CN114042033A - Plaster for cervical vertebra and lumbar vertebra and preparation method thereof - Google Patents

Plaster for cervical vertebra and lumbar vertebra and preparation method thereof Download PDF

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CN114042033A
CN114042033A CN202111277055.3A CN202111277055A CN114042033A CN 114042033 A CN114042033 A CN 114042033A CN 202111277055 A CN202111277055 A CN 202111277055A CN 114042033 A CN114042033 A CN 114042033A
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parts
plaster
raw materials
fine powder
effects
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刘庆云
郑春玲
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract

The invention provides a plaster for cervical vertebra and lumbar vertebra and a preparation method thereof, and relates to the technical field of medicine preparation. The plaster for cervical vertebra and lumbar vertebra comprises: semen Strychni, flos Carthami, radix Et rhizoma Rhei, radix Aconiti Kusnezoffii, radix Angelicae sinensis, cortex Eucommiae, rhizoma Chuanxiong, Scorpio, Eupolyphaga Seu Steleophaga, rhizoma Atractylodis Macrocephalae, Olibanum, Myrrha, herba Ephedrae, and Scolopendra. The preparation method of the plaster comprises the following steps: pulverizing the raw materials, sieving with 70-80 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 50-60 deg.C for 48-72 hr, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, and decocting at 60-70 deg.C for 24-48 hr to obtain unguent. The plaster can quickly reduce swelling and relieve pain, has obvious treatment effect on damage of connective tissues and nervous tissues caused by spondylopathy, and has small irritation, quick response and good treatment effect. In the preparation method, the raw materials are reasonably processed, so that the effective components of the raw materials can better play a role, the drug effect of the plaster is further improved, and the curative effect of the plaster is better.

Description

Plaster for cervical vertebra and lumbar vertebra and preparation method thereof
Technical Field
The invention relates to the technical field of medicine preparation, in particular to a plaster for cervical vertebra and lumbar vertebra and a preparation method thereof.
Background
The spondylopathy is that the sclerotin, intervertebral disc, ligament and muscle of the vertebra are affected, and then the spinal cord, spinal nerve, blood vessel and vegetative nerve are pressed and pulled to stimulate, thereby causing complex and various symptoms. The common diseases include cervical spondylosis and lumbar spondylosis; the main symptoms are: failure to stand upright, headache, vertigo, blurred vision, memory loss, soreness of the neck and shoulders, poor appetite, regurgitation, vomiting, weakness of lower limbs, and paralysis in severe cases. Cervical spondylosis is also known as cervical syndrome, is a general name of cervical osteoarthritis, proliferative cervical spondylitis, cervical radicular syndrome and cervical disc herniation, and is a disease based on degenerative pathological changes. Mainly, due to long-term strain of cervical vertebrae, hyperosteogeny, or prolapse of intervertebral disc and ligament thickening, the spinal cord, nerve root or vertebral artery of cervical vertebrae are pressed, and a series of clinical syndromes of dysfunction appear. It is manifested as degeneration of cervical intervertebral disc and a series of secondary pathological changes, such as instability and loosening of vertebral segment; herniation or herniation of the nucleus pulposus; forming bone spurs; ligament hypertrophy, secondary spinal stenosis and the like irritate or press tissues such as adjacent nerve roots, spinal cords, vertebral arteries, cervical sympathetic nerves and the like, and cause a series of symptoms and signs.
The existing plaster for treating spondylopathy can only temporarily relieve pain, but cannot well treat the damage of connective tissues and nervous tissues caused by spondylopathy, so that the treatment of spondylopathy is difficult to cure. Secondly, the irritant components in the existing black plaster directly contact with the skin, so that the skin of a patient is easy to have anaphylactic reaction when in use, and even the sticking face of the black plaster is red, swollen and burst.
Disclosure of Invention
The invention aims to provide a plaster for cervical vertebra and lumbar vertebra, which can quickly reduce swelling and relieve pain, has obvious treatment effect on the damage of connective tissues and nervous tissues caused by spondylopathy, and has small irritation, quick response and good treatment effect.
The invention also aims to provide a preparation method of the plaster for cervical vertebra and lumbar vertebra, which is characterized in that the raw materials are reasonably processed, so that the effective components of the raw materials can better play a role, the drug effect of the plaster is further improved, and the curative effect of the plaster is better.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
The invention provides a plaster for cervical vertebra and lumbar vertebra, which comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 25-35 parts of unprocessed nux vomica, 26-32 parts of safflower, 24-34 parts of rhubarb, 10-20 parts of common monkshood mother root, 12-18 parts of kusnezoff monkshood root, 10-16 parts of Chinese angelica, 13-17 parts of eucommia bark, 12-18 parts of szechuan lovage rhizome, 5-15 parts of scorpion, 6-12 parts of ground beetle, 7-13 parts of largehead atractylodes rhizome, 8-14 parts of frankincense, 7-12 parts of myrrh, 6-15 parts of ephedra herb and 4-8 parts of centipede.
The invention provides a preparation method of a plaster for cervical vertebra and lumbar vertebra, which comprises the following steps:
pulverizing the raw materials, sieving with 70-80 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 50-60 deg.C for 48-72 hr, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, and decocting at 60-70 deg.C for 24-48 hr to obtain unguent.
