CN105343381A - Plaster for treating tenosynovitis and preparation method of plaster - Google Patents

Abstract

The invention discloses a plaster for treating tenosynovitis and a preparation method of the plaster. The prepared plaster comprises raw materials as follows: shinyleaf pricklyash roots, roots of mountain spicy trees, acutangular anisodus roots, pine nodular branch, largeleaf gentian roots, stems of obtuseleaf erycibe, fortune's drynaria rhizome, Chinese alangium lateral roots, Schefflera kwangsiensis, decumbent corydalis tuber, native copper, Japanese milkwort herb, roots of lineate supplejack, trogopterus dung, beautiful sweetgum fruits, wooly datchmanspipe herb, Chinese aralis, parslane herb, aloe, blueberries, prepared liquorice, laurocapram, squalane, propolis, chamomile essential oil and dicyano isobutyl acrylate. The plaster adopts a pure traditional Chinese medicine preparation, can directly act on a wounded part for a long time, can quickly relieve uncomfortable symptoms such as swelling and the like on the wounded part and treats both symptoms and root causes, the formula is mild and safe and does not have side effects, tenosynovitis cannot relapse after being cured, medicine resistance cannot be caused, and the curative effect is remarkable.

Description

A kind of plaster for the treatment of tenosynovitis and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind of plaster for the treatment of tenosynovitis and preparation method thereof.

Background technology

Stndon sheath is exactly be enclosed within the airtight synovial membrane pipe of bilayer sleeve sample outside tendon, is the vagina synovialis of protection tendon.It is point two-layer surrounds tendon, and a cavity and Synovial cavity between two-layer, inside have stndon sheath synovial fluid.Internal layer and tendon are closely affixed, and skin is lining in inside the fibrous sheath of tendon, are jointly combined with surface of bone, have fixing, protection and lubrication tendon, make its from friction or compressing effect.For a long time at this excessive friction, the damaging inflammation of tendon and stndon sheath can be there is, cause swelling, be called tenosynovitis in tendon.Tenosynovitis is one of modal disease of hands surgery, is more common in and is engaged in loaded down with trivial details daily housework activist and the professional population of long-term repetitive strain injury.Modal two types of tenosynovitis are de Quervain disease and tenovaginitis of flexor digitorum.Doctor trained in Western medicine thinks that primary disease is many because joint is when long-term Overexertion and excessive amount of motion, rub between tendon and stndon sheath, cause stndon sheath hyperemia, edema and ooze out and increase, delay with the passing of time, there is chronic connective tissue proliferation, plumpness in tendon and stndon sheath, granulation tissue is formed, the pathological change such as hyalinosis and adhesion.At present, doctor trained in Western medicine adopts symptomatic treatment, block therapy or operative therapy mostly, and how undesirable curative effect is, easy recurrent exerbation, or has comparatively major injury to local organization.Compared to western medicine therapy, tcm therapy is gentleer, less to patient's injury, and the traditional Chinese medical science is by this sick ownership " muscle and tendon injury " " muscular rheumatism " category, think its morbidity mainly because work is usually excessive, muscle arteries and veins is impaired, redyes again wind, cold, wet heresy, cause QI and blood block, passages through which vital energy circulates lose support caused by, Chinese traditional treatment many employings hot compress, acupuncture, massage, with blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain for Therapeutic Principle, but to there is the course for the treatment of long more, the shortcoming that onset is slow.

Summary of the invention

The object of the invention is to overcome the deficiencies in the prior art, a kind of plaster for the treatment of tenosynovitis and preparation method thereof is provided, adopt pure Chinese medicinal preparation, direct long duration of action is in affected part, and the malaise symptoms such as swell and ache in rapid recovery affected part, this disease for the treatment of both the principal and secondary aspects of a disease, the gentle safety of formula has no side effect, more not easily recur after, and can not drug resistance be produced, evident in efficacy.

A kind of plaster for the treatment of tenosynovitis, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 15-20 part, Radix Litseae 8-10 part, Radix Anisodi Acutanguli 4-6 part, Pine Nodular Branch 6-8 part, Radix Gentianae Macrophyllae 2-4 part, Caulis Erycibes 6-8 part, Rhizoma Drynariae 6-8 part, Radix Alangii side root 1-2 part, Radix Schefflerae Arboricolae 8-12 part, Rhizoma Corydalis Decumbentis 6-10 part, Pyritum 1-2 part, Semen Caesalpiniae Minacis 4-6 part, Herba Polygalae Japonicae 3-5 part, Radix berchemiae lineatae 1-3 part, Oletum Trogopterori 3-5 part, Fructus Liquidambaris 5-7 part, Herba Aristolochiae Mollissimae 6-8 part, Cortex araliae chinensis 4-6 part, Herba Portulacae 8-12 part, Aloe 6-10 part, blue berry 8-12 part, Radix Glycyrrhizae Preparata 3-5 part, laurocapram 8-15 part, squalane 6-9 part, propolis 8-13 part, chamomile essential oil 6-8 part, dicyano Isobutyl 2-propenoate 1-3 part.

