CN104324358A - Chinese patent medicine for treating femoral head necrosis and preparation method of Chinese patent medicine - Google Patents
Chinese patent medicine for treating femoral head necrosis and preparation method of Chinese patent medicine Download PDFInfo
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- CN104324358A CN104324358A CN201410713897.2A CN201410713897A CN104324358A CN 104324358 A CN104324358 A CN 104324358A CN 201410713897 A CN201410713897 A CN 201410713897A CN 104324358 A CN104324358 A CN 104324358A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and relates to a Chinese patent medicine for treating femoral head necrosis and a preparation method of the Chinese patent medicine. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 5-10 parts of ligustrazine, 5-10 parts of ossotide, 6-8 parts of pseudo-ginseng, 6-8 parts of teasel root, 2-5 parts of calcined pyritum, 6-8 parts of drynaria rhizome, 3-6 parts of root of red-rooted salvia, 3-6 parts of eucommia ulmoides, 3-6 parts of radix achyranthis bidentatae, 2-5 parts of ground beetle, 3-6 parts of prepared rehmannia root, 3-6 parts of angelica sinensis, 2-5 parts of peach kernel, 2-5 parts of cartialgenous and 2-5 parts of liquorice. The preparation method comprises the following steps: weighing the raw materials according to the parts by weight; crushing into fine powder, filtering by an 80-100mesh sieve and then enclosing powder into a hollow capsule, wherein each capsule is 0.6-0.7g; bottling and sealing. The traditional Chinese medicine components disclosed by the invention can assist ligustrazine and ossotide in easing pain, reducing swelling, simulating osteoblast proliferation and promoting new bone formation when playing roles in removing blood stasis, connecting muscles and bones, stopping bleeding and promoting granulation; components of the traditional Chinese medicines and the western medicines cooperatively act; the treatment period for femoral head necrosis is short; and recovery is thorough.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, relate to a kind of Chinese patent medicine for the treatment of femur head necrosis and preparation method thereof.
Background technology
Femur head necrosis is a Pathologic process, initially occurs in capital heavy burden district, and under stress, necrotic bone trabecular bone structure damage and micro-fracture occurs and subsequently for the repair process of injured bone.Cause the reason of osteonecrosis not eliminate, repair imperfection, the process of damage-reparation continues, and causes femoral head structural change, collapse of the femoral head, distortion, arthritis, dysfunction.Femur head necrosis no doubt can cause slight illness, joint motion and walking with load dysfunction, but people are not by the impact of " bad and dead " word implication terror, femur head necrosis pathological changes, limits to after all, involves indivedual joint, can alleviate, disappear and spontaneous recovery, even if seriously, finally can also be remedied by artificial hip joint replacing, still walking ability can be recovered, but the method for operation is painful large, costly, after using a stage, can along with the increase of the degree of wear, and ineffective gradually, also will again replacing, is not desirable Therapeutic Method.
Chinese patent (CN103372162A) discloses a kind of plaster for the treatment of femur head necrosis, but while plaster has certain damage to skin, also have infiltration slow, take effect slow limitation.
Summary of the invention
The present invention adds ligustrazine and bone peptide on the basis of Chinese medicine preparation, is prepared into Chinese medicine capsule, has removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones, effect of hemostasia and promoting granulation, and the treatment fracture cycle is short, recovery is thorough; And adopt the preparation type of Chinese medicine capsule, eliminate peculiar abnormal flavour when Chinese herbs decoction is taken, be convenient for carrying and take.
For achieving the above object, the invention provides a kind of Chinese patent medicine for the treatment of femur head necrosis, formed by the preparation of raw material of following parts by weight: ligustrazine 5 ~ 10 parts, bone peptide 5 ~ 10 parts, Radix Notoginseng 6 ~ 8 parts, Radix Dipsaci 6 ~ 8 parts, Pyritum (calcined) 2 ~ 5 parts, Rhizoma Drynariae 6 ~ 8 parts, Radix Salviae Miltiorrhizae 3 ~ 6 parts, the Cortex Eucommiae 3 ~ 6 parts, Radix Achyranthis Bidentatae 3 ~ 6 parts, eupolyphoge sinensis 2 ~ 5 parts, Radix Rehmanniae Preparata 3 ~ 6 parts, Radix Angelicae Sinensis 3 ~ 6 parts, 2 ~ 5 parts, Semen Persicae, 2 ~ 5 parts, Cornu Cervi Pantotrichum, 2 ~ 5 parts, Radix Glycyrrhizae.
