CN113876694A

CN113876694A - Plaster for arthralgia and preparation method thereof

Info

Publication number: CN113876694A
Application number: CN202111277668.7A
Authority: CN
Inventors: 张同良
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-29
Filing date: 2021-10-29
Publication date: 2022-01-04

Abstract

The invention provides a plaster for treating arthralgia and a preparation method thereof, and relates to the technical field of medicine preparation. The Chinese medicinal composition comprises Notoginseng radix, flos Caryophylli, herba asari, radix Clematidis, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, radix Piperis Longi, Os Draconis, Borneolum Syntheticum, sanguis Draxonis, semen Impatientis, fructus Zanthoxyli, radix Aconiti and radix Aconiti Kusnezoffii. The traditional Chinese medicine composition can effectively treat symptoms such as limb soreness, cervical vertebra pain, stiffness, lumbar vertebra stabbing pain and the like, and has good treatment effect and quick curative effect. The preparation method extracts the effective components of part of the raw materials by an alcohol extraction method, and then mixes the effective components with the rest of the raw materials, so that the raw materials can better exert the drug effect, enhance the curative effect and improve the treatment effect.

Description

Plaster for arthralgia and preparation method thereof

Technical Field

The invention relates to the technical field of medicine preparation, in particular to a plaster for treating arthralgia and a preparation method thereof.

Background

Arthralgia, i.e. obstruction of qi and obstruction of qi. Arthralgia syndrome refers to a syndrome of aching pain, numbness, heaviness, difficulty in flexion and extension of the joints and muscles, or even swelling and burning of the joints caused by wind, cold, dampness, heat, etc. on the body's exterior surface and meridians. Clinically, it has progressive or recurrent features. The main pathogenesis is the obstruction of qi and blood and the loss of nourishment of tendons, vessels and joints. This disease is related to the pathogenic wind, cold, dampness and heat, and the deficiency of healthy qi. Pathogenic wind, cold, dampness and other pathogenic factors can easily invade the body to cause diseases when the defensive qi of the body is weak. Sweating when it comes into the wind, wet land in sitting or lying, and rain and wind-related invasion of pathogenic wind, cold and dampness into the meridians and collaterals of the body, which remain in the joints, can cause obstruction of qi and blood in the meridians, and pain due to obstruction, as in Su Wen Bi Lun: wind-cold-dampness leading to qi deficiency is combined to be arthralgia. According to the relative mild or severe feeling of pathogenic qi, it is often classified into migratory arthralgia (wind arthralgia), painful arthralgia (arthralgia due to cold), and migratory arthralgia (arthralgia due to dampness). If the body is deficient in yang or fire is hyperactivity due to yin deficiency, it is complicated by wind-cold-dampness, and the pathogenic heat is transformed into heat or invaded by heat, leaving the joints, it is heat arthralgia. In a word, pathogenic wind, cold, dampness and heat invade the body and obstruct the joints, muscles and tendons, resulting in the blockage of qi and blood and the failure of nourishing the muscles, vessels and joints to cause the disease.

The existing medicine has unsatisfactory curative effect on arthralgia and long treatment time.

Disclosure of Invention

The invention aims to provide a plaster for treating arthralgia, which can effectively treat symptoms such as limb soreness, cervical vertebra pain and stiffness, arm bending and stretching difficulty, lumbar spine stabbing pain and the like, and has good treatment effect and quick curative effect.

The invention also aims to provide a preparation method of the plaster for treating arthralgia, which extracts the effective components of part of raw materials by an alcohol extraction method, and then mixes the effective components with the rest of raw materials, so that the raw materials can better exert the drug effect, enhance the curative effect and improve the treatment effect.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The invention provides a plaster for treating arthralgia, which comprises the following raw materials in parts by weight: 25-35 parts of pseudo-ginseng, 2-7 parts of clove, 3-8 parts of asarum, 10-20 parts of radix clematidis, 10-20 parts of semen brassicae, 12-18 parts of camellia japonica, 5-15 parts of radix angelicae, 6-12 parts of long pepper root, 20-30 parts of keel, 0.5-4 parts of borneol, 0.1-3 parts of dragon's blood, 4-10 parts of semen Impatientis, 1-7 parts of pepper, 8-16 parts of radix aconiti and 7-15 parts of radix aconiti agrestis.

The invention provides a preparation method of a plaster for arthralgia, which comprises the following steps:

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 60-70 deg.C for 20-40min, pulverizing, sieving with 60-80 mesh sieve to obtain fine powder, adding 75-85% volume fraction ethanol into the fine powder, and reflux-extracting at 50-60 deg.C for 30-40min to obtain extractive solution; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding the extractive solution into the micropowder, stirring for 10-20min, and concentrating to obtain extract with relative density of 1.15-1.85.