Preferably, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 15 parts, Radix Litseae 8 parts, Radix Anisodi Acutanguli 4 parts, Pine Nodular Branch 6 parts, Radix Gentianae Macrophyllae 2 parts, Caulis Erycibes 6 parts, Rhizoma Drynariae 6 parts, Radix Alangii side root 1 part, Radix Schefflerae Arboricolae 8 parts, Rhizoma Corydalis Decumbentis 6 parts, Pyritum 1 part, Semen Caesalpiniae Minacis 4 parts, Herba Polygalae Japonicae 3 parts, Radix berchemiae lineatae 1 part, Oletum Trogopterori 3 parts, Fructus Liquidambaris 5 parts, Herba Aristolochiae Mollissimae 6 parts, Cortex araliae chinensis 4 parts, Herba Portulacae 8 parts, Aloe 6 parts, blue berry 8 parts, Radix Glycyrrhizae Preparata 3 parts, laurocapram 8 parts, squalane 6 parts, propolis 8 parts, chamomile essential oil 6 parts, dicyano Isobutyl 2-propenoate 1 part.

Preferably, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 17 parts, Radix Litseae 9 parts, Radix Anisodi Acutanguli 5 parts, Pine Nodular Branch 7 parts, Radix Gentianae Macrophyllae 3 parts, Caulis Erycibes 7 parts, Rhizoma Drynariae 7 parts, Radix Alangii side root 1.5 parts, Radix Schefflerae Arboricolae 10 parts, Rhizoma Corydalis Decumbentis 8 parts, Pyritum 1.5 parts, Semen Caesalpiniae Minacis 5 parts, Herba Polygalae Japonicae 4 parts, Radix berchemiae lineatae 2 parts, Oletum Trogopterori 4 parts, Fructus Liquidambaris 6 parts, Herba Aristolochiae Mollissimae 7 parts, Cortex araliae chinensis 5 parts, Herba Portulacae 10 parts, Aloe 8 parts, blue berry 10 parts, Radix Glycyrrhizae Preparata 4 parts, laurocapram 11 parts, squalane 7 parts, propolis 10 parts, chamomile essential oil 7 parts, dicyano Isobutyl 2-propenoate 2 parts.

Preferably, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 20 parts, Radix Litseae 10 parts, Radix Anisodi Acutanguli 6 parts, Pine Nodular Branch 8 parts, Radix Gentianae Macrophyllae 4 parts, Caulis Erycibes 8 parts, Rhizoma Drynariae 8 parts, Radix Alangii side root 2 parts, Radix Schefflerae Arboricolae 12 parts, Rhizoma Corydalis Decumbentis 10 parts, Pyritum 2 parts, Semen Caesalpiniae Minacis 6 parts, Herba Polygalae Japonicae 5 parts, Radix berchemiae lineatae 3 parts, Oletum Trogopterori 5 parts, Fructus Liquidambaris 7 parts, Herba Aristolochiae Mollissimae 8 parts, Cortex araliae chinensis 6 parts, Herba Portulacae 12 parts, Aloe 10 parts, blue berry 12 parts, Radix Glycyrrhizae Preparata 5 parts, laurocapram 15 parts, squalane 9 parts, propolis 13 parts, chamomile essential oil 8 parts, dicyano Isobutyl 2-propenoate 3 parts.

The invention also discloses the preparation method of the plaster of described treatment tenosynovitis, it is characterized in that: comprise the following steps:

(1) Radix Litseae, Radix Anisodi Acutanguli, Pine Nodular Branch, Radix Gentianae Macrophyllae, Radix Alangii side root, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Pyritum, Semen Caesalpiniae Minacis, Herba Polygalae Japonicae, Radix berchemiae lineatae, Oletum Trogopterori, Fructus Liquidambaris, Herba Aristolochiae Mollissimae, Cortex araliae chinensis, Radix Glycyrrhizae Preparata are crushed to 50 order Chinese medicine coarse powder;

(2) step (1) gained Chinese medicine coarse powder adds the water soaking 1 hour of gross mass multiple 4 times, slow fire boiling 2 hours, and crossing 500 order drainage screens after decocting, to obtain filtrate for subsequent use;

(3) Radix Zanthoxyli, Caulis Erycibes, Rhizoma Drynariae super micron mill are pulverized, and cross 1000 mesh sieves and obtain mixed-powder, for subsequent use;

(4) Herba Portulacae fresh goods, Aloe fresh goods, blueberry fresh fruit mixing are cleaned, add after the mixing of step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 200 order filter screen filtration, gained filtrate adds in low-temperature vacuum thickener, and cryoconcentration (less than 40 DEG C) to relative density is the thick paste of 1.30 ± 0.02 (30 DEG C);

(5) by after squalane, propolis heating and melting, continuous stirring, add laurocapram, chamomile essential oil and dicyano Isobutyl 2-propenoate, when temperature is down to 50 DEG C, add the thick paste that step (4) is obtained, mixing, then add the mixed-powder that step (3) is obtained, stirring and evenly mixing, make cream core, and be placed on sticker, obtain the plaster of described treatment tenosynovitis.

