CN114652631B

CN114652631B - Composition and cosmetic for removing black eye and preparation method thereof

Info

Publication number: CN114652631B
Application number: CN202210426269.0A
Authority: CN
Inventors: 林吉珊; 韩志东; 张娇
Original assignee: Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
Current assignee: Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
Priority date: 2022-04-22
Filing date: 2022-04-22
Publication date: 2023-10-13
Anticipated expiration: 2042-04-22
Also published as: CN114652631A

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a composition for removing black eye, a cosmetic and a preparation method thereof. The black eye removing composition comprises the following components in parts by weight: 0.05-0.7 part of glucosyl hesperidin, 0.005-0.1 part of carboxymethyl chitosan, 0.001-0.1 part of glabridin, 0.0001-0.05 part of palmitoyl tripeptide-5 and 0.0001-0.06 part of passion fruit extract. The composition for removing the black eye provided by the invention has the advantages of interaction and omnibearing coordination, plays an optimal eye skin repairing role, reduces the area of severe pigmentation, improves the strength of capillary vessels and lymphatic vessels, reduces the penetration of the capillary vessels and blood stasis, and finally achieves the effect of reducing the black eye.

Description

Composition and cosmetic for removing black eye and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a composition for removing black eye, a cosmetic and a preparation method thereof.

Background

The black eye ring, commonly called panda eye, is ring-shaped in the orbit inferior area at both sides, the phenomenon of green or black tea is a common eye problem. The eye skin has the following characteristics: (1) the thickness of the skin of the eyes is 0.6-4.0mm, which is 1/3-1/5 of the thickness of the skin of the face; (2) skin is continuously stretched when blinking every day; (3) only sebaceous glands and abnormal sweat glands are arranged around the eyes, so that the water fat film has small protective effect on the skin of the eyes; (4) the skin of the eyes has low fat content and lacks elastic fiber and collagen structure, so the skin of the eyes is easy to lose elasticity and even has the phenomenon of early aging; (5) the nerve fiber and capillary vessel around the eyes are high in distribution density, and the poor blood circulation is easy to cause the darkness and fatigue of the eyes. Therefore, the phenomena of dark eye circles, eye bags, fish tail lines, fat particles and the like are easy to cause due to irregular life work and rest, improper eyes and the like.

Studies have shown that the formation of dark circles is mainly associated with pigmentation and vascular changes. The black eye can be classified into four types of vascular type, pigment type, relaxation type, and compound type according to the black eye formation mechanism. The vascular black eye is always black and blue, the blood flow velocity in the micro blood vessels is slow due to factors such as insufficient sleep, eye fatigue and the like, the blood quantity is increased, the oxygen consumption is increased, the anoxic heme is greatly increased, the phenomena of skin congestion and edema around eyes are caused, and the black eye appears after light reflection; the pigment-type black eye is tea black, and is mainly formed by long-term sun exposure, excessive dryness of skin and blood retention, so that pigment is deposited around eyes; the loose black eye is a dent generated by aging and thinning of eye skin and loss of collagen, and a cyan shade is formed at the bottom of an eye socket; the fourth compound black eye is a mixed black eye, and the first three types of black eye exist simultaneously in 2-3 cases.

Currently, more and more people are deeply plagued by dark circles. Therefore, in recent years, the popularization of cosmetic products for black eye repair and eye care has been increasing, and the demand for eye repair care has also been greatly increased. However, although there are a few products for removing black eyes in the market at present, the mechanisms and functions of the products are single, and the comprehensive causes of the black eyes are not considered, so that a good effect of removing the black eyes cannot be achieved, and therefore, people have a strong demand for developing novel products for removing the black eyes.

For example, patent CN112656745a discloses an eye anti-aging nutrient solution, and a preparation method and application thereof. The nutritional liquid is prepared by improving skin texture by using seaweed extract, wheat extract and oat extract rich in anions and skin hematopoiesis; and whitening is performed by cherry extract, grape seed extract, guava extract and yeast extract. For another example, patent CN113181103a discloses an eye essence for removing dark circles and wrinkles, which is prepared from the following raw materials, by weight, 3-5 parts of deionized water, 2-4 parts of butylene glycol, 0.5 part of p-hydroxyacetophenone, 0.2 part of sodium polyacrylate, 0.05 part of allantoin, 2-5 parts of deionized water, 2-5 parts of lactobacillus strain extract, 2-5 parts of tea extract, 2-5 parts of pericarpium Granati extract, 2-5 parts of small fruit coffee seed extract, 2-5 parts of euglena parvifolia polysaccharide, 2-5 parts of hydrolyzed collagen, 0.5-1 part of placenta protein, 0.5 part of 1, 2-hexanediol and 0.05-0.1 part of acetyl hexapeptide.

