gingivitis, apicitis, acute pulpitis etc., can cause
Toothache, the symptom such as red swelling of gingiva, the one of pain during wherein acute pulpitis is toothache, pain spot is obvious, and gingiva can occur
Swelling, tooth completely can not laboratory rodent chow, antibiotic medicine to be used and analgesic control toothache.Borax external heat-clearing and toxic substances removing, controls pharynx
Larynx swells and ache, aphtha of the mouth and tongue, cataract, removing heat from the lung and dissipating phlegm for oral administration.Borax be used for acute tonsillitis, pharyngolaryngitis, laryngopharynx swelling and pain,
Aphtha of the mouth and tongue, stomatitis, gingivitis, otitis media, conjunctival congestion and swelling pain etc..Borneolum Syntheticum delicate fragrance a surname dissipate, and has refreshment of having one's ideas straightened out, and heat clearing away dissipates
Poison, effect of improving acuity of vision and removing nebula.Appropriate Borax and Borneolum Syntheticum is added, it is possible to play the effect of anti-inflammatory and antalgic, can reach in toothpaste
Prevent and treat pulpitis and effect of pain relieving.
The patent application of Publication No. CN1498652A discloses a kind of toothpaste, the health care of this toothpaste and/or the medicine for the treatment of oral disease
Compositions, including for 50-100 weight portion Gypsum Fibrosum, 50-100 weight portion halite, 50-30 weight portion Borneolum Syntheticum, 50-30
Weight portion Flos Caryophylli and 50-30 weight portion Borax.This toothpaste can the generation of effective pre-preventing tooth diseases and the effectively various oral diseases for the treatment of.
But, the effect comparing its anti-inflammatory analgesic with the present invention is poor.
Summary of the invention
Technical problem solved by the invention is to provide the Chinese medicinal toothpaste of a kind of anti-inflammatory analgesic, this toothpaste alleviate gingivitis and pain
Effect bitterly is notable.
The technical scheme that the present invention solves the problems referred to above is as described below:
The Chinese medicinal toothpaste of a kind of anti-inflammatory analgesic, it is characterised in that in every 100g Chinese medicinal toothpaste, the content of Borax is 0.3-4g, ice
The content of sheet is 0.06-4g.
Above-mentioned Chinese medicinal toothpaste is prepared by following methods:
(1) take Borneolum Syntheticum ethanol to dissolve, add tween 80, obtain Borneolum Syntheticum, ethanol and the mixture of tween 80 three, its
Described in Borneolum Syntheticum, the quality proportioning of ethanol and tween 80 three be Borneolum Syntheticum: ethanol: tween 80=1:0.2:0.2；Take Borax
Add the mixing of described mixture after heating for dissolving, prepare mixed liquor 1 standby；
(2) abrasivus, binding agent, sweeting agent and preservative water dissolution are mixed even, prepare mixed liquor 2 standby；
(3) mix in surfactant and wetting agent being added container, the mixed liquor 1 being then sequentially added into and mixed liquor 2 and increasing
Pastil, is stirred, kneads and grinds that to make creme be sufficiently mixed uniform, fine and smooth；It is evacuated to-0.096Mpa, gets rid of creme
In bubble；
(4) squeeze into mastic and store pot ageing 120 minutes, obtain described Chinese medicinal toothpaste；
In above-mentioned steps,
Described abrasivus be the one in calcium carbonate, calcium hydrogen phosphate, calcium hydrogen phosphate anhydrous salt, calcium pyrophosphate and silicate hydrate or
More than two, addition is that every 100g Chinese medicinal toothpaste adds 30-50g；
Described wetting agent is one or more in glycerol, propylene glycol, Polyethylene Glycol and sorbitol, and addition is every 100g
Chinese medicinal toothpaste adds 25-40g；
Described surfactant is one or both in sodium lauryl sulfonate and sodium lauryl sulphate, and addition is every 100g
Chinese medicinal toothpaste adds 1-5g；
Described binding agent is in carboxymethyl cellulose, chondrus ocellatus Holmes, sodium alginate, Cornu Cervi pectin, xanthan gum and guar gum
Planting or two or more, addition is that every 100g Chinese medicinal toothpaste adds 0.8-5g；
Described fumet is in menthol, Oleum menthae, Herba Menthae, apple essence, Fructus Mangifera Indicae essence, Fructus Litchi and flavoring banana essence
Planting or two or more, addition is that every 100g Chinese medicinal toothpaste adds 0.3-1.5g；
Described sweeting agent is one or both of saccharin sodium and xylitol, and addition is that every 100g Chinese medicinal toothpaste adds 0.2-1.5g；
Described preservative is one or both in sorbic acid potassium salt and sodium benzoate, and addition is 0.1-0.5g.
