CN114081938B - Bee therapy patch and preparation method thereof - Google Patents

Bee therapy patch and preparation method thereof Download PDF

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Publication number
CN114081938B
CN114081938B CN202111606014.4A CN202111606014A CN114081938B CN 114081938 B CN114081938 B CN 114081938B CN 202111606014 A CN202111606014 A CN 202111606014A CN 114081938 B CN114081938 B CN 114081938B
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parts
bee
powder
weight
patch
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CN114081938A (en
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杨国泉
洪德兴
洪燕
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Hangzhou Dexing Apiculture Co ltd
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Hangzhou Dexing Apiculture Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/10—Peat; Amber; Turf; Humus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a bee therapy patch and a preparation method thereof, wherein the bee therapy patch is prepared from three raw materials, namely plaster matrix, traditional Chinese medicine powder and medicine promoter in a weight ratio of (4-8.8): 0.7-1.9): 1: the plaster matrix is prepared from the following components in parts by weight: 200 portions and 300 portions of tung oil; 30-50 parts of plum blossom Adonis amurensis; 300 portions of amber powder; 10-20 parts of beeswax; 5-10 parts of propolis; 5-10 parts of bee dry powder; the traditional Chinese medicine powder comprises the following components in parts by weight: 30-45 parts of glabrous greenbrier rhizome; 2-2.5 parts of radix aconiti; 2-2.5 parts of kusnezoff monkshood root; 3-3.5 parts of cinnamon; 6.5-7 parts of short-pedicel aconite root; 6-7 parts of radix angelicae pubescentis; 7.5-8.5 parts of divaricate saposhnikovia root; 12-13 parts of parasitic loranthus; 3-4 parts of coptis chinensis; 7.5-8.5 parts of phellodendron; 9-10 parts of rhizoma cibotii; 80-120 parts of a medicinal promoter, wherein the medicinal promoter is at least one of camphor and borneol; the bee therapy patch has good effects of dehumidifying and relieving pain.

Description

Bee therapy patch and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a bee therapy patch and a preparation method thereof.
Background
The conventional plaster is a plaster which is usually stuck to a certain part of a body. The Chinese medicinal materials are prepared into paste, and the paste is spread on a backing material to prepare an external preparation which is mainly used for treating sore and furuncle, eliminating swelling and pain and the like.
With the development of times, the raw materials of the plaster are added with other beneficial substances besides more traditional Chinese medicine materials, so that the effects of diminishing inflammation, promoting blood circulation to remove blood stasis and the like of the plaster are further enhanced. One of them is bee therapy paste. The bee therapy patch is a plaster patch prepared by adding bee products such as beeswax into traditional Chinese medicinal materials, and the beeswax is natural, so that the bee therapy patch has low irritation to skin and good use feeling.
Through the related technologies, the existing plaster in the market cannot achieve better dehumidification and pain relief effects due to the problems of poor medicine absorption degree, short medicine effect and the like.
Disclosure of Invention
In order to enhance the performance of the bee therapy patch in dehumidifying and relieving pain, the application provides the bee therapy patch and the preparation method thereof.
In a first aspect, the application provides a bee therapy patch, which adopts the following technical scheme:
a bee therapy patch is prepared from three components, namely plaster matrix, traditional Chinese medicine powder and medicinal promoter according to the weight ratio of (4-8.8) to (0.7-1.9) to 1:
the plaster matrix is prepared from the following components in parts by weight:
200 portions and 300 portions of tung oil;
30-50 parts of plum blossom Adonis amurensis pill;
300 portions of amber powder;
10-20 parts of beeswax;
5-10 parts of propolis;
5-10 parts of bee dry powder;
the traditional Chinese medicine powder comprises the following components in parts by weight:
30-45 parts of glabrous greenbrier rhizome;
2-2.5 parts of monkshood;
2-2.5 parts of kusnezoff monkshood root;
3-3.5 parts of cinnamon;
6.5-7 parts of short-pedicel aconite root;
6-7 parts of radix angelicae pubescentis;
7.5-8.5 parts of divaricate saposhnikovia root;
12-13 parts of parasitic loranthus;
3-4 parts of coptis chinensis;
7.5-8.5 parts of phellodendron;
9-10 parts of rhizoma cibotii;
the weight portion of the drug accelerator is 80-120 parts, and the drug accelerator is at least one of camphor and borneol.
