CN101020023A - Chinese medicine for treating femoral head necrosis - Google Patents
Chinese medicine for treating femoral head necrosis Download PDFInfo
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- CN101020023A CN101020023A CNA200610170815XA CN200610170815A CN101020023A CN 101020023 A CN101020023 A CN 101020023A CN A200610170815X A CNA200610170815X A CN A200610170815XA CN 200610170815 A CN200610170815 A CN 200610170815A CN 101020023 A CN101020023 A CN 101020023A
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- 239000003814 drug Substances 0.000 title claims abstract description 28
- 230000017074 necrotic cell death Effects 0.000 title abstract 3
- 241000005787 Cistanche Species 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims description 14
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 7
- 244000080767 Areca catechu Species 0.000 claims description 7
- 235000006226 Areca catechu Nutrition 0.000 claims description 7
- 241000717739 Boswellia sacra Species 0.000 claims description 7
- 241000218176 Corydalis Species 0.000 claims description 7
- 208000007875 Femur Head Necrosis Diseases 0.000 claims description 7
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 7
- 241001057584 Myrrha Species 0.000 claims description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 7
- 241000180649 Panax notoginseng Species 0.000 claims description 7
- 239000009286 sanguis draxonis Substances 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 6
- 238000005242 forging Methods 0.000 claims description 6
- 241001489978 Eupolyphaga Species 0.000 claims description 5
- 239000004863 Frankincense Substances 0.000 claims description 5
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract 2
- 241001116742 Drynaria Species 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 21
- 210000004369 blood Anatomy 0.000 description 21
- 239000000843 powder Substances 0.000 description 12
- 210000000988 bone and bone Anatomy 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 6
- 208000015813 Familial avascular necrosis of femoral head Diseases 0.000 description 5
- 239000000284 extract Substances 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241001523579 Ostrea Species 0.000 description 2
- 241000545442 Radix Species 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000003113 dilution method Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241001347978 Major minor Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 241000736246 Pyrola Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000002639 hyperbaric oxygen therapy Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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Abstract
The present invention is one kind of Chinese medicine for treating femoral head necrosis and belongs to the field of medicine technology. The material for the Chinese medicine includes prepared rhizome of rehmannia, drynaria rhizome, epimedium, cistanche, astragalus root and other 20 kinds of Chinese medicinal materials. The present invention has the advantages of high curative effect, high safety and low cost, and opens one new way for the non-operation treatment of femoral head necrosis.
Description
Technical field
The invention belongs to medical technical field.
Background technology
Aseptic necrosis of femoral head rises just gradually at global sickness rate in recent years, and the trend of rejuvenation is arranged, to become key subjects in the medical domain.Suffer from this disability and disabling mostly after being ill, had a strong impact on people's orthobiosis and work.Both at home and abroad for the treatment of femur head necrosis, roughly adopt several method at present: the one, operative therapy, as synovectomy, vascular bundle implantation, osteotomy, femoral head replacement etc.; The 2nd, non-invasive conservative treatment, as hyperbaric oxygentherapy, the Gypsum Fibrosum support is fixed, traction braking etc.Its therapy effect is still undesirable, and complication is many.
The research of treatment by Chinese herbs aseptic necrosis of femoral head in recent years is more, but does not still have effective Chinese patent medicine at present.Study that successful clinical efficacy is definite, safety, new Chinese medicine that toxic and side effects is little throws in clinically, solves vast femur head necrosis patient's misery, will obtain favorable economic benefit and social benefit.
Summary of the invention
The objective of the invention is:
A kind of Chinese patent medicine for the treatment of femur head necrosis is provided, can effectively treats aseptic necrosis of femoral head, no wound treatment is painful.
