CN115501128B

CN115501128B - Composition for regulating skin, whitening and brightening skin and essence emulsion

Info

Publication number: CN115501128B
Application number: CN202211187356.1A
Authority: CN
Inventors: 畅通; 甄文超; 传雅萍; 王佳; 杨颖洁
Original assignee: Shaanxi Changxiang Pharmaceutical Co ltd
Current assignee: Shaanxi Changxiang Pharmaceutical Co ltd
Priority date: 2022-09-26
Filing date: 2022-09-26
Publication date: 2023-08-15
Anticipated expiration: 2042-09-26
Also published as: CN115501128A

Abstract

The invention discloses a composition for skin conditioning, whitening and brightening and essence emulsion, which comprises the following components: a whitening composition, a first whitening composition, and a second whitening composition; wherein the whitening composition comprises a polyhydric alcohol and a salicylic acid derivative; the first whitening composition comprises an amino acid derivative and water, wherein the amino acid derivative comprises at least one of 1-methyl hydantoin-2-imide, octanoylglycine and octanoylsalicylic acid; the second whitening composition includes niacinamide, arginine ferulate, and potassium methoxysalicylate. The invention aims to solve the problems that most raw materials in the existing whitening products are high in component consumption and strong in irritation, and a large amount of relieving components are required to be added in the formula to neutralize the irritation of the whitening components.

Description

Composition for regulating skin, whitening and brightening skin and essence emulsion

Technical Field

The invention relates to the technical field of whitening, in particular to a composition for skin conditioning, whitening and brightening and an essence emulsion.

Background

Along with the increasing importance of cosmetic safety in the cosmetic industry, the whitening type is classified as special cosmetics, but the whitening type skin care requirement is one of the biggest types of the enthusiasm of Asian women, and the market demand is increased and not reduced, so that the safety and the whitening become an urgent port for expansion.

It has been found that melanin precipitation is caused by environmental changes, such as endocrine dyscrasia, metabolic disorder, disease injury, ultraviolet radiation, skin inflammation, in vivo oxidation and antioxidant balance disorder, etc. The shade of skin color is still largely dependent on the melanin content and distribution. Melanin is produced by melanocytes. Melanocytes are one of the important constituent cells of the skin, present as dendrites, through which melanin formed in the cells is transported to the stratum corneum. It forms an epidermis unit with keratinocyte in a certain proportion, exists in basal layer of epidermis, and the melanocyte determines skin color depth by synthesizing melanin, and can absorb ultraviolet ray at the same time, so that organism is prevented from being damaged by ultraviolet ray. The melanin formation process is specifically as follows: when the skin is irradiated with ultraviolet rays, keratinocytes are stimulated to produce inflammation, secretion of inflammatory factors, histamine, and the like, while DNA is damaged and free radicals are produced. Melanocytes are stimulated to differentiate by inflammatory factors, free radicals, and the like. The activity of the internal tyrosinase is increased, tyrosine is converted into dopa under the catalysis of tyrosinase, further the tyrosine is converted into dopa quinone, the dopa quinone is subjected to free radical reaction and finally converted into black corpuscles, and the black corpuscles are transferred to keratinocytes through dendrites, so that melanin deposition is caused.

By market analysis, the few types of safe and non-irritating whitening raw materials are not obtained, and the known mechanisms of the whitening and freckle removing raw materials are as follows: 1. inhibiting melanin gene expression such as whitening peptide; 2. complexing copper ions such as phytic acid, kojic acid derivatives and the like; 3. inhibiting transfer of melanosomes to the stratum corneum, such as nicotinamide and the like; 4. inhibiting melanin generation such as lactic acid, sodium lactate, etc.; 5. accelerating tyrosinase degradation such as linoleic acid and the like; 6. reducing and competing tyrosinase activities such as phenethyl resorcinol, glabridin, and the like; 7. reduced melanin such as vitamin C and its derivatives, etc. In the manner described above. Most of raw materials are required to have high component consumption and strong irritation, and a large amount of relieving components are required to be added into the formula to neutralize the irritation of the whitening components, so that the effects of the whitening components cannot be visually represented.

