CN108355046A - A kind of massage cream of the trace element containing Khotan jade and preparation method thereof - Google Patents
A kind of massage cream of the trace element containing Khotan jade and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Abstract
The invention discloses a kind of massage creams of the trace element containing Khotan jade and preparation method thereof; by the way that Chinese medicine cortex albiziae, fructus choerospondiatis, common nightblooming cereus, fritillary bulb, Morinda officinalis, Chinese yam, ultra micro Khotan jade powder are carried out reasonable compatibility; the massage cream of the trace element containing Khotan jade is made after scientific matching; with the promoting flow of qi and blood circulation; resolving stagnation for tranquilization; the effect of clearing heat and moistening lung, Kidney-invigorating and tendon-reinforcing bone.The massage cream of present invention trace element containing Khotan jade have it is natural mild, the characteristics of having no toxic side effect, long-time service can effective clearing away the lungheat and moisturizing, calm the nerves, kidney is supported in enriching yin.
Description
Technical field
The present invention relates to a kind of massage cream, the massage cream and preparation method thereof of especially a kind of trace element containing Khotan jade.
Background technology
With rapid development of economy, the living environment severe exacerbation of the mankind, while rhythm of life are accelerated, the drink of people
Food, living habit and the various pressure in live and work, make the body of people be chronically at the state of over fatigue, easily evil
Gas cut body, yin-fluid loss, cloudy sun not processed, water fire not processed, flaring up of deficient fire lead to insomnia and dreamful sleep, have the fidgets, while kidney and lung
Disease incidence is also increasing.
Kidney is supported in enriching yin on the market at present, is calmed the nerves, most of drug of moistening lung is the Oral administration based on extract oral
Destruction there are the first pass effect of liver and enteron aisle to drug makes the absorptivity of drug reduce, and the course for the treatment of is long, and has side effect.And
Middle the effective elements of the medicine is penetrated into human body by acupuncture point and has the function that maintenance by externally used paste percutaneous dosing, and external application is massaged
Cream have many advantages, such as it is easy to use, safe, have no toxic side effect.It is clear that patent of invention CN201510439367.8 discloses a kind of yin-nourishing
Lung moisturizes Chinese medicine composition of relieving sore-throat and its preparation method and application.The active constituent of the Chinese medicine composition is by following weight
Part raw material is prepared:44-52 parts of great burdock achene, 15-20 parts of reed root, 10-15 parts of Chinese olive, 8-16 parts of glutinous rehmannia are Radix Ophiopogonis 8-16 part, yellow
8-16 parts of a kind of reed mentioned in ancient books, 5-13 parts of moutan bark, 11-19 parts of radix paeoniae rubra, 5-13 parts of campanulaceae, 11-29 parts of radix scrophulariae, 8-16 parts of the stem of noble dendrobium, chrysanthemum 8-16
Part, 8-16 parts of peppermint, 11-16 parts of cordate houttuynia, 10-15 parts of the root bark of white mulberry, 2-10 parts of Radix Glycyrrhizae, using Chinese medicine composition and matrix or load
Massage cream made of body, it is mild to skin it is non-stimulated, have no toxic side effect, have the effect of comprehensive clearing lung-heat.The invention formula components are numerous
It is miscellaneous, and effect is single, can not meet consumer demand.
Invention content
Based on this, the purpose of the present invention is to provide a kind of massage cream of the trace element containing Khotan jade and preparation method thereof,
Specific technical solution is as follows:
A kind of massage cream of the trace element containing Khotan jade, includes the ingredient of following mass percent:
Cortex albiziae 1-3%, fructus choerospondiatis 1-3%, common nightblooming cereus 0.5-2.5%, fritillary bulb 0.5-2.5%, Morinda officinalis 1-3%, Chinese yam
2-6%, ultra micro Khotan jade powder 1-5%.
Preferably, the massage cream of the trace element containing Khotan jade, includes the ingredient of following mass percent:Cortex albiziae
1.5-2.5%, fructus choerospondiatis 1.5-2.5%, common nightblooming cereus 1-2%, fritillary bulb 1-2%, Morinda officinalis 1.5-2.5%, Chinese yam 3-5%, ultra micro
Khotan jade powder 2-4%.
Preferably, the massage cream of the trace element containing Khotan jade, includes the ingredient of following mass percent:Cortex albiziae
2%, fructus choerospondiatis 2%, common nightblooming cereus 1.5%, fritillary bulb 1.5%, Morinda officinalis 2%, Chinese yam 4%, ultra micro Khotan jade powder 3%.
