CN116459171B - Composition with allergy-relieving and repairing effects, essence and preparation method thereof - Google Patents
Composition with allergy-relieving and repairing effects, essence and preparation method thereof Download PDFInfo
- Publication number
- CN116459171B CN116459171B CN202310370100.2A CN202310370100A CN116459171B CN 116459171 B CN116459171 B CN 116459171B CN 202310370100 A CN202310370100 A CN 202310370100A CN 116459171 B CN116459171 B CN 116459171B
- Authority
- CN
- China
- Prior art keywords
- parts
- phase
- essence
- allergy
- relieving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 62
- 230000000694 effects Effects 0.000 title claims abstract description 31
- 206010020751 Hypersensitivity Diseases 0.000 title claims abstract description 18
- 208000026935 allergic disease Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 25
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 24
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 24
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 24
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 22
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 22
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 52
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 34
- 238000003756 stirring Methods 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 235000011187 glycerol Nutrition 0.000 claims description 20
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 19
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 19
- 229920001285 xanthan gum Polymers 0.000 claims description 18
- 239000000230 xanthan gum Substances 0.000 claims description 18
- 229940082509 xanthan gum Drugs 0.000 claims description 18
- 235000010493 xanthan gum Nutrition 0.000 claims description 18
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 17
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 17
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 17
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 17
- 239000004475 Arginine Substances 0.000 claims description 17
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 17
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 17
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 17
- 229920006037 cross link polymer Polymers 0.000 claims description 17
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 17
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 230000008439 repair process Effects 0.000 claims description 12
- 238000004321 preservation Methods 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 241000241602 Gossypianthus Species 0.000 claims description 6
- 240000002853 Nelumbo nucifera Species 0.000 claims description 6
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 6
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 4
- 240000006122 Chenopodium album Species 0.000 claims description 2
- 235000009344 Chenopodium album Nutrition 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 42
- 230000037307 sensitive skin Effects 0.000 abstract description 9
- 210000004207 dermis Anatomy 0.000 abstract description 5
- 230000002633 protecting effect Effects 0.000 abstract description 5
- 239000000686 essence Substances 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 12
- 239000002537 cosmetic Substances 0.000 description 7
- 206010015150 Erythema Diseases 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 201000004624 Dermatitis Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 230000005778 DNA damage Effects 0.000 description 3
- 231100000277 DNA damage Toxicity 0.000 description 3
- 102000000589 Interleukin-1 Human genes 0.000 description 3
- 108010002352 Interleukin-1 Proteins 0.000 description 3
- 206010040844 Skin exfoliation Diseases 0.000 description 3
- 230000003266 anti-allergic effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000001914 calming effect Effects 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 description 2
- 240000001592 Amaranthus caudatus Species 0.000 description 2
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- -1 glycoside compounds Chemical class 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 208000010744 skin desquamation Diseases 0.000 description 2
- 230000036559 skin health Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 102000010637 Aquaporins Human genes 0.000 description 1
- 108010063290 Aquaporins Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 102000004125 Interleukin-1alpha Human genes 0.000 description 1
- 108010082786 Interleukin-1alpha Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The application provides a composition with allergy-relieving and repairing effects, essence and a preparation method thereof, and relates to the technical field of skin care products. The composition with the allergy-relieving and repairing effects is characterized by comprising the following components in parts by weight: 0.1-2 parts of ectoine, 0.1-2 parts of glyceroglycosides, 0.5-5 parts of oat beta-glucan and 0.05-0.5 part of sodium hyaluronate. The composition with the allergy-relieving and repairing effects and the essence containing the composition have allergy-relieving, repairing and protecting effects from the dermis layer and the skin surface respectively, and can be widely applied to sensitive skin groups.
Description
Technical Field
The application relates to the technical field of skin care products, in particular to a composition with a allergy-relieving and repairing effect, essence and a preparation method thereof.
