CN105748390A - Whitening and moisturizing mask and preparation method thereof - Google Patents

Whitening and moisturizing mask and preparation method thereof Download PDF

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Publication number
CN105748390A
CN105748390A CN201610134532.3A CN201610134532A CN105748390A CN 105748390 A CN105748390 A CN 105748390A CN 201610134532 A CN201610134532 A CN 201610134532A CN 105748390 A CN105748390 A CN 105748390A
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parts
donkey
soak
hide gelatin
aloe
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徐杰
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985Skin or skin outgrowth, e.g. hair, nails
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
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  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a whitening and moisturizing mask and a preparation method thereof.The whitening and moisturizing mask is composed of, by weight, 1-3 parts of Colla corii asini essence, 1-3 parts of hydrolyzed pearl, 50-60 parts of mineral water, 3-4 parts of butanediol, 1-2 parts of glycerol, 0.3-0.5 part of dipotassium glycyrrhizinate, 0.3-0.5 part of hyaluronic acid, 3-5 parts of Butyrspermum parkii fruit oil, 0.2-0.4 part of rosemary leaf extract, 0.5-1 part of Radix puerariae leaf, 0.1-0.3 part of peony root extract, 3-5 parts of chrysanthemum soaking liquid, 2-4 parts of aloe soaking liquid, 4-8 parts of almond, 3-7 parts of Radix asparagi, 2-4 parts of Poria cocos, 8-10 parts of Radix angelicae, 7-9 parts of Radix ampelopsis, 6-8 parts of common bletilla tuber, 3-5 parts of grape seed, 1-2 parts of lemongrass herb and 1-3 parts of Fructus gleditsiae.The whitening and moisturizing mask is safe and free of irritation, good in moisturizing effect and scientific in combining, can quickly control skin oil overflow, astringe pores, whiten skin and lock moisture of skin and effectively improve nutritional status, does not cause irritation, can promote skin metabolism, improve activity and antibacterial capability of skin, reduce pigmentation and prevent skin dryness to enable the skin to be soft, white and exquisite.

Description

A kind of whitening and moisturizing facial mask and preparation method thereof
Technical field
The present invention relates to a kind of facial mask, specifically a kind of whitening and moisturizing facial mask and preparation method thereof.
Background technology
Generally, use some treatment classes or the emulsifiable paste can beauty treatment skin so that it is object or aesthetic feeling condition are maintained at most preferably State, therefore occurs in that the mask product that can be used on skin, these mask product for face or health other Partial skin, mainly with skin whitening, remove wrinkle, prevent skin ageing and supplement and keep the moisture of skin to be Purpose, by it after skin surface keeps certain time, can be taken off by simple hand, but in facial mask very Many materials are not by percutaneous absorption, and assimilation effect is poor.
It addition, the facial mask on current Cosmetic Market all contains essence, preservative, bactericide.Consumer is growing After phase uses similar products, skin, it is possible that allergic reaction, even induces other diseases.Accordingly, it would be desirable to A kind of facial mask, not only has good using effect, and does not have side effect, without compromising on the body of consumer Body is healthy.
Summary of the invention
It is an object of the invention to provide a kind of can whitening go wrinkle, increase skin elasticity whitening and moisturizing facial mask and Its preparation method, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 1-3 part, hydrolyzed pearl 1-3 part, mineral water 50-60 part, butanediol 3-4 part, glycerine 1-2 part, dipotassium glycyrrhizinate 0.3-0.5 part, Hyaluronic acid 0.3-0.5 part, Butyrospermum parkii fruit oil 3-5 part, the Herba Pelargonii Graveolentis extract 0.2-0.4 part that changes, the root of kudzu vine carry Take thing 0.5-1 part, peony root extractive 0.1-0.3 part, chrysanthemum soak 3-5 part, aloe soak 2-4 part, Almond 4-8 part, lucid asparagus 3-7 part, Poria cocos 2-4 part, root of Dahurain angelica 8-10 part, radix ampelopsis 7-9 part, bletilla striata 6-8 Part, grape pip 3-5 part, lemongrass 1-2 part, Chinese honey locust 1-3 part.