The advantage that the Chinese medicinal toothpaste of the present invention has anti-inflammatory analgesic.Modern pharmacology research shows Borax external heat-clearing and toxic substances removing, controls throat
Swell and ache, aphtha of the mouth and tongue, cataract, removing heat from the lung and dissipating phlegm for oral administration.Borax be used for acute tonsillitis, pharyngolaryngitis, laryngopharynx swelling and pain,
Aphtha of the mouth and tongue, stomatitis, gingivitis, otitis media, conjunctival congestion and swelling pain etc..Borneolum Syntheticum delicate fragrance a surname dissipate, and has refreshment of having one's ideas straightened out, and heat clearing away dissipates
Poison, effect of improving acuity of vision and removing nebula.Appropriate Borax and Borneolum Syntheticum is added, it is possible to play the effect of anti-inflammatory and antalgic, can reach in toothpaste
Prevent and treat pulpitis and effect of red swelling of gingiva.In the present invention, analgesia, antiinflammatory are played a major role by Borax, and Borneolum Syntheticum plays auxiliary
Effect, its analgesia of the two compatibility, antiinflammatory show obvious synergistic function, it is possible to alleviate gingivitis and pain
Effect, shows as each drug action and is substantially better than single Borax or Borneolum Syntheticum.
In order to be more fully understood that the present invention, with the zoopery of Chinese medicinal toothpaste of the present invention, its effect is described below.
The effect experimental of anti-inflammatory analgesic
Test medicine:
Experimental group 1: the toothpaste of following embodiment one.
Experimental group 2: the toothpaste of following embodiment three.
Experimental group 3: the toothpaste of following embodiment five.
Matched group 1: only take 3g by 100g toothpaste and take Borax (consumption of Borneolum Syntheticum is 0), uses in following embodiment 3 each
Proportioning and the method for adjuvant prepare toothpaste.
Matched group 2: only take 3g by 100g toothpaste and take Borneolum Syntheticum (consumption of Borax is 0), uses in following embodiment 3 each
Proportioning and the method for adjuvant prepare toothpaste.
Matched group 3: use the raw material described in description and the consumption of the patent application of Publication No. CN1498652A, say by it
The toothpaste that method described in bright book is prepared.
Western medicine group: compound dexamethason acetate emulsifiable paste.
Dosage:
The dosage of experimental group 1-3 and matched group 1-3 is 3g/kg, 1 times/day.Western medicine group: 0.6g/kg, 1 time/
Day.Medication is administered for coating.
1, mouse writhing experiment (analgesic activity)
SPF level KM mice, 18-22g, male and female half and half, random packet: experimental group 1-3 and matched group 1-3, Western medicine group,
Bare substrate group, often group 10.Before causing inflammation, each group mice is after abdominal part depilation (about 3.0cm × 3.0cm), abdominal part painting
Cloth 1mL or 1g (about 2.5cm × 2.5cm) is administered 7d.After last is administered 0.5h, every Mus lumbar injection 0.6% glacial acetic acid is molten
Liquid 0.2ml/20g body weight, observes and records after injection algogen each mice generation writhing response (abdominal part indent, trunk in 20min
With back leg uphold, hips up) number of times, calculate writhing frequency.
The impact on glacial acetic acid induced mice writhing of table 1 Chinese medicinal toothpaste
Note: compare with bare substrate group, * P < 0.05, * * P < 0.01
2, mice thermostimulation test
SPF level KM mice, male and female half and half, body weight 18-22g.Random packet: experimental group 1-3 and matched group 1-3, west
Medicine group, bare substrate group, often group 10.Before administration, mice is put on Spurs pain instrument, each 1.Record mouse tail pain
The whipping time is as the pain threshold of this Mus.Each mice surveys Basic Pain Threshold secondary, every septum secundum 10min, takes average as pain before this raticide
Threshold value.Each group mice is after abdominal part depilation (about 3.0cm × 3.0cm), and abdominal part is coated with 1mL or 1g (about 2.5cm × 2.5cm)
It is administered 7d.After last medicine, measure the pain threshold of mice, measure as 60 seconds are the most reactionless every time, then mice is taken out, in order to avoid
Scalding, its pain threshold, in terms of 60 seconds, records pain threshold after being administered.
