CN1857697A - Compound Chinese medicine Anxuekang and its preparing method - Google Patents
Compound Chinese medicine Anxuekang and its preparing method Download PDFInfo
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Abstract
The present invention provides a compound Chinese medicine Anxuekang prepared with natural plant material and for treating leukemia and its preparation process. It is prepared with astragalus root, angelica, white peony root, Chuanxiong rhizome, dodder seed and other five kinds of Chinese medicinal materials in certain weight proportion. The preparation process includes the steps of: mixing and crushing the materials, water extracting, sieving, adding additive, filtering, concentrating filtrate to water content of 60%, and ultraviolet sterilizing. The present invention has high curative effect on leukemia and no toxic side effect.
Description
Technical field
The present invention relates to medicine field, relating in particular to a kind of is being used for the treatment of of feedstock production leukemic herbal mixture Anxuekang and preparation method thereof with the natural plant.
Background technology
Leukemia is commonly called as leukemia, is leukocytic malignant change in the blood of human body.Its pathological characters is leukaemia's paraplasm to be arranged in bone marrow and hemopoietic tissue widely and soak into other histoorgan.Influence the normal hematopoiesis of normal hematopoiesis tissue owing to unusual leukaemia's hypertrophy.Clinical often have signs such as anemia, heating, hemorrhage and liver, splenic lymph nodes enlargement.At China's sickness rate is 2-4 people/100,000, is mainly in child and youth, and mortality rate is high, its serious threat patient's life.Doctor trained in Western medicine generally adopts chemotherapy at present, and the toxic and side effects that chemotherapy produced to the human body infringement greatly, and the patient often can not get satisfied effect, but causes adverse consequencess such as health immunologic hypofunction on the contrary; And the employing hematopoietic stem cell transplantation, owing to blood group, hereditary DNA difference, the interpersonal rate that mixes is lower, thereby brings great difficulty to operation, and its expense is also very high, and it is the difficult problem together in face of the puzzlement medical personnel.For avoiding the defective of western medical treatment, medical circles release herbal composite and treat leukemic scheme in China.
Summary of the invention
Technical problem to be solved by this invention is: based on understanding and the Therapeutic Principle of motherland's medical science to treatment leukemia mechanism, with reference to the modern pharmacology achievement, provide a kind of leukemia and herbal mixture Anxuekang and preparation method thereof fast and effectively of being used for the treatment of.
The present invention solves its technical problem and adopts following technical scheme:
Provided by the inventionly be used for the treatment of leukemic herbal mixture Anxuekang, its combination formula is mainly made by the raw material of following weight portion: 5～30 parts of the Radixs Astragali, 10～25 parts of Radix Angelicae Sinensis, 5～25 parts of the Radix Paeoniae Albas, 5～10 parts of Rhizoma Chuanxiongs, 10～20 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 5～10 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 5～10 parts of Radix Panacis Quinquefoliis.
The above-mentioned method that is used for the treatment of leukemic herbal mixture Anxuekang of preparation provided by the invention, it may further comprise the steps:
Raw material is mixed pulverizing according to the above ratio, the water extraction 2～3 times that adds 5～10 times of weight, each 1.5～2 hours, 10～200 orders that sieve add medicated premix, mixing, after sieve 10～200 orders, filtrate slow fire is concentrated into water content 60%, through the ultraviolet sterilization, promptly can be made into leukemic herbal mixture Anxuekang of being used for the treatment of of various dosage forms.
The present invention compared with prior art has following main beneficial effect:
One. can treat leukemia, be natural drug, form by the theory of Chinese medical science prescription.
They are two years old. this efficacy of drugs: blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, pungent drugs can disperse and bitter drugs can descend, heat-clearing and toxic substances removing, liver and kidney tonifying, set upright rise white.Leukemia there is excellent curative, has no side effect.
They are three years old. and this medicine can effectively promote patient's cells in vivo, hemoglobin to recover, and accelerates the proliferation and differentiation effect of hematopoietic stem cell and bone marrow hemopoietic progenitor cell of red blood cell line, is that the growth of CFU-GM has facilitation to grain, therefore can reach the purpose of clinical cure.