To achieve these goals, technical scheme provided by the invention is as follows:

The traditional Chinese medical science is thought, the morbidity of tenosynovitis is mainly because work is usually excessive, muscle arteries and veins is impaired, redye wind again, cold, damp, QI and blood is caused to block, caused by passages through which vital energy circulates mistake is supported, the invention discloses a kind of external plaster that can directly act on affected part for a long time, this plaster is for the inherent cause of disease of this disease and external disease, and external preparation directly acts on affected part and easily causes skin sensitivity to affect the problem of skin health, take expelling wind and cold, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain, the method of Shu Min granulation promoting, according to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, raw material of Chinese medicine is screened by great many of experiments, refining agent method, each efficacy of drugs is made to produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.Specifically, in the crude drug chosen:

Radix Zanthoxyli: property is put down, bitter in the mouth, pungent, promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, with controlling injury from falling down that qi depression to blood stasis causes, rheumatic arthralgia, stomachache, toothache, venom, the burning hot wound of external treatment soup;

Radix Litseae: acrid in the mouth, hardship, warm in nature, expelling wind and removing dampness, warming spleen and stomach for dispelling cold, promoting flow of QI and blood, for the distension and fullness in the abdomen that cold, edema beriberi, anemofrigid-damp arthralgia, puerperal abdonimal pain, dysmenorrhea due to blood stasis, the stagnation of QI are trembled with fear;

Radix Anisodi Acutanguli: warm in nature, bitter in the mouth, pungent, spasmolysis and analgesia, expelling wind and removing dampness, with treating for stomachache, gallbladder, kidney, intestinal colic, Fengshi Guanjie pain, lumbago and skelalgia, traumatic injury;

Pine Nodular Branch: warm in nature, bitter in the mouth, pungent, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, with controlling anemofrigid-damp arthralgia, severe and migratory arthralgia pain, convulsion contraction is anxious, traumatic pain;

Radix Gentianae Macrophyllae: property is put down, bitter in the mouth, pungent, and wind-damp dispelling, reducing the asthenic fever, relaxing muscles and tendons relieve the pain, the diseases such as treatment rheumatic arthritis, the contracture of muscle arteries and veins, tuberculosis hectic fever, infantile malnutrition heating, jaundice, dysuria, treat arthralgia, headache, toothache etc.;

Caulis Erycibes: warm in nature, acrid in the mouth, expelling wind and removing dampness, reducing swelling and alleviating pain, belong to the wind-damp-dispelling and cold-dissipating medicinal of medicine for rheumatism subordinate classification, Erycib alkaloid II tool anti-inflammatory and analgesic effect, and energy spasmolytic; The myosis of Caulis Erycibes A prime tool, reducing iop, and have cardiotonic, clinical in controlling the diseases such as chronic rheumatic arthritis, glaucoma, various pain;

Radix Alangii side root: acrid in the mouth, hardship, warm in nature, expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, eliminating stasis to stop pain, with controlling numb limbs and tense tendons, injury from falling down;

Rhizoma Drynariae: warm in nature, bitter in the mouth, continues and hinders pain relieving, the kidney invigorating bone strengthening, with controlling lumbago due to renal deficiency, toothache, tinnitus, chronic diarrhea, traumatic injury, alopecia areata, clavus etc.;

Radix Schefflerae Arboricolae: warm in nature, mildly bitter flavor, puckery, wind-expelling pain-stopping, relaxing muscles and tendons and activating QI and blood in the collateral, with controlling trigeminal neuralgia, nervous headache, sciatica, rheumatic arthritis, stomachache, intestinal and biliary tract pain, injury and bone fracture and traumatic hemorrhage etc.;

Rhizoma Corydalis Decumbentis: warm in nature, bitter in the mouth, micro-pungent, to invigorate blood circulation, dredging collateral, promoting the circulation of QI to relieve pain, with controlling apoplectic hemiplegia, poliomyelitis sequela, sciatica, rheumatic arthritis, traumatic injury, lumbar muscle strain etc.;

Pyritum: property is put down, acrid in the mouth, dissipating blood stasis, synthetism, pain relieving, with controlling tumbling and swelling, injured bone;

Semen Caesalpiniae Minacis: property is bitter, taste is trembled with fear, and dissipating blood stasis, pain relieving, heat clearing away, dries, with controlling hiccup, dysentery, stranguria with turbid discharge, hematuria, traumatic injury;

Herba Polygalae Japonicae: property is put down, acrid in the mouth, hardship, expelling phlegm for arresting cough, promoting blood circulation and detumescence, removing toxic substances pain relieving, with controlling cough with copious phlegm, laryngopharynx swelling and pain, external treatment traumatic injury, treats furuncle and swells, snake bite and insect sting;

Radix berchemiae lineatae: property is put down, sweet in the mouth, light, puckery, the cough-relieving of reason lung, stasis-dispelling and pain-killing, soothing liver-QI jaundice eliminating, stomach invigorating removing food stagnancy, spit blood for impairment caused by overstrain, taste-blindness rate is hemorrhage, schizophrenia, traumatic injury, rheumatic ostalgia, furuncle furuncle and phyma, deradenoncus, painful and swollen testis;

