CN110302269A - A kind of warming and activating meridian foot-soaking liquid - Google Patents
A kind of warming and activating meridian foot-soaking liquid Download PDFInfo
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Abstract
The invention belongs to health product technology field, especially a kind of warming and activating meridian foot-soaking liquid；It is prepared from the following raw materials by weight: 80-120 parts of wormwood stoste, 12-18 parts of Radix Astragali, 12-18 parts of Rhizoma Chuanxiong, 12-18 parts of Radix Angelicae Sinensis, 12-18 parts of evodia rutaecarpa, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 3-6 parts of the root of Chinese clematis, 8-12 parts of radix paeoniae rubra, 8-12 parts of ramulus cinnamomi；Preparation process are as follows: first crush Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, evodia rutaecarpa, Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis, radix paeoniae rubra, ramulus cinnamomi, mixing obtains traditional Chinese medicine powder；Then it adds water to cook to traditional Chinese medicine powder to boiling, is slowly added to ethyl alcohol after cooling while stirring, kept the temperature after adding, recycle ethyl alcohol, obtain Traditional Chinese drug mixture A；Traditional Chinese drug mixture A and wormwood stoste are mixed again, obtain Traditional Chinese drug mixture B；And compound bacteria fermentation is added in backward Traditional Chinese drug mixture B, it sterilizes, filtering obtains foot-soaking liquid.Foot-soaking liquid provided by the present invention has effects that temperature three-way meridian, qi and activate blood circulation, to because of cold-dampness, overstrain, channels and collaterals stasis blocking caused by station, long row, traumatic injury etc., pain, out of strength etc. have good curative effect long.
Description
Technical field
The invention belongs to health product technology field, especially a kind of warming and activating meridian foot-soaking liquid.
Background technique
Channels and collaterals are the general names of passages through which vital energy circulates and channels, are the networks based on hand, three yin of foot and three yang channels and conception vessel and governor vessel
Throughout an integrated system of whole body；Mean the channel of whole body QI-blood circulation.The inline vital organs of the human body of channels and collaterals, the outer cloth face seven apertures,
Four limbs bones of the body collectively links up in table, is upper and lower, inside and outside, each section of human body is connected into organically.The unimpeded then Whole Body of channels and collaterals is light
Pine, not general rule pain.Many expert, scholars sufficiently confirmed many cureless diseases or prolonged administration of drugs all and
Blockage of main and collateral channels has relationship, and the research of the active drug of dysmenorrhea and technology plays a significant role in human health-preserving and disease treatment.Mesh
Before, occur the active drug of many dysmenorrheas in the market, but it is used for that the aspect in terms of lavipeditum to be less or middle pharmacopoeia ingredient is more,
Do not distinguish which which ingredient plays the role of specifically, between each other collocation coordinate synergy position again where.Such as Shen
Please number be CN201810420783.7 a kind of thrombus dredging collateral drug of patent disclosure and preparation method thereof, using the coptis, radix scutellariae,
Liquid medicine is made in 90 kinds of traditional Chinese medicines such as Cortex Magnoliae Officinalis, the tuber of pinellia, madder, trigone, curcuma zedoary, rhizoma zingiberis, Radix Glycyrrhizae.
Footbath with traditional Chinese medicines has a long history in China, is the common health-care method of tradition.Lavipeditum have lessen fatigue,
Improve blood circulation, boosts metabolism, increases the effects of constitution.Its principle is: there are six main channels and collaterals on human foot,
The terminating point of i.e. three yang channels (bladder meridian, stomach meridian, gallbladder channel) and the starting point of three yin channel (the spleen channel, Liver Channel, kidney channel),.This six
Channels and collaterals and all zang-fu differentiations of whole body have substantial connection, therefore having foot is saying for the second heart of human body.Currently, about not
The Chinese medicine preparation research of warming and activating meridian in few footbath with traditional Chinese medicines, but be no lack of most of Chinese medicine preparations and lack clinical verification, also without in
The support of medical knowledge opinion, only simple drug is accumulative, and clinical efficacy waits to evaluate；Also there are many drug treatment effects poor, control
It is long to treat the period.Such as application No. is a kind of warming and activating meridians of the patent disclosure of CN201711330251.6, activating blood circulation and reducing swelling Chinese medicine
Foot bath preserving health healthy prescription, select safflower, folium artemisiae argyi, ramulus cinnamomi, rhizome of chuanxiong processed, lopseed, Qin's radix paeoniae rubra, radix saposhnikoviae, mountain plate, ramulus mori, Fructus Aurantii,
Each 10-15g of Cortex Eucommiae, Radix Glycyrrhizae, totally 12 taste Chinese medicinal composition；Juice is taken to use by water decoction.The prescription has warming and activating meridian, activating blood circulation and reducing swelling
The effect of, but there is no corresponding clinical verification in patent text, effect requires study.
