CN1228080C - Blood activating Chinese medicinal composition in traumatology department and its preparing process - Google Patents
Blood activating Chinese medicinal composition in traumatology department and its preparing process Download PDFInfo
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- CN1228080C CN1228080C CN 200410021717 CN200410021717A CN1228080C CN 1228080 C CN1228080 C CN 1228080C CN 200410021717 CN200410021717 CN 200410021717 CN 200410021717 A CN200410021717 A CN 200410021717A CN 1228080 C CN1228080 C CN 1228080C
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a traditional Chinese medicine compound for treating bone diseases and promoting blood circulation, which is characterized in that the medicine is prepared by the following components: 5 to 15 portions by weight of rhubarb, 4 to 12 portions by weight of raw Sichuan axonite root, 5 to 15 portions by weight of safflower, 0.2 to 1 portions by weight of dragon's blood, 2 to 8 portions by weight of medicinal cyathula root, 4 to 12 portions by weight of Yanhusuo, 4 to 12 portions by weight of raw kusnezoff monkshood root, 0.5 to 2 portions by weight of Chinese honeylocust abnormal fruit, 0.5 to 2 portions by weight of coralbean bark, 3 to 10 portions by weight of dahurian angelica, 4 to 12 portions by weight of shortstalk monkshood root, 2 to 10 portions by weight of hemlock parsley, 0.5 to 5 portions by weight of common vladimiria root, 5 to 15 portions by weight of cotton rose hibiscus leaf, 4 to 12 portions by weight of scutellaria, 5 to 15 portions by weight of phellodendron bark, 0.2 to 1 portions by weight of liquorice, 3 to 9 portions by weight of camenthol, 1 to 5 portions by weight of borneol and 1 to 5 portions by weight of menthol to prepare the product by pulverization, soaking, percolation, mixing, filtration, filling, etc. The traditional Chinese medicine compound has the advantages of simple production and preparation technology, obvious treatment effect, long lasting time and short course of treatment. In addition, the product has the functions for promoting blood circulation, relieving blood stasis and swelling, relieving pain, promoting qi circulation, eliminating dampness and the like, and is used for treating symptoms of local tumidity, pain, hematocyanosis, blood stasis and the like caused by acute closed soft tissue injuries and contusion.
Description
Technical field
The present invention relates to be used to pharmaceutical composition that comes from plant and preparation method thereof, be particularly related to a kind of traumatology Chinese medicine composition and preparation method thereof of invigorating blood circulation, diseases such as product mainly is applicable to the acute closed property of treatment soft tissue sprain clinically, dampen the local swelling that causes, pain, livid purple, ecchymosis fracture.
Background technology
In the prior art, be used for the treatment of acute closed property soft tissue sprain clinically, dampen the local swelling that causes, the medicine of diseases such as pain, livid purple, ecchymosis fracture has bone-setting liquor, repercussive and analgesic tincture, the grieved liniment of gram etc.Bone-setting liquor (see Chinese Pharmacopoeia 2000 version one one), by Mentholum, Radix Aconiti Kusnezoffii, Cauliset Folium Piperis Hancei, Litsea cubeba (Lour.) Persoon, Rhizoma Curcumae, Caulis Entadae, Caulis Piperis Kadsurae, Radix calophylli membranacei, Rhizoma Polygoni Cuspidati, Lignum Dalbergiae Odoriferae, JIULONGCHUAN, Radix