Background
The modern society continues to develop at a high speed, the urban life rhythm is accelerated, and under the influence of external environmental factors such as ultraviolet irradiation damage, stimulation sensitization sources in abused cosmetics and cosmetic raw materials, and psychological factors, the skin of people is more or less stimulated, and sensitive skin becomes extremely common. Sensitive skin is a physiological hyperreactive state of the skin to environmental or internal factors rather than a disease. The skin barrier is damaged, so that the repair of a self system is imperfect, the water loss through the epidermis is increased, the living environment of cells is influenced, the balance and stability among cells are destroyed, the resistance of the skin is finally reduced, and subjective symptoms such as itching, burning, tightness and the like are easy to appear, and objective signs such as erythema, scales, telangiectasia and the like are not accompanied.
In recent years, more and more consumers are afflicted with skin sensitivity problems, especially for people with skin sensitivity, natural safety raw materials are needed to be adopted, the skin sensitivity problems are scientifically solved through various links, and meanwhile, the product also needs to have definite efficacy. Therefore, the development of the comfortable skin care composition which is safe, stable, easy to use, obvious in effect and high in cost performance has very good development prospect.
Disclosure of Invention
The purpose of the application is to provide a composition with the effects of soothing and repairing, which has the effects of soothing and repairing and protecting the dermis layer and the skin surface respectively, and has good effects of preventing and repairing sensitive skin when being applied to cosmetics.
Another object of the present application is to provide a serum which can further enhance the comfort and repair effect of the composition.
Still another object of the present application is to provide a preparation method of the essence, which is simple and convenient.
The technical problem of the application is solved by adopting the following technical scheme.
In one aspect, embodiments of the present application provide a composition having a allergy-relieving and repair effect, comprising the following components in parts by weight: 0.1-2 parts of ectoine, 0.1-2 parts of glyceroglycosides, 0.5-5 parts of oat beta-glucan and 0.05-0.5 part of sodium hyaluronate.
On the other hand, the embodiment of the application provides essence, which comprises the composition with the allergy-relieving and repairing effects, and further comprises the following components: water, glycerol, xanthan gum, disodium EDTA, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, arginine, dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract.
In still another aspect, an embodiment of the present application further provides a method for preparing an essence, including the following steps:
s1: sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 75-85 ℃, homogenizing and preserving heat to obtain a phase A mixture;
s2: mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, maintaining the temperature, and stirring to obtain phase A/B mixture;
s3: mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
s4: adding arginine into the A/B/C phase mixture, homogenizing and preserving heat;
s5: cooling to 40-50deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring to obtain essence.
The unique molecular structure of the ectoin has strong water molecule complexing capability, can structure free water in cells, and is a very excellent natural humectant; in addition, the ectoin can repair the damage of ultraviolet rays to the skin and repair the cell DNA damage caused by the ultraviolet rays.
Sodium hyaluronate is an inherent component in the human body and has no species specificity, and the moisture level of the skin is closely related to the sodium hyaluronate content. Sodium hyaluronate not only has better moisture retention and lubricity, but also can permeate into the dermis layer of the skin to deeply nourish the skin.
The beta-glucan can quickly restore the ability of lymphocytes of injured organisms to produce cytokine (IL-1) and effectively regulate the immune function of the organisms.
The glyceroglycosides are glycoside compounds formed by connecting glucosyl and glycerol through glycosidic bonds, can penetrate into dermis layers, have long-acting moisturizing, repairing and relieving effects, have a polyhydroxy structure which can keep cell moisture, and comprehensively moisturize cells at the cell level by promoting aquaporin synthesis, and have a good moisturizing effect; the glycerol glucoside can promote the expression of type I collagen, so as to enhance skin elasticity and collagen and promote skin barrier repair; in addition, the glyceroglycosides can also obviously reduce the release amount of inflammatory factors such as IL-1 beta, IL-1 alpha and the like, obviously improve the cell healing rate and have better anti-inflammatory and relieving effects.