As the further scheme of the present invention: described whitening and moisturizing facial mask, it is made up of the raw material of following weight portion: Donkey-hide gelatin purify 1.5-2.5 part, hydrolyzed pearl 1.5-2.5 part, mineral water 52-58 part, butanediol 3.2-3.8 part, Glycerine 1.2-1.8 part, dipotassium glycyrrhizinate 0.35-0.45 part, hyaluronic acid 0.35-0.45 part, Butyrospermum parkii fruit oil 3.5-4.5 part, the most repeatedly Herba Pelargonii Graveolentis extract 0.25-0.35 part, kudzu root extract 0.6-0.9 part, peony root extractive 0.15-0.25 part, chrysanthemum soak 3.5-4.5 part, aloe soak 2.5-3.5 part, almond 5-7 part, Tianmen Winter 4-6 part, Poria cocos 2.5-3.5 part, root of Dahurain angelica 8.5-9.5 part, radix ampelopsis 7.5-8.5 part, bletilla striata 6.5-7.5 part, Grape pip 3.5-4.5 part, lemongrass 1.2-1.8 part, Chinese honey locust 1.5-2.5 part.
As the present invention further scheme: described whitening and moisturizing facial mask, it is made up of the raw material of following weight portion: Donkey-hide gelatin purification 2 parts, hydrolyzed pearl 2 parts, mineral water 55 parts, butanediol 3.5 parts, glycerine 1.5 parts, Radix Glycyrrhizae Acid dipotassium 0.4 part, hyaluronic acid 0.4 part, Butyrospermum parkii really oil 4 parts, the most repeatedly Herba Pelargonii Graveolentis extract 0.3 part, Kudzu root extract 0.8 part, peony root extractive 0.2 part, chrysanthemum soak 4 parts, aloe soak 3 parts, 6 parts of almond, lucid asparagus 5 parts, 3 parts of Poria cocos, the root of Dahurain angelica 9 parts, radix ampelopsis 8 parts, the bletilla striata 7 parts, grape pip 4 Part, 1.5 parts of lemongrass, Chinese honey locust 2 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2-3h, and enzymolysis liquid prepares donkey-hide gelatin essence solution, warp through membrane filtration Being spray-dried prepared donkey-hide gelatin essence mixture standby, wherein, free amino acid mass fraction is 4%;
(3) take 30-50 part chrysanthemum and take flower, clean, in 20 times of weight deionized waters at being placed in 50-60 DEG C Soaking 40-44h, remove floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal under the conditions of 3000-4000r/min 8-12min, taking supernatant, to be filtrated to get chrysanthemum soak in 300 mesh sieve thin,tough silk standby;
(4) taking the fresh aloe of 20-40 part, the bulk of 1 cun of size is cut in clean peeling, is added by aloe fritter The deionized water of 10 times of weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 18-22h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 8-12min under the conditions of 3000-4000r/min, takes It is standby that supernatant is filtrated to get aloe soak in 300 mesh sieve thin,tough silk;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, the alcohol solution dipping 1-2h of the 85% of immersion 4-6 times amount, heating extraction 3-5h, reclaim ethanol, filter, Concentration is the thick paste of relative density 1.10-1.15 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter after being cooled to 20-30 DEG C Fruit tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by facial mask Paper is inserted in bag, and envelope obtains finished product.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is safe and non-stimulating, and replenishing water and preserving moisture is effective, scientific compatibility, can quickly control skin oil spilling, Convergence pore, skin whitening, the moisture content of pinning skin, be effectively improved nutrition condition, do not have excitant, promotes Skin metabolism, strengthens vigor and the antimicrbial power of skin, reduces pigmentation, prevent dry skin, make flesh Skin is soft, pure white, fine and smooth.