The plaster for arthralgia and the preparation method of the plaster for arthromyodynia provided by the embodiment of the invention have the following beneficial effects that:

in the invention, the panax notoginseng has the effects of removing blood stasis, stopping bleeding, reducing swelling and relieving pain, and the ginsenoside Rb of the panax notoginseng has an inhibiting effect on central nerves, can effectively relieve pain and has a good sedative effect; the herba asari has effects of dispelling pathogenic wind, dispelling cold, inducing resuscitation, relieving pain, inhibiting arthritis, relieving inflammation, and tranquilizing mind. The pseudo-ginseng and the asarum are used in combination, so that the syndrome of pathogenic wind-cold-dampness of the body can be effectively improved, qi and blood of the body are smooth, the purposes of relieving swelling and pain are achieved, and the effects are mutually promoted, so that the medicine effect is better. The clematis root has the effects of dispelling wind and removing dampness, and dredging collaterals and relieving pain, and is matched with the asarum to supplement the effects of dispelling wind and removing cold and removing dampness, thereby enhancing the effects of relieving pain and stopping pain. The white mustard seed can promote qi and dry phlegm, dissipate stagnation and relieve swelling, the camellia can warm the middle-jiao and resolve dampness, promote qi circulation and relieve pain, and the dahurian angelica root can relieve exterior syndrome and dispel cold, expel wind and relieve pain, relieve swelling and expel pus, and after the three are combined, pathogenic qi such as cold and dampness of an organism can be effectively improved, and the blockage condition of channels of the organism can be relieved, so that the symptoms of aching, numbness and bending and stretching of joints and muscles of limbs can be obviously improved, and the aim of treating arthralgia is fulfilled. The long pepper root has the effects of dispersing qi, relieving pain, eliminating dampness and relieving swelling, and the borneol has the effects of clearing heat and relieving pain, and the compatibility of the long pepper root and the borneol can clear heat, warm and dredge channels while dispersing qi, dispelling cold, so that the drug effect of the drug can better act on an organism, the drug effect can better permeate into skin, the pathological change part can be treated, and the drug effect can be improved. The dragon's blood has the effects of removing blood stasis and relieving pain, the pepper has the effects of warming middle-jiao and relieving pain, the monkshood has the effects of dispelling wind and removing dampness and warming channels and relieving pain, and the kusnezoff monkshood root has the effects of dispelling wind and removing dampness and dispelling cold and relieving pain. Flos Caryophylli has effects of warming middle-jiao, lowering adverse qi, invigorating kidney, and tonifying yang, and Os Draconis has effects of relieving mental uneasiness, suppressing hyperactive liver, and subsiding yang, and the two can complement with other raw materials, and can further enhance drug effect. The raw materials are reasonable in proportion, the effects complement each other, and the drug effect of the drug is more conveniently exerted, so that the drug has a better treatment effect and is quicker in drug effect.

In the invention, the effective components are extracted from part of the raw materials by an alcohol extraction method, so that the extraction rate of the effective components can be improved, and the utilization rate of the raw materials can be increased. The other part of raw materials are directly ground into powder and mixed with the extracting solution obtained by the alcohol extraction method, so that the raw materials can be better utilized after treatment, the drug effect of the raw materials can be better exerted, the curative effect is enhanced, and the treatment effect is improved.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

A plaster for treating arthralgia comprises the following raw materials in parts by weight: 25-35 parts of pseudo-ginseng, 2-7 parts of clove, 3-8 parts of asarum, 10-20 parts of radix clematidis, 10-20 parts of semen brassicae, 12-18 parts of camellia japonica, 5-15 parts of radix angelicae, 6-12 parts of long pepper root, 20-30 parts of keel, 0.5-4 parts of borneol, 0.1-3 parts of dragon's blood, 4-10 parts of semen Impatientis, 1-7 parts of pepper, 8-16 parts of radix aconiti and 7-15 parts of radix aconiti agrestis.

Pseudo-ginseng, with warm nature, sweet and slightly bitter taste, enters liver and stomach meridians, and has the actions of removing blood stasis, stopping bleeding, relieving swelling and alleviating pain, which belongs to the category of hemostatics. It is used to treat hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain. The ginsenoside Rb of Notoginseng radix has effects of inhibiting central nerve, Notoginseng radix total saponin can inhibit blood platelet aggregation, and Notoginseng radix extract has effects of tonifying heart, lowering blood pressure, protecting liver, relieving inflammation, reducing blood cholesterol, regulating immunity and resisting virus. In general, it has hemostatic, platelet aggregation and thrombolysis, hemolytic, hematopoietic effects on blood and hematopoietic system; has effects in resisting arrhythmia, atherosclerosis, anoxia, shock, and cerebral ischemia for cardiovascular system; has effects of inhibiting central nerve and relieving pain; it has effects in enhancing immunity, protecting liver function, resisting tumor, delaying aging, lowering blood sugar, relieving inflammation, regulating metabolism, and promoting growth; has low toxicity and basically no side effect after long-term administration.

Clove, warm and pungent, enters spleen, stomach, lung and kidney meridians, warms middle energizer to descend adverse qi, tonifies kidney to strengthen yang, and is used for spleen and stomach deficiency cold, hiccup vomiting, anorexia, vomiting and diarrhea, psychroalgia of heart and abdomen, impotence due to kidney deficiency. The clove contains volatile oil, and the oil mainly contains syringic acid, acetyl syringic acid, caryophyllene, methyl n-pentanone, methyl n-heptanone, vanillin and other components. Has antibacterial and anthelmintic effects, and can be used as aromatic, spasmolytic and expelling pathogenic wind agent for treating gastropathy, abdominal pain, emesis, neuralgia, toothache, etc.

