CN108743431A - A kind of small-molecular peptides facial mask of anti-ageing beauty treatment and preparation method thereof - Google Patents
A kind of small-molecular peptides facial mask of anti-ageing beauty treatment and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses a kind of small-molecular peptides facial masks of anti-ageing beauty treatment and preparation method thereof, contain following component：Egg white peptide, soya-bean polypeptides, pawpaw zymotic fluid, blueberry zymotic fluid, forsythia suspense extraction, Periostracum Cicadae extract, Flos Rosae Rugosae extract, lemon, Argireline, vitamin E, sodium hyaluronate, avenabeta glucosan, menthol, lecithin, hydroxypropyl cellulose, methyl hydroxybenzoate, EDETATE SODIUM, paraben esters, remaining be distilled water.The small-molecular peptides facial mask of anti-ageing beauty treatment provided by the invention, it is mainly used for the anti-ageing smoothing wrinkle of face, but the effect of skin whitening, moisturizing is also had both simultaneously, increase skin elasticity with nontoxic, non-stimulated, hypo-allergenic, desalination wrinkle, enhancing cell viability, keeps skin fine and smooth, smooth, glossy, anti crease and anti senile significant effect, it is without any side effects, securely and reliably, antiallergy is suitable for various skin quality, can be used as the long-time service of facial mask class skin-protection product.
Description
Technical field
The invention belongs to beauty and skin care technical fields, and in particular to a kind of small-molecular peptides facial mask of anti-ageing beauty treatment and its preparation
Method.
Background technology
With the improvement of living standards, consumer has higher requirement to skin-protection product, especially protected in Asia beauty
The skin-protection product in skin market, anti-ageing beauty treatment is that middle aged consumer pays close attention to the most.But skin care item market at present, anti-ageing beauty treatment
Facial mask generally existing needed for effect component is single, product stability is poor, anti-wrinkle effect is bad, even there is toxic side effect etc. lacks
It falls into.
Invention content
The present invention provides a kind of small-molecular peptides facial masks of anti-ageing beauty treatment and preparation method thereof.Select egg white peptide, soybean more
Peptide and other plant extracts coordinate pawpaw zymotic fluid and blueberry zymotic fluid with antioxidation as effective ingredient,
The superoxide radical and hydroxyl radical free radical inside skin can be removed, smooth fine lines, compact skin, and can be that skin carries out deeply simultaneously
Layer moisturizing, bright color.
The technical solution that the present invention takes is：
A kind of small-molecular peptides facial mask of anti-ageing beauty treatment, which is characterized in that the ingredient containing following weight percent：Egg white peptide
3~8%, soya-bean polypeptides 2~6%, pawpaw zymotic fluid 10~20%, blueberry zymotic fluid 20~40%, forsythia suspense extraction 1.0~
3.0%, Periostracum Cicadae extract 0.3~1.2%, Flos Rosae Rugosae extract 0.5~1.5%, lemon 0.3~1.5%, acetyl group 6
Peptide -8 0.05~0.15%, vitamin E 0.03~0.30%, sodium hyaluronate 0.03~0.28%, avenabeta glucosan 0.02~
0.35%, menthol 0.11~0.26%, lecithin 0.05~0.20%, hydroxypropyl cellulose 0.03~0.12, methyl hydroxybenzoate
0.003~0.08%, EDETATE SODIUM 0.004~0.020%, paraben esters 0.01~0.03%, remaining be distilled water.
Further, it is preferable to be the ingredient containing following weight percent：Egg white peptide 4~6%, soya-bean polypeptides 3.6~
5.1%, pawpaw zymotic fluid 12~18%, blueberry zymotic fluid 25~35%, forsythia suspense extraction 1.4~2.3%, Periostracum Cicadae extract
0.5~1.0%, Flos Rosae Rugosae extract 0.8~1.3%, lemon 0.6~1.1%, Argireline 0.08~
0.12%, vitamin E 0.10~0.22%, sodium hyaluronate 0.04~0.18%, avenabeta glucosan 0.2~0.5%, menthol
0.14~0.20%, lecithin 0.07~0.16%, hydroxypropyl cellulose 0.06~0.10%, methyl hydroxybenzoate 0.005~
0.05%, EDETATE SODIUM 0.006~0.015%, paraben esters 0.016~0.026%, remaining be distilled water.
