CN103536712A

CN103536712A - Chinese medicine preparation for treating femoral head necrosis

Info

Publication number: CN103536712A
Application number: CN201310491609.9A
Authority: CN
Inventors: 尹爱斌; 宫会霞; 崔兴凤
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-10-11
Filing date: 2013-10-11
Publication date: 2014-01-29

Abstract

The invention discloses a Chinese medicine preparation for treating femoral head necrosis. According to ancient Chinese medicine books, femoral head necrosis belongs to diseases of bone erosion, heumatism and the like, and the diseases can be resulted from congenitally deficiency, acquired malnutrition, work and leisure, trauma, maltreatment and therapeutic errors. The Chinese medicine preparation is prepared by boiling Chinese medicines, namely, pyrola, holly leaves, autumn zephyrlily herb, root of crinite uraria, banian leaves, stylophorum lasiocarpum, root of schoch craspedolobium, cow marrow, deer sinew, tiger bone glue, mutton marrow and glaucousback with the functions of tonifying the liver and kidney, strengthening tendons and bones, promoting blood circulation to remove blood stasis and activating main and collateral channels, in water to be prepared into decoction. Clinical tests show that the total effective rate is 89.4%, which is remarkably superior to that of a control group.

Description

A kind of Chinese medicine preparation for the treatment of femur head necrosis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of femur head necrosis.

Background technology

Femur head necrosis refers to that blood supply of the femoral head is obstructed and the bone active composition that causes is dead, and femur head necrosis is more common clinically, wherein take fracture of femoral neck as causing the common cause of femur head necrosis, and necrosis mostly occurs at 1-5.For early, the femur head necrosis in mid-term, doctor trained in Western medicine is often taked expectant treatment clinically, but effect is desirable not to the utmost, the clinical practice of several years proves, Chinese traditional treatment femoral head osteonecrosis cost is low, treatment is simple, clinical effectiveness is remarkable.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of femur head necrosis.Femur head necrosis belongs to the sick categories such as " osteomyelitis " " rheumatism involving the bone " in ancient Chinese doctor nationality.Congenital defect, the day after tomorrow lose and support, work and rest, wound, mistake are controlled wrong treatment and all can be caused the generation of primary disease.The congenital foundation is kidney, the kidney generating marrow and dominating bone congenital defect, and deficiency of both the liver and kidney, femoral head epiphyseal dysplasia or acetabular dysplasia, marrow joint congenital dislocation, all can cause femur head necrosis.Wound is local in hip joint by External Force Acting, and the lighter's skin and flesh is impaired, and bone break the muscle wound appears in severe patient, makes meridians, the impaired qi depression to blood stasis of muscle arteries and veins, and QI and blood can not be stored up muscles and bones and be occurred thigh pivot numbness, and bone withers.It is method that liver and kidney tonifying, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, soothing the channels and quicking the network vessels are take in treatment.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment femur head necrosis is made by the Chinese medicine of following weight portion: Herba Pyrolae 25-50 part, Folium Ilicis Cornutae 15-25 part, Herba Zephyranthis Candidae 15-35 part, Radix Urariae crinitae 15-25 part, Folium fici microcarpae 15-25 part, Herba Stylophori Lasiocapi 5-15 part, Radix craspedolobii schochii 10-15 part, Medulla Bovis seu Bubali 50-80 part, Ligamentum cervi 50-70 part, Colla Os Tigris 5-10 part, Medulla caprae seu ovis 30-50 part, Cortex tripterygii hypoglauci radicis 15-35 part.

Preferably, 35 parts of Herba Pyrolaes, 20 parts of Folium Ilicis Cornutaes, 25 parts of Herba Zephyranthis Candidaes, 20 parts of Radix Urariae crinitaes, 20 parts of Folium fici microcarpaes, 10 parts of Herba Stylophori Lasiocapis, 12 parts, Radix craspedolobii schochii, 65 parts of Medulla Bovis seu Bubali, 60 parts of Ligamentum cervis, 8 parts of Colla Os Tigriss, 40 parts of Medulla caprae seu ovis, 25 parts of Cortex tripterygii hypoglauci radiciss.