By adopting the technical scheme, the bee therapy patch consists of a plaster matrix, traditional Chinese medicine powder and a medicine promoter, wherein the plaster matrix is used as a carrier of the traditional Chinese medicine powder and can be used for effectively adhering the prepared bee therapy patch to the skin surface of a patient; the Chinese medicinal powder can be used for enhancing the effects of the patch in eliminating dampness, relieving pain, promoting blood circulation, removing blood stasis, and dredging meridian passage; the medicinal promoter is used for effectively promoting the absorption of plaster matrix and Chinese medicinal powder. Tung oil and amber powder are adopted as main raw materials of the plaster matrix, and a film is formed on the surface of the bee therapy patch, so that the seepage condition is reduced, the viscosity is increased, the application time is prolonged, and the medicine absorption degree and the application comfort level are improved; propolis is a sticky substance formed by mixing plant resin collected by worker bees with secretions such as jawbone and cerifera; beeswax is a mixture of the secretions of the worker bee wax gland and the palate gland. Heating honeycomb in water, filtering, condensing to obtain wax; the bee dry powder is dry powder of bee imago. Drying and pulverizing healthy adult worker bee to obtain powder. Propolis, beeswax and bee dry powder are added into the plaster substrate and are matched with tung oil and amber powder, so that the bee therapy plaster has good dampness eliminating and pain relieving effects; the plum blossom bonesetting pill is matched with propolis, beeswax, bee dry powder and the like, so that the dehumidifying and pain-relieving effects of the bee therapy patch are further enhanced, and the drug absorption effect is enhanced. In the traditional Chinese medicine powder, the compatibility of multiple components such as radix aconiti, radix aconiti kusnezoffii, radix sileris, short-pedicel aconite root, rhizoma smilacis glabrae, loranthus parasiticus, rhizoma cibotii and the like is adopted, so that the dehumidifying and pain-relieving effects of the traditional Chinese medicine powder are enhanced, and further, the traditional Chinese medicine powder is matched with a plaster substrate, so that the dehumidifying and pain-relieving effects of the bee therapy patch are further enhanced.
In summary, the plaster matrix containing propolis, beeswax, bee dry powder and plum blossom bonesetting pill is adopted, and the plaster matrix and the traditional Chinese medicine powder are mutually matched, and are promoted by the medicine accelerant, so that the medicine effect absorption degree is improved, the application comfort level is enhanced, and the effects of dehumidifying, relieving pain, promoting blood circulation, removing blood stasis, clearing and activating the channels and collaterals of the bee therapy patch are improved.
Preferably, the components of the traditional Chinese medicine powder further comprise the following components in parts by weight:
2-2.5 parts of long pepper;
12-13 parts of rhizoma dioscoreae nipponicae;
8-9 parts of clematis root.
By adopting the technical scheme, after the long pepper, the dioscorea nipponica makino and the clematis root are added, the effects of dredging channels and collaterals, promoting blood circulation and the like are achieved, so that the effects of promoting blood circulation, relieving pain, clearing and activating channels and collaterals of the bee therapy patch are further enhanced by matching with bee components in the traditional Chinese medicine powder and the plaster matrix.
Preferably, the components of the traditional Chinese medicine powder further comprise the following components in parts by weight:
7.5-8.5 parts of acanthopanax bark;
20-22 parts of honeysuckle stem.
By adopting the technical scheme, the acanthopanax bark is the root and bark part of the acanthopanax senticosus, contains polysaccharide, is matched with the honeysuckle stem for use, and has better functions of nourishing liver and kidney, promoting blood circulation, reducing blood stasis and improving the functions of clearing and activating the channels and collaterals. When the bee therapeutic patch is added, the bee therapeutic patch is matched with beeswax, bee dry powder and Chinese medicinal powder, so that the blood circulation promoting and pain relieving effects of the bee therapeutic patch are further enhanced. In addition, the honeysuckle stem also has a certain effect of inhibiting allergy, so that the stimulation of the bee therapy patch to the skin is reduced, and the comfort level of the patch is improved.
Preferably, the traditional Chinese medicine powder further comprises the following components in parts by weight:
0.4-0.6 part of nux vomica;
7.5-8.5 parts of rhizoma sparganii;
7.5-8.5 parts of curcuma zedoary;
8-9 parts of Chinese medicinal powder of Burseraceae.
By adopting the technical scheme, the nux vomica is dry mature seeds of nux vomica of nux of marchanaceae, the rhizoma sparganii is tuber of scirpus yagara of cyperaceae, and the curcuma zedoary is a perennial herb of curcuma of zingiberaceae, and is a natural plant; when the substances are mutually matched, the Chinese medicinal composition is helpful to promote blood breaking, qi circulation promoting, blood stasis removing and blood circulation activating, so that the Chinese medicinal composition is combined with other Chinese medicinal powder and bee components to further enhance the degree of activating blood circulation, removing blood stasis, clearing and activating the channels and collaterals, and improve the dehumidifying and pain-relieving effects of the bee therapy patch.
Preferably, the Chinese medicinal powder of the olive family consists of the following components in parts by weight:
4-4.5 parts of prepared frankincense;
4-4.5 parts of prepared myrrh.
