CN114306458A - A Chinese medicinal composition for treating hyperosteogeny, and its preparation method - Google Patents
A Chinese medicinal composition for treating hyperosteogeny, and its preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating hyperosteogeny and a preparation method thereof, relating to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating hyperosteogeny comprises the following raw materials in parts by weight: 20-45 parts of clematis root, 20-45 parts of drynaria rhizome, 20-45 parts of notopterygium root, 20-45 parts of radix angelicae pubescentis, 8-12 parts of asarum, 8-15 parts of fructus evodiae, 8-15 parts of pepper, 8-15 parts of cinnamon, 20-45 parts of ground beeltle, 8-15 parts of clove, 20-45 parts of anemone rivularis and 20-45 parts of corydalis tuber; it can effectively treat hyperosteogeny pain, osteoarthritis and other symptoms with obvious treatment effect. The preparation method has simple process, and the prepared product has good therapeutic effect and convenient use.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating hyperosteogeny and a preparation method thereof.
Background
Hyperosteogeny is a common orthopedic disease, and is mostly seen in people of 35-70 years old. With the increasing age of human beings, degenerative changes of tissues such as muscles, ligaments and the like around the spine and joints of the human body occur, so that the balance of the spine and the joints is damaged, instability of the spine and the joints can occur successively, and bone spurs can occur in order to adapt to the changes of the body per se to increase the surface area of bones, so that the pressure per unit area of the bones is reduced. No obvious symptoms under normal conditions; less symptomatic patients often present with persistent dull pain in the affected joint; severe symptoms such as severe pain, numbness, convulsion and the like can be generated, and even serious consequences of disability and paralysis can be generated, so that the daily life and life safety of the patient are seriously influenced.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating hyperosteogeny, which can effectively treat symptoms such as hyperosteogeny pain, osteoarthritis and the like and has obvious treatment effect.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating the hyperosteogeny, the method has simple process, and the prepared product has good medicine treatment effect and convenient use.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the invention provides a traditional Chinese medicine composition for treating hyperosteogeny, which comprises the following raw materials in parts by weight: 20-45 parts of clematis root, 20-45 parts of drynaria rhizome, 20-45 parts of notopterygium root, 20-45 parts of radix angelicae pubescentis, 8-12 parts of asarum, 8-15 parts of fructus evodiae, 8-15 parts of pepper, 8-15 parts of cinnamon, 20-45 parts of ground beeltle, 8-15 parts of clove, 20-45 parts of anemone rivularis and 20-45 parts of corydalis tuber.
On the other hand, the embodiment of the invention provides a preparation method of a traditional Chinese medicine composition for treating hyperosteogeny, which comprises the following steps: pulverizing and sieving radix Clematidis, rhizoma Drynariae, Notopterygii rhizoma, radix Angelicae Pubescentis, herba asari, fructus evodiae, fructus Zanthoxyli, cortex Cinnamomi, Eupolyphaga Seu Steleophaga, flos Caryophylli, radix seu folium Jasmini Lanceolatae, and rhizoma corydalis, respectively, decocting in water twice, and filtering to obtain decoction and residue; concentrating and drying the decoction to obtain extract; mixing the extract and the residue, adding white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
aiming at the first aspect, the embodiment of the invention provides a traditional Chinese medicine composition for treating hyperosteogeny, which comprises the following raw materials in parts by weight: 20-45 parts of clematis root, 20-45 parts of drynaria rhizome, 20-45 parts of notopterygium root, 20-45 parts of radix angelicae pubescentis, 8-12 parts of asarum, 8-15 parts of fructus evodiae, 8-15 parts of pepper, 8-15 parts of cinnamon, 20-45 parts of ground beeltle, 8-15 parts of clove, 20-45 parts of anemone rivularis and 20-45 parts of corydalis tuber.
In the above examples, the effects of the raw materials are as follows:
clematis root: expelling wind-damp, dredging channels and collaterals, eliminating phlegm and saliva, and dispersing accumulation of pathogen; it can be used for treating gout, obstinate arthralgia, cold pain of waist and knee, loempe, malaria, abdominal mass, tetanus, tonsillitis, and bone sticking throat.
Rhizoma drynariae: tonifying kidney, strengthening bone, healing wound and relieving pain; can be used for treating lumbago due to kidney deficiency, tinnitus, deafness, odontoseisis, traumatic injury, contusion, and fracture of bones and muscles; it is used externally to treat alopecia areata and vitiligo.