Zanthoxyli, Caulis Gneti, Radix Vladimiriae, a thousand pieces of gold dial, broken bone wood, Eupolyphaga Seu Steleophaga, five tastes rattan, Cortex Periplocae, Radix Cinnamomi porrecti, Radix Cynanchi Paniculati, Herba Inulae cappae, Radix araliae armatae, Camphora, Radix Ardisiae Crenatae, Fructus Gleditsiae Abnormalis forms; Product is henna supernatant liquid; Gas fragrance; Have blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, the reducing swelling and alleviating pain function is used for osteopatia sprain, and miscellaneous fracture, dislocation are used before and after the motion, can allaying tiredness.Repercussive and analgesic tincture (seeing newly organized national Chinese patent medicine) is made up of the Radix Angelicae Dahuricae, Mentholum, Lignum Aquilariae Resinatum, Rhizoma Chuanxiong, DALUOSAN, Rhizoma Curcumae, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix seu Caulis Parabarii, Caulis Fibraureae, Herba Schizonepetae, Radix Zanthoxyli, Radix Vladimiriae, Radix Cyathulae, rhizoma sparganic, Cortex Acanthopancis, Herba Asari, Radix Ardisiae punctatae, Radix Cynanchi Paniculati, Camphora, Fructus Gardeniae; Product is filemot supernatant liquid, gas fragrance, acrid in the mouth, hardship; Have relaxing muscles and tendons and activating QI and blood in the collateral, the reducing swelling and alleviating pain function is used for osteopatia sprain, rheumatic ostalgia, innominate toxic swelling, and parotitis swells and ache.Restrain grieved liniment (seeing newly organized national Chinese patent medicine), form by Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Caryophylli, Flos Carthami, Rhizoma Zingiberis Recens, Oleum Terebinthinae, Camphora; Product is the supernatant liquid of rufous; Gas perfume (or spice); Has blood circulation promoting and blood stasis dispelling, the reducing swelling and alleviating pain function; Be used for the acute soft tissue bruise.Though have certain effect during these drug uses, its reducing swelling and alleviating pain, promoting blood circulation to remove blood stasis effect are more undesirable, and onset slow, hold time short, the course of treatment is longer.
Summary of the invention
The present invention's purpose is intended to overcome deficiency of the prior art, provides a kind of reducing swelling and alleviating pain, promoting blood circulation to remove blood stasis effect obvious, and rapid-action, the traumatology long, short treating period of the holding time Chinese medicine composition and preparation method thereof of invigorating blood circulation.
Content of the present invention is: a kind of traumatology Chinese medicine composition of invigorating blood circulation, and its feature part is to be made by following component (weight):
Radix Et Rhizoma Rhei 5-15 part, Radix Aconiti 4-12 part, Flos Carthami 5-15 part,
Sanguis Draxonis 0.2-1 part, Radix Cyathulae 2-8 part, Rhizoma Corydalis 4-12 part,
Radix Aconiti Kusnezoffii 4-12 part, Fructus Gleditsiae Abnormalis 0.5-2 part, Cortex erythrinae 0.5-2 part,
Radix Angelicae Dahuricae 3-10 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-12 part, Rhizoma Chuanxiong 2-10 part,
Radix Vladimiriae 0.5-5 part, Folium Hibisci Mutabilis 5-15 part, Radix Scutellariae 4-12 part,
Cortex Phellodendri 5-15 part, Radix Glycyrrhizae 0.2-1 part, Camphora 3-9 part,
Borneolum Syntheticum 1-5 part and Mentholum 1-5 part.
In the content of the present invention: described Rhizoma Corydalis is Rhizoma Corydalis (processed with vinegar) preferably.