Asarum herb, herba asari, warm in nature and pungent in flavor, enters heart, lung and kidney meridians, dispels wind, dispels cold, clears orifices and relieves pain, warms lung and eliminates phlegm, belongs to the pungent and warm exterior-resolving herbs classified under exterior-resolving herbs, and is used for treating wind-cold type common cold, headache, toothache, nasal obstruction, nasosinusitis, rheumatic arthralgia, phlegm retention, asthma and cough. Has local anesthetic effect, has a certain degree of inhibition effect on arthritis, also has a certain bacteriostatic effect, and has the effects of enhancing lipid metabolism, increasing blood sugar and regulating organism smooth muscle function. The volatile oil can lower blood pressure of anesthetized animals, and the decoction can raise blood pressure; and has anti-inflammatory and anticonvulsive effects. Also has analgesic, tranquilizing, fever inhibiting, antipyretic, antihistaminic, antiallergic, and respiratory exciting effects. Contains volatile oil, and major components such as methyl eugenol, eugenone, and asarinin.

Clematis chinensis, warm in nature, pungent and salty in flavor, enters bladder meridian, dispels wind and dampness, and unblocks collaterals to relieve pain, and belongs to wind-damp-dispelling and cold-dispersing herbs classified under wind-damp-dispelling diseases. It is indicated for wind-damp arthralgia, numbness of limbs, spasm of tendons and vessels, difficulty in flexion and extension, bone sticking throat. Has effects in relieving pain, resisting malaria, lowering blood sugar, promoting bile flow, improving esophageal peristalsis, softening fishbone, and relaxing throat, esophagus and smooth intestinal muscle. Has rhythm or relaxation enhancing effect on smooth muscle, and has analgesic, choleretic, labor inducing, antimicrobial, diuretic, and blood pressure lowering effects. Mainly contains oleanolic acid, hederagenin, etc.

White mustard seed, semen brassicae, with warm nature and pungent taste, enters lung channel and stomach channel, induces qi and dry phlegm, dissipates stagnation and reduces swelling, and belongs to the diuresis-inducing and edema-relieving herbs classified under the diuresis-inducing and dampness-excreting herbs. It can be used for treating cough, asthma, excessive phlegm, chest fullness, hypochondriac pain, numbness of limbs, arthralgia, damp phlegm, abscess, dorsal furuncle, and toxic swelling.

Camellia japonica is pungent, bitter and cold, and has the effects of astringing, cooling blood and stopping bleeding. Can be used for treating hematemesis, epistaxis, hematochezia, and metrorrhagia; it is used externally to treat burns, scalds and traumatic hemorrhage. The flos Camelliae Japonicae contains astringent hemostatic agents such as anthocyanin and anthocyanin, has effects of stopping bleeding, removing blood stasis and relieving swelling, and can be used for treating hemoptysis, epistaxis, intestine and stomach bleeding, metrorrhagia, burn, scald, traumatic injury, traumatic hemorrhage, etc. The tea flower glutinous rice porridge is added when wine is soaked into the tea flower wine or the glutinous rice porridge is cooked to treat dysentery. The flos Camelliae Japonicae has high medicinal value, and has effects of astringing, stopping bleeding, cooling blood, regulating stomach, regulating qi-flowing, removing blood stasis, and relieving swelling.

The angelica dahurica has pungent taste and warm nature, enters lung, spleen and stomach channels, relieves exterior syndrome, dispels cold, dispels wind, relieves pain, clears nasal orifices, eliminates dampness, stops leucorrhea, reduces swelling, expels pus, dispels wind and relieves itching. It can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, leukorrhagia, sore, carbuncle, and toxic swelling. Contains volatile oil, and also contains Bikeyiangelicin, Xinbikei, dahurian angelica ether, angelicin and the like.

The long pepper root is originated from heat generation, disperses qi and relieves pain, eliminates dampness and detumescence, eliminates cold and inflammation, supplements stomach and increases appetite, and is mainly used for treating damp-cold or mucus diseases, marrow arthralgia, small joint pain, arthritis and swelling, intestinal deficiency and rectocele, stomach deficiency and anorexia and dyspepsia. The root contains piperine, piperlonguminine and piperlonguminine.

The dragon's bone has mild nature, astringent and sweet taste, enters heart channel, liver channel, kidney channel and large intestine channel, has the effects of calming heart and tranquilizing mind, calming liver and suppressing yang hyperactivity, and is mainly used for treating palpitation, insomnia, amnesia, epilepsy, mania, dizziness, spontaneous perspiration, night sweat, spermatorrhea, enuresis, metrorrhagia, leukorrhagia, chronic diarrhea, chronic dysentery, ulcer, unhealed wound and eczema. The main components are calcium carbonate and calcium phosphate.

Borneol is cold in nature, pungent and bitter in taste, enters heart channel, spleen channel and lung channel, induces resuscitation, clears heat and relieves pain, and belongs to a medicine for inducing resuscitation. Can inhibit central nervous system, has obvious sedative and analgesic effects, and can promote growth and division of glial cells; has antiinflammatory, antibacterial, and antifertility effects. The local application has slight stimulation effect on sensory nerves and has certain analgesic and antiseptic effects; after being taken, the medicine can rapidly enter the nerve center through the blood brain barrier to play a role; the sleep time of the mouse caused by the pentobarbital can be obviously prolonged to generate a synergistic effect with the pentobarbital, and the hypoxia tolerance time of the mouse can be prolonged; borneolum Syntheticum (0.5%) with high concentration has inhibitory effect on various bacteria.

Xue Jie, neutral in nature, sweet and salty in flavor, enters heart and liver meridians, and can dispel blood stasis, relieve pain, stop bleeding and promote granulation, so it is indicated for traumatic injury, internal injury, pain due to blood stasis and traumatic hemorrhage. Has antiinflammatory, antibacterial, and antithrombotic effects, and can affect cyclic nucleotide and fibrinolytic activity. Contains red resin over 90% and is the compound of resina Draconis tannin, benzoic acid and benzoylacetic acid.