Notopterygium root: dispel exterior cold, dispel wind-damp, benefit the joint; it is used to treat common cold, wind-cold, headache, anhidrosis, arthralgia due to wind-cold-dampness, stiff neck, soreness of joints, edema due to wind-damp, carbuncle, sore and toxin.
Radix angelicae pubescentis: dispelling pathogenic wind, eliminating dampness, dispelling cold, and relieving pain; it can be used for treating arthralgia due to wind-cold-dampness, soreness of waist and knees, contracture pain of hands and feet, chronic tracheitis, headache, and toothache.
Asarum: expelling wind and cold, inducing resuscitation and relieving pain, warming lung and resolving fluid retention; can be used for treating wind-cold type common cold, headache, toothache, nasal obstruction, nasosinusitis, rheumatalgia, phlegm retention, asthma, and cough.
Evodia fruit: dispel cold and alleviate pain, check adverse rise of qi and arrest vomiting, strengthen yang and check diarrhea; can be used for treating syncope headache, cold hernia abdominal pain, cold dampness loempe, dysmenorrhea, abdominal distention and pain, emesis, acid regurgitation, morning diarrhea, aphtha, and hypertension.
Chinese prickly ash: warming the middle-jiao to dispel cold, removing dampness, relieving pain, killing parasite, and removing fishy smell; it is used to treat retention of food and drink, psychroalgia of heart and abdomen, emesis, hiccup, cough, adverse qi, anemofrigid-damp arthralgia, diarrhea, dysentery, hernia pain, toothache, ascariasis, enterobiasis, pudendal pruritus, sore, and scabies.
Cinnamon: replenishing fire and supporting yang, guiding fire to the source, dispelling cold and relieving pain, and promoting blood circulation and stimulating the menstrual flow; can be used for treating sexual impotence, cold womb, psychroalgia of waist and knee, asthma due to kidney deficiency, vertigo due to yang deficiency, conjunctival congestion, pharyngalgia, psychroalgia of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, galloping, amenorrhea, and dysmenorrhea.
Ground beetle: promoting blood circulation, removing blood stasis, dredging channels, and relieving pain; it is mainly used for traumatic injury, swelling and pain due to blood stasis, amenorrhea, and postpartum abdominal pain due to blood stasis.
Clove: warming middle energizer to lower adverse flow, invigorating kidney and tonifying yang; can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.
Breaking bone wind: dispelling pathogenic wind, removing dampness, promoting blood circulation, and relieving pain; it is indicated for pain in waist, legs and joints due to wind-damp, traumatic injuries, sore, abscess and deep-rooted carbuncle.
Rhizoma corydalis: promoting blood circulation, removing blood stasis, regulating qi, and relieving pain; it is used to treat pain of heart, abdomen, waist and knee, menoxenia, abdominal mass, metrorrhagia, puerperal dizziness, lochiorrhea, and traumatic injury.
In the raw material components of the traditional Chinese medicine composition for treating the hyperosteogeny, clematis root contains anemonin, oleanolic acid and other substances, and has the effects of reducing blood pressure and blood sugar and relieving pain; the drynaria contains various substances such as naringin, stigmasterol and the like, has the effects of promoting the healing of bone injury, reducing the osteoarthropathy rate and resisting bacteria, and can prevent the formation of atherosclerotic plaques on the artery wall; the notopterygium root contains various substances such as coumarins and fatty acids, and has antipyretic, anti-inflammatory, analgesic and antiarrhythmic effects; radix Angelicae Pubescentis contains multiple substances such as dihydrocarveol and phorbole, and has spasmolytic, analgesic, antiinflammatory, antibacterial and tranquilizing effects; the asarum volatile oil contains various substances such as methyl eugenol and the like, has the effects of relieving fever, easing pain and inhibiting bacteria, and also has the effect of regulating blood pressure; fructus evodiae contains volatile oil, alkaloids, etc., and has effects of expelling parasites, resisting bacteria, relieving pain, resisting inflammation, tranquilizing, regulating blood pressure, protecting intestine and stomach, and relieving vomit and diarrhea; the pepper contains various substances such as volatile oil, sterol, unsaturated organic acid and the like, and has the effects of easing pain, inhibiting bacteria, expelling parasites and the like; the cinnamon volatile oil contains various substances such as cinnamaldehyde and cinnamyl acetate, and has the effects of tranquilizing, cooling, sterilizing, reducing blood pressure and the like; the ground beetle contains volatile oil and amino acid, has the effects of dissolving thrombus, reducing blood fat, promoting bone fracture healing, protecting liver, resisting tumor and the like; the clove contains various substances such as eugenol and the like, and has the effects of resisting bacteria and fungi, expelling parasites, invigorating stomach, relieving pain, detoxifying and the like; the radix seu folium Jasmini Lanceolatae contains oleanolic acid, and has hemostatic, analgesic, pathogenic wind expelling, and dampness removing effects; the corydalis tuber contains various alkaloids, has obvious effects of easing pain and tranquilizing, and has certain effects of relieving fever and cooling.