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 1 part, hydrolyzed pearl 1 Part, mineral water 50 parts, butanediol 3 parts, glycerine 1 part, dipotassium glycyrrhizinate 0.3 part, hyaluronic acid 0.3 Part, Butyrospermum parkii fruit oil 3 parts, the Herba Pelargonii Graveolentis extract 0.2 part that changes, kudzu root extract 0.5 part, tree peony root carry Take thing 0.1 part, chrysanthemum soak 3 parts, aloe soak 2 parts, 4 parts of almond, lucid asparagus 3 parts, Poria cocos 2 parts, the root of Dahurain angelica 8 parts, radix ampelopsis 7 parts, the bletilla striata 6 parts, grape pip 3 parts, 1 part of lemongrass, Chinese honey locust 1 part.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2h, and enzymolysis liquid prepares donkey-hide gelatin essence solution through membrane filtration, through spray It is standby that mist is dried prepared donkey-hide gelatin essence mixture, and wherein, free amino acid mass fraction is 4%;
(3) take 30 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 50 DEG C are soaked 40h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 8-12min under the conditions of 3000r/min, takes supernatant It is filtrated to get chrysanthemum soak standby in 300 mesh sieve thin,tough silk;
(4) taking the fresh aloe of 20 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 18h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 8min under the conditions of 3000r/min, takes supernatant in 300 It is standby that mesh sieve thin,tough silk is filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, immerse 4 times amount 85% alcohol solution dipping 1h, heating extract 3h, reclaim ethanol, filter, dense It is condensed to the thick paste of relative density 1.10 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter fruit after being cooled to 20 DEG C Tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by face paper Inserting in bag, envelope obtains finished product.
Embodiment 2
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 1.5 parts, hydrolyzed pearl 1.5 parts, mineral water 52 parts, butanediol 3.2 parts, glycerine 1.2 parts, dipotassium glycyrrhizinate 0.35 part, hyalomitome Acid 0.35 part, Butyrospermum parkii fruit oil 3.5 parts, repeatedly repeatedly Herba Pelargonii Graveolentis extract 0.25 part, kudzu root extract 0.6 part, Peony root extractive 0.155 part, chrysanthemum soak 3.5 parts, aloe soak 2.5 parts, almond 5 part, day Door the winter 4 parts, 2.5 parts of Poria cocos, the root of Dahurain angelica 8.5 parts, radix ampelopsis 7.5 parts, the bletilla striata 6.5 parts, grape pip 3.5 parts, 1.2 parts of lemongrass, Chinese honey locust 1.5 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2.2h, and enzymolysis liquid prepares donkey-hide gelatin essence solution, warp through membrane filtration Being spray-dried prepared donkey-hide gelatin essence mixture standby, wherein, free amino acid mass fraction is 4%;
(3) take 35 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 52 DEG C are soaked 41h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 9min under the conditions of 3200r/min, take supernatant in It is standby that 300 mesh sieve thin,tough silk are filtrated to get chrysanthemum soak;
(4) taking the fresh aloe of 25 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 19h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 9min under the conditions of 3200r/min, takes supernatant in 300 It is standby that mesh sieve thin,tough silk is filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, immerse 4.5 times amount 85% alcohol solution dipping 1.2h, heating extract 3.5h, reclaim ethanol, filter, Concentration is the thick paste of relative density 1.11 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter fruit after being cooled to 22 DEG C Tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by face paper Inserting in bag, envelope obtains finished product.
