CN1718226A - Medicine composition for treating leuconychia, and its prepn. method - Google Patents
Medicine composition for treating leuconychia, and its prepn. method Download PDFInfo
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- CN1718226A CN1718226A CN 200510025686 CN200510025686A CN1718226A CN 1718226 A CN1718226 A CN 1718226A CN 200510025686 CN200510025686 CN 200510025686 CN 200510025686 A CN200510025686 A CN 200510025686A CN 1718226 A CN1718226 A CN 1718226A
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Abstract
A Chinese medicine in the form of oil for preventing and treating onychomycosis, tinea manuum, tinea pedis, eczema, psoriasis, etc is prepared from cloves oil (20-60 wt.%) and fennel oil (40-80 wt.%).
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of tinea unguium and tinea manus and pedis, be specifically related to a kind of pharmaceutical composition that comprises Oleum Caryophylli and Oleum Anisi Stellati.
Background technology
Tinea unguium is by fungus-caused a kind of common frdquently encountered disease, and preventing and kill fungal infection also is an important topic of current research.According to incompletely statistics, very high in China because of the tinea manus and pedis infection rate that fungal infection causes.Southern area can reach 50-60%, and the north also reaches 40-50%.Some special professional infection rates can reach 80-100%.And the untimely prevention of fungus that shallow table infects or kill can cause the deep skin infection.Thereby infecting tinea unguium and fungus will more be difficult to kill, and bring inconvenience in work, life, the social activity to the patient.
The medicine of existing treatment tinea unguium is poisonous mostly, use also suitable trouble, for example to take out original tinea unguium, will scrape thin original tinea unguium or medicine-feeding back several days can not water, and this medicine generally has pair skin to have stimulation, tinea unguium to cure back shortcoming such as bounce-back easily.
Chinese patent application CN1454656 discloses a kind of medicine for the treatment of tinea unguium and tinea manus and pedis, and it comprises raw materials such as natural plants Flos Caryophylli, Bulbus Allii and makes by extraction.But, prepare the method more complicated of this pharmaceutical composition, need the long time.
Existing market has a kind of pharmaceutical composition, and it is to make by extracting raw materials such as natural plants Flos Caryophylli and Fructus Foeniculi.But the curative effect of this pharmaceutical composition is general, and its outward appearance is a black non transparent.
In sum, this area still lacks the medicine of effectively treatment and prevention tinea unguium and tinea manus and pedis.Therefore, still need a kind of medicine that can effectively treat and prevent tinea unguium and tinea manus and pedis at present.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of tinea unguium and tinea manus and pedis.
One aspect of the present invention provides a kind of pharmaceutical composition, and it comprises the Oleum Caryophylli of 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion.
In a preferred embodiment of the present invention, the consumption of described Oleum Caryophylli is the 30-50 weight portion, and the consumption of described Oleum Anisi Stellati is the 50-70 weight portion.
In another preferred embodiment of the present invention, the consumption of described Oleum Caryophylli is 40 weight portions, and the consumption of described Oleum Anisi Stellati is 60 weight portions.
In another preferred embodiment of the present invention, described pharmaceutical composition also can comprise in safflower oil, Oleum menthae, Oleum Folium Artemisiae Argyi and the Oleum Camphora of 0.5-30 weight portion one or more.
In another preferred embodiment of the present invention, the consumption 0.5-15 weight portion of described safflower oil, the consumption 0.5-15 weight portion of described Oleum menthae, the consumption of described Oleum Folium Artemisiae Argyi are that the consumption of 0.5-15 weight portion or described Oleum Camphora is the 0.5-15 weight portion.
The present invention also provides a kind of pharmaceutical composition, and it is made up of the Oleum Caryophylli of 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion.
The present invention also provides a kind of pharmaceutical composition, and one or more are formed in its safflower oil, Oleum menthae, Oleum Folium Artemisiae Argyi and Oleum Camphora by the Oleum Anisi Stellati of the Oleum Caryophylli of 20-60 weight portion, 40-80 weight portion and 0.5-30 weight portion.
