CN110075184A

CN110075184A - It is a kind of to treat leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain

Info

Publication number: CN110075184A
Application number: CN201910284928.XA
Authority: CN
Inventors: 田杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-04-10
Filing date: 2019-04-10
Publication date: 2019-08-02

Abstract

Leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain are treated the invention discloses a kind of, it is related to technical field of traditional Chinese medicine preparation, is made of the drug of following weight: Radix Rehmanniae pornographic movie 50g, radix scrophulariae 50g, Hu Can 50g, cortex moutan 50g, dittany bark 50g, Rhizoma Chuanxiong 50g, radix saposhnikoviae 50g, tribulus terrestris 50g, prepared fleece flower root piece 50g, psoralea corylifolia 50g, mustine hydrochlcride 10g；The present invention obtains above-mentioned Chinese medicine preparation according to the compatibility relationship of monarch, and Western medicine mustine hydrochlcride is cooperateed with to obtain pharmaceutical composition, the pharmaceutical composition has adhered to the composite treatment of the combination of Chinese tradiational and Western medicine, it can be used for the treatment of leucoderma, psoriasis, chronic eczema, sweat stain simultaneously, and it is significant in efficacy, recurrence rate is low, without side-effects.

Description

It is a kind of to treat leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain

Technical field:

The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of to treat leucoderma, psoriasis, chronic eczema, sweat The pharmaceutical composition of spot.

Background technique:

Leucoderma is a kind of posteriority depigmentation dermatoses, is due to propylhomoserin in the melanocyte of skin and hair follicle The hypofunction of system is lost and causes the skin disease characterized by limitation or general hair property depigmentation.

Psoriasis, also known as psoriasis are a kind of chronic inflammatory skins, and the course of disease is longer, there is tendency easy to recur, some diseases Example almost cannot be cured all one's life.The disease is fallen ill based on person between twenty and fifty, is affected to the health and mental status of patient.Clinical table Now with erythema, based on the scales of skin that peel off, whole body can fall ill, and with scalp, it is relatively conventional that four limbs stretch side, mostly aggravate in winter.

Chronic eczema is a kind of scytitis reaction due to caused by complicated internal and external factor excitation.Chronic eczema one As limit to and have infiltration and plumpness, acute pruritus, be easy recurrence.Pathogenic factor is complicated, and internal and external factor interaction, is often multi-party Face.Patient is often allergic constitution, and this allergic constitution is related with inherent cause, therefore is fallen ill in specific crowd.

Sweat stain, also known as pityriasis versicolor, tinea versicolor are to infect a kind of superficial fungi caused by horny layer of epidermis as chlosma Disease.This disease has slight inflammation, usual no conscious sympton in chronic.Characteristic of damage is the hypopigmentation for being dispersed in or merging or color Plain calmness spot, above has scurfy furfur, is apt to occur in chest, back, upper arm, face is also involved in oxter sometimes.

Applicating history using traditional Chinese medicine composition for treating leucoderma, psoriasis, chronic eczema, sweat stain is long, and in order to contract Short onset time and reduction recurrence rate, those skilled in the art attempt to prepare treatment using the method for Chinese medicine collaboration chemical reagent Leucoderma, psoriasis, chronic eczema, sweat stain drug, but at present this field also be not disclosed one kind can simultaneously to leucoderma, ox Psoriasis, chronic eczema, four kinds of skin diseases of sweat stain drug all with good therapeutic effect.For this problem, present invention exploitation A kind of out to treat leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain, significant in efficacy and recurrence rate is low, no secondary work With.

Summary of the invention:

Technical problem to be solved by the present invention lies in providing, one kind is significant in efficacy, recurrence rate is low, operation without side-effects Treat leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain.

The following technical solution is employed for the technical problems to be solved by the invention to realize:

It is a kind of to treat leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain, it is made of the drug of following weight:

Radix Rehmanniae pornographic movie 50g, radix scrophulariae 50g, kuh-seng 50g, cortex moutan 50g, dittany bark 50g, Rhizoma Chuanxiong 50g, radix saposhnikoviae 50g, white puncture Chenopodiaceae 50g, prepared fleece flower root piece 50g, psoralea corylifolia 50g, mustine hydrochlcride 10g.

