CN108175741A - A kind of anti-aging beauty-care frost and preparation method thereof - Google Patents
A kind of anti-aging beauty-care frost and preparation method thereof Download PDFInfo
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- CN108175741A CN108175741A CN201810249683.2A CN201810249683A CN108175741A CN 108175741 A CN108175741 A CN 108175741A CN 201810249683 A CN201810249683 A CN 201810249683A CN 108175741 A CN108175741 A CN 108175741A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/86—Products or compounds obtained by genetic engineering
Abstract
The invention discloses a kind of anti-aging beauty-care frosts and preparation method thereof, are made of the raw material of following parts by weight：1~4 part of butter fruit stem cell extract, 0.05~2 part of eryngo general flavone, 0.5~1.5 part of plant extracts, 3~9 parts of magnesium ascorbyl phosphate, 81~3 parts of acetyl group hexapeptide, 1~3 part of palmitoyl oligopeptide, 31~2 parts of palmityl tetrapeptide, 1~2 part of tocopherol, 0.05~2.55 part of Sodium Hyaluronate, 2~4 parts of xanthans, 0.2~0.3 part of bi-imidazolidinyl urea, 0.1~0.2 part of allantoin, 0.02~0.08 part of tetra- sodium of EDTA, 0.02~0.03 part of sodium pyrosulfite, 8~14 parts of butanediol, deionized water is to 100 parts, aging caused by natural cause or non-natural factor can effectively be slowed down and reduction color spot, the skin symptoms such as tanned, and safe and non-stimulating property.
Description
Technical field
The invention belongs to technical field of cosmetic preparation, and in particular to a kind of anti-aging beauty-care frost and preparation method thereof.
Background technology
Skin aging is as caused by natural cause or non-natural factor, shows as cutis laxa, wrinkle, blood vessel expansion occurs
, keratinization of epidermis is bad, abnormality proliferation occur, the denaturation of corium elastomer and catabolite accumulation etc..Wrinkle is skin aging
A kind of mark, be referred to as " annual ring of life ".However everybody has a love of beauty, particularly female consumer, always not
The disconnected anti-aging for pursuing better and safer removes wrinkle product.Common saying says a white screening semen pharbitidis, has said white-skinned face function and has disappeared for women
It is also the emphasis of concern for the person of expense.Therefore, the anti-aging cosmetics of whitening are increasingly taken seriously, safety and both effectiveness
Nature is evaluated as consumer and manufacturer emphasis of interest.Skin care item type is various on the market at present, and effect is different, including
Whitening, moisturizing, nti-freckle and anti-aging etc..Though but many products are more or less added to some harmful chemical substances
These right substances have the skin of people the skin care effects such as short-term whitening and anti-aging, but if being used for a long time, can make skin instead
It is severely damaged, there is long acne, color spot and fat secretion imbalance etc..
Invention content
To solve the above-mentioned problems, the present invention provides a kind of anti-aging beauty-care frost and preparation method thereof, can effectively slow down
Aging caused by natural cause or non-natural factor and the skin symptoms such as reduction color spot, tanned.
To achieve these goals, shown in technical scheme is as follows：
A kind of anti-aging beauty-care frost, is made of the raw material of following parts by weight：1~4 part of butter fruit stem cell extract, thorn
0.05~2 part of celery general flavone, 0.5~1.5 part of plant extracts, 3~9 parts of magnesium ascorbyl phosphate, Argireline 1~
3 parts, 1~3 part of palmitoyl oligopeptide, -31~2 parts of palmityl tetrapeptide, 1~2 part of tocopherol, 0.05~2.55 part of Sodium Hyaluronate,
2~4 parts of xanthans, 0.2~0.3 part of bi-imidazolidinyl urea, 0.1~0.2 part of allantoin, 0.02~0.08 part of tetra- sodium of EDTA, coke
0.02~0.03 part of sodium sulfite, 8~14 parts of butanediol, deionized water is to 100 parts.
Preferably, a kind of anti-aging beauty-care frost of the present invention, is made of the raw material of following parts by weight：Butter fruit stem cell carries
Take 1.75~3.25 parts of object, 0.538~1.513 part of eryngo general flavone, 0.75~1.25 part of plant extracts, ascorbic acid phosphoric acid
4.5~7.5 parts of ester magnesium, 1.5~2.5 parts of Argireline, 1.5~2.5 parts of palmitoyl oligopeptide, palmityl tetrapeptide -31.25~
1.75 parts, 1.25~1.75 parts of tocopherol, 0.675~1.925 part of Sodium Hyaluronate, 2.5~3.5 parts of xanthans, double imidazolidines
0.225~0.275 part of base urea, 0.125~0.175 part of allantoin, 0.035~0.065 part of tetra- sodium of EDTA, sodium pyrosulfite
0.023~0.028 part, 9.5~12.5 parts of butanediol, deionized water is to 100 parts.