Disclosure of Invention

The invention mainly aims to provide a composition and essence emulsion for skin conditioning, whitening and brightening, and aims to solve the problems that most raw materials in the existing whitening products are required to be high in component consumption and strong in irritation, and a large amount of relieving components are required to be added in a formula to neutralize the irritation of the whitening components.

In order to achieve the aim, the invention provides a composition for skin conditioning, whitening and brightening, which comprises the following components: a whitening composition, a first whitening composition, and a second whitening composition;

wherein the whitening composition comprises a polyhydric alcohol and a salicylic acid derivative;

the first whitening composition comprises an amino acid derivative and water, wherein the amino acid derivative comprises at least one of 1-methyl hydantoin-2-imide, octanoylglycine and octanoylsalicylic acid;

the second whitening composition includes niacinamide, arginine ferulate, and potassium methoxysalicylate.

Optionally, the salicylic acid derivative comprises ethylene glycol salicylate;

the polyol includes any one of 1, 2-pentanediol, ethoxydiglycol, 1, 3-butanediol, and 1, 3-propanediol.

Optionally, the polyol is 1, 2-pentanediol;

in the whitening composition, the concentration of the 1, 2-pentanediol is 1-25 g/mL, and the concentration of the ethylene glycol salicylate is 1-4.5 g/mL.

Optionally, in the whitening composition, the 1, 2-pentanediol is 1 to 30 parts and the ethylene glycol salicylate is 1 to 5 parts.

Alternatively, the amino acid derivative is 1-methylhydantoin-2-imide and the water comprises ultrapure water;

in the first whitening composition, the 1-methylhydantoin-2-imide is 0.1 to 10 parts, and the ultrapure water is 5 to 50 parts.

Optionally, the composition for skin conditioning, whitening and brightening further comprises a pH regulator, wherein the pH regulator is 0.01-2 parts.

Optionally, the pH adjuster comprises at least one of sodium hydroxide, triethanolamine, arginine.

Optionally, in the second whitening composition, 1 to 5 parts of nicotinamide, 1 to 3 parts of arginine ferulate and 1 to 3 parts of methoxysalicylic acid potassium are mixed.

Optionally, the composition for skin conditioning, whitening and lightening further comprises 4-butylresorcinol, undecylenoyl phenylalanine and potassium methoxysalicylate.

In addition, the invention also provides an essence emulsion which is characterized by comprising the composition for regulating, whitening and brightening skin, wherein the composition for regulating, whitening and brightening skin comprises the following components: a whitening composition, a first whitening composition, and a second whitening composition;

According to the technical scheme, based on modern theoretical research, free radical theory, DNA repair and other theory are applied, factors influencing skin color and aging are comprehensively considered, and comprehensive conditioning is performed from four directions of antioxidation, ultraviolet resistance, anti-saccharification and whitening, so that skin aging and blackening caused by skin oxidization, ultraviolet injury, skin saccharification, melanin precipitation and the like are improved, skin presents a good state, and effects of delaying aging and whitening are realized, wherein the irritation degree is tested through chick embryo experiments, an amino acid active whitening raw material 1-methyl hydantoin-2-imide is screened, and meanwhile, the double functions of inhibiting tyrosinase activity and inhibiting melanin small body transfer are realized, and the whitening effect is comparable to kojic acid; by analyzing the hydrolyzability of the amide structure, salicylic acid derivatives without whitening pathways are designed to perform a tyrosinase inhibition test according to different concentration gradients, and the two can be used for synergistically enhancing the tyrosinase inhibition rate through data comparison.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a graph showing the comparison of the day 0 and the day 84 after the use of the skin conditioning, whitening and brightening composition according to example 1 of the present invention;

FIG. 2 is a schematic representation of the reaction scheme with ethylene glycol salicylate addition;

FIG. 3 is a schematic representation of the reaction scheme of ethylene glycol salicylate and ethylene glycol salicylate bimolecular polyethers;

FIG. 4 is a comparative graph of experimental testing procedures of chick embryo chorioallantoic membranes.