They are four years old. and this medicine can be made into the dosage form of saying on any pharmaceutics, especially is honey pill agent, capsule, powder, tablet, electuary, oral liquid, also can utilize modern preparation technique to make slow release, controlled release preparation.
Description of drawings
Accompanying drawing is the releasing curve diagram of astragaloside in embodiment 6 nano-drug preparations.
The specific embodiment
Herbal mixture Anxuekang provided by the invention is according to compatibility foundation and test effect, and its combination formula has following several:
Embodiment 1. is mainly made by the raw material of following weight portion:
5～30 parts of the Radixs Astragali, 10～25 parts of Radix Angelicae Sinensis, 5～25 parts of the Radix Paeoniae Albas, 5～10 parts of Rhizoma Chuanxiongs, 10～20 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 5～10 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 5～10 parts of Radix Panacis Quinquefoliis.
Embodiment 2. also has the raw material of following weight parts on the basis of embodiment 1: 0～30 part of Radix Pseudostellariae, 0～20 part in Radix Rehmanniae Preparata, 0～15 part of the Cortex Eucommiae, 0～30 part of Fructus Lycii, 0～15 part of Caulis Spatholobi, 0～30 part of the Rhizoma Atractylodis Macrocephalae.
Embodiment 3. herbal mixture Anxuekangs can be made by the raw material of following weight portion:
20 parts of the Radixs Astragali, 13 parts of Radix Angelicae Sinensis, 16 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Chuanxiongs, 13 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 8 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 7 parts of Radix Panacis Quinquefoliis, 17 parts of Radix Pseudostellariaes, 15 parts in Radix Rehmanniae Preparata, 9 parts of the Cortexs Eucommiae, 16 parts of Fructus Lyciis, 8 parts of Caulis Spatholobis, 22 parts of the Rhizoma Atractylodis Macrocephalaes.
Above-mentioned herbal mixture Anxuekang, its monarch drug are the Radix Astragali, Radix Pseudostellariae, Radix Angelicae Sinensis; Ministerial drug is the Radix Paeoniae Alba, Rhizoma Chuanxiong, Semen Cuscutae, Radix Rehmanniae Preparata; Adjuvant drug is Caulis Spatholobi, the Cortex Eucommiae, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae; Messenger drug is: Colla Corii Asini, Fructus Jujubae, Rhizoma Cyperi, Rhizoma Zingiberis Preparatum, Radix Panacis Quinquefolii.
The compatibility of herbal mixture Anxuekang of the present invention is according to as follows:
Radix Astragali nature and flavor: sweet, tepor, return the spleen lung meridian, have tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, the effect of holder skin ulcer granulation promoting.Cure mainly various asthenia of qi and bloods and exterior deficiency spontaneous perspiration, benefiting vital QI and blood etc.
The Radix Pseudostellariae nature and flavor: sweetness and bitterness, tepor have the tonifying the lung spleen invigorating.Cure mainly: the cough due to deficiency of the lung, the empty lack of appetite of spleen spirit, the cardiopalmus spontaneous perspiration, spirit is tired etc.
Radix Angelicae Sinensis nature and flavor: Gan Xin, temperature are returned liver, the heart, spleen channel, have enrich blood, invigorate blood circulation, the effect of regulating menstruation, pain relieving intestine moistening.Cure mainly: the heart, liver blood are considered, blood circulation promoting and blood stasis dispelling, ulcer sores, reducing swelling and alleviating pain etc.
Radix Paeoniae Alba nature and flavor: picric acid, cold.The soft pulse that nourishes blood, slow in pain relieving, yin fluid astringing is received antiperspirant.Cure mainly: breast abdominal rib pain, dysentery stomachache, spontaneous sweating, fever due to yin deficiency etc.
The Rhizoma Chuanxiong nature and flavor: hot, warm, activating QI to alleviate the depression, timid wind-dryness is wet, promoting blood circulation and stopping pain.Cure mainly: air-cooled headache is dizzy, and the costalgia abdomen is painful, paralysis spasm, ulcer sores etc.
The Semen Cuscutae nature and flavor: property is sweet, flat, invigorating the liver and kidney, and beneficial marrow makes eye bright.Cure mainly: soreness of waist and knee joint, seminal emission, dripping urination, order is dark etc.
