CN104324358B - A kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof - Google Patents
A kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof Download PDFInfo
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- CN104324358B CN104324358B CN201410713897.2A CN201410713897A CN104324358B CN 104324358 B CN104324358 B CN 104324358B CN 201410713897 A CN201410713897 A CN 201410713897A CN 104324358 B CN104324358 B CN 104324358B
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Abstract
The invention belongs to traditional Chinese medicine technical field, relate to a kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof. Raw material by following parts by weight is formulated: 5～10 parts of ligustrazines, 5～10 parts of bone peptides, 6～8 parts of pseudo-ginseng, 6～8 parts of teasel roots, 2～5 parts of pyritum igniteds, 6～8 parts of the rhizomes of davallia, 3～6 parts of the reds sage root, 3～6 parts of the barks of eucommia, 3～6 parts of the roots of bidentate achyranthes, 2～5 parts of eupolyphoge sinensis, 3～6 parts of prepared rhizomes of rehmannia, 3～6 parts of Radix Angelicae Sinensis, 2～5 parts, peach kernel, 2～5 parts, pilose antler, 2～5 parts, Radix Glycyrrhizae. Preparation method takes raw material by above-mentioned parts by weight, and be ground into after fine powder is crossed 80～100 mesh sieves and pack medicinal powder into Capsules, 0.6～0.7 gram every, bottling sealing. Traditional Chinese medicinal components of the present invention can be at the broken hemostasis of performance, continuous muscles and bones, when effect of hemostasia and promoting granulation, the function of the new bone formation of analgesia, detumescence, stimulated osteoblastic proliferation, promotion of auxiliary ligustrazine and bone peptide, Chinese and Western medicine component synergy, the treatment caput femoris necrosis cycle is short, recovery is thorough.
Description
Technical field
The invention belongs to traditional Chinese medicine technical field, relate to a kind of Chinese patent drug and preparation thereof for the treatment of caput femoris necrosisMethod.
Background technology
Caput femoris necrosis is a Pathologic process, initially occurs in capital heavy burden district, under effect of stressDamage occurs necrotic bone trabecular bone structure is micro-fracture and subsequently for the repair process of damaged bone tissue. MakeBecome the reason of osteonecrosis not eliminate, repair imperfection, the process of damage-reparation continues, and causes femoral head structureChange, collapse of femoral head, distortion, arthritis, dysfunction. Caput femoris necrosis no doubt can cause slight illness,Joint motion and heavy burden walking function obstacle, but people are not subject to the impact of " bad and dead " word implication terror,Caput femoris necrosis pathology, limitation, involves indivedual joints after all, can alleviate, disappear and self-healing, even if serious,Finally can also remedy by artificial hip joint replacing, still can recover walking ability, but the method for operation is painful large,Expense is high, uses after the stage, understands the increase along with the degree of wear, and ineffective gradually, also will be againDisplacement is not desirable methods for the treatment of.
Chinese patent (CN103372162A) discloses a kind of plaster for the treatment of caput femoris necrosis, but plaster is to skinWhen skin has certain damage, also have infiltration slow, slow limitation takes effect.
Summary of the invention
The present invention adds ligustrazine and bone peptide on the basis of Chinese medicine preparation, is prepared into Chinese medicine capsule, has brokenHemostasis, continuous muscles and bones, effect of hemostasia and promoting granulation, the treatment fracture cycle is short, recovery is thorough; And employing Chinese patent drugThe preparation type of capsule, peculiar peculiar smell when having eliminated Chinese herbs decoction and taking, is convenient for carrying and takes.
For achieving the above object, the invention provides a kind of Chinese patent drug for the treatment of caput femoris necrosis, by following weight portionThe raw material of number is formulated: 5～10 parts of ligustrazines, 5～10 parts of bone peptides, 6～8 parts of pseudo-ginseng, teasel root 6～8Part, 2～5 parts of pyritum igniteds, 6～8 parts of the rhizomes of davallia, 3～6 parts of the reds sage root, 3～6 parts of the barks of eucommia, the root of bidentate achyranthes 3～6 parts, 2～5 parts of eupolyphoge sinensis, 3～6 parts of prepared rhizomes of rehmannia, 3～6 parts of Radix Angelicae Sinensis, 2～5 parts, peach kernel, pilose antler 2～52～5 parts, part, Radix Glycyrrhizae.