Aforementioned pharmaceutical compositions the preparation method comprises the following steps: by Radix Rehmanniae pornographic movie, radix scrophulariae, kuh-seng, cortex moutan, dittany bark, Rhizoma Chuanxiong, anti- Wind, tribulus terrestris, prepared fleece flower root piece, psoralea corylifolia are impregnated with 75% alcohol, solution are filtered out after immersion, and be added into solution Mustine hydrochlcride is uniformly mixed.

The pharmacological action of pharmaceutical composition of the present invention:

Radix rehmanniae recen: the root tuber of glutinous rehmannia, it is sweet in flavor, it is cold in nature, enter ying blood for warm heat disease heat, the diseases such as the hot dry of body, tongue are deep red or red Shape has the effect of clearing heat and promoting fluid enriching yin, blood-nourishing, as monarch drug in a prescription.

Radix scrophulariae: the root of scrophulariaceae radix scrophulariae and scrophularia buergeriana, sweet in flavor, bitter, salty, cold nature have clearing heat and cooling blood, enriching yin drop The effect of fire, detoxicating and resolving a mass, as ministerial drug.

Kuh-seng: the dry root of leguminous plant kuh-seng, bitter is cold in nature, has the effect of heat-clearing and damp-drying drug, desinsection, diuresis, as minister Medicine.

Cortex moutan: ranunculaceae peony dry root skin, bitter, pungent, cold nature have clearing heat and cooling blood, activate blood circulation and disperse blood clots, move back Abnormal heat and other effects, as ministerial drug.

Dittany bark: the skin of Rutaceae herbaceos perennial dittany, bitter is cold in nature, there is heat-clearing and damp-drying drug, the function of detoxifying and relieving itching Effect, as adjutant.

Rhizoma Chuanxiong: the dry rhizome of umbelliferae Rhizoma Chuanxiong, acrid flavour is warm-natured, has promote breath and open depression, and it is wet to dispel wind-dryness, promoting blood circulation The effect of analgesic, as adjutant.

Radix saposhnikoviae: the root of umbelliferae Saposhnikovia divaricata, acrid flavour, sweet, slightly warm in nature expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion, as assistant Medicine.

Tribulus terrestris: zygophyllaceae is annual or the ripening fruits of herbaceos perennial puncture vine, bitter, pungent, mild-natured, is used for liver Positive dizziness and headache, liver-depressed hypochondrium pain, headache due to pathogenic wind-heat, red eye, swell pain, the diseases such as pruitus, as making medicine.

Prepared fleece flower root: the dried root of polygonum multiflorum thunb, it is bitter, sweet, puckery, it is warm-natured, there is nourishing liver and kidney, benefiting essence-blood, Black beard and hair, strengthening the bones and muscles effect, as making medicine.

Psoralea corylifolia: fruit medicine, it is bitter, pungent, it is warm-natured, have a function of tonifying kidney and strengthening yang, good efficacy to suffering from a deficiency of the kidney, and can curing vitiligo, The skin diseases such as psoriasis, as making medicine.

Mustine hydrochlcride: chemical name is N- methyl-N- (2- chloroethyl) -2-chloroethyl amine hydrochloride, and white powder adapts to Disease is leucoderma.

By integrative therapy leucoderma, psoriasis, chronic eczema, sweat stain curative effect drug outstanding and method united application, Method preferably to improve therapeutic effect, the as composite treatment of the combination of Chinese tradiational and Western medicine.

It is many to treat leucoderma, psoriasis, chronic eczema, sweat stain curative effect drug outstanding, chemical reagent and method, every kind Therapeutic agent and method have certain curative effect, but there is also some shortcomingss, and it is undesirable, invalid, very curative effect usually occur The phenomenon that aggravation.A certain drug is used alone and method curative effect is undesirable, needs the combination of Chinese tradiational and Western medicine, complex treatment, It can be only achieved the dreamboat for the treatment of both manifestation and root cause of disease.