It is highly preferred that a kind of anti-aging beauty-care frost of the present invention, is made of the raw material of following parts by weight：Butter fruit stem cell
2.5 parts of extract, 1.025 parts of eryngo general flavone, 1 part of plant extracts, 6 parts of magnesium ascorbyl phosphate, Argireline 2
Part, 2 parts of palmitoyl oligopeptide, -31.5 parts of palmityl tetrapeptide, 1.5 parts of tocopherol, 1.3 parts of Sodium Hyaluronate, 3 parts of xanthans, double miaows
0.25 part of oxazolidinyl urea, 0.15 part of allantoin, 0.05 part of tetra- sodium of EDTA, 0.025 part of sodium pyrosulfite, 11 parts of butanediol, go from
Sub- water is to 100 parts.
A kind of anti-aging beauty-care frost of the present invention, the plant extraction liquid are made of the raw material of following parts by weight：Blueberry spends 5
~10 parts, 10~20 parts of seaweed, 10~25 parts of green tea, 0.5~2.5 part of wooden fish stone powder.
Preferably, the plant extraction liquid is made of the raw material of following parts by weight：Blueberry spends 6.25~8.75 parts, seaweed
12.5~17.5 parts, 13.75~21.25 parts of green tea, 1~2 part of wooden fish stone powder.
It is highly preferred that the plant extraction liquid is made of the raw material of following parts by weight：Blueberry spend 7.5 parts, 15 parts of seaweed,
17.5 parts of green tea, 1.5 parts of wooden fish stone powder.
Further, the preparation method of the plant extracts is：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 50~80 mesh sieve by weight, is 1 by solid-liquid ratio:8~
10 add in 80~90% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 225~275W 40~50min of ultrasonic extraction；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
A kind of anti-aging beauty-care frost of the present invention, the preparation method of the butter fruit stem cell extract include the following steps：
(1) butter fruit new life branch is collected, cleaning is cut into 4~5cm, is impregnated in the L-AA of 60~100mg/L
5~11min uses aseptic water washing after being put into 60~90% 5~11min of alcohol solution dipping, is then placed in 25~35% mistake
20min is impregnated in oxidation aqueous solution of hydrogen, then with aseptic water washing 15min；
(2) butter fruit body material bast is removed, is put into containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
MS solid mediums on light culture, cultivation temperature is 25~30 DEG C, and culture humidity is 70~80%, incubation time for 19~
21d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of the activated carbon of casein and 2mg/L, cultivation temperature are 28~32 DEG C, cultivate rotating speed
100~140r/min, incubation time are 18~22d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, identical with squamous subculture holding
Temperature and rotating speed, totally 8~12d；
(5) it collects and expands the obtained butter fruit stem cell of culture, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then
Defrosting 30min, repeatedly 2 times after 20~30 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:4~6
70~80% absolute ethyl alcohols are added in, in 28~32 DEG C of stirring 8~12h of extraction, through strong Ultrasonic Pulverization cytoplasm, ultrasonic extraction liquid mistake
Filtrate is collected after filter, concentrates, be drying to obtain.
A kind of anti-aging beauty-care frost of the present invention, the preparation method of the eryngo general flavone are：Eryngo is weighed to dry, pulverize
50~80 mesh sieve, and are 1 by solid-liquid ratio:20~30 add in 70~80% absolute ethyl alcohols, and intermittent type microwave is carried out under 200~220W
Heating, every 10~15s intervals are extracted 1 time, extract 60~70s altogether, filter, and wash filter residue with 70~90% absolute ethyl alcohols, close
And all filtrate liquid remove ethyl alcohol, are freeze-dried to obtain eryngo general flavone in 70~90 DEG C of rotary evaporations.
The present invention prepares a kind of method of anti-aging beauty-care frost, includes the following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palm fibre
Palmitic acid acyl oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase,
Carry out homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
Relative to the prior art, beneficial effects of the present invention are：
(1) anti-aging beauty-care frost provided by the invention natural activity skin care ingredient containing there are many, especially contains butter fruit
Stem cell extract and eryngo general flavone can not only effectively inhibit staphylococcus aureus and Bacillus subtillis, and cause
Skin care item are easy to be less readily available for absorption by the skin, and accelerate self more raw and reparation of skin, safe and efficient, can effectively improve skin dimness nothing
The problems such as light, pigment deposition, coarse and aging, makes skin brilliant white, exquisiteness flexible, has good whitening and moisturizing and anti-aging
Effect.
