CN108096146A - With whitening and anti-aging, the rose enzyme of anti-inflammatory effect and its application in cosmetics - Google Patents
With whitening and anti-aging, the rose enzyme of anti-inflammatory effect and its application in cosmetics Download PDFInfo
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- CN108096146A CN108096146A CN201810040546.8A CN201810040546A CN108096146A CN 108096146 A CN108096146 A CN 108096146A CN 201810040546 A CN201810040546 A CN 201810040546A CN 108096146 A CN108096146 A CN 108096146A
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- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 238000005360 mashing Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 239000011858 nanopowder Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229930007790 rose oxide Natural products 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037331 wrinkle reduction Effects 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
There is whitening and anti-aging, the rose enzyme of anti-inflammatory effect and its application in cosmetics the invention discloses a kind of.The present invention ensures orientation fermentation using temperature controlled fermentation process, and nutriment and active ingredient in rose is made fully to be discharged, and solable matter is completely dissolved, and prepared rose enzyme has exact skin whitening, anti-aging and anti-inflammatory and other effects.The present invention further by prepared rose enzyme and has the function of that the plant extracts of skin whitening, anti-aging or anti-inflammatory effect carries out compounding to have developed having effects that more preferably skin whitening, anti-aging, anti-inflammatory cosmetics, these cosmetics can be the preparation of the routine such as lotion, facial mask or face cream.
Description
Technical field
The present invention relates to rose enzyme more particularly to whitening and anti-aging, the rose enzyme of anti-inflammatory effect and its extraction
Method, the invention further relates to the rose enzyme answering in the cosmetics with whitening and anti-aging or anti-inflammatory effect are prepared
With the preparation for belonging to rose enzyme and its application field in cosmetics.
Background technology
Rose (scientific name：Rosa rugosa Thunb.) original producton location China.Belong to Rosales, rose family machaka, branch bar
Spininess pierces, imparipinnate leaf, leaflet 5-9 pieces, and ellipse has side thorn.Petal obovate, polyphyll to half polyphyll, flower have purplish red
Color, white, the fruiting period 8-9 months, oblate spheroid.The more weak soft vertical and how close thorn of branch.Rose can be used as industrial crops, flower master
It is used for food and refines essence attar of rose, attar of rose is applied to the industry such as cosmetics, food, fine chemistry industry.Yunnan black tea polyphyll is red
Rose is a kind of rose variety of Yunnan native country plantation, wherein using the rose variety of Anning area plantation to be best, is
Unique " Yunnan black tea polyphyll " eats red rose, has the spies such as growth potential is strong, the florescence is long, pattern is gorgeous, fragrance is dense, processing quality is good
Point, available for food, cosmetics even depth exploitation kind, research shows that natural Yunnan black tea Rosa Damascana is most important natural
One of fragrance source and the important source material of production modern industry Rosa Damascana and various skin care item.The essential oil group of natural rose
Into sufficiently complex, main component is monoterpenes compound, such as rose oxide, citronellol, geraniol, linalool, sesquiterpene and again
Hemiterpene etc., serial (C17~C27) amounts of accounting for of other paraffins are very big, wherein geraniol, citronellol, nerol and they
Esters constitute the basis of Rose Essentielle and the main aroma ingredient of rose, be that one kind needs to be integrated deep development
One of plant.
Facial mask is a kind of to integrate cleaning, skin care, nutrition, beauty, wrinkle resistant, anti-ageing multipurpose cosmetics.Its work
With being coated on skin of face, after drying after a while, one layer of membranoid substance is formed on the skin, film is taken off or washed off
Afterwards, enhancing skin of face nutrition is can reach, enhances skin metabolism, nutrition face Skin Cell enhances cell viability.Strongly
Mite of going out is sterilized, toxic removing toxin expelling removes scurf, dirt, softens horny layer of epidermis, moisturizing, tender skin, wrinkle resistant anti-decrepit beauty maintain green grass or young crops
Spring glamour.
104546653 A of Chinese invention patent CN (a kind of shin moisturizer containing rose enzyme of denomination of invention) disclose one
Shin moisturizer and preparation method of the kind containing rose enzyme, the shin moisturizer include rose enzyme, vinegar, glycerine, propylene glycol；Pass through fresh rose
Rare flower cleans and crush mashing, obtains slurries, adds in fruits and vegetables and Chinese herbal medicine mixing；It adds water to react with cellulose enzyme powder and decompose, warp
Saccharomycetes to make fermentation filters off slagging-off, obtains rose enzyme；Vinegar, glycerine, propylene glycol are added in into rose enzyme again, is stirred evenly
Sealing, 25-30 DEG C is protected from light standing 7 days, obtains shin moisturizer；The invention provides one kind to be not added with any preservative ingredient, to skin
Skin does not stimulate, and the shin moisturizer containing rose enzyme of whitening anti-aging is played to skin, has certain market development prospect.
It is advised in rose enzyme production technology used in the patent document, with ferment branch of existing Chinese biological fermentation industry association
Fixed plant enzyme fermentation standard technology is not inconsistent, and is not the ferment production technology of standard；And since it is in rose fermentation process
The traditional Chinese medicine ingredients added can destroy the Flavoring Components of rose and the endemic element procyanidine of rose.