Oletum Trogopterori: warm in nature, salty in the mouth, sweet, promoting blood circulation and stopping pain, removing stasis to stop bleeding, removing food stagnancy detoxify, with controlling all pains of trusted subordinate's vim and vigour, women's amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, metrostaxis, infantile malnutrition; External treatment Serpentis, scorpion, centipete bite;

Fructus Liquidambaris: property is put down, bitter in the mouth, dispelling, collateral-activating, and diuretic stimulates the menstrual flow, with controlling arthralgia, numbness contracture, edema distension, the few amenorrhea of breast;

Herba Aristolochiae Mollissimae: property is put down, acrid in the mouth, hardship, and dispelling wind and removing obstruction in the collateral, promoting the circulation of QI to relieve pain, with dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, muscles and bones contracture, traumatic injury pain, stomachache, toothache, colic etc.;

Cortex araliae chinensis: sweet in the mouth, micro-hardship, property is put down, and wind-damp dispelling, diuresis, dissipating blood stasis blood, detumescence poison, with controlling lumbar muscle strain, ascites, gastropathy, osteomyelitis, acute or chronic hepatitis etc.;

Herba Portulacae: cold in nature, sweet in the mouth acid, enter the heart, liver, spleen, large intestine channel, have that removing dampness is antipruritic, clearing heat for detumescence, heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood.Herba Portulacae is to dysentery bacterium, Bacillus typhi and escherichia coli have stronger inhibitory action, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ", Herba Portulacae is also rich in vitamin C simultaneously, vitamin C has good antioxidation can whitening nourishes rough skin, modern medicine finds, Herba Portulacae has higher nutritive value and medical value, except the protein containing routine, outside the nutrient such as vitamin and mineral, Herba Portulacae is also containing unique bioactive ingredients, the activity of Human Epithelial Cells can be strengthened, help lend some impetus to ulcer and healing,

Aloe: pathogenic fire purging, removing toxic substances, blood stasis dispelling, parasite killing, argument is red, constipation, nebulousurine, hematuria, pediatric epilepsy scared, infantile malnutrition, burn and scald, women's amenorrhea, hemorrhoid, scabies, carbuncle furuncle and phyma poison, traumatic injury, mucus (mucin in Aloe, be exactly protein), for nucleus with polysaccharides such as arboranABaloemannanaloetin, mucus class material is the important component preventing cell senescence and treatment chronic allergic, mucoitin is present in the place such as muscle and gastrointestinal mucosa of human body, allow and organize high resilience, if liquid element is not enough, muscle and mucosa will lose elasticity and stiff aging, Aloin A, wound hormone and polysaccharide peptide manna (Ke-2) etc. have viral infection resisting, promote the effect that wound healing restores, there is anti-inflammation and sterilization, heat absorption detumescence, softening skin, keep the function of cell viability, curdlan is combined with 1-decene-1 and is also had healing wounds activity,

Chamomile essential oil: acne, allergy, eczema, burn and scald can be improved; can say it is to one of best hydrosol of skin; there is antiinflammatory and pacify characteristic; for responsive and acne vulgaris skin; fabulous to dryness, sensitive skin, there is good effect to treatment pimples, herpes, eczema, tinea, microvascular, can be used for the eye skin protecting face the most responsive; for treatment acne vulgaris and red seal Be very effective, increase skin resistance.

Blue berry: containing abundant nutritional labeling in fruit, have prevent that cranial nerve is aging, vision protection, heart tonifying, anticancer, vessel softening, the function such as enhancing human organism immunity, nutritional labeling is high, it is a kind of strong antioxidant that blue berry is rich in anthocyanidin glycoside, it can protect human body from the damage of free radical, anthocyanidin glycoside can also strengthen blood vessel elasticity, improve the smoothness of blood circulation and enhancement skin, inflammation-inhibiting and allergy, vitamin C in blue berry is one of antioxidant vitamins, can effective scavenging free radicals, prevent skin aging;

Radix Glycyrrhizae Preparata: containing number of chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, there is antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect, therefore the primary efficacy of Radix Glycyrrhizae Preparata is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.