(2) wooden fish stone powder in anti-aging beauty-care frost of the present invention contains a variety of the essential trace elements of the human bodys and minerals, such as
Strontium, selenium, zinc, metasilicic acid, copper, cobalt, germanium etc. have very strong health care and beautification function, can adjust the metabolism of human body, remove face
Portion's cell generates waste, prevention and the generation and development for reducing bacterial fungus.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1
A kind of anti-aging beauty-care frost, is made of the raw material of following parts by weight：2.5 parts of butter fruit stem cell extract, thorn
1.025 parts of celery general flavone, 1 part of plant extracts, 6 parts of magnesium ascorbyl phosphate, 2 parts of Argireline, palmitoyl oligopeptide 2
Part, -31.5 parts of palmityl tetrapeptide, 1.5 parts of tocopherol, 1.3 parts of Sodium Hyaluronate, 3 parts of xanthans, bi-imidazolidinyl urea 0.25
Part, 0.15 part of allantoin, 0.05 part of tetra- sodium of EDTA, 0.025 part of sodium pyrosulfite, 11 parts of butanediol, deionized water is to 100 parts.
A kind of anti-aging beauty-care frost of the present embodiment, the plant extraction liquid are made of the raw material of following parts by weight：Blueberry
Spend 7.5 parts, 15 parts of seaweed, 17.5 parts of green tea, 1.5 parts of wooden fish stone powder.
Further, the preparation method of the plant extracts is：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 65 mesh sieve by weight, is 1 by solid-liquid ratio:9 add in
85% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 250W ultrasonic extraction 45min；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the butter fruit stem cell extract include following step
Suddenly：
(1) butter fruit new life branch is collected, cleaning is cut into 4.5cm, impregnates 8min in the L-AA of 80mg/L,
Aseptic water washing is used after being put into 75% alcohol solution dipping 8min, is then placed in 30% aqueous hydrogen peroxide solution and impregnates
20min, then with aseptic water washing 15min；
(2) butter fruit body material bast is removed, is put into containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
MS solid mediums on light culture, cultivation temperature be 27.5 DEG C, culture humidity be 75%, incubation time 20d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of the activated carbon of casein and 2mg/L, cultivation temperature are 30 DEG C, culture rotating speed 120r/
Min, incubation time 20d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, identical with squamous subculture holding
Temperature and rotating speed, common 10d；
(5) it collects and expands the obtained butter fruit stem cell of culture, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then
Defrosting 30min, repeatedly 2 times after 25 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:5 add in 75%
Absolute ethyl alcohol, in 30 DEG C of stirring extraction 10h, through strong Ultrasonic Pulverization cytoplasm, ultrasonic extraction liquid filtering and collecting filter liquid, concentration,
It is drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the eryngo general flavone are：Eryngo is weighed to dry, pulverize
65 mesh sieve is crossed, is 1 by solid-liquid ratio:25 add in 75% absolute ethyl alcohol, the progress intermittent type microwave heating under 210W, between every 12.5s
It has a rest and extracts 1 time, extract 65s altogether, filter, and filter residue is washed with 80% absolute ethyl alcohol, merge all filtrate liquid and steamed in 80 DEG C of rotations
Hair removes ethyl alcohol, is freeze-dried to obtain eryngo general flavone.
The present embodiment prepares a kind of method of anti-aging beauty-care frost, includes the following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palm fibre
Palmitic acid acyl oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase,
Carry out homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
Embodiment 2
A kind of anti-aging beauty-care frost, is made of the raw material of following parts by weight：1 part of butter fruit stem cell extract, eryngo
0.05 part of general flavone, 0.5 part of plant extracts, 3 parts of magnesium ascorbyl phosphate, 1 part of Argireline, palmitoyl oligopeptide 1
Part, -31 parts of palmityl tetrapeptide, 1 part of tocopherol, 0.05 part of Sodium Hyaluronate, 2 parts of xanthans, 0.2 part of bi-imidazolidinyl urea, urine
0.1 part of Bursin, 0.02 part of tetra- sodium of EDTA, 0.02 part of sodium pyrosulfite, 8 parts of butanediol, deionized water is to 100 parts.
A kind of anti-aging beauty-care frost of the present embodiment, the plant extraction liquid are made of the raw material of following parts by weight：Blueberry
Spend 5 parts, 10 parts of seaweed, 10 parts of green tea, 0.5 part of wooden fish stone powder.