However, the mechanism and the function of the technical proposal are single, and the comprehensive cause of the black eye is not considered, so that the technical proposal cannot have good black eye removing effect. Therefore, development of novel dark-eyed eye-removing products has been strongly demanded.

Disclosure of Invention

The invention provides a composition and a cosmetic for removing black eye and a preparation method thereof, which are used for overcoming the defects in the prior art. The composition for removing the black eye provided by the invention has the advantages of interaction and omnibearing coordination, plays an optimal role in repairing the eye skin, reduces the severe pigmentation area, improves the strength of capillary vessels and lymphatic vessels, reduces the penetration of the capillary vessels and blood stasis, and finally achieves the effect of reducing the black eye.

The technical scheme of the invention is as follows:

the composition for removing black eye comprises the following components in parts by weight: 0.05 to 0.7 part of glucosyl hesperidin, 0.005 to 0.1 part of carboxymethyl chitosan, 0.001 to 0.1 part of glabridin, 0.0001 to 0.05 part of palmitoyl tripeptide-5 and 0.0001 to 0.06 part of passion fruit extract. The composition is a product with strong effect of eliminating black eye from the aspects of reducing pigmentation, inhibiting inflammation, improving vasodilation, promoting lymphatic circulation, enhancing collagen tightening eye skin and the like based on the formation mechanism of black eye.

Further, the black eye removing composition comprises the following components in parts by weight: 0.3 part of glucosyl hesperidin, 0.05 part of carboxymethyl chitosan, 0.07 part of glabridin, 0.015 part of palmitoyl tripeptide-5 and 0.04 part of passion fruit extract. The passion fruit extract is passion fruit (PASSIFLORA EDULIS) fruit extract.

In addition, the invention also provides a black eye removing cosmetic which comprises the black eye removing composition and an auxiliary agent.

Further, the auxiliary agents in the black eye removing cosmetic are as follows: the composition for removing dark circles, EDTA disodium, propylene glycol, 1, 2-hexanediol, p-hydroxyacetophenone and water.

The invention also provides a preparation method of the black eye removing cosmetic, which comprises the following steps:

(1) The components are accurately weighed according to the proportion:

component 1: disodium EDTA, propylene glycol, 1, 2-hexanediol, p-hydroxyacetophenone;

component 2: glucosyl hesperidin, carboxymethyl chitosan, glabridin, palmitoyl tripeptide-5, passion fruit extract;

(2) Adding the components of the component 1 and water into a pot, heating, homogenizing, stirring, defoaming, and then continuously stirring and cooling;

(3) Maintaining the temperature of the material in the pot; and (3) dissolving and dispersing the component 2 uniformly, adding the components into a pot, homogenizing, stirring, cooling and discharging. The raw materials in the component 2 are powder, the raw materials are liquid, and the powder is dissolved when the raw materials are mixed together.

Further, the heating temperature in the step (2) is 80-85 ℃.

Further, in the step (2), the homogenizing speed is 2000-3000rpm, and the homogenizing time is 2-5min; in the step (3), the homogenizing speed is 2000-3000rpm, and the homogenizing time is 2-4min.

Further, the stirring speed before the defoaming operation in the step (2) is 10-25rpm for 3-5min.

Further, in the step (2), vacuum defoaming is adopted for defoaming.

Further, in the step (2), stirring and cooling are continued subsequently as follows: stirring at 10-25rpm, and cooling to 45deg.C; in the step (3), the stirring speed is 10-25rpm, and the temperature is reduced to 30 ℃.

The invention is based on the formation mechanism of black eye, and comprehensively considers the aspects of reducing pigmentation, inhibiting inflammation, improving vasodilation, promoting lymphatic circulation, enhancing collagen tightening eye skin and the like, and finally develops and obtains the composition with stronger black eye removal effect.