Compared with the prior art, the application has at least the following advantages or beneficial effects:
aiming at the first aspect, the composition can combine water molecules to form a layer of hydrated shell around cells and proteins by utilizing the extremely strong hydrophilic characteristic of the ectoin, so that the loss of skin moisture is reduced, the skin is well moisturized, and the skin and nerves which are stimulated and damaged are calm and comfortable. On the basis of ectoin, the glyceroglycosides relieve skin inflammation, and cooperate with oat beta-glucan to promote the recovery of cytokines (IL-1), and sodium hyaluronate deeply nourishes the skin to repair damaged skin. The raw material compounding can effectively improve the moisturizing effect of skin, improve the immune protection capability of skin cells, repair DNA damage caused by ultraviolet rays, increase the cell restoration capability, play a good role in repairing skin desquamation, redness, burning and other states, and accelerate the recovery of skin health. In summary, the soothing and repairing composition can relieve skin damage caused by ultraviolet rays, skin aging caused by dry environment and skin deterioration caused by surfactants to a certain extent, is safe and mild and has no irritation, and can be used as a soothing and repairing active component applied to various cosmetics.
Aiming at the second aspect, dipotassium glycyrrhizinate in the essence enhances the anti-inflammatory and antiallergic effects; the herba Saussureae Involueratae extract has antiinflammatory, tissue repairing and superoxide radical resisting effects, and can protect skin from ultraviolet; the velvet flower extract has extremely strong antioxidation effect, has the effects of relieving, calming, whitening and nourishing and protecting the skin, can increase barrier protection outside the skin, and reduces the stimulation of external ultraviolet or pollution factors to sensitive skin.
In conclusion, the composition with the allergy-relieving and repairing effects and the essence containing the composition have allergy-relieving, repairing and protecting effects from the dermis layer and the skin surface respectively, and can be widely applied to sensitive skin groups.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail with reference to specific examples.
A composition with allergy-relieving and repairing effects comprises the following components in parts by weight: 0.1-2 parts of ectoine, 0.1-2 parts of glyceroglycosides, 0.5-5 parts of oat beta-glucan and 0.05-0.5 part of sodium hyaluronate.
The composition utilizes the extremely strong hydrophilic characteristic of the ectoin, can combine water molecules to form a layer of hydration shell around cells and proteins, reduces the loss of skin moisture, plays a good role in moisturizing the skin, and further plays a role in calming and soothing the stimulated and damaged skin and nerves. On the basis of ectoin, the glyceroglycosides relieve skin inflammation, and cooperate with oat beta-glucan to promote the recovery of cytokines (IL-1), and sodium hyaluronate deeply nourishes the skin to repair damaged skin. The raw material compounding can effectively improve the moisturizing effect of skin, further improve the immune protection capability of skin cells, repair DNA damage caused by ultraviolet rays, increase the cell restoration capability, play a good role in repairing skin desquamation, redness, burning and other states, and accelerate the recovery of skin health. In summary, the soothing composition can alleviate skin damage caused by ultraviolet rays, skin aging caused by dry environment, and skin deterioration caused by surfactant to some extent. And the whole composition is mild and non-irritating, and can be used as a soothing and repairing active component in various cosmetics.
The essence comprises the composition with the allergy-relieving and repairing effects, and further comprises the following components: water, glycerol, xanthan gum, disodium EDTA, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, arginine, dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract.
Dipotassium glycyrrhizinate in the essence enhances the anti-inflammatory and antiallergic effects, and xanthan gum and glycerin regulate the consistence; the herba Saussureae Involueratae extract has antiinflammatory, tissue repairing and superoxide radical resisting effects, and can protect skin from ultraviolet; the velvet flower extract has extremely strong antioxidation effect, has the effects of relieving, calming, whitening and nourishing and protecting the skin, can increase barrier protection outside the skin, and reduces the stimulation of external ultraviolet or pollution factors to sensitive skin.
In some embodiments of the present application, the following ingredients are included per 100 parts by weight of the serum: 0.1-2 parts of ectoin, 0.1-2 parts of glyceroglycosides, 0.5-5 parts of oat beta-glucan, 0.05-0.5 part of sodium hyaluronate, 2-4 parts of glycerol, 0.01-0.1 part of xanthan gum, 0.01-0.05 part of EDTA disodium, 1-3 parts of nicotinamide, 2-4 parts of butanediol, 0.1-0.6 part of p-hydroxyacetophenone, 0.2-0.8 part of 1, 2-hexanediol, 0.1-0.3 part of acrylic acid (ester) type/C10-30 alkanol acrylate cross-linked polymer, 0.01-0.08 part of arginine, 0.01-0.5 part of dipotassium glycyrrhizinate, 1-3 parts of herba saussureae extract, 1-3 parts of chenopodium album extract and water.