The achievement of the objects, functional features and advantages of the present invention will be further described with reference to the accompanying drawings, in conjunction with the embodiments.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention. In addition, the meaning of "and/or" as it appears throughout includes three parallel schemes, for example "A and/or B", including the A scheme, or the B scheme, or the scheme where A and B are satisfied simultaneously. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be regarded as not exist and not within the protection scope of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In view of the above, the present invention provides a composition for skin conditioning, whitening and lightening, comprising the following components: a whitening composition, a first whitening composition, and a second whitening composition; wherein the whitening composition comprises a polyhydric alcohol and a salicylic acid derivative; the first whitening composition comprises an amino acid derivative and water, wherein the amino acid derivative comprises at least one of 1-methyl hydantoin-2-imide, octanoylglycine and octanoylsalicylic acid; the second whitening composition includes niacinamide, arginine ferulate, and potassium methoxysalicylate.

According to the technical scheme, based on modern theoretical research, free radical theory, DNA repair and other theory are applied, factors influencing skin color and aging are comprehensively considered, and comprehensive conditioning is performed from four directions of antioxidation, ultraviolet resistance, anti-saccharification and whitening, so that skin aging and blackening caused by skin oxidization, ultraviolet injury, skin saccharification, melanin precipitation and the like are improved, skin presents a good state, and effects of delaying aging and whitening are realized, wherein the irritation degree is tested through chick embryo experiments, an amino acid active whitening raw material 1-methyl hydantoin-2-imide is screened, and meanwhile, the double functions of inhibiting tyrosinase activity and inhibiting melanin small body transfer are realized, and the whitening effect is comparable to kojic acid; by analyzing the hydrolyzability of the amide structure, salicylic acid derivatives without whitening pathways are designed to perform a neuraminidase inhibition test according to different concentration gradients, and the two can synergistically increase the neuraminidase inhibition rate through data comparison.

It should be noted that the specific type of the salicylic acid derivative is not limited, as long as the whitening effect can be increased, and in some embodiments, the salicylic acid derivative is glycol salicylate; the polyol may be 1, 2-pentanediol, may be ethoxydiglycol, may be 1, 3-butanediol, or may be 1, 3-propanediol.

Specifically, the hydrolysis reaction of 1-methyl hydantoin-2-imide can occur under certain conditions, the cyclic structure of the 1-methyl hydantoin-2-imide is changed from cyclic to linear, the structure is a hydrolysis state of amino acid (the amino acid is an ampholyte, the pH value of a solution is called isoelectric point when the amino acid mainly exists in a dipole ion form), and due to the introduction of uncontrollable factors, a certain amount of glycol salicylate is needed, and the amount of decomposed salicylic acid with a certain concentration can promote the cyclic to linear amino acid structure ratio, so that the glycol salicylate with a certain concentration can accelerate the conversion of 1-methyl hydantoin-2-imide molecules with the cyclic structure to linear in the hydrolysis state, and improve the isoelectric point effect of the amino acid, thereby playing the role of whitening and enhancing effects. The inventor research tests show that in the whitening composition, 1-30 parts of 1, 2-pentanediol and 1-5 parts of ethylene glycol salicylate.

Ethylene glycol salicylate is taken as a salicylic acid derivative, a passage on a sun-screening surface of the salicylic acid derivative has a whitening effect, but the hydrolysis states of the salicylic acid derivative under different states are analyzed to obtain the following reversible reaction of the structure of the salicylic acid derivative in pure oil and aqueous solution:

when glycol salicylate is added, the dehydration condensation reaction of hydroxyl of glycol salicylate generates two molecular formula ether structures (shown in figure 2), and the oily component of long chain ether structure increases its water solubility, thereby improving possible hydrolysis state.