Wherein, the preparation method of the ultra micro Khotan jade powder includes the following steps:
(1) it by Khotan jade particle, cleans, removal wherein impurity, low temperature drying;
(2) vibromill is added in the Khotan jade after removal of impurities and is ground into ultra-micro powder, grain size is less than 10 μm;
(3) gained powder being subjected to high temperature sintering 10min, temperature is at 600-800 DEG C, to remove mercury and arsenic therein, drop
Temperature is up to ultra micro Khotan jade powder.
The massage cream of the trace element of the present invention containing Khotan jade further includes the ingredient of following mass percent:Glycerine
The smooth stearate 1- of 2-10%, dormant oil 10-20%, ethylhexyl palmitate 10-20%, cetostearyl alcohol 0.5-2.5%, sorb
3%, carbomer 0.1-0.3%, triethanolamine 0.1-0.3%, methyl hydroxybenzoate 0.1-0.5%, Nipasol 0.1-0.5%, go
Ion water surplus.
The preparation method of the massage cream of the trace element of the present invention containing Khotan jade, includes the following steps:
(1) cortex albiziae, fructus choerospondiatis, common nightblooming cereus, fritillary bulb, Morinda officinalis and Chinese yam are cleaned into drying respectively, are crushed into powder, cross 80-
120 mesh sieve, spare;
(2) glycerine, carbomer, deionized water are mixed and is added in water phase pot, opened stirring and be warming up to 80-85 DEG C, heat preservation
10-30min;
(3) by dormant oil, ethylhexyl palmitate, cetostearyl alcohol, the smooth stearate of sorb, methyl hydroxybenzoate, Nipasol
Mixing is added in oil phase pot, opens stirring and is warming up to 80-85 DEG C, keeps the temperature 10-30min;
(4) mixing speed of emulsification pot is maintained at 50-80r/min, by the mixing of the mixture of step (2) and step (3)
Object sequentially adds in emulsification pot, homogeneous 10-30min;
(5) by triethanolamine be added emulsification pot in, stir evenly, 40-45 DEG C to be cooled to, be added ultra micro Khotan jade powder and
The herb powder of step (1) stirs evenly the massage cream to get the trace element containing Khotan jade.
The effect of each ingredient of the present invention, is described below:
Cortex albiziae:It is mild-natured, it is sweet in flavor.Thoughts of returning home warp, Liver Channel, lung channel.Have effects that resolving stagnation for tranquilization, activating blood circulation and reducing swelling.With controlling the heart
Refreshing uneasy, melancholy insomnia, lung carbuncle sore swells, traumatic injury.
Fructus choerospondiatis:It is mild-natured, it is sweet in flavor, sour.Have effects that the promoting flow of qi and blood circulation, nourishing heart, tranquilizing the mind.With control qi depression to blood stasis, the obstruction of qi in the chest is had a pain,
It is palpitation, confused and worried.
Common nightblooming cereus:Cold nature, it is sweet in flavor.It is distributed in lung channel.Have effects that clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.With controlling lung heat or the dryness of the lung, void
Impairment and cough, convulsive seizure due to phlegm-fire scrofula.
Fritillary bulb:Cold nature, it is bitter, sweet.Distributed in lung channel, the heart channel of Hang-Shaoyin.With clearing heat and moistening lung, the effect of preventing phlegm from forming and stopping coughing.With controlling lung
Hot cough caused by dryness, dry cough lack phlegm, deficiency of yin and overstrain cough, cough sputum streaked with blood.
Morinda officinalis:Slightly warm in nature, it is sweet in flavor, pungent.Return kidney channel, Liver Channel.With kidney-replenishing, the effect of strengthening the bones and muscles, wind-damp dispelling.With controlling
Impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscles and bones impotence.
Chinese yam:It is mild-natured, it is sweet in flavor.Converge to the spleen channel, lung channel, kidney channel.Have effects that tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.
With control spleen eating less, endless diarrhea, the deficiency syndrome of the lung breath with cough, under emission due to the kidney deficiency, band, frequent micturition, abnormal heat quench one's thirst.
Khotan jade:One of Chinese four big name jade, main component SiO2, MgO, CaO and a small amount of FeO, have and promote blood
Bad, enhancing metabolism, exclusion skin toxins are followed, radiation is kept out, and repairs skin damage cell and enhances cell viability
Effect.
