CN101623445A - External medicament for treating hyperosteogeny and preparation method - Google Patents

Abstract

The invention discloses an external medicament for treating hyperosteogeny and a preparation method. The external medicament is prepared from the following raw materials according to certain weight ratio: angelica, radix sileris, notopterygium incisium, rhizoma ligustici wallichii, corydalis tuber, safflower, agilawood, costus root, clove, cassia bark, rhizoma drynariae, radix paeoniae rubra, asarum, pinellia and gastrodia tuber. The external medicament prepared through technical studies has the functions of stimulating circulation to end stasis, expelling wind and removing dampness, and clearing heat and detoxication, wherein volatile oil can promote the absorption of active components. The external medicament applied to treating the hyperosteogeny not only achieves quick response, exact and lasting curative effect, difficult recurrence after healing, but also is suitable for popularization and application.

Description

A kind of topical agent for the treatment of hyperosteogeny and preparation method thereof

Technical field

The invention belongs to the Chinese medicine preparation technical field, relate to a kind of Chinese medicine topical agent, be specifically related to a kind of topical agent for the treatment of hyperosteogeny and preparation method thereof.

Technical background

Hyperosteogeny is current very general a kind of difficult disease both at home and abroad, serious harm people's health, the one, the slow time of the course of disease is longer, the 2nd, pain unbearably, the 3rd, do not have good Therapeutic Method.Just, cure the symptoms, not the disease, do not reach the purpose of radical cure with physiotherapys such as acupuncture, massage, iontophoresis, medicine dialysis, magnetic therapy, sealing, tractions, operation probably has sequela again, delays for a long time, and the state of an illness increases the weight of, sharp ache, numb limbs and tense tendons, activity can not be freely.

Hyperosteogeny is by the osteoporosis decalcification, the soft tissue degeneration, in addition by wet outer the invading of wind and cold, machinery work, wound, combined cause such as suffer from a deficiency of the kidney, cause stagnation of QI-blood, multiple abscess caused by damp-phlegm forms arthroncus at last, bony spur, lip sample hypertrophy, and pressuring nerve causes that pain, numbness, activity are not freely.According to the traditional Chinese medical science " pain is then obstructed. general rule is painful " theory, no matter it all is stagnation of QI-blood and causing that pain appears in any position of human body, so hypertrophy that cervical vertebra, lumbar vertebra, knee joint occur, outstanding, narrow, mainly be by suffering from a deficiency of the kidney, osteoporosis, decalcification and other inducement cause stagnation of QI-blood, and multiple abscess caused by damp-phlegm forms rock-hard epiphysis in the course of time attached on the bone.

This sick symptom is divided cervical vertebra, lumbar vertebra, knee joint, heel hypertrophy from the position, from symptom hyperosteogeny is arranged, intervertebral disk hernia, spinal canal stenosis and bony spur.Since the position difference, and symptom is also different, cervical spondylosis symptom occurs and is: the cervical region activity is dumb, and stiff pain can not be rotated, traction shoulder arm upper limb, pain numbness can not be praised, and with dizziness and nausea.Lumbar vertebra is based on pain, fatigue more so, unable to move around very then can not sit and crouch and upright, and the traction hip joint can not bend and stretch stride and amyotrophy to the lower limb pain numbness.By clinical practice for many years, hammer away according to theory of Chinese medical science, is developed a kind of topical agent for the treatment of hyperosteogeny with the pure natural medical material.Its prescription be Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Rhizoma Corydalis etc. in addition the Chinese medicine penetrating agent form.This medicine is with activating blood circulation to dissipate blood stasis, expelling wind and removing dampness, and the effect of heat-clearing and toxic substances removing is good at, and the treatment hyperosteogeny not only reaches rapid-action but also determined curative effect is lasting, and more the back is difficult for recurrence, and should promote the use of.