In some embodiments of the present application, the above-described serum comprises the following ingredients: 1 part of ectoine, 1 part of glyceroglycoside, 3 parts of oat beta-glucan, 0.2 part of sodium hyaluronate, 3 parts of glycerin, 0.05 part of xanthan gum, 0.02 part of EDTA disodium, 2 parts of nicotinamide, 3 parts of butanediol, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.15 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, 0.05 part of arginine, 0.2 part of dipotassium glycyrrhizinate, 2 parts of snow lotus herb extract, 2 parts of snow cotton flower extract and 81.33 parts of water.
The preparation method of the essence comprises the following steps:
s1: sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 75-85 ℃, homogenizing and preserving heat to obtain a phase A mixture;
s2: mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, maintaining the temperature, and stirring to obtain phase A/B mixture;
s3: mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
s4: adding arginine into the A/B/C phase mixture, homogenizing and preserving heat;
s5: cooling to 40-50deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring to obtain essence.
In some embodiments of the present application, the homogenization time in step S1 is 5-10min, and the incubation time is 5-10min.
In some embodiments of the present application, the homogenization time in step S4 is 1-3min, and the incubation time is 5-10min.
In some embodiments of the present application, the above-described homogenizing speed is 800-1200rpm, and the stirring speed is 400-600rpm.
The features and capabilities of the present application are described in further detail below in connection with the examples.
Example 1
A composition with the efficacy of comfort and repair comprises the following raw materials: 1g of ectoine, 1g of glyceroglycoside, 3g of oat beta-glucan and 0.2g of sodium hyaluronate.
Mixing the above materials at room temperature.
The composition can be added into cosmetics for use.
Example 2
An essence is prepared by the following steps:
preparing materials: 1g of ectoine, 1g of glyceroglycoside, 3g of oat beta-glucan, 0.2g of sodium hyaluronate, 3g of glycerin, 0.05g of xanthan gum, 0.02g of EDTA disodium, 2g of nicotinamide, 3g of butanediol, 0.5g of p-hydroxyacetophenone, 0.5g of 1, 2-hexanediol, 0.15g of acrylic acid (esters) or C10-30 alkanol acrylate cross-linked polymer, 0.05g of arginine, 0.2g of dipotassium glycyrrhizinate, 2g of snow lotus herb extract, 2g of snow cotton flower extract and 81.33g of water;
sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 80 ℃ at a speed of 500rpm, homogenizing for 10min, and preserving heat for 8min to obtain a phase A mixture;
mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, and continuing to stir at 80deg.C to obtain phase A/B mixture;
mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
adding arginine into the A/B/C phase mixture, homogenizing for 1min, and maintaining the temperature for 10min;
cooling the mixture to 40deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring at 500rpm to obtain essence.
Example 3
An essence is prepared by the following steps:
preparing materials: 2g of ectoine, 0.5g of glyceroglycoside, 5g of oat beta-glucan, 0.05g of sodium hyaluronate, 2g of glycerin, 0.01g of xanthan gum, 0.05g of EDTA disodium, 1g of nicotinamide, 2g of butanediol, 0.1g of p-hydroxyacetophenone, 0.2g of 1, 2-hexanediol, 0.1g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.01g of arginine, 0.5g of dipotassium glycyrrhizinate, 2g of snow lotus herb extract, 3g of snow cotton flower extract and 81.97g of water;
sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 85 ℃ at the speed of 400rpm, homogenizing for 5min, and preserving heat for 10min to obtain a phase A mixture;
mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, and continuing to stir at 85 ℃ to obtain phase A/B mixture;
mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
adding arginine into the A/B/C phase mixture, homogenizing for 2min, and maintaining the temperature for 10min;
cooling the mixture to 50deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring at 400rpm to obtain essence.