Table 2 Chinese medicinal toothpaste causes the impact of mice pain threshold to thermostimulation test
Note: compare with bare substrate group, * P < 0.05, * * P < 0.01
3, mice capillary permeability test
SPF level KM mice, male and female half and half, body weight 18-22g.Random packet: experimental group 1-3 and matched group 1-3, west
Medicine group, bare substrate group, often group 10.Mouse web portion depilation (about 3.0cm × 3.0cm), abdominal part coating 1mL or 1g is (about
2.5cm × 2.5cm) it is administered 7d, 0.5 hour mouse tail vein injection 0.5% (NS joins) her Wen orchid 0.1ml/10g after last medicine
Body weight.Then, lumbar injection 0.6% glacial acetic acid solution 0.2ml/ is only at once.Sacrificed by decapitation animal after 20 minutes, abdominal cut skin
Skin muscle, with 6ml normal saline mark time washing abdominal cavity, suction pipe sucking-off cleaning mixture, merging cleaning mixture addition normal saline to 10ml
Centrifugal 3000 revs/min, 30min, supernatant surveys OD value at 590nm.
Table 3 Chinese medicinal toothpaste is on the experiment impact of mice capillary permeability
Note: compare with bare substrate group, * P < 0.05, * * P < 0.01
Statistical procedures
Total data uses SPSS 19.0 statistics software to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) table
Show.
Above-mentioned experiment shows, Chinese medicinal toothpaste of the present invention can reduce mouse writhing reaction frequency；The Spurs Severe Pain of mice can be increased
Threshold value, can reduce capillary permeability.Show that Chinese medicinal toothpaste of the present invention has the effect of antiinflammatory, pain relieving.
Detailed description of the invention
The total amount that five embodiments prepare Chinese medicinal toothpaste below is 100g.
Embodiment one
1, formula:
Borax 0.3g, Borneolum Syntheticum 0.06g, propylene glycol 25g, calcium carbonate 40g, calcium hydrogen phosphate 10g, sodium lauryl sulphate 2g,
Sodium carboxymethyl cellulose 5g, sodium benzoate 0.5g, saccharin sodium 0.2g, menthol 0.1g and apple essence 1.4g.
2, preparation method:
Described active component Borax, Borneolum Syntheticum are added propylene glycol mixing, prepares mixed liquor standby；By described calcium carbonate, 12
Point other places such as alkyl sodium sulfate, sodium carboxymethyl cellulose, sodium benzoate, saccharin sodium are managed and with water dissolution to the most standby；By carbon
Acid calcium adds in container, adds sodium lauryl sulphate, sodium carboxymethyl cellulose, sodium benzoate, saccharin sodium；Add Herba Marsileae Quadrifoliae again
Fruital essence, menthol, be stirred, grind, carry out evacuation simultaneously, and till vacuum reaches-0.096Mpa, the time is about
50 minutes.Mediate, grind qualified after, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, make simultaneously
Material fully expands and forms homogeneous adherend, improves the elasticity of material, and digestion time is about 120 minutes.During cream processed,
Temperature≤45 DEG C need to be controlled in summer.
Embodiment two
1, formula:
Borax 1g, Borneolum Syntheticum 0.1g, propylene glycol 20g, Polyethylene Glycol 20g, calcium hydrogen phosphate 30g, sodium lauryl sulfonate 5g, sea
Sodium alginate 3g, sorbic acid potassium salt 0.1g, saccharin sodium 0.1g, xylitol 1g and lychee flavor 0.5g.
2, preparation method:
Described active component Borax, Borneolum Syntheticum are added propylene glycol, Polyethylene Glycol mixing, prepares mixed liquor standby；By described phosphorus
Point other places such as acid hydrogen calcium, sodium lauryl sulfonate, sodium alginate, sorbic acid potassium salt, saccharin sodium are managed and with water dissolution to the most standby；
Calcium hydrogen phosphate is added in container, add sodium lauryl sulfonate, sodium alginate, sorbic acid potassium salt, saccharin sodium；Add litchi again
Branch essence, is stirred, grinds, carry out evacuation simultaneously, and till vacuum reaches-0.096Mpa, the time is about 50 minutes.
