CN105943409A - Traditional Chinese medicinal toothpaste for alleviating redness-swollenness and bleeding as well as pain of gum - Google Patents
Traditional Chinese medicinal toothpaste for alleviating redness-swollenness and bleeding as well as pain of gum Download PDFInfo
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- CN105943409A CN105943409A CN201610368314.6A CN201610368314A CN105943409A CN 105943409 A CN105943409 A CN 105943409A CN 201610368314 A CN201610368314 A CN 201610368314A CN 105943409 A CN105943409 A CN 105943409A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention relates to traditional Chinese medicinal toothpaste for alleviating the redness-swollenness and the bleeding as well as the pain of a gum. The traditional Chinese medicinal toothpaste for alleviating the redness-swollenness and the bleeding as well as the pain of the gum is characterized in that, in every 100g of the traditional Chinese medicinal toothpaste, the content of paeonol is 0.6g to 5g, and the content of borneol is 0.06g to 3g. The traditional Chinese medicinal toothpaste provided by the invention is obvious in the effects of alleviating the redness-swollenness and the bleeding as well as the pain of the gum.
Description
Invention field
The present invention relates to tooth goods, this tooth with goods containing organic compound, have alleviate red swelling of gingiva, hemorrhage, pain excellent
Point.
Technical background
The tooth of the most a lot of people has gingivitis, if gingivitis is treated not in time or malpractice, red swelling of gingiva may persistently be deposited
, and it is possible to it is further developed into as periodontitis.Show as red swelling of gingiva, hemorrhage, the symptom of pain, notice that oral cavity is defended
Raw, form after good tooth-brushing habit can effectively prevent gingivitis, the morbidity of periodontitis or treatment and prevent recurrence.Therefore toothpaste
Cleaning tooth, the effect taken care of one's teeth can not be ignored.According to the curative effect of medicine, toothpaste adds suitable medicine, makes people
During the brushing teeth of every day, it is not only able to clean tooth, the effect in pure and fresh oral cavity, moreover it is possible to play taking care of one's teeth, prevent odontopathy
Occurring, alleviate or alleviate the effect that gingivitis occurs, paeonol has analgesia, antiinflammatory, the antipyretic and work of suppression allergy
With；Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold；GUIXIN, liver, lung meridian；Delicate fragrance a surname dissipate, have refreshment of having one's ideas straightened out, heat clearing away dissipate poison, improving eyesight,
Effect of pain relieving.
The patent application of Publication No. CN201110086550 discloses a kind of toothpaste, this toothpaste contain cleaning oral cavity, go antihalitosis,
Eliminating oral disease active component, wherein removing stain active component is the Radix Scutellariae of 0.05%-0.4% by the constituent content of mass percent
Glycoside, the chlorophyll of 0.01%-0.05% or its copper sodium, the paeonol of 0.014%-0.075%, 0.014%-0.09% Oleum Caryophylli,
The Borneolum Syntheticum of 0.0007%-0.0135% and the thymol composition of 0.007%-0.045%.This toothpaste have make oral disease such as gingivitis,
The effect that the symptoms such as gingival hemorrhage, halitosis and tooth body allergy are effectively alleviated, but, the effect alleviating gingival hemorrhage pain relieving is owed
Good.
Summary of the invention
Technical problem solved by the invention is to provide the Chinese medicinal toothpaste of a kind of anti-inflammatory, repercussive and analgesic, this toothpaste alleviate red swelling of gingiva,
Hemorrhage, pain effect is notable.
The technical scheme that the present invention solves the problems referred to above is as described below:
A kind of Chinese medicinal toothpaste alleviating gingival hemorrhage pain relieving, it is characterised in that in every 100g Chinese medicinal toothpaste, the content of paeonol is
0.6-5g, the content of Borneolum Syntheticum is 0.06-3g.
