CN114762719B - Traditional Chinese medicine composition for relaxing tendons and activating collaterals and preparation method thereof - Google Patents
Traditional Chinese medicine composition for relaxing tendons and activating collaterals and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for relaxing tendons and activating collaterals, which comprises the following raw materials in parts by weight: 15-26 parts of pseudo-ginseng, 20-35 parts of safflower, 30-50 parts of szechuan lovage rhizome, 15-30 parts of myrrh, 15-30 parts of zedoary turmeric, 30-50 parts of Chinese angelica, 1-15 parts of wintergreen oil, 1-8 parts of eucalyptus oil, 0.5-1.5 parts of clove oil, 1-6 parts of camphor, 1-3 parts of menthol, 1-5 parts of borneol, 3-10 parts of hydrogenated castor oil and 0.5-4 parts of penetrating agent; the invention quenches the active ingredients of the traditional Chinese medicine with high activity by a scientific and efficient extraction method, and adds a proper amount of chemical ingredients of non-traditional Chinese medicines, and the traditional Chinese medicine is compounded and synergistic with the traditional Chinese medicines, and is combined with long-acting in time, so that the traditional Chinese medicine can relieve pain, detumescence and remove blood stasis, and can realize long-acting deep penetration to gradually and radically cure.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compound preparations, in particular to a traditional Chinese medicine composition for relaxing tendons and activating collaterals and a preparation method thereof.
Background
The traditional Chinese medicine has the following steps: pain is not clear, and general pain is not clear. For modern people, there are three main causes of pain: firstly, due to lack of exercise, people sit for a long time for office work, blood circulation is easy to be blocked, and channels and collaterals are not blocked; secondly, due to obesity, gout and the like caused by improper diet, tissue fat is excessive, and various nodule injuries caused by fatty tumor stasis or gout nodules formed by joint tissue stasis sodium glutamate urate; thirdly, the typhoid bone diseases, joint strain, rheumatism and the like are caused by excessive labor, traumatic injury and the like.
The tissue is not general due to the reasons, so that swelling and pain can be caused, and even life is endangered due to the fact that free movement is not possible. In order to relieve the symptoms, the effective composition for relaxing tendons, activating collaterals, promoting blood circulation by removing blood stasis and dispelling nodes and dredging is required to be used for treating diseases and relieving pain.
The existing many tendon-relaxing and collateral-activating composition (liquid/oil/paste) technologies have the following problems: 1) The traditional Chinese medicine composition is not a traditional Chinese medicine composition, takes effect quickly, but takes effect only in time, cannot radically treat the disease, and has larger side effect and irritation; 2) The pure traditional Chinese medicine composition has slow effect and insufficient osmotic power; 3) The extraction method of pure traditional Chinese medicine combination seeds is different, and effective substances cannot be extracted effectively, so that the effect of the composition is limited.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention aims to provide a traditional Chinese medicine composition for relaxing tendons and activating collaterals and a preparation method thereof.
The invention provides a traditional Chinese medicine composition for relaxing tendons and activating collaterals, which comprises the following raw materials in parts by weight: 15-26 parts of pseudo-ginseng, 20-35 parts of safflower, 30-50 parts of szechuan lovage rhizome, 15-30 parts of myrrh, 15-30 parts of zedoary turmeric, 30-50 parts of Chinese angelica, 1-15 parts of wintergreen oil, 1-8 parts of eucalyptus oil, 0.5-1.5 parts of clove oil, 1-6 parts of camphor, 1-3 parts of menthol, 1-5 parts of borneol, 3-10 parts of hydrogenated castor oil and 0.5-4 parts of penetrating agent.