The preparation method of the egg white peptide is：By egg white according to weight ratio 1:2~3 mix with distilled water, according to mixed liquor
Total amount access 0.25~0.50% trypsase and 0.15~0.40% alkali protease, 4~6 are digested at 55~60 DEG C
Hour, egg white peptide is made through membrane filtration, concentration, spray drying in enzymolysis liquid.
The preparation method of the pawpaw zymotic fluid is：After pawpaw peeling, removing flesh, 3~5 times of pawpaw weight is added in stripping and slicing
Water crush, acquired solution is placed in fermentation tank, according to 1.0 × 107~1.0 × 10 × 108The inoculum concentration of cfu/mL accesses
28~32 DEG C of 24~48h of fermentation of saccharomycete, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the pawpaw zymotic fluid.
The preparation method of the blueberry zymotic fluid is：It is directly crushed after fresh blueberry is cleaned, then according to solid-liquid ratio 1:5
~8 mix with distilled water, and acquired solution is placed in fermentation tank, according to 1.0 × 108~1.0 × 10 × 109The inoculum concentration of cfu/mL
28~32 DEG C of 24~48h of fermentation of saccharomycete are accessed, the solution for the gained that ferments is through filtering, sterilizing, you can obtain the blueberry fermentation
Liquid.
The preparation method of the forsythia suspense extraction is：Fructus Forsythiae is crushed, according to solid-liquid ratio 1:3~5 mix with dichloromethane,
Then supercritical carbon dioxide extracting is carried out, after, product obtains forsythia suspense extraction after being concentrated under reduced pressure, being freeze-dried.Make
The active constituent content of the Fructus Forsythiae extracted with dichloromethane is high, and has stronger antioxidant activity and bacteriostasis.
The condition of the supercritical carbon dioxide extracting is：55~60 DEG C, 35~40MPa of pressure of temperature, carbon dioxide stream
Speed is 3~4mL/min, and extraction time is 3~3.5h.
The preparation method of the Periostracum Cicadae extract is：After cicada slough is cleaned, be put into the water of 5~8 times of weight impregnate 0.5~
1.0h then heats to 95~100 DEG C of 1~2h of decoction, collects decoction liquor, the cicada is can be obtained after being concentrated under reduced pressure, drying
Slough off extract.Cicada slough is the shell after the black grasshopper of cicada sprouts wings, and contains a large amount of chitins and protein, amino acid, cicada slough tool
There are dispelling wind-heat, promoting eruption relieving sore-throat, removing nebula for improving eyesight, expelling wind and relieving convulsion and other effects, is decocted ingredient for skin care kind, there is anti-mistake
Quick effect.
The preparation method of the Flos Rosae Rugosae extract is：Fresh rose is won, 1.5~3 times of rose weight are put into
Dew in impregnate 2~3h, then squeezed the juice using wall-breaking machine, juice concentrates the filtrate to original heavy through five layers of filtered through gauze
The 5~10% of amount, you can obtain the Flos Rosae Rugosae extract.In the slurries of rose containing there are many skin care ingredient, have quercitrin,
Amaroid, fat, tannin, vitamin etc. have anti-aging skin whitening effect.Especially with the dew for containing the Nature essence
Squeeze the juice after extraction, has effects that potent moisturizing and nourishing.
The present invention also provides the preparation method of the small-molecular peptides facial mask of the anti-ageing beauty treatment, the preparation method includes
Following steps：
S1, by the Argireline of formula ratio, vitamin E, sodium hyaluronate, avenabeta glucosan, menthol, lecithin,
Hydroxypropyl cellulose, methyl hydroxybenzoate, EDETATE SODIUM, paraben esters, its be added in distilled water, be warming up to 65~75 DEG C, stirring
It reacts to all dissolution of raw material；
S2, by near 55~60 DEG C of temperature, be added while stirring the egg white peptide of formula ratio, soya-bean polypeptides, forsythia suspense extraction,
Periostracum Cicadae extract continues 20~30min of stirring；
S3, temperature is cooled to 25~30 DEG C, pawpaw zymotic fluid, blueberry zymotic fluid, the rose extraction of formula ratio is added
Object and lemon, through microwave sterilization after stirring evenly, you can obtain the nutritive water of small-molecular peptides facial mask；
S4, under sterile environment, facial mask cloth is impregnated into 20~30min in nutritive water, then to the facial mask after immersion
Cloth is sealed packaging, you can obtains the small-molecular peptides facial mask with anti-ageing beautifying function.