Technical scheme of the present invention is:
Selecting big Radix Rehmanniae Preparata the kidney invigorating the yang aspect of yang and Herba Cistanches, Rhizoma Drynariae, Herba Pyrolae, the kidney invigorating among the present invention for use, filling out marrow, be good for bone is to be principal agent in the side.Os Draconis, Concha Ostreae are the medicine of Liver and kidney blood system, cooperate its power of mending the bone Shujin of above all medicines outstanding especially, assist for principal agent is.Add Radix Salviae Miltiorrhizae again, Radix Notoginseng, Sanguis Draxonis, croceous promoting blood circulation to restore menstrual flow is with blood stasis dispelling, give birth to firewood, close bone (reparation), Olibanum, Myrrha can lead to 12 warps, divide qi and blood circulation promotion and ease pain, cooperate Liver Channel key medicines such as Rhizoma Corydalis, blood stasis can loose, blood closes and can lead to, and the blood pain can be ended Radix Angelicae Sinensis and blood, hemopoietic is enriched blood, and nourishes blood, treating blood disorders, be panacea in the blood, Radix Astragali QI invigorating is the edema caused by disorder of QI principal agent, qi promoting blood production, be stamped the blood of shape, rely invisible gas and give birth to, so Radix Angelicae Sinensis, the Radix Astragali occupies very critical role in we, the promoting the production of body fluid liquid of assistant catechu, then meat is long in this blood life, and then bone profit, pyrolusitum are filled in Tianjin, Pyritum, eupolyphage sece steleophaga can not only removing blood stasis with potent drugsization stagnate, and the energy of unique synthetism (reparation necrotic bone), make Fructus Amomi, the strong usefulness of Pericarpium Citri Reticulatae Viride fragrance, admittedly protect Central Region, collaborative major-minor medicine is set upright and is not loved heresy, blood stasis dispelling is not just being hindered, with one-tenth the teacher of restraining is arranged, that uses Moschus walks to scurry collateral dredging, opens all keys, loose and stop up knot, saturating flesh bone, to go the medicine gesture, through sick institute is also, all medicines share common receipts the kidney invigorating and fill the strong bone of marrow, the nourishing liver and replenishing blood Shujin reaches promoting blood circulation to restore menstrual flow, and removing blood stasis with potent drugs is given birth to firewood, blood stasis can be loose, blood closes can be bitterly, and insufficiency of blood can be bitterly, and the blood pain can be ended.Support then strong so bone gets marrow." bone corruption " can heal (reparation), and muscle gets blood and moistens then and to relax, and function can be answered.
Each crude drug ratio of the present invention is:
Radix Rehmanniae Preparata 5-10, Rhizoma Drynariae 5-10, Herba Epimedii 5-10, Herba Cistanches 5-8, Radix Astragali 5-8, Radix Salviae Miltiorrhizae 5-8, Radix Notoginseng 5-8, Rhizoma Corydalis 5-8, Herba Pyrolae 5-8, Sanguis Draxonis 5-7, Olibanum (processing) 5-6, Myrrha (processing) 5-6, pyrolusitum 4-7, Radix Angelicae Sinensis 4-7, Eupolyphaga Seu Steleophaga 3-5, Cornu Cervi Degelatinatum 4-7, Concha Ostreae 4-7, Os Draconis 4-7, Stigma Croci 1-3, catechu 1-3, Pyritum (forging) 1-3, Fructus Amomi 1-3, Pericarpium Citri Reticulatae Viride 1-3, Cornu Cervi Pantotrichum 0.4-2, Moschus 0.01-0.2.
Each above-mentioned crude drug is weight ratio.
Each crude drug of the present invention is best than being:
Radix Rehmanniae Preparata 37 Rhizoma Drynariae 37 Herba Epimedii 37 Herba Cistanches 27.8 Radixs Astragali 27.8 Radix Salviae Miltiorrhizaes 27.8 Radix Notoginseng 27.8 Rhizoma Corydalis 27.8 Herba Pyrolae 27.8 Sanguis Draxonis, 22.2 Olibanums (processing) 22.2 Myrrhas (processing) 22.2 pyrolusitums 18.5 Radix Angelicae Sinensis 18.5 Eupolyphaga Seu Steleophagas 18.5 Cornu Cervi Degelatinatums 18.5 Concha Ostreaes 18.5 Os Draconis 18.5 Stigma Croci 9.25 catechu, 9.25 Pyritums (forging) 9.25 Fructus Amomis 9.25 Pericarpium Citri Reticulatae Virides 9.25 Cornu Cervi Pantotrichums 5.6 Moschus 0.37.
Each above-mentioned crude drug is weight ratio.
Manufacture method of the present invention is:
1, water extraction:
By decocting with water three times than the Herba Epimedii in the side of getting, the Radix Astragali, Herba Pyrolae, Rhizoma Drynariae, Herba Cistanches, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata eight flavor crude drug, time was respectively 2,2,1 hours, amount of water is respectively 8,6,6 times, gradation filters, merging filtrate, being concentrated into relative concentration is 1.2-1.3 (90-95 ℃), and thick paste carries out drying under reduced pressure, and it is standby to get dry extract.
2, pulverize:
By being broken into more than fine powder 100 orders than the Radix Notoginseng in the side of getting, Rhizoma Corydalis, Sanguis Draxonis, Olibanum (processing), Myrrha (processing), pyrolusitum, Eupolyphaga Seu Steleophaga, Cornu Cervi Degelatinatum, Concha Ostreae, Os Draconis, Stigma Croci, catechu, Pyritum (forging), Fructus Amomi, Pericarpium Citri Reticulatae Viride, Pulveratum Cornu Cervi Pantotrichum;
The dried cream powder that extracts is broken into more than fine powder 100 orders.