Semen Impatientis, warm in nature, slightly bitter and pungent in taste, enters lung meridian and liver meridian, breaks blood, softens hard mass, and eliminates food stagnation, and can be used for treating abdominal mass, amenorrhea and dysphagia; grind into powder for external use, blow throat, apply on teeth, mix or decoct into paste.

The Chinese prickly ash is pungent in taste and warm in nature, enters spleen, stomach and kidney channels, warms middle energizer to relieve pain, kills parasites to relieve itching, and is used for treating abdominal psychroalgia, vomiting and diarrhea, and abdominal pain due to parasitic infestation; external use: eczema, pruritus vulvae.

Sichuan aconite root, radix Aconiti, with pungent and bitter taste and strong toxicity, enters heart, liver, kidney and spleen meridians, and has the actions of dispelling wind and removing dampness, warming meridians and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving. Anti-inflammatory and analgesic effects; reducing blood sugar; resisting cancer; strengthening the heart; local anesthesia, etc. The root tuber (mother root) contains aconitine, hypaconitine, mesaconine, lappaconitine, radix Aconiti Szechenyiani, isotaladine, talamine, racemic demethyl eupatorine, uracil, and aconite polysaccharide A, B, C, D.

The kusnezoff monkshood root is hot in nature, pungent and bitter in taste and has strong toxicity, enters heart channel, liver channel, kidney channel and spleen channel, dispels wind, removes dampness, dispels cold and relieves pain, and is orally taken to treat anemofrigid-damp arthralgia, limb joint psychroalgia and heart and abdomen psychroalgia. Has antiinflammatory and analgesic effects; can enhance the effect of epinephrine on cardiac muscle, resist T wave inversion caused by calcium chloride, resist initial S-T section rising and subsequent S-T section falling caused by hypophysin; it also has effects in enhancing toxicity of ouabain G to myocardium, resisting histamine, and locally anesthetizing. The product mainly contains chemical components such as virulent diester alkaloids, including aconitine, hypaconitine, neoaconitine, mesaconine, 3-deoxyaconitine, glauconine, and guanamine.

The panax notoginseng has the effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain, and the ginsenoside Rb of the panax notoginseng has the effect of inhibiting central nerves, can effectively relieve pain and has good calming effect; the herba asari has effects of dispelling pathogenic wind, dispelling cold, inducing resuscitation, relieving pain, inhibiting arthritis, relieving inflammation, and tranquilizing mind. The pseudo-ginseng and the asarum are used in combination, so that the syndrome of pathogenic wind-cold-dampness of the body can be effectively improved, qi and blood of the body are smooth, the purposes of relieving swelling and pain are achieved, and the effects are mutually promoted, so that the medicine effect is better. The clematis root has the effects of dispelling wind and removing dampness, and dredging collaterals and relieving pain, and is matched with the asarum to supplement the effects of dispelling wind and removing cold and removing dampness, thereby enhancing the effects of relieving pain and stopping pain. The white mustard seed can promote qi and dry phlegm, dissipate stagnation and relieve swelling, the camellia can dissipate stasis and relieve swelling and regulate qi, and the dahurian angelica root can relieve exterior syndrome and dispel cold, expel wind and relieve pain, relieve swelling and expel pus, and after the three are combined, pathogenic qi such as cold and dampness of an organism can be effectively improved, and the blockage condition of channels of the organism can be relieved, so that the conditions of aching, numbness and bending and stretching of limbs and joints and muscle are obviously improved, and the aim of treating arthralgia is fulfilled. The long pepper root has the effects of dispersing qi, relieving pain, eliminating dampness and relieving swelling, and the borneol has the effects of clearing heat and relieving pain, and the compatibility of the long pepper root and the borneol can clear heat, warm and dredge channels while dispersing qi, dispelling cold, so that the drug effect of the drug can better act on an organism, the drug effect can better permeate into skin, the pathological change part can be treated, and the drug effect can be improved.

The dragon's blood has the effects of removing blood stasis and relieving pain, the pepper has the effects of warming middle-jiao and relieving pain, the monkshood has the effects of dispelling wind and removing dampness and warming channels and relieving pain, and the kusnezoff monkshood root has the effects of dispelling wind and removing dampness and dispelling cold and relieving pain. Flos Caryophylli has effects of warming middle-jiao, lowering adverse qi, invigorating kidney, and tonifying yang, and Os Draconis has effects of relieving mental uneasiness, calming liver, and suppressing yang hyperactivity, and the two can complement with other raw materials, and has effects of dispelling pathogenic wind and dispelling cold, and further enhancing drug effect. The raw materials are reasonable in proportion, the effects complement each other, and the drug effect of the drug is more conveniently exerted, so that the drug has a better treatment effect and is quicker in drug effect.