Through the collocation of multiple efficacy mechanisms, the invention adopts carboxymethyl chitosan to effectively inhibit the activity of inflammatory factors; the glabra can effectively reduce melanin deposition around eyes, resist external invasion and free radicals, and reduce skin moisture loss, so that dark circles are effectively relieved and removed, skin aging is delayed, and skin luster is improved; in addition, due to the increase of the age, the expression of the tissue growth factor beta is reduced, so that the elasticity of the skin is reduced, and thus, the palmitoyl tripeptide-5 promotes the synthesis of collagen I and acts on the synthesis of hyaluronic acid of aged fibroblasts by activating the tissue growth factor beta; promote collagen synthesis and protect it from degradation; in addition, glucosyl hesperidin can reduce the amount of accumulated liquid in the region to eliminate edema and improve skin metabolism by reducing the permeability of blood vessels in the region, and by helping the regeneration of lymphatic vessels. It should be noted that the combination and compounding of glucosyl hesperidin, glabridin, palmitoyl tripeptide-5 and passion fruit extract of the invention achieve the effect which is obviously superior to that of single or simple combination, and achieve the effects of reducing eye edema, resisting inflammation, enhancing skin elasticity, calming and strongly moisturizing skin and fading dark circles.

Compared with the prior art, the composition and the cosmetic for removing dark circles provided by the invention have the following advantages:

the black eye removing composition provided by the invention is comprehensively considered in aspects of reducing pigmentation, inhibiting inflammation, improving vasodilation, promoting lymphatic circulation, enhancing collagen and compacting eye skin, and the like, so that the effects of reducing eye edema, resisting inflammation, enhancing skin elasticity, calming and strongly moisturizing skin and fading black eyes are realized. Wherein, glucosyl hesperidin, carboxymethyl chitosan, glabridin, palmitoyl tripeptide-5 and passion fruit extract interact with each other, and the coordination plays a role in effectively repairing eye skin, improving the strength of capillary vessels and lymphatic vessels while reducing the severe pigmentation area of pigment, reducing the penetration and blood stasis of the capillary vessels, and finally realizing the change of skin pigmentation, so that the black eye circles are effectively eliminated.

Detailed Description

The invention is further illustrated by the following description of specific embodiments, which are not intended to be limiting, and various modifications or improvements can be made by those skilled in the art in light of the basic idea of the invention, but are within the scope of the invention as long as they do not depart from the basic idea of the invention.

Wherein the glucosyl hesperidin used in the invention is purchased from Hayashibara co., ltd; carboxymethyl chitosan was purchased from Shanghai Chunlu biochemistry Co., ltd; glycyrrhiza glabra is ordered from Shanghai Orly industries, inc.; the passion fruit (PASSIFLORA EDULIS) fruit extract is purchased from ICHIMARU PHARCOS CO., LTD; the other reagents are all common reagents and can be purchased by conventional reagent production and sale companies.

Example 1

A preparation method of a black eye removing cosmetic comprises the following steps:

(1) The components are accurately weighed according to the proportion:

(2) Adding the components of the component 1 and water into a pot, and heating to 80 ℃; homogenizing at a homogenizing speed of 2000rpm for 2min; stirring at a stirring speed of 10rpm for 3min; defoaming in vacuum; stirring at the stirring speed of 10rpm, and then continuously stirring and cooling to 45 ℃;

(3) Maintaining the temperature of the material in the pot, dissolving and dispersing the component 2 uniformly, adding the component into the pot, homogenizing at 2000rpm for 2min; stirring at a stirring speed of 10rpm, cooling to 30deg.C, and discharging.

The dosage ratio of the component 1 to the component 2 is 1:6.38; wherein, each component in the component 1 comprises the following components in parts by weight: 0.03 part of EDTA disodium, 2.0 parts of propylene glycol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone. The consumption of the component 1, the component 2 and the water in the black eye removing cosmetic is 100 parts by weight. Wherein the components of component 2 are shown in Table 1.

Example 2

(1) The components are accurately weighed according to the proportion:

(2) Adding the components of the component 1 and water into a pot, and heating to 85 ℃; homogenizing at 3000rpm for 5min; stirring at 25rpm for 5min; defoaming in vacuum; stirring at a stirring speed of 25rpm, and then continuously stirring and cooling to 45 ℃;

(3) Maintaining the temperature of the material in the pot; dissolving and dispersing the component 2 uniformly, adding the components into a pot, homogenizing at 3000rpm for 4min; stirring at 25rpm, cooling to 30deg.C, and discharging.

Example 3

(1) The components are accurately weighed according to the proportion:

(2) Adding the components of the component 1 and water into a pot, and heating to 80 ℃; homogenizing at 2500rpm for 3min; stirring at 15rpm for 4min; defoaming in vacuum; stirring at 15rpm, and then continuously stirring and cooling to 45 ℃;

(3) Maintaining the temperature of the material in the pot; and (3) uniformly dissolving and dispersing the components in the component 2, adding the components into a pot, homogenizing and homogenizing at 2500rpm for 2min, stirring at 20rpm, cooling and stirring at 10rpm, cooling to 30 ℃, and discharging.