Embodiment 3
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 2 parts, hydrolyzed pearl 2 Part, mineral water 55 parts, butanediol 3.5 parts, glycerine 1.5 parts, dipotassium glycyrrhizinate 0.4 part, hyaluronic acid 0.4 Part, Butyrospermum parkii fruit oil 4 parts, the Herba Pelargonii Graveolentis extract 0.3 part that changes, kudzu root extract 0.8 part, tree peony root carry Take thing 0.2 part, chrysanthemum soak 4 parts, aloe soak 3 parts, 6 parts of almond, lucid asparagus 5 parts, Poria cocos 3 parts, the root of Dahurain angelica 9 parts, radix ampelopsis 8 parts, the bletilla striata 7 parts, grape pip 4 parts, 1.5 parts of lemongrass, Chinese honey locust 2 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2.5h, and enzymolysis liquid prepares donkey-hide gelatin essence solution, warp through membrane filtration Being spray-dried prepared donkey-hide gelatin essence mixture standby, wherein, free amino acid mass fraction is 4%;
(3) take 40 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 55 DEG C are soaked 42h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 10min under the conditions of 3500r/min, takes supernatant It is filtrated to get chrysanthemum soak standby in 300 mesh sieve thin,tough silk;
(4) taking the fresh aloe of 30 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 20h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 10min under the conditions of 3500r/min, take supernatant in It is standby that 300 mesh sieve thin,tough silk are filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, immerse 5 times amount 85% alcohol solution dipping 1.5h, heating extract 4h, reclaim ethanol, filter, Concentration is the thick paste of relative density 1.12 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter fruit after being cooled to 25 DEG C Tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by face paper Inserting in bag, envelope obtains finished product.
Embodiment 4
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 2.5 parts, hydrolyzed pearl 2.5 parts, mineral water 58 parts, butanediol 3.8 parts, glycerine 1.8 parts, dipotassium glycyrrhizinate 0.45 part, hyalomitome Acid 0.45 part, Butyrospermum parkii fruit oil 4.5 parts, repeatedly repeatedly Herba Pelargonii Graveolentis extract 0.35 part, kudzu root extract 0.9 part, Peony root extractive 0.25 part, chrysanthemum soak 4.5 parts, aloe soak 3.5 parts, 7 parts of almond, Tianmen Winter 6 parts, 3.5 parts of Poria cocos, the root of Dahurain angelica 9.5 parts, radix ampelopsis 8.5 parts, the bletilla striata 7.5 parts, grape pip 4.5 parts, perfume 1.8 parts of thatch, Chinese honey locust 2.5 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2.8h, and enzymolysis liquid prepares donkey-hide gelatin essence solution, warp through membrane filtration Being spray-dried prepared donkey-hide gelatin essence mixture standby, wherein, free amino acid mass fraction is 4%;
(3) take 45 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 58 DEG C are soaked 43h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 11min under the conditions of 3800r/min, takes supernatant It is filtrated to get chrysanthemum soak standby in 300 mesh sieve thin,tough silk;
(4) taking the fresh aloe of 35 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 21h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 11min under the conditions of 3800r/min, take supernatant in It is standby that 300 mesh sieve thin,tough silk are filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, immerse 5.5 times amount 85% alcohol solution dipping 1.8h, heating extract 4.5h, reclaim ethanol, filter, Concentration is the thick paste of relative density 1.14 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter fruit after being cooled to 28 DEG C Tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by face paper Inserting in bag, envelope obtains finished product.
Embodiment 5
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 3 parts, hydrolyzed pearl 3 Part, mineral water 60 parts, butanediol 4 parts, glycerine 2 parts, dipotassium glycyrrhizinate 0.5 part, hyaluronic acid 0.5 Part, Butyrospermum parkii fruit oil 5 parts, the most repeatedly Herba Pelargonii Graveolentis extract 0.4 part, kudzu root extract 1 part, tree peony root extraction Thing 0.3 part, chrysanthemum soak 5 parts, aloe soak 4 parts, 8 parts of almond, lucid asparagus 7 parts, Poria cocos 4 Part, the root of Dahurain angelica 10 parts, radix ampelopsis 9 parts, the bletilla striata 8 parts, grape pip 5 parts, 2 parts of lemongrass, Chinese honey locust 3 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 3h, and enzymolysis liquid prepares donkey-hide gelatin essence solution through membrane filtration, through spray It is standby that mist is dried prepared donkey-hide gelatin essence mixture, and wherein, free amino acid mass fraction is 4%;
(3) take 50 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 60 DEG C are soaked 44h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 12min under the conditions of 4000r/min, takes supernatant It is filtrated to get chrysanthemum soak standby in 300 mesh sieve thin,tough silk;
(4) taking the fresh aloe of 40 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 22h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 12min under the conditions of 4000r/min, take supernatant in It is standby that 300 mesh sieve thin,tough silk are filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, immerse 6 times amount 85% alcohol solution dipping 2h, heating extract 5h, reclaim ethanol, filter, dense It is condensed to the thick paste of relative density 1.15 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter fruit after being cooled to 30 DEG C Tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by face paper Inserting in bag, envelope obtains finished product.