Further, glycol salicylate and glycol salicylate bimolecular polyether in aqueous solution undergo corresponding hydrolysis process under certain conditions, the reaction which can exist in the process (as shown in fig. 3), and due to alcohol solubility of glycol salicylate, the concentration gradient is set as follows: with the same concentration of 1-methylhydantoin-2-imide, the PI value of the solution after the whole solution passes the test can obviously show that ionization balance in the solution is promoted to the forward direction along with the increase of the concentration of glycol salicylate, so that the conclusion can be made that the glycol salicylate promotes the forward hydrolysis of 1-methylhydantoin-2-imide.

Specifically, in the present embodiment, the polyol is 1, 2-pentanediol; in the whitening composition, the concentration of the 1, 2-pentanediol is 1-25 g/mL, and the concentration of the ethylene glycol salicylate is 1-4.5 g/mL.

The experimental protocol was set based on the concentration ranges and the proportion fractions described above: the more the linear amino acid structure is, the larger the PI value is, and the forward reaction degree of the hydrolyzed linear amino acid is shown by measuring the PI value of glycol salicylate and non-glycol salicylate under the same 1-methylhydantoin-2-imide state.

The experimental steps are as follows: by adding water and alcohol, other polyols can be used instead of dissolving and dispersing for complete dispersion, and both are not dispersed and added into the application formula.

TABLE 1

From the above data, it can be derived that: the PI value of the 1-methyl hydantoin-2-imide can be improved by a certain amount of glycol salicylate, the isoelectric point of crystallization of the glycol salicylate is improved, and the forward promotion of active ingredients is increased, so that the glycol salicylate can cooperate with the 1-methyl hydantoin-2-imide to realize whitening synergy.

In some embodiments, the 1-methylhydantoin-2-imide comprises 1-methylhydantoin-2-imide and the water comprises ultrapure water; in the first whitening composition, the 1-methylhydantoin-2-imide is 0.1 to 10 parts, and the ultrapure water is 5 to 50 parts.

Based on the above two control characterization indexes of high dosage and strong stimulation, the stimulation is tested by chick embryo experiments, and the 1-methylhydantoin-2-imide which is an amino acid active whitening raw material is screened out, and simultaneously has the dual functions of inhibiting tyrosinase activity and inhibiting melanosome transfer, and the whitening effect is comparable to kojic acid. By analyzing the hydrolyzability of the amide structure, the ethylene glycol salicylate without whitening pathway is designed to perform human efficacy tests according to different concentration gradients, and the two can synergistically increase the inhibition rate of the neuraminidase by data comparison, and refer to table 1 and fig. 4.

Wherein, table 2 shows the results of chick embryo chorioallantoic membrane experiments, and table 3 shows the scoring criteria.

TABLE 2 results of chick embryo chorioallantoic membrane experiments

TABLE 3 scoring criteria

Scoring of	Phenomenon (1)
		0 point	No reaction occurs for 3min and 30min
1 minute	3min without reaction, 30min with flocculent diffuse bleeding
		2 minutes	3min, a small amount of flocculent diffuse bleeding occurs
3 minutes	3min, massive diffuse bleeding occurred
		4 minutes	3min, massive diffuse bleeding accompanied with blood spots
5 minutes	3min, massive diffuse bleeding accompanied by large blood clot and blackening blood vessel

Based on the 1-methyl hydantoin-2-imide and glycol salicylate according to a certain component ratio, the composition can be used for a cutin stripping test, a comparison test is carried out by setting whether the glycol salicylate exists, 1-methyl hydantoin-2-imide is denoted as A, 1-methyl hydantoin-2-imide and glycol salicylate composition is denoted as B, the composition is prepared according to the formula design method, the content of 1-methyl hydantoin-2-imide is 2 parts, 2 parts of 1-methyl hydantoin-2-imide and 1 part of glycol salicylate are arranged in the B, and a comparison test experiment is carried out, so that the two components of the glycol salicylate and the 1-methyl hydantoin-2-imide can synergistically improve the tyrosinase inhibition rate, and the whitening and synergistic functions are achieved.