In traditional Chinese medicine, the hyperosteogeny is generally considered to be caused by deficiency of vital qi of a human body, deficiency of spleen and kidney, and deficiency of wind, cold and damp evil; or injury of waist due to sudden fall, contusion, overstrain, injury of channels, and obstruction of qi and blood. In the traditional Chinese medicine composition, the raw medicinal materials are mutually combined and matched, the synergistic effect is realized, and the cinnamon and the clove are mutually matched, so that the effects of nourishing and tonifying spleen and kidney, and tonifying fire and supporting yang are achieved; the clematis root, the notopterygium root, the radix angelicae pubescentis, the asarum, the evodia rutaecarpa and the pepper are matched to play roles in dispelling wind and removing dampness, warming the middle-jiao and dispelling cold; and the rhizoma drynariae, the ground beetle, the radix sileris and the rhizoma corydalis are matched to play roles in activating blood circulation, dissipating blood stasis and strengthening muscles and bones. Meanwhile, the raw medicinal materials contain various effective components which can play a role in resisting inflammation, easing pain, resisting bacteria and detoxifying, can effectively play a role in relieving and treating diseases such as hyperosteogeny pain and arthritis, and has an excellent treatment effect.
In view of the second aspect, the embodiment of the present invention provides a preparation method of a traditional Chinese medicine composition for treating hyperosteogeny, which includes the following steps: pulverizing and sieving radix Clematidis, rhizoma Drynariae, Notopterygii rhizoma, radix Angelicae Pubescentis, herba asari, fructus evodiae, fructus Zanthoxyli, cortex Cinnamomi, Eupolyphaga Seu Steleophaga, flos Caryophylli, radix seu folium Jasmini Lanceolatae, and rhizoma corydalis, respectively, decocting in water twice, and filtering to obtain decoction and residue; concentrating and drying the decoction to obtain extract; mixing the extract and the residue, adding white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
The preparation method of the traditional Chinese medicine composition for treating hyperosteogeny comprises the steps of crushing and sieving the clematis root, the drynaria rhizome, the notopterygium root, the heracleum hemsleyanum michaux, the asarum, the evodia rutaecarpa, the pepper, the cinnamon, the ground beeltle, the clove, the anemone broussuriensis and the corydalis tuber, and controlling the particle size of the crushed medicine so that the particle size is not too large or too small, thereby facilitating the subsequent extraction of beneficial ingredients in medicinal materials and being beneficial to the full utilization of the medicine. Then the crushed medicine is added with water for decoction, and the effective components in the raw medicinal materials are extracted by decoction, so that the effective components in the medicine can better exert respective effects, and the medicine is more beneficial to treatment and use. Then the filtered decoction is concentrated and dried to obtain an extract, the extract is mixed with the medicine residues, white vinegar or white spirit is added, the mixture is stirred and mixed into a thick paste, and then the finished product medicine is prepared.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a traditional Chinese medicine composition for treating hyperosteogeny, which comprises the following raw materials in parts by weight: 20-45 parts of clematis root, 20-45 parts of drynaria rhizome, 20-45 parts of notopterygium root, 20-45 parts of radix angelicae pubescentis, 8-12 parts of asarum, 8-15 parts of fructus evodiae, 8-15 parts of pepper, 8-15 parts of cinnamon, 20-45 parts of ground beeltle, 8-15 parts of clove, 20-45 parts of anemone rivularis and 20-45 parts of corydalis tuber.