The plaster for cervical vertebra and lumbar vertebra and the preparation method of the plaster for cervical vertebra and lumbar vertebra provided by the embodiment of the invention have at least the following beneficial effects:
according to the invention, the raw nux vomica has the effects of dredging collaterals, relieving pain, relieving swelling and dissipating stagnation, the frankincense has the effects of regulating qi, activating blood, relieving pain, relieving swelling, and promoting granulation, the myrrh has the effects of activating blood, relieving pain, promoting granulation, dissipating blood stasis, and eliminating stasis, the ephedra has the effects of inducing diuresis, relieving swelling, generating heat and dispelling cold, the raw nux vomica, the frankincense, the myrrh and the ephedra are used in a matching way, and the effects of dredging collaterals, regulating qi and blood of an organism are realized, the blood circulation of the organism is normal, so that blood stasis, nodules and swelling lumps are eliminated, and the cervical vertebra and lumbar pain, the protrusion of intervertebral disc and the like are further treated. Safflower has the effects of promoting blood circulation, regulating menstruation, dissipating blood stasis and relieving pain, rhubarb has the effects of dissipating blood stasis and dredging channels, and the effects of regulating menstruation and dredging channels are more obvious when the safflower is matched with the rhubarb, so that the effects of dissipating blood stasis and dissipating blood stasis are improved, and the treatment effect on ligament hypertrophy and spinal stenosis is improved. The radix aconiti has the effects of dispelling wind and removing dampness and warming channels to relieve pain, the radix aconiti kusnezoffii has the effects of dispelling wind and removing dampness and dispelling cold to relieve pain, the active ingredients of the radix aconiti kusnezoffii are aconitine, and the functions of the aconitine and the aconitine supplement each other, so that the wind and dampness dispelling capability of the plaster can be further improved, and the compression capability of a pathological part on nerves is reduced. The angelica has the effects of enriching blood, activating blood, regulating menstruation and relieving pain, the eucommia bark has the capabilities of tonifying liver and kidney and strengthening tendons and bones, and the eucommia bark are matched to nourish the liver and kidney, strengthen the bones and muscles and improve the immunity of the organism while tonifying qi and blood, so that the capability of the organism for resisting diseases is improved. The ligusticum wallichii has the effects of activating blood and promoting qi circulation, and dispelling wind and relieving pain, the scorpion has the effects of calming endogenous wind and relieving spasm, counteracting toxic substances and dissipating stagnation, and dredging collaterals and relieving pain, the eupolyphaga has the anticoagulation effect, the bighead atractylodes rhizome has the effects of tonifying qi, eliminating dampness and promoting diuresis, the centipede has the effects of dispelling wind and relieving spasm, dredging collaterals and relieving pain, counteracting toxic substances and dissipating stagnation, and the effects of dispelling wind and relieving pain can be further improved by matching the ligusticum wallichii with the centipede. The raw materials are reasonable in proportion, can have a remarkable treatment effect on cervical vertebra and lumbar vertebra pain when being matched and used, and is small in irritation and toxic and side effects.
According to the invention, the raw materials are crushed and added with sesame oil for decoction, so that the effective components of the raw materials can be separated out, the concentration of the effective components in the ointment is improved, the effective components in the raw materials can better play a role, the drug effect of the ointment is improved, and the curative effect of the ointment is better.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 25-35 parts of unprocessed nux vomica, 26-32 parts of safflower, 24-34 parts of rhubarb, 10-20 parts of common monkshood mother root, 12-18 parts of kusnezoff monkshood root, 10-16 parts of Chinese angelica, 13-17 parts of eucommia bark, 12-18 parts of szechuan lovage rhizome, 5-15 parts of scorpion, 6-12 parts of ground beetle, 7-13 parts of largehead atractylodes rhizome, 8-14 parts of frankincense, 7-12 parts of myrrh, 6-15 parts of ephedra herb and 4-8 parts of centipede.
Unprocessed Strychnos nux-vomica is bitter and warm, has great toxicity and enters liver and spleen meridians; dredging collaterals, relieving pain, resolving hard mass and eliminating swelling; can be used for treating rheumatism, numbness, paralysis, traumatic injury, carbuncle, swelling and pain, poliomyelitis sequela, and rheumatoid arthralgia. It excels in resolving hard mass and quickly relieving swelling, and is especially effective in resolving hard mass and relieving swelling when used in combination with Ru Xiang, Mo Yao and Ma Huang.
Safflower, with warm nature and pungent taste, enters heart and liver meridians, activates blood and unblocks meridians, removes stasis and relieves pain, belonging to the category of blood-activating and menstruation-regulating herbs under blood-activating and stasis-resolving herbs. It is indicated for amenorrhea, dysmenorrhea, lochiorrhea, mass, traumatic injury, sore and ulcer with swelling and pain. Has effects in slightly exciting heart, reducing coronary artery resistance, and increasing coronary blood flow and myocardial trophism blood flow; resisting myocardial ischemia, myocardial infarction and arrhythmia; improving peripheral microcirculation disturbance; anticoagulation; reducing blood fat; improving the hypoxia tolerance; exciting the uterus; relieving intestinal spasm; has immunological activity and anti-inflammatory effect; can relieve metabolic disorder of monoamine neuromediators in brain tissue; can cause mutation. Animal experiments show that small dosage of the decoction has an exciting effect on heart, and large dosage of the decoction has an inhibiting effect; has obvious direct contraction effect on blood vessels; the safflower yellow can obviously prolong the survival time of the left lung of the mouse in an anoxic environment; has obvious inhibiting effect on platelet aggregation caused by ADP; has analgesic effect.