The Radix Rehmanniae Preparata nature and flavor: sweet, tepor, YIN nourishing is enriched blood.Cure mainly: deficiency of YIN insufficiency of blood, waist knee flaccidity, the consumptive disease hectic fever due to YIN-deficiency of coughing, seminal emission, metrorrhagia, blurred vision etc.
Caulis Spatholobi nature and flavor: bitter sweet.Temperature is invigorated blood circulation, Shujin.Cure mainly: soreness of waist and knee joint, paralysis and numbness etc.
Cortex Eucommiae nature and flavor: sweet, little suffering, temperature, invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Cure mainly: the spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is desired to fall, hypertension etc.
The Fructus Lycii nature and flavor: sweet, flat, nourishing kidney, lung moistening, tonifying liver makes eye bright, and cures mainly hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, cough due to consumptive disease is quenched one's thirst, seminal emission etc.
Rhizoma Atractylodis Macrocephalae nature and flavor: bitter, warm, spleen reinforcing, stomach reinforcing, dampness and in.Cure mainly: insufficiency of the spleen weakness of QI, anorexia, the asthenia weak breath, void rises, and has loose bowels phlegm retention, edema, dizziness etc.
The Colla Corii Asini nature and flavor: sweet, flat, nourishing YIN and supplementing blood, antiabortive.Cure mainly: blood deficiency, cough due to consumptive disease is spitted blood menoxenia etc.
The Fructus Jujubae nature and flavor: sweet, warm, the spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid is separated poison of drug.Cure mainly: the insufficiency of stomach lack of appetite, just clear a little less than the spleen, insufficiency of vital energy and blood etc.
The Rhizoma Cyperi nature and flavor: hot little hardship is sweet, flat, the resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Cure mainly: incoordination between the liver and stomach, depression of QI, breast abdomen side of body rib goes up painful phlegm retention feeling of fullness, menoxenia, bleeding not during menses etc.
Rhizoma Zingiberis Preparatum nature and flavor: Xin Wen delivers cold expelling, dampness removing reduce phlegm, whet the appetite preventing or arresting vomiting, detoxifcation.Cure mainly: the middle deficiency of vital energy is cold etc.
Radix Pseudostellariae nature and flavor: sweetness and bitterness, tepor, tonifying the lung, spleen invigorating.Cure mainly: cough due to deficiency of the lung, cardiopalmus spontaneous perspiration, insufficiency of the spleen lack of appetite.
Radix Panacis Quinquefolii nature and flavor: sweet little hardship, cold, lung benefiting the moon, clear asthenic fire, promoting the production of body fluid to quench thirst.Cure mainly: deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired tired etc.
The Radix Astragali is enriched blood and the Radix Pseudostellariae compatibility can be nursed one's health the spleen lung, the QI invigorating detumescence.Mix Radix Angelicae Sinensis, Colla Corii Asini again, the blood yiqi curative effect is better.Mix the Radix Paeoniae Alba, Rhizoma Chuanxiong, Semen Cuscutae, can further transfer the gas of enriching blood, lung moistening, nourishing kidney.Being equipped with Rhizoma Zingiberis Preparatum, Radix Panacis Quinquefolii again can detoxifcation, removing dampness, enhancing immunity.Be equipped with Caulis Spatholobi, the Cortex Eucommiae, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae again and can advance a few auxiliary treatment.
But this medicine blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, pungent drugs can disperse and bitter drugs can descend, heat-clearing and toxic substances removing, liver and kidney tonifying, set upright and rise whitely, strengthen body immunity.Various raw materials are compatibility together, can synergism, complementation is helped each other, the property of medicine of each flavor medicine is all performed to and extremely, can effectively promote patient's cells in vivo, hemoglobin to recover, accelerating the proliferation and differentiation effect of hematopoietic stem cell and bone marrow hemopoietic progenitor cell of red blood cell line, is that the growth of CFU-GM has facilitation to grain, to reach the leukemic effect of clinical cure.Be equipped with the use of various pharmaceutical formulations, more can cure leukemia fast and effectively.