Preparation method: Chinese medicine decocting is made to decoction.

In side: Herba Pyrolae tonify deficiency kidney tonifying, expelling wind and activating blood circulation; Folium Ilicis Cornutae invigorating the liver and kidney, qi and blood invigorating; Herba Zephyranthis Candidae suppressing the hyperactive liver to relieve the wind syndrome; Radix Urariae crinitae is regulated the flow of vital energy, reduces phlegm, and kidney tonifying; Folium fici microcarpae promoting blood circulation to remove blood stasis, analgesic reason is wet; The detumescence of Herba Stylophori Lasiocapi's removing blood stasis with potent drugs, hemostasis and pain-relieving; Radix craspedolobii schochii promoting blood circulation and hemostasis, expelling wind and removing dampness; Medulla Bovis seu Bubali lung moistening, the kidney invigorating, fills out marrow; Ligamentum cervi, Colla Os Tigris benefiting vital QI and blood, strong muscles and bones; Medulla caprae seu ovis tonifying YIN is mended marrow, lung moistening pool flesh; Cortex tripterygii hypoglauci radicis reunion of fractured tendons and bones, eliminating blood stasis and smoothing collaterals.

Clinical data

1, to observe case be the patient of in January, 2010～2012 year Jian in January the court outpatient clinic to physical data, and totally 170 examples are all diagnosed as the commitment of femur head necrosis.Be divided at random two groups, treatment group man 45 examples, female's 40 examples, 35～62 years old age, average 49.6 years old, the course of disease 1～12 year.Matched group man 47 examples, female's 38 examples, the age is 33～61 years old, average 50.3 years old, the course of disease 1～13 year.Two groups at aspects such as sex, age, the course of disease, the state of an illness without significant difference (P > 0.05), there is comparability.

2, diagnostic criteria (1) pain.The position of pain is around hip joint, femoribus internus, front side or knee.(2) ankylosis and limitation of activity.Along with the development patient of the state of an illness slowly there will be hip joint joint stuffiness, the difficulty of squatting down, can not stand for a long time, the duck that walks step.(3) walk lamely.Generally show as cripetura and walk lamely, due to hip pain and collapse of the femoral head, or occur due to hip joint subluxation late period.(4) sign performance.Local dark tenderness, adductor stop tenderness, 4 word tests are positive, and gal coffee s levies the positive, and A11i s levies the positive test positive.Abduction, outward turning or inward turning limitation of activity, suffering limb can shorten, amyotrophy.(5) x-ray performance.Bone texture is tiny or interrupt, femoral head cyst, sclerosis, flat or subside.

3, Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention.Take Herba Pyrolae 35g, Folium Ilicis Cornutae 20g, Herba Zephyranthis Candidae 25g, Radix Urariae crinitae 20g, Folium fici microcarpae 20g, Herba Stylophori Lasiocapi 10g, Radix craspedolobii schochii 12g, Medulla Bovis seu Bubali 65g, Ligamentum cervi 60g, Colla Os Tigris 8g, Medulla caprae seu ovis 40g, Cortex tripterygii hypoglauci radicis 25g, decocting becomes decoction, every day potion, divide and sooner or later take for 2 times, serveing on 7 days is a course for the treatment of; Matched group gives oral lovastatin sheet 10mg, every day 2 times; PWN-A type microwave therapy apparatus with frequency 915MHz, penetration depth 4-6cm, at Ipsilateral groin place, irradiates by the circular radiator of diameter 16cm, apart from 10-15cm, power 20-60w, every day 10-20 minute, every day 1 time.All treat continuously 5 courses for the treatment of for two groups.