A preparation method of a plaster for treating arthralgia comprises the following steps:

In the embodiment, the pseudo-ginseng, the white mustard seed, the kusnezoff monkshood root and other medicinal materials are fried firstly, and the medicinal materials with cold and cool properties are changed into mild medicinal materials by frying, so that the influence on the treatment effect of the arthralgia due to aggravation of cold and dampness evil factors of the part of the arthralgia due to excessive cold and cool medicinal materials is avoided; fry simultaneously and make the hardness that can change the medicinal material, when smashing it, be more convenient for smash the medicinal material, and let the kibbling particle diameter of medicinal material more even, avoid the whole hardness of medicinal material or brittleness inconsistent, partly smash the part and do not have the kibbling condition, and then reduce the medicinal material extravagant. Parching at 60-70 deg.C for 20-40min, under the condition, the modification effect of the medicinal materials is best, and the properties of the medicinal materials can be better mild, and the composition is more suitable for treating arthralgia syndrome caused by obstruction of qi and blood and loss of nourishment of tendons and vessels and joints. The obtained fine powder is sieved by a sieve of 60-80 meshes, so that the uniformity of the obtained fine powder is better, when the effective components are extracted from the fine powder, the effective components can be better extracted, the extraction effect is more consistent, and the effective components are more thoroughly and completely extracted. Ethanol with the volume fraction of 75% -85% is selected for extraction, under the concentration, the ethanol has the best infiltration effect on the fine powder, the ethanol with higher molecular concentration has higher extraction speed on effective components in the fine powder, the extraction is more thorough, and the extraction effect of the effective components is better. Reflux extracting at 50-60 deg.C for 30-40min, with the condition of best extraction effect and highest extraction rate of effective components.

The raw materials such as clove, asarum and the like are ground into micro powder and then mixed with the extracting solution, so that the effective components of the raw materials can be better utilized, and the raw materials are more convenient to exert the drug effect. Stirring for 10-20min to thoroughly mix the micropowder with the extractive solution, improve the uniformity of micropowder in the extractive solution, and promote the effective components of the raw materials. Then concentrating into extract with relative density of 1.15-1.85, so as to improve the concentration of effective components in the extract and further enhance the drug effect of the medicine.

In this example, the mass of ethanol was 8 to 12 times that of the fine powder. Thus ensuring that the ethanol can completely extract the effective components in the fine powder, improving the extraction rate of the effective components and further enhancing the drug effect of the drug.

Reflux extracting for 3 times, reflux extracting at 50-60 deg.C for 30-40min for the first time, filtering to obtain a first reflux extractive solution and a first residue, adding ethanol into the first residue, reflux extracting at 65-75 deg.C for 20-30min for the second time, filtering to obtain a second reflux extractive solution and a second residue, adding ethanol into the second residue, reflux extracting at 80-85 deg.C for 10-20min for the third time, filtering to obtain a third extractive solution, and mixing the first extractive solution, the second extractive solution and the third extractive solution to obtain the extractive solution. The reflux extraction is selected, so that the extraction efficiency can be improved, the extraction rate of effective components can be improved, the extraction time is shortened, and the drug effect of the drug is enhanced. The first reflux extraction is carried out at 50-60 ℃ for 30-40min, the movement speed of ethanol molecules can be increased at the temperature, the infiltration and leaching speed of the ethanol molecules in the fine powder is increased, so that the effective components in the fine powder can be extracted more quickly, and the extraction effect of the effective components is the best at the time. Extracting under reflux at 65-75 deg.C for 20-30min for the second time, extracting the first residue at the temperature to further accelerate the movement of ethanol molecule, and extracting the effective components difficult to extract from the fine powder, specifically extracting ginsenoside in Notoginseng radix and red resin in sanguis Draxonis, which have stable properties and are difficult to extract at low temperature and short time, and preferably extracting the above components by the second extraction. Extracting under reflux at 80-85 deg.C for 10-20min for the third time, wherein alkaloid in radix Aconiti Kusnezoffii and radix Aconiti, specifically aconitine, has stable chemical property, and is difficult to extract at low temperature, and the extraction rate of alkaloid can be further improved by selecting the third extraction, and the concentration of alkaloid in the extractive solution can be increased, so that the drug effect of the drug is better.

Optionally, after the extracting solution is obtained, the method further comprises the steps of concentrating the extracting solution at 70-80 ℃ for 5-10min in vacuum to obtain a concentrated solution, centrifuging the concentrated solution at 800r/min for 5-10min, and adding the separated supernatant into the micro powder. The water content in the extracting solution can be reduced, the concentration of the active ingredients in the extracting solution can be improved, and the drug effect can be enhanced by vacuum concentration of the extracting solution. Vacuum concentrating at 70-80 deg.C for 5-10min, wherein the concentration degree is the best. The concentrated solution is centrifuged, so that impurities in the concentrated solution can be further removed, and the purity of the obtained supernatant is higher; centrifuging at 500-800r/min for 5-10min, with the best centrifugation effect.

Optionally, the step of sieving the micropowder with 90-100 mesh sieve is further included before adding the extract to the micropowder. Therefore, the micro powder with uniform granularity can be obtained, when the extracting solution is added into the micro powder, the dispersion degree of the micro powder in the extracting solution is improved, the micro powder can be more uniformly dispersed in the extracting solution, and the obtained extract has better drug effect. In detail, when the stirring is carried out for 10-20min, the stirring speed is 60-80 r/min. Set up stirring speed, can avoid speed too fast, miropowder and extract mixed effect are not good, stir under this speed, can improve the mixed degree of miropowder and extract.