The invention provides the preparation method of herbal mixture Anxuekang, it may further comprise the steps: raw material is mixed by aforementioned ratio pulverize, add the water extraction 2～3 times of 5～10 times of weight, each 1.5～2 hours, 10～200 orders sieved, add medicated premix, mixing, after sieve 10～200 orders, filtrate slow fire is concentrated into water content 6O%, through ultraviolet sterilization 25～35min, promptly can be made into leukemic herbal mixture Anxuekang of being used for the treatment of of various dosage forms.
Medicated premix can adopt syrup, Fructus Citri Limoniae essence etc.
Herbal mixture Anxuekang of the present invention, its dosage form can be: dosage forms such as honey pill agent, capsule, powder, tablet, electuary, oral liquid, slow release or controlled release preparation.
Below in conjunction with three embodiment preparation method of the present invention is described further.
Embodiment 4: the preparation of electuary
Take by weighing each component (kg) by following proportioning: the Radix Astragali 5, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 5, Rhizoma Chuanxiong 10, Semen Cuscutae 10, Colla Corii Asini 10, Fructus Jujubae 10, Rhizoma Cyperi 10, Rhizoma Zingiberis Preparatum 5, Radix Panacis Quinquefolii 10.
Preparation method may further comprise the steps: get described raw material, be mixed in proportion, add the water extraction 3 times of 5 times of weight, each 2 hours, 95% ethanol extraction 3 times that adds 5 times of weight again, each 2 hours, merge extractive liquid, concentrated, spray drying, pack, ultraviolet sterilization 30min, promptly.
Embodiment 5: the preparation of oral liquid
Take by weighing each component (kg) by following proportioning: the Radix Astragali 30, Radix Angelicae Sinensis 10, the Radix Paeoniae Alba 25, Rhizoma Chuanxiong 5, Semen Cuscutae 20, Colla Corii Asini 10, Fructus Jujubae 10, Rhizoma Cyperi 5, Rhizoma Zingiberis Preparatum 5, Radix Panacis Quinquefolii 5,30 parts of Radix Pseudostellariaes, 20 parts in Radix Rehmanniae Preparata, 15 parts of the Cortexs Eucommiae, 30 parts of Fructus Lyciis, 15 parts of Caulis Spatholobis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, syrup 5, Fructus Citri Limoniae essence 1.
Preparation method may further comprise the steps: get above-mentioned raw materials, be mixed in proportion, add the water extraction 3 times of 10 times of weight, each 1.5 hours, 120 mesh sieve filters filter, add syrup, Fructus Citri Limoniae essence, mixing, 120 mesh sieves filter, filtrate slow fire is concentrated into water content 60%, embedding is in the 15ml oral liquid bottle, with 120 degrees centigrade of 20min flowing steam sterilizations, promptly.
Embodiment 6: the preparation of Nano medication microsphere
Take by weighing each component (kg) by following proportioning: 20 parts of the Radixs Astragali, 13 parts of Radix Angelicae Sinensis, 16 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Chuanxiongs, 13 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 8 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 7 parts of Radix Panacis Quinquefoliis.17 parts of Radix Pseudostellariaes, 15 parts in Radix Rehmanniae Preparata, 9 parts of the Cortexs Eucommiae, 16 parts of Fructus Lyciis, 8 parts of Caulis Spatholobis, 22 parts of the Rhizoma Atractylodis Macrocephalaes.
Preparation method may further comprise the steps: be mixed in proportion, the water extraction 3 times that adds 8 times of weight, each 2 hours, add 95% ethanol extraction 3 times of 8 times of weight again, each 2 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 50 times of weight of fluid extract again, after the 2-propylene glycol fully dissolves, the chitosan magnetic force of weight such as adding fluid extract stirs 30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying is bottled to powder, and ultraviolet sterilization 30min gets final product.
The assay of this compound recipe Anxuekang preparation effective ingredient astragaloside (Astragaloside IV) is pressed the standards of pharmacopoeia method and is measured.