Further, the preparation method of the plant extracts is：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 50 mesh sieve by weight, is 1 by solid-liquid ratio:8 add in
80% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 225W ultrasonic extraction 40min；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the butter fruit stem cell extract include following step
Suddenly：
(1) butter fruit new life branch is collected, cleaning is cut into 4cm, impregnates 5min in the L-AA of 60mg/L, put
Aseptic water washing is used after entering 60% alcohol solution dipping 5min, is then placed in 25% aqueous hydrogen peroxide solution and impregnates 20min,
Aseptic water washing 15min is used again；
(2) butter fruit body material bast is removed, is put into containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
MS solid mediums on light culture, cultivation temperature be 25 DEG C, culture humidity be 70%, incubation time 19d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of the activated carbon of casein and 2mg/L, cultivation temperature are 28 DEG C, culture rotating speed 100r/
Min, incubation time 18d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, identical with squamous subculture holding
Temperature and rotating speed, common 8d；
(5) it collects and expands the obtained butter fruit stem cell of culture, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then
Defrosting 30min, repeatedly 2 times after 20 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:4 add in 70%
Absolute ethyl alcohol, in 28 DEG C of stirring extraction 8h, through strong Ultrasonic Pulverization cytoplasm, ultrasonic extraction liquid filtering and collecting filter liquid, concentration is done
It is dry to obtain the final product.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the eryngo general flavone are：Eryngo is weighed to dry, pulverize
50 mesh sieve is crossed, is 1 by solid-liquid ratio:20 add in 70% absolute ethyl alcohol, and intermittent type microwave heating is carried out under 200W, the interval per 10s
Extraction 1 time, extracts 60s altogether, filters, and washs filter residue with 70% absolute ethyl alcohol, merges all filtrate liquid in 70 DEG C of rotary evaporations,
Ethyl alcohol is removed, is freeze-dried to obtain eryngo general flavone.
The present embodiment prepares a kind of method of anti-aging beauty-care frost, includes the following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palm fibre
Palmitic acid acyl oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase,
Carry out homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
Embodiment 3
A kind of anti-aging beauty-care frost, is made of the raw material of following parts by weight：4 parts of butter fruit stem cell extract, eryngo
2 parts of general flavone, 1.5 parts of plant extracts, 9 parts of magnesium ascorbyl phosphate, 3 parts of Argireline, 3 parts of palmitoyl oligopeptide,
- 32 parts of palmityl tetrapeptide, 2 parts of tocopherol, 2.55 parts of Sodium Hyaluronate, 4 parts of xanthans, 0.3 part of bi-imidazolidinyl urea, allantoin
0.2 part, 0.08 part of tetra- sodium of EDTA, 0.03 part of sodium pyrosulfite, 14 parts of butanediol, deionized water is to 100 parts.
A kind of anti-aging beauty-care frost of the present embodiment, the plant extraction liquid are made of the raw material of following parts by weight：Blueberry
Spend 10 parts, 20 parts of seaweed, 25 parts of green tea, 2.5 parts of wooden fish stone powder.
Further, the preparation method of the plant extracts is：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 80 mesh sieve by weight, is 1 by solid-liquid ratio:10 add in
90% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 275W ultrasonic extraction 50min；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the butter fruit stem cell extract include following step
Suddenly：
(1) butter fruit new life branch is collected, cleaning is cut into 5cm, impregnates 11min in the L-AA of 100mg/L,
Aseptic water washing is used after being put into 90% alcohol solution dipping 11min, is then placed in 35% aqueous hydrogen peroxide solution and impregnates
20min, then with aseptic water washing 15min；
(2) butter fruit body material bast is removed, is put into containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
MS solid mediums on light culture, cultivation temperature be 30 DEG C, culture humidity be 80%, incubation time 21d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of the activated carbon of casein and 2mg/L, cultivation temperature are 32 DEG C, culture rotating speed 140r/
Min, incubation time 22d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, identical with squamous subculture holding
Temperature and rotating speed, common 12d；
(5) it collects and expands the obtained butter fruit stem cell of culture, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then
Defrosting 30min, repeatedly 2 times after 30 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:6 add in 80%
Absolute ethyl alcohol, in 32 DEG C of stirring extraction 12h, through strong Ultrasonic Pulverization cytoplasm, ultrasonic extraction liquid filtering and collecting filter liquid, concentration,
It is drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the eryngo general flavone are：Eryngo is weighed to dry, pulverize
80 mesh sieve is crossed, is 1 by solid-liquid ratio:30 add in 80% absolute ethyl alcohol, and intermittent type microwave heating is carried out under 220W, the interval per 15s
Extraction 1 time, extracts 70s altogether, filters, and washs filter residue with 90% absolute ethyl alcohol, merges all filtrate liquid in 90 DEG C of rotary evaporations,
Ethyl alcohol is removed, is freeze-dried to obtain eryngo general flavone.