Example 4
An essence is prepared by the following steps:
preparing materials: 0.1g of ectoine, 2g of glyceroglycoside, 0.5g of oat beta-glucan, 0.5g of sodium hyaluronate, 4g of glycerin, 0.1g of xanthan gum, 0.01g of EDTA disodium, 3g of nicotinamide, 4g of butanediol, 0.6g of p-hydroxyacetophenone, 0.8g of 1, 2-hexanediol, 0.3g of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.08g of arginine, 0.1g of dipotassium glycyrrhizinate, 1g of snow lotus herb extract, 2g of snow cotton flower extract and 81.91g of water;
sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 75 ℃ at the speed of 600rpm, homogenizing for 10min, and preserving heat for 5min to obtain a phase A mixture;
mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, and continuing to stir at 75deg.C to obtain phase A/B mixture;
mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
adding arginine into the A/B/C phase mixture, homogenizing for 3min and maintaining the temperature for 8min;
cooling the mixture to 40deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring at 400rpm to obtain essence.
Example 5
An essence is prepared by the following steps:
preparing materials: 1.5g of ectoine, 1g of glyceroglycoside, 4.5g of oat beta-glucan, 0.1g of sodium hyaluronate, 2g of glycerin, 0.05g of xanthan gum, 0.02g of EDTA disodium, 3g of nicotinamide, 3g of butanediol, 0.4g of p-hydroxyacetophenone, 0.2g of 1, 2-hexanediol, 0.1g of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.01g of arginine, 0.5g of dipotassium glycyrrhizinate, 3g of snow lotus herb extract, 2g of snow cotton flower extract and 78.62g of water;
sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 80 ℃ at a speed of 500rpm, homogenizing for 8min, and preserving heat for 10min to obtain a phase A mixture;
mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, and continuing to stir at 80deg.C to obtain phase A/B mixture;
mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
adding arginine into the A/B/C phase mixture, homogenizing for 2min, and maintaining the temperature for 8min;
cooling the mixture to 40deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring at 500rpm to obtain essence.
Experimental example
The essence prepared in examples 2-5 of the present application was tested for skin irritation and allergy according to the requirements of the new drug toxicology study guidelines, with the end result of no erythema, no edema, no irritation, and no sensitization. The essence prepared by the embodiment of the application has no stimulation to skin, and can be directly used for daily skin care of human bodies.
(II) the essences prepared in examples 2-5 were evaluated in accordance with the trans-epidermal moisture loss (TEWL) test.
40 sensitive skin volunteers, women in average age 29.5 years, were selected and randomized into 4 experimental groups of 10 persons each. Inclusion criteria: (1) Meets the sensitive skin judgment standard, namely, the face skin is easy to produce subjective feelings such as itching, burning, stinging, tightening and the like after being stimulated by the outside, with or without objective signs such as erythema, desquamation and the like, the lactic acid stinging test is more than or equal to 3 minutes, and the noninvasive skin detects that the skin has tiny degree change; (2) The subject did not use other antiallergic oral and topical medications during the observation period; (3) use of the test article during the study as directed by the physician.
The using method comprises the following steps: the test group was applied to the face after cleansing, and the skin moisture loss (TEWL) values were measured before, on day 14 and on day 28, respectively, twice daily for 28 consecutive days, with the results shown in table 1.
TABLE 1
As can be seen from table 1, the TEWL of each group of users is significantly reduced (P < 0.01) compared to before the experiment, indicating that the essence prepared in examples 2-5 of the present application has an effect of significantly repairing the stratum corneum barrier.
(III) the relieving ability of the essence prepared in the application according to the standard T/SHRH 034-2020 cosmetic relieving efficacy test-in-vitro TNF-alpha inflammatory factor content determination lipopolysaccharide induced macrophage RAW264.7 test method).
The essence prepared in the same amount of examples 2-5 is dissolved in dimethyl sulfoxide, shaken and fully mixed to prepare an example experiment product with the dosage of 2000 mug/mL, a negative control group (the same amount of cell culture medium containing LPS) is arranged, a positive control group (100 mug/mL dexamethasone is added into the cell culture medium containing the same amount of LPS), normal human dermal cells are respectively placed in the six groups of culture solutions, and the culture is carried out for 24 hours under the conditions of saturated humidity, constant temperature of 37 ℃ and 5v% carbon dioxide by using a high sugar culture medium. After the completion of the culture, the TNF- α content was measured, and the inhibition ratio of TNF- α was calculated as compared with the negative control group, and the inhibition ratio is shown in Table 2.