In all medicines, Radix Zanthoxyli is monarch drug, plays the effect of expelling wind and cold, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain, for this disease of cause of disease treatment for diseases.Radix Litseae, Radix Anisodi Acutanguli, Pine Nodular Branch, Radix Gentianae Macrophyllae, Caulis Erycibes, Rhizoma Drynariae, Radix Alangii side root, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Pyritum, Semen Caesalpiniae Minacis, Herba Polygalae Japonicae, Radix berchemiae lineatae, Oletum Trogopterori, Fructus Liquidambaris, Herba Aristolochiae Mollissimae, Cortex araliae chinensis are ministerial drug, gain monarch drug drug effect, wherein, Radix Litseae, Radix Anisodi Acutanguli, Pine Nodular Branch, Radix Gentianae Macrophyllae, Caulis Erycibes, Radix Alangii side root, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Fructus Liquidambaris, Herba Aristolochiae Mollissimae, Cortex araliae chinensis can remove the effect of expelling wind and cold by gain monarch drug, directly act on affected part, effectively dispel affected part wind-cold damp pathogen, the effect of Radix Litseae, Radix Gentianae Macrophyllae, Radix Alangii side root, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Herba Polygalae Japonicae, Oletum Trogopterori, all right gain monarch drug relaxing muscles and tendons to promote blood circulation of Fructus Liquidambaris, the cause of disease of supporting is lost in the retardance of effective remissive treatment affected part QI and blood, passages through which vital energy circulates, Radix Anisodi Acutanguli, Pine Nodular Branch, Radix Gentianae Macrophyllae, Radix Alangii side root Rhizoma Drynariae, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Pyritum, Semen Caesalpiniae Minacis, Herba Polygalae Japonicae, Radix berchemiae lineatae, Herba Aristolochiae Mollissimae, Cortex araliae chinensis have the effect of reducing swelling and alleviating pain, can swell and ache in rapid recovery affected part, eliminate patient suffering, in ministerial drug, Radix Anisodi Acutanguli and Oleum Terebinthinae all can actual gain monarch drug drug effects, but the alkaloid component contained by Radix Anisodi Acutanguli, and the Camphor tree alkene contained by Oleum Terebinthinae, cinene all easily causes skin allergy symptom, and life-time service topical agent is also easy damages skin, make dull-looking skin coarse, in order to alleviate these side effect, the present invention is with Herba Portulacae, Aloe, chamomile essential oil, blue berry is assistant, play the effect of Shu Min granulation promoting, available protecting nourishes illing skin, prevention skin allergy, wherein, it is a kind of strong antioxidant that blue berry is rich in anthocyanidin glycoside, it can protect human body from the damage of free radical, anthocyanidin glycoside can also strengthen blood vessel elasticity, improve the smoothness of blood circulation and enhancement skin, inflammation-inhibiting and allergy, vitamin C in blue berry is one of antioxidant vitamins, can effective scavenging free radicals, prevent skin aging, Herba Portulacae, Aloe also has good analgesic effect, can the effect of reducing swelling and alleviating pain of gain monarch drug ministerial drug.Radix Glycyrrhizae Preparata, for making, plays harmonizing yingfen and weifen, the effect of warming spleen and stomach for dispelling cold.Plaster of the present invention is pure Chinese medicinal preparation, selected medical material compatibility is suitable, and adopt modern advanced medical pharmaceutical technology to make, affected part can be directly acted on for a long time, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient be painful fast, not easily recur more, the remarkable advantage of safe without toxic side effect, is adapted to the treatment to tenosynovitis.

Beneficial effect of the present invention is: instant invention overcomes the deficiencies in the prior art, a kind of plaster for the treatment of tenosynovitis and preparation method thereof is provided, adopt pure Chinese medicinal preparation, can directly act on affected part for a long time, the malaise symptoms such as swell and ache in rapid recovery affected part, this disease for the treatment of both the principal and secondary aspects of a disease, the gentle safety of formula has no side effect, more not easily recur after, and can not drug resistance be produced, evident in efficacy.This plaster for work excessively, muscle arteries and veins is impaired, redye wind again, cold, damp, QI and blood is caused to block, passages through which vital energy circulates loses the cause of disease of supporting, take expelling wind and cold, the method of relaxing muscles and tendons to promote blood circulation is for this disease of etiological treatment, can effectively reducing swelling and alleviating pain reduction of patient be painful, simultaneously, skin allergy is caused in order to prevent the allergen in raw material, make dull-looking skin coarse, the present invention is with Herba Portulacae, Aloe, chamomile essential oil, blue berry is assistant, play the effect of Shu Min granulation promoting, available protecting nourishes illing skin, prevention skin allergy, wherein, it is a kind of strong antioxidant that blue berry is rich in anthocyanidin glycoside, it can protect human body from the damage of free radical, anthocyanidin glycoside can also strengthen blood vessel elasticity, improve the smoothness of blood circulation and enhancement skin, inflammation-inhibiting and allergy, vitamin C in blue berry is one of antioxidant vitamins, can effective scavenging free radicals, prevent skin aging, compatibility of drugs is proper, all medicines are nursed one's health mutually, body is had no adverse effects, apply safer.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

A kind of plaster for the treatment of tenosynovitis, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 15 parts, Radix Litseae 8 parts, Radix Anisodi Acutanguli 4 parts, Pine Nodular Branch 6 parts, Radix Gentianae Macrophyllae 2 parts, Caulis Erycibes 6 parts, Rhizoma Drynariae 6 parts, Radix Alangii side root 1 part, Radix Schefflerae Arboricolae 8 parts, Rhizoma Corydalis Decumbentis 6 parts, Pyritum 1 part, Semen Caesalpiniae Minacis 4 parts, Herba Polygalae Japonicae 3 parts, Radix berchemiae lineatae 1 part, Oletum Trogopterori 3 parts, Fructus Liquidambaris 5 parts, Herba Aristolochiae Mollissimae 6 parts, Cortex araliae chinensis 4 parts, Herba Portulacae 8 parts, Aloe 6 parts, blue berry 8 parts, Radix Glycyrrhizae Preparata 3 parts, laurocapram 8 parts, squalane 6 parts, propolis 8 parts, chamomile essential oil 6 parts, dicyano Isobutyl 2-propenoate 1 part.