103932942 A (denominations of invention of Chinese invention CN：Ferment facial mask) a kind of ferment facial mask is disclosed, it is in belonging to
Medicine cosmetics ferment facial mask production technical field removes ferment facial mask, brevicaude pit viper gall spirulina powdery ferment face including the soft shape of zeolite
Film, big bryozoatum paste ferment facial mask, snake oil shaping ferment facial mask, medical stone clay ferment facial mask, gourd, fruit and vegetable extract ferment
Plain nano powder composition.Ingredient used in facial mask is only described in the patent document, so-called ferment ingredient production process is simultaneously
It does not describe, thus it is speculated that simply borrowed ferment concept, the function of cosmetics demand is difficult actually to be verified.
In addition, technical solution in above patent document ferment effectiveness itself, the other active ingredients of cooperation research and
Using upper, corresponding compounding was not done, biological function is not also verified accordingly.
It is therefore it provides a kind of with exact whitening and anti-aging, the rose enzyme of anti-inflammatory effect and by itself and others
Plant extracts is compounded to be obviously improved its whitening and anti-aging, anti-inflammatory effect, this for develop new cosmetic product with
And it widens market application and has great importance.
The content of the invention
An object of the present invention is to provide a kind of with exact whitening and anti-aging, the rose enzyme of anti-inflammatory effect；
The second object of the present invention is to provide the rose with exact whitening and anti-aging, anti-inflammatory effect described in a kind of prepare
The method of rare ferment；
The third object of the present invention is to be compounded to obtain effect by the rose enzyme and other plant extracts
More preferably there is the composition of whitening and anti-aging or anti-inflammatory effect；
The above-mentioned purpose of the present invention is achieved through the following technical solutions：
A kind of rose enzyme is prepared by the following method to obtain：
(1) suitable yeast, sugar and lemon tablet are added in after roseleaf is mixed with water, control temperature is at 20~35 DEG C
Under the conditions of ferment；
(2) after tunning separation of solid and liquid, added in into filtrate acetobacter or acetobacter and probiotic group into it is mixed
Object is closed to be carried out in 10~40 DEG C without alcoholization temperature controlled fermentation；Either after tunning separation of solid and liquid, added in into filtrate by acetic acid
Bacillus and probiotic group into mixture in 10~40 DEG C carry out without alcoholization temperature controlled fermentation；
(3) tunning filtration sterilization to get.
In order to reach better effect, counted according to kg/L, the solid-liquid ratio of roseleaf and water may be controlled in step (1)
1:(3-20) is preferably 1:(5-15), more preferably 1:(5-10).
Fermentation time described in step (1) can flexibly be slapped according to the process and temperature condition and other factors of fermentation
Control, can be for example 5-20 days, be preferably 7-15 days.
As for the dosage of yeast, sugar and the lemon tablet added in step (1), those skilled in the art can be according to fermentation raw material
The factors such as dosage and the condition of fermentation (for example temperature) flexibly determine that the number of dosage is little for the influential effect of fermentation.
Probiotics described in step (2) include lactobacillus class (such as lactobacillus acidophilus, Lactobacillus casei, Lactobacillus Jensenii,
Raman lactobacillus etc.), Bifidobacterium class (such as bifidobacterium longum, bifidobacterium breve, avette Bifidobacterium, bifidobacterium thermophilum
Deng), any one or more than one in gram-positive cocci class (such as streptococcus fecalis, galactococcus, intermediary streptococcus) press
According to the mixture of arbitrary proportion composition.Strain used can be commercially available by various commercial sources in the present invention, such as can
To pass through Chinese industrial Microbiological Culture Collection administrative center (CICC) or China General Microbiological culture presevation administration committee
Common micro-organisms center (CGMCC) is commercially available, and the strain being commercially available by commercial channel can be suitably used for the present invention.
Step (2) medium ethanol content can terminate to ferment when being zero, and rose enzyme is obtained after heat sterilization.
The solid-liquid separating method in step (2) include centrifugation, using micro-filtrate membrane filtration, using ultrafiltration membrance filter, adopt
With nanofiltration membrane or being applied in combination using any one or more of reverse osmosis membrane filtration.
Rose of the present invention can be the rose for originating from any kind Anywhere, preferably originate from Gao Hai
It rises sheer from level ground the rose in area, such as the rose of Yunnan Province, especially originates in the Yunnan black tea polyphyll red rose of 1500 meters of height above sea level or more；Yunnan black tea weight
Valve red rose is a kind of rose variety of Yunnan native country plantation, wherein using the rose variety of Anning area plantation to be best,
It is that unique " Yunnan black tea polyphyll " eats red rose, has growth potential is strong, the florescence is long, pattern is gorgeous, fragrance is dense, processing quality is good etc.
Feature.
The present invention is beneficial to the maximum protection of rose procyanidine bioplasm, control using controllable fermentation process
Warm fermentation process can ensure orientation fermentation, nutriment and active ingredient in rose be made fully to be discharged, soluble object
Matter is completely dissolved；Rose enzyme is prepared in dark red or pink liquid using the method for the present invention, pH3.0, mainly effectively into
Divide and its content is：Procyanidin content is 10~54 μ g/L, 1~5g/L of acetic acid, 1~8g/L of lactic acid, 1~5g/L of citric acid.