The present embodiment prepares a kind of method of anti-aging beauty-care frost, includes the following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palm fibre
Palmitic acid acyl oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase,
Carry out homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
Embodiment 4
A kind of anti-aging beauty-care frost, is made of the raw material of following parts by weight：1.75 parts of butter fruit stem cell extract, thorn
0.538 part of celery general flavone, 0.75 part of plant extracts, 4.5 parts of magnesium ascorbyl phosphate, 1.5 parts of Argireline, palm
It is 1.5 parts of acyl oligopeptides, -31.25 parts of palmityl tetrapeptide, 1.25 parts of tocopherol, 0.675 part of Sodium Hyaluronate, 2.5 parts of xanthans, double
0.225 part of imidazolidinyl urea, 0.125 part of allantoin, 0.035 part of tetra- sodium of EDTA, 0.023 part of sodium pyrosulfite, butanediol 9.5
Part, deionized water is to 100 parts.
A kind of anti-aging beauty-care frost of the present embodiment, the plant extraction liquid are made of the raw material of following parts by weight：Blueberry
Spend 6.25 parts, 12.5 parts of seaweed, 13.75 parts of green tea, 1 part of wooden fish stone powder.
Further, the preparation method of the plant extracts is：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 50 mesh sieve by weight, is 1 by solid-liquid ratio:8 add in
80% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 225W ultrasonic extraction 40min；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the butter fruit stem cell extract include following step
Suddenly：
(1) butter fruit new life branch is collected, cleaning is cut into 4cm, impregnates 5min in the L-AA of 60mg/L, put
Aseptic water washing is used after entering 60% alcohol solution dipping 5min, is then placed in 25% aqueous hydrogen peroxide solution and impregnates 20min,
Aseptic water washing 15min is used again；
(2) butter fruit body material bast is removed, is put into containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
MS solid mediums on light culture, cultivation temperature be 25 DEG C, culture humidity be 70%, incubation time 19d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of the activated carbon of casein and 2mg/L, cultivation temperature are 28 DEG C, culture rotating speed 100r/
Min, incubation time 18d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, identical with squamous subculture holding
Temperature and rotating speed, common 8d；
(5) it collects and expands the obtained butter fruit stem cell of culture, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then
Defrosting 30min, repeatedly 2 times after 20 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:4 add in 70%
Absolute ethyl alcohol, in 28 DEG C of stirring extraction 8h, through strong Ultrasonic Pulverization cytoplasm, ultrasonic extraction liquid filtering and collecting filter liquid, concentration is done
It is dry to obtain the final product.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the eryngo general flavone are：Eryngo is weighed to dry, pulverize
50 mesh sieve is crossed, is 1 by solid-liquid ratio:20 add in 70% absolute ethyl alcohol, and intermittent type microwave heating is carried out under 200W, the interval per 10s
Extraction 1 time, extracts 60s altogether, filters, and washs filter residue with 70% absolute ethyl alcohol, merges all filtrate liquid in 70 DEG C of rotary evaporations,
Ethyl alcohol is removed, is freeze-dried to obtain eryngo general flavone.
The present embodiment prepares a kind of method of anti-aging beauty-care frost, includes the following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palm fibre
Palmitic acid acyl oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase,
Carry out homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
Embodiment 5
A kind of anti-aging beauty-care frost, is made of the raw material of following parts by weight：3.25 parts of butter fruit stem cell extract, thorn
1.513 parts of celery general flavone, 1.25 parts of plant extracts, 7.5 parts of magnesium ascorbyl phosphate, 2.5 parts of Argireline, palm
It is 2.5 parts of acyl oligopeptides, -31.75 parts of palmityl tetrapeptide, 1.75 parts of tocopherol, 1.925 parts of Sodium Hyaluronate, 3.5 parts of xanthans, double
0.275 part of imidazolidinyl urea, 0.175 part of allantoin, 0.065 part of tetra- sodium of EDTA, 0.028 part of sodium pyrosulfite, butanediol 12.5
Part, deionized water is to 100 parts.
A kind of anti-aging beauty-care frost of the present embodiment, the plant extraction liquid are made of the raw material of following parts by weight：Blueberry
Spend 8.75 parts, 17.5 parts of seaweed, 21.25 parts of green tea, 2 parts of wooden fish stone powder.
Further, the preparation method of the plant extracts is：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 80 mesh sieve by weight, is 1 by solid-liquid ratio:10 add in
90% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 275W ultrasonic extraction 50min；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the butter fruit stem cell extract include following step
Suddenly：
(1) butter fruit new life branch is collected, cleaning is cut into 5cm, impregnates 11min in the L-AA of 100mg/L,
Aseptic water washing is used after being put into 90% alcohol solution dipping 11min, is then placed in 35% aqueous hydrogen peroxide solution and impregnates
20min, then with aseptic water washing 15min；
(2) butter fruit body material bast is removed, is put into containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
MS solid mediums on light culture, cultivation temperature be 30 DEG C, culture humidity be 80%, incubation time 21d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of the activated carbon of casein and 2mg/L, cultivation temperature are 32 DEG C, culture rotating speed 140r/
Min, incubation time 22d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, identical with squamous subculture holding
Temperature and rotating speed, common 12d；
(5) it collects and expands the obtained butter fruit stem cell of culture, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then
Defrosting 30min, repeatedly 2 times after 30 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:6 add in 80%
Absolute ethyl alcohol, in 32 DEG C of stirring extraction 12h, through strong Ultrasonic Pulverization cytoplasm, ultrasonic extraction liquid filtering and collecting filter liquid, concentration,
It is drying to obtain.