Be optimized for further and formed by the preparation of raw material of following parts by weight: ligustrazine 8 parts, bone peptide 8 parts, Radix Notoginseng 7 parts, Radix Dipsaci 7 parts, Pyritum (calcined) 3 parts, Rhizoma Drynariae 7 parts, Radix Salviae Miltiorrhizae 5 parts, the Cortex Eucommiae 5 parts, Radix Achyranthis Bidentatae 4 parts, eupolyphoge sinensis 3 parts, Radix Rehmanniae Preparata 5 parts, Radix Angelicae Sinensis 5 parts, 3 parts, Semen Persicae, 4 parts, Cornu Cervi Pantotrichum, 4 parts, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder crosses 80 ~ 100 mesh sieves and medicated powder is loaded Capsules, 0.6 ~ 0.7 gram every, bottling sealing.
Pharmacology analysis:
Ligustrazine: the effect of have antiplatelet aggregation, expand small artery, improve microcirculation and cerebral blood flow.For obliterative vascular disease, cerebral thrombosis, vasculitis, coronary heart diseases and angina pectoris etc.
Bone peptide: be made up of health pig or fetal bovine limb bone extract bone peptide powder.There is biologic activity widely, can bone metabolism be improved, and have good analgesia, antiinflammation, have and regulate bone metabolism, stimulated osteoblastic proliferation, promote new bone formation, and regulate Ca,P metabolism, increase bone doped calcium, prevent and treat osteoporosis effect.
Radix Notoginseng: sweet micro-hardship, temperature.Enter liver, stomach, large intestine channel.Function hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.
Radix Dipsaci: invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.Control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer swells.
Pyritum (calcined): for treating swelling and pain by traumatic injury, injured bone.Enter the loose clothes of ball more; External is ground into powder and is dressed.
Rhizoma Drynariae: bitter, temperature.Enter liver, kidney channel.The kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.
Radix Salviae Miltiorrhizae: nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
The Cortex Eucommiae: sweet in the mouth, warm in nature.Return liver, kidney, stomach warp.Effect liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.The lumbago and skelalgia or aching and limp unable that treatment insufficiency of kidney-YANG causes.Born of the same parents' tire that deficiency of liver-QI causes is not solid, the diseases such as scrotum pruritus due to damp pathogen.
Radix Achyranthis Bidentatae: sweetness and bitterness acid is flat.Life uses dissipating blood stasis blood, subduing inflammation.Control gonorrhea, hematuria, amenorrhea, lump in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury.Ripe invigorating the liver and kidney, bone and muscle strengthening.Control waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.
Eupolyphoge sinensis: salty, cold; Slightly poisonous.Return Liver Channel.Function cures mainly removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
Radix Rehmanniae Preparata: sweet in the mouth, warm in nature.Return liver, kidney channel.Enrich blood moist, benefit essence fills out marrow, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, collapse that more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, menoxenia, metrostaxis, soreness of the waist and knees, Hiccough and deaf, the head are dim-sighted, early whitening of beard and hair, quench one's thirst, constipation, dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Radix Angelicae Sinensis: sweet, pungent, warm.Return liver, the heart, spleen channel.Cure mainly all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down.
Semen Persicae: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Cornu Cervi Pantotrichum: kidney-Yang invigorating, fill blood, beneficial marrow, bone and muscle strengthening.Cure mainly diseases such as suffering from a deficiency of the kidney, dizzy, deaf, order is dark, sexual impotence, spermatorrhea, cold womb are infertile, weakness and emaciation, Mental fatigue, fear of cold, spinal column cold type of pain, muscles and bones flaccidity are soft, bleeding not during menses, carbuncle of yin nature are not held back and prolonged illness is deficient.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.For severe palpitation, the irregularly intermittent and regularly intermittent pulse of deficiency of heart-QI, pathopyretic ulcer, laryngopharynx swelling and pain.
The present invention is in conjunction with the effect of Chinese and western medical, prove through years of researches and clinical practice: Chinese medicinal components of the present invention can at performance removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones, while effect of hemostasia and promoting granulation, assist the function of the analgesia of ligustrazine and bone peptide, detumescence, stimulated osteoblastic proliferation, promotion new bone formation, Chinese medicine and western medicine component synergism, the treatment fracture cycle is short, recovery is thorough.
Outcome measure:
Recovery from illness: walking is without row of crossing mountains, and hip joint is without pain, and lower limb are without secondary cripetura, and function is recovered completely or substantially, X-ray film femoral head sequestrum district subsides, osteonecrosis and bone regeneration hardening phenomenon disappear substantially;
Take a turn for the better: symptom alleviates, hip joint movable function improves, and Lower limb shortening is at about 1cm, and X-ray film femoral head becomes large or flat, but osteonecrosis and bone regeneration hardening phenomenon are improved;
Invalid: symptom is without improvement, and X-ray film sign is without improvement;
Therapeutic outcome: treat 1285 Patients with Aseptic Necrosis of Femorals, use 2 the course for the treatment of Chinese patent medicine of the present invention, twice on the one, one time 2, decoction being taken warmly after meal 2 weeks is a course for the treatment of.Recovery from illness 1249 example, accounts for 97.2%, and take a turn for the better 30 examples, accounts for 2.3%, and invalid 6 examples, account for 0.5%.