Rhubarb, radix et rhizoma Rhei, being cold in nature and bitter in taste, enters spleen channel, stomach channel, large intestine channel, liver channel and pericardium channel, and is a purgative herb classified under purgatives for purging heat and relaxing bowels, cooling blood and removing toxicity, and removing blood stasis and dredging channels. The extract has purgative, antibacterial, hemostatic, bile secretion promoting, blood lipid reducing, blood pressure lowering and antitumor effects, and has catharsis, cholagogue, hepatoprotective, gastric and duodenal ulcer resisting, and intestinal canal smooth muscle exciting effects on digestive system. The purgative component is combined anthraquinone glycoside, and the bacteriostatic component is free anthraquinone.
Sichuan aconite root, radix Aconiti, with heat nature, pungent and bitter taste, has strong toxicity, enters heart, liver, kidney and spleen meridians, dispels wind and dampness, warms meridians to alleviate pain, and belongs to the category of wind-damp-dispelling herbs. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving. Anti-inflammatory and analgesic effects; reducing blood sugar; resisting cancer; strengthening the heart; local anesthesia, etc. The main active component is aconitine.
Wild aconite root, radix Aconiti Kusnezoffii, pungent and bitter in flavor, with strong toxicity, enters heart meridian, liver meridian, kidney meridian and spleen meridian. Expelling wind, removing dampness, dispelling cold and relieving pain, which belongs to the wind-damp-dispelling cold-dispersing medicine classified under the wind-damp-dispelling medicine. The oral administration can be used for treating arthralgia due to wind-cold-dampness, cold pain of limbs and joints, and cold pain of heart and abdomen; it can be applied topically to affected parts or decocted with water for treating carbuncle, cellulitis, and scabies. Has antiinflammatory and analgesic effects; can enhance the effect of epinephrine on cardiac muscle, resist T wave inversion caused by calcium chloride, resist initial S-T section rising and subsequent S-T section falling caused by hypophysin; it also has effects in enhancing toxicity of ouabain G to myocardium, resisting histamine, and locally anesthetizing. The main component is aconitine.
Dang Gui is warm in nature, sweet and pungent in flavor, and enters liver meridian, heart meridian and spleen meridian. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation, which belongs to the category of tonics under deficiency-tonifying herbs. It is used to treat sallow complexion due to blood deficiency, vertigo, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency cold, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, carbuncle, cellulitis, and pyocutaneous disease. The angelica has the effects and functions of reducing platelet aggregation and resisting thrombus; promoting hematopoietic system function; reducing blood lipid and resisting arteriosclerosis; oxidation resistance and free radical scavenging; enhancing immune system function; inhibiting type I, II, III and IV allergy; has bidirectional exciting and inhibiting effects on uterus; inhibiting prostatic hyperplasia; anti-gonadotropin; radiation damage resistance; anti-tumor; anti-inflammatory, analgesic, and anti-injury; protecting liver, promoting bile flow, promoting digestion, and inhibiting gastrointestinal motility; has effects in inhibiting nervous system, relaxing airway smooth muscle, promoting urination, and inhibiting bacteria. Can inhibit uterus of isolated animal and excite uterus of whole animal. Ligustilide has antiasthmatic effect on experimental animals, and has effect in inhibiting central nervous system. The antianemia effect may be related to vitamin B12 and microelements such as iron and zinc.
Du Zhong is warm in nature and sweet in flavor, and enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, prevent abortion, and belong to yang tonics classified under deficiency-tonifying herbs. It is indicated for lumbago due to kidney deficiency, weakness of tendons and bones, bleeding during pregnancy, fetal irritability, and hypertension. Has blood pressure lowering effect; enhancing the immune function of the organism; affecting pituitary-adrenal system function; has inhibitory effect on isolated uterus; has diuretic effect; has obvious analgesic and anti-inflammatory effects. Pharmacological experiments show that the water extract and the alcohol extract of the bark and the leaf have the functions of acute blood pressure reduction and blood vessel dilatation. Contains pinoresinol diglucoside, D-eugenol, eucommia ulmoides glycosides, eucommia ulmoides oliv A, erythro-dihydroxy dehydro-dibastinol, etc.
Chuan Xiong is warm in nature and pungent in flavor, enters liver channel, gallbladder channel and pericardium channel, activates blood and qi, dispels wind and relieves pain, and belongs to the blood-activating and pain-relieving herbs classified under the blood-activating and stasis-resolving herbs. Can be used for treating thoracic obstruction, cardialgia, pricking pain in chest and hypochondrium, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, addictions, abdominal pain, headache, and rheumatalgia. Effects on the cardiovascular and cerebrovascular System: has inhibitory effect on heart; can expand blood vessels and reduce blood pressure; increase coronary flow; has protective effect on myocardial and reperfusion injury; improving microcirculation; improving cerebral circulation and cerebral ischemia. Improving blood system, promoting urination, and enhancing immune system; can inhibit tracheal contraction caused by leukotriene, histamine, and prostaglandin E2; can prevent and protect rat experimental pulmonary edema caused by epinephrine; has antitumor and radioprotective effects. Mainly contains ligustilide, 3-butylidenephthalide and sabinene.
Scorpion, mild in nature, pungent in flavor and toxic in flavor, enters liver meridian, can extinguish wind and relieve spasm, counteract toxic pathogen and dissipate nodulation, unblock collaterals and alleviate pain, and belongs to the wind-extinguishing and spasm-stopping herbs classified under liver-calming and wind-extinguishing herbs. Scorpio can be used for treating infantile convulsion, spasm, apoplexy, facial distortion, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, and lymphoid tuberculosis. The scorpion has certain anticonvulsive and antiepileptic effects; the scorpion preparation has obvious and lasting antihypertensive effect on the intragastric perfusion, intramuscular injection and intravenous injection of dogs; the scorpion decoction or the extract thereof has the effect of reducing blood pressure and has longer lasting effect than the infusion; the cardiovascular system shows positive muscle strength and negative frequency, contracts blood vessels and inhibits thrombosis; inhibiting tumor growth, killing cysticercus cellulosae, paralyzing skeletal muscle, increasing blood sugar, reducing the respiration regulation ratio of brain cell mitochondria, the ratio of adenosine diphosphate to oxygen, oxygen quotient and cytochrome oxidase activity, and increasing oxygen quotient of myocardial cell mitochondria.