Further, in some embodiments, tyrosinase inhibition (i.e., the test substance is at the same concentration as described above) is tested in accordance with the A, B packet described above, specifically, during the actual test, the test is performed in accordance with the following steps:

s1: the test substance was diluted into multi-stage concentration samples with disodium hydrogen phosphate-citric acid buffer, respectively.

S2: and (3) adding 0.5mL of tyrosinase solution into the sample tube (T) and the enzyme reaction tube (C), respectively replacing the sample background (T0) and the solvent background (C0) with 0.5mL of disodium hydrogen phosphate-citric acid buffer solution, fully and uniformly mixing the sample and tyrosinase, and incubating for 10 minutes in a water bath at 37 ℃. 2mL of levodopa solution was added to each tube in sequence, the reaction time of each tube was controlled to 5 minutes, and after the reaction was completed, each tube of the reaction solution was transferred to a cuvette, and the absorbance was measured at 475 nm.

The loading operation is shown in Table 3:

TABLE 3 tyrosinase inhibition assay sample addition protocol

The inhibition results of tyrosinase by each group of test substances were calculated according to formula 1, inhibition ratio (%) = [1 (T-T ₀ )/(C-C ₀ )]X 100%; wherein T is the absorbance of the sample tube (i.e. the absorbance of the solution after the reaction of the sample with tyrosinase), T ₀ For the background absorbance of the sample, C is the absorbance of the enzyme reaction tube (i.e., the absorbance of the solution of tyrosinase and dopa in the absence of sample) and C ₀ Is the background absorbance of the solvent.

From the test results, it can be derived that: the tyrosinase inhibition rate (80.34%) of the 1-methylhydantoin-2-imide, ethylene glycol salicylate compositions was significantly higher than that of 1-methylhydantoin-2-imide alone (60.24%) at the same test concentration (2%).

Further, in some embodiments, the composition for skin conditioning, whitening and lightening further comprises a pH adjuster, wherein the pH adjuster is 0.01-2 parts. The purpose of adding the pH adjuster is to stabilize the formulation, so the pH adjuster may be selectively added according to the application or scene.

Further, the type of the pH adjuster is not limited, and is preferably an adjuster commonly used for neutralization in daily life, specifically, sodium hydroxide solution, salicylic acid solution, citric acid, sodium citrate, a mixture of citric acid and sodium citrate, and triethanolamine.

In some embodiments, in the second whitening composition, the nicotinamide is 1-5 parts, the arginine ferulate is 1-3 parts, and the potassium methoxysalicylate is 1-3 parts.

Specifically, in some embodiments, the composition for skin conditioning, whitening and lightening further comprises 4-butylresorcinol, undecylenoyl phenylalanine and a potassium methoxysalicylate.

In addition, the invention also provides the essence emulsion which comprises the composition for regulating, whitening and brightening skin.

The essence emulsion also comprises the following components: 1-10 parts of glycerin, 0.02 part of EDTA disodium, 0.5-5 parts of xanthan gum, 0.2-2 parts of sodium hyaluronate, 1-3 parts of ethylhexyl glycerin, 1-3 parts of 1,2 hexanediol and 5-20 parts of a composition for regulating, whitening and brightening skin (namely the composition for regulating, whitening and brightening skin provided by the invention).