In the above examples, clematis root, which is a raw material component, contains anemonin, oleanolic acid and other various substances, and has the effects of reducing blood pressure and blood sugar and relieving pain; the drynaria contains various substances such as naringin, stigmasterol and the like, has the effects of promoting the healing of bone injury, reducing the osteoarthropathy rate and resisting bacteria, and can prevent the formation of atherosclerotic plaques on the artery wall; the notopterygium root contains various substances such as coumarins and fatty acids, and has antipyretic, anti-inflammatory, analgesic and antiarrhythmic effects; radix Angelicae Pubescentis contains multiple substances such as dihydrocarveol and phorbole, and has spasmolytic, analgesic, antiinflammatory, antibacterial and tranquilizing effects; the asarum volatile oil contains various substances such as methyl eugenol and the like, has the effects of relieving fever, easing pain and inhibiting bacteria, and also has the effect of regulating blood pressure; fructus evodiae contains volatile oil, alkaloids, etc., and has effects of expelling parasites, resisting bacteria, relieving pain, resisting inflammation, tranquilizing, regulating blood pressure, protecting intestine and stomach, and relieving vomit and diarrhea; the pepper contains various substances such as volatile oil, sterol, unsaturated organic acid and the like, and has the effects of easing pain, inhibiting bacteria, expelling parasites and the like; the cinnamon volatile oil contains various substances such as cinnamaldehyde and cinnamyl acetate, and has the effects of tranquilizing, cooling, sterilizing, reducing blood pressure and the like; the ground beetle contains volatile oil and amino acid, has the effects of dissolving thrombus, reducing blood fat, promoting bone fracture healing, protecting liver, resisting tumor and the like; the clove contains various substances such as eugenol and the like, and has the effects of resisting bacteria and fungi, expelling parasites, invigorating stomach, relieving pain, detoxifying and the like; the radix seu folium Jasmini Lanceolatae contains oleanolic acid, and has hemostatic, analgesic, pathogenic wind expelling, and dampness removing effects; the corydalis tuber contains various alkaloids, has obvious effects of easing pain and tranquilizing, and has certain effects of relieving fever and cooling.
In traditional Chinese medicine, the hyperosteogeny is generally considered to be caused by deficiency of vital qi of a human body, deficiency of spleen and kidney, and deficiency of wind, cold and damp evil; or injury of waist due to sudden fall, contusion, overstrain, injury of channels, and obstruction of qi and blood. In the traditional Chinese medicine composition, the raw medicinal materials are mutually combined and matched, the synergistic effect is realized, and the cinnamon and the clove are mutually matched, so that the effects of nourishing and tonifying spleen and kidney, and tonifying fire and supporting yang are achieved; the clematis root, the notopterygium root, the radix angelicae pubescentis, the asarum, the evodia rutaecarpa and the pepper are matched to play roles in dispelling wind and removing dampness, warming the middle-jiao and dispelling cold; and the rhizoma drynariae, the ground beetle, the radix sileris and the rhizoma corydalis are matched to play roles in activating blood circulation, dissipating blood stasis and strengthening muscles and bones. Meanwhile, the raw medicinal materials contain various effective components which can play a role in resisting inflammation, easing pain, resisting bacteria and detoxifying, can effectively play a role in relieving and treating diseases such as hyperosteogeny pain and arthritis, and has an excellent treatment effect.
Further, in some embodiments of the present invention, the raw materials are used in the following amounts by weight: 30 parts of clematis root, 30 parts of drynaria rhizome, 30 parts of notopterygium root, 30 parts of pubescent angelica root, 10 parts of asarum, 10 parts of evodia rutaecarpa, 10 parts of pepper, 10 parts of cinnamon, 30 parts of ground beetle, 10 parts of clove, 30 parts of radix sileris and 30 parts of corydalis tuber.
In the above embodiment, the dosage ratio of each raw material drug is further limited, so that the drug ratio is more reasonable, the raw material drugs can better exert respective beneficial effects, the medicinal materials can be better combined and matched, the synergy is realized, the treatment effect of the product drug is further promoted, and the treatment and use are more facilitated.
Further, in some embodiments of the present invention, the raw material further comprises white vinegar or white spirit, and the weight percentage of the white vinegar or white spirit is 20-50%.
In the above embodiments, the white vinegar has the effects of removing blood stasis, stopping bleeding, detoxifying and killing insects; the Chinese liquor has effects of promoting blood circulation, resisting cold and promoting medicinal trend. The white vinegar or the white spirit is used as an auxiliary material, is added into the medicine and is mixed and applied to the affected part, so that the analgesic effect of the medicine on the affected part of the joint is further enhanced, the treatment effect of the product medicine on diseases such as hyperosteogeny pain and arthritis is enhanced, meanwhile, the transdermal absorption of the medicine is promoted, the medicine effect can be fully absorbed by the organism, and the therapeutic use is facilitated.