Summary of the invention
In order to solve the above technical problems existing in the prior art, researcher of the present invention passes through the research and development of many years and faces
Bed experiment, with numerous Chinese medicines carry out screening study, and to medicinal material treatment process, specific dosage form preparation method also carry out it is different because
The impact analysis of element, proposes a kind of warming and activating meridian foot-soaking liquid, realizes particular by following technical scheme:
A kind of warming and activating meridian foot-soaking liquid, is made of raw material from the following weight: 80-120 parts of wormwood stoste, Radix Astragali 12-18
Part, 12-18 parts of Rhizoma Chuanxiong, 12-18 parts of Radix Angelicae Sinensis, 12-18 parts of evodia rutaecarpa, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 3-6 parts of the root of Chinese clematis, 8-12 parts of radix paeoniae rubra, osmanthus
8-12 parts of branch.
Preferably, the warming and activating meridian foot-soaking liquid, is made of raw material from the following weight: 100 parts of wormwood stoste, Radix Astragali 15
Part, 15 parts of Rhizoma Chuanxiong, 15 parts of Radix Angelicae Sinensis, 15 parts of evodia rutaecarpa, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of the root of Chinese clematis, 10 parts of radix paeoniae rubra, 10 parts of ramulus cinnamomi.
Preferably, the wormwood stoste is that 10 times of water soaked overnight is added after smashing wormwood to pieces, and centrifugation takes supernatant
To obtain the final product.
Preferably, the warming and activating meridian is bathed the preparation method of liquid, is included the following steps:
(1) each component is weighed by the above parts by weight, by Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, evodia rutaecarpa, Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis, radix paeoniae rubra, osmanthus
Branch crushes, mixing, obtains traditional Chinese medicine powder, spare；
(2) into traditional Chinese medicine powder plus 4 times or so of decocting is boiled after rising, then it is cooled to 50-60 DEG C, be slowly added to while stirring
2 times or so of ethyl alcohol after adding, keeps the temperature 15-20min, ethyl alcohol is recovered under reduced pressure, obtains Traditional Chinese drug mixture A；
(3) Traditional Chinese drug mixture A and wormwood stoste are mixed, obtains Traditional Chinese drug mixture B；And it is added in backward Traditional Chinese drug mixture B
Compound bacteria fermentation 3-4h, sterilizes, filtering, gained filtrate is foot-soaking liquid.
Preferably, the step (1), the partial size of traditional Chinese medicine powder are 100-120 mesh.
Preferably, the step (2), the addition speed of ethyl alcohol are 1ml/min.
Preferably, the compound bacteria is made of actinomyces, staphylococcus by the mass ratio mixing of 3-4:1.
Preferably, the additional amount of the compound bacteria is the 0.12-0.15% of Traditional Chinese drug mixture B mass.
Preferably, the temperature when fermentation is 25-28 DEG C.
The present invention is used using wormwood, evodia rutaecarpa, the root of Chinese clematis, ramulus cinnamomi, radix paeoniae rubra, Rhizoma Chuanxiong, Radix Angelicae Sinensis collocation, is removed with cold dispelling
Wet, warming channel and activating blood circulation removes obstruction in channels to relieve pain, the regulation of qi and blood, improves sanguimotor function effect；Radix Astragali, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae collocation use, and have
The benefits of nourishing qi and blood qi-restoratives.All medicines share, play altogether it is warming channel and expelling cold, remove obstruction in channels to relieve pain, the function of nourishing qi and blood.
The invention of this hair is extracted using the mode centering liquid medicine decoction liquor for being slowly added to ethyl alcohol during the preparation process, this
The mode for being slowly added to ethyl alcohol changes the concentration of alcohol in extraction process constantly, can increase each effective constituents in Chinese medicine
Dissolution rate；Selected human skin reside microorganism to Traditional Chinese drug mixture set out row fermentation, improve Chinese medicine in effectively at
While point dissolution rate, the part macromolecular substances in Traditional Chinese drug mixture can be converted to be easy to easily be absorbed by human skin it is small
Molecular substance promotes absorption of the human skin to Chinese medicine, enhances its drug effect.
Specific embodiment
It is limited below with reference to specific embodiment technical solution of the present invention is further, but claimed
Range is not only limited to made description.