Above-mentioned Chinese medicinal toothpaste is prepared by following methods:
(1) take paeonol ethanol to dissolve, add tween 80 and obtain mixture A, wherein said paeonol, ethanol and tell
The quality proportioning of temperature three is paeonol: ethanol: tween 80=1:0.2:0.2；Separately take Borneolum Syntheticum ethanol to dissolve, add and tell
Temperature-80 waits until mixture B, and the quality proportioning of wherein said Borneolum Syntheticum, ethanol and tween 80 three is Borneolum Syntheticum: ethanol: tween 80
=1:0.2:0.2；Mixture A and mixture B is mixed, prepares mixed liquor 1 standby；
(2) abrasivus, binding agent, sweeting agent and preservative water dissolution are mixed even, prepare mixed liquor 2 standby；
(3) mix in surfactant and wetting agent being added container, the mixed liquor 1 being then sequentially added into and mixed liquor 2 and increasing
Pastil, is stirred, kneads and grinds that to make creme be sufficiently mixed uniform, fine and smooth；It is evacuated to-0.096Mpa, gets rid of creme
In bubble；
(4) squeeze into mastic and store pot ageing 120 minutes, obtain described Chinese medicinal toothpaste；
In above-mentioned steps,
Described abrasivus be the one in calcium carbonate, calcium hydrogen phosphate, calcium hydrogen phosphate anhydrous salt, calcium pyrophosphate and silicate hydrate or
More than two, addition is that every 100g Chinese medicinal toothpaste adds 30-50g；
Described wetting agent is one or more in glycerol, propylene glycol, Polyethylene Glycol and sorbitol, and addition is every 100g
Chinese medicinal toothpaste adds 25-40g；
Described surfactant is one or both in sodium lauryl sulfonate and sodium lauryl sulphate, and addition is every 100g
Chinese medicinal toothpaste adds 1-5g；
Described binding agent is in carboxymethyl cellulose, chondrus ocellatus Holmes, sodium alginate, Cornu Cervi pectin, xanthan gum and guar gum
Planting or two or more, addition is that every 100g Chinese medicinal toothpaste adds 0.8-5g；
Described fumet is in menthol, Oleum menthae, Herba Menthae, apple essence, Fructus Mangifera Indicae essence, Fructus Litchi and flavoring banana essence
Planting or two or more, addition is that every 100g Chinese medicinal toothpaste adds 0.3-1.5g；
Described sweeting agent is one or both of saccharin sodium and xylitol, and addition is that every 100g Chinese medicinal toothpaste adds 0.2-1.5g；
Described preservative is one or both in sorbic acid potassium salt and sodium benzoate, and addition is that every 100g Chinese medicinal toothpaste adds
0.1-0.5g。
The Chinese medicinal toothpaste of the present invention has can alleviate red swelling of gingiva, hemorrhage, the advantage of pain.Modern pharmacology research shows Cortex Moutan
Phenol has analgesia, antiinflammatory, the antipyretic and effect of suppression allergy；Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold；GUIXIN, liver, lung meridian；
Delicate fragrance a surname dissipate, and has refreshment of having one's ideas straightened out, heat clearing away scattered poison, improving eyesight, effect of pain relieving.Pharmacodynamic results of the present invention shows paeonol compatibility
The single medicinal material that is better than evident in efficacy of Borneolum Syntheticum, in the present invention paeonol to analgesia, antiinflammatory, antipyretic play a major role, Borneolum Syntheticum plays auxiliary
Effect, its analgesia of the two compatibility, antiinflammatory show obvious synergistic function, it is possible to alleviate red swelling of gingiva, hemorrhage, pain
Effect, show as each drug action and be substantially better than single paeonol or Borneolum Syntheticum.
In order to be more fully understood that the present invention, with the zoopery of Chinese medicinal toothpaste of the present invention, its effect is described below.
Alleviate red swelling of gingiva, hemorrhage, the effect experimental of pain
Test medicine:
Experimental group 1: the toothpaste of following embodiment one.
Experimental group 2: the toothpaste of following embodiment three.
Experimental group 3: the toothpaste of following embodiment five.
Matched group 1: only take 2g by 100g toothpaste and take paeonol (consumption of Borneolum Syntheticum is 0), use in following embodiment 3
Proportioning and the method for each adjuvant prepare toothpaste.