By adopting the technical scheme, the Chinese medicinal powder of the olive family has better functions of promoting blood circulation, relieving pain, reducing swelling and promoting granulation, and the preferred prepared frankincense and prepared myrrh are softer and can be used together with more medicaments; the two are used together to relieve pain, activate blood, and dredge meridian passage while removing blood stasis and dampness.
Preferably, the drug accelerator consists of the following components in parts by weight:
40-60 parts of camphor;
40-60 parts of borneol.
By adopting the technical scheme, the specific proportion of the camphor and the borneol is optimized, so that the camphor and the borneol are better matched, the absorption of the effective components of the bee therapy patch by a human body is further promoted, and the effects of dehumidifying, relieving pain, promoting blood circulation, removing blood stasis and clearing and activating the channels and collaterals of the bee therapy patch are improved.
In a second aspect, the application provides a preparation method of a bee therapy patch, which adopts the following technical scheme:
a preparation method of a bee therapy patch comprises the following preparation steps:
s1, uniformly mixing the Plumbum preparatium and the tung oil, decocting at 180-215 ℃ for 50-70min, filtering to obtain a primary plaster matrix;
s2, boiling the primary plaster substrate at the temperature of 270-290 ℃, adding amber powder, beeswax and propolis for mixing when water drops into beads, cooling to 90-100 ℃ after mixing uniformly, adding bee dry powder, and mixing uniformly to obtain the plaster substrate;
s3, removing fire toxin from the plaster matrix, heating the plaster matrix, keeping the temperature at 90-125 ℃, adding the traditional Chinese medicine powder and the medicine absorbent, mixing uniformly to obtain a first mixture;
s4, pressing, cutting and packaging the first mixture to obtain the bee therapy paste finished product.
By adopting the technical scheme, the tung oil and the plum blossom are decocted in the endosseous minium to obtain the juice, the primary plaster substrate is obtained, the decoction is continued, when the consistency of dripping water into beads is achieved, the beeswax and the propolis are added for mixing and decocting, the uniform mixing effect among the components of the plaster substrate is further improved, the dehumidification and pain relieving effects are improved, the proper viscosity is ensured, and the use comfort level is improved; finally, the bee dry powder is added after cooling, so that the nutrient components of the bee dry powder are prevented from being damaged due to overhigh temperature, and the effect of the plaster matrix is greatly reserved; after the action of removing fire toxin, the prepared bee therapy paste is reduced and directly pasted on the surface of the skin, the stimulation to the skin is reduced, and the use comfort is further improved. Finally, adding the traditional Chinese medicine powder, the drug absorbent and the like for mixing together, and better mixing all the components with the propolis, the beeswax and the bee dry powder uniformly; and then processing and packaging to obtain the bee therapy patch finished product with the effects of dehumidifying, relieving pain, promoting blood circulation, removing blood stasis, clearing and activating the channels and collaterals.
Preferably, in the step S1, the decocting temperature is 190-.
By adopting the technical scheme, the decoction temperature in the step S1 is preferably selected, the medicine effect quality is easily influenced by overhigh temperature, the decoction of the plum blossom Adonis pill and the tung oil is easily incomplete due to overlow temperature, the loss is more, the decoction efficiency is effectively improved, the medicine effects of the components are kept while the decoction efficiency is effectively improved by controlling the temperature within the range, and the cold dampness dispelling and pain relieving effects of the bee patch are further enhanced.
Preferably, in the step S3, the specific steps of removing fire toxin include soaking the plaster matrix in water for 6-8 days, changing water once a day, removing water and heating.
By adopting the technical scheme, the plaster matrix is soaked, so that the irritation of the plaster matrix to the skin is weakened, the irritation degree of the bee therapy patch to the skin in the use process is further reduced, and the application comfort level of bee therapy is improved.
Preferably, in the step S3, the temperature is maintained at 100-120 ℃.
By adopting the technical scheme, the decoction is not thorough easily caused by too low temperature, and the drug effect is poor; if the temperature is too high, the effect of losing the drug effect of part of the medicament at high temperature is easily caused, the viscosity is easily caused to be higher, and the use feeling is poorer; by controlling the temperature of the final preparation steps of the bee therapy patch, the efficacy of the traditional Chinese medicine powder and the plaster matrix is effectively exerted, and the dampness eliminating and pain relieving effects of the bee therapy patch are further improved.
In summary, the present application has the following beneficial effects:
1. in the application, by adopting the plaster matrix containing propolis, beeswax, bee dry powder and plum blossom bonesetting powder and mutually matching with the traditional Chinese medicine powder, the medicament accelerator promotes the absorption of a human body, prolongs the medicament absorption degree, enhances the application comfort level of the bee therapy patch and improves the dehumidifying and pain-relieving effects of the bee therapy patch.