Embodiment 1
Component: 80 parts of wormwood stoste, 12 parts of Radix Astragali, Rhizoma Chuanxiong 12,12 parts of Radix Angelicae Sinensis, 12 parts of evodia rutaecarpa, 8 parts of Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis 3
Part, 8 parts of radix paeoniae rubra, 8 parts of ramulus cinnamomi.
The wormwood stoste is that 10 times of water is added and impregnated liquid, is centrifuged, takes supernatant after smashing wormwood to pieces to obtain the final product.
Preparation method includes the following steps:
(1) each component is weighed by the above parts by weight, by Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, evodia rutaecarpa, Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis, radix paeoniae rubra, osmanthus
Branch is crushed to 100-120 mesh, mixes, and obtains traditional Chinese medicine powder, spare；
(2) after adding 4 times or so of decocting to boil and rise to traditional Chinese medicine powder, then it is cooled to 50-60 DEG C, is slowly added to 2 while stirring
Times or so ethyl alcohol, after adding, keep the temperature 15-20min, ethyl alcohol is recovered under reduced pressure, obtains Traditional Chinese drug mixture A；The wherein addition speed of ethyl alcohol
Degree is 1ml/min；
(3) Traditional Chinese drug mixture A and wormwood stoste are mixed, obtains Traditional Chinese drug mixture B；And it is added in backward Traditional Chinese drug mixture B
The compound bacteria of its quality 0.12-0.15% is fermented 3-4h at 25-28 DEG C, is sterilized, and filtering, gained filtrate is foot-soaking liquid.
The compound bacteria is made of actinomyces, staphylococcus by the mass ratio mixing of 3:1.
Embodiment 2
Component: 100 parts of wormwood stoste, 15 parts of Radix Astragali, 15 parts of Rhizoma Chuanxiong, 15 parts of Radix Angelicae Sinensis, 15 parts of evodia rutaecarpa, 10 parts of Rhizoma Atractylodis Macrocephalae, prestige
5 parts of medicine xiaolingxian, 10 parts of radix paeoniae rubra, 10 parts of ramulus cinnamomi.
The wormwood stoste is that 10 times of water soaked overnight is added after smashing wormwood to pieces, and centrifugation takes supernatant to obtain the final product.
Preparation method includes the following steps:
(1) each component is weighed by the above parts by weight, by Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, evodia rutaecarpa, Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis, radix paeoniae rubra, osmanthus
Branch is crushed to 100-120 mesh, mixes, and obtains traditional Chinese medicine powder, spare；
(2) after adding 4 times or so of decocting to boil and rise to traditional Chinese medicine powder, then it is cooled to 50-60 DEG C, is slowly added to 2 while stirring
Times or so ethyl alcohol, after adding, keep the temperature 15-20min, ethyl alcohol is recovered under reduced pressure, obtains Traditional Chinese drug mixture A；The wherein addition speed of ethyl alcohol
Degree is 1ml/min；
(3) Traditional Chinese drug mixture A and wormwood stoste are mixed, obtains Traditional Chinese drug mixture B；And it is added in backward Traditional Chinese drug mixture B
The compound bacteria of its quality 0.12-0.15% is fermented 3-4h at 25-28 DEG C, is sterilized, and filtering, gained filtrate is foot-soaking liquid.
The compound bacteria is made of actinomyces, staphylococcus by the mass ratio mixing of 3:1.
Embodiment 3
Component: 120 parts of wormwood stoste, 18 parts of Radix Astragali, 18 parts of Rhizoma Chuanxiong, 18 parts of Radix Angelicae Sinensis, 18 parts of evodia rutaecarpa, 12 parts of Rhizoma Atractylodis Macrocephalae, prestige
6 parts of medicine xiaolingxian, 12 parts of radix paeoniae rubra, 12 parts of ramulus cinnamomi.
The wormwood stoste is that 10 times of water soaked overnight is added after smashing wormwood to pieces, and centrifugation takes supernatant to obtain the final product.