Matched group 2: only take 2g by 100g toothpaste and take Borneolum Syntheticum (consumption of paeonol is 0), use in following embodiment 3
Proportioning and the method for each adjuvant prepare toothpaste.
Matched group 3: use the raw material described in description [0021st] section of Publication No. CN201110086550 patent application
And consumption, the toothpaste that the method as described in its description [0022nd] section is prepared.
Western medicine group: compound dexamethason acetate emulsifiable paste.
Dosage:
The dosage of experimental group 1-3 and matched group 1-3 is 2g/kg, 1 times/day.Western medicine group: 0.6g/kg, 1 time/
Day.Medication is administered for coating.
1, mice ear experiment
SPF level KM mice, 18-22g, male, it is randomly divided into experimental group, matched group, Western medicine group and bare substrate group, totally 8
Group, often group 10.Cause scorching front mouse web portion depilation (about 3.0cm × 3.0cm), abdominal part coating 1mL or 1g (about 2.5cm
× 2.5cm) it is administered 7d, bare substrate group is coated with bare substrate group toothpaste.Coating is administered 7d.After last is administered 0.5h, every Mus is left
Ear two topcoating 100% dimethylbenzene 0.02ml causes inflammation, and auris dextra compares.Put to death animal after causing scorching 2h, cut two ears along auricle baseline,
Laying ears same position disk with diameter 9mm card punch, electronic analytical balance is weighed, calculating swelling: swelling=left ear
Tablet weight-auris dextra tablet weight.The scorching auris dextra weight-left ear weight of swelling=cause；Inhibitory rate of intumesce %=(bare substrate group swelling-administration
Group swelling)/bare substrate group swelling × 100%
The impact of ear swelling degree caused by table 1 Chinese medicinal toothpaste xylol
Note: compare with bare substrate group, * P < 0.05, * * P < 0.01
2, mouse writhing experiment (analgesic activity)
SPF level KM mice, 18-22g, male and female half and half, random packet: experimental group 1-3 and matched group 1-3, Western medicine group,
Bare substrate group, often group 10.Before causing inflammation, each group mice is after abdominal part depilation (about 3.0cm × 3.0cm), abdominal part painting
Cloth 1mL or 1g (about 2.5cm × 2.5cm) is administered 7d.After last is administered 0.5h, every Mus lumbar injection 0.6% glacial acetic acid is molten
Liquid 0.2ml/20g body weight, observes and records after injection algogen each mice generation writhing response (abdominal part indent, trunk in 20min
With back leg uphold, hips up) number of times, calculate writhing frequency.
The impact on glacial acetic acid induced mice writhing of table 2 Chinese medicinal toothpaste
Note: compare with bare substrate group, * P < 0.05, * * P < 0.01
3, mice thermostimulation test
SPF level KM mice, male and female half and half, body weight 18-22g.Random packet: experimental group 1-3 and matched group 1-3, west
Medicine group, bare substrate group, often group 10.Before administration, mice is put on Spurs pain instrument, each 1.Record mouse tail pain
The whipping time is as the pain threshold of this Mus.Each mice surveys Basic Pain Threshold secondary, every septum secundum 10min, takes average as pain before this raticide
Threshold value.Each group mice is after abdominal part depilation (about 3.0cm × 3.0cm), and abdominal part is coated with 1mL or 1g (about 2.5cm × 2.5cm)
It is administered 7d.After last medicine, measure the pain threshold of mice, measure as 60 seconds are the most reactionless every time, then mice is taken out, in order to avoid
Scalding, its pain threshold, in terms of 60 seconds, records pain threshold after being administered.
Table 3 Chinese medicinal toothpaste causes the impact of mice pain threshold to thermostimulation test
Note: compare with bare substrate group, * P < 0.05, * * P < 0.01
Statistical procedures
Total data uses SPSS 19.0 statistics software to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) table
Show.
Above-mentioned experiment shows, Chinese medicinal toothpaste of the present invention has the degree of suppression mice ear；Mouse writhing reaction can be reduced occur
Number of times；The thermostimulation pain threshold of mice can be increased.Show that Chinese medicinal toothpaste of the present invention has the effect of antiinflammatory, detumescence, pain relieving.