2. In the application, the Chinese medicinal powder such as long pepper, yam, acanthopanax bark, Chinese medicinal powder of olivaceae and the like are added, and the Chinese medicinal powder and the propolis, the bee dry powder and the like in the plaster matrix act together, so that the degree of activating blood circulation, removing blood stasis, clearing and activating the channels and collaterals is further enhanced, and the effect of dehumidifying and stopping the bee therapy patch is improved.
3. According to the preparation method, the adding sequence of the components is controlled, and the comfort level of the patient is improved while the effect of eliminating dampness and relieving pain of the bee therapy patch is improved by methods of removing fire toxin, controlling the temperature of each step and the like.
Detailed Description
The present application is described in further detail below.
Examples
Example 1A bee therapy patch, comprising the specific components and weights shown in Table 1, is prepared by the following steps:
s1, uniformly mixing the Plumbum preparatium and oleum Verniciae fordii, decocting at 180 deg.C for 70min, and filtering to obtain a primary plaster matrix;
s2, decocting the primary plaster substrate at 270 ℃, adding amber powder, beeswax and propolis when water drops form beads (namely the oil drops form beads but do not disperse), mixing uniformly, cooling to 90 ℃, adding dry bee powder, and mixing uniformly to obtain the plaster substrate;
s3, removing fire toxin from the plaster matrix, wherein the specific steps of removing fire toxin are as follows: soaking plaster matrix in water for 5 days, removing water, heating plaster matrix, maintaining temperature at 90 deg.C, adding Chinese medicinal powder and medicinal absorbent, mixing to obtain first mixture;
s4, pressing, cutting and packaging the first mixture to obtain the bee therapy paste finished product.
Embodiment 2 is a patch for bee therapy, which is different from embodiment 1 in that the decocting temperature in step S1 is 215 ℃, the decocting time is 50min, the decocting temperature in step S2 is 290 ℃, and the temperature is reduced to 100 ℃; the temperature was maintained at 125 ℃ in step S3, and the specific components and weights included are shown in table 1.
Examples 3-8 a patch for bee therapy, which is different from example 1 in the specific components and weight, and comprises the specific components and weight shown in table 1.
TABLE 1 specific Components and weights in examples 1-8
Figure BDA0003433919310000051
Figure BDA0003433919310000061
Examples 9 to 10 a patch for bee therapy, which is different from example 8 in the specific components and weights included, the specific components and weights are shown in table 2.
Examples 11 to 12 a bee patch, which is different from example 10 in the specific components and weight of the powder of a Chinese medicinal material of the family Burseraceae, is shown in Table 2.
Examples 13 to 14 bee patch, which is different from example 12 in the specific components and weight of the drug enhancer, are included as shown in Table 2.
Example 15A patch for bee therapy, which is different from example 14 in that, in step S1, the decoction temperature is 190 ℃.
Example 16A patch for bee therapy, which is different from example 15 in that, in step S1, the decoction temperature is 210 ℃.
Example 17A patch for bee therapy, which is different from example 16 in that in step S3, the patch matrix is soaked in water for 6 days, and the water is changed once a day, and then the water is removed.
Example 18A patch for bee therapy, which is different from example 16 in that in step S3, the patch matrix is soaked in water for 8 days, and the water is changed once a day, and then the water is removed.
Example 19A patch for bee therapy, which is different from the patch of example 18 in that the temperature of the liquid medicine is 100 ℃ in step S3.
Example 20A patch for bee therapy, which is different from example 18 in that the temperature of the liquid medicine is 120 ℃ in step S3.
Examples 21 to 22A patch for bee therapy, which is different from example 20 in the point that each component and weight are different, and the specific components and weights thereof are included as shown in Table 2.
TABLE 2 specific compositions and weights for examples 9-14, examples 21-22
Figure BDA0003433919310000071
Figure BDA0003433919310000081
Comparative example
Comparative example 1 a bee patch, different from example 1, containing no beeswax.
Comparative example 2 a bee patch, which is different from example 1 in that propolis is not contained.
Comparative example 3 a bee patch, which is different from example 1 in that it does not contain dried bee powder.
Comparative example 4 a bee patch, which is different from example 1 in that propolis and bee powder are not contained.
Comparative example 5 a bee patch, which is different from example 1 in that it does not contain propolis, beeswax and bee powder.
Comparative example 6 a bee treatment patch, which is different from example 1 in that it does not contain the plum blossom pellet for bone setting.
Comparative example 7 a bee therapy patch, which is different from example 1 in that it does not contain Plumbum preparatium, propolis, beeswax and bee powder.
Comparative example 8 a bee treatment patch, which is different from example 1 in that it does not contain pubescent angelica root, ledebouriella root and loranthus parasiticus.