Summary of the invention

The object of the invention is to provide a kind of topical agent for the treatment of hyperosteogeny and preparation method thereof, to remedy the deficiency of existing medicine.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is the medicine for external use of being made by the following weight Chinese medicinal raw materials:

30～60 parts of 50～90 parts of Radix Angelicae Pubescentiss of 50～90 portions of Rhizoma Et Radix Notopterygiis of 70～160 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis

50～90 parts of 50～90 portions of Lignum Aquilariae Resinatum of 70～160 parts of Flos Carthamis of 50～120 parts of Rhizoma Corydalis of Rhizoma Chuanxiong

50～120 parts of 50～90 parts of Rhizoma Drynariae of 30～60 portions of Cortex Cinnamomis of 30～60 portions of Flos Caryophyllis of the Radix Aucklandiae

50～120 parts in 50～90 parts of Rhizoma Gastrodiaes of 50～90 parts of Rhizoma Pinelliaes of 70～160 parts of Herba Asaris of Radix Paeoniae Rubra

2, each raw material of Chinese medicine weight proportion of the best of the present invention's prescription is:

45 parts of 75 parts of Radix Angelicae Pubescentiss of 75 portions of Rhizoma Et Radix Notopterygiis of 140 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis

75 parts of 75 portions of Lignum Aquilariae Resinatum of 140 parts of Flos Carthamis of 100 parts of Rhizoma Corydalis of Rhizoma Chuanxiong

100 parts of 75 parts of Rhizoma Drynariae of 45 portions of Cortex Cinnamomis of 45 portions of Flos Caryophyllis of the Radix Aucklandiae

100 parts in 75 parts of Rhizoma Gastrodiaes of 75 parts of Rhizoma Pinelliaes of 140 parts of Herba Asaris of Radix Paeoniae Rubra

3, the preparation method of this topical agent is:

(1) will fill a prescription in each medicated powder be broken into coarse powder, standby;

(2) take by weighing Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, fumitory coarse powder by formula proportion,, make solvent, flood after 1～2 day with 70% ethanol according to fluid extract and extractum item percolation (appendix IO) down, percolation slowly, the first liquid of filtering of collection is an amount of, other device preservation; Continue percolation, soluble component is flowed out fully, the continuous liquid of filtering is concentrated in right amount, adds the liquid of just filtering, and mixes, and is concentrated into fluid extract, and is standby;

(3) take by weighing Rhizoma Chuanxiong, Flos Carthami, the Radix Aucklandiae, Flos Caryophylli, each coarse powder of Cortex Cinnamomi by formula proportion, mix,, extract volatile oil and also collect volatile oil with vapor distillation 5～8 hours, behind beta-schardinger dextrin-bag and volatile oil, lyophilization, the clathrate of volatile oil, standby;

(4) take by weighing seven flavors such as all the other Radix Angelicae Pubescentiss, Lignum Aquilariae Resinatum by formula proportion, mix, decoct with water 4 times, decocted 1～2 hour at every turn, merge decocting liquid, filter, filtrate concentrates, and adds ethanol and fully stirs to make and contain the alcohol amount and reach 50～60%, cold preservation is left standstill, the leaching supernatant, decompression recycling ethanol also is condensed into the clear paste that relative density is 1.12-1.17 (70 ℃), and is standby;

(5) fluid extract of diafiltration and water are carried clear paste put cold after, the clathrate that adds volatile oil mixes, and gets Mentholum, Camphora raw material, mixes, behind an amount of dissolve with ethanol, slowly add in the above-mentioned clear paste, the limit edged stirs, and adds an amount of glycerol simultaneously, stir into ointment, make external plaster application agent, promptly.

This topical agent is to be raw material by Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Rhizoma Corydalis, Flos Carthami, Lignum Aquilariae Resinatum, the Radix Aucklandiae, Flos Caryophylli, Cortex Cinnamomi, Rhizoma Drynariae, Radix Paeoniae Rubra, Herba Asari, the Rhizoma Pinelliae, Rhizoma Gastrodiae, and prescription forms according to a certain weight ratio.The topical agent of making through technical study has activating blood circulation to dissipate blood stasis, expelling wind and removing dampness, and the function of heat-clearing and toxic substances removing, wherein volatile oil can promote the absorption of effective ingredient.Use that Drug therapy hyperosteogeny of the present invention not only reaches rapid-action but also determined curative effect is lasting, more the back is difficult for recurrence, and should promote the use of.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1:

Adopt following raw material of Chinese medicine prescription:

Radix Angelicae Sinensis 140 Radix Saposhnikoviae 75g Rhizoma Et Radix Notopterygii 75g Radix Angelicae Pubescentis 45g