Mediate, grind qualified after, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, make material abundant simultaneously
Expanding and form homogeneous adherend, improve the elasticity of material, digestion time is about 120 minutes.During cream processed, in summer
Temperature≤45 DEG C need to be controlled.
Embodiment three
1, formula:
Borax 2g, Borneolum Syntheticum 1g, glycerol 20g, propylene glycol 10g, calcium carbonate 20g, calcium hydrogen phosphate anhydrous salt 10g, lauryl alcohol sulphur
Acid sodium 2g, Cornu Cervi pectin 0.5g, guar gum 0.5g, sorbic acid potassium salt 0.5g, xylitol 1.5g, Oleum menthae 0.1g and awns
Fruital essence 0.2g.
2, preparation method:
Described active component Borax, Borneolum Syntheticum are added glycerol, propylene glycol mixing, prepares mixed liquor standby；By described calcium carbonate,
Point other places such as sodium lauryl sulfonate, Cornu Cervi pectin, guar gum, sorbic acid potassium salt are managed and with water dissolution to the most standby；By carbonic acid
Calcium adds in container, adds sodium lauryl sulfonate, Cornu Cervi pectin, guar gum, sorbic acid potassium salt；Add xylitol, thin again
Lotus oil, Fructus Mangifera Indicae essence, be stirred, grind, carry out evacuation simultaneously, and till vacuum reaches-0.096Mpa, the time is about
50 minutes.Mediate, grind qualified after, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, make simultaneously
Material fully expands and forms homogeneous adherend, improves the elasticity of material, and digestion time is about 120 minutes.During cream processed,
Temperature≤45 DEG C need to be controlled in summer.
Embodiment four
1, formula:
Borax 3g, Borneolum Syntheticum 2g, glycerol 10g, propylene glycol 10g, Polyethylene Glycol 10g, calcium pyrophosphate 20g, silicate hydrate 20g,
Sodium lauryl sulfonate 1g, chondrus ocellatus Holmes 0.3g, xanthan gum 0.5g, sorbic acid potassium salt 0.3g, xylitol 1g, flavoring banana essence 1g.
2, preparation method:
Described active component Borax, Borneolum Syntheticum are added glycerol, propylene glycol, Polyethylene Glycol mixing, prepares mixed liquor standby；By institute
The calcium pyrophosphate stated, silicate hydrate, sodium lauryl sulfonate, sodium lauryl sulphate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt
Decile other places are managed and with water dissolution to the most standby；Calcium pyrophosphate is added in container, add silicate hydrate, lauryl sulfonate
Sodium, sodium lauryl sulphate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt；Add xylitol, flavoring banana essence again, be stirred,
Grinding, carry out evacuation simultaneously, till vacuum reaches-0.096Mpa, the time is about 50 minutes.Mediate, grind qualified after,
Squeeze into mastic storage pot again to be aged, make material naturally cool to room temperature, make material fully expand simultaneously and form homogeneous bonding
Body, improves the elasticity of material, and digestion time is about 120 minutes.During cream processed, temperature≤45 DEG C need to be controlled in summer.
Embodiment five
1, formula:
Borax 4g, Borneolum Syntheticum 4g, glycerol 10g, sorbitol 20g, calcium pyrophosphate 30g, silicate hydrate 10g, sodium lauryl sulfonate
1g, sodium lauryl sulphate 1g, chondrus ocellatus Holmes 0.5g, xanthan gum 0.5g, sorbic acid potassium salt 0.2g, xylitol 0.2g, banana incense
Essence 1g.
2, preparation method:
Described active component Borax, Borneolum Syntheticum are added glycerol, Polyethylene Glycol mixing, prepares mixed liquor standby；By described burnt phosphorus
Point other places such as acid calcium, silicate hydrate, sodium lauryl sulfonate, sodium lauryl sulphate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt
Manage and with water dissolution to the most standby；Calcium pyrophosphate is added in container, add silicate hydrate, sodium lauryl sulfonate, 12
Alkyl sodium sulfate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt；Add xylitol, flavoring banana essence again, be stirred, grind,
Carrying out evacuation, till vacuum reaches-0.096Mpa, the time is about 50 minutes simultaneously.Mediate, grind qualified after, then squeeze into
Mastic stores pot and is aged, and makes material naturally cool to room temperature, makes material fully expand simultaneously and forms homogeneous adherend, carries
The elasticity of high material, digestion time is about 120 minutes.During cream processed, temperature≤45 DEG C need to be controlled in summer.