Attached several routine case is described further:
Case 1: Wu, man, 48 years old, once ate hormone drug treatment lumbar muscle strain, also there is the experience of wound, can not normally to walk because of bilateral hip joint constant pain afterwards, and came here and go to a doctor, be diagnosed as femur head necrosis, after take Chinese patent medicine of the present invention, take a turn for the better after 1 course for the treatment of, fully recover after 2 courses for the treatment of and leave hospital.
Case 2: Feng so-and-so, female, 29 years old, carrys out double hip joint limitation of activity when institute goes to a doctor, anteflexion L90 °, R80 °, after stretch L4 °, R1 °, adduction L15 °, R5 °, abduction L30 °, R10 °, outward turning L30 °, R10 °, inward turning L20 °, R5 °.Extensive tenderness around total range of motion L189 °, R101 ° of right hip joint, left side groin mid point is lower outside, greater trochanter tenderness, and bilateral " 4 " word is tested, and right lateral thigh rolling test, greater trochanter percussion test are all positive.Atrophy that right quadriceps femoris is slight.Bilateral femoral head MR is on average shown in that bilateral femoral head becomes flat (attaching most importance to right side), the visible long T1 of lamellar in bilateral femoral head, long T2 abnormal signal stove, pressure fat resembles in high signal, double hip joint gap turn narrow, right hips intracavity is shown in a large amount of long T1, long T2 liquid signal.X-ray film shows: right lateral thigh bone profile is irregular, and right lateral thigh bone becomes flat, and bilateral femoral head bone trabecula is disorderly, and right lateral thigh bone is dispersed in cystis degeneration district.X-ray film Ficat is L III A by stages, R III B, and difficulty in walking, after restraint, pain can be stood.After take Chinese patent medicine of the present invention, take a turn for the better after 1 course for the treatment of, fully recover after 2 courses for the treatment of and leave hospital.
Detailed description of the invention
Embodiment 1:
Treat a Chinese patent medicine for femur head necrosis, formed by the preparation of raw material of following parts by weight: ligustrazine 8 parts, bone peptide 8 parts, Radix Notoginseng 7 parts, Radix Dipsaci 7 parts, Pyritum (calcined) 3 parts, Rhizoma Drynariae 7 parts, Radix Salviae Miltiorrhizae 5 parts, the Cortex Eucommiae 5 parts, Radix Achyranthis Bidentatae 4 parts, eupolyphoge sinensis 3 parts, Radix Rehmanniae Preparata 5 parts, Radix Angelicae Sinensis 5 parts, 3 parts, Semen Persicae, 4 parts, Cornu Cervi Pantotrichum, 4 parts, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder crosses 90 mesh sieves and medicated powder is loaded Capsules, 0.6 gram every, bottling sealing.
Embodiment 2:
Treat a Chinese patent medicine for femur head necrosis, formed by the preparation of raw material of following parts by weight: ligustrazine 5 parts, bone peptide 10 parts, Radix Notoginseng 6 parts, Radix Dipsaci 8 parts, Pyritum (calcined) 2 parts, Rhizoma Drynariae 8 parts, Radix Salviae Miltiorrhizae 3 parts, the Cortex Eucommiae 6 parts, Radix Achyranthis Bidentatae 3 parts, eupolyphoge sinensis 5 parts, Radix Rehmanniae Preparata 3 parts, Radix Angelicae Sinensis 6 parts, 2 parts, Semen Persicae, 5 parts, Cornu Cervi Pantotrichum, 2 parts, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder crosses 100 mesh sieves and medicated powder is loaded Capsules, 0.6 gram every, bottling sealing.
Embodiment 3:
Treat a Chinese patent medicine for femur head necrosis, formed by the preparation of raw material of following parts by weight: ligustrazine 10 parts, bone peptide 5 parts, Radix Notoginseng 8 parts, Radix Dipsaci 6 parts, Pyritum (calcined) 5 parts, Rhizoma Drynariae 6 parts, Radix Salviae Miltiorrhizae 6 parts, the Cortex Eucommiae 3 parts, Radix Achyranthis Bidentatae 6 parts, eupolyphoge sinensis 2 parts, Radix Rehmanniae Preparata 6 parts, Radix Angelicae Sinensis 3 parts, 5 parts, Semen Persicae, 2 parts, Cornu Cervi Pantotrichum, 5 parts, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder crosses 80 mesh sieves and medicated powder is loaded Capsules, 0.7 gram every, bottling sealing.
Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.
Claims (3)
1. the invention provides a kind of Chinese patent medicine for the treatment of femur head necrosis, it is characterized in that being formed by the preparation of raw material of following parts by weight: ligustrazine 5 ~ 10 parts, bone peptide 5 ~ 10 parts, Radix Notoginseng 6 ~ 8 parts, Radix Dipsaci 6 ~ 8 parts, Pyritum (calcined) 2 ~ 5 parts, Rhizoma Drynariae 6 ~ 8 parts, Radix Salviae Miltiorrhizae 3 ~ 6 parts, the Cortex Eucommiae 3 ~ 6 parts, Radix Achyranthis Bidentatae 3 ~ 6 parts, eupolyphoge sinensis 2 ~ 5 parts, Radix Rehmanniae Preparata 3 ~ 6 parts, Radix Angelicae Sinensis 3 ~ 6 parts, 2 ~ 5 parts, Semen Persicae, 2 ~ 5 parts, Cornu Cervi Pantotrichum, 2 ~ 5 parts, Radix Glycyrrhizae.
2. the Chinese patent medicine for the treatment of femur head necrosis as claimed in claim 1, is characterized in that being formed by the preparation of raw material of following parts by weight: ligustrazine 8 parts, bone peptide 8 parts, Radix Notoginseng 7 parts, Radix Dipsaci 7 parts, Pyritum (calcined) 3 parts, Rhizoma Drynariae 7 parts, Radix Salviae Miltiorrhizae 5 parts, the Cortex Eucommiae 5 parts, Radix Achyranthis Bidentatae 4 parts, eupolyphoge sinensis 3 parts, Radix Rehmanniae Preparata 5 parts, Radix Angelicae Sinensis 5 parts, 3 parts, Semen Persicae, 4 parts, Cornu Cervi Pantotrichum, 4 parts, Radix Glycyrrhizae.
3. the method for the Chinese patent medicine of preparation treatment as claimed in claim 1 femur head necrosis, it is characterized in that being made up of following steps: take raw material by above-mentioned parts by weight, be ground into after fine powder crosses 80 ~ 100 mesh sieves and medicated powder is loaded Capsules, 0.6 ~ 0.7 gram every, bottling sealing.
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| CN201410713897.2A CN104324358B (en) | 2014-11-28 | 2014-11-28 | A kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof |
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| CN201410713897.2A CN104324358B (en) | 2014-11-28 | 2014-11-28 | A kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof |
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| CN104324358A true CN104324358A (en) | 2015-02-04 |
| CN104324358B CN104324358B (en) | 2016-05-25 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946955A (en) * | 2019-12-19 | 2020-04-03 | 聊城市华硕医院有限公司 | Bone-strengthening soup formula |
| CN114042146A (en) * | 2021-11-11 | 2022-02-15 | 安徽国肽生物科技有限公司 | Bovine bone peptide composition and application thereof in preparing medicines for regulating intestinal flora and preventing and treating osteoporosis |
Citations (2)
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| CN101020023A (en) * | 2006-12-27 | 2007-08-22 | 赵文海 | Chinese medicine for treating femoral head necrosis |
| CN103536712A (en) * | 2013-10-11 | 2014-01-29 | 尹爱斌 | Chinese medicine preparation for treating femoral head necrosis |
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2014
- 2014-11-28 CN CN201410713897.2A patent/CN104324358B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101020023A (en) * | 2006-12-27 | 2007-08-22 | 赵文海 | Chinese medicine for treating femoral head necrosis |
| CN103536712A (en) * | 2013-10-11 | 2014-01-29 | 尹爱斌 | Chinese medicine preparation for treating femoral head necrosis |
Non-Patent Citations (2)
| Title |
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| 郑德先等: "骨肽与川芎嗪组方在成人股骨头缺血坏死介入治疗中的疗效分析", 《实用诊断与治疗杂志》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946955A (en) * | 2019-12-19 | 2020-04-03 | 聊城市华硕医院有限公司 | Bone-strengthening soup formula |
| CN114042146A (en) * | 2021-11-11 | 2022-02-15 | 安徽国肽生物科技有限公司 | Bovine bone peptide composition and application thereof in preparing medicines for regulating intestinal flora and preventing and treating osteoporosis |
| CN114042146B (en) * | 2021-11-11 | 2024-04-30 | 安徽国肽生物科技有限公司 | Bovine bone peptide composition and application thereof in preparation of medicines for regulating intestinal flora and preventing and treating osteoporosis |
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