The eupolyphaga has the anticoagulation effect, can improve and enhance the blood supply of main organs, tissues and the whole body in vivo, has obvious inhibition effect on the aggregation rate of platelets, can obviously inhibit the induced aggregation of exogenous ADP and the release function of the platelets, and can shorten the time of erythrocyte electrophoresis. The water extract can obviously reduce the oxygen consumption of myocardial cells, the total alkaloids of the Chinese polyphaga can prolong the electrocardio disappearance time of mice, prolong the survival time of the mice in hypoxia caused by increasing oxygen consumption, improve the tolerance of myocardium and brain to ischemia and reduce the oxygen consumption of heart and brain tissues.
Bighead atractylodes rhizome, with warm nature, sweet and bitter taste, enters spleen and stomach meridians, strengthens spleen, supplements qi, eliminates dampness and induces diuresis, stops sweating and prevents abortion, and belongs to qi tonics classified under deficiency-tonifying herbs. It is indicated for spleen and stomach qi deficiency, anorexia, listlessness, qi deficiency, distention, diarrhea, phlegm and fluid retention, edema, jaundice, damp arthralgia, dysuria, dizziness, spontaneous perspiration, and threatened abortion. Has spasmolytic, hepatoprotective, and antibacterial effects. It also has effects in promoting gastrointestinal motility, promoting bile flow, resisting oxidation, lowering blood sugar, resisting blood coagulation, resisting bacteria, dilating blood vessel, inhibiting heart, and tranquilizing mind.
Frankincense, radix astragali. It is indicated for qi and blood stasis, pain in heart and abdomen, carbuncle, sore, swelling and toxin, traumatic injury, rheumatic arthralgia, dysmenorrhea, and puerperal blood stasis and pain. It is also used for treating acute appendicitis. The volatile oil is the effective component of Olibanum for relieving pain, mainly n-octyl acetate with pain relieving effect, and accounts for 92.46% of the total amount of volatile oil.
Myrrh, radix seu folium Parabarii, myrrh, and the like. Chest and abdomen pain due to blood stasis; dysmenorrhea; amenorrhea; (iii) a symptom; traumatic injury; carbuncle, swelling and sore; intestinal abscess; blood-shot eyes with swelling and pain. Can be used for treating traumatic injury, blood stasis, swelling and pain, carbuncle, cellulitis, and pain of chest and abdomen; it is indicated for long-term sore without astringency.
Ephedra, herba Ephedrae, with warm nature, pungent and slightly bitter taste, enters lung meridian and bladder meridian, and is a pungent-warm exterior-releasing herb classified under exterior-releasing herbs for inducing sweat, dispelling cold, dispersing lung qi, relieving asthma, inducing diuresis to alleviate edema. It is used to treat common cold due to wind-cold, chest distress, cough, edema due to wind-cold, and bronchial asthma. Has adrenomimetic nerve effect on cardiovascular system, and the blood pressure increasing effect can generate rapid tolerance; has effects of relieving asthma, relieving cough, and eliminating phlegm; can increase sweat gland secretion; has obvious diuretic effect; has antiallergic and antiinflammatory effects; has antipyretic effect and pathogenic microorganism resisting effect at different degrees; can excite the center and influence the transmission of nerve and muscle. Has effects in promoting cholesterol, reducing blood urea nitrogen, and increasing serum cholesterol. Can excite iris radiating muscle to enlarge pupil; it also can stimulate isolated uterus, and can reduce uterine activity for normal women. Ephedrine generally exhibits inhibition of gastrointestinal secretion. Can cause blood sugar to rise, but has weak and non-constant effect. Can be used for resisting allergy and inhibiting influenza virus; the herba Ephedrae oil emulsion has effects of relieving pain and causing muscle paralysis, and inhibiting Bufo siccus heart; ephedrine can lower blood pressure. Contains various alkaloids, volatile benzyl methylamine, etc. Wherein ephedrine is used as main effective component.
Wu Gong, pungent in flavor, warm in nature, toxic, dispel wind and stop spasm, unblock collaterals and alleviate pain, counteract toxicity and dissipate nodulation. Can promote blood circulation, and relieve swelling, pain and numbness.
The raw nux vomica has the effects of dredging collaterals, relieving pain, relieving swelling and dissipating binds, the frankincense has the effects of regulating qi, activating blood, fixing pain, relieving swelling and promoting granulation, the myrrh has the effects of activating blood, relieving pain, relieving swelling, promoting granulation, dissipating blood, removing blood stasis, the ephedra has the effects of inducing diuresis, relieving swelling, generating heat and dispelling cold, the raw nux vomica, the frankincense, the myrrh and the ephedra are used in a matching way, and the effects of dredging collaterals and regulating qi are realized, so that the channels and collaterals and qi and blood of an organism are smooth, the blood circulation of the organism is normal, blood stasis is removed, nodules and swelling blocks are dispersed, and the cervical vertebra and lumbar pain, the protrusion of intervertebral disc and the like are further treated. Safflower has the effects of promoting blood circulation, regulating menstruation, dissipating blood stasis and relieving pain, rhubarb has the effects of dissipating blood stasis and dredging channels, and the effects of regulating menstruation and dredging channels are more obvious when the safflower is matched with the rhubarb, so that the effects of dissipating blood stasis and dissipating blood stasis are improved, and the treatment effect on ligament hypertrophy and spinal stenosis is improved.