Further be optimized for by the raw material of following parts by weight formulated: 8 parts of 8 parts of ligustrazines, bone peptide, three77 parts, 7 parts of teasel roots, 3 parts of pyritum igniteds, 7 parts of the rhizomes of davallia, 5 parts of the reds sage root, 5 parts of the barks of eucommia, the root of bidentate achyranthes 4Part, 3 parts of eupolyphoge sinensis, 5 parts of prepared rhizomes of rehmannia, 5 parts of Radix Angelicae Sinensis, 3 parts, peach kernel, 4 parts, pilose antler, 4 parts, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into fine powder and crosses after 80～100 mesh sieves medicinal powderPack Capsules into, 0.6～0.7 gram every, bottling sealing.
Pharmacology analysis:
Ligustrazine: have platelet aggregation-against, expand parteriole, improve the effect of microcirculation and brain blood flow. Be used forObliterative vascular disease, cerebral thrombosis, vasculitis, coronary heart diseases and angina pectoris etc.
Bone peptide: made by health pig or fetal bovine limb bone extract bone peptide powder. There is BA widely,Can improve bone metabolism, and have good analgesia, antiinflammation, there is the metabolism of the bone of adjusting, stimulating osteoblastPropagation, promotes new bone to form, and regulates calcium, phosphorus metabolism, increases bone calcium deposition, prevents and treats osteoporosis effect.
Pseudo-ginseng: sweet micro-hardship, temperature. Enter liver, stomach, large intestine channel. Function hemostasis, the loose stasis of blood, detumescence, analgesic therapy. ControlSpit blood, hemoptysis, bleeding from five sense organs or subcutaneous tissue, has blood in stool, bloody flux, uterine bleeding, abdominal mass, postpartum anemic fainting, lochia not under, fall and flutter hemostasis,Traumatism and bleeding, the carbuncle pain that swells.
Teasel root: filling liver kidney, continuous muscles and bones, adjusts blood vessels. Control aching pain in waist and back, the foot and knee being feeble, threatened abortion, uterine bleeding, bandUnder, seminal emission, traumatic injury, metal-inflicted wound, anal fistula, ulcer sore is swollen.
Pyritum ignited: for treating swelling and pain by traumatic injury, injured bone. Enter the loose clothes of ball more; External application is ground into powder and is dressed.
The rhizome of davallia: hardship, temperature. Enter liver, kidney channel. The strong bone of kidney tonifying, continues and hinders pain relieving. For lumbago due to the kidney deficiency, tinnitusDeafness, tooth mobility, falling winks frustrates, injured bone; Control alopecia areata outward, leucoderma.
The red sage root: nature and flavor hardship, is slightly cold. The thoughts of returning home, Liver Channel. There is stasis-dispelling and pain-killing, activating blood to promote menstruation, the merit of the relieving restlessness that clears away heart-fireEffect. For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, the heartTired egersis; Hepatosplenomegaly, angina pectoris.
The bark of eucommia: taste is sweet, warm in nature. Return liver, kidney, stomach warp. Effect tonifies the liver and kidney, strengthens muscles and bones, coordinating Chong and Conception Vessels,Gu through antiabortive. The pain in waist and lower extremities that treatment kidney-yang deficiency causes or aching and limp unable. Born of the same parents' tire that irritability void causes is not solid, scrotumThe wet disease such as itch.
The root of bidentate achyranthes: sweetness and bitterness acid, flat. Raw with loose hemostasis, subduing inflammation. Control gonorrhoea, hematuria, through closing, abdominal mass, difficultyProduce, placenta retension, postpartum blood stasis stomachache, larynx numbness, carbuncle is swollen, traumatic injury. Ripe in filling liver kidney, strengthening the bones and muscles.Control waist kneecap pain, spasm of limbs, impotence numbness.
Eupolyphoge sinensis: salty, cold; Slightly poisonous. Return Liver Channel. Function cures mainly brokenly hemostasis, continuous muscles and bones. For injured bone,Hemostasis is through closing, abdominal mass lump in the abdomen.
Prepared rhizome of rehmannia: taste is sweet, warm in nature. Return liver, kidney channel. Enrich blood moist, beneficial essence is filled out marrow, sallow for the deficiency of blood,Dizzy palpitaition, irregular menstruation, collapse more than, liver-kidney Yin deficiency, hectic fever night sweat, seminal emission impotence, infertility, the moon, poliosis dim-sighted through uncomfortable, metrostaxis, soreness and weakness of waist and knees, Hiccough and deaf, the head, quench one's thirst, constipation,The syndrome characterized by dyspnea of suffering from a deficiency of the kidney.
Radix Angelicae Sinensis: sweet, pungent, warm. Return liver, the heart, the spleen channel. Cure mainly all cards of the deficiency of blood, irregular menstruation, through closing, bitterlyWarp, abdominal mass knot is poly-, uterine bleeding, asthenia cold abdominalgia, impotence numbness, numbness, intestines are dry just difficult, heavy after dysentery characterized by blood in the stool, ulcerSore, injury from falling down.