Further, in some embodiments of the present invention, the above ground beetle is replaced by centipede.
In the above embodiments, the centipede has the effects of calming endogenous wind, relieving spasm, removing toxic materials, resolving masses, dredging collaterals and relieving pain, has obvious antibacterial and anti-tumor effects, is beneficial to improving the immunity of the organism, and is more beneficial to treatment and use.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for treating hyperosteogeny, which comprises the following steps: pulverizing and sieving radix Clematidis, rhizoma Drynariae, Notopterygii rhizoma, radix Angelicae Pubescentis, herba asari, fructus evodiae, fructus Zanthoxyli, cortex Cinnamomi, Eupolyphaga Seu Steleophaga, flos Caryophylli, radix seu folium Jasmini Lanceolatae, and rhizoma corydalis, respectively, decocting in water twice, and filtering to obtain decoction and residue; concentrating and drying the decoction to obtain extract; mixing the extract and the residue, adding white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Further, in some embodiments of the present invention, 10 times of the weight of the raw material of water is added for each decoction, and the time for each decoction is 2 hours.
In the embodiment, by controlling the amount of water and the decocting time during decocting, the effective components in the raw material medicines can be extracted more fully, so that the drug effect of the product medicine is further enhanced, the respective beneficial effects of the raw material medicines can be fully exerted, and the treatment and the use are more facilitated.
Further, in some embodiments of the invention, the decoction is concentrated to a relative density of 1.10-1.20, and then spray dried.
In the embodiment, the relative density of the concentrated decoction is controlled, so that the concentrated decoction can keep proper viscosity and fluidity, the subsequent spray drying step can be performed smoothly, the spray drying efficiency can be improved, and the quality of the product medicine can be further improved.
Further, in some embodiments of the invention, the spray drying is performed at an inlet air temperature of 150 ℃.
In the above embodiment, the air inlet temperature of the spray drying is controlled, so that the concentrated decoction can be better dried, the drying efficiency is improved, the occurrence of wall sticking can be avoided, the quality of the product medicine can be further improved, and the treatment and the use are more facilitated.
Further, in some embodiments of the present invention, the mesh number of the screen is 40 mesh.
In the above embodiment, through restricting the mesh number of sieve to control the particle size of smashing back raw material medicinal material granule, help better follow-up in step to draw out the active ingredient in the medicinal material, also be favorable to simultaneously carrying out the recycle to the dregs of a decoction after drawing, make the respective beneficial efficiency of medicinal material full play, avoid causing the extravagant loss of medicine, help further promoting the treatment of product medicine, more be favorable to the treatment to use.
Further, in some embodiments of the invention, the extract is mixed with the residue at 60 ℃, and white vinegar or white wine is added and mixed with stirring.
In the embodiment, the extract and the medicine residues are mixed at 60 ℃, and the white vinegar or the white spirit is added for stirring and mixing, so that the components can be well and fully mixed together, the components can be better combined and matched with each other, the drug effect of the product medicine can be further improved, and the relieving and treating effects of the product medicine on diseases such as hyperosteogeny, osteoarthritis and the like can be enhanced.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating hyperosteogeny, which is prepared by the following method:
respectively crushing 25g of radix clematidis, 30g of rhizoma drynariae, 30g of notopterygium root, 30g of radix angelicae pubescentis, 8g of asarum, 15g of fructus evodiae, 8g of pepper, 10g of cinnamon, 20g of ground beetle, 12g of clove, 20g of radix sileris and 20g of rhizoma corydalis, sieving the crushed materials with a 40-mesh sieve, adding water for repeatedly decocting twice, adding 10 times of water by weight of the raw materials into each decoction, and keeping the decocting time for 2 hours; then filtering to obtain decoction and dregs; concentrating the decoction to relative density of 1.15, and spray drying at 150 deg.C to obtain extract; mixing the extract and the residues at 60 deg.C, adding 30 wt% of white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating hyperosteogeny, which is prepared by the following method:
respectively crushing 40g of radix clematidis, 38g of rhizoma drynariae, 22g of notopterygium root, 25g of radix angelicae pubescentis, 12g of asarum, 15g of fructus evodiae, 12g of pepper, 14g of cinnamon, 25g of ground beetle, 15g of clove, 30g of radix sileris and 30g of rhizoma corydalis, sieving the crushed materials with a 40-mesh sieve, adding water for repeatedly decocting twice, adding water with the weight 10 times of the raw materials for each time, and keeping the decocting time for 2 hours; then filtering to obtain decoction and dregs; concentrating the decoction to relative density of 1.20, and spray drying at 150 deg.C to obtain extract; mixing the extract and the residues at 60 deg.C, adding 45 wt% of white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating hyperosteogeny, which is prepared by the following method:
respectively crushing 30g of radix clematidis, 25g of rhizoma drynariae, 35g of notopterygium root, 25g of radix angelicae pubescentis, 8g of asarum, 10g of fructus evodiae, 10g of pepper, 10g of cinnamon, 30g of ground beetle, 10g of clove, 25g of radix sileris and 30g of rhizoma corydalis, sieving the crushed materials with a 40-mesh sieve, adding water for repeatedly decocting twice, adding water with the weight 10 times of the raw materials for each time, and keeping the decocting time for 2 hours; then filtering to obtain decoction and dregs; concentrating the decoction to relative density of 1.15, and spray drying at 150 deg.C to obtain extract; mixing the extract and the residues at 60 deg.C, adding 35 wt% of white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating hyperosteogeny, which is prepared by the following method:
respectively crushing 30g of radix clematidis, 30g of rhizoma drynariae, 30g of notopterygium root, 30g of radix angelicae pubescentis, 10g of asarum, 10g of fructus evodiae, 10g of pepper, 10g of cinnamon, 30g of ground beetle, 10g of clove, 30g of radix sileris and 30g of rhizoma corydalis, sieving the crushed materials with a 40-mesh sieve, adding water for repeatedly decocting twice, adding 10 times of water by weight of the raw materials into each decoction, and keeping the decocting time for 2 hours; then filtering to obtain decoction and dregs; concentrating the decoction to relative density of 1.20, and spray drying at 150 deg.C to obtain extract; mixing the extract and the residues at 60 deg.C, adding 40 wt% of white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating hyperosteogeny, which is prepared by the following method:
respectively crushing 30g of radix clematidis, 25g of rhizoma drynariae, 30g of notopterygium root, 30g of radix angelicae pubescentis, 10g of asarum, 10g of fructus evodiae, 10g of pepper, 15g of cinnamon, 22g of ground beetle, 15g of clove, 32g of radix sileris and 25g of rhizoma corydalis, sieving the crushed materials with a 40-mesh sieve, adding water for repeatedly decocting twice, adding water with the weight 10 times of the raw materials for each time, and keeping the decocting time for 2 hours; then filtering to obtain decoction and dregs; concentrating the decoction to relative density of 1.15, and spray drying at 150 deg.C to obtain extract; mixing the extract and the residue at 60 deg.C, adding 20-50 wt% of white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
Test examples
Treatment and observation were performed on 68 patients with hyperosteogeny, 36 male patients, 32 female patients, and age 35-65, and the patients were divided into two groups with no statistical difference (P > 0.05). One group of the Chinese medicinal compositions is used as a test group, and patients in the group are treated once a day by using the Chinese medicinal composition for treating the hyperosteogeny provided by the embodiment 4 of the invention; the other group is used as a control group, and the patients in the group are treated by using the bone hyperplasia pain-relieving plaster once a day; the treatment is continued for 14-28 days and the treatment is observed.
Patient inclusion criteria: (1) the traditional Chinese medicine composition meets the corresponding diagnosis standard, has the clinical characteristics of typical hyperosteogeny diseases and has the symptoms of pain, swelling, friction sound and the like; (2) patients received the treatment with their own knowledge and voluntary.
Patient exclusion criteria: (1) suffering from severe psychiatric disorders; (2) pregnant and lactating women; (3) suffering from other serious organ diseases; (4) those with drug allergy.
The criteria for therapeutic effect are as follows:
the method has the following advantages: the pain sensation is basically eliminated, the inflammatory reaction such as swelling and the like is basically eliminated, and the daily life is not influenced;
improvement: the pain and other inflammatory reactions are obviously relieved, and the influence on daily life is small;
and (4) invalidation: no or no significant change in symptoms compared to pre-treatment.
The results are shown in table 1:
TABLE 1
| Group of | Number of cases | Is effective | Improvement of life | Invalidation |
| Test group | 34 | 10 | 16 | 8 |
| Control group | 34 | 21 | 12 | 1 |
According to the results, compared with the traditional bone hyperplasia pain-relieving plaster, the traditional Chinese medicine composition for treating the hyperosteogeny provided by the invention has better treatment effect and is more beneficial to treatment and use.