In a preferred embodiment of the present invention, described pharmaceutical composition is a liquid preparation.
The present invention also provides a kind of method of making aforementioned pharmaceutical compositions, and it comprises the Oleum Caryophylli of mixing 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion, the pharmaceutical composition that obtains.
The present invention also provide described pharmaceutical composition in preparation treatment tinea unguium, tinea manus and pedis, fungal infection of hand and foot, wet disease, redness, scratch where it itches, the purposes in the medicine of psoriasis and desquamation.
Tinea unguium and tinea manus and pedis can be treated and prevent to pharmaceutical composition of the present invention effectively, and instant effect.Bounce-back hardly after tinea unguium is cured.Simultaneously, pharmaceutical composition of the present invention does not have toxicity to fingernail and skin, and fingernail is had compaction, and embrocating has a kind of feel cool on skin.Pharmaceutical composition of the present invention can not only effectively be treated tinea unguium, tinea manus and pedis, also can be used for fungal infection of hand and foot and wet disease, redness, scratches where it itches, general treating for skin disease such as desquamation, psoriasis, and is evident in efficacy.In addition, medicine of the present invention is a water white transparency shape liquid, and special fragrance is arranged, and accepts for patient easily.
The specific embodiment
The inventor discovers through the several years, is used in combination Oleum Anisi Stellati and Oleum Caryophylli and can treats and prevent tinea unguium and tinea manus and pedis effectively.According to above-mentioned discovery, the spy has finished the present invention.
Active component
The invention provides a kind of pharmaceutical composition, it comprises the Oleum Caryophylli of 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion.
The used Oleum Caryophylli of the present invention can be Oleum Caryophylli and eugenol.The used Oleum Caryophylli of the present invention can be the commercially available prod.
In pharmaceutical composition of the present invention, the consumption of described Oleum Caryophylli is the 20-60 weight portion.In a preferred embodiment of the present invention, the consumption of described Oleum Caryophylli is the 30-50 weight portion.In another preferred embodiment of the present invention, the consumption of described Oleum Caryophylli is 40 weight portions.
Usually, in pharmaceutical composition of the present invention, the content of described Oleum Caryophylli is 15-65 weight %, is preferably 30-50 weight %, in the gross weight of described pharmaceutical composition.
In the present invention, described Oleum Anisi Stellati can be the mixture of any one or two kinds in Oleum Anisi Stellati and the fennel oil.In a preferred embodiment of the present invention, described Oleum Anisi Stellati is an Oleum Anisi Stellati.The used Oleum Anisi Stellati of the present invention can be the commercially available prod.
In pharmaceutical composition of the present invention, the consumption of described Oleum Anisi Stellati is the 40-80 weight portion.In a preferred embodiment of the present invention.The consumption of described Oleum Anisi Stellati is the 50-70 weight portion.In another preferred embodiment of the present invention, the consumption of described Oleum Anisi Stellati is 60 weight portions.
Usually, in pharmaceutical composition of the present invention, the content of described Oleum Anisi Stellati is 35-85 weight %, is preferably 50-70 weight portion %, in the gross weight of described pharmaceutical composition.
In the present invention, the weight ratio for described Oleum Caryophylli and Oleum Anisi Stellati does not specifically limit.In a preferred embodiment of the present invention, the weight ratio of described Oleum Caryophylli and Oleum Anisi Stellati is 1: 1-1: 2.In another preferred embodiment of the present invention, the weight ratio of described Oleum Caryophylli and Oleum Anisi Stellati is 1: 1.5.
Auxiliary element
Except above-mentioned active substance, pharmaceutical composition of the present invention also can randomly comprise other helper components, for example safflower oil, Oleum menthae, Oleum Folium Artemisiae Argyi, Camphora wet goods.
In the present invention, described safflower oil can be a carthamin.In the present invention, the consumption of described safflower oil is the 0.5-15 weight portion, is preferably the 5-12 weight portion, more preferably 10 weight portions.