Peach kernel: the broken blood stasis of blood, moisturize laxation. Control through closing, abdominal mass, pyreticosis is held blood, wandering arthritis, malaria, falls and beatsDamage, blood stasis and swelling pain, the dry constipation of blood.
Pilose antler: kidney-Yang invigorating, fill blood, beneficial marrow, strengthening the bones and muscles. Cure mainly suffer from a deficiency of the kidney, dizzy, deaf, order is dark,Impotence, involuntary emission, palace cold infertile, thin thin, god is tired, chilly, spinal column crymodynia, muscles and bones impotence are soft, under uterine bleeding band,The diseases such as cloudy subcutaneous ulcer is not held back and prolonged illness is deficient.
Radix Glycyrrhizae: sweet, flat, the thoughts of returning home, lung, spleen, stomach warp. The bowl spares of benefit gas, clearing heat and detoxicating, expelling phlegm and arresting coughing, slowAnxious pain relieving, the mediation property of medicine. For severe palpilation, the intermittent pulse of deficiency of heart-QI, pathopyretic ulcer, abscess of throat.
The present invention, in conjunction with the effect of Chinese and western medical, proves through years of researches and clinical practice: Chinese drug-treated group of the present inventionPoint can be at the broken hemostasis of performance, continuous muscles and bones, when effect of hemostasia and promoting granulation, the town of auxiliary ligustrazine and bone peptideBitterly, the function of detumescence, stimulated osteoblastic proliferation, the new bone formation of promotion, Chinese and Western medicine component synergy, controlsThe treatment fracture cycle is short, recovery is thorough.
Curative effect judgement:
Recovery from illness: walking is without the row of crossing mountains, and hip joint is without pain, and lower limb are without secondary cripetura, and function is recovered completely or substantially,X-ray film femoral head sequestrum district subsides, osteonecrosis and bone regeneration hardening phenomenon disappear substantially;
Take a turn for the better: symptom alleviates, hip joint movable function improves, and lower limb cripetura is at 1cm left and right, X-ray film thighIt is large or flat that bone becomes, but osteonecrosis and bone regeneration hardening phenomenon are improved;
Invalid: symptom is without improvement, and X-ray film sign is without improvement;
Treatment results: treat 1285 Patients with Aseptic Necrosis of Femorals, use 2 the course for the treatment of Chinese patent drug of the present invention,Twice, one time on the one 2, warmly take after meal, within 2 weeks, be a course for the treatment of. 1249 examples of fully recovering, account for 97.2%, goodTurn 30 examples, account for 2.3%, invalid 6 examples, account for 0.5%.
Attached several routine case is described further:
Case 1: Wu, man, 48 years old, once ate hormone drug treatment lumbar muscle strain, also there is the experience of wound,Because of bilateral hip joint constant pain, can not normally walk afterwards, come here medical, be diagnosed as caput femoris necrosis, afterTake Chinese patent drug of the present invention, after 1 course for the treatment of, take a turn for the better, after 2 courses for the treatment of, fully recover and leave hospital.
Case 2: Feng so-and-so, female, 29 years old, carry out institute's double hip joint limitation of activity when medical, anteflexion L90 °,R80 °, after stretch L4 °, R1 °, interior receipts L15 °, R5 °, abduction L30 °, R10 °, outward turning L30°, R10 °, inward turning L20 °, R5 °. Total range of motion L189 °, around R101 ° of right hip jointExtensively tenderness, left side groin mid point is lower outside, greater trochanter tenderness, the test of bilateral " 4 " word, right lateral thigh rollsDynamic test, greater trochanter percussion test are all positive. Atrophy that right quadriceps muscle of thigh is slight. Bilateral femoral head MR is on average shown inBilateral femoral head becomes flat (attaching most importance to right side), the visible long T1 of sheet in bilateral femoral head, long T2 abnormal signalKitchen range, presses fat to resemble and is high signal, and double hip joint gap turn narrow, is shown in a large amount of long T1, long T2 in right hips chamberLiquid signal. X-ray film shows: right lateral thigh bone profile is irregular, and it is flat that right lateral thigh bone becomes, bilateral femoral head boneGirder disorder, right lateral thigh bone is dispersed in cystis degeneration district. X-ray film Ficat is L III A by stages, R III B, walkingDifficulty, after restraint, pain can be stood. After take Chinese patent drug of the present invention, after 1 course for the treatment of, take a turn for the better, 2 treatmentsAfter journey, recovery from illness is left hospital.