Rhizoma Chuanxiong 100g Rhizoma Corydalis 140g Flos Carthami 75g Lignum Aquilariae Resinatum 75g

Radix Aucklandiae 45g Flos Caryophylli 45g Cortex Cinnamomi 75g Rhizoma Drynariae 100g

Radix Paeoniae Rubra 140g Herba Asari 75g Rhizoma Pinelliae 75g Rhizoma Gastrodiae 100g

The preparation method of this topical agent is:

(1) will fill a prescription in each medicated powder be broken into coarse powder, standby;

(2) take by weighing Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, fumitory coarse powder by formula proportion, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 2 days, slowly percolation is collected the about 2500ml of liquid that just filters, and device is preserved in addition; Continue percolation, soluble component is flowed out fully, the continuous liquid of filtering is concentrated into about 4000ml, adds the liquid of just filtering, and mixes, and is concentrated into fluid extract, and is standby;

(3) take by weighing Rhizoma Chuanxiong, Flos Carthami, the Radix Aucklandiae, Flos Caryophylli, each coarse powder of Cortex Cinnamomi by formula proportion, mix,, extract volatile oil and also collect volatile oil with vapor distillation 8 hours, behind beta-schardinger dextrin-bag and volatile oil, lyophilization, the clathrate of volatile oil, standby;

(4) take by weighing seven flavors such as all the other Radix Angelicae Pubescentiss, Lignum Aquilariae Resinatum by formula proportion, mix, decoct with water 4 times, decocted 2 hours at every turn, merge decocting liquid, filter, filtrate concentrates, and adds ethanol and fully stirs to make and contain the alcohol amount and reach 60%, cold preservation is left standstill, the leaching supernatant, decompression recycling ethanol also is condensed into the clear paste that relative density is 1.14 (70 ℃), and is standby;

(5) fluid extract of diafiltration and water are carried clear paste put cold after, the clathrate that adds volatile oil mixes, and get the about 15g of Mentholum, the about 10g of Camphora, mix, behind the 50ml dissolve with ethanol, slowly add in the above-mentioned clear paste, the limit edged stirs, and adds the about 50g of glycerol simultaneously, stirs into ointment, make external plaster application agent, promptly.

Embodiment 2:

Adopt following raw material of Chinese medicine prescription:

Radix Angelicae Sinensis 70g Radix Saposhnikoviae 50g Rhizoma Et Radix Notopterygii 50g Radix Angelicae Pubescentis 30g

Rhizoma Chuanxiong 50g Rhizoma Corydalis 70g Flos Carthami 50g Lignum Aquilariae Resinatum 50g

Radix Aucklandiae 30g Flos Caryophylli 30g Cortex Cinnamomi 50g Rhizoma Drynariae 50g

Radix Paeoniae Rubra 70g Herba Asari 50g Rhizoma Pinelliae 50g Rhizoma Gastrodiae 50g

The preparation method of this topical agent is:

(1) will fill a prescription in each medicated powder be broken into coarse powder, standby;

(2) take by weighing Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, fumitory coarse powder by formula proportion, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 1 day, slowly percolation is collected the about 1500ml of liquid that just filters, and device is preserved in addition; Continue percolation, soluble component is flowed out fully, the continuous liquid of filtering is concentrated into 2000ml, adds the liquid of just filtering, and mixes, and is concentrated into fluid extract, and is standby;

(3) take by weighing Rhizoma Chuanxiong, Flos Carthami, the Radix Aucklandiae, Flos Caryophylli, each coarse powder of Cortex Cinnamomi by formula proportion, mix,, extract volatile oil and also collect volatile oil with vapor distillation 6 hours, behind beta-schardinger dextrin-bag and volatile oil, lyophilization, the clathrate of volatile oil, standby;

(4) take by weighing seven flavors such as all the other Radix Angelicae Pubescentiss, Lignum Aquilariae Resinatum by formula proportion, mix, decoct with water 4 times, decocted 1 hour at every turn, merge decocting liquid, filter, filtrate concentrates, and adds ethanol and fully stirs to make and contain the alcohol amount and reach 50%, cold preservation is left standstill, the leaching supernatant, decompression recycling ethanol also is condensed into the clear paste that relative density is 1.16 (70 ℃), and is standby;

(5) fluid extract of diafiltration and water are carried clear paste put cold after, the clathrate that adds volatile oil mixes, and get the about 9g of Mentholum, the about 6g of Camphora, mix, behind the 20ml dissolve with ethanol, slowly add in the above-mentioned clear paste, the limit edged stirs, and adds the about 20g of glycerol simultaneously, stirs into ointment, make external plaster application agent, promptly.