The facial mask cloth is silk mask, plant fiber facial mask, carbon black facial mask, non-woven fabrics facial mask, Biofibre facial mask, shell
One kind in glycan facial mask.
In the formula of the small-molecular peptides facial mask of anti-ageing beauty treatment provided by the invention, egg white peptide and soya-bean polypeptides are to utilize the modern times
Biotechnology of enzymes engineering is easy to skin suction since its molecular weight is small by the breaks down proteins in egg white and soybean at small-molecular peptides
It receives, cell proliferation can be accelerated, promote skin metabolism, Cucumber Extract；Small-molecular peptides enter inside skin, play moisturizing because
The effect of son, can lock skin moisture, deep layer moisturizing, and have the function of tender skin, anti-oxidant, anti-aging.
Pawpaw zymotic fluid is obtained after saccharomycetes to make fermentation in formula, and a large amount of pawpaw sulfydryl enzyme can be generated after fermented,
It is a kind of active factors with high bioactivity, and there are a large amount of sulfhydryl-group activity (SH) group on strand, it can have
Superoxide radical and hydroxyl radical free radical in human body are removed in effect ground, the content of lipid peroxide in skin are effectively reduced, to prevent
The aging of body cell enables the aging course of skin to delay；And after everfermentation, the method molecular substance in nutritional ingredient
It is broken down into small molecule, the more conducively sorption enhanced of skin；It is rich in anthocyanidin and phenolic acid in blueberry, is that pure natural anti-aging is sought
Support replenishers and antioxidant activity agent, it is fermented after blueberry nutrient substance be easier by percutaneous absorption.Lemon fragrance
Pure and fresh, the limonene in lemon has effects that whitening, convergence, Bergamot Mint Extract, can remove old dead cell, and become clear skin
Color, consolidation capilary promote collagen to generate, and desalinate melanin.
6 peptide -8 of acetyl group and sodium hyaluronate have higher antiwrinkle active.Vitamin E has preferable moisture-keeping functions；Oat
Beta glucan has activation to the macrophage in human skin, and collagen and elastin laminin in skin can be promoted to increase
Add, so as to improve skin appearance；On the one hand the addition of menthol can coordinate with lemon, improve the sensory experience of nutritive water,
On the other hand, menthol is a kind of cutaneous permeable agent, and face skin can be promoted for the absorption of nutritive water in facial mask, is that skin is deep
Layer moisturizing；The stability of facial mask can be improved in the addition of the auxiliary materials such as lecithin.
In the formula of the small-molecular peptides facial mask of anti-ageing beauty treatment provided by the invention, egg white peptide, soya-bean polypeptides, pawpaw fermentation
Liquid, blueberry zymotic fluid, forsythia suspense extraction, rose words extract, lemon all have certain antioxidant activity, are formulated in addition
In the crease-resistant ingredient of Argireline and sodium hyaluronate, can deep layer fight skin aging, also added natural antiallergy in formula
Periostracum Cicadae extract and promote Transdermal absorption menthol；Above each mutual comprehensive function of composition, contributes to nutritive water deeply to ooze
Saturating skin, locks skin moisture, and the awake skin vigor of ferment improves elasticity of skin, fights skin aging problem.
The small-molecular peptides facial mask of anti-ageing beauty treatment provided by the invention is mainly used for the anti-ageing smoothing wrinkle of face, but also simultaneous simultaneously
The effect for having skin whitening, moisturizing, in ingredient by egg white peptide, soya-bean polypeptides combine each natural extract together function as effectively at
Point, have it is nontoxic, non-stimulated, hypo-allergenic, desalination wrinkle, enhancing cell viability increase skin elasticity, make skin it is fine and smooth, it is smooth,
Glossy, anti crease and anti senile significant effect is without any side effects, and safe and reliable, antiallergy is suitable for various skin quality, can be used as face
Film class skin-protection product is used for a long time.
Specific implementation mode
The following describes the present invention in detail with reference to examples.