Another content of the present invention is: the invigorate blood circulation preparation method of Chinese medicine composition of a kind of traumatology, and its feature part is mainly to be made up of the following step:
(a) pulverize: described each component is ground into coarse powder;
(b) soak: the component after will pulverizing, the weight ratio amount of getting by Radix Et Rhizoma Rhei 5-15 part, Radix Aconiti 4-12 part, Flos Carthami 5-15 part, Radix Cyathulae 2-8 part, Rhizoma Corydalis 4-12 part, Radix Aconiti Kusnezoffii 4-12 part, Fructus Gleditsiae Abnormalis 0.5-2 part, Cortex erythrinae 0.5-2 part, Radix Angelicae Dahuricae 3-10 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-12 part, Rhizoma Chuanxiong 2-10 part, Radix Vladimiriae 0.5-5 part, Folium Hibisci Mutabilis 5-15 part, Radix Scutellariae 4-12 part, Cortex Phellodendri 5-15 part, Radix Glycyrrhizae 0.2-1 part is mixed, moistening with proper amount of white spirit or ethanol, the percolator of packing into, add Chinese liquor or ethanol again and do not have the mixture surface, placed 48-72 hour;
(c) percolation: mixture is emitted percolate through percolator, and from percolator, constantly replenish Chinese liquor or ethanol, collect percolate;
(d) mix:,,, add in the percolate mixing with proper amount of white spirit or dissolve with ethanol in the ratio amount of getting of Sanguis Draxonis 0.2-1 part, Camphora 3-9 part, Borneolum Syntheticum 1-5 part, Mentholum 1-5 part with Sanguis Draxonis, Borneolum Syntheticum, Camphora, Mentholum four flavors; The 8-12 that Chinese liquor or alcoholic acid total consumption are described each component gross weight times, and make the content range of mixed liquor mesaconitine in every 100ml mixed liquor, contain aconitine 0.1-0.5mg;
(e) filtration, fill: mixed liquor is filtered, get the clean container fill, promptly get product.Through check, packing gets product again.
Described Chinese liquor or alcoholic acid concentration expressed in percentage by volume are 20-80 ℃ preferably.
Described Rhizoma Corydalis is Rhizoma Corydalis (processed with vinegar) preferably.
The present composition can be made the pharmaceutical dosage form of all externals.Promptly adopt other process of the prior art, the traumatology of the present invention Chinese medicine composition of invigorating blood circulation is made the other products form, for example: powder, patch, medicated wine etc.
Compared with prior art, the present invention has following characteristics and effect:
(1) product of the present invention is a medicine for external use, and clinical efficacy obviously is better than kinds such as bone-setting liquor, repercussive and analgesic tincture, the grieved liniment of gram at aspects such as pain relieving, detumescence, promoting blood circulation to remove blood stasis, mainly show as: rapid-action, hold time long, short treating period;
(2) the end product quality standard application 5 kinds of thin layer chromatography discrimination methods, adopted advanced high performance liquid chromatography detection level, formulated clear and definite content limit scope, constant product quality;
(3) production technology adopts and leaches the principle percolation, and process for producing is simple, and raw material is easy to get, and production cost is low, and is practical;
(4) clinical observation on the therapeutic effect result of study: be responsible for tissue by Hospital Affiliated To Chengdu Traditional Chinese Medicine Univ, Chengdu institute of traditional Chinese medicine, Chongqing City institute of traditional Chinese medicine, Chengdu Sports Hospital of the State Physical Culture and Sports Commission and five tame medical institutions of Chengdu Institute of Sport Wounds carry out clinical experimental study, treatment group medicine: the traumatology tincture of invigorating blood circulation; Matched group medicine: bone-setting liquor.
This test actual observation 600 examples, main diseases kind (turn round, dampen) 520 examples wherein, non-main diseases kind (fracture) 80 examples.
Result of the test is: during the main diseases kind was turned round, dampened, obvious effective rate treatment group was 73.08%, and matched group is 62.69%, and there is significant difference P＜0.05, and treatment group obvious effective rate is apparently higher than matched group.The average out to 8.30 days course of treatment of treatment group, matched group average out to 8.85 days, there is significant difference P＜0.05, is significantly shorter than matched group the course of treatment of treatment group.Treatment group clinical recovery time average is 7.19 days, and matched group average time is 7.26 days, and the treatment group clinical recovery time also is shorter than matched group.From medicine pain relieving onset time, main diseases kind treatment group is 73.40 minutes, and matched group is 98.09 minutes, and there is significant difference P＜0.05, and treatment group medicine pain relieving onset time is obviously faster than matched group.