The following are some typical cases:
liu Yi, male, 42 years old, pain in the left knee joint, particularly obvious pain after activity and in wet and cold weather, thin and white tongue coating, and soreness and weakness of waist and knees; when the traditional Chinese medicine composition for treating the hyperosteogeny provided by the invention is used, the pain feeling is obviously relieved after 3 days of treatment, the joint can normally move after one week of continuous treatment, and the influence is slight; after the continuous treatment for 14 days, all symptoms basically disappear, and the treatment effect is obvious.
Song Dynasty, women, age 52, pain and numbness in the waist and lower limbs, difficulty in getting up, and serious influence on daily life; the traditional Chinese medicine composition for treating the hyperosteogeny provided by the invention is used, the pain feeling is obviously relieved after the continuous treatment for 7 days, the activity can be basically slowly performed after 14 days, the symptoms are obviously improved after the continuous treatment for 28 days, and the treatment effect is obvious.
Liu Yi, female, 38 years old, neck and joint pain accompanied by dizziness and numbness symptoms; when the traditional Chinese medicine composition for treating the hyperosteogeny provided by the invention is used, the symptoms of dizziness and numbness are basically controlled after 3 days of continuous treatment, the pain feeling is obviously relieved, all symptoms are basically controlled after 14 days of continuous treatment, the normal activity of the neck can not be influenced, and the treatment effect is obvious.
In summary, in the traditional Chinese medicine composition for treating hyperosteogeny and the preparation method thereof provided by the embodiment of the invention, clematis root contains anemonin, oleanolic acid and other substances in the raw material components of the traditional Chinese medicine composition, so that the traditional Chinese medicine composition has the effects of reducing blood pressure and blood sugar and relieving pain; the drynaria contains various substances such as naringin, stigmasterol and the like, has the effects of promoting the healing of bone injury, reducing the osteoarthropathy rate and resisting bacteria, and can prevent the formation of atherosclerotic plaques on the artery wall; the notopterygium root contains various substances such as coumarins and fatty acids, and has antipyretic, anti-inflammatory, analgesic and antiarrhythmic effects; radix Angelicae Pubescentis contains multiple substances such as dihydrocarveol and phorbole, and has spasmolytic, analgesic, antiinflammatory, antibacterial and tranquilizing effects; the asarum volatile oil contains various substances such as methyl eugenol and the like, has the effects of relieving fever, easing pain and inhibiting bacteria, and also has the effect of regulating blood pressure; fructus evodiae contains volatile oil, alkaloids, etc., and has effects of expelling parasites, resisting bacteria, relieving pain, resisting inflammation, tranquilizing, regulating blood pressure, protecting intestine and stomach, and relieving vomit and diarrhea; the pepper contains various substances such as volatile oil, sterol, unsaturated organic acid and the like, and has the effects of easing pain, inhibiting bacteria, expelling parasites and the like; the cinnamon volatile oil contains various substances such as cinnamaldehyde and cinnamyl acetate, and has the effects of tranquilizing, cooling, sterilizing, reducing blood pressure and the like; the ground beetle contains volatile oil and amino acid, has the effects of dissolving thrombus, reducing blood fat, promoting bone fracture healing, protecting liver, resisting tumor and the like; the clove contains various substances such as eugenol and the like, and has the effects of resisting bacteria and fungi, expelling parasites, invigorating stomach, relieving pain, detoxifying and the like; the radix seu folium Jasmini Lanceolatae contains oleanolic acid, and has hemostatic, analgesic, pathogenic wind expelling, and dampness removing effects; the corydalis tuber contains various alkaloids, has obvious effects of easing pain and tranquilizing, and has certain effects of relieving fever and cooling.
In traditional Chinese medicine, the hyperosteogeny is generally considered to be caused by deficiency of vital qi of a human body, deficiency of spleen and kidney, and deficiency of wind, cold and damp evil; or injury of waist due to sudden fall, contusion, overstrain, injury of channels, and obstruction of qi and blood. In the traditional Chinese medicine composition, the raw medicinal materials are mutually combined and matched, the synergistic effect is realized, and the cinnamon and the clove are mutually matched, so that the effects of nourishing and tonifying spleen and kidney, and tonifying fire and supporting yang are achieved; the clematis root, the notopterygium root, the radix angelicae pubescentis, the asarum, the evodia rutaecarpa and the pepper are matched to play roles in dispelling wind and removing dampness, warming the middle-jiao and dispelling cold; and the rhizoma drynariae, the ground beetle, the radix sileris and the rhizoma corydalis are matched to play roles in activating blood circulation, dissipating blood stasis and strengthening muscles and bones. Meanwhile, the raw medicinal materials contain various effective components which can play a role in resisting inflammation, easing pain, resisting bacteria and detoxifying, can effectively play a role in relieving and treating diseases such as hyperosteogeny pain and arthritis, and has an excellent treatment effect.