Comparative example 1
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 1.5 parts, hydrolyzed pearl 1.5 parts, mineral water 52 parts, butanediol 3.2 parts, glycerine 1.2 parts, dipotassium glycyrrhizinate 0.35 part, hyalomitome Acid 0.35 part, Butyrospermum parkii fruit oil 3.5 parts, repeatedly repeatedly Herba Pelargonii Graveolentis extract 0.25 part, kudzu root extract 0.6 part, Peony root extractive 0.155 part, chrysanthemum soak 3.5 parts, aloe soak 2.5 parts, almond 5 part, day Door the winter 4 parts, 2.5 parts of Poria cocos, the root of Dahurain angelica 8.5 parts, radix ampelopsis 7.5 parts, the bletilla striata 6.5 parts, grape pip 3.5 parts, Chinese honey locust 1.5 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2.2h, and enzymolysis liquid prepares donkey-hide gelatin essence solution, warp through membrane filtration Being spray-dried prepared donkey-hide gelatin essence mixture standby, wherein, free amino acid mass fraction is 4%;
(3) take 35 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 52 DEG C are soaked 41h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 9min under the conditions of 3200r/min, take supernatant in It is standby that 300 mesh sieve thin,tough silk are filtrated to get chrysanthemum soak;
(4) taking the fresh aloe of 25 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 19h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 9min under the conditions of 3200r/min, takes supernatant in 300 It is standby that mesh sieve thin,tough silk is filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, Chinese honey locust are cleaned, leaching Enter 4.5 times amount 85% alcohol solution dipping 1.2h, heating extract 3.5h, reclaim ethanol, filter, concentrate It is the thick paste of relative density 1.11 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract And peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, butter fruit after being cooled to 22 DEG C Tree fruit oil, hyaluronic acid are sufficiently stirred for, and prepare facial mask liquid;Facial mask liquid is carried out bag distribution packaging, so by face paper Inserting in bag, envelope obtains finished product.
Comparative example 2
A kind of whitening and moisturizing facial mask, is made up of the raw material of following weight portion: donkey-hide gelatin purifies 2.5 parts, hydrolyzed pearl 2.5 parts, mineral water 58 parts, butanediol 3.8 parts, glycerine 1.8 parts, dipotassium glycyrrhizinate 0.45 part, hyalomitome Acid 0.45 part, Butyrospermum parkii fruit oil 4.5 parts, repeatedly repeatedly Herba Pelargonii Graveolentis extract 0.35 part, kudzu root extract 0.9 part, Chrysanthemum soak 4.5 parts, aloe soak 3.5 parts, 7 parts of almond, lucid asparagus 6 parts, 3.5 parts of Poria cocos, The root of Dahurain angelica 9.5 parts, radix ampelopsis 8.5 parts, the bletilla striata 7.5 parts, grape pip 4.5 parts, 1.8 parts of lemongrass, Chinese honey locust 2.5 parts.