The specific embodiment
Embodiment 1-8:
A kind of traumatology Chinese medicine composition of invigorating blood circulation, its component and composition see the following form:
| Rhizoma Chuanxiong | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 10 |
| Radix Vladimiriae | 0.5 | 1.5 | 2 | 2.5 | 3 | 3.5 | 4.5 | 5 |
| Folium Hibisci Mutabilis | 15 | 13 | 11 | 9 | 7 | 5 | 8 | 10 |
| Radix Scutellariae | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 12 |
| Cortex Phellodendri | 10 | 9 | 15 | 13 | 11 | 9 | 7 | 5 |
| Radix Glycyrrhizae | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 1 |
| Camphora | 9 | 8 | 7 | 6 | 5 | 4 | 3 | 5 |
| Borneolum Syntheticum | 5 | 4.5 | 4 | 3.5 | 3 | 2.5 | 2 | 1 |
| Mentholum | 1 | 2 | 2.5 | 3 | 3.5 | 4 | 4.5 | 5 |
Embodiment 9:
The invigorate blood circulation preparation method of Chinese medicine composition of a kind of traumatology, mainly form by the following step:
(a) pulverize: described each component is ground into coarse powder;
(b) soak: the component after will pulverizing, usefulness by arbitrary example among the embodiment 1-8 is measured Radix Et Rhizoma Rhei, Radix Aconiti, Flos Carthami, Radix Cyathulae, Rhizoma Corydalis, Radix Aconiti Kusnezoffii, Fructus Gleditsiae Abnormalis, Cortex erythrinae, the Radix Angelicae Dahuricae, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Rhizoma Chuanxiong, Radix Vladimiriae, Folium Hibisci Mutabilis, Radix Scutellariae, Cortex Phellodendri and Radix Glycyrrhizae, mix, moistening with proper amount of white spirit or ethanol, the percolator of packing into, add Chinese liquor or ethanol again and do not have the mixture surface, placed 48-72 hour;
(c) percolation: mixture is emitted percolate through percolator, and from percolator, constantly replenish Chinese liquor or ethanol, collect percolate;
(d) mix: with Sanguis Draxonis, Borneolum Syntheticum, Camphora, Mentholum four flavors, the same embodiment of (b) with proper amount of white spirit or dissolve with ethanol, adds in the percolate mixing with the ratio amount of getting of measuring Sanguis Draxonis, Camphora, Borneolum Syntheticum, Mentholum set by step; The 8-12 that Chinese liquor or alcoholic acid total consumption are described each component gross weight times, and make the content range of mixed liquor mesaconitine in every 100ml mixed liquor, contain hypaconitine 0.1-0.5mg;
(e) filtration, fill: mixed liquor is filtered, get the clean container fill, promptly get product.Through check, packing gets product again.
Described Chinese liquor or alcoholic acid concentration expressed in percentage by volume are 20-80 ℃ preferably.
The main quality standard of medicine: it is right to comprise: Radix Et Rhizoma Rhei, Cortex Phellodendri, Rhizoma Corydalis, Radix Aconiti and Borneolum Syntheticum, Camphora, Mentholum thin layer chromatography differentiate, and with the method and the index of HPLC method mensuration hypaconitine, the content limit scope is containing (C
33H
45O
10N) every 100ml0.1-0.5mg.
Function cures mainly: promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, circulation of qi promoting damp eliminating.Be used for acute closed property soft tissue sprain, dampen the local swelling that causes, diseases such as pain, livid purple, ecchymosis.Aspect function cures mainly, its reducing swelling and alleviating pain, the promoting blood circulation to remove blood stasis effect obviously is better than kinds such as bone-setting liquor, repercussive and analgesic tincture, the grieved liniment of gram, mainly shows as: rapid-action, hold time long, short treating period.Clinical efficacy obviously is better than other kind.