The beneficial effects of the present invention are:

(1) present invention is studied through secondary Chinese medicine screenings up to a hundred and composite test simultaneously according to stringent monarch compatibility relationship Above-mentioned Chinese medicine preparation is obtained, and chemical reagent hydrochloric acid mustargen is cooperateed with to obtain pharmaceutical composition through scientific matching；The pharmaceutical composition The composite treatment of the combination of Chinese tradiational and Western medicine has been adhered to, the treatment of leucoderma, psoriasis, chronic eczema, sweat stain can be used for simultaneously, and Significant in efficacy, recurrence rate is low, without side-effects.

(2) inventor is during recipe improvement, and discovery beyond expectation is by chemical reagent mustine hydrochlcride and above-mentioned Chinese medicine Therapeutic effect can be significantly improved after being formulated combined utilization, substantially reduces treatment cycle, and overcomes and hydrochloric acid nitrogen is used alone Side effect existing for mustard is more, easy to recur and slowly effective, problem that administration time is long existing for Chinese medicine preparation is used alone.

(3) pharmaceutical composition of the present invention treats leucoderma, psoriasis, chronic eczema, sweat stain by external application mode, avoids Problem more than side effect existing for endo-medicine, and easy to use, it is significant in efficacy, to mitigate leucoderma, psoriasis, slow Property eczema, sweat stain on the unfavorable body and mind of patient's bring influence.

Specific embodiment:

In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below Specific embodiment is closed, the present invention is further explained.

Embodiment

The preparation of pharmaceutical composition: by 50g Radix Rehmanniae pornographic movie, 50g radix scrophulariae, 50g kuh-seng, 50g cortex moutan, 50g dittany bark, 50g Rhizoma Chuanxiong, 50g radix saposhnikoviae, 50g tribulus terrestris, 50g prepared fleece flower root piece, 50g psoralea corylifolia 75% alcohol of 22L impregnate for 24 hours, impregnate knot 20L solution is filtered out after beam, and 10g mustine hydrochlcride is added into solution, is uniformly mixed.

Reference examples 1

The preparation of pharmaceutical composition: by 50g Radix Rehmanniae pornographic movie, 50g radix scrophulariae, 50g kuh-seng, 50g cortex moutan, 50g dittany bark, 50g Rhizoma Chuanxiong, 50g radix saposhnikoviae, 50g tribulus terrestris, 50g prepared fleece flower root piece, 50g psoralea corylifolia 75% alcohol of 22L impregnate for 24 hours, impregnate knot 20L solution is filtered out after beam.

Reference examples 2

10g mustine hydrochlcride is dissolved in 75% alcohol of 20L.

The test of animal acute skin irritation is carried out to the made drug of embodiment, test method is as follows:

100 weight are chosen in the small white mouse of 100-150g, small white mouse back backbone diamond wool is cut, takes implementation respectively The made drug of example is coated on the side skin that small white mouse is cut, and other side skin observes the skin in small white mouse 72h as control Variation.

Above-mentioned test result shows that skin adverse reaction does not occur in the made drug of embodiment.

Clinical efficacy test is carried out to above-mentioned made drug, test method is as follows:

Test object: it chooses with leucoderma, psoriasis, chronic eczema, patient each 300 of sweat stain, totally 1200, male Female is fifty-fifty, and patients with vitiligo stochastic averagina is divided into tri- groups of A1, B1, C1, and psoriatic's stochastic averagina is divided into tri- groups of A2, B2, C2, Patients with chronic eczema stochastic averagina is divided into tri- groups of A3, B3, C3, and sweat stain patient's stochastic averagina is divided into tri- groups of A4, B4, C4.A1,A2, The made drug of A3, A4 group external application embodiment, the made drug of B1, B2, B3, B4 group external application reference examples 1, C1, C2, C3, C4 group external application The made drug of reference examples 2.

Usage and dosage: being applied to affected part sooner or later daily, and dosage is every cm²Smear 0.5mL in affected part.It was 1 treatment with 1 month Journey, patients with vitiligo use 6 courses for the treatment of, and psoriasis, chronic eczema, sweat stain patient use 3 courses for the treatment of.

Curative effect is tracked and recorded, and statistical result is as shown in table 1.

Recovery from illness: illness completely disappears；Effective: illness disappears substantially；Effective: illness makes moderate progress；Invalid: illness does not become Change.