In the embodiment, before the clove, the long pepper root, the keel and the pepper are ground into micro powder, the clove, the long pepper root, the keel and the pepper are aged for 10-15min at 70-80 ℃. The brittleness of the raw materials can be improved by curing, and the granularity of the micro powder is more uniform during grinding; meanwhile, the medicine property of the raw materials can be milder through curing, the irritation of the raw materials is reduced, and the comfort level in use is improved; the curing effect is best when the mixture is cured for 10-15min at 70-80 ℃. Also comprises coating the extract on non-woven fabric, wherein the thickness of the extract is 1.05-1.75 cm. The thickness of the extract is set, so that the situation that the medicine patch is replaced when the extract is contacted with the skin and the medicine effect of the extract far away from the skin is not fully exerted can be avoided, the utilization degree of the extract is the best under the thickness, and the utilization rate of the extract can be improved.

The plaster has the effects of stopping bleeding, dissipating blood stasis, relieving swelling, relieving pain, warming the middle-jiao and the kidney, expelling wind and cold, expelling wind-damp and dredging the main and collateral channels, opening orifices, dissipating stagnated fire, penetrating bones, expelling wind and dampness, warming the middle-jiao and expelling cold. Can be used for treating arthralgia syndrome, soreness of limbs, and pain of cervical vertebra and lumbar vertebra.

The plaster of the invention can also be used in combination with fumigation and medicinal liquor.

The raw materials for fumigation comprise: 550 parts of 450-piece willow branch, 550 parts of 450-piece mulberry branch, 90-120 parts of willow leaf, 130 parts of 110-piece camphor wood, 70-80 parts of folium artemisiae argyi and 70-80 parts of spina gleditsiae, adding 25-35 jin of water into the raw materials, and decocting for 30-40min to obtain the fumigation liquid.

The application method of the fumigation liquid comprises the following steps: adding the fumigation solution into foot bath barrel, fumigating both hands and feet, covering sheet on both hands and feet, and fumigating for 15-30 min; then soaking the fumigation solution in a towel, and carrying out hot compress on the painful part; washing hair with the fumigation solution two hours after meal. It should be noted that: when the fumigation liquid is used for fumigation or bathing and washing the hair, wind shielding and warm keeping are required, cold and uncooked foods are forbidden, and white boiled water is often drunk.

In the fumigation and washing process, due to the pharmacological action of the traditional Chinese medicines and the hot temperature of the medicines, the capillary vessel dilatation of the whole body is stimulated, the circulation of blood and lymph nodes is promoted, and the metabolism is promoted. After fumigation, sweat is released from pores of the whole body, so that rheumatism and arthritis in the body are discharged out of the body along with the sweat, and the whole body is relaxed and the joints are flexible. In addition, the fumigation solution has the effects of dispelling wind and promoting urination, reducing swelling and relieving pain, dispelling wind and dampness and benefiting joints, clearing heat and detoxicating, reversing qi and blood stagnation, dispelling wind, drawing out toxin and expelling pus, is mainly used for treating general pain, and particularly has the best treatment effect on cervical vertebra and lumbar vertebra pain.

The medicinal liquor comprises the following raw materials: 70-80 parts of angelica, 120-plus 130 parts of caulis spatholobi, 45-55 parts of raw radix aconiti agrestis, 45-60 parts of raw radix aconiti, 25-35 parts of raw rhizoma arisaematis, 70-80 parts of raw pinellia ternate, 45-55 parts of fructus liquidambaris and 90-110 parts of raw radix fibraureae recisae, the raw materials are mixed, 5-7 jin of white spirit with the alcohol content of more than 60 degrees is added, and the mixture is soaked in the wine for 15-20 days, so that the medicinal liquor is obtained.

The application method of the medicinal liquor comprises the following steps: the medicated liquor is applied to the pain part for 2-3 times a day, 10-15mL each time, three days as a treatment course, and massaging for 5-10min after application.

The medicated liquor has effects of dispelling pathogenic wind and eliminating dampness, subsiding swelling and resolving hard mass, dispelling pathogenic wind and dredging collaterals, clearing heat and detoxicating, replenishing blood and promoting blood circulation, and regulating menstruation and relieving pain, and can be used for treating soreness of waist and knees, cervical vertebra, lumbar disc herniation, scapulohumeral periarthritis, ischialgia, arthritis, traumatic injury, varicosis, hemiplegia, etc.

The use method of the cooperation of the three is as follows: the fumigation solution is applied firstly, then the medicinal liquor is applied, and finally the plaster is applied. The fumigation liquid stimulates the capillary vessel expansion of the skin, promotes the circulation of blood and lymph nodes, promotes metabolism, and enables wind, cold and dampness in the body to be discharged out of the body along with sweat, thereby enabling the whole body to be relaxed and the joints to be flexible. The medicated liquor can further promote blood circulation, and make the medicine act on cervical vertebra, lumbar vertebra or limbs better. The plaster further enhances the treatment and improvement of pathological parts on the basis of the above. The three are matched to comprehensively treat, so that the traditional Chinese medicine is easier to overcome stubborn diseases.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

A plaster for treating arthralgia comprises the following raw materials:

25g of pseudo-ginseng, 2g of clove, 3g of asarum, 10g of radix clematidis, 10g of semen brassicae, 12g of camellia, 5g of radix angelicae, 6g of long pepper root, 20g of dragon bone, 0.5g of borneol, 0.1g of dragon blood, 4g of semen aristolochiae, 1g of pepper, 8g of radix aconiti and 7g of radix aconiti agrestis.

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 60 deg.C for 20min, pulverizing, sieving with 60 mesh sieve to obtain fine powder, adding 75% volume fraction ethanol into the fine powder, and reflux-extracting at 50 deg.C for 30min to obtain extractive solution; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding the extractive solution into the micropowder, stirring for 10min, and concentrating to obtain extract with relative density of 1.15.