Claims (3)

1, a kind of topical agent for the treatment of hyperosteogeny is characterized in that this topical agent comprises what unit of weight was made by the following Chinese medicine of part:

30～60 parts of 50～90 parts of Radix Angelicae Pubescentiss of 50～90 portions of Rhizoma Et Radix Notopterygiis of 70～160 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis

50～90 parts of 50～90 portions of Lignum Aquilariae Resinatum of 70～160 parts of Flos Carthamis of 50～120 parts of Rhizoma Corydalis of Rhizoma Chuanxiong

50～120 parts of 50～90 parts of Rhizoma Drynariae of 30～60 portions of Cortex Cinnamomis of 30～60 portions of Flos Caryophyllis of the Radix Aucklandiae

50～120 parts in 50～90 parts of Rhizoma Gastrodiaes of 50～90 parts of Rhizoma Pinelliaes of 70～160 parts of Herba Asaris of Radix Paeoniae Rubra.

2, a kind of topical agent for the treatment of hyperosteogeny as claimed in claim 1 is characterized in that the weight proportion of each Chinese medicinal components is:

45 parts of 75 parts of Radix Angelicae Pubescentiss of 75 portions of Rhizoma Et Radix Notopterygiis of 140 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis

75 parts of 75 portions of Lignum Aquilariae Resinatum of 140 parts of Flos Carthamis of 100 parts of Rhizoma Corydalis of Rhizoma Chuanxiong

100 parts of 75 parts of Rhizoma Drynariae of 45 portions of Cortex Cinnamomis of 45 portions of Flos Caryophyllis of the Radix Aucklandiae

100 parts in 75 parts of Rhizoma Gastrodiaes of 75 parts of Rhizoma Pinelliaes of 140 parts of Herba Asaris of Radix Paeoniae Rubra.

3, as the described a kind of topical agent for the treatment of hyperosteogeny of claim 1-2, it is characterized in that the preparation method of this topical agent is:

(1) will fill a prescription in each medicated powder be broken into coarse powder, standby;

(2) take by weighing Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, fumitory coarse powder by formula proportion,, make solvent, flood after 1～2 day with 70% ethanol according to fluid extract and extractum item percolation (appendix IO) down, percolation slowly, the first liquid of filtering of collection is an amount of, other device preservation; Continue percolation, soluble component is flowed out fully, the continuous liquid of filtering is concentrated in right amount, adds the liquid of just filtering, and mixes, and is concentrated into fluid extract, and is standby;

(3) take by weighing Rhizoma Chuanxiong, Flos Carthami, the Radix Aucklandiae, Flos Caryophylli, each coarse powder of Cortex Cinnamomi by formula proportion, mix,, extract volatile oil and also collect volatile oil with vapor distillation 5～8 hours, behind beta-schardinger dextrin-bag and volatile oil, lyophilization, the clathrate of volatile oil, standby;

(4) take by weighing seven flavors such as all the other Radix Angelicae Pubescentiss, Lignum Aquilariae Resinatum by formula proportion, mix, decoct with water 4 times, decocted 1～2 hour at every turn, merge decocting liquid, filter, filtrate concentrates, and adds ethanol and fully stirs to make and contain the alcohol amount and reach 50～60%, cold preservation is left standstill, the leaching supernatant, decompression recycling ethanol also is condensed into the clear paste that relative density is 1.12-1.17 (70 ℃), and is standby;

(5) fluid extract of diafiltration and water are carried clear paste put cold after, the clathrate that adds volatile oil mixes, and gets Mentholum, Camphora raw material, mixes, behind an amount of dissolve with ethanol, slowly add in the above-mentioned clear paste, the limit edged stirs, and adds an amount of glycerol simultaneously, stir into ointment, make external plaster application agent, promptly.