The instrument of the assay of astragaloside and condition determination: Tianjin, island LC-10AT high performance liquid chromatograph, SPD-10Avp UV, visible light detector, the U-3400 of Hitachi type spectrophotometer.Chromatographic condition: Tianjin, island VP-ODS chromatographic column (150L * 4.6), mobile phase are acetonitrile 20.04% phosphoric acid (35: 65), 40 ℃ of column temperatures, and flow velocity 1ml/min, the detection wavelength is 203nm.
The mensuration of sample release performance: get this compound recipe Anxuekang Nano medication microsphere, measure each Astragaloside content in sample constantly, draw release profiles (seeing accompanying drawing) by official method.
Nano microsphere has slow-release function, has reduced number of times and consumption that the patient takes medicine, greatly reduces patient's misery and the difficulty of taking medicine, and this Nano medication microsphere release rate in 72 hours reaches 100%, so only need take medicine every day and get final product for 1 time.
Nano microsphere self by chitosan and sodium tripolyphosphate preparation has antibacterial action, has increased the compound recipe Anxuekang to leukemic therapeutic effect.
The growth of Anxuekang energy good restraining K562 erythroleukemia cell of the present invention, the Anxuekang electuary of 0.5mg/ml is 71.6% to the growth inhibition ratio of K562 cell; 0.5mg/ml the Nano medication microsphere of Anxuekang to the growth inhibition ratio of K562 cell then up to 86.3%.Above data prove absolutely the leukemic possibility of the healing of Anxuekang.
The toxicity test of herbal mixture Anxuekang of the present invention:
Press the 600g/kg dosed administration through the Kunming mouse gastric infusion, observed seven days, do not see the overt toxicity reaction, no animal dead is not measured median lethal dose(LD 50), and its maximum dosage-feeding is 600g/kg.
One of we think that Anxuekang is that to treat the leukemia effect at present better, and the leukemic medicine of treatment that has no side effect.
Claims (9)
1. herbal mixture Anxuekang is characterized in that its combination formula mainly made by the raw material of following weight portion: 5～30 parts of the Radixs Astragali, 10～25 parts of Radix Angelicae Sinensis, 5～25 parts of the Radix Paeoniae Albas, 5～10 parts of Rhizoma Chuanxiongs, 10～20 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 5～10 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 5～10 parts of Radix Panacis Quinquefoliis.
2. herbal mixture Anxuekang according to claim 1 is characterized in that the raw material of following weight parts in addition: 0～30 part of Radix Pseudostellariae, 0～20 part in Radix Rehmanniae Preparata, 0～15 part of the Cortex Eucommiae, 0～30 part of Fructus Lycii, 0～15 part of Caulis Spatholobi, 0～30 part of the Rhizoma Atractylodis Macrocephalae.
3. herbal mixture Anxuekang according to claim 1 is characterized in that being made by the raw material of following weight portion: 20 parts of the Radixs Astragali, 13 parts of Radix Angelicae Sinensis, 16 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Chuanxiongs, 13 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 8 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 7 parts of Radix Panacis Quinquefoliis, 17 parts of Radix Pseudostellariaes, 15 parts in Radix Rehmanniae Preparata, 9 parts of the Cortexs Eucommiae, 16 parts of Fructus Lyciis, 8 parts of Caulis Spatholobis, 22 parts of the Rhizoma Atractylodis Macrocephalaes.
4. the preparation method of herbal mixture Anxuekang, it is characterized in that may further comprise the steps: raw material is mixed in proportion pulverizing, adds the water extraction 2～3 times of 5～10 times of weight, each 1.5～2 hours, 10～200 orders sieve, add medicated premix, mixing is after sieve 10～200 orders, filtrate slow fire is concentrated into water content 60%, through ultraviolet sterilization 25～35min, promptly can be made into leukemic herbal mixture Anxuekang of being used for the treatment of of various dosage forms
The combination formula of this medicine is mainly made by the raw material of following weight portion: 5～30 parts of the Radixs Astragali, 10～25 parts of Radix Angelicae Sinensis, 5～25 parts of the Radix Paeoniae Albas, 5～10 parts of Rhizoma Chuanxiongs, 10～20 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 5～10 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 5～10 parts of Radix Panacis Quinquefoliis.