Detailed description of the invention
The total amount that five embodiments prepare Chinese medicinal toothpaste below is 100g.
Embodiment one
1, formula:
Paeonol 0.6g, Borneolum Syntheticum 0.06g, propylene glycol 25g, calcium carbonate 40g, calcium hydrogen phosphate 10g, sodium lauryl sulphate 2g,
Sodium carboxymethyl cellulose 5g, sodium benzoate 0.5g, saccharin sodium 0.2g, menthol 0.1g and apple essence 1.4g.
2, preparation method:
Described active component paeonol, Borneolum Syntheticum are added propylene glycol mixing, prepares mixed liquor standby；By described calcium carbonate, ten
Point other places such as sodium dialkyl sulfate, sodium carboxymethyl cellulose, sodium benzoate, saccharin sodium are managed and with water dissolution to the most standby；Will
Calcium carbonate adds in container, adds sodium lauryl sulphate, sodium carboxymethyl cellulose, sodium benzoate, saccharin sodium；Add again
Apple essence, menthol, be stirred, grind, and carries out evacuation simultaneously, and till vacuum reaches-0.096Mpa, the time is about
It it is 50 minutes.Mediate, grind qualified after, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, simultaneously
Making material fully expand and form homogeneous adherend, improve the elasticity of material, digestion time is about 120 minutes.In cream process processed
In, temperature≤45 DEG C need to be controlled in summer.
Embodiment two
1, formula: paeonol 2g, Borneolum Syntheticum 1g, propylene glycol 20g, Polyethylene Glycol 20g, calcium hydrogen phosphate 30g, lauryl sulfonate
Sodium 5g, sodium alginate 3g, sorbic acid potassium salt 0.1g, saccharin sodium 0.1g, xylitol 1g and lychee flavor 0.5g.
2, preparation method:
Described active component paeonol, Borneolum Syntheticum are added propylene glycol, Polyethylene Glycol mixing, prepares mixed liquor standby；By described
Point other places such as calcium hydrogen phosphate, sodium lauryl sulfonate, sodium alginate, sorbic acid potassium salt, saccharin sodium are managed and with water dissolution to the most standby
With；Calcium hydrogen phosphate is added in container, add sodium lauryl sulfonate, sodium alginate, sorbic acid potassium salt, saccharin sodium；Add again
Adding lychee flavor, be stirred, grind, carry out evacuation simultaneously, till vacuum reaches-0.096Mpa, the time is about 50 points
Clock.Mediate, grind qualified after, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, make material simultaneously
Fully expanding and form homogeneous adherend, improve the elasticity of material, digestion time is about 120 minutes.During cream processed,
Summer need to control temperature≤45 DEG C.
Embodiment three
1, formula:
Paeonol 3g, Borneolum Syntheticum 1.5g, glycerol 20g, propylene glycol 10g, calcium carbonate 20g, calcium hydrogen phosphate anhydrous salt 10g, Laurel
Alcohol sodium sulfonate 2g, Cornu Cervi pectin 0.5g, guar gum 0.5g, sorbic acid potassium salt 0.5g, xylitol 1.5g, Oleum menthae 0.1g
With Fructus Mangifera Indicae essence 0.2g.
2, preparation method:
Described active component paeonol, Borneolum Syntheticum are added glycerol, propylene glycol mixing, prepares mixed liquor standby；By described carbonic acid
Point other places such as calcium, sodium lauryl sulfonate, Cornu Cervi pectin, guar gum, sorbic acid potassium salt are managed and with water dissolution to the most standby；Will
Calcium carbonate adds in container, adds sodium lauryl sulfonate, Cornu Cervi pectin, guar gum, sorbic acid potassium salt；Add again xylitol,
Oleum menthae, Fructus Mangifera Indicae essence, be stirred, grind, and carries out evacuation simultaneously, and till vacuum reaches-0.096Mpa, the time is about
It it is 50 minutes.Mediate, grind qualified after, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, simultaneously
Making material fully expand and form homogeneous adherend, improve the elasticity of material, digestion time is about 120 minutes.In cream process processed
In, temperature≤45 DEG C need to be controlled in summer.