Preparation method includes the following steps:
(1) each component is weighed by the above parts by weight, by Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, evodia rutaecarpa, Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis, radix paeoniae rubra, osmanthus
Branch is crushed to 100-120 mesh, mixes, and obtains traditional Chinese medicine powder, spare；
(2) after adding 4 times or so of decocting to boil and rise to traditional Chinese medicine powder, then it is cooled to 50-60 DEG C, is slowly added to 2 while stirring
Times or so ethyl alcohol, after adding, keep the temperature 15-20min, ethyl alcohol is recovered under reduced pressure, obtains Traditional Chinese drug mixture A；The wherein addition speed of ethyl alcohol
Degree is 1ml/min；
(3) Traditional Chinese drug mixture A and wormwood stoste are mixed, obtains Traditional Chinese drug mixture B；And it is added in backward Traditional Chinese drug mixture B
The compound bacteria of its quality 0.12-0.15% is fermented 3-4h at 25-28 DEG C, is sterilized, and filtering, gained filtrate is foot-soaking liquid.
The compound bacteria is made of actinomyces, staphylococcus by the mass ratio mixing of 4:1.
1 low dose group of comparative example
Comparative example 1 the difference from embodiment 1 is that component is different, be 75 parts of wormwood stoste, 10 parts of Radix Astragali, Rhizoma Chuanxiong 10, when
Return 10 parts, 10 parts of evodia rutaecarpa, 6 parts of Rhizoma Atractylodis Macrocephalae, 1 part of the root of Chinese clematis, 6 parts of radix paeoniae rubra, 6 parts of ramulus cinnamomi；Remaining process is identical.
2 high dose group of comparative example
Comparative example 2 is that component is different from the difference of embodiment 3, be 125 parts of wormwood stoste, 20 parts of Radix Astragali, 20 parts of Rhizoma Chuanxiong,
20 parts of Radix Angelicae Sinensis, 20 parts of evodia rutaecarpa, 15 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of the root of Chinese clematis, 15 parts of radix paeoniae rubra, 15 parts of ramulus cinnamomi；Remaining process is identical.
Comparative example 3
Comparative example 3 is that the compound bacteria being added in preparation method is different from the difference of embodiment 3, and what comparative example 3 was added answers
Combined bacteria only has actinomyces, remaining process is identical.
Comparative example 4
Comparative example 4 is that the compound bacteria being added in preparation method is different from the difference of embodiment 3, and what comparative example 4 was added answers
Combined bacteria only has staphylococcus；Remaining process is identical.
Comparative example 5
The difference of comparative example 5 and embodiment 3 is that compound bacteria is not added in preparation process, remaining is identical.
Comparative example 6
Comparative example 6 is during preparing hair that the adding manner of ethyl alcohol is different from the difference of embodiment 3, and ethyl alcohol is disposable
Addition finishes, remaining process is identical.
Clinical and experimental study:
Test method: pain patients caused by foot joint inflammation, dysmenorrhea are chosen and have carried out clinical observation experiment, patient data is such as
Shown in table 1.Foot joint inflammation patient, dysmenorrhea patient are randomly divided into experimental group and control group respectively.Experimental group is divided into 10 groups, respectively
Using the foot-soaking liquid for implementing 1-4 and comparative example 1-6 preparation for steeping foot, steeps foot method: foot-soaking liquid and warm water are pressed to the weight of 1:10
Amount steeps primary, each 40min or so, 15 days as a treatment course than mixing sooner or later daily.Foot joint inflammation patient does 2 treatments
Journey, dysmenorrhea do 4 courses for the treatment of.Control group (foot joint inflammation patient) takes orally Voltaren (Novartis Pharma AG's production)
25mg, 3 times a day, the course for the treatment of are same as above；Control group (dysmenorrhea patient) dissipates treatment using dysmenorrhea, and dysmenorrhea is dissipated by 6 grams of three cortex cinnamomi, radix notoginseng
3 grams, 30 grams of Shixiao San compositions, usage: medicine-feeding grinds to the powder altogether, takes daily 3 grams, and point early, evening is secondary to gulp down ga, premenstrual ten days moons beginning
Clothes, even served 13 days as a treatment course, take 2 menstrual cycles.
Patient clinical diagnoses is according to referring to " modern Chinese medicine clinical criteria ", and efficacy determination is referring to " disease of tcm is examined
Disconnected criterion of therapeutical effect " determine.