Optionally, the material comprises the following raw materials in parts by weight: 15-21 parts of pseudo-ginseng, 20-30 parts of safflower, 30-40 parts of szechuan lovage rhizome, 15-25 parts of myrrh, 15-25 parts of zedoary turmeric, 30-40 parts of Chinese angelica, 1-10 parts of wintergreen oil, 1-5 parts of eucalyptus oil, 0.5-1.0 part of clove oil, 1-4 parts of camphor, 1-2 parts of menthol, 1-3 parts of borneol, 3-8 parts of hydrogenated castor oil and 0.5-4 parts of penetrating agent.
Optionally, the penetrating agent is at least one of laurocapram and tetrahydropiperine.
Optionally, the penetrating agent is 1-3 parts of laurocapram and 0.5-1 part of tetrahydropiperine.
A preparation method of a traditional Chinese medicine composition for relaxing tendons and activating collaterals comprises the following steps:
(1) Weighing pseudo-ginseng, safflower, szechuan lovage rhizome, myrrh, zedoary and Chinese angelica according to parts by weight, grinding, pulverizing and sieving to obtain traditional Chinese medicine powder;
(2) Soaking the Chinese medicinal powder in ethanol, stirring while heating with microwave, and reflux-extracting at constant temperature for 24-48 hr to obtain extract mixture;
(3) Standing the extraction mixture, and filtering the supernatant to obtain an extract serving as phase A;
(4) Weighing the extract and ethanol, slowly adding the ethanol into the phase A, and uniformly stirring;
(5) Slowly adding the weighed penetrating agent into the phase A, and uniformly stirring;
(6) Mixing wintergreen oil, oleum Eucalypti, oleum Caryophylli, camphora, mentholum, borneolum Syntheticum and hydrogenated castor oil, heating to 50deg.C, stirring and mixing to dissolve completely to obtain phase B;
(7) Slowly adding the phase B into the phase A, mixing and stirring, homogenizing, stirring and defoaming to obtain the traditional Chinese medicine composition for relaxing tendons and activating collaterals.
Optionally, the concentration of ethanol in step (2) is 50% -75%.
Optionally, the concentration of ethanol in step (4) is 75%.
Optionally, the constant temperature in step (2) is 50 ℃ to 60 ℃.
Pharmacological actions of the traditional Chinese medicine components in the raw materials:
pseudo-ginseng: has the effects of stopping bleeding, removing blood stasis, relieving swelling and pain.
Safflower: dried flowers of safflower belonging to Compositae. Pungent and warm in nature. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochia, abdominal mass, chest pain, abdominal pain due to stagnation, chest and hypochondrium stabbing pain, traumatic injury, and pyocutaneous disease swelling and pain.
Ligusticum wallichii: pungent taste and warm nature, activate blood and promote qi circulation, dispel wind and alleviate pain; can be used for soothing nerves, relieving headache, abdominal pain, stabbing pain in chest and hypochondrium, swelling and pain from traumatic injury, headache, and rheumatalgia.
Myrrh: promoting blood circulation, removing blood stasis, relieving swelling and pain, promoting granulation, healing sore and healing wound.
Zedoary turmeric: the property of the herb is pungent and bitter and warm, and is attributed to the liver and spleen meridians; has effects in promoting qi circulation, removing blood stasis, removing food retention, and relieving pain; it is mainly used for treating abdominal mass due to blood stasis, amenorrhea, thoracoabdominal hypochondrium and other symptoms due to blood stasis.
Chinese angelica root: the root and rhizome of Angelica sinensis (oliv.) Diels of Umbelliferae are sweet in taste, pungent in nature, warm in nature, and capable of replenishing blood; activating blood; regulating menstruation and relieving pain; moisten dryness and smooth the intestines.