The essence emulsion can be prepared according to the following method: mixing glycerol, EDTA disodium, xanthan gum, sodium hyaluronate, ethylhexyl glycerol, 1, 2-hexanediol and deionized water, stirring at 80deg.C, rapidly homogenizing for 5min to uniformity, and stirring at constant temperature; and cooling to 50 ℃, adding the composition for regulating, whitening and brightening the skin, mixing and stirring uniformly, and discharging to obtain the essence emulsion.

The following technical solutions of the present invention will be described in further detail with reference to specific examples and drawings, and it should be understood that the following examples are only for explaining the present invention and are not intended to limit the present invention.

Example 1

Composition components for skin conditioning, whitening and brightening: 15 parts of 1, 2-pentanediol, 3 parts of ethylene glycol salicylate, 10 parts of ultrapure water, 5 parts of 1-methyl hydantoin-2-imide, 0.12 part of pH regulator, 3 parts of nicotinamide, 0.5 part of arginine ferulate and 1 part of potassium methoxysalicylate.

The preparation method comprises the following steps:

(1) Dissolving 1-methylhydantoin-2-imide with 5 parts of ultrapure water, uniformly dispersing by ultrasonic, and marking the solution A after the 1-methylhydantoin-2-imide is completely dispersed into a transparent solution;

(2) Dispersing glycol salicylate into 1, 2-pentanediol to obtain solution B;

(3) Dissolving nicotinamide, arginine ferulate and potassium methoxysalicylate with the rest ultrapure water, mixing with a pH regulator, and marking as a solution C;

(4) Mixing the solution A and the solution C (the ratio is 10:9.62) according to the clarity to obtain a composition for regulating, whitening and brightening skin;

(5) Mixing glycerol, EDTA disodium, xanthan gum, sodium hyaluronate, ethylhexyl glycerol, 1, 2-hexanediol and deionized water, stirring at 80deg.C, rapidly homogenizing for 5min to uniformity, and stirring at constant temperature; and cooling to 50 ℃, adding the composition for regulating, whitening and brightening the skin, mixing and stirring uniformly, and discharging to obtain the essence emulsion.

Example 2

The preparation method comprises the following steps:

(2) Dispersing glycol salicylate into 1, 2-pentanediol to obtain solution B;

(4) Mixing the solution A, the solution B and the solution C (the ratio is 10:18:9.62) according to the clarity to obtain a composition for regulating, whitening and brightening skin;

Example 3

The preparation method comprises the following steps:

(2) Dispersing glycol salicylate into 1, 2-pentanediol to obtain solution B;

(4) Mixing the solution B and the solution C (the ratio is 18:9.62) according to the clarity to obtain a composition for regulating, whitening and brightening skin;

Example 4

Composition components for skin conditioning, whitening and brightening: 10 parts of 1, 2-pentanediol, 2 parts of ethylene glycol salicylate, 10 parts of ultrapure water, 5 parts of 1-methyl hydantoin-2-imide, 0.09 part of pH regulator, 3 parts of nicotinamide, 0.5 part of arginine ferulate and 2 parts of potassium methoxysalicylate.

The preparation method comprises the following steps:

(2) Dispersing glycol salicylate into 1, 2-pentanediol to obtain solution B;

(4) Mixing the solution A, the solution B and the solution C (the ratio is 10:12:9.59) according to the clarity to obtain a composition for regulating, whitening and brightening skin;

Example 5

The preparation method comprises the following steps:

(2) Dispersing glycol salicylate into 1, 2-pentanediol to obtain solution B;

(4) Mixing the solution A and the solution B (the ratio is 10:18) according to the clarity to obtain a composition for regulating, whitening and brightening skin;

Performance testing

Experimental instrument: skin physiological index test instrument-MC 760 (German CK Co.), grease tape (German CK Co.), mercuric chloride buffer (German CK Co.), potassium chloride buffer (German CK Co.).

The experimental object: 75 oil-sensitive skin groups with statistical significance and serious facial compliance with red areas are selected, obvious skin problems such as pigmentation, desquamation and the like caused by inflammation are caused, and age and sex are selected to be consistent as much as possible through data analysis of exfoliation, tolerance value analysis, oil secretion and pH value analysis.