Skin-whitening application effect experiments have shown that, rose enzyme provided by the present invention have promotion infiltration, improve skin skin
Color highlights the effect of the skin colour of skin, is embodied as making the colour of skin uniform, and gloss is promoted, and removal is obscure, and color spot is thin out.By the present invention
Rose enzyme be prepared into the anti-aging of facial mask experiments have shown that, rose enzyme have exact anti-aging effect, applied to skin
After show as wrinkle reduction, skin bullet profit, smooth water profit.The anti-inflammatory experiment table for the facial mask that rose enzyme of the present invention is prepared into
It is bright, the facial mask have it is apparent it is antipruritic, releive, anti-inflammatory the effects that, skin, protection skin barrier can be takeed good care of very well.Effectively drop
Low, sensitive skin of releiving, user's flush, itch etc. caused by inflammatory stimulus situations such as significantly improve.
Therefore, the rose enzyme prepared by the present invention have it is anti-oxidant, diminish inflammation and suppress growth of microorganism etc. a variety of
Effect can further be prepared into functional cosmetics.
The present invention is further developed with prepared rose enzyme including anti-senescence function, whitening and anti-inflammatory (antiallergic
Sense) function cosmetics, rose ferment and whitening, anti-oxidant, anti-saccharification and anti-inflammatory isoreactivity ingredient are compounded, Jin Erkai
The ferment cosmetic product of range of functional is sent, these cosmetics make use of the Biological Attribute of Industrial of this rose enzyme, wherein
Mainly add anti-oxidant and activity of fighting against senium ingredient by adding rose enzyme in terms of anti-senescence function, for each target of anti-aging
Point works (elite+frost)；In whitening function, inhibited using rose enzyme and compound addition for tyrosinase, melanin
The comprehensive addition (creams) such as corpusculum migration, Endothelin antagonism；In anti-inflammatory function, then rose enzyme coordinates corresponding anti-inflammatory plant
Extract reaches its biological function (facial mask+breast)
There is the composition of whitening and skin-protecting the present invention provides a kind of, including the rose enzyme prepared by the present invention and
Acceptable auxiliary material or carrier；
The present invention by prepared rose enzyme and known each Plant Extracts with white-skinned face function, including：It is high
(edelweiss is composite family to mountain HUORONGCAO extract, the plant of Leontopodium.It is called and does the thin snow grass of high mountain, edelweiss is called and does
The thin snow grass of high mountain, edelweiss, edelweiss etc.；It is documented that there are clearing heat and cooling blood, anti-inflammatory diuresis, remove the works such as Urine proteins and blood urine
With), glycyrrhiza glabra root extract, purslane extract, aloe extract, blueberry extract, ginkgo biloba extract, white willow bark carry
Object, Folium Rhododendri Simsii extract, Flos persicae extract etc. are taken, carries out compounding experiment, it is expected therefrom to screen the tool for obtaining and there is cooperative effect
There is the composition of optimal beauty whitening efficacy；Experimental result finds that the rose enzyme prepared by the present invention is carried with edelweiss
Take object that there is most preferably synergistic, the two is compatible to have effects that optimal whitening and softening skin afterwards together.
Further, there is the composition of whitening and skin-protecting the present invention provides a kind of, including：It is safe and a effective amount of
Rose enzyme, edelweiss extract and acceptable carrier or auxiliary material；
The present invention also provides a kind of skin care compositions with senile-resistant efficacy, including the rose ferment prepared by the present invention
Plain and acceptable auxiliary material or carrier；Wherein, can also include safety in said composition and a effective amount of edelweiss extract,
Glycyrrhiza glabra root extract, purslane extract, aloe extract, blueberry extract, ginkgo biloba extract, the extraction of white willow bark
Object, Folium Rhododendri Simsii extract, Flos persicae extract etc. have the plant extracts of senile-resistant efficacy.
Invention further provides a kind of skin care compositions with anti-inflammatory efficacy, including the rose prepared by the present invention
Ferment and acceptable auxiliary material or carrier；Wherein, can also safety be included and the extraction of a effective amount of edelweiss in said composition
Object, glycyrrhiza glabra root extract, purslane extract, aloe extract, blueberry extract, ginkgo biloba extract, white willow bark carry
Take object, Folium Rhododendri Simsii extract, Flos persicae extract etc. that there is the plant extracts of anti-inflammatory efficacy.
Wherein, the carrier or auxiliary material are that those skilled in the art easily determine according to the knowledge or skills grasped,
For example, the carrier or auxiliary material can be continuous oil phase and discontinuous water phase；Such as can be that silicone oil, non-silicone oil are organic
The ingredients such as oil, wetting agent, solubilizer, auxiliary acid, polyol ester, softening agent；Specifically, the carrier or auxiliary material include but unlimited
In：Butanediol, allantoin, xanthans, citric acid, sodium citrate, propylene glycol, Sodium Hyaluronate, methyl hydroxybenzoate, Chlorphenesin,
Stereth -2, stereth -21, cetostearyl alcohol, stearine/PEG-100 stearines, octanoic acid/
Triglyceride DDD, saualane, tocopherol, acryloyldimethyl Taurine ammonium/VP copolymers, isononyl isononanoate, benzene oxygen second
Alcohol, bisabolol and dipotassium glycyrrhizinate.