Comparative example 9 a bee therapy patch, which is different from example 1 in that the patch base does not contain beeswax, propolis and bee powder; the Chinese medicinal powder does not contain radix Angelicae Pubescentis, radix Saposhnikoviae, and herba Taxilli.
Comparative example 10A traditional Chinese medicine patch, comprising the following preparation steps:
s1: weighing 2kg of ephedra, 2kg of red paeony root, 4kg of rhizoma anemarrhenae, 3kg of ginger, 3kg of cassia twig, 5kg of honey-fried licorice root, 5kg of salvia miltiorrhiza, 6kg of Chinese starjasmine stem, 10kg of spreading hedyotis herb, 4kg of weeping forsythia, 2kg of divaricate saposhnikovia root, 6kg of notopterygium root, 8kg of longclaw leaf, 2kg of realgar, 5kg of drynaria rhizome, 3kg of Chinese starjasmine stem, 5kg of suberect spatholobus stem and 8kg of tall gastrodia tuber according to the weight ratio, and mixing for later use;
s2: putting the mixed medicinal materials weighed in the step S1 into a pulverizer to be pulverized into powder, and sieving the powder with a 200-mesh sieve;
s3: adding 5% of Chinese liquor into the sieved medicinal powder, uniformly mixing, sealing and standing for 48 hours;
s4: adding 12kg of beeswax into the mixture obtained in the step S3, repeatedly rolling and fully mixing the beeswax and the mixture evenly;
s5: placing the shaped plaster in the middle of the matrix adhesive, covering the adhesive film, and placing the important plaster between the adhesive film and the matrix adhesive to obtain the Chinese medicinal plaster for treating rheumatic osteodynia.
Detection method
Experiment I, the bee therapy patch is applied to external safety experiment samples: the patches of examples 1-22 and comparative examples 1-10 were used as experimental samples; the patches of examples 1-22 were named as experimental samples 1-22, respectively, and the patches of comparative examples 1-10 were named as comparative samples 1-10, respectively; each bee therapy paste is 15g in weight and 50 x 60mm in size; there were 3 samples for each experiment.
Selecting 96 healthy and non-injured guinea pigs (each half of male and female), and dividing into 32 groups of 3 animals; the two sides of the back of the guinea pig are unhaired by about 34cm 24h before the test 2 (approximately 10% of the body surface area).
The experimental method comprises the following steps: attaching experimental samples to the unhairing positions of the experimental objects, wherein the front 22 groups are respectively attached with the experimental samples 1-22, and the rear 10 groups are respectively correspondingly attached with the comparison samples 1-10; after 72h of mounting, subject 7d was observed continuously.
The experimental results show that the subjects using the experimental samples 1 to 22 and the comparative samples 1 to 10 have no abnormal reaction, and no abnormal phenomena such as weight, skin, hair color, eye mucosa, stool, respiration, limb movement, behavior and the like are found; therefore, the bee therapy patch is externally applied to the guinea pig, has no acute toxic reaction and higher safety.
Second experiment for sensory evaluation of effects experimental samples the bee patches of examples 1-22 and comparative examples 1-10 were used as experimental samples; the patches of examples 1-22 were named as experimental samples 1-22, respectively, and the patches of comparative examples 1-10 were named as comparative samples 1-10, respectively; each patch weighs 15g and has a size of 75 × 160 mm.
Selecting 320 outpatients (half of men and women), wherein the age is between 40 and 60 years old, and the lumbar parts of the patients all have symptoms such as pain, swelling, blood stasis and the like; patients were divided into 32 groups of 10 people each.
The experimental method comprises the following steps that corresponding experimental samples are respectively applied to the lumbar vertebra parts of an experimental object, and are replaced once every 3 days for 9 times, and then the experiment is finished; the experimental effect is evaluated by the experimental subjects respectively, and the evaluation criteria are as follows:
dehumidification and pain relief: 1-10 points, the more obvious the dehumidification and pain-relieving effect is, the higher the point is; the weaker the dehumidification analgesic effect, the lower the score.
The effects of promoting blood circulation to remove blood stasis/dredging channels and activating collaterals: 1-10 points, the more obvious the effects of promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals are, the higher the points are; the weaker the effect of activating blood circulation to dissipate blood stasis and clearing and activating the channels and collaterals, the lower the score.
Comfort level of application: 1-10 points, wherein the higher the score is if the application comfort level is higher in the using process, and the lower the score is if the application comfort level is poorer;
the cure rate is as follows: if the pain symptom disappears, the activity is normal, and no abnormal phenomenon exists, the pain symptom is treated as being cured, and the cure rate of each experimental sample is calculated by the number of cured people/group of people multiplied by 100%.