The application has the following beneficial effects: 1) Selecting high-quality traditional Chinese medicinal materials, and performing a scientific and efficient extraction method to quench the active ingredients of the traditional Chinese medicinal materials with high activity; 2) Scientific penetrant collocation is adopted to promote the absorption of effective matters; 3) Proper amount of chemical components other than traditional Chinese medicines can be added, so that the timely effect is improved, the compound synergy is carried out with the traditional Chinese medicines, and the traditional Chinese medicines are timely combined with long-acting effects, so that the pain can be relieved, the swelling can be removed, the blood stasis can be removed, and the long-acting deep penetration can be carried out, and the traditional Chinese medicines can be cured gradually; 4) The components are compounded according to the principle of monarch, minister, assistant and guide, and have the effects of dredging channels and activating collaterals, activating blood circulation and relieving pain, softening hardness and resolving hard mass and dissolving bone spurs.
Detailed Description
The present invention will be further described with reference to examples, but the scope of the invention as claimed is not limited to the scope expressed by the examples.
Example 1
A traditional Chinese medicine composition for relaxing tendons and activating collaterals comprises the following raw materials in parts by weight: 15 parts of pseudo-ginseng, 20 parts of safflower, 30 parts of szechuan lovage rhizome, 15 parts of myrrh, 15 parts of zedoary, 30 parts of Chinese angelica, 3 parts of wintergreen oil, 2 parts of eucalyptus oil, 0.5 part of clove oil, 3.5 parts of camphor, 2 parts of menthol, 2.5 parts of borneol, 7 parts of hydrogenated castor oil and 1 part of laurocapram.
The preparation method comprises the following steps:
(1) Weighing the traditional Chinese medicine components according to the weight parts, grinding and powdering, and sieving with a 100-200 mesh sieve to obtain traditional Chinese medicine powder;
(2) Soaking the traditional Chinese medicine powder in 250 parts of ethanol with the concentration of 50%, stirring while heating by microwaves in the soaking process, keeping the temperature between 50 and 60 ℃, and performing condensation reflux extraction for 24 to 48 hours to obtain an extraction mixture;
(3) Standing the extraction mixture, and filtering the supernatant with 800-mesh filter cloth to obtain an extract as phase A;
(4) 39.25 parts of extract and 39.25 parts of ethanol with the concentration of 75% are weighed, and the ethanol is slowly added into the phase A and stirred uniformly;
(5) Slowly adding the weighed penetrant laurocapram into the phase A, and uniformly stirring;
(6) Mixing wintergreen oil, oleum Eucalypti, oleum Caryophylli, camphora, mentholum, borneolum Syntheticum and hydrogenated castor oil, heating to 50deg.C, stirring and mixing to dissolve completely to obtain phase B;
(7) Slowly adding the phase B into the phase A, mixing and stirring, homogenizing at high speed for 5 min, and stirring for 20 min for defoaming to obtain the traditional Chinese medicine composition for relaxing tendons and activating collaterals.
Examples 2 to 6
The Chinese medicinal composition for relaxing tendons and activating collaterals comprises the following medicinal materials in proportion in table 1:
table 1: traditional Chinese medicine extract raw materials table (/ part) of different embodiments
The "2 times, 50%" in the extract A of Table 1 above indicates that the amount of ethanol added at 50% concentration is 2 times the total parts of the Chinese medicinal materials, and the amounts and descriptions of ethanol in other extracts are similar.
Table 2: table of raw materials (/ parts) for the different examples
Extracts A-F were prepared according to the data of Table 1 and the preparation steps (1) - (3) of example 1, respectively; the preparation steps (4) - (7) of example 1 and the data of table 2 were used to prepare the tendon-relaxing and collateral-activating Chinese medicinal compositions of examples 2-6, respectively, wherein 75% ethanol was not added in the preparation step (4) of examples 4-6.
The refractive index, the active matter content and the residue remaining amount of the extract A-F are measured to obtain the following data:
table 3: extraction data of Chinese medicine of different embodiments
Wherein, 1) the refractive index is detected by adopting a refractometer, and the deeper the color and luster of the same proportion, the better the extraction effect; 2) Active matter content calculation: taking the weight M of the extract, baking at 200 ℃ for 4 hours to obtain the weight M2 of the solid, and calculating the formula M2/M = active matter content; 3) Extraction rate: adding the total weight M of the Chinese medicines, and baking the residues obtained after extraction at 200 ℃ for 4 hours to obtain residues M1 without water and alcohol residues, (M-M1)/M=extraction rate.