TABLE 2
As can be seen from Table 2, compared with the negative control group, the essence prepared in examples 2-5 of the present application can significantly inhibit the expression of inflammatory factor TNF-alpha in human dermal cells, indicating that it has significant inhibitory and soothing effects on skin inflammation.
The embodiments described above are some, but not all, of the embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
Claims (6)
1. The essence with the allergy-relieving and repairing effects is characterized by comprising the following components in parts by weight: 0.1-2 parts of ectoin, 0.1-2 parts of glyceroglycosides, 0.5-5 parts of oat beta-glucan, 0.05-0.5 part of sodium hyaluronate, 2-4 parts of glycerol, 0.01-0.1 part of xanthan gum, 0.01-0.05 part of EDTA disodium, 1-3 parts of nicotinamide, 2-4 parts of butanediol, 0.1-0.6 part of p-hydroxyacetophenone, 0.2-0.8 part of 1, 2-hexanediol, 0.1-0.3 part of acrylic acid (ester) type/C10-30 alkanol acrylate cross-linked polymer, 0.01-0.08 part of arginine, 0.01-0.5 part of dipotassium glycyrrhizinate, 1-3 parts of herba saussureae extract, 1-3 parts of chenopodium album extract and water.
2. The essence with allergy-relieving and repairing effects according to claim 1, wherein the essence comprises the following components in parts by weight per 100 parts by weight: 1 part of ectoine, 1 part of glyceroglycoside, 3 parts of oat beta-glucan, 0.2 part of sodium hyaluronate, 3 parts of glycerin, 0.05 part of xanthan gum, 0.02 part of EDTA disodium, 2 parts of nicotinamide, 3 parts of butanediol, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.15 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, 0.05 part of arginine, 0.2 part of dipotassium glycyrrhizinate, 2 parts of snow lotus herb extract, 2 parts of snow cotton flower extract and 81.33 parts of water.
3. A process for preparing a serum with a comfort and repair effect according to any one of claims 1 to 2, characterized by comprising the following steps:
s1: sequentially adding water, EDTA disodium, nicotinamide, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a container, stirring and heating to 75-85 ℃, homogenizing and preserving heat to obtain a phase A mixture;
s2: mixing glycerol and xanthan gum at 25deg.C to obtain phase B; adding phase B into phase A, maintaining the temperature, and stirring to obtain phase A/B mixture;
s3: mixing the ectoin, the glyceroglycosides, the oat beta-glucan and the sodium hyaluronate to obtain a C phase, adding the C phase into the A/B phase mixture, and carrying out heat preservation and stirring uniformly to obtain the A/B/C phase mixture;
s4: adding arginine into the A/B/C phase mixture, homogenizing and preserving heat;
s5: cooling to 40-50deg.C, adding dipotassium glycyrrhizinate, herba Saussureae Involueratae extract and herba Centipedae extract, and stirring to obtain essence.
4. The method for preparing the essence with the allergy-relieving and repairing effects according to claim 3, wherein the homogenizing time in the step S1 is 5-10min, and the heat preservation time is 5-10min.
5. The method for preparing the essence with the allergy-relieving and repairing effects according to claim 3, wherein the homogenizing time in the step S4 is 1-3min, and the heat preservation time is 5-10min.