The preparation method of described whitening and moisturizing facial mask, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, by donkey-hide gelatin glue juice and compound protease The ratio that mass ratio is 100:1 add compound protease, wherein papain and dried meat ammonia in compound protease The mass ratio of pepsin is 2:1, enzymolysis 2.8h, and enzymolysis liquid prepares donkey-hide gelatin essence solution, warp through membrane filtration Being spray-dried prepared donkey-hide gelatin essence mixture standby, wherein, free amino acid mass fraction is 4%;
(3) take 45 parts of chrysanthemums and take flower, clean, the 20 times of weight deionized waters being placed at 58 DEG C are soaked 43h, Removing floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 11min under the conditions of 3800r/min, takes supernatant It is filtrated to get chrysanthemum soak standby in 300 mesh sieve thin,tough silk;
(4) taking the fresh aloe of 35 parts, the bulk of 1 cun of size is cut in clean peeling, adds 10 by aloe fritter The deionized water of times weight is squeezed the juice in juice extractor, and juice adds the deionized water of 1 times of weight again and soaks 21h, goes Except floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 11min under the conditions of 3800r/min, take supernatant in It is standby that 300 mesh sieve thin,tough silk are filtrated to get aloe soak;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust are washed Only, immerse 5.5 times amount 85% alcohol solution dipping 1.8h, heating extract 4.5h, reclaim ethanol, filter, Concentration is the thick paste of relative density 1.14 at 65 DEG C, standby;
(6) the donkey-hide gelatin essence solution that prepared step (2)-(5), chrysanthemum soak, aloe are soaked Liquid and medicinal extract all add to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract, Stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, Butyrospermum parkii fruit oil, hyaluronic acid after being cooled to 28 DEG C It is sufficiently stirred for, prepares facial mask liquid;Facial mask liquid carrying out bag distribution packaging, so inserts in bag by face paper, envelope obtains To finished product.
Embodiment 6
Whitening and moisturizing facial mask of the present invention is in the test of suppression cell B16 cell:
Murine B 16 Melanoma Cells has become the model system of quantitative assessment B16 cell.
The B16 cell taken the logarithm growth period, through 0.25% (percetage by weight) trypsinization, with RPMI-1640 It is 5 × 10 that complete medium is made into density5/ mL cell suspension, is inoculated in Tissue Culture Plate, be placed in 37 DEG C, 5% (percentage by volume) CO2Incubator in cultivate.
After adherent 24h, abandon nutrient solution, be separately added into embodiment 1, embodiment 2, comparative example 1 and comparative example 2 facial mask liquid prepared, control group adds isopyknic complete medium, continues to cultivate 48h.Survey respectively Determining intracellular melanin content, tyrosinase activity and reduced form paddy flesh sweet skin content, measurement result is shown in Table 1.
Table 1: whitening and moisturizing facial mask of the present invention is in the impact of suppression cell B16 cell
Project Melanin relative amount (%) TYR enzyme relative activity (%) Reduced glutathione relative amount (%)
Control group 100±3.4 100±5.4 3.4±0.1
Embodiment 1 36.7±3.2** 24.7±6.1** 101.5±0.8**
Embodiment 2 34.3±3.8** 25.4±5.8** 102.3±3.4**
Comparative example 1 54.8±2.1* 38.1±6.3* 78.6±0.8*
Comparative example 2 49.6±3.7* 40.2±5.5* 75.4±1.8*
* P < 0.05, compares variant with control group, * * P < 0.01, compares with control group and has significant difference.
As shown in Table 1, embodiment 1, embodiment 2, embodiment 3 all can reduce B16 cell melanin content, Suppression tyrosinase activity, raising reduced form paddy flesh sweet skin content, but embodiment 1 and the effect of embodiment 2 Than comparative example 1 and comparative example 2 better significantly, therefore between the composition of the present invention, there is Synergistic Effect, adds the efficient of whitening and moisturizing facial mask;Tyrosinase is the crucial rate-limiting enzyme of modulating melanin synthesis, The sweet skin of reduced form paddy skin is antioxidant important in organism, has risen important in suppression melanin synthesis process Effect, it is mainly combined by the action site of coloured glaze base and tyrosinase and suppresses the activity of tyrosinase.Above Analytic explanation, the anti-oxidant skin of collagen has the effect significantly inhibiting cell B16 cell, has whitening function.