Example 4

The preparation method of example 4 is similar to that of example 3, wherein the ratio of the amount of the component 1 to the amount of the component 2 is 1:6.38; wherein, each component in the component 1 comprises the following components in parts by weight: 0.03 part of EDTA disodium, 2.0 parts of propylene glycol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone. The consumption of the component 1, the component 2 and the water in the black eye removing cosmetic is 100 parts by weight. Wherein the components of component 2 are shown in Table 1.

Comparative examples 1 to 5

Comparative examples 1 to 5 provide a black eye removing cosmetic, which is prepared in the same manner as in example 3, except that the component 2 is different in the component, and the components of component 2 in comparative examples 1 to 5 are shown in Table 1.

Table 1 formulation table

Note that: the amount of the components in the table is "parts by weight"; the passion fruit extract is passion fruit (PASSIFLORA EDULIS) fruit extract.

Test example: efficacy evaluation

1. Instrument and sample:

instrument: skin elasticity tester MPA580; skin melanin and heme test probe MX18; skin color test probe CL400.

Sample: the black eye removing cosmetic samples obtained in examples 1 to 4 and comparative examples 1 to 5 were 9 in total.

2. Selection of the subjects:

qualified volunteers were enrolled and signed with informed consent to finally complete 90 persons, 10 volunteers were tried on each sample.

Inclusion criteria: healthy female volunteers, chinese, 35-45 years old, with daily habits of using skin care products; the faces of volunteers all have fine lines/wrinkles around eyes, and are insensitive to common cosmetics; subject compliance is high.

Exclusion criteria: antihistamines used in the last week or immunosuppressants used in the last month; any anti-inflammatory drug was administered to the subject in the last two months; insulin dependent diabetes mellitus patients; a patient suffering from a respiratory disease undergoing treatment; people with allergic constitution, allergic dermatitis, etc., and people with skin history; a person who is receiving dermatological treatment or takes light acids, whitening drugs and anti-aging drugs within one month; the test area has skin characterizers with large areas of birthmarks, scratches, white spots, moles, keloids, and the like affecting the test.

3. Testing environmental conditions: the temperature of the test environment is 20-22 ℃, the humidity is 40-60%, and real-time dynamic monitoring is carried out.

4. The using method of the product comprises the following steps: samples obtained in examples and comparative examples were taken by 9 groups of people, respectively. The amount and frequency of use of the test samples were 0.2 g/time, 2 times/day (1 time each in the morning and evening), and the area of use was the periocular skin (under the eyes and canthus lines). During the test, the subjects avoid excessive uv exposure.

5. The testing process comprises the following steps:

(1) Skin color test

After 20min of sitting in a constant temperature and humidity room, the L, a, b and MI values of the skin at the test site were measured with a skin color test probe, a skin melanin and heme test probe, respectively, three times per test area, and ITA values were recorded and calculated (ITA value increase indicates skin lightening).

(2) Skin elasticity test

Opening the Cutometer Q software, clicking the tool bar Measurement or directly clicking the upper right corner Measurement button, taking down the probe cover after the start of the pump is finished, clicking OK, vertically and lightly contacting the probe with the skin subjected to cleaning or sample smearing treatment within the reciprocal time of 5s, preferably retracting the springs at the top end of the probe, starting the test, removing the probe until the test cycle time is finished, and covering the probe cover.

(3) Skin moisture test

A. Skin moisture content test procedure

Opening MPA5 software, clicking a Corneometer10030770 button at the upper right corner, taking down a probe cover, vertically lightly pressing the probe to the skin subjected to cleaning or sample smearing treatment and the like, at the moment, sensing that a spring is arranged in the probe to stretch, displaying a test result and an average value in a window after 1s, randomly selecting at least 3 points at the tested skin part to test and average the test result, and covering the probe cover.

(4) Skin moisture loss test procedure

Opening MPA5 software, clicking a Tewameter10041249 button at the upper right corner, taking down a probe cover, vertically and lightly pressing the skin subjected to cleaning or sample smearing treatment at the shorter end of the cylindrical hollow cavity of the probe, lightly pressing a handle white button, displaying a test value every 1s on a window at the moment, starting to display an average value when the 5 th time is tested, requesting to take the average value for not less than 6 times, lightly pressing the handle white button, ending the test, and covering a probe cap.

And (3) calculating and analyzing results:

the data arrangement mode is as follows: the data output are the average of 10 persons per group.