Compared with prior art, the present invention has the advantages that:
(1) Chinese medicine cortex albiziae, fructus choerospondiatis, common nightblooming cereus, fritillary bulb, Morinda officinalis, Chinese yam are carried out reasonable compatibility by the present invention, and science is matched
The massage cream of the trace element containing Khotan jade is made than after, with the promoting flow of qi and blood circulation, resolving stagnation for tranquilization, clearing heat and moistening lung, Kidney-invigorating and tendon-reinforcing bone
Effect can generate synergistic function between mentioned component, substantially increase the present invention and calm the nerves and support lung kidney function effect.
(2) present invention also added ultra micro Khotan jade powder, by promoting local blood circulation, drug effect be promoted to absorb.
(3) product of the present invention has natural mild, the characteristics of having no toxic side effect, long-time service can effective clearing away the lungheat and moisturizing,
Calm the nerves, kidney is supported in enriching yin.
Specific implementation mode
Below in conjunction with specific embodiment, the present invention is further elaborated.
The all the components title occurred in text is INCI (International Nomenclature Cosmetic
Ingredient), i.e. international cosmetic raw material name institute is to defined title.
The formula of the embodiment 1-5 of the massage cream of present invention trace element containing Khotan jade, is shown in Table 1.
Table 1
The preparation method of the massage cream of above-described embodiment 1-5 trace elements containing Khotan jade includes the following steps:
(1) cortex albiziae, fructus choerospondiatis, common nightblooming cereus, fritillary bulb, Morinda officinalis and Chinese yam are cleaned into drying respectively, are crushed into powder, cross 80-
120 mesh sieve, spare;
(2) glycerine, carbomer, deionized water are mixed and is added in water phase pot, opened stirring and be warming up to 80-85 DEG C, heat preservation
10-30min;
(3) by dormant oil, ethylhexyl palmitate, cetostearyl alcohol, the smooth stearate of sorb, methyl hydroxybenzoate, Nipasol
Mixing is added in oil phase pot, opens stirring and is warming up to 80-85 DEG C, keeps the temperature 10-30min;
(4) mixing speed of emulsification pot is maintained at 50-80r/min, by the mixing of the mixture of step (2) and step (3)
Object sequentially adds in emulsification pot, homogeneous 10-30min;
(5) by triethanolamine be added emulsification pot in, stir evenly, 40-45 DEG C to be cooled to, be added ultra micro Khotan jade powder and
The herb powder of step (1) stirs evenly the massage cream to get the trace element containing Khotan jade.
Embodiment 6
Mouse skin irritant test
(1) test specimen:The massage cream of the trace element containing Khotan jade made from embodiment 1;
(2) test method:With reference to (cosmetics health specification) 2007 Ministry of Public Health's health legal system and supervision department;
(3) experimental animal:Small white mouse;
(4) test result:7 days Skin Irritation Tests use the massage cream of the trace element containing Khotan jade of 1 gained of embodiment
Have no stimulate the reaction.Illustrate that the massage cream of the trace element of the invention containing Khotan jade is nonirritant, it is safe.
Embodiment 7
Clinical test
Clinical effect trial is carried out to the massage cream of the embodiment 1-5 trace elements containing Khotan jade prepared.
One, subject enrollment standard:
(1) unlimited 120 people of men and women is randomly divided into 6 groups, cooperation product beta test requirement;
(2) irritated insomnia, dry cough lack cough or without phlegm, soreness and weakness of waist and knees;
(3) the good compatibility test of energy, good daily life system time and eating habit can be kept in the trial employment period.
Two, given the test agent, sample application method and time
Test group:
Given the test agent:The massage cream of the trace element containing Khotan jade prepared by embodiment 1-5, while commercially available declaring have with a
Have to calm the nerves and supports the massage cream that lung kidney function is imitated as control group;
Application method:It takes given the test agent to massage in right amount and is applied to Shen Shu point, fei shu cave and neighbouring position;
Usage time:Two weeks, daily in the morning, afternoon and evening each 1 time.
Three, evaluation of clinical curative effect standard
Irritated insomnia, soreness and weakness of waist and knees, cough disappear for recovery from illness;Irritated insomnia, soreness and weakness of waist and knees, substantially reduced cough is aobvious
Effect;Irritated insomnia, soreness and weakness of waist and knees, unchanged cough is invalid.Concrete outcome is shown in Table 2.