Example 2

A plaster for treating arthralgia comprises the following raw materials:

35g of pseudo-ginseng, 7g of clove, 8g of asarum, 20g of radix clematidis, 20g of semen brassicae, 18g of camellia, 15g of radix angelicae, 12g of long pepper root, 30g of dragon bone, 4g of borneol, 3g of dragon blood, 10g of garden balsam seed, 7g of pepper, 16g of radix aconiti and 15g of radix aconiti agrestis.

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 70 deg.C for 40min, pulverizing, sieving with 80 mesh sieve to obtain fine powder, adding 85% ethanol, and reflux-extracting at 60 deg.C for 40min to obtain extractive solution; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding the extractive solution into the micropowder, stirring for 20min, and concentrating to obtain extract with relative density of 1.85.

Example 3

A plaster for treating arthralgia comprises the following raw materials:

30g of pseudo-ginseng, 5g of clove, 5g of asarum, 15g of radix clematidis, 15g of semen brassicae, 15g of camellia, 10g of radix angelicae, 5g of long pepper root, 25g of dragon bone, 2g of borneol, 1g of dragon blood, 7g of garden balsam seed, 3g of pepper, 10g of radix aconiti and 10g of radix aconiti agrestis.

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 65 deg.C for 30min, pulverizing, sieving with 70 mesh sieve to obtain fine powder, adding 80% ethanol, and reflux-extracting at 55 deg.C for 35min to obtain extractive solution; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding the extractive solution into the micropowder, stirring for 15min, and concentrating to obtain extract with relative density of 1.45.

Example 4

A plaster for treating arthralgia comprises the following raw materials:

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 62 deg.C for 25min, pulverizing, sieving with 65 mesh sieve to obtain fine powder, adding 78% ethanol, reflux extracting for 3 times, reflux extracting at 55 deg.C for 35min for the first time, filtering to obtain reflux extractive solution I and residue I, adding ethanol into residue I, reflux extracting at 70 deg.C for 22min for the second time, filtering to obtain reflux extractive solution II and residue II, adding ethanol into residue II, reflux extracting at 82 deg.C for 14min for the third time, filtering to obtain extractive solution III, and mixing extractive solutions I, II and III to obtain extractive solution; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding the extractive solution into the micropowder, stirring for 12min, and concentrating to obtain extract with relative density of 1.32.

In this example, the mass of ethanol was 10 times that of the fine powder.

Example 5

A plaster for treating arthralgia comprises the following raw materials:

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 78 deg.C for 35min, pulverizing, sieving with 75 mesh sieve to obtain fine powder, adding 82% ethanol into the fine powder, reflux-extracting for 3 times, reflux-extracting for 35min at 58 deg.C for the first time, filtering to obtain reflux extractive solution I and residue I, adding ethanol into residue I, reflux-extracting for 26min at 72 deg.C for the second time, filtering to obtain reflux extractive solution II and residue II, adding ethanol into residue II, reflux-extracting for 16min at 83 deg.C for the third time, filtering to obtain extractive solution III, mixing extractive solutions I, II and III to obtain extractive solution, and vacuum-concentrating the extractive solution at 72 deg.C for 8min to obtain concentrated solution; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding the concentrated solution into the micropowder, stirring for 16min, and concentrating to obtain extract with relative density of 1.65.

In this example, the mass of ethanol was 12 times that of the fine powder.

Example 6

A plaster for treating arthralgia comprises the following raw materials:

parching Notoginseng radix, semen Sinapis Albae, herba Camelliae Japonicae, radix Angelicae Dahuricae, sanguis Draxonis, semen Impatientis, radix Aconiti and radix Aconiti Kusnezoffii at 77 deg.C for 32min, pulverizing, sieving with 78 mesh sieve to obtain fine powder, adding 84% ethanol, reflux-extracting for 3 times, reflux-extracting for 34min at 56 deg.C for the first time, filtering to obtain reflux extractive solution I and residue I, adding ethanol into residue I, reflux-extracting for 26min at 73 deg.C for the second time, filtering to obtain reflux extractive solution II and residue II, adding ethanol into residue II, reflux-extracting for 13min at 84 deg.C for the third time, filtering to obtain extractive solution III, mixing extractive solutions I, II and III to obtain extractive solution, vacuum-concentrating the extractive solution at 76 deg.C for 9min to obtain concentrated solution, and centrifuging the concentrated solution at 700r/min for 8min to obtain supernatant; grinding flos Caryophylli, herba asari, radix Clematidis, radix Piperis Longi, Os Draconis, Borneolum Syntheticum and fructus Zanthoxyli into micropowder, adding supernatant into the micropowder of 95 mesh, stirring for 12min at 70r/min, concentrating to obtain extract with relative density of 1.78, and coating the extract on non-woven fabric to obtain extract with thickness of 1.55 cm.

In this example, the mass of ethanol was 9 times that of the fine powder. Grinding flos Caryophylli, radix Piperis Longi, Os Draconis and fructus Zanthoxyli into fine powder, and aging at 75 deg.C for 12 min.