Heretofore described " safe and effective amount " refers to significantly causing positive improvement under conditions of use
Effect, but the amount is again less high to prevent improperly side effect (such as apparent skin irritatin or allergy), this belongs to this
Within the normal determination range of field personnel.
Description of the drawings
The process flow chart of Fig. 1 the method for the present invention.
Specific embodiment
Further describe the present invention below in conjunction with specific embodiment, the advantages and features of the present invention will be with description and
It is apparent.But these embodiments are only exemplary, do not form any restrictions to the scope of the present invention.People in the art
Member it should be understood that without departing from the spirit and scope of the invention can to the present invention details and form modify or
It replaces, but these modifications and replacement are each fallen in protection scope of the present invention.
The preparation of 1 rose enzyme of embodiment
Roseleaf is cleaned, by solid-liquid ratio 1：5 (kg/L) meters are mixed with water, add in suitable yeast, sugar, lemon tablet,
It controlled at 30 DEG C, ferments 7 days, after aerogenesis, filtrate is collected by centrifugation, obtained filtrate is added in by acetobacter and thermophilic
The mixture of Lactobacillus lactis composition carries out, without alcoholization temperature controlled fermentation, when ethanol content is zero, obtaining after heat sterilization in 40 DEG C
Rose enzyme.
By detection, contain 54 μ g/L rose procyanidine, the acetic acid of 4g/L, the breast of 8g/L in prepared rose enzyme
Acid, the citric acid of 5g/L.
The preparation of 2 rose enzyme of embodiment
Roseleaf is cleaned, by solid-liquid ratio 1：7 (kg/L) are mixed with water, add in suitable yeast, sugar, lemon tablet, control
Temperature processed is 20 DEG C, ferments 15 days, after aerogenesis, filtrate is collected by centrifugation, and obtained filtrate is added in acetobacter in 30 DEG C
It carries out, without alcoholization temperature controlled fermentation, when ethanol content is zero, rose enzyme being obtained after heat sterilization.
By detection, contain 40 μ g/L rose procyanidine, the acetic acid of 3g/L, the breast of 6g/L in prepared rose enzyme
Acid, the citric acid of 4g/L.
The preparation of 3 rose enzyme of embodiment
Roseleaf is cleaned, by solid-liquid ratio 1：10 (kg/L) are mixed with water, add in suitable yeast, sugar, lemon tablet, control
Temperature processed is 35 DEG C, ferments 7 days, after aerogenesis, filtrate is collected by centrifugation, and obtained filtrate is added in by acetobacter and milk-globule
The mixture of bacterium composition carries out, without alcoholization temperature controlled fermentation, when ethanol content is zero, rose ferment being obtained after heat sterilization in 12 DEG C
Element.
By detection, contain 38 μ g/L rose procyanidine, the acetic acid of 3g/L, the breast of 6g/L in prepared rose enzyme
Acid, the citric acid of 4g/L.
The preparation of 4 rose enzyme of embodiment
Roseleaf is cleaned, by solid-liquid ratio 1：5 (kg/L) are mixed with water, add in suitable yeast, sugar, lemon tablet, control
Temperature processed is 30 DEG C, ferments 10 days, after aerogenesis, filtrate is collected by centrifugation, and obtained filtrate is added in by acetobacter and breast
The mixture of coccus composition carries out, without alcoholization temperature controlled fermentation, when ethanol content is zero, rose being obtained after heat sterilization in 10 DEG C
Ferment.
By detection, containing 30 μ g/L rose procyanidine in prepared rose enzyme, the acetic acid of 3g/L, 65g/L's
Lactic acid, the citric acid of 4g/L.
The preparation of the anti-ageing frost of 5 rose enzyme of embodiment
First, each raw material is weighed according to following dosage
A phases:
Carbomer：0.2-0.4 parts
Butanediol：3-8 parts
Allantoin：0.05-0.2 parts
Xanthans：0.05-0.2 parts
Propylene glycol：3-8 parts
Sodium Hyaluronate:0.01-0.15 parts
Methyl hydroxybenzoate：0.1-0.2 parts
Chlorphenesin：0.05-0.15 parts
Citric acid：0.02-0.3 parts
Sodium citrate：0.1-1 parts
Deionized water：29.8-67.07 parts；
B phases:
Stereth -2：1.5-2.5 part
Stereth -21：1.5-2.5 part
Cetostearyl alcohol：1-2 parts
Stearine/PEG-100 stearines：1.5-2.5 part
Caprylic/capric triglyceride：5-8 parts
Dimethyl silicone polymer：3-5 parts
Isononyl isononanoate：4-6 parts
Tocopherol：0.3-1 parts
C phases:
Phenoxyethanol：0.2-0.4 parts
Bisabolol：0.1-0.5 parts
Dipotassium glycyrrhizinate：0.05-0.3 parts
Triethanolamine：0.2-0.4 parts
Rose enzyme prepared by embodiment 1：7-15 parts
- 1 copper of tripeptides：1-3 parts
Dipeptides diaminobutyryl benzyl amide diacetin：0-2.5 parts；
2nd, preparation method
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, heat preservation 5-10 minutes after dissolving completely；
2. B phases are put into oil phase pot, stirring is warming up to 78-83 DEG C, heat preservation 5-10 minutes after dissolving completely；
3. B phase materials are pumped into main cooker under stirring, stir 3 minutes and add in C phase dispersant liquids, homogeneous 3-5 minutes, heat preservation is stirred
It mixes 5 minutes, cools down；
4. being cooled to 42 DEG C, D phase materials are sequentially added, stirring 10 minutes is uniform to material.