Embodiment four
1, formula:
Paeonol 4g, Borneolum Syntheticum 2g, glycerol 10g, propylene glycol 10g, Polyethylene Glycol 10g, calcium pyrophosphate 20g, silicate hydrate
20g, sodium lauryl sulfonate 1g, chondrus ocellatus Holmes 0.3g, xanthan gum 0.5g, sorbic acid potassium salt 0.3g, xylitol 1g, banana incense
Essence 1g.
2, preparation method:
Described active component paeonol, Borneolum Syntheticum are added glycerol, propylene glycol, Polyethylene Glycol mixing, prepares mixed liquor standby；Will
Described calcium pyrophosphate, silicate hydrate, sodium lauryl sulfonate, sodium lauryl sulphate, chondrus ocellatus Holmes, xanthan gum, potassium sorbate
Salt etc. point other places are managed and with water dissolution to the most standby；Calcium pyrophosphate is added in container, add silicate hydrate, lauryl alcohol sulphur
Acid sodium, sodium lauryl sulphate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt；Add xylitol, flavoring banana essence again, stir
Mixing, grind, carry out evacuation simultaneously, till vacuum reaches-0.096Mpa, the time is about 50 minutes.Mediate, grind qualified
After, then squeeze into mastic store pot be aged, make material naturally cool to room temperature, make simultaneously material fully expand formation homogeneous
Adherend, improves the elasticity of material, and digestion time is about 120 minutes.During cream processed, temperature≤45 DEG C need to be controlled in summer.
Embodiment five
1, formula:
Paeonol 5g, Borneolum Syntheticum 3g, glycerol 10g, sorbitol 20g, calcium pyrophosphate 30g, silicate hydrate 10g, lauryl sulfonate
Sodium 1g, sodium lauryl sulphate 1g, chondrus ocellatus Holmes 0.5g, xanthan gum 0.5g, sorbic acid potassium salt 0.2g, xylitol 0.2g, Fructus Musae
Essence 1g.
2, preparation method:
Described active component paeonol, Borneolum Syntheticum are added glycerol, Polyethylene Glycol mixing, prepares mixed liquor standby；By described Jiao
Calcium phosphate, silicate hydrate, sodium lauryl sulfonate, sodium lauryl sulphate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt decile are other
Process and with water dissolution to the most standby；Calcium pyrophosphate is added in container, add silicate hydrate, sodium lauryl sulfonate, ten
Sodium dialkyl sulfate, chondrus ocellatus Holmes, xanthan gum, sorbic acid potassium salt；Add xylitol, flavoring banana essence again, be stirred, grind,
Carrying out evacuation, till vacuum reaches-0.096Mpa, the time is about 50 minutes simultaneously.Mediate, grind qualified after, then squeeze into
Mastic stores pot and is aged, and makes material naturally cool to room temperature, makes material fully expand simultaneously and forms homogeneous adherend, carries
The elasticity of high material, digestion time is about 120 minutes.During cream processed, control temperature≤45 DEG C in summer.
Claims (2)
1. one kind alleviates red swelling of gingiva, hemorrhage, the Chinese medicinal toothpaste of pain, it is characterised in that in every 100g Chinese medicinal toothpaste, red
The content of skin phenol is 0.6-5g, and the content of Borneolum Syntheticum is 0.06-3g.