1. Clinical trial

60 testers are selected, the age is 45-60 years, the average age is 53.26 years, and the clinical manifestations of the testers are limb soreness, cervical vertebra pain and stiffness, arm bending and stretching difficulty, lumbar spine stabbing pain, difficult turnover and inconvenient walking. The subjects were randomly divided into 6 groups, 6 groups corresponding to the use of the Chinese medicinal composition of examples 1-6. The using method comprises the following steps: one plaster is respectively pasted on the cervical vertebra, the lumbar vertebra and the joints of the four limbs in the morning and evening, and the plaster is continuously used for 30 days. The test results were observed as follows:

TABLE 1 statistical table of results

As can be seen from the table 1, the plaster provided by the embodiment of the invention can effectively improve the symptoms of cervical vertebra pain and stiffness, lumbar vertebra stabbing pain, difficult turning over, limb soreness and the like. Example 6 compared with examples 1-5, example 6 has the best therapeutic effect, specifically example 6 adds a treatment step to the raw materials on the basis of examples 1-5, and makes more thorough use of the active ingredients of the raw materials, so that the plaster has better and faster curative effect.

2. Irritation test

The plasters of example 3 and example 6 were subjected to a skin irritation test, which procedure included: 10 healthy female rabbits are randomly divided into 2 groups, the plaster of the embodiment 3 and the embodiment 6 is correspondingly used in each group, specifically, the buttocks and the belly of the healthy female rabbits are depilated, the size is 2.5cm by 2.5cm, then the plaster is respectively applied to the depilated part, after 3 days, the depilated part of the rabbits is observed, wherein, the erythema and the inflammation are marked by percentage, 100 percent represents that the erythema or the inflammation is very serious, 0 represents that no erythema or inflammation exists, and so on, the concrete results are as follows:

TABLE 2 irritation test results

No irritation: no erythema and inflammation; has irritation: local erythema or inflammation; strong irritation: erythema and inflammation were significant.

As is apparent from Table 2, the patches obtained in examples 3 and 6 were applied to the depilated area of healthy female rabbits for 3 days, and then the depilated area of the rabbits showed little erythema or inflammation. Therefore, it can be seen that the plaster prepared by the present invention has little irritation and can be applied to different sites.

In conclusion, the plaster for treating arthralgia disclosed by the embodiment of the invention can effectively treat symptoms such as limb soreness, cervical vertebra pain and stiffness, arm bending and stretching difficulty, lumbar spine stabbing pain and the like, is reasonable in raw material ratio, complements each other in efficacy, and is more convenient to exert the drug effect of the drug, so that the drug treatment effect is better and the drug effect is faster. According to the preparation method of the plaster for treating arthralgia disclosed by the embodiment of the invention, the effective components are extracted from part of the raw materials by an alcohol extraction method, so that the extraction rate of the effective components can be improved, and the utilization rate of the raw materials can be increased. The other part of raw materials are directly ground into powder and mixed with the extracting solution obtained by the alcohol extraction method, so that the raw materials can be better utilized after treatment, the drug effect of the raw materials can be better exerted, the curative effect is enhanced, and the treatment effect is improved.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. A plaster for treating arthralgia is characterized by comprising the following raw materials in parts by weight: 25-35 parts of pseudo-ginseng, 2-7 parts of clove, 3-8 parts of asarum, 10-20 parts of radix clematidis, 10-20 parts of semen brassicae, 12-18 parts of camellia japonica, 5-15 parts of radix angelicae, 6-12 parts of long pepper root, 20-30 parts of keel, 0.5-4 parts of borneol, 0.1-3 parts of dragon's blood, 4-10 parts of semen Impatientis, 1-7 parts of pepper, 8-16 parts of radix aconiti and 7-15 parts of radix aconiti agrestis.

2. A method for preparing a plaster for arthromyodynia according to claim 1, comprising the steps of:

3. The production method according to claim 2, wherein the mass of the ethanol is 8 to 12 times that of the fine powder.

4. The preparation method according to claim 2, wherein the reflux extraction is performed 3 times, the first reflux extraction is performed at 50-60 ℃ for 30-40min, the filtration is performed to obtain a first reflux extraction solution and a first filter residue, the ethanol is added into the first filter residue, the second reflux extraction is performed at 65-75 ℃ for 20-30min, the filtration is performed to obtain a second reflux extraction solution and a second filter residue, the ethanol is added into the second filter residue, the third reflux extraction is performed at 80-85 ℃ for 10-20min, the filtration is performed to obtain a third extraction solution, and the first extraction solution, the second extraction solution and the third extraction solution are combined to obtain the extraction solution.

5. The method according to claim 2, wherein the extracting solution is obtained by reflux extraction at 50-60 ℃ for 30-40min, and the method further comprises vacuum concentration of the extracting solution at 70-80 ℃ for 5-10min to obtain a concentrated solution.

6. The method as claimed in claim 5, further comprising centrifuging the concentrated solution at 800r/min for 5-10min, and adding the separated supernatant to the fine powder.

7. The method according to claim 2, further comprising sieving the fine powder through a 90-100 mesh sieve before adding the extract to the fine powder.

8. The method according to claim 2, wherein the stirring speed is 60 to 80r/min at 10 to 20min of stirring.

9. The method of claim 2, wherein the step of aging the clove, the long pepper root, the keel and the zanthoxylum bungeanum at 70-80 ℃ for 10-15min is further included before the step of grinding the clove, the long pepper root, the keel and the zanthoxylum bungeanum into the micro powder.

10. The method according to claim 2, further comprising applying the extract to a non-woven fabric, wherein the extract has a thickness of 1.05-1.75 cm.