Usage and dosage: get this product and be coated with in right amount and put the affected part on the skin, 4 times on the one, or soak deposited affected part with Cotton Gossypii, gauze.Every day, maximum consumption was no more than 20 milliliters, and continuous use must not surpass for two weeks.
Points for attention: 1, this product is a medicine for external use, and certain toxicity is arranged, and is sure not oral.
2, this product should be placed the position that unsuitable for children is got.
3, be sure not contact eye, nose, oral mucosa place.
Embodiment 10:
The invigorate blood circulation preparation method of Chinese medicine composition of a kind of traumatology, mainly form by the following step:
(a) pulverize: described each component is ground into coarse powder;
(b) soak: the component after will pulverizing, the weight proportion amount of getting by Radix Et Rhizoma Rhei 10.5g, Radix Aconiti 7.2g, Flos Carthami 10.5g, Radix Cyathulae 3.6g, Rhizoma Corydalis (vinegar system) 7.2g, Radix Aconiti Kusnezoffii 7.2g, Fructus Gleditsiae Abnormalis 1.3g, Cortex erythrinae 0.7g, Radix Angelicae Dahuricae 3.6g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 3.6g, Rhizoma Chuanxiong 3.6g, Radix Vladimiriae 0.7g, Folium Hibisci Mutabilis 10.5g, Radix Scutellariae 7.2g, Cortex Phellodendri 10.5g, Radix Glycyrrhizae 0.7g is mixed, moistening with 1 times of amount ethanol, the percolator of packing into, add ethanol again and do not have the mixture surface, placed 48 hours;
(c) percolation: mixture is emitted percolate through percolator, and from percolator, constantly replenish ethanol, collect the about 600ml of percolate;
(d) mix: with Sanguis Draxonis, Borneolum Syntheticum, Camphora, Mentholum four flavors, by the weight proportion amount of getting of Sanguis Draxonis 0.36g, Camphora 6g, Borneolum Syntheticum 2.8g, Mentholum 2.4g, with about 100ml dissolve with ethanol, add in the percolate, mixing is made 700ml;
(e) filtration, fill: mixed liquor is filtered, get the clean container fill, promptly get product.Through check, packing gets product again.
Described alcoholic acid temperature concentration expressed in percentage by volume is 20-80 ℃ preferably.
Target level of product quality adopts high effective liquid chromatography for measuring hypaconitine content, and its limits is defined as 0.1-0.5mg/100ml, and detects Radix Et Rhizoma Rhei, Cortex Phellodendri, Rhizoma Corydalis, Radix Aconiti and Borneolum Syntheticum, Camphora, Mentholum with thin layer chromatography.
The function of present embodiment product cures mainly, usage and dosage and points for attention are equal to embodiment 9, omits.
This product clinical efficacy is better than bone-setting liquor in its effects of aspect such as pain relieving, detumescence, dissipating blood stasis, shows as rapid-action, effect long, the short treating period of holding time.
The invention is not restricted to the foregoing description, content of the present invention is described all can be implemented, and has good result.
Claims (6)
1, a kind of traumatology Chinese medicine composition of invigorating blood circulation is characterized in that being made by following materials of weight proportions medicine:
Radix Et Rhizoma Rhei 5-15 part, Radix Aconiti 4-12 part, Flos Carthami 5-15 part,
Sanguis Draxonis 0.2-1 part, Radix Cyathulae 2-8 part, Rhizoma Corydalis 4-12 part,
Radix Aconiti Kusnezoffii 4-12 part, Fructus Gleditsiae Abnormalis 0.5-2 part, Cortex erythrinae 0.5-2 part,
Radix Angelicae Dahuricae 3-10 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-12 part, Rhizoma Chuanxiong 2-10 part,
Radix Vladimiriae 0.5-5 part, Folium Hibisci Mutabilis 5-15 part, Radix Scutellariae 4-12 part,
Cortex Phellodendri 5-15 part, Radix Glycyrrhizae 0.2-1 part, Camphora 3-9 part,
Borneolum Syntheticum 1-5 part and Mentholum 1-5 part.