In the present invention, described Oleum menthae can be one or more in Mentholum and the Oleum menthae.In the present invention, the consumption of described Oleum menthae is the 0.5-15 weight portion, is preferably the 5-12 weight portion, more preferably 10 weight portions.
In the present invention, described Oleum Folium Artemisiae Argyi can be commercially available Oleum Folium Artemisiae Argyi.In the present invention, the consumption 0.5-15 weight portion of described Oleum Folium Artemisiae Argyi is preferably the 5-12 weight portion, more preferably 10 weight portions.
In the present invention, described Oleum Camphora can be an artificial camphor.In the present invention, the consumption of described Oleum Camphora is the 0.5-15 weight portion, is preferably the 5-12 weight portion, more preferably 10 weight portions.
Because Oleum Caryophylli and Oleum Anisi Stellati are in suitable the stablizing of occurring in nature, color is more transparent, and unique fragrance is arranged, so pharmaceutical composition of the present invention generally need not to add antioxidant, flavouring agent and pigment etc.
But, having better stability, abnormal smells from the patient and outward appearance etc. in order to make described pharmaceutical composition, pharmaceutical composition of the present invention also can add various pharmaceutically acceptable additives, for example antioxidant, flavouring agent, odor mask, pigment or diluent etc.These additives all are to know in this area.
In the present invention, total consumption of described additive is the 0.01-10 weight portion, is preferably the 0.1-5 weight portion, more preferably 1 weight portion.
Solvent
In the present invention, described active component and helper component can also be dissolved in the solvent.Described solvent is selected from pharmaceutically acceptable conventional solvent, for example ethanol etc.
In the present invention, do not limit for the consumption of solvent is concrete, as long as can dissolve described active component and helper component.In a preferred embodiment of the present invention, the consumption of described solvent is the 20-100 weight portion.In another preferred embodiment of the present invention, the consumption of described solvent is the 40-60 weight portion.In another preferred embodiment of the present invention, the consumption of described solvent is 50 weight portions.
Pharmaceutical composition of the present invention can use conventional method preparation, for example just can pharmaceutical composition of the present invention by simple each component of mixing.
The using method of pharmaceutical composition of the present invention is very simple, can be applied directly to the affected part or is applied in uniformly on the adjacent skin of fingernail, nail groove and fingernail, once a day.Apply back 10-25 minute, wipe undried liquid and partly get final product.
Pharmaceutical composition of the present invention all has better curative effect for tinea unguium and tinea manus and pedis.General tinea unguium patient uses pharmaceutical composition of the present invention just can grow new, healthy fingernail in several days to tens days.Take effect immediately after the various tinea manus and pedis patient medication, use the present composition once just can obviously not itch the back, be difficult for recurrence after the rehabilitation.Simultaneously, pharmaceutical composition of the present invention does not have toxicity to fingernail and skin, and fingernail is had compaction, thereby can effectively prevent tinea unguium.Described pharmaceutical composition is embrocated a kind of feel cool on skin.Pharmaceutical composition of the present invention can not only effectively be treated tinea unguium, tinea manus and pedis, also can be used for fungal infection of hand and foot and wet disease, redness, scratches where it itches, general treating for skin disease such as desquamation, psoriasis, and is evident in efficacy.In addition, medicine of the present invention is a water white transparency shape liquid, and special fragrance is arranged, and accepts for patient easily.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition of advising according to manufacturer.
Embodiment
Embodiment 1
Get 20 gram Oleum Caryophyllis (Shanghai Shenbao Flavor ﹠ Fragrance Co., Ltd. (90%)), the 30 smart anise-oils of gram (Shanghai Shenbao Flavor ﹠ Fragrance Co., Ltd. (15 degree) are put into 100 ml beakers, stir fast and obtain uniform mixture, thereby make pharmaceutical composition of the present invention, it is a colourless transparent liquid.