2. the method preparing Chinese medicinal toothpaste described in claim 1, the method comprises the steps of:
(1) take paeonol ethanol to dissolve, add tween 80 and obtain mixture A, wherein said paeonol, ethanol and tell
The quality proportioning of temperature three is paeonol: ethanol: tween 80=1:0.2:0.2；Separately take Borneolum Syntheticum ethanol to dissolve, add and tell
Temperature-80 waits until mixture B, and the quality proportioning of wherein said Borneolum Syntheticum, ethanol and tween 80 three is Borneolum Syntheticum: ethanol: tween 80
=1:0.2:0.2；Mixture A and mixture B is mixed, prepares mixed liquor 1 standby；
(2) abrasivus, binding agent, sweeting agent and preservative water dissolution are mixed even, prepare mixed liquor 2 standby；
(3) mix in surfactant and wetting agent being added container, the mixed liquor 1 being then sequentially added into and mixed liquor 2 and increasing
Pastil, is stirred, kneads and grinds that to make creme be sufficiently mixed uniform, fine and smooth；It is evacuated to-0.096Mpa, gets rid of creme
In bubble；
(4) squeeze into mastic and store pot ageing 120 minutes, obtain described Chinese medicinal toothpaste；
In above-mentioned steps,
Described abrasivus be the one in calcium carbonate, calcium hydrogen phosphate, calcium hydrogen phosphate anhydrous salt, calcium pyrophosphate and silicate hydrate or
More than two, addition is that every 100g Chinese medicinal toothpaste adds 5-50g；
Described wetting agent is one or more in glycerol, propylene glycol, Polyethylene Glycol and sorbitol, and addition is every 100g
Chinese medicinal toothpaste adds 5-50g；
Described surfactant is one or both in sodium lauryl sulfonate and sodium lauryl sulphate, and addition is every 100g
Chinese medicinal toothpaste adds 1-10g；
Described binding agent is in carboxymethyl cellulose, chondrus ocellatus Holmes, sodium alginate, Cornu Cervi pectin, xanthan gum and guar gum
Planting or two or more, addition is that every 100g Chinese medicinal toothpaste adds 0.5-5g；
Described fumet is in menthol, Oleum menthae, Herba Menthae or apple essence, Fructus Mangifera Indicae essence, Fructus Litchi and flavoring banana essence
Planting or two or more, addition is that every 100g Chinese medicinal toothpaste adds 0.1-1.5g；
Described sweeting agent is one or both of saccharin sodium and xylitol, and addition is that every 100g Chinese medicinal toothpaste adds 0.1-1.5g；
Described preservative is one or both in sorbic acid potassium salt and sodium benzoate, and addition is that every 100g Chinese medicinal toothpaste adds
0.1-0.5g。
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| CN201610368314.6A CN105943409B (en) | 2016-05-28 | 2016-05-28 | A kind of Chinese medicinal toothpaste mitigating gum redness bleeding pain |
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| CN201610368314.6A CN105943409B (en) | 2016-05-28 | 2016-05-28 | A kind of Chinese medicinal toothpaste mitigating gum redness bleeding pain |
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| CN105943409B CN105943409B (en) | 2019-04-02 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106821902A (en) * | 2016-12-23 | 2017-06-13 | 李大兴 | A kind of Chinese medicinal toothpaste |
| CN108125813A (en) * | 2018-01-17 | 2018-06-08 | 卢鹤文 | Tooth liquid is gargled in a kind of bactericidal antiphlogistic detumescence |
| CN108743613A (en) * | 2018-07-03 | 2018-11-06 | 张嵩 | A kind of dental alleviates the mouth sprays and its preparation method of bleeding gums |
| CN111686036A (en) * | 2020-08-03 | 2020-09-22 | 广州市美如初化妆品有限公司 | Toothpaste for relieving gingival red swelling, bleeding and pain and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106821902A (en) * | 2016-12-23 | 2017-06-13 | 李大兴 | A kind of Chinese medicinal toothpaste |
| CN108125813A (en) * | 2018-01-17 | 2018-06-08 | 卢鹤文 | Tooth liquid is gargled in a kind of bactericidal antiphlogistic detumescence |
| CN108743613A (en) * | 2018-07-03 | 2018-11-06 | 张嵩 | A kind of dental alleviates the mouth sprays and its preparation method of bleeding gums |
| CN111686036A (en) * | 2020-08-03 | 2020-09-22 | 广州市美如初化妆品有限公司 | Toothpaste for relieving gingival red swelling, bleeding and pain and preparation process thereof |
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| CN105943409B (en) | 2019-04-02 |
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