A kind of preparation of 6 rose enzyme anti-inflammatory facial mask of embodiment
First, each raw material is weighed according to following consumption proportion
A phases:
Deionized water：61.77-82.79 parts
Glycerine：5-10 parts
Allantoin：0.05-0.2 parts
Xanthans：0.05-0.3 parts
Hydroxyethyl cellulose：0.05-0.3 parts
Propylene glycol：5-10 parts
Sodium Hyaluronate:0.01-0.3 parts
Methyl hydroxybenzoate：0.15 part
Chlorphenesin：0.08 part
B phases:
Phenoxyethanol：0.3 part
Panthenol：0.3-1.0 parts
Citric acid：0.02-0.3 parts
Dipotassium glycyrrhizinate：0.05-0.3 parts
Sodium citrate：0.1-1 parts
Rose enzyme prepared by embodiment 3：5-10 parts；
2nd, preparation method：
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, cooling after dissolving completely；
2. being cooled to 40-42 DEG C, B phase raw materials are put into, are stirred evenly.
The preparation of 7 rose enzyme whitening emulsion of embodiment
First, each raw material is weighed according to following percentage dosage：
A phases:
Deionized water：27.3-64.47 parts
Butanediol：3-8 parts
Allantoin：0.05-0.2 parts
Xanthans：0.05-0.2 parts
Citric acid：0.02-0.3 parts
Sodium citrate：0.1-1 parts
Propylene glycol：3-8 parts
Sodium Hyaluronate:0.01-0.15 parts
Methyl hydroxybenzoate：0.1-0.2 parts
Chlorphenesin：0.05-0.15 parts
B phases:
Stereth -2：1.5-2.5 part
Stereth -21：1.5-2.5 part
Cetostearyl alcohol：1.5-2.5 part
Stearine/PEG-100 stearines：1.5-2.5 part
Caprylic/capric triglyceride：5-8 parts
Saualane：3-7 parts
Tocopherol：0.3-1 parts
C phases:
Acryloyldimethyl Taurine ammonium/VP copolymers：0.3-1.3 parts
Isononyl isononanoate：4-6 parts
D phases:
Phenoxyethanol：0.2-0.4 parts
Bisabolol：0.1-0.5 parts
Dipotassium glycyrrhizinate：0.05-0.3 parts
Rose enzyme prepared by embodiment 3：10-20 parts；
2nd, preparation method
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, heat preservation 5-10 minutes after dissolving completely；
2. B phases are put into oil phase pot, stirring is warming up to 78-83 DEG C, heat preservation 5-10 minutes after dissolving completely；
3. B phase materials are pumped into main cooker under stirring, stir 3 minutes and add in C phase dispersant liquids, homogeneous 3-5 minutes, heat preservation is stirred
It mixes 5 minutes, cools down；
4. being cooled to 42 DEG C, D phase materials are sequentially added, stirring 10 minutes is uniform to material；
5. physical and chemical index discharges after the assay was approved.
The preparation one of anti-ageing frost of the comparative example 1 without rose enzyme weighs each raw material according to following dosage
A phases:
Deionized water：61.72 parts
Carbomer：0.3 part
Butanediol：6 parts
Allantoin：0.1 part
Xanthans：0.12 part
Propylene glycol：4 parts
Sodium Hyaluronate:0.1 part
Methyl hydroxybenzoate：0.15 part
Chlorphenesin：0.08 part
Citric acid：0.03 part
Sodium citrate：0.5 part
B phases:
Stereth -2：1.8 part
Stereth -21：2 parts
Cetostearyl alcohol：1.5 part
Stearine/PEG-100 stearines：1.8 part
Caprylic/capric triglyceride：6 parts
Dimethyl silicone polymer：3 parts
Isononyl isononanoate：5 parts
Tocopherol：0.8 part
C phases:
Phenoxyethanol：0.3 part
Bisabolol：0.2 part
Dipotassium glycyrrhizinate：0.2 part
Triethanolamine：0.3 part
- 1 copper of tripeptides：2 parts
Dipeptides diaminobutyryl benzyl amide diacetin：2 parts；
2nd, preparation method
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, heat preservation 5-10 minutes after dissolving completely；
2. B phases are put into oil phase pot, stirring is warming up to 78-83 DEG C, heat preservation 5-10 minutes after dissolving completely；
3. B phase materials are pumped into main cooker under stirring, stir 3 minutes and add in C phase dispersant liquids, homogeneous 3-5 minutes, heat preservation is stirred
It mixes 5 minutes, cools down；
4. being cooled to 42 DEG C, D phase materials are sequentially added, stirring 10 minutes is uniform to material.