As can be seen from Table 3, the Chinese medicinal extract liquid prepared by the invention can not only maintain the activity of Chinese medicaments, but also extract the active substances of Chinese medicaments with high efficiency. Examples 3 and 6 gave higher extraction rates, indicating that the higher the alcohol concentration level, the higher the extraction rate; if the later-stage medicine is a high-concentration Chinese medicine liquid, the method of the example 3 is selected, and if the later-stage medicine is a low-concentration Chinese medicine liquid, the method of the example 6 is selected to extract the Chinese medicine liquid into an optimal extraction mode.
Test items:
irritation test: the traditional Chinese medicine composition for relaxing tendons and activating collaterals prepared in the examples 1-6 is used for spot application experiments, equal samples are taken for single and multiple times of administration to the back skin of the same person, and the administration is carried out for 30 minutes, 1 hour, 4 hours, 8 hours, 12 hours, 24 hours, and the skin irritation change is observed.
Absorption rate: pigskin was taken and divided into 1cm x 1cm areas, and the complete absorption time was recorded for the administration of the same amount and multiple areas.
Transdermal strength: the pig skin drug was completely absorbed for 10 minutes, 30 minutes, 1 hour, 3 hours, and the penetration depth was observed as a transdermal force test.
Data comparison:
table 4: data comparison of different embodiments
| Test item | Irritation (irritation) | Absorption rate | Transdermal force |
| Example 1 | ++ | + | + |
| Example 2 | +++ | ++ | ++ |
| Example 3 | ++++ | ++ | +++ |
| Example 4 | + | + | + |
| Example 5 | + | ++ | ++ |
| Example 6 | + | ++ | ++ |
Analysis of the irritation can result in example 4, example 5, example 6 being a preferred protocol formulation, through comparison of the data in table 4; the preferred protocol for analysis of absorption rate is example 2, example 3, example 5, example 6; comparative skin penetration a preferred protocol formulation was found to be example 2, example 3, example 5, example 6. The comprehensive analysis results in more preferable schemes of example 5 and example 6, and the comparison of the cost performance of two formulas results in example 5 as the final preferable scheme.
Trial verification was performed on 70 patients aged 25-70 years, with 15 patients with shoulder joint pain as complaints, 17 patients with hip joint pain as complaints, 20 patients with lumbar joint pain as complaints, and 18 patients with limb pain as complaints. 70 patients apply the traditional Chinese medicine composition for relaxing tendons and activating collaterals obtained in the example 5 to the affected part every day, wherein the treatment course is 1 month, and the curative effect is confirmed after taking 3 treatment courses.
The efficacy evaluation criteria were as follows:
and (3) curing: the clinical symptoms disappear and no recurrence occurs within 1 year.
The effect is shown: the main symptoms disappeared.
The method is effective: the main symptoms and signs are obviously improved.
Invalidation: there was no improvement in symptoms signs compared to pre-treatment.
The treatment data were as follows:
and (3) curing: 34 cases were obtained, among which 8 cases were obtained for shoulder joint pain, 8 cases were obtained for hip joint pain, 11 cases were obtained for lumbar joint pain, and 7 cases were obtained for limb pain.
The effect is shown: 21 cases were total, of which there were 4 cases of shoulder joint pain patients, 5 cases of hip joint pain patients, 4 cases of lumbar joint pain patients, and 8 cases of limb pain.
The method is effective: 11 cases were total, of which shoulder pain patients were 2 cases, hip pain patients were 4 cases, lumbar pain patients were 2 cases, and limb pain was 3 cases.
Invalidation: 4 cases were total, of which 1 case was the case with shoulder joint pain and 3 cases with lumbar joint pain.