4, criterion of therapeutical effect (1) recovery from illness: pain obviously disappears, X-ray or CT, MR show that recovering appears in the bone structure femoral head that particularly subsides, new bone growth, bone trabecular carrying and tension system form are bordering on normally, its intensity and density improvement.(2) effective: pain is obviously alleviated or disappeared, various functions is clearly better or substantially recovers, and X-ray shows that necrotic area destruction has stopped ，Nang Bian district and obviously dwindled, and occurs bone trabecula growth and reconstruction; (3) effective: pain relief, hip joint range of activity and gait be front improvement, and X-ray necrotic area is stable, and sequestrum has absorption, and bone trabecular structure has the trend of reconstruction again; (4) invalid: pain, hip joint various functions are without change, and X-ray worsens before showing treatment.

5, curative effect comparison after 5 courses for the treatment of of two groups of therapeutic outcomes treatment, treatment group 85 examples, wherein cure 52 examples (61.2%), effective 11 examples (12.9%), effective 13 examples (15.3%), no effect 9 (10.6%), total effective rate 89.4%; Matched group 85 examples, wherein cure 30 examples (35.3%), effective 17 examples (20%), effective 15 examples (17.6%), invalid 23 examples (27.1%), total effective rate 72.9%.Two groups of comparisons, treatment group cure rate, total effective rate are obviously better than matched group, have comparability (P < 0.05).

The specific embodiment

Embodiment mono-: take Herba Pyrolae 35g, Folium Ilicis Cornutae 20g, Herba Zephyranthis Candidae 25g, Radix Urariae crinitae 20g, Folium fici microcarpae 20g, Herba Stylophori Lasiocapi 10g, Radix craspedolobii schochii 12g, Medulla Bovis seu Bubali 65g, Ligamentum cervi 60g, Colla Os Tigris 8g, Medulla caprae seu ovis 40g, Cortex tripterygii hypoglauci radicis 25g, above-mentioned Chinese medicine decocting is made to decoction.

Embodiment bis-: take Herba Pyrolae 25g, Folium Ilicis Cornutae 25g, liver phoenix grass 15g, Radix Urariae crinitae 25g, Folium fici microcarpae 15g, Herba Stylophori Lasiocapi 15g, Radix craspedolobii schochii 10g, Medulla Bovis seu Bubali 80g, Ligamentum cervi 50g, Colla Os Tigris 10g, Medulla caprae seu ovis 30g, Cortex tripterygii hypoglauci radicis 35g, above-mentioned Chinese medicine decocting is made to decoction.

Embodiment tri-: take Herba Pyrolae 50g, Folium Ilicis Cornutae 15g, Herba Zephyranthis Candidae 35g, Radix Urariae crinitae 15g, Folium fici microcarpae 25g, Herba Stylophori Lasiocapi 5g, Radix craspedolobii schochii 15g, Medulla Bovis seu Bubali 50g, Ligamentum cervi 70g, Colla Os Tigris 5g, Medulla caprae seu ovis 50g, Cortex tripterygii hypoglauci radicis 15g, above-mentioned Chinese medicine decocting is made to decoction.

Claims

1. treat a Chinese medicine preparation for femur head necrosis, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Herba Pyrolae 25-50 part, Folium Ilicis Cornutae 15-25 part, Herba Zephyranthis Candidae 15-35 part, Radix Urariae crinitae 15-25 part, Folium fici microcarpae 15-25 part, Herba Stylophori Lasiocapi 5-15 part, Radix craspedolobii schochii 10-15 part, Medulla Bovis seu Bubali 50-80 part, Ligamentum cervi 50-70 part, Colla Os Tigris 5-10 part, Medulla caprae seu ovis 30-50 part, Cortex tripterygii hypoglauci radicis 15-35 part.

2. a kind of Chinese medicine preparation for the treatment of femur head necrosis according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 35 parts of Herba Pyrolaes, 20 parts of Folium Ilicis Cornutaes, 25 parts of Herba Zephyranthis Candidaes, 20 parts of Radix Urariae crinitaes, 20 parts of Folium fici microcarpaes, 10 parts of Herba Stylophori Lasiocapis, 12 parts, Radix craspedolobii schochii, 65 parts of Medulla Bovis seu Bubali, 60 parts of Ligamentum cervis, 8 parts of Colla Os Tigriss, 40 parts of Medulla caprae seu ovis, 25 parts of Cortex tripterygii hypoglauci radiciss.