The radix aconiti has the effects of dispelling wind and removing dampness and warming channels to relieve pain, the radix aconiti kusnezoffii has the effects of dispelling wind and removing dampness and dispelling cold to relieve pain, the active ingredients of the radix aconiti kusnezoffii are aconitine, and the functions of the aconitine and the aconitine supplement each other, so that the wind and dampness dispelling capability of the plaster can be further improved, and the compression capability of a pathological part on nerves is reduced. The angelica has the effects of enriching blood, activating blood, regulating menstruation and relieving pain, the eucommia bark has the capabilities of tonifying liver and kidney and strengthening tendons and bones, and the eucommia bark are matched to nourish the liver and kidney, strengthen the bones and muscles and improve the immunity of the organism while tonifying qi and blood, so that the capability of the organism for resisting diseases is improved. The ligusticum wallichii has the effects of activating blood and promoting qi circulation, and dispelling wind and relieving pain, the scorpion has the effects of calming endogenous wind and relieving spasm, counteracting toxic substances and dissipating stagnation, and dredging collaterals and relieving pain, the eupolyphaga has the anticoagulation effect, the bighead atractylodes rhizome has the effects of tonifying qi, eliminating dampness and promoting diuresis, the centipede has the effects of dispelling wind and relieving spasm, dredging collaterals and relieving pain, counteracting toxic substances and dissipating stagnation, and the effects of dispelling wind and relieving pain can be further improved by matching the ligusticum wallichii with the centipede.
Safflower, common monkshood mother root, Chinese angelica, eucommia bark and ephedra have anti-inflammatory effects, and the combined use of the safflower, the common monkshood mother root, the Chinese angelica, the eucommia bark and the ephedra can effectively improve the inflammatory reaction of organisms, reduce the inflammation of the pain parts of lumbar vertebrae and cervical vertebrae and promote the pain-relieving and swelling-reducing effects of the plaster. The raw materials are reasonable in proportion, can have a remarkable treatment effect on cervical vertebra and lumbar vertebra pain when being matched and used, and is small in irritation and toxic and side effects.
The formula also comprises the following auxiliary materials in parts by weight: 50-70 parts of rosin, 55-65 parts of single garlic, 56-66 parts of green Chinese onion, 25-35 parts of folium artemisiae argyi and 57-65 parts of ginger.
Rosin, bitter and sweet in taste and warm in nature, enters liver and spleen channels, and has the effects of dispelling wind and eliminating dampness, expelling pus and drawing out pus, and promoting granulation and relieving pain. Has effects of inhibiting and relieving spasm of gastrointestinal smooth muscle; it also has blood pressure lowering, antitussive, and expectorant effects.
The single garlic has the functions of sterilization and inflammation diminishing, the content of allicin and alliin in the single garlic is high, and the acid enzyme contained in the single garlic can be converted into natural bacteriocin as soon as possible after entering a human body, so the effects of sterilization and inflammation diminishing are obvious, and inflammation can be prevented from being generated in the human body. The Pleione contains abundant prostaglandin, and can accelerate blood circulation disease in human body, clear cholesterol in blood, prevent thrombosis, and maintain cardiovascular health; in addition, the unibract garlic can promote the decomposition and metabolism of fat in human body, prevent the fat from accumulating in the blood of human body and prevent hyperlipemia and obesity. Alliin and allicin in Pleione are natural anticancer components, and can inhibit the activity of ammonium nitrite in human body and prevent ammonium nitrite synthesis, and ammonium nitrite is an important carcinogenic component.
The scallion leaves in the scallion can benefit five internal organs, benefit eyes and treat edema; the Sucus Allii Fistulosi has effects in dispelling blood stasis, relieving epistaxis, and relieving pain, and can be used for treating headache and hemorrhoid, and relieving drug toxicity; the radix Allii Fistulosi can be used for treating dyspepsia, hematochezia, hemorrhoid, swelling and pain; scallion seed can improve eyesight and tonify qi deficiency. The herba Alii Fistulosi can stimulate sweat gland, has effects of inducing sweat, relieving exterior syndrome, promoting digestive juice secretion, and invigorating stomach. The scallion also has strong bactericidal action.
Folium artemisiae argyi is warm in nature, bitter and pungent in taste, enters liver channel, spleen channel and kidney channel, dispels cold to stop pain, warms channel to stop bleeding, and belongs to a channel-warming hemostatic belonging to the category of hemostatic. Has antibacterial effect; can obviously enhance the phagocytic function of reticuloendothelial cells; relieving asthma, relieving cough, and eliminating phlegm; against anaphylactic shock; inhibiting myocardial contraction, resisting blood coagulation and inhibiting platelet aggregation at high strength; the sleep time of the sodium pentobarbital can be obviously prolonged; has the effects of promoting gallbladder function and exciting uterus.