A kind of anti-aging beauty-care frost of the present embodiment, the preparation method of the eryngo general flavone are：Eryngo is weighed to dry, pulverize
80 mesh sieve is crossed, is 1 by solid-liquid ratio:30 add in 80% absolute ethyl alcohol, and intermittent type microwave heating is carried out under 220W, the interval per 15s
Extraction 1 time, extracts 70s altogether, filters, and washs filter residue with 90% absolute ethyl alcohol, merges all filtrate liquid in 90 DEG C of rotary evaporations,
Ethyl alcohol is removed, is freeze-dried to obtain eryngo general flavone.
The present embodiment prepares a kind of method of anti-aging beauty-care frost, includes the following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palm fibre
Palmitic acid acyl oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase,
Carry out homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
Comparative example 1
Difference lies in do not include butter fruit stem cell extract with embodiment 1 in anti-aging beauty-care frost.
Comparative example 2
Difference lies in do not include eryngo general flavone with embodiment 1 in anti-aging beauty-care frost.
Comparative example 3
Difference lies in do not include wooden fish stone powder with embodiment 1 in anti-aging beauty-care frost.
Compliance test result
1st, skin elasticity is tested：
Test equipment is the ReviscometerRV600 (elastomers of CK companies of Germany skin elasticity tester MPA580
Tested tissue is popped one's head in), it surveys five times and is averaged.
Test condition：(1) indoor environment；(2) without sunburst or light direct projection；(3) 18~22 DEG C of environment temperature, environment
Humidity 40~60%.
Test zone：Left cheekbone portion.
Testing procedure：Blank value (the R of 30min after the tested region clean of first measurement2、R5、R7), then provide 80 by
Examination person is divided into 8 groups, adheres to the anti-aging beauty-care frost using Examples 1 to 5 and comparative example 1~3 sooner or later daily, 10 by
Examination person adheres to, using existing product cosmetic cream, testing test zone skin elasticity index after 10d, 20d and 30d respectively daily sooner or later
R2、R5、R7Value (it is 450mbar that negative pressure is constant in test process), takes user's test result average value.
Index explanation：For skin elasticity index R2, R5, R7 closer to 1, the elasticity of skin is better.Wherein, R2=Ua/Uf；R5
=Ur/Ue；R7=Ur/Uf。UfFor skin maximum tension amount, UeAfter being added on skin for constant negative pressure, the stretching of skin during 0.1s
Amount, positioning elastic part amount of tension.UrAfter cancelling negative pressure, skin can restore to the original state rapidly state, equally be divided into elastic portion score value
Ur, that is, after cancelling negative pressure 0.1s, the recovery value and visco-elastic portions value or shaping part value of skin.UaFor from cancel negative pressure to
The recovery value of skin, acquired results are shown in Table 1 when follow-on test skin surface adds negative pressure again next time.
Table 1：Skin elasticity test result
As seen from Table 1, using R after the anti-aging beauty-care frost 10d of the embodiment of the present invention 1~52, R5, R7Increased
Add, the R of 20d2, R5, R7Rise apparent, the R of 30d2, R5, R7Value levels off to 1, it can be seen that, this cosmetic cream has and increases skin
Skin elasticity, senile-resistant efficacy, and its effect is more notable compared to existing cosmetic cream on the market, tightening effect is more preferable.
2nd, desalination wrinkle test
Test object is above-mentioned 90 women, observe its respectively using the embodiment of the present invention 1~5, comparative example 1~3 it is anti-
After aging cosmetic cream and existing cosmetic cream 30d, on crow's feet or forehead microgroove there are situation, test result is shown in Table 2.
Table 2：Desalinate wrinkle test result
As seen from Table 2, the anti-aging beauty-care frost of the embodiment of the present invention 1~5 has significant desalination wrinkle effect, more right
Ratio 1~3 and existing cosmetic cream effect are more preferable.
3rd, other measure of merit：
Still above-mentioned 90 women of test object, observe its respectively using the embodiment of the present invention 1~5, comparative example 1~3 it is anti-
After aging cosmetic cream and existing cosmetic cream 30d, skin improvement effects, test result is shown in Table 3.