Embodiment 1
A kind of small-molecular peptides facial mask of anti-ageing beauty treatment, the ingredient containing following weight percent：Egg white peptide 5%, soybean are more
Peptide 4.0%, pawpaw zymotic fluid 15%, blueberry zymotic fluid 28%, forsythia suspense extraction 1.8%, Periostracum Cicadae extract 0.7%, rose
Extract 1.0%, lemon 0.9%, Argireline 0.10%, vitamin E 0.16%, sodium hyaluronate 0.12%, swallow
Wheat beta glucan 0.4%, menthol 0.19%, lecithin 0.11%, hydroxypropyl cellulose 0.08%, methyl hydroxybenzoate 0.02%,
EDETATE SODIUM 0.010%, paraben esters 0.020%, remaining be distilled water.
The preparation method of the egg white peptide is：By egg white according to weight ratio 1:2 mix with distilled water, according to the total of mixed liquor
Amount access 0.25% trypsase and 0.40% alkali protease, digests 6 hours at 55 DEG C, and enzymolysis liquid is through membrane filtration, dense
Egg white peptide is made in contracting, spray drying.
The preparation method of the pawpaw zymotic fluid is：After pawpaw peeling, removing flesh, the water of 4 times of pawpaw weight is added in stripping and slicing
It crushes, acquired solution is placed in fermentation tank, according to 1.0 × 107Inoculum concentration access 28 DEG C of fermentations of saccharomycete of cfu/mL
48h, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the pawpaw zymotic fluid.
The preparation method of the blueberry zymotic fluid is：It is directly crushed after fresh blueberry is cleaned, then according to solid-liquid ratio 1:7
It is mixed with distilled water, acquired solution is placed in fermentation tank, according to 1.0 × 109Inoculum concentration access 28 DEG C of hairs of saccharomycete of cfu/mL
Ferment 48h, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the blueberry zymotic fluid.
The preparation method of the forsythia suspense extraction is：Fructus Forsythiae is crushed, according to solid-liquid ratio 1:3 mix with dichloromethane, so
After carry out supercritical carbon dioxide extracting, after, product obtains forsythia suspense extraction after being concentrated under reduced pressure, being freeze-dried.It is described
The condition of supercritical carbon dioxide extracting is：55 DEG C, pressure 35MPa, carbon dioxide flow rate 3mL/min of temperature, extraction time
For 3h.
The preparation method of the Periostracum Cicadae extract is：After cicada slough is cleaned, it is put into the water of 6 times of weight and impregnates 0.5h, so
After be warming up to 100 DEG C decoction 1h, collect decoction liquor, the Periostracum Cicadae extract is can be obtained after being concentrated under reduced pressure, drying.
The preparation method of the Flos Rosae Rugosae extract is：Fresh rose is won, the dew of 3 times of rose weight is put into
Middle immersion 3h, is then squeezed the juice using wall-breaking machine, and juice concentrates the filtrate to original ponderable 10% through five layers of filtered through gauze,
It can be obtained the Flos Rosae Rugosae extract.
The preparation method of the small-molecular peptides facial mask of the anti-ageing beauty treatment, includes the following steps：
S1, by the Argireline of formula ratio, vitamin E, sodium hyaluronate, avenabeta glucosan, menthol, lecithin,
Hydroxypropyl cellulose, methyl hydroxybenzoate, EDETATE SODIUM, paraben esters, its be added in distilled water, be warming up to 75 DEG C, be stirred to react
To all dissolution of raw material；
S2, by near 60 DEG C of temperature, the egg white peptide of formula ratio, soya-bean polypeptides, forsythia suspense extraction, cicada slough are added while stirring
Extract continues 20~30min of stirring；
S3, temperature is cooled to 30 DEG C, be added the pawpaw zymotic fluid of formula ratio, blueberry zymotic fluid, Flos Rosae Rugosae extract and
Lemon, through microwave sterilization after stirring evenly, you can obtain the nutritive water of small-molecular peptides facial mask；
S4, under sterile environment, silk mask cloth is impregnated into 20~30min in nutritive water, then to immersion after
Facial mask cloth is sealed packaging, you can obtains the small-molecular peptides facial mask with anti-ageing beautifying function.