Ginger, rhizoma Zingiberis recens, mild in nature and pungent in flavor, enters lung channel, spleen channel and stomach channel, dispels cold and relieves exterior syndrome, lowers adverse qi and prevents vomiting, resolves phlegm and stops cough, relieves toxicity of fish and crab, and belongs to the category of pungent and warm exterior-releasing herbs under exterior-releasing herbs. Rhizoma Zingiberis recens has tranquilizing and anticonvulsive effects; has antipyretic, analgesic and antiinflammatory effects; relaxing gastrointestinal smooth muscle; antiemetic and anti-motion sickness; exciting the heart, enhancing the atrial contractility and protecting the gastric mucosa; protecting liver and benefiting gallbladder; anti-platelet aggregation; anti-5-hydroxytryptamine, antioxidant, antimicrobial, central exciting, promoting in vivo active substance release, promoting absorption, relieving cough, reducing blood lipid, resisting allergy, inducing and resisting mutagenesis, and inhibiting nitrosamine synthesis. Ginger has no obvious toxicity. The rhizoma Zingiberis recens contains gingerol, alpha-zingiberene, beta-phellandrene, citral, aromatic alcohol, methyl heptenone, nonanal, alpha-borneol, etc., and also contains pungent component gingerol.
The rosin, the single garlic, the green Chinese onion, the folium artemisiae argyi and the ginger are matched for use, the rosin has the effects of expelling pus and drawing out toxin, can effectively relieve the toxicity of the radix aconiti and the radix aconiti agrestis, reduces the irritation and toxicity of the plaster, and is safer to use. The scallion juice can disperse blood stasis, relieve pain and relieve drug toxicity, is matched with rosin, has better detoxifying effect and can further reduce the toxicity of the plaster. The folium artemisiae argyi has the effects of dispelling cold, relieving pain, warming channels and stopping bleeding, the ginger has the effects of dispelling cold, relieving exterior syndrome and calming, the single garlic has the effects of sterilizing and diminishing inflammation, and after the garlic is matched with the garlic, the pain of cervical vertebra and lumbar vertebra caused by cold and cool organism can be further reduced, and the pain of cervical vertebra and lumbar vertebra can be effectively improved. The composition can be used together with raw materials, and has effects in removing toxic substance, relieving pain, removing blood stasis, improving drug effect, and accelerating therapeutic course of plaster.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing the raw materials, sieving with 70-80 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 50-60 deg.C for 48-72 hr, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, and decocting at 60-70 deg.C for 24-48 hr to obtain unguent.
In the embodiment, the volume of the raw materials can be reduced by crushing the raw materials, the raw materials are more easily turned to brown after sesame oil is added into the raw materials, the preparation efficiency of the plaster is improved, and the preparation time of the plaster is shortened. When the raw materials are sieved by a sieve of 70-80 meshes, the treatment effect of the raw materials is best. Decocting at 50-60 deg.C for 48-72h, and frying with oleum Sesami to separate out effective components of the raw materials, so that the effective components can exert drug effect more conveniently. The rosin, the single garlic, the green Chinese onion, the folium artemisiae argyi and the ginger are added into the medicinal oil, so that the toxicity of the medicinal oil can be reduced, the irritation of the medicinal oil can be reduced, the medicinal oil is safer and less irritant in use, and symptoms such as skin allergy of a user can not be caused. Decocting at 60-70 deg.C for 24-48h for oxidizing, polymerizing and thickening oil in the medicinal oil to form beads, increasing the concentration of effective components in unit volume, and enhancing the medicinal effect of the plaster.
In detail, before adding oleum Sesami into the fine powder, adding 5-8 times of ethanol into the fine powder, ultrasonic extracting for 20-30min, concentrating the extractive solution under 1-2MPa for 10-20min, vacuum drying at 50-60 deg.C for 5-10min, pulverizing, sieving, and sieving with 80-90 mesh sieve. The ethanol is added into the fine powder for ultrasonic extraction, so that the ethanol can better extract the active ingredients in the raw materials, the analysis of the active ingredients is more thorough, and the active ingredients can better exert the drug effect. 5-8 times of ethanol is adopted, so that the fine powder can be completely infiltrated by the ethanol, the effective components in the fine powder can be extracted more thoroughly and more quickly, and the extraction effect is best when ultrasonic extraction is carried out for 20-30 min. Concentrating the extractive solution at 1-2MPa for 10-20min to increase the concentration of effective components, and the concentration is most suitable for solid content of the extract. Vacuum drying at 50-60 deg.C for 5-10min to obtain better drying efficiency and effect, and optimal separation water content without deterioration.
In detail, before adding Colophonium, Bulbus Allii Macrostemonis, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, adding water into them, decocting at 50-60 deg.C for 1-2 hr, filtering to obtain multiple decoctions, and adding the multiple decoctions into the medicinal oil. The raw materials are respectively added with water and decocted for 1-2h at 50-60 ℃, so that the active ingredients of the raw materials can be better extracted, the active ingredients can be more conveniently mixed with the active ingredients of other raw materials in the medicinal oil, and the obtained plaster has better uniformity.
In detail, the mass ratio of the sesame oil to the fine powder is (6-10): 1. The proportion is set, so that the fine powder can be completely fried to be brown in color by the sesame oil, and effective ingredients of the raw materials can be better extracted.
Optionally, cooling the ointment at 1-5 deg.C for 10-20min, and coating the ointment on non-woven fabric in an amount of 1.5-2.25g/cm3. Cooling at 1-5 deg.C to further reduce toxicity and irritation of plaster, and cooling for 10-20min to obtain better effect on plaster. Setting the dosage of the ointment to be 1.5-2.25g/cm3The ointment can better play a role, and the phenomenon that the ointment is too thick and part of the ointment is replaced without playing the efficacy can be avoided, so that the using effect of the ointment is reduced.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials:
25g of unprocessed nux vomica, 26g of safflower, 24g of rhubarb, 10g of radix aconiti, 12g of radix aconiti agrestis, 10g of angelica, 13g of eucommia, 12g of ligusticum wallichii, 5g of scorpion, 6g of eupolyphaga, 7g of rhizoma atractylodis macrocephalae, 8g of frankincense, 7g of myrrh, 6g of ephedra herb and 4g of centipede.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing the raw materials, sieving with 70 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 50 deg.C for 48 hr, filtering to obtain medicinal oil, and decocting at 60 deg.C for 24 hr to obtain unguent.