Embodiment 2
Get 10 gram Oleum Caryophyllis (Shanghai Shenbao Flavor ﹠ Fragrance Co., Ltd. (90%)), the smart anise-oil of 40 grams (Shanghai Shenbao Flavor ﹠ Fragrance Co., Ltd. (15 degree)) and 5 gram Oleum Folium Artemisiae Argyis and put into 100 ml beakers, stir fast and obtain uniform mixture, thereby make pharmaceutical composition of the present invention.
Embodiment 3
Get 30 gram Oleum Caryophyllis (Shanghai Shenbao Flavor ﹠ Fragrance Co., Ltd. (90%)), the smart anise-oil of 30 grams (Shanghai Shenbao Flavor ﹠ Fragrance Co., Ltd. (15 degree)), 5 gram Oleum Folium Artemisiae Argyis, 5 gram safflower oils, 5 gram Mentholums and 5 gram Oleum Camphoras and put into 100 ml beakers, stir fast and obtain uniform mixture, thereby make pharmaceutical composition of the present invention.
Embodiment 4
The pharmaceutical composition of embodiments of the invention 1 is administered to 10 tinea unguium patients, once a day, and according to following standard evaluation therapeutic effect.
Evaluation criterion:
Score 1: use and grow new fingernail after 5 days
Score 2: use and grow new fingernail after 10 days
Score 3: use and grow new fingernail after 15 days
Score 4: use and grow new fingernail after 20 days
Score 5: use and grow new fingernail after 25 days
Score 6: use and grow new fingernail after 30 days
| The patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Score | 5 | 2 | 6 | 2 | 3 | 3 | 3 | 4 | 3 | 4 |
Whether 100 days above-mentioned 10 patients of observation tinea unguium still occurs after growing new fingernail simultaneously, and finding only has 1 example to reappear tinea unguium, and tinea unguium no longer appears in all the other 9 routine patients.
Embodiment 5
The pharmaceutical composition of embodiments of the invention 2 is administered to 10 tinea unguium patients, once a day, and according to the evaluation criterion therapeutic effect of embodiment 4.
| The patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Score | 2 | 4 | 3 | 2 | 3 | 4 | 2 | 5 | 3 | 6 |
Whether 100 days above-mentioned 10 patients of observation tinea unguium still occurs after growing new fingernail simultaneously, and finding does not have 1 example to reappear tinea unguium.
Embodiment 6
5 tinea unguium patients (being numbered 1-5) and 5 have tinea pedis history for many years but people's (being numbered I-V) of not having tinea unguium once a day, used 50 days continuously with being administered to respectively of making of embodiment 1.Mark off following standard according to degree easy to break, the elasticity of the transmittance of the fineness of nail surface, fingernail, fingernail and the observation of cutting the fingernail cross section then, the fingernail of estimating the tinea unguium patient with tinea pedis arranged but do not have the people of tinea unguium to use forward and backward corresponding compactness extent.
Evaluation criterion:
Score 1: fingernail is very fine and close
Score 2: fingernail densification
Score 3: fingernail is a bit loose
Score 4: fingernail is very loose
| The patient | 1 | 2 | 3 | 4 | 5 | I | II | III | IV | V |
| Score | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 |
As above table as can be known, it is fine and close that pharmaceutical composition of the present invention can be that fingernail becomes, thereby can effectively prevent tinea unguium.
Comparative example 1
Get 200 gram Flos Caryophyllis (available from the Haozhou, Anhui) and 400 gram Fructus Anisi Stellatis (available from the Haozhou, Anhui) are put into the medicinal cupping that 1 premium on currency is housed, soaked several hours earlier, be heated to 100 ℃ with sharp fire, then with warm fiery the heating 3 hours.Stop to pour out described black liquor after the heating.The black liquor that obtains is administered on 10 tinea unguium patients as described herein, once a day, and estimates therapeutic effect according to the evaluation criterion of embodiment 4.
| The patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Score | 6 | 5 | 0 | 5 | 6 | 4 | 5 | 3 | 6 | 0 |
Annotate: 0 expression does not grow new fingernail.
Whether 30 days above-mentioned 10 patients of observation tinea unguium still occurs after growing new fingernail simultaneously, and finding has 8 examples to reappear tinea unguium.