5. the preparation method of herbal mixture Anxuekang according to claim 4 is characterized in that its combination formula also has the raw material of following weight parts: 0～30 part of Radix Pseudostellariae, 0～20 part in Radix Rehmanniae Preparata, 0～15 part of the Cortex Eucommiae, 0～30 part of Fructus Lycii, 0～15 part of Caulis Spatholobi, 0～30 part of the Rhizoma Atractylodis Macrocephalae.
6. the preparation method of herbal mixture Anxuekang according to claim 4 is characterized in that being made by the raw material of following weight portion: 20 parts of the Radixs Astragali, 13 parts of Radix Angelicae Sinensis, 16 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Chuanxiongs, 13 parts of Semen Cuscutae, 10 parts in Colla Corii Asini, 10 parts in Fructus Jujubae, 8 parts of Rhizoma Cyperis, 5 parts of Rhizoma Zingiberis Preparatums, 7 parts of Radix Panacis Quinquefoliis, 17 parts of Radix Pseudostellariaes, 15 parts in Radix Rehmanniae Preparata, 9 parts of the Cortexs Eucommiae, 16 parts of Fructus Lyciis, 8 parts of Caulis Spatholobis, 22 parts of the Rhizoma Atractylodis Macrocephalaes.
7. the preparation method of herbal mixture Anxuekang according to claim 4, it is characterized in that: the water extraction 3 times that adds 8 times of weight, each 2 hours, add 95% ethanol extraction 3 times of 8 times of weight again, each 2 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 50 times of weight of fluid extract again, after the 2-propylene glycol fully dissolves, the chitosan magnetic force of weight such as adding fluid extract stirs 30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying is bottled to powder, and ultraviolet sterilization 30min gets final product.
8. the preparation method of herbal mixture Anxuekang according to claim 4 is characterized in that: medicated premix is syrup, Fructus Citri Limoniae essence.
9. the preparation method of herbal mixture Anxuekang according to claim 4 is characterized in that: the dosage form of herbal mixture Anxuekang is honey pill agent, capsule, powder, tablet, electuary, oral liquid, slow release or controlled release preparation.
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| CNB2006100185060A CN100534524C (en) | 2006-03-09 | 2006-03-09 | Compound Chinese medicine Anxuekang and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843891B (en) * | 2009-03-27 | 2012-06-06 | 哈药集团制药六厂 | Blood tonifying composition |
| CN103301211A (en) * | 2013-06-14 | 2013-09-18 | 袁军清 | Traditional Chinese medicine for treating leukopenia |
| CN105362692A (en) * | 2015-12-02 | 2016-03-02 | 钊桂英 | Preparation for treating acute leukemia and preparation method |
| CN105902604A (en) * | 2016-05-20 | 2016-08-31 | 武汉理工大学 | Compound medicament for treating T-cell acute lymphoblastic leukemia (T-ALL) |
| CN108992658A (en) * | 2018-10-24 | 2018-12-14 | 王鉨锬 | It is a kind of for treating the Chinese materia medica preparation of leukaemia |
-
2006
- 2006-03-09 CN CNB2006100185060A patent/CN100534524C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843891B (en) * | 2009-03-27 | 2012-06-06 | 哈药集团制药六厂 | Blood tonifying composition |
| CN103301211A (en) * | 2013-06-14 | 2013-09-18 | 袁军清 | Traditional Chinese medicine for treating leukopenia |
| CN103301211B (en) * | 2013-06-14 | 2015-05-13 | 袁军清 | Traditional Chinese medicine for treating leukopenia |
| CN105362692A (en) * | 2015-12-02 | 2016-03-02 | 钊桂英 | Preparation for treating acute leukemia and preparation method |
| CN105902604A (en) * | 2016-05-20 | 2016-08-31 | 武汉理工大学 | Compound medicament for treating T-cell acute lymphoblastic leukemia (T-ALL) |
| CN105902604B (en) * | 2016-05-20 | 2020-02-18 | 武汉理工大学 | Compound medicine for treating acute T lymphocyte leukemia |
| CN108992658A (en) * | 2018-10-24 | 2018-12-14 | 王鉨锬 | It is a kind of for treating the Chinese materia medica preparation of leukaemia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100534524C (en) | 2009-09-02 |
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