Detailed description of the invention
Embodiment 1:
Treat a Chinese patent drug for caput femoris necrosis, formulated by the raw material of following parts by weight: ligustrazine 8Part, 8 parts of bone peptides, 7 parts of pseudo-ginseng, 7 parts of teasel roots, 3 parts of pyritum igniteds, 7 parts of the rhizomes of davallia, 5 parts of the reds sage root,5 parts of the barks of eucommia, 4 parts of the roots of bidentate achyranthes, 3 parts of eupolyphoge sinensis, 5 parts of prepared rhizomes of rehmannia, 5 parts of Radix Angelicae Sinensis, 3 parts, peach kernel, pilose antler 44 parts, part, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder is crossed 90 mesh sieves medicinal powder is packed intoCapsules, 0.6 gram every, bottling sealing.
Embodiment 2:
Treat a Chinese patent drug for caput femoris necrosis, formulated by the raw material of following parts by weight: ligustrazine 5Part, 10 parts of bone peptides, 6 parts of pseudo-ginseng, 8 parts of teasel roots, 2 parts of pyritum igniteds, 8 parts of the rhizomes of davallia, 3 parts of the reds sage root,6 parts of the barks of eucommia, 3 parts of the roots of bidentate achyranthes, 5 parts of eupolyphoge sinensis, 3 parts of prepared rhizomes of rehmannia, 6 parts of Radix Angelicae Sinensis, 2 parts, peach kernel, pilose antler 52 parts, part, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder is crossed 100 mesh sieves medicinal powder is packed intoCapsules, 0.6 gram every, bottling sealing.
Embodiment 3:
Treat a Chinese patent drug for caput femoris necrosis, formulated by the raw material of following parts by weight: ligustrazine10 parts, 5 parts of bone peptides, 8 parts of pseudo-ginseng, 6 parts of teasel roots, 5 parts of pyritum igniteds, 6 parts of the rhizomes of davallia, the red sage root 6Part, 3 parts of the barks of eucommia, 6 parts of the roots of bidentate achyranthes, 2 parts of eupolyphoge sinensis, 6 parts of prepared rhizomes of rehmannia, 3 parts of Radix Angelicae Sinensis, 5 parts, peach kernel, pilose antler5 parts of 2 parts, Radix Glycyrrhizae.
Preparation method takes raw material by above-mentioned parts by weight, is ground into after fine powder is crossed 80 mesh sieves medicinal powder is packed intoCapsules, 0.7 gram every, bottling sealing.
Below the present invention is described in detail, the above, be only the present invention's preferred embodiment,When not limiting the scope of the present invention, allly do impartial change and modify according to the application's scope, all should still belong toIn covering scope of the present invention.
Claims (1)
1. a Chinese patent drug for the treatment of caput femoris necrosis, is characterized in that: the raw material by following parts by weight is formulated,8 parts of ligustrazines, 8 parts of bone peptides, 7 parts of pseudo-ginseng, 7 parts of teasel roots, 3 parts of pyritum igniteds, 7 parts of the rhizomes of davallia, the red sage root 5Part, 5 parts of the barks of eucommia, 4 parts of the roots of bidentate achyranthes, 3 parts of eupolyphoge sinensis, 5 parts of prepared rhizomes of rehmannia, 5 parts of Radix Angelicae Sinensis, 3 parts, peach kernel, 4 parts, pilose antler,4 parts, Radix Glycyrrhizae; Preparation method is for to take raw material by above-mentioned parts by weight, is ground into fine powder and crosses after 80～100 mesh sieves medicinePowder packs Capsules into, and 0.6～0.7 gram every, bottling sealing; Drug oral uses.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410713897.2A CN104324358B (en) | 2014-11-28 | 2014-11-28 | A kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof |
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| CN201410713897.2A CN104324358B (en) | 2014-11-28 | 2014-11-28 | A kind of Chinese patent drug for the treatment of caput femoris necrosis and preparation method thereof |
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| CN104324358A CN104324358A (en) | 2015-02-04 |
| CN104324358B true CN104324358B (en) | 2016-05-25 |
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| CN110946955A (en) * | 2019-12-19 | 2020-04-03 | 聊城市华硕医院有限公司 | Bone-strengthening soup formula |
| CN114042146B (en) * | 2021-11-11 | 2024-04-30 | 安徽国肽生物科技有限公司 | Bovine bone peptide composition and application thereof in preparation of medicines for regulating intestinal flora and preventing and treating osteoporosis |
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| CN100469388C (en) * | 2006-12-27 | 2009-03-18 | 赵文海 | Chinese medicine for treating femoral head necrosis |
| CN103536712A (en) * | 2013-10-11 | 2014-01-29 | 尹爱斌 | Chinese medicine preparation for treating femoral head necrosis |
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