Embodiment 2
A kind of small-molecular peptides facial mask of anti-ageing beauty treatment, the ingredient containing following weight percent：Egg white peptide 3%, soybean are more
Peptide 2%, pawpaw zymotic fluid 10%, blueberry zymotic fluid 20%, forsythia suspense extraction 1.0%, Periostracum Cicadae extract 0.5%, rose carry
Take object 0.5%, lemon 0.7%, Argireline 0.05%, vitamin E 0.03%, sodium hyaluronate 0.12%, oat
Beta glucan 0.06%, menthol 0.14%, lecithin 0.09%, hydroxypropyl cellulose 0.08, methyl hydroxybenzoate 0.005%,
EDETATE SODIUM 0.007%, paraben esters 0.016%, remaining be distilled water.
The preparation method of the egg white peptide is：By egg white according to weight ratio 1:3 mix with distilled water, according to the total of mixed liquor
Amount access 0.50% trypsase and 0.20% alkali protease, digests 4 hours at 60 DEG C, and enzymolysis liquid is through membrane filtration, dense
Egg white peptide is made in contracting, spray drying.
The preparation method of the pawpaw zymotic fluid is：After pawpaw peeling, removing flesh, the water of 5 times of pawpaw weight is added in stripping and slicing
It crushes, acquired solution is placed in fermentation tank, according to 1.0 × 108Inoculum concentration access 32 DEG C of fermentations of saccharomycete of cfu/mL
For 24 hours, the solution obtained by fermenting is through filtering, sterilizing, you can obtains the pawpaw zymotic fluid.
The preparation method of the blueberry zymotic fluid is：It is directly crushed after fresh blueberry is cleaned, then according to solid-liquid ratio 1:8
It is mixed with distilled water, acquired solution is placed in fermentation tank, according to 1.0 × 108Inoculum concentration access 32 DEG C of hairs of saccharomycete of cfu/mL
For 24 hours, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the blueberry zymotic fluid for ferment.
The preparation method of the forsythia suspense extraction is：Fructus Forsythiae is crushed, according to solid-liquid ratio 1:5 mix with dichloromethane, so
After carry out supercritical carbon dioxide extracting, after, product obtains forsythia suspense extraction after being concentrated under reduced pressure, being freeze-dried.It is described
The condition of supercritical carbon dioxide extracting is：55 DEG C, pressure 35MPa, carbon dioxide flow rate 4mL/min of temperature, extraction time
For 3.5h.
The preparation method of the Periostracum Cicadae extract is：After cicada slough is cleaned, it is put into the water of 8 times of weight and impregnates 1.0h, so
After be warming up to 100 DEG C decoction 2h, collect decoction liquor, the Periostracum Cicadae extract is can be obtained after being concentrated under reduced pressure, drying.
The preparation method of the Flos Rosae Rugosae extract is：Fresh rose is won, the dew of 2 times of rose weight is put into
Middle immersion 2.5h, is then squeezed the juice using wall-breaking machine, and juice concentrates the filtrate to original ponderable 7% through five layers of filtered through gauze,
It can be obtained the Flos Rosae Rugosae extract.
The preparation method of the small-molecular peptides facial mask of the anti-ageing beauty treatment, includes the following steps：
S1, by the Argireline of formula ratio, vitamin E, sodium hyaluronate, avenabeta glucosan, menthol, lecithin,
Hydroxypropyl cellulose, methyl hydroxybenzoate, EDETATE SODIUM, paraben esters, its be added in distilled water, be warming up to 65 DEG C, be stirred to react
To all dissolution of raw material；
S2, by near 55 DEG C of temperature, the egg white peptide of formula ratio, soya-bean polypeptides, forsythia suspense extraction, cicada slough are added while stirring
Extract continues 20~30min of stirring；
S3, temperature is cooled to 25 DEG C, be added the pawpaw zymotic fluid of formula ratio, blueberry zymotic fluid, Flos Rosae Rugosae extract and
Lemon, through microwave sterilization after stirring evenly, you can obtain the nutritive water of small-molecular peptides facial mask；
S4, under sterile environment, carbon black facial mask cloth is impregnated into 20~30min in nutritive water, then to immersion after
Facial mask cloth is sealed packaging, you can obtains the small-molecular peptides facial mask with anti-ageing beautifying function.