Scoring the members of each group of experimental objects, and taking the average value of each score given by each group of members as the final evaluation value of the evaluation; for example, 10 subjects of the test sample 1 were used, and the items were scored after use, and the average value of the items was calculated from the score of the subject for a specific item, for example, dehumidification analgesia, and used as the evaluation value of dehumidification analgesia of the final test sample 1.
Sensory evaluation test results of the test samples 1 to 22 and the comparative samples 1 to 10 were obtained by the above test methods, respectively.
The experimental results are as follows: sensory evaluation test results of the test samples 1 to 22 and the comparative samples 1 to 10 are shown in Table 3.
TABLE 3 results of the experiments of the experimental samples 1 to 22 and the comparative samples 1 to 10
Figure BDA0003433919310000101
As can be seen from the experimental data in Table 4, the test samples 1-22 have an evaluation of 8.1-9.7 for pain and dampness removal, 8.0-9.3 for blood circulation promotion, blood stasis removal, and meridian passage clearing, 8.3-9.4 for comfort level of application, and 81.9-83.9% for cure rate; the comparative samples 1 to 10 had an evaluation of 5.1 to 7.6 for dehumidification and analgesia, an evaluation of 5.4 to 7.7 for promoting blood circulation to remove blood stasis, and clearing and activating the channels and collaterals, an evaluation of 6.8 to 8.2 for the comfort of application, and a cure rate of 59.6 to 78.9%. Therefore, compared with the comparative samples 1 to 10, the experimental samples 1 to 22 have better effects of dehumidifying, relieving pain, promoting blood circulation and removing blood stasis, higher cure rate, more comfortable use and better application property.
Comparing the experimental sample 1 with the comparative samples 1-5, it can be seen that the bee therapy patch has better effects of dehumidifying, relieving pain, promoting blood circulation, removing blood stasis, and dredging meridian passage after the propolis, the beeswax and the bee dry powder are added; the bee therapy paste has better use effect than that of independently using each component and combining the three components. Comparing the experimental sample 1 with the comparative samples 5-6, it can be seen that the bee therapy patch has enhanced effects of removing dampness and relieving pain, promoting blood circulation by removing blood stasis, and clearing and activating the channels and collaterals after adding the plum blossom pellet for bone setting and the propolis, the beeswax, and the bee dry powder, which indicates that the plum blossom pellet for bone setting and the three bee products are combined to contribute to enhancing the use efficacy of the bee therapy patch. Comparing the experimental sample 1, the comparative sample 5 and the comparative samples 8-9, it can be seen that after the traditional Chinese medicines such as radix angelicae pubescentis, radix sileris and the like and three bee products are added, the effects of clearing and activating the channels and collaterals, and dehumidifying and relieving pain are further enhanced, which shows that after the traditional Chinese medicine powder is combined with the beewax, the propolis and the bee dry powder, the use effect of the bee therapy patch is further improved, and the application comfort level is improved.
Comparing the experimental sample 1 and the experimental samples 5-6, the addition of the long pepper, the yam rhizome and the clematis root is beneficial to clearing and activating the channels and collaterals better, so that the effects of activating blood and relieving pain of the bee therapy patch are further enhanced. Comparing the experimental samples 6-8, it can be seen that the bee therapy patch has the effects of improving the blood circulation promoting effect, inhibiting skin allergy and improving the comfort level of application after the cortex acanthopanacis and the honeysuckle stem are added. Comparing with experimental sample 8-10, it can be seen that the addition of semen Strychni, rhizoma Sparganii, Curcumae rhizoma, and Chinese medicinal powder of Burseraceae further enhances the effects of eliminating dampness and relieving pain of the patch. Comparing the experimental samples 10-12, it is known that the effects of promoting blood circulation and relieving pain are further enhanced while the comfort of application is improved after the frankincense and myrrh are preferably prepared as the Chinese medicinal powder of the olive family.
Comparing the experimental samples 12-14, it can be seen that the preferred weight ratios of the components in the pharmaceutical enhancer further promote the absorption of the human body to the traditional Chinese medicine powder, beeswax, propolis and bee dry powder of the patch, thereby improving the dehumidifying and pain-relieving effects of the patch.
Comparing the experimental samples 14-16, it can be seen that the decoction temperature during the preparation of the primary plaster matrix is preferably selected, so that the decoction efficiency is improved while the drug effect is improved, and the blood circulation promoting and pain relieving effects of the bee patch are further improved.
As shown by comparing the experimental samples 16-18, the step of removing the fire toxin is beneficial to reducing the irritation to the skin in the use process of the bee therapy patch, and the use comfort is further improved. Comparing with the experimental samples 18-20, the temperature of the liquid medicine is controlled, so that the loss of the medicine effect is further reduced, and the comfort level of application is improved.