3, mixing, packing:
Above-mentioned two kinds of fine powders are mixed, Moschus is added in the fine powder, behind the medicated powder mixing, divide to be filled in the capsule, get finished product with " equivalent dilution method ".
The invention has the beneficial effects as follows:
For the femur head necrosis patient provides the new drug of a kind of cheapness, treatment aseptic necrosis of femoral head efficient, safe, easy to use, example surplus the clinical observation 10000 (have complete statistics, the person of following up a case by regular visits to 2000 surplus example) has obtained satisfied curative effect.Major part has been kept ill body, has recovered function, and the reparation that has is intact, for non-operating medicine treatment aseptic necrosis of femoral head disease has been created a new road.
Simultaneously important preparation is a kind of conventional industries, the economic value added height, and the huge market demand, at the bottom of the production cost, this product is as preparation in the hospital and new drug, surplus the applying clinical 20 year, obtained considerable economic benefit and social benefit.
In addition, this medical instrument has the effect of the kidney invigorating, and caused by liver and kidney deficiency type lumbago and skelalgia patient is also had better therapeutic effect, has potential patient consumer group.
The specific embodiment:
Embodiment 1
1, water extraction:
3.7 kilograms of Herba Epimedii in the side of getting, 2.7 kilograms of the Radixs Astragali, 2.7 kilograms of Herba Pyrolaes, 3.7 kilograms of Rhizoma Drynariae, 2.7 kilograms of Herba Cistanches, 1.8 kilograms of Radix Angelicae Sinensis, 2.7 kilograms of Radix Salviae Miltiorrhizaes, 3.7 kilogram of eight flavor of Radix Rehmanniae Preparata crude drug decoct with water three times, time was respectively 2,2,1 hours, amount of water is respectively 8,6,6 times, gradation filters, merging filtrate, being concentrated into relative concentration is 1.2-1.3 (90-95 ℃), and thick paste carries out drying under reduced pressure, and it is standby to get dry extract.
2, pulverize:
2.7 kilograms of Radix Notoginseng in the side of getting, 2.7 kilograms of Rhizoma Corydalis, 2.2 kilograms of Sanguis Draxonis, 2.2 kilograms of Olibanums (processing), 2.2 kilograms of Myrrhas (processing), 1.8 kilograms of pyrolusitums, 1.8 kilograms of Eupolyphaga Seu Steleophagas, 1.8 kilograms of Cornu Cervi Degelatinatums, 1.8 kilograms of Concha Ostreaes, 1.8 kilograms of Os Draconis, 1.8 kilograms of Stigma Crocis, 1 kilogram in catechu, 1 kilogram of Pyritum (forging), 1 kilogram of Fructus Amomi, 1 kilogram on Pericarpium Citri Reticulatae Viride, Cornu Cervi Pantotrichum are ground into more than fine powder 100 orders for 0.6 kilogram:
The dried cream powder that extracts is broken into more than fine powder 100 orders.
3, mixing, packing:
Above-mentioned two kinds of fine powders are mixed, 0.04 kilogram in Moschus is added in the fine powder, behind the medicated powder mixing, divide to be filled in the capsule, get finished product with " equivalent dilution method ".
Claims (2)
1, a kind of Chinese patent medicine for the treatment of femur head necrosis, each crude drug ratio is: Radix Rehmanniae Preparata 5-10, Rhizoma Drynariae 5-10, Herba Epimedii 5-10, Herba Cistanches 5-8, Radix Astragali 5-8, Radix Salviae Miltiorrhizae 5-8, Radix Notoginseng 5-8, Rhizoma Corydalis 5-8, Herba Pyrolae 5-8, Sanguis Draxonis 5-7, Olibanum (processing) 5-6, Myrrha (processing) 5-6, pyrolusitum 4-7, Radix Angelicae Sinensis 4-7, soil whole worm 3-5, Cornu Cervi Degelatinatum 4-7, Concha Ostreae 4-7, Os Draconis 4-7, Stigma Croci 1-3, catechu 1-3, natural steel (forging) 1-3, Fructus Amomi 1-3, Pericarpium Citri Reticulatae Viride 1-3, Cornu Cervi Pantotrichum 0.4-2, Moschus 0.01-0.2;
Each above-mentioned crude drug is weight ratio.