Application effect experiment of the rose enzyme in whitening and skin-protecting prepared by 1 present invention of test example
First, test method
1st, experiment grouping
Experiment is divided into 19 groups, 19 groups of test groups (add respectively different have effects that the plant extracts of whitening and skin-protecting)；
The plant extracts difference that 19 groups of test groups are added is as follows：
Test group (1)：Rose enzyme；
Test group (2)：Edelweiss (LEONTOPODIUM ALPINUM) extract；
Test group (3)：Glycyrrhiza glabra root extract；
Test group (4)：Purslane extract；
Test group (5)：Aloe extract；
Test group (6)：Blueberry extract；
Test group (7)：Ginkgo biloba extract；
Test group (8)：White willow bark extract；
Test group (9)：Folium Rhododendri Simsii extract；
Test group (10)：Flos persicae extract；
Test group (11)：Rose enzyme and edelweiss extract；
Test group (12)：Rose enzyme and glycyrrhiza glabra root extract；
Test group (13)：Rose enzyme and purslane extract；
Test group (14)：Rose enzyme and aloe extract；
Test group (15)：Rose enzyme and blueberry extract；
Test group (16)：Rose enzyme and ginkgo biloba extract；
Test group (17)：Rose enzyme and white willow bark extract；
Test group (18)：Rose enzyme and Folium Rhododendri Simsii extract；
Test group (19):Rose enzyme and Flos persicae extract.
Edelweiss (leontopodium alpinum) extract, glycyrrhiza glabra root extract, purslane extract,
Aloe extract, blueberry extract, ginkgo biloba extract, white willow bark extract, Folium Rhododendri Simsii extract are normal according to this field
The extracting method of rule is prepared；These extracting methods disclose in the literature, and those skilled in the art also can be normal according to what is grasped
These plant extracts are prepared in rule technical ability extraction；In addition, these above-mentioned plant extracts can be bought by commercial sources
It obtains.
2nd, the preparation of test sample (lotion)
(1) preparation of blank control sample lotion：
Each component is weighed according to following dosage：
A phases：
Deionized water：61.86 parts
Butanediol：6 parts
Allantoin：0.15 part
Xanthans：0.1 part
Citric acid：0.03 part
Sodium citrate：0.5 part
Propylene glycol：5 parts
Sodium Hyaluronate:0.13 part
Methyl hydroxybenzoate：0.15 part
Chlorphenesin：0.08 part
B phases:
Stereth -2：1.8 part
Stereth -21：2.0 part
Cetostearyl alcohol：1.8 part
Stearine/PEG-100 stearines：1.7 part
Caprylic/capric triglyceride：7 parts
Saualane：5 parts
Tocopherol：0.7 part
C phases:
Acryloyldimethyl Taurine ammonium/VP copolymers：0.4 part
Isononyl isononanoate：5 parts
D phases:
Phenoxyethanol：0.15 part
Bisabolol：0.3 part
Dipotassium glycyrrhizinate：0.15 part；
Its preparation method comprises the following steps：
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, heat preservation 5-10 minutes after dissolving completely；
2. B phases are put into oil phase pot, stirring is warming up to 78-83 DEG C, heat preservation 5-10 minutes after dissolving completely；
3. B phase materials are pumped into main cooker under stirring, stir 3 minutes and add in C phase dispersant liquids, homogeneous 3-5 minutes, heat preservation is stirred
It mixes 5 minutes, cools down；
4. being cooled to 42 DEG C, D phase materials are sequentially added, stirring 10 minutes is uniform to material；
5. physical and chemical index discharges after the assay was approved.
(2) each sample of test group prepare it is as follows：
The preparation of test group (1) sample emulsion：
A phases:
Deionized water：59.86 parts
Butanediol：6 parts
Allantoin：0.15 part
Xanthans：0.1 part
Citric acid：0.03 part
Sodium citrate：0.5 part
Propylene glycol：5 parts
Sodium Hyaluronate:0.13 part
Methyl hydroxybenzoate：0.15 part
Chlorphenesin：0.08 part；
B phases:
Stereth -2：1.8 part
Stereth -21：2.0 part
Cetostearyl alcohol：1.8 part
Stearine/PEG-100 stearines：1.7 part
Caprylic/capric triglyceride：7 parts
Saualane：5 parts
Tocopherol：0.7 part；
C phases:
Acryloyldimethyl Taurine ammonium/VP copolymers：0.4 part
Isononyl isononanoate：5 parts
D phases:
Phenoxyethanol：0.15 part
Bisabolol：0.3 part
Dipotassium glycyrrhizinate：0.15 part；
Rose enzyme：2 parts；
Its preparation method comprises the following steps：
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, heat preservation 5-10 minutes after dissolving completely；
2. B phases are put into oil phase pot, stirring is warming up to 78-83 DEG C, heat preservation 5-10 minutes after dissolving completely；
3. B phase materials are pumped into main cooker under stirring, stir 3 minutes and add in C phase dispersant liquids, homogeneous 3-5 minutes, heat preservation is stirred
It mixes 5 minutes, cools down；
4. being cooled to 42 DEG C, D phase materials are sequentially added, stirring 10 minutes is uniform to material；
5. physical and chemical index discharges after the assay was approved.