The cure rate of the traditional Chinese medicine composition for relaxing tendons and activating collaterals is 48.57%, the obvious efficiency is 30.00%, the effective rate is 15.71%, and the total effective rate is 94.28%. Therefore, the traditional Chinese medicine composition for relaxing tendons and activating collaterals has the effects of relaxing muscles and activating collaterals, activating blood circulation and removing blood stasis, and relieving swelling and pain, and can be used for treating diseases such as rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, lumbar spondylosis and the like.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the present invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (6)
1. The traditional Chinese medicine composition for relaxing tendons and activating collaterals is characterized by being prepared from the following raw materials in parts by weight: 15-26 parts of pseudo-ginseng, 20-35 parts of safflower, 30-50 parts of szechuan lovage rhizome, 15-30 parts of myrrh, 15-30 parts of zedoary turmeric, 30-50 parts of Chinese angelica, 1-15 parts of wintergreen oil, 1-8 parts of eucalyptus oil, 0.5-1.5 parts of clove oil, 1-6 parts of camphor, 1-3 parts of menthol, 1-5 parts of borneol, 3-10 parts of hydrogenated castor oil and 0.5-4 parts of penetrating agent; the penetrating agent is at least one of laurocapram and tetrahydropiperine;
the traditional Chinese medicine composition for relaxing tendons and activating collaterals is prepared by the following method:
(1) Weighing pseudo-ginseng, safflower, szechuan lovage rhizome, myrrh, zedoary and Chinese angelica according to parts by weight, grinding, pulverizing and sieving to obtain traditional Chinese medicine powder;
(2) Soaking the Chinese medicinal powder in ethanol, stirring while heating with microwave, and reflux-extracting at constant temperature for 24-48 hr to obtain extract mixture;
(3) Standing the extraction mixture, and filtering the supernatant to obtain an extract serving as phase A;
(4) Weighing the extract and ethanol, slowly adding the ethanol into the phase A, and uniformly stirring;
(5) Slowly adding the weighed penetrating agent into the phase A, and uniformly stirring;
(6) Mixing wintergreen oil, oleum Eucalypti, oleum Caryophylli, camphora, mentholum, borneolum Syntheticum and hydrogenated castor oil, heating to 50deg.C, stirring and mixing to dissolve completely to obtain phase B;
(7) Slowly adding the phase B into the phase A, mixing and stirring, homogenizing, stirring and defoaming to obtain the traditional Chinese medicine composition for relaxing tendons and activating collaterals.
2. The traditional Chinese medicine composition for relaxing tendons and activating collaterals according to claim 1 is characterized by being prepared from the following raw materials in parts by weight: 15-21 parts of pseudo-ginseng, 20-30 parts of safflower, 30-40 parts of szechuan lovage rhizome, 15-25 parts of myrrh, 15-25 parts of zedoary turmeric, 30-40 parts of Chinese angelica, 1-10 parts of wintergreen oil, 1-5 parts of eucalyptus oil, 0.5-1.0 part of clove oil, 1-4 parts of camphor, 1-2 parts of menthol, 1-3 parts of borneol, 3-8 parts of hydrogenated castor oil and 0.5-4 parts of penetrating agent.
3. The traditional Chinese medicine composition for relaxing tendons and activating collaterals according to claim 1, wherein the penetrating agent is 1-3 parts of laurocapram and 0.5-1 part of tetrahydropiperine.
4. The traditional Chinese medicine composition for relaxing tendons and activating collaterals according to claim 1, wherein the concentration of ethanol in the step (2) is 50% -75%.
5. The traditional Chinese medicine composition for relaxing tendons and activating collaterals according to claim 1, wherein the concentration of ethanol in the step (4) is 75%.
6. The traditional Chinese medicine composition for relaxing tendons and activating collaterals according to claim 1, wherein the constant temperature in the step (2) is 50-60 ℃.
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