1 patient data of table
| Number of cases | Age | Male to female ratio | The course of disease | |
| Foot joint inflammation patient | 120 | 40-70 years old | 72:48 | 16-12 months |
| Dysmenorrhea patient | 120 | 18-30 years old | —— | 4-12 months |
2 foot joint inflammation patient's curative effect of table
| Group | Number of cases | Recovery from illness | Effectively | In vain | It is efficient |
| Embodiment 1 | 10 | 2 | 7 | 1 | 90% |
| Embodiment 2 | 10 | 4 | 6 | 0 | 100% |
| Embodiment 3 | 10 | 3 | 6 | 1 | 90% |
| Embodiment 4 | 10 | 2 | 8 | 0 | 100% |
| Embodiment summation | 40 | 11 | 27 | 2 | 95% |
| Comparative example 1 | 10 | 0 | 4 | 6 | 40% |
| Comparative example 2 | 10 | 1 | 6 | 3 | 70% |
| Comparative example 3 | 10 | 1 | 7 | 2 | 80% |
| Comparative example 4 | 10 | 2 | 4 | 4 | 60% |
| Comparative example 5 | 10 | 0 | 4 | 6 | 40% |
| Comparative example 6 | 10 | 2 | 5 | 3 | 70% |
| Comparative example summation | 60 | 6 | 30 | 24 | 60% |
| Control group | 20 | 3 | 13 | 4 | 80% |
3 dysmenorrhea patient's curative effect of table
It is important to point out that, above embodiments and test example are only limitted to do further technical solution of the present invention herein
Elaboration and understanding, should not be understood as it is further to technical solution of the present invention limited, what those skilled in the art made
The innovation and creation of non-protruding essential characteristics and marked improvement still fall within protection category of the invention.
Claims (9)
1. a kind of warming and activating meridian foot-soaking liquid, which is characterized in that be made of raw material from the following weight: 80-120 parts of wormwood stoste,
12-18 parts of Radix Astragali, 12-18 parts of Rhizoma Chuanxiong, 12-18 parts of Radix Angelicae Sinensis, 12-18 parts of evodia rutaecarpa, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 3-6 parts of the root of Chinese clematis, radix paeoniae rubra
8-12 parts, 8-12 parts of ramulus cinnamomi.
2. warming and activating meridian foot-soaking liquid as described in claim 1, which is characterized in that be made of raw material from the following weight: wormwood
100 parts of stoste, 15 parts of Radix Astragali, 15 parts of Rhizoma Chuanxiong, 15 parts of Radix Angelicae Sinensis, 15 parts of evodia rutaecarpa, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of the root of Chinese clematis, 10 parts of radix paeoniae rubra,
10 parts of ramulus cinnamomi.
3. warming and activating meridian foot-soaking liquid as claimed in claim 1 or 2, which is characterized in that the wormwood stoste, is to smash wormwood to pieces
Afterwards, 10 times of water soaked overnight is added, centrifugation takes supernatant to obtain the final product.
4. the preparation method of warming and activating meridian foot-soaking liquid as claimed in claim 1 or 2, which comprises the steps of:
(1) each component is weighed by the above parts by weight, by Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, evodia rutaecarpa, Rhizoma Atractylodis Macrocephalae, the root of Chinese clematis, radix paeoniae rubra, ramulus cinnamomi powder
Broken, mixing obtains traditional Chinese medicine powder, spare；
(2) into traditional Chinese medicine powder plus 4 times or so of decocting is boiled after rising, then it is cooled to 50-60 DEG C, is slowly added to 2 times while stirring
The ethyl alcohol of left and right after adding, keeps the temperature 15-20min, ethyl alcohol is recovered under reduced pressure, obtains Traditional Chinese drug mixture A；
(3) Traditional Chinese drug mixture A and wormwood stoste are mixed, obtains Traditional Chinese drug mixture B；And it is added in backward Traditional Chinese drug mixture B multiple
Combined bacteria fermentation 3-4h, sterilizes, filtering, gained filtrate is foot-soaking liquid.
5. the preparation method of warming and activating meridian foot-soaking liquid as claimed in claim 4, which is characterized in that the step (1), traditional Chinese medicine powder
Partial size be 100-120 mesh.
6. the preparation method of warming and activating meridian foot-soaking liquid as claimed in claim 4, which is characterized in that the step (2), ethyl alcohol
Addition speed is 1ml/min.
7. the preparation method of warming and activating meridian foot-soaking liquid as claimed in claim 4, which is characterized in that the compound bacteria is by unwrapping wire
Bacterium, staphylococcus mix composition by the mass ratio of 3-4:1.
8. the preparation method of warming and activating meridian foot-soaking liquid as claimed in claim 4, which is characterized in that the additional amount of the compound bacteria
For the 0.12-0.15% of Traditional Chinese drug mixture B mass.
9. the preparation method of warming and activating meridian foot-soaking liquid as claimed in claim 4, which is characterized in that the temperature when fermentation is
25-28℃。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112057489A (en) * | 2020-09-21 | 2020-12-11 | 杜小涛 | Efficient concentration method of wormwood raw liquid obtained through fermentation processing |
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