The preparation method comprises the steps of firstly crushing and sieving the clematis root, the drynaria rhizome, the notopterygium root, the heracleum hemsleyanum michaux, the asarum, the evodia rutaecarpa, the pepper, the cinnamon, the ground beeltle, the clove, the anemone broussuriensis and the corydalis tuber, and controlling the particle size of the crushed medicine so that the particle size is not too large or too small, thereby facilitating the subsequent extraction of beneficial components in the medicinal materials and being beneficial to the full utilization of the medicine. Then the crushed medicine is added with water for decoction, and the effective components in the raw medicinal materials are extracted by decoction, so that the effective components in the medicine can better exert respective effects, and the medicine is more beneficial to treatment and use. Then the filtered decoction is concentrated and dried to obtain an extract, the extract is mixed with the medicine residues, white vinegar or white spirit is added, the mixture is stirred and mixed into a thick paste, and then the finished product medicine is prepared.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating hyperosteogeny is characterized by comprising the following raw materials in parts by weight: 20-45 parts of clematis root, 20-45 parts of drynaria rhizome, 20-45 parts of notopterygium root, 20-45 parts of radix angelicae pubescentis, 8-12 parts of asarum, 8-15 parts of fructus evodiae, 8-15 parts of pepper, 8-15 parts of cinnamon, 20-45 parts of ground beeltle, 8-15 parts of clove, 20-45 parts of anemone rivularis and 20-45 parts of corydalis tuber.
2. The traditional Chinese medicine composition for treating hyperosteogeny according to claim 1, wherein the dosage of each raw material is respectively as follows according to the parts by weight: 30 parts of clematis root, 30 parts of drynaria rhizome, 30 parts of notopterygium root, 30 parts of pubescent angelica root, 10 parts of asarum, 10 parts of evodia rutaecarpa, 10 parts of pepper, 10 parts of cinnamon, 30 parts of ground beetle, 10 parts of clove, 30 parts of radix sileris and 30 parts of corydalis tuber.
3. The traditional Chinese medicine composition for treating hyperosteogeny according to claim 1, wherein the raw materials further comprise white vinegar or white spirit, and the weight percentage of the white vinegar or white spirit is 20-50%.
4. The traditional Chinese medicine composition for treating hyperosteogeny according to claim 1, wherein centipede is used for replacing the ground beetle in the raw material components.
5. A method for preparing the Chinese medicinal composition for treating hyperosteogeny according to any one of claims 1 to 4, comprising the steps of: pulverizing and sieving radix Clematidis, rhizoma Drynariae, Notopterygii rhizoma, radix Angelicae Pubescentis, herba asari, fructus evodiae, fructus Zanthoxyli, cortex Cinnamomi, Eupolyphaga Seu Steleophaga, flos Caryophylli, radix seu folium Jasmini Lanceolatae, and rhizoma corydalis, respectively, decocting in water twice, and filtering to obtain decoction and residue; concentrating and drying the decoction to obtain extract; mixing the extract and the residue, adding white vinegar or Chinese liquor, stirring, and mixing to obtain the final product.
6. The method for preparing a Chinese medicinal composition for treating hyperosteogeny according to claim 5, wherein 10 times of water is added for each decoction for 2 hours.
7. The method for preparing a Chinese medicinal composition for treating hyperosteogeny according to claim 5, wherein the decoction is concentrated to a relative density of 1.10-1.20, and then spray-dried.
8. The method for preparing a Chinese medicinal composition for treating hyperosteogeny according to claim 7, wherein said spray drying is performed at an inlet air temperature of 150 ℃.
9. The method for preparing a Chinese medicinal composition for treating hyperosteogeny according to claim 5, wherein the mesh size of said sieve is 40 meshes.
10. The method for preparing a Chinese medicinal composition for treating hyperosteogeny according to claim 5, wherein the extract is mixed with the dregs at 60 ℃, and then white vinegar or spirit is added and mixed by stirring.
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