All quote in this application as a reference at all documents that the present invention mentions, just quoted as a reference separately as each piece document.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after having read above-mentioned teachings of the present invention, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (10)
1. pharmaceutical composition, it comprises the Oleum Caryophylli of 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion.
2. pharmaceutical composition as claimed in claim 1, the consumption that it is characterized in that described Oleum Caryophylli is the 30-50 weight portion, and/or the consumption of described Oleum Anisi Stellati is the 50-70 weight portion.
3. pharmaceutical composition as claimed in claim 1, the consumption that it is characterized in that described Oleum Caryophylli is 40 weight portions, and/or the consumption of described Oleum Anisi Stellati is 60 weight portions.
4. pharmaceutical composition as claimed in claim 1, it also can comprise in safflower oil, Oleum menthae, Oleum Folium Artemisiae Argyi and the Oleum Camphora of 0.5-30 weight portion one or more.
5. pharmaceutical composition as claimed in claim 4, the consumption 0.5-15 weight portion that it is characterized in that described safflower oil, the consumption 0.5-15 weight portion of described Oleum menthae, the consumption of described Oleum Folium Artemisiae Argyi are that the consumption of 0.5-15 weight portion or described Oleum Camphora is the 0.5-15 weight portion.
6. pharmaceutical composition, it is made up of the Oleum Caryophylli of 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion.
7. pharmaceutical composition, one or more are formed in its safflower oil, Oleum menthae, Oleum Folium Artemisiae Argyi and Oleum Camphora by the Oleum Anisi Stellati of the Oleum Caryophylli of 20-60 weight portion, 40-80 weight portion and 0.5-30 weight portion.
8. as the described pharmaceutical composition of claim 1-7, it is characterized in that it is a liquid preparation.
9. method of making the described pharmaceutical composition of claim 1, it comprises the Oleum Caryophylli that mixes the 20-60 weight portion and the Oleum Anisi Stellati of 40-80 weight portion, the pharmaceutical composition that obtains.
The described pharmaceutical composition of claim 1 in preparation treatment tinea unguium, tinea manus and pedis, fungal infection of hand and foot, wet disease, redness, scratch where it itches, the purposes in the medicine of psoriasis and desquamation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510025686 CN1718226A (en) | 2005-05-09 | 2005-05-09 | Medicine composition for treating leuconychia, and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510025686 CN1718226A (en) | 2005-05-09 | 2005-05-09 | Medicine composition for treating leuconychia, and its prepn. method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1718226A true CN1718226A (en) | 2006-01-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510025686 Pending CN1718226A (en) | 2005-05-09 | 2005-05-09 | Medicine composition for treating leuconychia, and its prepn. method |
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| CN (1) | CN1718226A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210809A (en) * | 2011-05-30 | 2011-10-12 | 袁宗保 | Lotion for treating onychomycosis |
| CN103585330A (en) * | 2013-10-22 | 2014-02-19 | 新乡医学院 | Chinese medicinal composition for fungal infection of skin and preparation method thereof |
| CN113181326A (en) * | 2021-05-06 | 2021-07-30 | 卢文庆 | Aromatic external conditioning liquid medicine formula and preparation process thereof |
-
2005
- 2005-05-09 CN CN 200510025686 patent/CN1718226A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210809A (en) * | 2011-05-30 | 2011-10-12 | 袁宗保 | Lotion for treating onychomycosis |
| CN102210809B (en) * | 2011-05-30 | 2012-07-18 | 袁宗保 | Lotion for treating onychomycosis |
| CN103585330A (en) * | 2013-10-22 | 2014-02-19 | 新乡医学院 | Chinese medicinal composition for fungal infection of skin and preparation method thereof |
| CN103585330B (en) * | 2013-10-22 | 2015-08-05 | 新乡医学院 | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof |
| CN113181326A (en) * | 2021-05-06 | 2021-07-30 | 卢文庆 | Aromatic external conditioning liquid medicine formula and preparation process thereof |
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