The preparation method of described plaster, comprises the following steps:

(1) Radix Litseae, Radix Anisodi Acutanguli, Pine Nodular Branch, Radix Gentianae Macrophyllae, Radix Alangii side root, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Pyritum, Semen Caesalpiniae Minacis, Herba Polygalae Japonicae, Radix berchemiae lineatae, Oletum Trogopterori, Fructus Liquidambaris, Herba Aristolochiae Mollissimae, Cortex araliae chinensis, Radix Glycyrrhizae Preparata are crushed to 50 order Chinese medicine coarse powder;

(2) step (1) gained Chinese medicine coarse powder adds the water soaking 1 hour of gross mass multiple 4 times, slow fire boiling 2 hours, and crossing 500 order drainage screens after decocting, to obtain filtrate for subsequent use;

(3) Radix Zanthoxyli, Caulis Erycibes, Rhizoma Drynariae super micron mill are pulverized, and cross 1000 mesh sieves and obtain mixed-powder, for subsequent use;

(4) Herba Portulacae fresh goods, Aloe fresh goods, blueberry fresh fruit mixing are cleaned, add after the mixing of step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 200 order filter screen filtration, gained filtrate adds in low-temperature vacuum thickener, and cryoconcentration (less than 40 DEG C) to relative density is the thick paste of 1.30 ± 0.02 (30 DEG C);

(5) by after squalane, propolis heating and melting, continuous stirring, add laurocapram, chamomile essential oil and dicyano Isobutyl 2-propenoate, when temperature is down to 50 DEG C, add the thick paste that step (4) is obtained, mixing, then add the mixed-powder that step (3) is obtained, stirring and evenly mixing, make cream core, and be placed on sticker, obtain the plaster of described treatment migratory arthralgia.

Using method: clean affected part skin, keep dry, then the plaster of the present embodiment is affixed on affected part, and press gently with palm, 8-12 as a child tore, after 8 hours, again paste portion, and operation is with first time.

Embodiment 2

A kind of plaster for the treatment of tenosynovitis, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 17 parts, Radix Litseae 9 parts, Radix Anisodi Acutanguli 5 parts, Pine Nodular Branch 7 parts, Radix Gentianae Macrophyllae 3 parts, Caulis Erycibes 7 parts, Rhizoma Drynariae 7 parts, Radix Alangii side root 1.5 parts, Radix Schefflerae Arboricolae 10 parts, Rhizoma Corydalis Decumbentis 8 parts, Pyritum 1.5 parts, Semen Caesalpiniae Minacis 5 parts, Herba Polygalae Japonicae 4 parts, Radix berchemiae lineatae 2 parts, Oletum Trogopterori 4 parts, Fructus Liquidambaris 6 parts, Herba Aristolochiae Mollissimae 7 parts, Cortex araliae chinensis 5 parts, Herba Portulacae 10 parts, Aloe 8 parts, blue berry 10 parts, Radix Glycyrrhizae Preparata 4 parts, laurocapram 11 parts, squalane 7 parts, propolis 10 parts, chamomile essential oil 7 parts, dicyano Isobutyl 2-propenoate 2 parts.

The preparation method of the plaster of embodiment 2 is identical with embodiment 1 with using method.

Embodiment 3

A kind of plaster for the treatment of tenosynovitis, crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 20 parts, Radix Litseae 10 parts, Radix Anisodi Acutanguli 6 parts, Pine Nodular Branch 8 parts, Radix Gentianae Macrophyllae 4 parts, Caulis Erycibes 8 parts, Rhizoma Drynariae 8 parts, Radix Alangii side root 2 parts, Radix Schefflerae Arboricolae 12 parts, Rhizoma Corydalis Decumbentis 10 parts, Pyritum 2 parts, Semen Caesalpiniae Minacis 6 parts, Herba Polygalae Japonicae 5 parts, Radix berchemiae lineatae 3 parts, Oletum Trogopterori 5 parts, Fructus Liquidambaris 7 parts, Herba Aristolochiae Mollissimae 8 parts, Cortex araliae chinensis 6 parts, Herba Portulacae 12 parts, Aloe 10 parts, blue berry 12 parts, Radix Glycyrrhizae Preparata 5 parts, laurocapram 15 parts, squalane 9 parts, propolis 13 parts, chamomile essential oil 8 parts, dicyano Isobutyl 2-propenoate 3 parts.

The preparation method of the plaster of embodiment 3 is identical with embodiment 1 with using method.