Table 3：Skin improves result
It can be obtained by table 3, the anti-aging beauty-care frost skin improvement effects of the embodiment of the present invention 1~5 and comparative example 1~3 are apparent
Better than existing cosmetic cream, whitening spot-removing significant effect, wherein 1 Whitening, spot effect of embodiment, promote skin humidity at moistening effect
Most preferably.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.
Claims (10)
1. a kind of anti-aging beauty-care frost, which is characterized in that be made of the raw material of following parts by weight：Butter fruit stem cell extract
1~4 part, 0.05~2 part of eryngo general flavone, 0.5~1.5 part of plant extracts, 3~9 parts of magnesium ascorbyl phosphate, acetyl group
Hexapeptide -81~3 part, 1~3 part of palmitoyl oligopeptide, -31~2 parts of palmityl tetrapeptide, 1~2 part of tocopherol, Sodium Hyaluronate 0.05
~2.55 parts, 2~4 parts of xanthans, 0.2~0.3 part of bi-imidazolidinyl urea, 0.1~0.2 part of allantoin, tetra- sodium 0.02 of EDTA~
0.08 part, 0.02~0.03 part of sodium pyrosulfite, 8~14 parts of butanediol, deionized water is to 100 parts.
2. a kind of anti-aging beauty-care frost according to claim 1, which is characterized in that by the raw material group of following parts by weight
Into：1.75~3.25 parts of butter fruit stem cell extract, 0.538~1.513 part of eryngo general flavone, plant extracts 0.75~
1.25 parts, 4.5~7.5 parts of magnesium ascorbyl phosphate, 1.5~2.5 parts of Argireline, palmitoyl oligopeptide 1.5~2.5
Part, -31.25~1.75 parts of palmityl tetrapeptide, 1.25~1.75 parts of tocopherol, 0.675~1.925 part of Sodium Hyaluronate, xanthan
2.5~3.5 parts of glue, 0.225~0.275 part of bi-imidazolidinyl urea, 0.125~0.175 part of allantoin, tetra- sodium 0.035 of EDTA~
0.065 part, 0.023~0.028 part of sodium pyrosulfite, 9.5~12.5 parts of butanediol, deionized water is to 100 parts.
3. a kind of anti-aging beauty-care frost according to claim 2, which is characterized in that by the raw material group of following parts by weight
Into：2.5 parts of butter fruit stem cell extract, 1.025 parts of eryngo general flavone, 1 part of plant extracts, magnesium ascorbyl phosphate 6
Part, 2 parts of Argireline, 2 parts of palmitoyl oligopeptide, -31.5 parts of palmityl tetrapeptide, 1.5 parts of tocopherol, Sodium Hyaluronate 1.3
Part, 3 parts of xanthans, 0.25 part of bi-imidazolidinyl urea, 0.15 part of allantoin, 0.05 part of tetra- sodium of EDTA, sodium pyrosulfite 0.025
Part, 11 parts of butanediol, deionized water is to 100 parts.
4. according to a kind of anti-aging beauty-care frost of claims 1 to 3 any one of them, which is characterized in that the plant extraction liquid
It is made of the raw material of following parts by weight：Blueberry spend 5~10 parts, 10~20 parts of seaweed, 10~25 parts of green tea, wooden fish stone powder 0.5
~2.5 parts.
5. a kind of anti-aging beauty-care frost according to claim 4, which is characterized in that the plant extraction liquid is by following weight
The raw material composition of part：Blueberry spend 6.25~8.75 parts, 12.5~17.5 parts of seaweed, 13.75~21.25 parts of green tea, limonite
1~2 part of powder.
6. a kind of anti-aging beauty-care frost according to claim 5, which is characterized in that the plant extraction liquid is by following weight
The raw material composition of part：Blueberry spend 7.5 parts, 15 parts of seaweed, 17.5 parts of green tea, 1.5 parts of wooden fish stone powder.
A kind of 7. anti-aging beauty-care frost according to any one of claim 4 to 6, which is characterized in that the plant extracts
Preparation method be：
(1) blueberry flower, seaweed, green tea drying and crushing are crossed into 50~80 mesh sieve by weight, is 1 by solid-liquid ratio:8~10 add
Enter 80~90% soaked in absolute ethyl alcohol 1h；
(2) by the soak of step (1) under 225~275W 40~50min of ultrasonic extraction；
(3) step (2) extracting solution is filtered, adds in wooden fish stone powder by weight, be drying to obtain.