Table 2
It is on probation by 2 weeks by a definite date it can be seen from test data in table 2, embodiment 1-5 trace elements containing Khotan jade
Massage cream effective percentage has reached 80% or more, and commercially available group of effective percentage is only 50%, illustrates the present invention containing Khotan jade trace element
Massage cream can effectively carry out clearing away the lungheat and moisturizing, calm the nerves, enriching yin supports kidney, and effect is good more than existing commercial product.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.
Claims (6)
1. a kind of massage cream of the trace element containing Khotan jade, which is characterized in that include the ingredient of following mass percent:Cortex albiziae
1-3%, fructus choerospondiatis 1-3%, common nightblooming cereus 0.5-2.5%, fritillary bulb 0.5-2.5%, Morinda officinalis 1-3%, Chinese yam 2-6%, ultra micro and field
Beautiful powder 1-5%.
2. the massage cream of the trace element containing Khotan jade as described in claim 1, which is characterized in that including following mass percent
Ingredient:Cortex albiziae 1.5-2.5%, fructus choerospondiatis 1.5-2.5%, common nightblooming cereus 1-2%, fritillary bulb 1-2%, Morinda officinalis 1.5-2.5%, mountain
Medicine 3-5%, ultra micro Khotan jade powder 2-4%.
3. the massage cream of the trace element containing Khotan jade as claimed in claim 2, which is characterized in that including following mass percent
Ingredient:Cortex albiziae 2%, fructus choerospondiatis 2%, common nightblooming cereus 1.5%, fritillary bulb 1.5%, Morinda officinalis 2%, Chinese yam 4%, ultra micro Khotan jade powder
3%.
4. the massage cream of the trace element as described in any one of claims 1-3 containing Khotan jade, which is characterized in that further include following
The ingredient of mass percent:Glycerine 2-10%, dormant oil 10-20%, ethylhexyl palmitate 10-20%, cetostearyl alcohol 0.5-
2.5%, the smooth stearate 1-3% of sorb, carbomer 0.1-0.3%, triethanolamine 0.1-0.3%, methyl hydroxybenzoate 0.1-
0.5%, Nipasol 0.1-0.5%, deionized water surplus.
5. the massage cream of the trace element as described in any one of claims 1-3 containing Khotan jade, which is characterized in that the ultra micro and
The preparation method of field jade powder includes the following steps:
(1) it by Khotan jade particle, cleans, removal wherein impurity, low temperature drying;
(2) vibromill is added in the Khotan jade after removal of impurities and is ground into ultra-micro powder, grain size is less than 10 μm;
(3) gained powder is subjected to high temperature sintering 10min, temperature is at 600-800 DEG C, and to remove mercury and arsenic therein, cooling is
Obtain ultra micro Khotan jade powder.
6. a kind of preparation method for the massage cream preparing the trace element according to any one of claims 1-4 containing Khotan jade,
It is characterized in that, includes the following steps:
(1) cortex albiziae, fructus choerospondiatis, common nightblooming cereus, fritillary bulb, Morinda officinalis and Chinese yam are cleaned into drying respectively, are crushed into powder, cross 80-120 mesh
Sieve, it is spare;
(2) glycerine, carbomer, deionized water are mixed and is added in water phase pot, opened stirring and be warming up to 80-85 DEG C, keep the temperature 10-
30min;
(3) dormant oil, ethylhexyl palmitate, cetostearyl alcohol, the smooth stearate of sorb, methyl hydroxybenzoate, Nipasol are mixed
It is added in oil phase pot, opens stirring and be warming up to 80-85 DEG C, keep the temperature 10-30min;
(4) mixing speed of emulsification pot is maintained at 50-80r/min, by the mixture of step (2) and the mixture of step (3) according to
In secondary addition emulsification pot, homogeneous 10-30min;
(5) triethanolamine is added in emulsification pot, is stirred evenly, 40-45 DEG C to be cooled to, ultra micro Khotan jade powder and step is added
(1) herb powder stirs the massage cream to get the trace element containing Khotan jade.
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CN112316042A (en) * | 2020-03-25 | 2021-02-05 | 杭州秀美涵康生物科技有限公司 | Muscle-relaxing tendon-stretching massage cream containing ultramicro far-infrared ceramic powder and preparation method thereof |
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Application publication date: 20180803 |