2, a kind of Chinese patent medicine for the treatment of femur head necrosis according to claim 1, each crude drug ratio is:
Radix Rehmanniae Preparata 37, Rhizoma Drynariae 37, Herba Epimedii 37, Herba Cistanches 27.8, the Radix Astragali 27.8, Radix Salviae Miltiorrhizae 27.8, Radix Notoginseng 27.8, Rhizoma Corydalis 27.8, Herba Pyrolae 27.8, Sanguis Draxonis 22.2, Olibanum (processing) 22.2, Myrrha (processing) 22.2, pyrolusitum 18.5, Radix Angelicae Sinensis 18.5, Eupolyphaga Seu Steleophaga 18.5, Cornu Cervi Degelatinatum 18.5, Concha Ostreae 18.5, Os Draconis 18.5, Stigma Croci 9.25, catechu 9.25, Pyritum (forging) 9.25, Fructus Amomi 9.25, Pericarpium Citri Reticulatae Viride 9.25, Cornu Cervi Pantotrichum 5.6, Moschus 0.37;
Each above-mentioned crude drug is weight ratio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610170815XA CN100469388C (en) | 2006-12-27 | 2006-12-27 | Chinese medicine for treating femoral head necrosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610170815XA CN100469388C (en) | 2006-12-27 | 2006-12-27 | Chinese medicine for treating femoral head necrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101020023A true CN101020023A (en) | 2007-08-22 |
| CN100469388C CN100469388C (en) | 2009-03-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610170815XA Expired - Fee Related CN100469388C (en) | 2006-12-27 | 2006-12-27 | Chinese medicine for treating femoral head necrosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100469388C (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284044B (en) * | 2008-05-29 | 2011-05-04 | 陕西中医学院 | Chinese medicinal composition for treating ischemic necrosis of femoral head and its preparation method |
| CN102846943A (en) * | 2012-09-28 | 2013-01-02 | 郑州中医骨伤病医院 | Femoral head necrosis rehabilitation pill |
| CN103251767A (en) * | 2013-04-17 | 2013-08-21 | 张建华 | Traditional Chinese medicine for treating femoral head necrosis |
| CN103263480A (en) * | 2013-05-31 | 2013-08-28 | 北京振东光明药物研究院有限公司 | Pharmaceutical composition for treating femoral head necrosis and preparation method thereof |
| CN104161823A (en) * | 2014-08-19 | 2014-11-26 | 张志红 | Traditional Chinese medicine for treating aseptic necrosis of femoral head |
| CN104324358A (en) * | 2014-11-28 | 2015-02-04 | 山东省立医院 | Chinese patent medicine for treating femoral head necrosis and preparation method of Chinese patent medicine |
| CN114224991A (en) * | 2022-01-21 | 2022-03-25 | 肖涟波 | Traditional Chinese medicine composition for treating early and medium hormonal femoral head necrosis and application thereof |
-
2006
- 2006-12-27 CN CNB200610170815XA patent/CN100469388C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284044B (en) * | 2008-05-29 | 2011-05-04 | 陕西中医学院 | Chinese medicinal composition for treating ischemic necrosis of femoral head and its preparation method |
| CN102846943A (en) * | 2012-09-28 | 2013-01-02 | 郑州中医骨伤病医院 | Femoral head necrosis rehabilitation pill |
| CN102846943B (en) * | 2012-09-28 | 2013-11-20 | 郑州中医骨伤病医院 | Femoral head necrosis rehabilitation pill |
| CN103251767A (en) * | 2013-04-17 | 2013-08-21 | 张建华 | Traditional Chinese medicine for treating femoral head necrosis |
| CN103263480A (en) * | 2013-05-31 | 2013-08-28 | 北京振东光明药物研究院有限公司 | Pharmaceutical composition for treating femoral head necrosis and preparation method thereof |
| CN104161823A (en) * | 2014-08-19 | 2014-11-26 | 张志红 | Traditional Chinese medicine for treating aseptic necrosis of femoral head |
| CN104324358A (en) * | 2014-11-28 | 2015-02-04 | 山东省立医院 | Chinese patent medicine for treating femoral head necrosis and preparation method of Chinese patent medicine |
| CN114224991A (en) * | 2022-01-21 | 2022-03-25 | 肖涟波 | Traditional Chinese medicine composition for treating early and medium hormonal femoral head necrosis and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100469388C (en) | 2009-03-18 |
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Effective date of registration: 20080919 Address after: Department of orthopedics, Jilin Provincial Hospital of traditional Chinese medicine, No. 1478 Gong Nong Da Road, Changchun, Jilin, China: 130021 Applicant after: Zhao Wen Hai Co-applicant after: Huang Danqi Address before: Department of orthopedics, Jilin Provincial Hospital of traditional Chinese medicine, No. 1478 Gong Nong Da Road, Changchun, Jilin, China: 130021 Applicant before: Zhao Wen Hai Co-applicant before: Leng Xiangyang Co-applicant before: Huang Danqi |
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