The present invention is safe and non-stimulating, and replenishing water and preserving moisture is effective, scientific compatibility, can quickly control skin oil spilling, Convergence pore, skin whitening, the moisture content of pinning skin, be effectively improved nutrition condition, do not have excitant, promotes Skin metabolism, strengthens vigor and the antimicrbial power of skin, reduces pigmentation, prevent dry skin, make flesh Skin is soft, pure white, fine and smooth.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned enforcement Mode, in the ken that one skilled in the relevant art is possessed, it is also possible to without departing from this patent ancestor On the premise of purport, various changes can be made.

Claims (4)

1. a whitening and moisturizing facial mask, it is characterized in that, it is made up of the raw material of following weight portion: donkey-hide gelatin purifies 1-3 part, hydrolyzed pearl 1-3 part, mineral water 50-60 part, butanediol 3-4 part, glycerine 1-2 part, dipotassium glycyrrhizinate 0.3-0.5 part, hyaluronic acid 0.3-0.5 part, Butyrospermum parkii fruit oil 3-5 part, the most repeatedly Herba Pelargonii Graveolentis extract 0.2-0.4 part, kudzu root extract 0.5-1 part, peony root extractive 0.1-0.3 part, chrysanthemum soak 3-5 part, aloe soak 2-4 part, almond 4-8 part, lucid asparagus 3-7 part, Poria cocos 2-4 part, root of Dahurain angelica 8-10 part, radix ampelopsis 7-9 part, bletilla striata 6-8 part, grape pip 3-5 part, lemongrass 1-2 part, Chinese honey locust 1-3 part.
nullWhitening and moisturizing facial mask the most according to claim 1,It is characterized in that,It is made up of the raw material of following weight portion: donkey-hide gelatin purifies 1.5-2.5 part、Hydrolyzed pearl 1.5-2.5 part、Mineral water 52-58 part、Butanediol 3.2-3.8 part、Glycerine 1.2-1.8 part、Dipotassium glycyrrhizinate 0.35-0.45 part、Hyaluronic acid 0.35-0.45 part、Butyrospermum parkii fruit oil 3.5-4.5 part、The most repeatedly Herba Pelargonii Graveolentis extract 0.25-0.35 part、Kudzu root extract 0.6-0.9 part、Peony root extractive 0.15-0.25 part、Chrysanthemum soak 3.5-4.5 part、Aloe soak 2.5-3.5 part、Almond 5-7 part、Lucid asparagus 4-6 part、Poria cocos 2.5-3.5 part、Root of Dahurain angelica 8.5-9.5 part、Radix ampelopsis 7.5-8.5 part、Bletilla striata 6.5-7.5 part、Grape pip 3.5-4.5 part、Lemongrass 1.2-1.8 part、Chinese honey locust 1.5-2.5 part.
Whitening and moisturizing facial mask the most according to claim 1, it is characterized in that, it is made up of the raw material of following weight portion: donkey-hide gelatin purifies 2 parts, hydrolyzed pearl 2 parts, mineral water 55 parts, butanediol 3.5 parts, glycerine 1.5 parts, dipotassium glycyrrhizinate 0.4 part, hyaluronic acid 0.4 part, Butyrospermum parkii fruit oil 4 parts, the most repeatedly Herba Pelargonii Graveolentis extract 0.3 part, kudzu root extract 0.8 part, peony root extractive 0.2 part, chrysanthemum soak 4 parts, aloe soak 3 parts, 6 parts of almond, lucid asparagus 5 parts, 3 parts of Poria cocos, the root of Dahurain angelica 9 parts, radix ampelopsis 8 parts, the bletilla striata 7 parts, grape pip 4 parts, 1.5 parts of lemongrass, Chinese honey locust 2 parts.