Comparing the experimental sample 1 with the experimental samples 21-22, the specific components of the bee therapy patch are preferred, and the preparation steps are preferred, so that the bee therapy patch is endowed with better dehumidification, pain relief, meridian passage dredging and application comfort.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims (10)

1. A bee therapy patch with the effects of removing dampness, relieving pain, promoting blood circulation, removing blood stasis and clearing and activating the channels and collaterals is characterized in that the bee therapy patch is prepared from three raw materials, namely plaster matrix, traditional Chinese medicine powder and medicine promoter, according to the weight ratio of (4-8.8) to (0.7-1.9) to 1:
the plaster matrix is prepared from the following components in parts by weight:
200 portions and 300 portions of tung oil;
30-50 parts of plum blossom Adonis amurensis;
300 portions of amber powder;
10-20 parts of beeswax;
5-10 parts of propolis;
5-10 parts of bee dry powder;
the traditional Chinese medicine powder comprises the following components in parts by weight:
30-45 parts of glabrous greenbrier rhizome;
2-2.5 parts of radix aconiti;
2-2.5 parts of kusnezoff monkshood root;
3-3.5 parts of cinnamon;
6.5-7 parts of short-pedicel aconite root;
6-7 parts of radix angelicae pubescentis;
7.5-8.5 parts of divaricate saposhnikovia root;
12-13 parts of parasitic loranthus;
3-4 parts of coptis chinensis;
7.5-8.5 parts of phellodendron;
9-10 parts of rhizoma cibotii;
the weight portion of the drug accelerator is 80-120 parts, and the drug accelerator is at least one of camphor and borneol.
2. A bee therapy patch with the effects of removing dampness, relieving pain, promoting blood circulation, removing blood stasis and clearing and activating the channels and collaterals is characterized in that the bee therapy patch is prepared from three raw materials, namely plaster matrix, traditional Chinese medicine powder and medicine promoter, according to the weight ratio of (4-8.8) to (0.7-1.9) to 1:
the plaster matrix is prepared from the following components in parts by weight:
200 portions and 300 portions of tung oil;
30-50 parts of plum blossom Adonis amurensis;
300 portions of amber powder;
10-20 parts of beeswax;
5-10 parts of propolis;
5-10 parts of bee dry powder;
the traditional Chinese medicine powder comprises the following components in parts by weight:
30-45 parts of glabrous greenbrier rhizome;
2-2.5 parts of radix aconiti;
2-2.5 parts of kusnezoff monkshood root;
3-3.5 parts of cinnamon;
6.5-7 parts of short-pedicel aconite root;
6-7 parts of radix angelicae pubescentis;
7.5-8.5 parts of divaricate saposhnikovia root;
12-13 parts of parasitic loranthus;
3-4 parts of coptis chinensis;
7.5-8.5 parts of phellodendron;
9-10 parts of rhizoma cibotii;
2-2.5 parts of long pepper;
12-13 parts of Ningpo Yam rhizome;
8-9 parts of clematis root;
the weight portion of the drug accelerator is 80-120 parts, and the drug accelerator is at least one of camphor and borneol.
3. A bee therapy patch with the effects of removing dampness, relieving pain, promoting blood circulation, removing blood stasis and clearing and activating the channels and collaterals is characterized in that the bee therapy patch is prepared from three raw materials, namely plaster matrix, traditional Chinese medicine powder and medicine promoter, according to the weight ratio of (4-8.8) to (0.7-1.9) to 1:
the plaster matrix is prepared from the following components in parts by weight:
200 portions and 300 portions of tung oil;
30-50 parts of plum blossom Adonis amurensis pill;
300 portions of amber powder;
10-20 parts of beeswax;
5-10 parts of propolis;
5-10 parts of bee dry powder;
the traditional Chinese medicine powder comprises the following components in parts by weight:
30-45 parts of glabrous greenbrier rhizome;
2-2.5 parts of radix aconiti;
2-2.5 parts of kusnezoff monkshood root;
3-3.5 parts of cinnamon;
6.5-7 parts of short-pedicel aconite root;
6-7 parts of radix angelicae pubescentis;
7.5-8.5 parts of divaricate saposhnikovia root;
12-13 parts of parasitic loranthus;
3-4 parts of coptis chinensis;
7.5-8.5 parts of phellodendron;
9-10 parts of rhizoma cibotii;
7.5-8.5 parts of acanthopanax bark;
20-22 parts of honeysuckle stem;
the weight portion of the drug accelerator is 80-120 parts, and the drug accelerator is at least one of camphor and borneol.