1. Repair test

Dividing the experimental subjects into 5 groups, wherein each group is 15 individuals, measuring the face characterization parameter values before use, and five groups of testers use the essence milk provided in the embodiment 1 to 5 of the invention respectively, and testing the use condition after 84 days; wherein the desquamation, erythema and dryness severity (mean ± SD) were evaluated using a 10cm visual analog scale (reported in mm) by taking the desquamation, erythema and dryness as characterization parameters, and the specific test results are shown in table 4.

Table 4 test results

From table 4, it can be derived that: the essential milks provided in examples 1 to 5 can improve skin problems such as desquamation and erythema dryness, and can be laterally explained that the combination can accelerate the renewal rate of the horny layer without negative irritation to the skin, and can be explained that the essential milks have a skin repairing effect by erythema and dryness.

2. Index of oil secretion

(1) Principle of measuring secretion of fat

The sebum measurement principle is based on the photometer principle of a special adhesive tape, and the extinction adhesive tape with the thickness of about 0.1mm can become a semitransparent adhesive tape after absorbing grease on human skin, the light transmission amount of the extinction adhesive tape can be changed, and the more the absorbed grease, the larger the light transmission amount is, so that the content of the grease on the skin can be measured. The oil test method is recognized by the world science community as a simple indirect measurement result of sebaceous gland secretion, and can be used for distinguishing different skin types so as to accurately know the oil change caused by internal and external reasons (the oil secretion amount of dry skin groups at the cheek is less than 70 mug/cm < 2 >, the oil secretion amount of normal skin groups is 70-150 mug/cm < 2 >, and the oil secretion amount of oily skin is more than 150 mug/cm < 2 >).

(2) Method for measuring secretion of fat

Before measuring the grease, correcting by using a standard value and ensuring that an adhesive tape on a sebum measuring probe is in an unused state, inserting a discussion into a corresponding sebum testing hole on a host machine, pressing a button on a handle, displaying a probe on a computer screen, taking out the probe, counting down the screen, measuring the probe at an angle of 90 degrees with the skin to be measured for 30 seconds, and reinserting the probe into the host machine by using a prompt tone by using an instrument, and gently pressing the obtained sebum value, wherein the unit of the measured value is that the range of the value is 0-350 mu g/cm ² Between them.

3. pH value index

(1) principle of pH value test

The pH value measuring principle is that the top end of a probe which is integrated with a glass electrode and a reference electrode is formed by a semi-permeable membrane of glass, the semi-permeable membrane separates the measured solution formed by the inner buffer solution and the outer skin surface, but the hydrogen ions in the outer measured solution can measure the corresponding pH value through the semi-permeable membrane. (the pH of the dry skin population at the cheek is 5.7-6.5, the pH of the normal skin population is 4.5-5.5, and the pH of the oily skin population is 3.5-4.3)

(2) Measurement method

And (3) calibrating the measuring instrument by using a standard solution with pH value of 7.0 and 4.0, firstly soaking a tested probe in a potassium chloride buffer solution, and when the test is prepared, cleaning the probe by using distilled water, wherein a proper amount of distilled water is reserved on the probe, and the excessive or the insufficient water indicated by the probe influences the accuracy of a detection result to cause errors. And starting an operation program, and then forming a 90-degree angle between the probe and the skin to be measured to measure the pressure moderately, wherein excessive pressure can lead to water loss between the probe and the skin, so that the accuracy of a result is affected. After a few seconds the result of the measurement is displayed on a computer screen. The units of the measured values are in the range of 0-12. (3)

(3) pH value measurement conditions

The measurement is carried out indoors, no sunlight is directly emitted, the room temperature is kept at 20-24 ℃, and the relative humidity of air is kept at 40% -60%. Before measurement, the person to be tested is instructed to wash the face with warm water, and the person to be tested is not required to use any cosmetics, and the person to be tested is waited to measure in a waiting room for keeping the skin in a natural state for 2 hours. When in measurement, a tested person takes a probe of a sitting or lying position measuring instrument to vertically contact with the skin surface of the measuring part for proper time to read and record the value. The measurement points of the fat secretion in the region of the skin with high fat secretion and the cheek on the other side of the skin with high fat and PH values are taken as the average value of the two measurement points.