Example 2
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials:
35g of unprocessed nux vomica, 32g of safflower, 34g of rhubarb, 20g of radix aconiti, 18g of radix aconiti agrestis, 16g of angelica, 17g of eucommia, 18g of ligusticum wallichii, 15g of scorpion, 12g of eupolyphaga, 13g of rhizoma atractylodis macrocephalae, 14g of frankincense, 12g of myrrh, 15g of ephedra herb and 8g of centipede.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing the raw materials, sieving with 80 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 60 deg.C for 72 hr, filtering to obtain medicinal oil, and decocting at 70 deg.C for 48 hr to obtain unguent.
Example 3
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials:
30g of unprocessed nux vomica, 30g of safflower, 30g of rhubarb, 15g of radix aconiti agrestis, 15g of angelica, 15g of eucommia, 15g of ligusticum wallichii, 10g of scorpion, 10g of eupolyphaga, 10g of rhizoma atractylodis macrocephalae, 10g of frankincense, 10g of myrrh, 10g of ephedra herb and 5g of centipede.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing the raw materials, sieving with 75 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 55 deg.C for 60 hr, filtering to obtain medicinal oil, and decocting at 65 deg.C for 36 hr to obtain unguent.
Example 4
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials:
30g of unprocessed nux vomica, 30g of safflower, 30g of rhubarb, 15g of radix aconiti agrestis, 15g of angelica, 15g of eucommia, 15g of ligusticum wallichii, 10g of scorpion, 10g of eupolyphaga, 10g of rhizoma atractylodis macrocephalae, 10g of frankincense, 10g of myrrh, 10g of ephedra herb, 5g of centipede, 60g of rosin, 60g of unibract garlic, 60g of green Chinese onion, 30g of folium artemisiae argyi and 60g of ginger.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing the raw materials, sieving with 75 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 55 deg.C for 60 hr, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii Macrostemonis, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, and decocting at 65 deg.C for 36 hr to obtain unguent.
Before adding rosin, single garlic, shallot, folium artemisiae argyi and ginger into the medicinal oil, adding water into the rosin, single garlic, shallot, folium artemisiae argyi and ginger respectively, decocting at 55 ℃ for 1.5h, filtering to obtain a plurality of decoction liquids, and adding the plurality of decoction liquids into the medicinal oil.
Example 5
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials:
30g of unprocessed nux vomica, 30g of safflower, 30g of rhubarb, 15g of radix aconiti agrestis, 15g of angelica, 15g of eucommia, 15g of ligusticum wallichii, 10g of scorpion, 10g of eupolyphaga, 10g of rhizoma atractylodis macrocephalae, 10g of frankincense, 10g of myrrh, 10g of ephedra herb, 5g of centipede, 60g of rosin, 60g of unibract garlic, 60g of green Chinese onion, 30g of folium artemisiae argyi and 60g of ginger.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing the raw materials, sieving with 75 mesh sieve to obtain fine powder, adding 7 times of ethanol into the fine powder, ultrasonic extracting for 25min, sequentially concentrating the extractive solution at 1.8MPa for 15min, vacuum drying at 55 deg.C for 8min, pulverizing and sieving with 85 mesh sieve to obtain medicinal powder, adding sesame oil into the medicinal powder, decocting at 55 deg.C for 72h, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii Macrostemonis, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, and decocting at 65 deg.C for 40h to obtain unguent.
Before adding rosin, single garlic, shallot, folium artemisiae argyi and ginger into the medicinal oil, adding water into the rosin, single garlic, shallot, folium artemisiae argyi and ginger respectively, decocting at 58 ℃ for 1.6h, filtering to obtain a plurality of decoction liquids, and adding the plurality of decoction liquids into the medicinal oil.
The mass ratio of the sesame oil to the fine powder is 6: 1.
Example 6
A plaster for cervical vertebra and lumbar vertebra comprises the following raw materials:
30g of unprocessed nux vomica, 30g of safflower, 30g of rhubarb, 15g of radix aconiti agrestis, 15g of angelica, 15g of eucommia, 15g of ligusticum wallichii, 10g of scorpion, 10g of eupolyphaga, 10g of rhizoma atractylodis macrocephalae, 10g of frankincense, 10g of myrrh, 10g of ephedra herb, 5g of centipede, 60g of rosin, 60g of unibract garlic, 60g of green Chinese onion, 30g of folium artemisiae argyi and 60g of ginger.
A preparation method of a plaster for cervical vertebra and lumbar vertebra comprises the following steps:
pulverizing raw materials, sieving with 75 mesh sieve to obtain fine powder, adding 7 times of ethanol into the fine powder, ultrasonic extracting for 25min, sequentially concentrating the extractive solution at 1.8MPa for 15min, vacuum drying at 55 deg.C for 8min, pulverizing and sieving to obtain powder with mesh number of 85 mesh, adding sesame oil into the powder, decocting at 55 deg.C for 72h, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii Macrostemonis, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, decocting at 65 deg.C for 40h to obtain unguent, cooling at 2 deg.C for 15min, and coating the unguent on non-woven fabric with dosage of 1.85g/cm3。
Before adding rosin, single garlic, shallot, folium artemisiae argyi and ginger into the medicinal oil, adding water into the rosin, single garlic, shallot, folium artemisiae argyi and ginger respectively, decocting at 58 ℃ for 1.6h, filtering to obtain a plurality of decoction liquids, and adding the plurality of decoction liquids into the medicinal oil.