Respectively by test group (1) test sample D phases in the preparation process of the test sample of test group (2)-test group (10)
In rose enzyme replace with respectively edelweiss extract, glycyrrhiza glabra root extract, purslane extract, aloe extraction
Object, blueberry extract, ginkgo biloba extract, white willow bark extract, Folium Rhododendri Simsii extract, Flos persicae extract；Remaining component with
And the preparation of completely same test group (1) sample of preparation method.
The preparation of the test sample lotion of test group (11)：
A phases:
Deionized water：57.86 parts
Butanediol：6 parts
Allantoin：0.15 part
Xanthans：0.1 part
Citric acid：0.03 part
Sodium citrate：0.5 part
Propylene glycol：5 parts
Sodium Hyaluronate:0.13 part
Methyl hydroxybenzoate：0.15 part
Chlorphenesin：0.08 part
B phases:
Stereth -2：1.8 part
Stereth -21：2.0 part
Cetostearyl alcohol：1.8 part
Stearine/PEG-100 stearines：1.7 part
Caprylic/capric triglyceride：7 parts
Saualane：5 parts
Tocopherol：0.7 part
C phases:
Acryloyldimethyl Taurine ammonium/VP copolymers：0.4 part
Isononyl isononanoate：5 parts
D phases:
Phenoxyethanol：0.15 part
Bisabolol：0.3 part
Dipotassium glycyrrhizinate：0.15 part
Rose enzyme：2 parts
Edelweiss extract：2 parts；
Its preparation method comprises the following steps：
1. by A it is congenial enter main cooker in after, stirring is warming up to 80-85 DEG C, heat preservation 5-10 minutes after dissolving completely；
2. B phases are put into oil phase pot, stirring is warming up to 78-83 DEG C, heat preservation 5-10 minutes after dissolving completely；
3. B phase materials are pumped into main cooker under stirring, stir 3 minutes and add in C phase dispersant liquids, homogeneous 3-5 minutes, heat preservation is stirred
It mixes 5 minutes, cools down；
4. being cooled to 42 DEG C, D phase materials are sequentially added, stirring 10 minutes is uniform to material；
5. physical and chemical index discharges after the assay was approved.
Respectively by test group (11) test sample D in the preparation process of the test sample of test group (12)-test group (19)
Edelweiss extract in phase each replaces with glycyrrhiza glabra root extract, purslane extract, aloe extract, blueberry
Extract, ginkgo biloba extract, white willow bark extract, Folium Rhododendri Simsii extract, Flos persicae extract；Remaining component and preparation side
The preparation of completely same test group (11) sample of method.
3rd, test method
Test method：Double blinding, random, control test are selected, volunteer 342 is chosen, every group 18, uses above-mentioned preparation
Test sample (1)-(19) (lotion) carry out regional correlation test, for observing single whitening effect.Use front and rear comparison
Method is using artificial observation, and with 0-10 points of scoring mechanism record observation as a result, 5 points is do not change, as score value raises, score value is cured
Height, for skin whitening effect better.
Application method：Right face blank testing control sample, left face test test sample (1)-(19), each use sooner or later in one day
Once, terminated using 30 days.
4th, test result
Test result is shown in Table 1.
1 test sample of table (1)-(19) (lotion) carries out whitening and skin-protecting effect test result
According to result of the test as it can be seen that the rose enzyme prepared by the present invention is imitated for skin with exact whitening and skin-protecting
Fruit；By rose enzyme difference edelweiss extract, glycyrrhiza glabra root extract, purslane extract, aloe extract, indigo plant
Certain kind of berries extract, ginkgo biloba extract, white willow bark extract, Folium Rhododendri Simsii extract and Flos persicae extract are found only after being compounded
There is the compounding of rose enzyme and edelweiss extract that there is significant synergy, and rose enzyme is planted with other
Object extract (glycyrrhiza glabra root extract, purslane extract, aloe extract, blueberry extract, ginkgo biloba extract, white willow
Bark extract, Folium Rhododendri Simsii extract, Flos persicae extract) compounded combination the equal unobvious of cooperative effect.
The application effect experiment of rose enzyme anti aging effect prepared by 2 present invention of test example
First, test method
Test method：Selection double blinding, random, control test, choose volunteer 20, and wherein each 10 of men and women, which uses, implements
Anti-ageing white selection area prepared by example 4 carries out contrast test, observes single anti-ageing effect.People is used using front and rear control methods
For observation, with 0-10 points of scoring mechanism record observation as a result, 5 points is do not change, score value is higher, and anti-aging effects are better.
Application method：1. (without rose enzyme, remaining ingredient and preparation method are the same as implementation for number formula for the test of right eye angle
Example 4), 2. number formula (the anti-ageing frost of rose enzyme prepared by embodiment 4) is tested at left eye angle, is used once within one day, uses tie within 30 days
Beam.