The same test sample is used for testing, so that the oil content and the pH value of the face of the oil-sensitive skin tested human group are obviously different as shown in the table 5, and the oil-sensitive skin tested human group has statistical significance.

Table 5 test data

As can be seen from table 1, the essential milk prepared in examples 1 to 5 is maintained, the amount of grease is significantly reduced, and the pH accuracy range is gradually stabilized, so that the composition for skin conditioning, whitening and brightening provided by the invention can reduce the problems of skin yellowing caused by grease, pigmentation caused by skin inflammation and sensitivity caused by skin pH.

4. Tracking return visit

The above 5 groups of tested persons were followed and interviewed to self-evaluate the overall facial status, and the number of decimal places was retained according to the average value of the score of the total number of persons, and the test results obtained are shown in table 6 and fig. 1 (wherein, in table 6, 0=aggravated, 1=unchanged, 2=stable, 3=improved).

TABLE 6 test results

Days of use	Example 1	Example 2	Example 3	Example 4	Example 5
						7	1	2	1.3	1.8	1
15	2	2.3	2	2	1.8
						30	2.1	2.8	2	2.3	2
42	2.5	3	2.5	2.8	2.5
						56	3	3	3	3	3
64	3	3	3	3	3
						84	3	3	3	3	3

As can be seen from table 1 and fig. 1, the composition for skin conditioning, whitening and brightening provided by the present invention can improve skin conditions, and the skin conditions of the tested person are significantly improved compared with those before use.

The foregoing is merely a preferred embodiment of the present invention and is not intended to limit the scope of the present invention, but various modifications and variations will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. A composition for skin conditioning, whitening and lightening, comprising the following components: a whitening composition, a first whitening composition, and a second whitening composition;

wherein the whitening composition comprises a polyol and glycol salicylate;

the first whitening composition includes 1-methylhydantoin-2-imide and water;

the second whitening composition comprises nicotinamide, arginine ferulate, and potassium methoxysalicylate;

wherein, glycol salicylate is 1-5 parts, 1-methyl hydantoin-2-imide is 0.1-10 parts, nicotinamide is 1-5 parts, arginine ferulate is 1-3 parts, and methoxy potassium salicylate is 1-3 parts.

2. The composition for skin conditioning, whitening and brightening of claim 1, wherein the polyol comprises any one of 1, 2-pentanediol, ethoxydiglycol, 1, 3-butanediol and 1, 3-propanediol.

3. The skin conditioning, whitening and brightening composition according to claim 1, wherein the polyhydric alcohol comprises 1, 2-pentanediol, and the 1, 2-pentanediol is 1 to 30 parts in the whitening composition.

4. The composition for skin conditioning, whitening and brightening according to claim 1, wherein the water comprises ultrapure water in an amount of 5 to 50 parts in the first whitening composition.

5. The skin conditioning, whitening and brightening composition according to claim 1, further comprising a pH adjustor, wherein the pH adjustor is 0.01 to 2 parts.

6. The composition for skin conditioning, whitening and brightening of claim 5, wherein the pH adjuster comprises at least one of sodium hydroxide, triethanolamine, arginine.

7. The skin conditioning, whitening and brightening composition of claim 1, further comprising 4-butylresorcinol, undecylenoyl phenylalanine and potassium methoxysalicylate.

8. An essential emulsion comprising the composition for skin conditioning, whitening and lightening as claimed in any one of claims 1 to 7.