4. A bee therapy plaster with the functions of removing dampness and relieving pain, promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals is characterized in that the bee therapy plaster is prepared from three raw materials of plaster matrix, traditional Chinese medicine powder and medicine promoter according to the weight ratio of (4-8.8) to (0.7-1.9) to 1:
the plaster matrix is prepared from the following components in parts by weight:
200 portions and 300 portions of tung oil;
30-50 parts of plum blossom Adonis amurensis;
300 portions of amber powder;
10-20 parts of beeswax;
5-10 parts of propolis;
5-10 parts of bee dry powder;
the traditional Chinese medicine powder comprises the following components in parts by weight:
30-45 parts of glabrous greenbrier rhizome;
2-2.5 parts of radix aconiti;
2-2.5 parts of kusnezoff monkshood root;
3-3.5 parts of cinnamon;
6.5-7 parts of short-pedicel aconite root;
6-7 parts of radix angelicae pubescentis;
7.5-8.5 parts of divaricate saposhnikovia root;
12-13 parts of parasitic loranthus;
3-4 parts of coptis chinensis;
7.5-8.5 parts of phellodendron;
9-10 parts of rhizoma cibotii;
0.4-0.6 part of nux vomica;
7.5-8.5 parts of rhizoma sparganii;
7.5-8.5 parts of curcuma zedoary;
8-9 parts of Chinese medicinal powder of Burseraceae family;
the weight portion of the drug accelerator is 80-120 parts, and the drug accelerator is at least one of camphor and borneol.
5. The bee therapy patch with the effects of dehumidifying, relieving pain, promoting blood circulation to remove blood stasis and clearing and activating the channels and collaterals as claimed in claim 4, wherein the Chinese medicinal powder of the family Burseraceae comprises the following components in parts by weight:
4-4.5 parts of prepared frankincense;
4-4.5 parts of prepared myrrh.
6. The bee therapy patch with the effects of removing dampness, relieving pain, promoting blood circulation, removing blood stasis and clearing and activating the channels and collaterals as claimed in any one of claims 1-5, wherein the drug accelerator consists of the following components in parts by weight:
40-60 parts of camphor;
40-60 parts of borneol.
7. The preparation method of the bee therapy patch with the effects of removing dampness, relieving pain, promoting blood circulation, removing blood stasis and clearing and activating the channels and collaterals as claimed in any one of claims 1 to 6 is characterized by comprising the following preparation steps:
s1, uniformly mixing the Plumbum preparatium and tung oil, decocting at 215 ℃ for 50-70min at 180 ℃, and filtering to obtain a primary plaster matrix;
s2, boiling the primary plaster substrate at the temperature of 270-290 ℃, adding amber powder, beeswax and propolis for mixing when water drops into beads, cooling to 90-100 ℃ after mixing uniformly, adding bee dry powder, and mixing uniformly to obtain the plaster substrate;
s3, removing fire toxin from the plaster matrix, heating the plaster matrix, keeping the temperature at 90-125 ℃, adding the traditional Chinese medicine powder and the medicine absorbent, mixing uniformly to obtain a first mixture;
s4, pressing, cutting and packaging the first mixture to obtain the bee therapy paste finished product.
8. The method for preparing the bee therapy patch with the effects of removing dampness and relieving pain, promoting blood circulation and removing blood stasis, and clearing and activating the channels and collaterals as claimed in claim 7, wherein in the step S1, the decoction temperature is 190 ℃ and 210 ℃.
9. The method for preparing the bee-therapy patch with the effects of removing dampness, relieving pain, promoting blood circulation, removing blood stasis, and dredging meridian passage according to claim 7, wherein the specific steps of removing fire-toxin in step S3 are soaking the plaster substrate in water for 6-8 days, changing water once a day, removing water, and heating.
10. The method for preparing the bee therapy patch with the effects of removing dampness and relieving pain, activating blood and dissolving stasis, and clearing and activating the channels and collaterals as claimed in claim 7, wherein in the step S3, the temperature is maintained at 100-120 ℃.
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Citations (3)

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Publication number Priority date Publication date Assignee Title
CN105343381A (en) * 2015-12-22 2016-02-24 青岛海之源智能技术有限公司 Plaster for treating tenosynovitis and preparation method of plaster
CN106110110A (en) * 2016-06-16 2016-11-16 单县郭村惠民诊所 Treatment hyperosteogeny, cervical spondylosis, lumbar spondylosis, arthritic plaster
CN109394890A (en) * 2018-12-14 2019-03-01 北京蜂珍科技开发有限公司 A kind of bee venom plaster for curing rheumatism

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105343381A (en) * 2015-12-22 2016-02-24 青岛海之源智能技术有限公司 Plaster for treating tenosynovitis and preparation method of plaster
CN106110110A (en) * 2016-06-16 2016-11-16 单县郭村惠民诊所 Treatment hyperosteogeny, cervical spondylosis, lumbar spondylosis, arthritic plaster
CN109394890A (en) * 2018-12-14 2019-03-01 北京蜂珍科技开发有限公司 A kind of bee venom plaster for curing rheumatism

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