2nd, result of the test
Anti-ageing measure of merit marking the results are shown in Table 2.
2 anti-ageing measure of merit of table marking result
It is visible according to test result：Left eye angle skin aging is alleviated compared with right eye angle clearly, shows as wrinkle and substantially subtracts
It is few, skin bullet profit, smooth water profit, it was demonstrated that rose enzyme prepared by the present invention has exact senile-resistant efficacy.
The application effect experiment of rose enzyme anti-inflammatory prepared by 3 present invention of test example
First, test method
Test method：Double blinding, random, control test are selected, chooses sensitive skin volunteer 20, wherein each 10 of men and women
Half face of anti-inflammatory facial mask prepared using embodiment 5 carries out contrast test, observes single anti-inflammatory and releives effect.Using front and rear
Control methods is using artificial observation, and with 0-10 points of scoring mechanism record observation as a result, 5 points is do not change, score value is higher, anti-inflammatory
Effect is better.
Application method：1. a number formula (is free of rose enzyme, remaining ingredient and the same embodiment of preparation method for right face test
5), left face tests 2. number formula (rose enzyme anti-inflammatory facial mask prepared by embodiment 5), and it is repeated every second day, cleans flesh
Face mask film 15 minutes or so again after skin use 15 i.e. one month to terminate.
2nd, result of the test
The marking of anti-inflammatory measure of merit the results are shown in Table 3：
3 anti-inflammatory measure of merit of table marking result
The anti-inflammatory facial mask that test result shows to be prepared with rose enzyme of the present invention has significant antipruritic, anti-inflammatory etc.
Effect.
Claims (10)
1. a kind of have whitening and anti-aging, the rose enzyme of anti-inflammatory efficacy, which is characterized in that its preparation method includes：
(1) suitable yeast, sugar and lemon tablet, condition of the control temperature at 20~35 DEG C are added in after roseleaf is mixed with water
Lower fermentation；
(2) after tunning separation of solid and liquid, acetobacter is added in into filtrate and is carried out at 10~40 DEG C without alcoholization temperature controlled fermentation；Or
After person is tunning separation of solid and liquid, added in into filtrate by acetobacter and probiotic group into mixture 10~40 DEG C into
Row is without alcoholization temperature controlled fermentation；
(3) tunning filtration sterilization to get.
2. rose enzyme described in accordance with the claim 1, it is characterised in that：It is counted according to kg/L, roseleaf and water in step (1)
Solid-liquid ratio control for 1:(3-20) is preferably 1:(5-15), more preferably 1:(5-10)；During fermentation described in step (1)
Between be 5-20 days, be preferably 7-15 days.
3. rose enzyme described in accordance with the claim 1, it is characterised in that：The probiotics includes lactobacillus class, bifid bar
The mixture that any one or more than one in mushroom or gram-positive cocci class are formed according to arbitrary proportion.
4. rose enzyme described in accordance with the claim 1, it is characterised in that：The solid-liquid separating method in step (2) includes
Any one or more of centrifugation, microfiltration membranes, ultrafiltration membrane, NF membrane or reverse osmosis membrane are applied in combination.
5. according to the rose enzyme described in claim 1-4 any one, it is characterised in that：The rose enzyme is in dark red or powder
Red liquid, pH3.0；Its principle active component and its content are：Procyanidine 10~54 μ g/L, 1~5g/L of acetic acid, lactic acid 1
~8g/L, 1~5g/L of citric acid.
6. a kind of have effects that the skin care compositions of whitening and skin-protecting, including：The claim 1-4 any one of safe and effective amount
Rose enzyme and acceptable auxiliary material or carrier.
7. a kind of skin care compositions with senile-resistant efficacy, including：The rose of the claim 1-4 any one of safe and effective amount
Rare ferment and acceptable auxiliary material or carrier.
8. a kind of have effects that the skin care compositions of anti-inflammatory, including：The rose of the claim 1-4 any one of safe and effective amount
Rare ferment and acceptable auxiliary material or carrier.
9. according to the skin care compositions described in claim 6-8 any one, it is characterised in that：Also containing safe and effective amount
Edelweiss extract, glycyrrhiza glabra root extract or purslane extract.
10. according to the skin care compositions described in claim 6-8 any one, it is characterised in that：It is prepared into lotion, face cream
Or facial mask.
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| CN110638738A (en) * | 2019-11-22 | 2020-01-03 | 上海黛莲娜化妆品有限公司 | Method for preparing ecological nutrient solution by treating roses in low-temperature bath and application |
| CN115607485A (en) * | 2022-06-28 | 2023-01-17 | 银谷芳香科技有限公司 | Preparation method and application of pearl oyster shell powder and rose composite fermentation liquor |
| CN117050923A (en) * | 2023-10-13 | 2023-11-14 | 山东福瑞达生物股份有限公司 | Lactobacillus rhamnosus LR06 and application thereof in fermentation of chenopodium album |
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| CN117050923A (en) * | 2023-10-13 | 2023-11-14 | 山东福瑞达生物股份有限公司 | Lactobacillus rhamnosus LR06 and application thereof in fermentation of chenopodium album |
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