2, by the described traumatology of claim 1 Chinese medicine composition of invigorating blood circulation, it is characterized in that: described Rhizoma Corydalis is a Rhizoma Corydalis (processed with vinegar).
3, by the invigorate blood circulation preparation method of Chinese medicine composition of the described traumatology of claim 1, it is characterized in that mainly forming by the following step:
(a) pulverize: described each crude drug is ground into coarse powder;
(b) soak: the crude drug after will pulverizing, the weight ratio amount of getting by Radix Et Rhizoma Rhei 5-15 part, Radix Aconiti 4-12 part, Flos Carthami 5-15 part, Radix Cyathulae 2-8 part, Rhizoma Corydalis 4-12 part, Radix Aconiti Kusnezoffii 4-12 part, Fructus Gleditsiae Abnormalis 0.5-2 part, Cortex erythrinae 0.5-2 part, Radix Angelicae Dahuricae 3-10 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-12 part, Rhizoma Chuanxiong 2-10 part, Radix Vladimiriae 0.5-5 part, Folium Hibisci Mutabilis 5-15 part, Radix Scutellariae 4-12 part, Cortex Phellodendri 5-15 part, Radix Glycyrrhizae 0.2-1 part is mixed, moistening with proper amount of white spirit or ethanol, the percolator of packing into, add Chinese liquor or ethanol again and do not have the mixture surface, placed 48-72 hour;
(c) percolation: mixture is emitted percolate through percolator, and from percolator, constantly replenish Chinese liquor or ethanol, collect percolate;
(d) mix:,,, add in the percolate mixing with proper amount of white spirit or dissolve with ethanol in the ratio amount of getting of Sanguis Draxonis 0.2-1 part, Camphora 3-9 part, Borneolum Syntheticum 1-5 part, Mentholum 1-5 part with Sanguis Draxonis, Borneolum Syntheticum, Camphora, Mentholum four flavors; The 8-12 that Chinese liquor or alcoholic acid total consumption are described each crude drug gross weight times, and make the content range of mixed liquor mesaconitine in every 100ml mixed liquor, contain aconitine 0.1-0.5mg;
(e) filtration, fill: mixed liquor is filtered, get the clean container fill, promptly get product.
4, by the invigorate blood circulation preparation method of Chinese medicine composition of the described traumatology of claim 3, it is characterized in that: described Chinese liquor or alcoholic acid concentration expressed in percentage by volume are 20-80%.
5, by the invigorate blood circulation preparation method of Chinese medicine composition of claim 3 or 4 described traumatologys, it is characterized in that: described Rhizoma Corydalis is a Rhizoma Corydalis (processed with vinegar).
6, by the described traumatology of claim 1 Chinese medicine composition of invigorating blood circulation, it is characterized in that: said composition is made the pharmaceutical dosage form of external.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021717 CN1228080C (en) | 2004-01-19 | 2004-01-19 | Blood activating Chinese medicinal composition in traumatology department and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021717 CN1228080C (en) | 2004-01-19 | 2004-01-19 | Blood activating Chinese medicinal composition in traumatology department and its preparing process |
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| CN1228080C true CN1228080C (en) | 2005-11-23 |
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| CN103599289A (en) * | 2013-10-21 | 2014-02-26 | 姜席赋 | Traditional Chinese medicine formula of edema-relieving powder |
| CN106248858B (en) * | 2016-08-30 | 2018-06-19 | 贵阳中医学院第二附属医院 | The quality determining method of one seedling medicine traumatology analgesic solution |
| CN106619854A (en) * | 2016-11-28 | 2017-05-10 | 马志恒 | External traditional Chinese medicine composition for treating haemorrhoids |
| CN110123950A (en) * | 2019-07-03 | 2019-08-16 | 黄锡锋 | A kind of promoting blood circulation and stopping pain Stenoloma chusana liquid medicine and its brewing method |
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