8. according to a kind of anti-aging beauty-care frost of claims 1 to 3 any one of them, which is characterized in that the butter dried fruit is thin
The preparation method of born of the same parents' extract includes the following steps：
(1) collect butter fruit new life branch, cleaning, be cut into 4~5cm, in the L-AA of 60~100mg/L impregnate 5~
11min uses aseptic water washing after being put into 60~90% 5~11min of alcohol solution dipping, is then placed in 25~35% peroxidating
Impregnate 20min in aqueous solution of hydrogen, then with aseptic water washing 15min；
(2) butter fruit body material bast is removed, is put into the MS containing 1mg/LNAA, 3mg/LBA and 1.5mg/L caseinhydrolysate
Light culture on solid medium, cultivation temperature are 25~30 DEG C, and culture humidity is 70~80%, and incubation time is 19~21d；
(3) squamous subculture：By cambial cell be inoculated in containing 1.5mg/L 2, the hydrolysis junket egg of BA, 2mg/L of 4-D, 2mg/L
Shaking table light culture in the MS fluid nutrient mediums of white and 2mg/L activated carbon, cultivation temperature are 28~32 DEG C, culture rotating speed 100~
140r/min, incubation time are 18~22d；
(4) by the cell line of squamous subculture with 1 × 104The inoculum density of/mL expands culture, keeps mutually synthermal with squamous subculture
And rotating speed, totally 8~12d；
(5) it collects and expands the butter fruit stem cell that culture obtains, in -30 DEG C of pre-freeze 3h after 2h quick-frozen in liquid nitrogen, then thaw
30min, repeatedly 2 times after 20~30 DEG C place 10min, be then crushed to can cross 60 mesh sieve, by solid-liquid ratio be 1:4~6 add in
70~80% absolute ethyl alcohols, in 28~32 DEG C of stirring 8~12h of extraction, through strong Ultrasonic Pulverization cytoplasm, after the filtering of ultrasonic extraction liquid
Filtrate is collected, concentrates, be drying to obtain.
9. according to a kind of anti-aging beauty-care frost of claims 1 to 3 any one of them, which is characterized in that the eryngo general flavone
Preparation method be：It weighs eryngo and dry, pulverize 50~80 mesh sieve, be 1 by solid-liquid ratio:20~30 additions 70~80% are anhydrous
Ethyl alcohol carries out intermittent type microwave heating under 200~220W, and every 10~15s intervals are extracted 1 time, extract 60~70s altogether, filter,
And filter residue is washed with 70~90% absolute ethyl alcohols, merge all filtrate liquid in 70~90 DEG C of rotary evaporations, remove ethyl alcohol, freezing is dry
It is dry to obtain eryngo general flavone.
10. a kind of prepare such as a kind of method of anti-aging beauty-care frost of claim 1~9 any one of them, which is characterized in that packet
Include following steps：
A. tetra- sodium of EDTA, sodium pyrosulfite, butanediol, deionized water are mixed, obtains aqueous mixture；
B. again by butter fruit stem cell extract, eryngo general flavone, magnesium ascorbyl phosphate, Argireline, palmityl
Oligopeptides, palmityl tetrapeptide -3, tocopherol, Sodium Hyaluronate, xanthans each component after mixing, are added in into water phase, are carried out
Homogenization；
C. plant extracts, bi-imidazolidinyl urea, allantoin is sequentially added to stir evenly.
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| CN201810249683.2A CN108175741A (en) | 2018-03-23 | 2018-03-23 | A kind of anti-aging beauty-care frost and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619028A (en) * | 2018-06-30 | 2018-10-09 | 太原紫兰科技有限责任公司 | A kind of multiple-effect moisturizing daily renewal cream and preparation method thereof |
| WO2019243496A1 (en) * | 2018-06-20 | 2019-12-26 | Swiss Skin Power Ag | Skin formulation |
| CN111297760A (en) * | 2020-03-27 | 2020-06-19 | 广东梵蜜琳生物科技有限公司 | Composition with repairing effect and application thereof |
| CN112516004A (en) * | 2020-12-24 | 2021-03-19 | 美氏诗言(厦门)生物科技有限公司 | Formula of anti-aging skin care product |
-
2018
- 2018-03-23 CN CN201810249683.2A patent/CN108175741A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019243496A1 (en) * | 2018-06-20 | 2019-12-26 | Swiss Skin Power Ag | Skin formulation |
| CN108619028A (en) * | 2018-06-30 | 2018-10-09 | 太原紫兰科技有限责任公司 | A kind of multiple-effect moisturizing daily renewal cream and preparation method thereof |
| CN111297760A (en) * | 2020-03-27 | 2020-06-19 | 广东梵蜜琳生物科技有限公司 | Composition with repairing effect and application thereof |
| CN111297760B (en) * | 2020-03-27 | 2022-03-29 | 广东梵蜜琳生物科技有限公司 | Composition with repairing effect and application thereof |
| CN112516004A (en) * | 2020-12-24 | 2021-03-19 | 美氏诗言(厦门)生物科技有限公司 | Formula of anti-aging skin care product |
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Application publication date: 20180619 |