Embodiment 4 hypersensitive test

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group and positive controls positive controls with 2 at random, 4-dinitrochlorobenzene, sensitization 1% concentration, excites and uses 0.1% concentration; The test group plaster cream core of the embodiment of the present invention 2.The plaster cream core getting the embodiment of the present invention 3 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, smear this plaster cream core at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, sensitization rate is 100%, and any symptoms of allergic does not all appear in test group and blank treated animal skin, and sensitization rate is 0%.Experimental result shows that plaster cream core formula gentleness of the present invention is non-stimulated.

Embodiment 5 clinical trial:

Random selecting 300 tenosynovitis patients carry out clinical trial, patient is divided into 3 groups at random, plaster respectively in embodiment 1 to 3 on probation treats this disease, using method is: clean affected part skin, keeps dry, then the plaster of the present embodiment is affixed on affected part, and press gently with palm, 8-12 as a child tore, after 8 hours, again paste portion, and operation is with first time.Within 10th, be a course for the treatment of, investigate the curative effect of plaster of the present invention, the evaluation criterion of curative effect is:

Cure: arthralgia disappears completely, and joint function recovery is normal;

Effective: arthralgia partial disappearance, function of joint is recovered substantially;

Invalid: arthralgia and joint function disturbance are without improvement or aggravation.

Statistical result is as follows:

	Embodiment 1	Embodiment 2	Embodiment 3
				Cure	62	71	66
Effectively	36	29	33
				Invalid	2	0	1
Effective percentage (%)	98	100	99

All patients during medication all without bad reflection, experimental result shows, the effective percentage of plaster of the present invention reaches more than 98%, energy rapid recovery patients symptomatic, evident in efficacy, can safe and effective treatment tenosynovitis, all without skin allergy symptom during patient medication, without recurrence after curing, it is desirable medicine.

Clinical exemplary embodiments:

1. Zhang, female, 29 years old, suffer from articulations digitorum manus tenosynovitis, articulations digitorum manus swelling pain unbearably, repeatedly topical remedy's closed treating, after treatment, symptom alleviates, but recurrent exerbation in the near future, use the plaster of the embodiment of the present invention 2, medication same day, patient's readme pain relief, a course for the treatment of of medication, arthralgia disappears completely, and joint function recovery is normal, and patient fully recovers, consolidate a course for the treatment of of medication, follow up a case by regular visits to and have no recurrence half a year.

2. neat so-and-so, man, 35 years old,, there is snap phenomenon in patient's both hands thumb pain, topical remedy closes and waits treatment after 1 month when counting on one's fingers, without being clearly better, use the plaster of the embodiment of the present invention 1, medication is after 2 days, patient's readme pain relief, a course for the treatment of of medication, sound of counting on one's fingers disappears, arthralgia disappears completely, and joint function recovery is normal, and patient fully recovers, consolidate a course for the treatment of of medication, follow up a case by regular visits to and have no recurrence half a year.

3. Zhang, man, 58 years old, suffer from de Quervain disease, pain around the apophysis place of right hand wrist thumb side and thumb, thumb activity is obstructed, there are tenderness and friction sense at processus styloideus radii place, have the pisiformis tuberosity of slight protuberance in processus styloideus radii, use the plaster of the embodiment of the present invention 3, medication is after 3 days, and patient's readme pain obviously alleviates, a course for the treatment of of medication, arthralgia disappears completely, and joint function recovery is normal, and patient fully recovers, consolidate medication 1 week, follow up a case by regular visits to and have no recurrence half a year.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat the plaster of tenosynovitis for one kind, it is characterized in that: crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 15-20 part, Radix Litseae 8-10 part, Radix Anisodi Acutanguli 4-6 part, Pine Nodular Branch 6-8 part, Radix Gentianae Macrophyllae 2-4 part, Caulis Erycibes 6-8 part, Rhizoma Drynariae 6-8 part, Radix Alangii side root 1-2 part, Radix Schefflerae Arboricolae 8-12 part, Rhizoma Corydalis Decumbentis 6-10 part, Pyritum 1-2 part, Semen Caesalpiniae Minacis 4-6 part, Herba Polygalae Japonicae 3-5 part, Radix berchemiae lineatae 1-3 part, Oletum Trogopterori 3-5 part, Fructus Liquidambaris 5-7 part, Herba Aristolochiae Mollissimae 6-8 part, Cortex araliae chinensis 4-6 part, Herba Portulacae 8-12 part, Aloe 6-10 part, blue berry 8-12 part, Radix Glycyrrhizae Preparata 3-5 part, laurocapram 8-15 part, squalane 6-9 part, propolis 8-13 part, chamomile essential oil 6-8 part, dicyano Isobutyl 2-propenoate 1-3 part.