4. the preparation method of the whitening and moisturizing facial mask as described in claim 1-3 is arbitrary, it is characterised in that specifically comprise the following steps that
(1) each raw material is weighed according to weight portion;
(2) taking the donkey-hide gelatin glue juice that mass concentration is 20% is enzymolysis raw material, compound protease is added in the ratio that mass ratio is 100:1 of donkey-hide gelatin glue juice with compound protease, wherein in compound protease, the mass ratio of papain and proline protein enzyme is 2:1, enzymolysis 2-3h, enzymolysis liquid prepares donkey-hide gelatin essence solution through membrane filtration, spray-dried prepared donkey-hide gelatin essence mixture is standby, and wherein, free amino acid mass fraction is 4%;
(3) take 30-50 part chrysanthemum and take flower, clean, 20 times of weight deionized waters at being placed in 50-60 DEG C are soaked 40-44h, remove floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 8-12min under the conditions of 3000-4000r/min, and taking supernatant, to be filtrated to get chrysanthemum soak in 300 mesh sieve thin,tough silk standby;
(4) the fresh aloe of 20-40 part is taken, the bulk of 1 cun of size is cut in clean peeling, the deionized water that aloe fritter adds 10 times of weight is squeezed the juice in juice extractor, juice adds the deionized water of 1 times of weight again and soaks 18-22h, remove floating foreign material, 200 mesh silk cover filterings, filtrate is centrifugal 8-12min under the conditions of 3000-4000r/min, and taking supernatant, to be filtrated to get aloe soak in 300 mesh sieve thin,tough silk standby;
(5) almond, lucid asparagus, Poria cocos, the root of Dahurain angelica, radix ampelopsis, the bletilla striata, grape pip, lemongrass, Chinese honey locust being cleaned, the alcohol solution dipping 1-2h of the 85% of immersion 4-6 times amount, 3-5h is extracted in heating, reclaim ethanol, filtering, concentration is the thick paste of relative density 1.10-1.15 at 65 DEG C, standby;
(6) donkey-hide gelatin essence solution, chrysanthemum soak, aloe soak and medicinal extract that step (2)-(5) prepare all are added to mineral water, add hydrolyzed pearl, the most repeatedly Herba Pelargonii Graveolentis extract, kudzu root extract and peony root extractive, stirring adds butanediol, glycerine, dipotassium glycyrrhizinate, Butyrospermum parkii really oil, hyaluronic acid and is sufficiently stirred for after being cooled to 20-30 DEG C, prepare facial mask liquid;Facial mask liquid carrying out bag distribution packaging, so inserts in bag by face paper, envelope obtains finished product.
CN201610134532.3A 2016-03-10 2016-03-10 Whitening and moisturizing mask and preparation method thereof Pending CN105748390A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107334701A (en) * 2017-07-14 2017-11-10 德兴市宋氏葛业有限公司 A kind of root of kudzu vine facial mask and preparation method thereof
CN108042429A (en) * 2017-12-29 2018-05-18 河南洛阳红牡丹产业研发有限公司 The facial mask and preparation method of a kind of seed peel containing tree peony
CN111603429A (en) * 2020-06-06 2020-09-01 程定义 Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof
CN112842963A (en) * 2021-03-02 2021-05-28 上海浩泰生物科技有限公司 Saponin extract and preparation method and application thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107334701A (en) * 2017-07-14 2017-11-10 德兴市宋氏葛业有限公司 A kind of root of kudzu vine facial mask and preparation method thereof
CN108042429A (en) * 2017-12-29 2018-05-18 河南洛阳红牡丹产业研发有限公司 The facial mask and preparation method of a kind of seed peel containing tree peony
CN111603429A (en) * 2020-06-06 2020-09-01 程定义 Traditional Chinese medicine skin care lotion with whitening and freckle removing effects and preparation method thereof
CN112842963A (en) * 2021-03-02 2021-05-28 上海浩泰生物科技有限公司 Saponin extract and preparation method and application thereof
CN112842963B (en) * 2021-03-02 2023-03-28 上海浩泰生物科技有限公司 Saponin extract and preparation method and application thereof

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