Embodiment 3
A kind of small-molecular peptides facial mask of anti-ageing beauty treatment, the ingredient containing following weight percent：Egg white peptide 8%, soybean are more
Peptide 6%, pawpaw zymotic fluid 20%, blueberry zymotic fluid 40%, forsythia suspense extraction 3.0%, Periostracum Cicadae extract 1.2%, rose carry
Take object 1.5%, lemon 1.5%, Argireline 0.15%, vitamin E 0.30%, sodium hyaluronate 0.28%, oat
Beta glucan 0.35%, menthol 0.26%, lecithin 0.20%, hydroxypropyl cellulose 0.12, methyl hydroxybenzoate 0.08%, EDTA
Disodium 0.020%, paraben esters 0.03%, remaining be distilled water.
The preparation method of the egg white peptide is：By egg white according to weight ratio 1:3 mix with distilled water, according to the total of mixed liquor
Amount access 0.30% trypsase and 0.20% alkali protease, digests 4 hours at 60 DEG C, and enzymolysis liquid is through membrane filtration, dense
Egg white peptide is made in contracting, spray drying.
The preparation method of the pawpaw zymotic fluid is：After pawpaw peeling, removing flesh, the water of 5 times of pawpaw weight is added in stripping and slicing
It crushes, acquired solution is placed in fermentation tank, according to 1.0 × 107Inoculum concentration access 32 DEG C of fermentations of saccharomycete of cfu/mL
For 24 hours, the solution obtained by fermenting is through filtering, sterilizing, you can obtains the pawpaw zymotic fluid.
The preparation method of the blueberry zymotic fluid is：It is directly crushed after fresh blueberry is cleaned, then according to solid-liquid ratio 1:8
It is mixed with distilled water, acquired solution is placed in fermentation tank, according to 1.0 × 108Inoculum concentration access 28 DEG C of hairs of saccharomycete of cfu/mL
Ferment 48h, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the blueberry zymotic fluid.
The preparation method of the forsythia suspense extraction is：Fructus Forsythiae is crushed, according to solid-liquid ratio 1:5 mix with dichloromethane, so
After carry out supercritical carbon dioxide extracting, after, product obtains forsythia suspense extraction after being concentrated under reduced pressure, being freeze-dried.It is described
The condition of supercritical carbon dioxide extracting is：Temperature 60 C, pressure 35MPa, carbon dioxide flow rate 3mL/min, extraction time
For 3h.
The preparation method of the Periostracum Cicadae extract is：After cicada slough is cleaned, it is put into the water of 6 times of weight and impregnates 0.5h, so
After be warming up to 95 DEG C decoction 2h, collect decoction liquor, the Periostracum Cicadae extract is can be obtained after being concentrated under reduced pressure, drying.
The preparation method of the Flos Rosae Rugosae extract is：Fresh rose is won, the dew of 1.5 times of rose weight is put into
2.5h is impregnated in water, is then squeezed the juice using wall-breaking machine, and juice concentrates the filtrate to former ponderable through five layers of filtered through gauze
8%, you can obtain the Flos Rosae Rugosae extract.
The preparation method of the small-molecular peptides facial mask of the anti-ageing beauty treatment, includes the following steps：
S1, by the Argireline of formula ratio, vitamin E, sodium hyaluronate, avenabeta glucosan, menthol, lecithin,
Hydroxypropyl cellulose, methyl hydroxybenzoate, EDETATE SODIUM, paraben esters, its be added in distilled water, be warming up to 75 DEG C, be stirred to react
To all dissolution of raw material；
S2, by near 55 DEG C of temperature, the egg white peptide of formula ratio, soya-bean polypeptides, forsythia suspense extraction, cicada slough are added while stirring
Extract continues 20~30min of stirring；
S3, temperature is cooled to 25 DEG C, be added the pawpaw zymotic fluid of formula ratio, blueberry zymotic fluid, Flos Rosae Rugosae extract and
Lemon, through microwave sterilization after stirring evenly, you can obtain the nutritive water of small-molecular peptides facial mask；
S4, under sterile environment, non-woven fabrics facial mask cloth is impregnated into 20~30min in nutritive water, then to immersion after
Facial mask cloth be sealed packaging, you can obtain the small-molecular peptides facial mask with anti-ageing beautifying function.