6. Test results:

ITA degree value variation:

TABLE 2ITA degree value variation

Skin elasticity test:

the elasticity R2 value represents the ratio of the rebound quantity of the skin without negative pressure to the maximum stretching quantity with negative pressure, and the closer the ratio is to 1, the better the skin elasticity is.

Table 3 skin elasticity test

	Before use	After 4 weeks of use	Improvement rate/%
				Example 1	0.654	0.756	15.59
Example 2	0.65	0.754	16
				Example 3	0.655	0.795	21.37
Example 4	0.64	0.75	17.18
				Comparative example 1	0.642	0.715	11.37
Comparative example 2	0.652	0.711	9.05
				Comparative example 3	0.655	0.732	11.75
Comparative example 4	0.645	0.732	13.48
				Comparative example 5	0.655	0.733	11.91

Skin moisture test results:

table 4 skin moisture test

Percutaneous moisture loss test data:

table 5 percutaneous moisture loss test

	Before use	After 4 weeks of use	Improvement rate/%
				Example 1	12.12	9.93	18.07
Example 2	11.81	8.85	25.06
				Example 3	12	8.64	28
Example 4	12.51	9.86	21.18
				Comparative example 1	12.33	10.85	12
Comparative example 2	11.93	10.73	10.06
				Comparative example 3	11.77	10	15.04
Comparative example 4	12.12	10.12	16.5
				Comparative example 5	12	10.2	15

According to the data of the groups, the skin brightness near the eyes is effectively improved after the test sample of the invention is used by a tester for four weeks, namely, dark circles are desalted; at the same time, the elasticity data and the skin moisture data also indicate that the skin elasticity is extracted and repaired. The results show that the effects of glucosyl hesperidin, carboxymethyl chitosan, glabridin, palmitoyl tripeptide-5 and passion fruit extract are combined in the essence, so that the full-scale interaction can be realized, the optimal eye skin repairing effect can be coordinated, the skin pigmentation can be changed, the dark eye circles can be eliminated, the area of serious pigmentation can be reduced, the strength of blood capillaries and lymphatic vessels can be improved, and the penetration of the blood capillaries and blood stasis can be reduced.

Wherein the composition described in example 3 is a preferred group, the proportions of the components of component 2 are: 0.3% of glucosyl hesperidin, 0.05% of carboxymethyl chitosan, 0.07% of glabridin, 0.015% of palmitoyl tripeptide-5 and 0.04% of passion fruit extract.

The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.

Claims

1. The composition for removing the black eye is characterized by comprising the following components in parts by weight: 0.05 to 0.7 part of glucosyl hesperidin, 0.005 to 0.1 part of carboxymethyl chitosan, 0.001 to 0.1 part of glabridin, 0.0001 to 0.05 part of palmitoyl tripeptide-5 and 0.0001 to 0.06 part of passion fruit extract.

2. The black eye removing composition according to claim 1, which comprises the following components in parts by weight: 0.3 part of glucosyl hesperidin, 0.05 part of carboxymethyl chitosan, 0.07 part of glabridin, 0.015 part of palmitoyl tripeptide-5 and 0.04 part of passion fruit extract.

3. A cosmetic for removing black eye, comprising the composition for removing black eye according to claim 1 or 2 and an auxiliary agent.

4. The dark circle removing cosmetic of claim 3, wherein the auxiliary agents are disodium EDTA, propylene glycol, 1, 2-hexanediol, p-hydroxyacetophenone, and water.

5. A method for preparing the black eye removing cosmetic according to claim 4, comprising the steps of:

(1) The components are accurately weighed according to the proportion:

(3) Maintaining the temperature of the material in the pot; and (3) dissolving and dispersing the component 2 uniformly, adding the components into a pot, homogenizing, stirring, cooling and discharging.

6. The process according to claim 5, wherein the heating temperature in the step (2) is 80 to 85 ℃.

7. The method according to claim 5, wherein the homogenization speed in step (2) is 2000 to 3000rpm for 2 to 5 minutes; in the step (3), the homogenizing speed is 2000-3000rpm, and the homogenizing time is 2-4min.

8. The process according to claim 5, wherein the stirring speed before the defoaming operation in the step (2) is 10 to 25rpm for 3 to 5 minutes.

9. The method of claim 5, wherein the defoaming in step (2) is performed by vacuum defoaming.

10. The method according to claim 5, wherein the step (2) is followed by stirring and cooling to: stirring at 10-25rpm, and cooling to 45deg.C; in the step (3), the stirring speed is 10-25rpm, and the temperature is reduced to 30 ℃.