Claims (2)
1. the Chinese medicinal toothpaste of an anti-inflammatory analgesic, it is characterised in that in every 100g Chinese medicinal toothpaste, the content of Borax is 0.3-4g, and the content of Borneolum Syntheticum is 0.06-4g.
2. the method preparing Chinese medicinal toothpaste described in claim 1, the method comprises the steps of:
(1) taking Borneolum Syntheticum ethanol to dissolve, add tween 80, obtain Borneolum Syntheticum, ethanol and the mixture of tween 80 three, the quality proportioning of wherein said Borneolum Syntheticum, ethanol and tween 80 three is Borneolum Syntheticum: ethanol: tween 80=1:0.2:0.2；Add the mixing of described mixture after taking Borax heating for dissolving, prepare mixed liquor 1 standby；
(2) abrasivus, binding agent, sweeting agent and preservative water dissolution are mixed even, prepare mixed liquor 2 standby；
(3) mix in surfactant and wetting agent are added container, the mixed liquor 1 being then sequentially added into and mixed liquor 2 and fumet, be stirred, knead and grind that to make creme be sufficiently mixed uniform, fine and smooth；It is evacuated to-0.096Mpa, gets rid of the bubble in creme；
(4) squeeze into mastic and store pot ageing 120 minutes, obtain described Chinese medicinal toothpaste；
In above-mentioned steps,
Described abrasivus is the one or more than two in calcium carbonate, calcium hydrogen phosphate, calcium hydrogen phosphate anhydrous salt, calcium pyrophosphate and silicate hydrate, and addition is that every 100g Chinese medicinal toothpaste adds 5-50g；
Described wetting agent is one or more in glycerol, propylene glycol, Polyethylene Glycol and sorbitol, and addition is that every 100g Chinese medicinal toothpaste adds 5-50g；
Described surfactant is one or both in sodium lauryl sulfonate and sodium lauryl sulphate, and addition is that every 100g Chinese medicinal toothpaste adds 1-10g；
Described binding agent is one or more in carboxymethyl cellulose, chondrus ocellatus Holmes, sodium alginate, Cornu Cervi pectin, xanthan gum and guar gum, and addition is that every 100g Chinese medicinal toothpaste adds 0.5-5g；
Described fumet is one or more in menthol, Oleum menthae, Herba Menthae, apple essence, Fructus Mangifera Indicae essence, Fructus Litchi and flavoring banana essence, and addition is that every 100g Chinese medicinal toothpaste adds 0.1-1.5g；
Described sweeting agent is one or both of saccharin sodium and xylitol, and addition is that every 100g Chinese medicinal toothpaste adds 0.1-1.5g；
Described preservative is one or both in sorbic acid potassium salt and sodium benzoate, and addition is that every 100g Chinese medicinal toothpaste adds 0.1-0.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610368248.2A CN105997539A (en) | 2016-05-28 | 2016-05-28 | Anti-inflammatory and analgesic traditional Chinese medicinal toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610368248.2A CN105997539A (en) | 2016-05-28 | 2016-05-28 | Anti-inflammatory and analgesic traditional Chinese medicinal toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105997539A true CN105997539A (en) | 2016-10-12 |
Family
ID=57091210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610368248.2A Pending CN105997539A (en) | 2016-05-28 | 2016-05-28 | Anti-inflammatory and analgesic traditional Chinese medicinal toothpaste |
Country Status (1)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821902A (en) * | 2016-12-23 | 2017-06-13 | 李大兴 | A kind of Chinese medicinal toothpaste |
| CN109350581A (en) * | 2017-12-26 | 2019-02-19 | 李文婷 | A kind of oral cavity nursing agent of anti-inflammatory whitening |
-
2016
- 2016-05-28 CN CN201610368248.2A patent/CN105997539A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821902A (en) * | 2016-12-23 | 2017-06-13 | 李大兴 | A kind of Chinese medicinal toothpaste |
| CN109350581A (en) * | 2017-12-26 | 2019-02-19 | 李文婷 | A kind of oral cavity nursing agent of anti-inflammatory whitening |
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Application publication date: 20161012 |