The made pharmaceutical composition of 1 embodiment of table is to leucoderma, psoriasis, chronic eczema, the curative effect of sweat stain

As shown in Table 1, embodiment is significantly improved by Chinese medicine preparation and being used in combination for mustine hydrochlcride to leucoderma, ox Psoriasis, chronic eczema, the therapeutic effect of sweat stain, and therapeutic effect be substantially better than Chinese medicine preparation, Western medicine be used alone when control Therapeutic effect.

Typical case:

1, Mr. Wang, female, 24 years old, the course of disease 2 years, the general hair property progressive stage leucoderma of vulgaris, hickie is general to be sent out, is symmetrical, with vexed Insomnia, irregular menstruation.There is large stretch of uniform melanotic macules regeneration on the crown after treatment 42 days, and hickie edge also regenerates intensive sheet Melanotic macules；Rehabilitation after treatment 09 days 4 months, melanotic macules expand fusion, and hickie disappears, and follow-up 3 years without recurrence.

2, Wu, male, 45 years old, the course of disease 9 years, the general hair property progressive stage leucoderma of vulgaris, patient was physically weak, and hickie is general to be sent out, is right Claim, with dizziness and tinnitus, insomnia, soreness and weakness of waist and knees.Hickie edge forms in white and black boundary after treatment 42 days, and hickie becomes light red Color, local hickie have uniformly intensive melanocyte point regeneration；Rehabilitation after treatment 0 27 days 10 months, white patch on the face disappear substantially, with 3 years are visited without recurrence.

3, Sun, male, 36 years old, 5-year courses, two leg many places were with psoriasis；Rehabilitation after treatment 08 days 2 months, follow-up three Year is without recurrence.

4, Lee, female 51 years old, the course of disease 3 years, cover with psoriasis below knee；Rehabilitation after treatment 23 days 1 month, follow-up three Year is without recurrence.

5, China certain, female, 12 years old, the course of disease 4 years, there is fash in every spring, winter recurrence, trick portion, dry peeling of itching, scratching Occurs red dermatograph afterwards；Rehabilitation after treatment 10 days 1 month, follow-up 3 years without recurrence.

6, Wang, male, 26 years old, the course of disease 8 years, recurrent exerbation, there is skin after scratching in skin of leg itch, drying, Scaling Rash, pachyderma angling at the skin lesion of recurrent exerbation；Rehabilitation after treatment 08 days 2 months, follow-up 3 years without recurrence.

7, Mr. Wang, male, 34 years old, the course of disease 3 years, there is multiple tinea versicolor, clear-cut margin in chest, back, neck, and painless nothing is itched, Side sees that skin lesion surface reflection is strong；Rehabilitation after treatment 13 days 2 months, follow-up 3 years without recurrence.

8, Liu, female, 28 years old, the course of disease 1 year, there is round macula in body many places, and clear-cut margin maintains an equal level with skin, surface In the scales of skin that peel off；Rehabilitation after treatment 25 days 1 month, follow-up 3 years without recurrence.

The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent thereof.

Claims

1. a kind of treat leucoderma, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain, it is characterised in that: by following weight Drug is made:

Radix Rehmanniae pornographic movie 50g, radix scrophulariae 50g, kuh-seng 50g, cortex moutan 50g, dittany bark 50g, Rhizoma Chuanxiong 50g, radix saposhnikoviae 50g, tribulus terrestris 50g, prepared fleece flower root piece 50g, psoralea corylifolia 50g, mustine hydrochlcride 10g.

2. treatment leucoderma according to claim 1, psoriasis, chronic eczema, the pharmaceutical composition of sweat stain, feature exist In: described pharmaceutical composition the preparation method comprises the following steps: by Radix Rehmanniae pornographic movie, radix scrophulariae, kuh-seng, cortex moutan, dittany bark, Rhizoma Chuanxiong, radix saposhnikoviae, white Puncture vine, prepared fleece flower root piece, psoralea corylifolia are impregnated with 75% alcohol, solution are filtered out after immersion, and hydrochloric acid is added into solution Mustargen is uniformly mixed.