2. a kind of plaster for the treatment of tenosynovitis as claimed in claim 1, it is characterized in that: crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 15 parts, Radix Litseae 8 parts, Radix Anisodi Acutanguli 4 parts, Pine Nodular Branch 6 parts, Radix Gentianae Macrophyllae 2 parts, Caulis Erycibes 6 parts, Rhizoma Drynariae 6 parts, Radix Alangii side root 1 part, Radix Schefflerae Arboricolae 8 parts, Rhizoma Corydalis Decumbentis 6 parts, Pyritum 1 part, Semen Caesalpiniae Minacis 4 parts, Herba Polygalae Japonicae 3 parts, Radix berchemiae lineatae 1 part, Oletum Trogopterori 3 parts, Fructus Liquidambaris 5 parts, Herba Aristolochiae Mollissimae 6 parts, Cortex araliae chinensis 4 parts, Herba Portulacae 8 parts, Aloe 6 parts, blue berry 8 parts, Radix Glycyrrhizae Preparata 3 parts, laurocapram 8 parts, squalane 6 parts, propolis 8 parts, chamomile essential oil 6 parts, dicyano Isobutyl 2-propenoate 1 part.

3. a kind of plaster for the treatment of tenosynovitis as claimed in claim 1, it is characterized in that: crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 17 parts, Radix Litseae 9 parts, Radix Anisodi Acutanguli 5 parts, Pine Nodular Branch 7 parts, Radix Gentianae Macrophyllae 3 parts, Caulis Erycibes 7 parts, Rhizoma Drynariae 7 parts, Radix Alangii side root 1.5 parts, Radix Schefflerae Arboricolae 10 parts, Rhizoma Corydalis Decumbentis 8 parts, Pyritum 1.5 parts, Semen Caesalpiniae Minacis 5 parts, Herba Polygalae Japonicae 4 parts, Radix berchemiae lineatae 2 parts, Oletum Trogopterori 4 parts, Fructus Liquidambaris 6 parts, Herba Aristolochiae Mollissimae 7 parts, Cortex araliae chinensis 5 parts, Herba Portulacae 10 parts, Aloe 8 parts, blue berry 10 parts, Radix Glycyrrhizae Preparata 4 parts, laurocapram 11 parts, squalane 7 parts, propolis 10 parts, chamomile essential oil 7 parts, dicyano Isobutyl 2-propenoate 2 parts.

4. a kind of plaster for the treatment of tenosynovitis as claimed in claim 1, it is characterized in that: crude drug composition and the parts by weight of making described plaster are: Radix Zanthoxyli 20 parts, Radix Litseae 10 parts, Radix Anisodi Acutanguli 6 parts, Pine Nodular Branch 8 parts, Radix Gentianae Macrophyllae 4 parts, Caulis Erycibes 8 parts, Rhizoma Drynariae 8 parts, Radix Alangii side root 2 parts, Radix Schefflerae Arboricolae 12 parts, Rhizoma Corydalis Decumbentis 10 parts, Pyritum 2 parts, Semen Caesalpiniae Minacis 6 parts, Herba Polygalae Japonicae 5 parts, Radix berchemiae lineatae 3 parts, Oletum Trogopterori 5 parts, Fructus Liquidambaris 7 parts, Herba Aristolochiae Mollissimae 8 parts, Cortex araliae chinensis 6 parts, Herba Portulacae 12 parts, Aloe 10 parts, blue berry 12 parts, Radix Glycyrrhizae Preparata 5 parts, laurocapram 15 parts, squalane 9 parts, propolis 13 parts, chamomile essential oil 8 parts, dicyano Isobutyl 2-propenoate 3 parts.

5. the preparation method of the plaster of any one the treatment tenosynovitis as described in Claims 1-4, is characterized in that: comprise the following steps:

(1) Radix Litseae, Radix Anisodi Acutanguli, Pine Nodular Branch, Radix Gentianae Macrophyllae, Radix Alangii side root, Radix Schefflerae Arboricolae, Rhizoma Corydalis Decumbentis, Pyritum, Semen Caesalpiniae Minacis, Herba Polygalae Japonicae, Radix berchemiae lineatae, Oletum Trogopterori, Fructus Liquidambaris, Herba Aristolochiae Mollissimae, Cortex araliae chinensis, Radix Glycyrrhizae Preparata are crushed to 50 order Chinese medicine coarse powder;

(2) step (1) gained Chinese medicine coarse powder adds the water soaking 1 hour of gross mass multiple 4 times, slow fire boiling 2 hours, and crossing 500 order drainage screens after decocting, to obtain filtrate for subsequent use;

(3) Radix Zanthoxyli, Caulis Erycibes, Rhizoma Drynariae super micron mill are pulverized, and cross 1000 mesh sieves and obtain mixed-powder, for subsequent use;

(4) Herba Portulacae fresh goods, Aloe fresh goods, blueberry fresh fruit mixing are cleaned, add after the mixing of step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 200 order filter screen filtration, gained filtrate adds in low-temperature vacuum thickener, and cryoconcentration (less than 40 DEG C) to relative density is the thick paste of 1.30 ± 0.02 (30 DEG C);

(5) by after squalane, propolis heating and melting, continuous stirring, add laurocapram, chamomile essential oil and dicyano Isobutyl 2-propenoate, when temperature is down to 50 DEG C, add the thick paste that step (4) is obtained, mixing, then add the mixed-powder that step (3) is obtained, stirring and evenly mixing, make cream core, and be placed on sticker, obtain the plaster of described treatment tenosynovitis.