The mass ratio of the sesame oil to the fine powder is 6: 1.
Test results
Clinical data: 100 cases of testers are selected, and the disease history, symptoms, signs and CT scanning of the testers are used for determining diagnosis. Subjects were randomized into treatment and control groups. Wherein 50 cases of the treatment group are treated by adopting the plaster of the invention, and the control group is treated by adopting a control medicament. The treatment group consisted of 50 individuals, 36 males and 14 females, aged 42-56 years, with a mean age of 52.34 years. The control group comprises 50 male cases and 15 female cases, and has a mean age of 44-60 years and a mean age of 54.68 years. The testers all have lumbago, cervical vertebra pain, paravertebral tenderness and lower limb pain, and the positive testers with raised straight legs have different degrees of changes in muscle strength, sensation and tendon reflex.
The treatment method comprises the following steps:
the medicine of the invention is: using the plaster prepared in example 6, the plaster was attached to the cervical pain and the protrusion of intervertebral disc of the subject 2 times a day for 30 consecutive days.
Control drugs: the moxa cervical vertebra plaster (Zhenghutang, cat # zht-acjzt-12) is used for continuously treating the cervical vertebra pain and the intervertebral disc protrusion of the testee for 30 days after being respectively adhered to the cervical vertebra pain and the intervertebral disc protrusion of the testee for 2 times a day.
The evaluation criteria for the treatment effect were scored using the evaluation criteria for the treatment effect of lumbago of the Japanese society of orthopedics (Japanese orthopedics As Association, JOA). Each function is normally rated 29 points, and each function is lost to 0 point.
TABLE 1 evaluation chart of the chief complaints before and after treatment
Figure BDA0003329823950000171
P < 0.05 has significant difference.
As can be seen from the table 1, the plaster provided by the invention can obviously improve the symptoms of lumbago and cervical spondylosis, reduce the occurrence of disorders in daily life, and enable testers to have a better life.
In conclusion, the plaster for cervical vertebra and lumbar vertebra provided by the embodiment of the invention can quickly reduce swelling and relieve pain, has a remarkable treatment effect on damage of connective tissues and nervous tissues caused by spondylopathy, and is small in irritation, quick in effect taking and good in treatment effect. The preparation method of the plaster for cervical vertebra and lumbar vertebra has the advantages that the raw materials are reasonably processed, so that the effective components of the raw materials can better play a role, the drug effect of the plaster is further improved, and the curative effect of the plaster is better.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. A plaster for cervical vertebra and lumbar vertebra is characterized by comprising the following raw materials in parts by weight: 25-35 parts of unprocessed nux vomica, 26-32 parts of safflower, 24-34 parts of rhubarb, 10-20 parts of common monkshood mother root, 12-18 parts of kusnezoff monkshood root, 10-16 parts of Chinese angelica, 13-17 parts of eucommia bark, 12-18 parts of szechuan lovage rhizome, 5-15 parts of scorpion, 6-12 parts of ground beetle, 7-13 parts of largehead atractylodes rhizome, 8-14 parts of frankincense, 7-12 parts of myrrh, 6-15 parts of ephedra herb and 4-8 parts of centipede.
2. The plaster of claim 1, further comprising the following excipients in parts by weight: 50-70 parts of rosin, 55-65 parts of single garlic, 56-66 parts of green Chinese onion, 25-35 parts of folium artemisiae argyi and 57-65 parts of ginger.
3. A method for preparing a plaster for cervical and lumbar vertebrae as claimed in any of claims 1 to 2, comprising the steps of:
pulverizing the raw materials, sieving with 70-80 mesh sieve to obtain fine powder, adding oleum Sesami into the fine powder, decocting at 50-60 deg.C for 48-72 hr, filtering to obtain medicinal oil, adding Colophonium, Bulbus Allii Macrostemonis, herba Alii Fistulosi, folium Artemisiae Argyi and rhizoma Zingiberis recens into the medicinal oil, and decocting at 60-70 deg.C for 24-48 hr to obtain unguent.
4. The preparation method according to claim 3, wherein before the sesame oil is added to the fine powder, the method further comprises adding 5-8 times of ethanol to the fine powder, performing ultrasonic extraction for 20-30min, and sequentially concentrating, drying, pulverizing and sieving the extract.
5. The method according to claim 4, wherein the extract is concentrated at 1-2MPa for 10-20 min.
6. The method according to claim 5, wherein the concentrated extract is dried under vacuum at 50-60 ℃ for 5-10 min.
7. The method according to claim 6, wherein the vacuum drying is followed by pulverizing and sieving with a mesh size of 80 to 90 mesh.
8. The method according to claim 3, wherein before the rosin, the garlic clove, the scallion, the argy wormwood leaf and the ginger are added into the medicinal oil, the method further comprises the steps of adding water into the rosin, the garlic clove, the scallion, the argy wormwood leaf and the ginger respectively, decocting for 1-2h at 50-60 ℃, filtering to obtain a plurality of decoction liquids, and adding the plurality of decoction liquids into the medicinal oil.
9. The preparation method according to claim 3, wherein the mass ratio of the sesame oil to the fine powder is (6-10): 1.
10. The method of claim 3, further comprising cooling the ointment at 1-5 deg.C for 10-20min, and applying the ointment to a non-woven fabric in an amount of 1.5-2.25g/cm3。
CN202111277055.3A 2021-10-29 2021-10-29 Plaster for cervical vertebra and lumbar vertebra and preparation method thereof Withdrawn CN114042033A (en)

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Application publication date: 20220215