Embodiment 4
Using effect is evaluated
The female volunteers 300 that the age is randomly selected at 30~45 years old make the small-molecular peptides facial mask cloth in the present invention
It is evaluated with effect, every group is 100, and application method is：Application after cleaning face before sleeping, application time are 20min, two days
Application is primary, continuously sticks 30 days, then statistical appraisal result.98% trier reacts using after facial mask disclosed by the invention
Elasticity, the glossiness of skin increase, and have apparent whitening anti-wrinkling effect, and through moisture teller test every time using after facial mask
Skin moisture content has apparent moistening effect compared with that can increase by 100% or more before use.
The above-mentioned detailed description that a kind of small-molecular peptides facial mask of anti-ageing beauty treatment and preparation method thereof is carried out with reference to embodiment,
It is illustrative without being restrictive, several embodiments can be enumerated according to limited range, therefore do not departing from this hair
Change and modification under bright general plotting should belong within protection scope of the present invention.
Claims (10)
1. a kind of small-molecular peptides facial mask of anti-ageing beauty treatment, which is characterized in that the ingredient containing following weight percent：Egg white peptide 3
~8%, soya-bean polypeptides 2~6%, pawpaw zymotic fluid 10~20%, blueberry zymotic fluid 20~40%, forsythia suspense extraction 1.0~
3.0%, Periostracum Cicadae extract 0.3~1.2%, Flos Rosae Rugosae extract 0.5~1.5%, lemon 0.3~1.5%, acetyl group six
Peptide -8 0.05~0.15%, vitamin E 0.03~0.30%, sodium hyaluronate 0.03~0.28%, avenabeta glucosan 0.02~
0.35%, menthol 0.11~0.26%, lecithin 0.05~0.20%, hydroxypropyl cellulose 0.03~0.12%, oxybenzene first
Ester 0.003~0.08%, EDETATE SODIUM 0.004~0.020%, paraben esters 0.01~0.03%, remaining be distilled water.
2. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 1, which is characterized in that contain following weight percent
Ingredient：Egg white peptide 4~6%, soya-bean polypeptides 3.6~5.1%, pawpaw zymotic fluid 12~18%, blueberry zymotic fluid 25~35%,
Forsythia suspense extraction 1.4~2.3%, Periostracum Cicadae extract 0.5~1.0%, Flos Rosae Rugosae extract 0.8~1.3%, lemon 0.6
~1.1%, Argireline 0.08~0.12%, vitamin E 0.10~0.22%, sodium hyaluronate 0.04~0.18%, swallow
Wheat beta glucan 0.2~0.5%, menthol 0.14~0.20%, lecithin 0.07~0.16%, hydroxypropyl cellulose 0.06~
0.10%, methyl hydroxybenzoate 0.005~0.05%, EDETATE SODIUM 0.006~0.015%, paraben esters 0.016~0.026%, its
Remaining is distilled water.
3. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 1 or 2, which is characterized in that the pawpaw zymotic fluid
Preparation method be：After pawpaw peeling, removing flesh, stripping and slicing, the water that 3~5 times of pawpaw weight is added crushes, and acquired solution is set
In fermentation tank, according to 1.0 × 107~1.0 × 10 × 10828~32 DEG C of fermentations 24 of inoculum concentration access saccharomycete of cfu/mL~
48h, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the pawpaw zymotic fluid.
4. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 1 or 2, which is characterized in that the blueberry zymotic fluid
Preparation method be：It is directly crushed after fresh blueberry is cleaned, then according to solid-liquid ratio 1:5~8 mix with distilled water, and gained is molten
Liquid is placed in fermentation tank, according to 1.0 × 108~1.0 × 10 × 109Inoculum concentration access 28~32 DEG C of fermentations of saccharomycete of cfu/mL
24~48h, the solution for the gained that ferments is through filtering, sterilizing, you can obtains the blueberry zymotic fluid.
5. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 1 or 2, which is characterized in that the forsythia suspense extraction
Preparation method be：Fructus Forsythiae is crushed, according to solid-liquid ratio 1:3~5 mix with dichloromethane, then carry out supercritical carbon dioxide
Extraction, after, product obtains forsythia suspense extraction after being concentrated under reduced pressure, being freeze-dried.
6. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 4, which is characterized in that the supercritical carbon dioxide
The condition of extraction is：55~60 DEG C, 35~40MPa of pressure of temperature, carbon dioxide flow rate are 3~4mL/min, extraction time 3
~3.5h.
7. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 1 or 2, which is characterized in that the Periostracum Cicadae extract
Preparation method be：After cicada slough is cleaned, it is put into 0.5~1.0h of immersion in the water of 5~8 times of weight, then heats to 95~100
DEG C decoct 1~2h, collect decoction liquor, the Periostracum Cicadae extract is can be obtained after being concentrated under reduced pressure, drying.
8. the small-molecular peptides facial mask of anti-ageing beauty treatment according to claim 1 or 2, which is characterized in that the rose extraction
The preparation method of object is：Fresh rose is won, is put into 2~3h of immersion in the dew of 1.5~3 times of rose weight, then
It is squeezed the juice using wall-breaking machine, juice concentrates the filtrate to original ponderable 5~10% through five layers of filtered through gauze, you can obtains institute
State Flos Rosae Rugosae extract.
9. the preparation method of the small-molecular peptides facial mask of anti-ageing beauty treatment according to any one of claims 1 to 8, feature exist
In the preparation method comprises the following steps：
S1, by the Argireline of formula ratio, vitamin E, sodium hyaluronate, avenabeta glucosan, menthol, lecithin, hydroxypropyl
Base cellulose, methyl hydroxybenzoate, EDETATE SODIUM, paraben esters, its be added in distilled water, be warming up to 65~75 DEG C, be stirred to react
To all dissolution of raw material；
S2, by near 55~60 DEG C of temperature, the egg white peptide of formula ratio, soya-bean polypeptides, forsythia suspense extraction, cicada slough are added while stirring
Extract continues 20~30min of stirring；
S3, temperature is cooled to 25~30 DEG C, be added the pawpaw zymotic fluid of formula ratio, blueberry zymotic fluid, Flos Rosae Rugosae extract and
Lemon, through microwave sterilization after stirring evenly, you can obtain the nutritive water of small-molecular peptides facial mask；
S4, under sterile environment, facial mask cloth is impregnated into 20~30min in nutritive water, then to the facial mask cloth after immersion into
Row packs, you can obtains the small-molecular peptides facial mask with anti-ageing beautifying function.
10. preparation method according to claim 8, which is characterized in that the facial mask cloth is silk mask, plant fiber face
One kind in film, carbon black facial mask, non-woven fabrics facial mask, Biofibre facial mask, chitosan facial mask.
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| CN201810840998.4A CN108743431B (en) | 2018-07-27 | 2018-07-27 | Anti-aging and beautifying small-molecule peptide mask and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522662A (en) * | 2019-08-29 | 2019-12-03 | 福州东星生物技术有限公司 | A kind of ganoderma lucidum face cream and preparation method thereof |
| CN111728910A (en) * | 2020-07-03 | 2020-10-02 | 广州无添加主义化妆品有限公司 | Fermented extract of blueberry and snow lotus herb, preparation method and application thereof |
| CN112618610A (en) * | 2019-10-07 | 2021-04-09 | 大江生医股份有限公司 | Papaya fermented juice and use thereof for improving skin condition |
| CN112716864A (en) * | 2021-03-03 | 2021-04-30 | 李培丰 | Rose whitening and moisturizing mask |
-
2018
- 2018-07-27 CN CN201810840998.4A patent/CN108743431B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522662A (en) * | 2019-08-29 | 2019-12-03 | 福州东星生物技术有限公司 | A kind of ganoderma lucidum face cream and preparation method thereof |
| CN112618610A (en) * | 2019-10-07 | 2021-04-09 | 大江生医股份有限公司 | Papaya fermented juice and use thereof for improving skin condition |
| CN111728910A (en) * | 2020-07-03 | 2020-10-02 | 广州无添加主义化妆品有限公司 | Fermented extract of blueberry and snow lotus herb, preparation method and application thereof |
| CN112716864A (en) * | 2021-03-03 | 2021-04-30 | 李培丰 | Rose whitening and moisturizing mask |
| CN112716864B (en) * | 2021-03-03 | 2022-12-16 | 山东博科医用材料有限公司 | Rose whitening and moisturizing mask |
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| Publication number | Publication date |
|---|---|
| CN108743431B (en) | 2021-05-14 |
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