6. A process for the preparation of a concentrate with a allergy-free conditioning effect according to claim 3, characterized in that said homogenizing speed is 800-1200rpm and said stirring speed is 400-600rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310370100.2A CN116459171B (en) | 2023-04-10 | 2023-04-10 | Composition with allergy-relieving and repairing effects, essence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310370100.2A CN116459171B (en) | 2023-04-10 | 2023-04-10 | Composition with allergy-relieving and repairing effects, essence and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116459171A CN116459171A (en) | 2023-07-21 |
| CN116459171B true CN116459171B (en) | 2024-04-02 |
Family
ID=87174539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310370100.2A Active CN116459171B (en) | 2023-04-10 | 2023-04-10 | Composition with allergy-relieving and repairing effects, essence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116459171B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812311A (en) * | 2019-11-19 | 2020-02-21 | 上海若梵生物科技有限公司 | Novel acne-removing anti-allergy repair essence and preparation method thereof |
| KR20200073970A (en) * | 2018-12-14 | 2020-06-24 | 안디바 주식회사 | Soothing cream and manufacturing method for the same |
| CN113876653A (en) * | 2021-10-12 | 2022-01-04 | 北京妍之素生物科技有限公司 | Soothing essence and preparation method thereof |
| CN114948834A (en) * | 2022-07-15 | 2022-08-30 | 广州市丽泽化妆品有限公司 | Soothing and moisturizing essence and preparation method thereof |
| CN115804745A (en) * | 2022-12-27 | 2023-03-17 | 广州天然国度生物科技有限公司 | Skin care and soothing repair composition and application thereof |
-
2023
- 2023-04-10 CN CN202310370100.2A patent/CN116459171B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200073970A (en) * | 2018-12-14 | 2020-06-24 | 안디바 주식회사 | Soothing cream and manufacturing method for the same |
| CN110812311A (en) * | 2019-11-19 | 2020-02-21 | 上海若梵生物科技有限公司 | Novel acne-removing anti-allergy repair essence and preparation method thereof |
| CN113876653A (en) * | 2021-10-12 | 2022-01-04 | 北京妍之素生物科技有限公司 | Soothing essence and preparation method thereof |
| CN114948834A (en) * | 2022-07-15 | 2022-08-30 | 广州市丽泽化妆品有限公司 | Soothing and moisturizing essence and preparation method thereof |
| CN115804745A (en) * | 2022-12-27 | 2023-03-17 | 广州天然国度生物科技有限公司 | Skin care and soothing repair composition and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116459171A (en) | 2023-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112315882B (en) | Soothing, repairing and moisturizing cream and preparation method thereof | |
| CN109908015B (en) | Anti-allergy repairing and moisturizing composition and preparation method and application thereof | |
| CN115137665B (en) | Composition with long-acting moisturizing and soothing effects and application thereof | |
| CN113133953A (en) | Composition for quickly relieving, moisturizing, strengthening and sensitive skin and preparation method and application thereof | |
| WO2021136275A1 (en) | Multi-stage fat-protecting skincare composition for protecting skin barrier of infants | |
| CN111973508A (en) | Anti-aging composition capable of relieving and moisturizing | |
| CN111840176A (en) | A skin caring composition with effects of resisting glycosylation, whitening skin, removing speckle and removing wrinkle, and its application | |
| CN110638727A (en) | Infant hip-protecting composition and preparation method and application thereof | |
| CN114712275A (en) | Anti-wrinkle repair composition and preparation method thereof, and cosmetic and preparation method thereof | |
| CN114796024B (en) | Bionic sebum composition for skin barrier repair, and preparation method and application thereof | |
| CN113456568A (en) | Composition for soothing, repairing and moisturizing skin and preparation method and application thereof | |
| CN114748367A (en) | Moisturizing repair essence and preparation method thereof | |
| CN108852976B (en) | Crystal moistening nourishing lotion | |
| CN108721154B (en) | Skin care product for skin moisturizing and barrier repair and preparation method thereof | |
| KR100904200B1 (en) | Cosmetic composition for moisturizing the skin containing the extract of Prunella Vulgaris and Aloe Barbadensis leaf | |
| CN112656731A (en) | Composition with red-repairing effect and preparation method and application thereof | |
| KR20100087522A (en) | Body detergent composition for moisturizing or soothing the skin containing aloe barbadensis miller extract and althaea officinalis root extract | |
| CN116459171B (en) | Composition with allergy-relieving and repairing effects, essence and preparation method thereof | |
| CN108771652B (en) | Plant skin care composition and skin cream with same | |
| CN108451790B (en) | Moisturizing essence containing hydrophilic keratin and preparation method thereof | |
| CN115919686A (en) | Skin soothing lotion for enhancing skin barrier and preparation method thereof | |
| JP3213189B2 (en) | Hyaluronic acid production promoter | |
| KR101077693B1 (en) | Cosmetic composition containing xylitol and β-1,3-glucane for moisturizing effect on the skin | |
| CN109431881B (en) | Tibetan sheep oil for preventing skin from being cracked due to dryness | |
| CN113384483A (en) | Composition for improving skin elasticity and delaying aging and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |