CN113143817A - Jerusalem artichoke acne-removing composition and application thereof - Google Patents
Jerusalem artichoke acne-removing composition and application thereof Download PDFInfo
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Abstract
The invention discloses a jerusalem artichoke acne-removing composition which comprises a jerusalem artichoke extract, a mogrosia macrantha leaf extract and a centella asiatica extract, wherein the mass ratio of the jerusalem artichoke extract to the mogrosia macrantha leaf extract is (10-15): (1-5): (1-3). The jerusalem artichoke extract comprises a jerusalem artichoke leaf extract and a jerusalem artichoke tuber extract, and the mass ratio of the jerusalem artichoke leaf extract to the jerusalem artichoke tuber extract is (4-12): (1-3). The jerusalem artichoke leaf extract is obtained by drying, crushing and sieving jerusalem artichoke leaves and extracting by a reflux extraction method; the jerusalem artichoke tuber extract is prepared by cleaning and peeling fresh jerusalem artichoke tubers, slicing, blanching with hot water, and drying to obtain dry jerusalem artichoke slices; pulverizing dried Jerusalem artichoke slices to obtain Jerusalem artichoke dry powder, dissolving in water, performing microwave treatment, adding water, extracting to obtain extractive solution, and rotary evaporating the extractive solution. The acne-removing composition disclosed by the invention is good in effect, quick in effect, safe and free of side effect, and can be prepared into facial cleanser, conditioning water, essence, facial mask and the like for use in various forms.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a jerusalem artichoke acne removing composition and application thereof.
Background
Acne, also known as whelk, is a long-term skin disorder that occurs when the hair follicles are blocked by dead skin cells and oil from the skin. Propionibacterium acnes (Propionibacterium acnes) are slow-growing (usually facultative anaerobic) gram-positive bacteria associated with the skin condition of acne. This bacterium is largely commensal and is part of the skin flora present on the skin of most healthy adults. Propionibacterium acnes live deep in hair follicles and pores, far from the skin surface. In these hair follicles, the propionibacterium acnes use sebum, cellular debris and metabolic byproducts from the surrounding skin tissue as their primary source of energy and nutrients. Increased sebum production by sebaceous gland hyperactivity (sebaceous gland hyperplasia), or blockage of hair follicles, can lead to the growth and proliferation of propionibacterium acnes bacteria. The medicinal treatment for acne mainly comprises alpha hydroxy acid, antiandrogen, antibiotic, and anti-seborrhea medicine, and has effects of resisting inflammation, regulating hormone, killing Propionibacterium acnes, and normalizing skin cell exfoliation and sebum production in pores, so as to prevent obstruction. However, the drug treatment is easy to generate side effects, the drug is taken orally or externally for treatment, the burden of the liver and the kidney is increased through the metabolism of the liver and the kidney, and the relapse is easy to occur after the drug is stopped. The plant-derived acne removal product is safe and effective and is more and more accepted by people.
Jerusalem artichoke (Helianthus tuberosus L), also known as Dioscorea zingiberensis, Jerusalem artichoke, and Coprinus comatus, is a perennial herb of Helianthus of Compositae, originally produced in North America, introduced into Europe in the seventeen century, and then introduced into China. In recent years, researches show that tubers of jerusalem artichoke contain abundant inulin, protein, ash, crude fiber and the like, leaves of jerusalem artichoke contain considerable phenolic acid compounds besides abundant flavonoid compounds, and the bioactive function of the jerusalem artichoke is very obvious. The jerusalem artichoke tubers and jerusalem artichoke leaves have the effects of clearing heat, cooling blood and reducing swelling in traditional Chinese medicine. Inulin in Jerusalem artichoke tuber can be used for treating diabetes, and phenolic acid compounds in Jerusalem artichoke leaf are also used for inhibiting plant fungi. The jerusalem artichoke is rich in amino acid, sugar, vitamins and mineral substances and also contains a plurality of enzymes, so that the jerusalem artichoke tubers and jerusalem artichoke leaves have wide application, but the application of the jerusalem artichoke in acne removing products is not reported.
Disclosure of Invention
Aiming at the prior art, the invention aims to provide a jerusalem artichoke acne-removing composition and application thereof. The acne-removing composition disclosed by the invention is good in effect, safe, free of side effects, and capable of being prepared into facial cleanser, conditioning water, essence, facial mask and the like for use in various forms.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a jerusalem artichoke acne-removing composition which comprises a jerusalem artichoke extract, a mogrosia macrantha leaf extract and a centella asiatica extract, wherein the mass ratio of the jerusalem artichoke extract to the harleya macrantha leaf extract is (10-15): (1-5): (1-3).
Preferably, the composition comprises jerusalem artichoke extract, motor garland harrenna leaf extract and centella asiatica extract, and the mass ratio of the jerusalem artichoke extract to the motor garland harrenna leaf extract is 10: 3: 2.
preferably, the jerusalem artichoke extract comprises a jerusalem artichoke leaf extract and a jerusalem artichoke tuber extract, and the mass ratio of the jerusalem artichoke leaf extract to the jerusalem artichoke tuber extract is (4-12): (1-3).
Preferably, the jerusalem artichoke leaf extract is prepared by the following method:
oven drying folium Helianthi, pulverizing, sieving, and extracting under reflux to obtain Jerusalem artichoke extract; the extraction reagent is ethanol with the mass fraction of 60-80%, the extraction temperature is 80 ℃, the extraction time is 1-2 h, and the solid-to-liquid ratio is 1: 15-20.
Preferably, the jerusalem artichoke tuber extract is prepared by the following method:
(1) cleaning and peeling fresh jerusalem artichoke tubers, slicing, blanching with hot water, and drying to obtain dry jerusalem artichoke slices;
(2) pulverizing dried slices of Jerusalem artichoke into dry Jerusalem artichoke powder, dissolving in water, performing microwave treatment, adding water, extracting to obtain extractive solution, and rotary evaporating the extractive solution to obtain Jerusalem artichoke tuber extract.
Preferably, the power of the microwave treatment is 300-600w, and the time is 120-300 s; adding water according to the weight ratio of the feed liquid of 1 (14-22) for leaching, wherein the water temperature is 20-100 ℃, and the time is 20-60 min.
Preferably, the content of the asiaticoside in the centella asiatica extract is 70-80%, and the centella asiatica extract is purchased from Shaanxi Baiwei Biotech limited company; the extract of the leaf of Calagagaka Harringiana according to the application number is as follows: 201780024628.7 by the process of the patent.
In a second aspect of the invention, the application of the acne-removing composition in preparing an acne-removing cosmetic is provided.
In a third aspect of the invention, the acne removing cosmetic is provided, and the acne removing composition is used as an effective component.
Preferably, the acne-removing cosmetic comprises an acne-removing facial cleanser, an acne-removing conditioning water, an acne-removing essence and an acne-removing mask.
When preparing the acne-removing facial cleanser, the acne-removing composition can be matched with the following auxiliary materials:
water, glycerol, myristic acid, sodium cocoyl glycinate, sea mud, potassium hydroxide, acrylic acid (ester) copolymer, stearic acid, sodium chloride, cocamidopropyl betaine, lauric acid, sodium methyl cocoyl taurate, ethylene glycol distearate, propylene glycol, potassium lauroyl glutamate, glyceryl stearate SE, cocamide MEA, beeswax, EDTA disodium and essence.
When preparing the acne-removing conditioning water, the acne-removing composition can be added with the following auxiliary materials:
water, 2, 3-butanediol, dipropylene glycol, glycerol, dextrin, levulinic acid, inulin, fructose, sucrose, 1, 2-hexanediol, disodium EDTA, malachite extract, PEG-40 hydrogenated castor oil, and chamomile (Anthemis NOBILIS) flower oil.
When the acne removing essence is prepared, the acne removing composition can be added with the following auxiliary materials:
water, 1, 3-propanediol, cyclopentadecyldimethicone, C20-24 alkyl dimethicone, glyceryl polyether-26, polysiloxane-11, glyceryl glucoside, glycerin, PEG/PPG-17/6 copolymer, erythritol, butylene glycol, lysine, sodium bis (lauramidoglutamine) lysine, polysorbate-60, ammonium acryloyldimethyltaurate/VP copolymer, dextrin, inulin, fructose, sucrose, PHELLODENDRON AMURENSE (PHELLODENDRON AMURENSE) bark extract, abelmoschus caffeicus (HIBISCUS eculentus) fruit extract, surfactin sodium, mica, CI 77491, titanium dioxide, sodium polyacrylate, p-hydroxyacetophenone, disodium EDTA, triethanolamine, PEG-40 hydrogenated castor oil, perfume, CI 16255, CI 42090, CI 17200, CI 19140.
When preparing the acne-removing mask, the acne-removing composition can be matched with the following auxiliary materials:
water, 1, 3-propylene glycol, glycerol, betaine, methyl gluceth-20, cyclopentadimethylsiloxane, polysorbate-60, PEG/PPG-14/7 dimethyl ether, allantoin, arginine ferulate, 1-methylhydantoin-2-imide, Cornus OFFICINALIS (CORNUS OFFICINALIS) extract, p-hydroxyacetophenone, dextrin, inulin, fructose, sucrose, batyl alcohol, polydimethylsiloxane, 1, 2-hexanediol, glyceryl stearate, PEG-100 stearate, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer, xanthan gum, SCLEROTIUM rolfsii (SCLEOTIUM ROLFSSII) gum, sodium hyaluronate, triethanolamine, PEG-40 hydrogenated castor oil, and essence.
The invention has the beneficial effects that:
the acne-removing composition disclosed by the invention takes the jerusalem artichoke extract as a main raw material, the jerusalem artichoke tuber extract and the jerusalem artichoke leaf extract are obtained by processing the jerusalem artichoke tuber and the jerusalem artichoke leaf, and the jerusalem artichoke tuber extract and the jerusalem artichoke leaf extract and the centella asiatica extract are matched to obtain the acne-removing composition which is non-toxic, harmless, safer and quick in effect.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
As described in the background section, the jerusalem artichoke is rich in substances, but the jerusalem artichoke tubers are most commonly used for reducing blood sugar, and the jerusalem artichoke leaves are generally not used for waste. Although the application of the jerusalem artichoke is wide, the report of the application of the jerusalem artichoke to acne removal is not seen. Based on the above, the invention aims to provide the jerusalem artichoke acne removing composition and application thereof. The inventor treats the tubers and leaves of the jerusalem artichoke to obtain the jerusalem artichoke extract, mixes the jerusalem artichoke extract with other plant extracts through the test 1, and performs an acne removing test to finally obtain the acne removing composition.
Test 1
The jerusalem artichoke extract and the acne removing plant are blended according to the mass ratio in the table 1 to obtain a composition, the composition with equal mass is diluted by normal saline to the test concentration of 1% to obtain liquid medicine, then an inhibition zone test is carried out, a paper diffusion method (refer to the Lvjingtian and the like, and the in vitro inhibition experiment research of platelet rich plasma on propionibacterium acnes) is adopted, GAM agar culture medium is improved, autoclaved at 115 ℃ for 15min, then 5% sheep blood is added, and the mixture is poured into a plate culture dish to be used as a recovery plate of freeze-dried strains. Inoculating a propionibacterium acnes freeze-dried strain (ATCC 11827, institute of microorganisms in Guangdong province) into a plate by using a plate marking method, carrying out anaerobic culture at 37 ℃ for 72 hours, and then picking a single growing bacterial colony to an improved GAM broth culture medium to ensure that the concentration of the bacterial body reaches about 5.3-6.5g/L to obtain a bacterial suspension. Heating and melting the modified GAM agar culture medium, sucking the culture medium in an aseptic operation, pouring the culture medium into a plate, and coating 100 mu L of the bacterial suspension on the corresponding plate with the culture medium. Each group was dropped onto a dry and sterilized round filter paper sheet (d ═ 6.0mm), 5 μ L/sheet, with an equal amount of clear water as a control group. Attached to each plate. The sheets were spaced about 24mm apart and about 15mm from the edge of the dish. Plates coated with Propionibacterium acnes were incubated anaerobically at 37 ℃ for 72 h. The zone diameters were measured for 3 replicates of each group and averaged, with the results shown in table 2.
TABLE 1
Table 2 zone of inhibition test results
| Group of | Diameter mm |
| Control group (clear water) | 0 |
| Composition 1 | 21.12 |
| Composition 2 | 21.34 |
| Composition 3 | 19.38 |
| Composition 4 | 19.72 |
| Composition 5 | 19.82 |
| Composition 6 | 19.24 |
As shown in tables 1 and 2, the combination of Jerusalem artichoke extract and Karenia macrantha leaf extract has the best antibacterial effect. Then, the jerusalem artichoke extract, the mogas nervosa leaf extract and other substances or extracts are compounded according to the mixture ratio in the table 3 to obtain each composition, the compositions with equal mass are diluted to the test concentration of 1 percent by using normal saline to obtain liquid medicine, and then the bacteriostatic zone test is carried out. The results are shown in Table 4.
TABLE 3
TABLE 4 zone of inhibition test results
| Group of | Diameter mm |
| Composition 1 | 20.01 |
| Composition 2 | 20.79 |
| Composition 3 | 22.03 |
| Composition 4 | 21.78 |
| Composition 5 | 21.56 |
As can be seen from tables 3 and 4, the bacteriostatic effect was the best when the Jerusalem artichoke extract, the extract of Maka Harpagana leaves and the extract of centella asiatica were compounded.
Note: the preparation method of the leaf extract of the Harenya amalgaricus comprises the following steps:
crushed dry leaves of the motor garragana were extracted with a 50:50(v/v) mixture of ethanol and water. The solution was stirred and heated below 60 ℃ for 1 hour. After removal of the plants, the ethanol extract was decolorized on charcoal. After filtration, the solution was concentrated to obtain an aqueous solution. After settling at 4 ℃ for 12 hours, the solution was filtered. After settling, the extract is filtered and finally lyophilized to obtain the powdered form of the extract, i.e. the mogrosia macragana leaf extract.
The tea tree essential oil is purchased from Jianmin natural spice oil factories in Jishui county;
aloe extract was obtained from Shandong Fengtai Biotech limited;
hamamelis mollis extract was purchased from Saisenann ran bioengineering, Inc.;
chamomile extracts were purchased from sierra bioengineering limited;
calendula extracts were purchased from siennan ran bioengineering, ltd;
the honeysuckle extract is purchased from Xian' jin Cuifang plant technology development Co., Ltd;
the wild chrysanthemum extract is purchased from Ganzhou Baizhentang Biotech Co.
In order to make the technical solutions of the present application more clearly understood by those skilled in the art, the technical solutions of the present application will be described in detail below with reference to specific embodiments.
The test materials used in the examples of the present invention are all conventional in the art and commercially available.
Example 1: preparation of Jerusalem artichoke tuber extract
(1) Fresh jerusalem artichoke is cleaned and subjected to hot water blanching treatment to passivate polyphenol oxidase in the jerusalem artichoke so as to achieve the aim of reducing browning. Then drying to prepare the jerusalem artichoke dry tablets. The temperature of hot water blanching is 90 ℃ and the time is 10 min. The drying temperature for preparing the jerusalem artichoke dry slices is 60 ℃, and the time is 6 hours. The thickness of the slices was 0.2 cm. The water content of the resulting dry tablet was 10%.
(2) The dried jerusalem artichoke slices are crushed into dry jerusalem artichoke powder with 80 meshes. Soaking and dissolving the jerusalem artichoke dry powder in 10 mass times of water, wherein the soaking water is required to be completely dissolved in the jerusalem artichoke dry powder. Then, microwave treatment was carried out at a power of 500w for 200 s. Adding water into the inulin solution after microwave treatment according to the weight ratio of the material liquid of 1:18, and leaching at the water temperature of 80 ℃ for 30min to obtain the jerusalem artichoke tuber extract.
Example 2: preparation of jerusalem artichoke leaf extract
Drying fresh jerusalem artichoke leaves at 60 ℃ until the water content is below 10%, crushing, sieving with a 60-mesh sieve, and performing reflux extraction on sieved jerusalem artichoke leaf powder and 80% alcohol according to the weight ratio of 1: 15; extracting at 80 deg.C for 2 hr to obtain folium Chrysanthemi extract.
Example 3
Taking the jerusalem artichoke leaf extract prepared in the example 2 and the jerusalem artichoke tuber extract prepared in the example 1, and mixing the jerusalem artichoke leaf extract and the jerusalem artichoke tuber extract according to a mass ratio of 8:2 mixing to obtain Jerusalem artichoke extract.
Mixing Jerusalem artichoke extract, Maka-johana leaf extract and centella asiatica extract according to the mass ratio of 10: 3:2 mixing uniformly to obtain the acne-removing composition.
Example 4
Taking the jerusalem artichoke leaf extract prepared in the example 2 and the jerusalem artichoke tuber extract prepared in the example 1, and mixing the jerusalem artichoke leaf extract and the jerusalem artichoke tuber extract according to a mass ratio of 8:2 mixing to obtain Jerusalem artichoke extract.
Mixing Jerusalem artichoke extract, Maka-johana leaf extract and centella asiatica extract according to the mass ratio of 15: 5: 1, uniformly mixing to obtain the acne-removing composition.
Example 5
Taking the jerusalem artichoke leaf extract prepared in the example 2 and the jerusalem artichoke tuber extract prepared in the example 1, and mixing the extract according to the mass ratio (4-12): (1-3) mixing to obtain the jerusalem artichoke extract.
Mixing Jerusalem artichoke extract, Maka-johana leaf extract and centella asiatica extract according to the mass ratio of 15: 3: 3 mixing uniformly to obtain the acne-removing composition.
Comparative example 1
Taking the jerusalem artichoke leaf extract prepared in the example 2 and the jerusalem artichoke tuber extract prepared in the example 1, and mixing the jerusalem artichoke leaf extract and the jerusalem artichoke tuber extract according to a mass ratio of 2: 8 mixing to obtain Jerusalem artichoke extract.
Mixing Jerusalem artichoke extract, Maka-johana leaf extract and centella asiatica extract according to the mass ratio of 10: 3:2 mixing uniformly to obtain the acne-removing composition.
Comparative example 2
Uniformly mixing chlorogenic acid, inulin, a madagascar hamarta leaf extract and a centella asiatica extract according to a mass ratio of 8:2:3:2 to obtain the acne-removing composition.
Comparative example 3
The jerusalem artichoke leaf extract, the mogrosia mackerel leaf extract and the centella asiatica extract prepared in example 2 are mixed according to a mass ratio of 10: 3:2 mixing uniformly to obtain the acne-removing composition.
Comparative example 4
The jerusalem artichoke tuber extract, the mogas nervosa leaf extract and the centella asiatica extract prepared in example 1 are mixed according to the mass ratio of 10: 3:2 mixing uniformly to obtain the acne-removing composition.
Comparative example 5
Mixing a leaf extract of Gaussa harrenana and a centella asiatica extract according to a mass ratio of 3:2 mixing uniformly to obtain the acne-removing composition.
Test example 1 evaluation of safety of product (test of patch on skin)
Test products: the acne-removing compositions prepared in examples 3-5 and comparative examples 1-5;
number of test population: 160 persons, male and female halves; age: between 12 and 25 years old; health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject. Grouping: 8 groups of 20 persons each, mean age 18.6 years.
The spot pasting method comprises the following steps: selecting a qualified spot tester, dripping 0.020 g-0.025 g of a tested object into the spot tester in a closed spot patch test mode, externally applying a special adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after the tested object is removed respectively, and recording the results according to the skin reaction grading standard in the cosmetic hygiene standard.
The experimental results are as follows: the result of the human body skin patch test shows that: each group of subjects pass the patch test of the acne-removing composition prepared in examples 3-5 and comparative examples 1-5, and observe skin reactions at 0.5, 6, 12, 24 and 48 hours, wherein 0 case has adverse skin reactions, which indicates that the acne-removing composition is safe to use.
Experimental example 2 cases of acne treatment
Case selection: mainly occurs in the developed parts of sebaceous glands of face, mandible, forehead, upper chest and back, and the skin lesion is acne, inflammatory papule, pustule, nodule, accompanied with seborrhea and acne repeatedly. The number of the test persons was 160, and the test persons were divided into 8 groups of 20 persons. The acne removing compositions prepared in the examples 3-5 and the comparative examples 1-5 are prepared into an aqueous solution with the mass percentage of 1% and applied to the affected part for 2 times per day. Spicy, high-protein, high-fat and high-sugar foods are prohibited during coating. The test results are shown in Table 5.
Criteria for effect determination
The basic cure is as follows: the total skin damage before and after treatment is reduced by more than or equal to 90 percent;
the effect is shown: the total number of skin lesions before and after treatment is reduced by 60 to 89 percent;
the method has the following advantages: the total number of skin lesions before and after treatment is reduced by 20 to 59 percent;
and (4) invalidation: the total skin damage before and after treatment is reduced by less than 20 percent;
total effective rate (cure + significant effect + effective)/total number of cases x 100%.
TABLE 5 Effect
| Group of | Basic healing | Show effect | Is effective | Invalidation | The total effective rate% |
| Example 3 | 15 | 3 | 2 | 0 | 100 |
| Example 4 | 15 | 2 | 2 | 1 | 95 |
| Example 5 | 15 | 1 | 3 | 1 | 95 |
| Comparative example 1 | 10 | 4 | 2 | 4 | 80 |
| Comparative example 2 | 13 | 1 | 2 | 4 | 80 |
| Comparative example 3 | 11 | 5 | 1 | 3 | 85 |
| Comparative example 4 | 10 | 3 | 2 | 5 | 75 |
| Comparative example 5 | 10 | 1 | 3 | 6 | 70 |
As can be seen from table 2, the acne-removing composition of the present invention has significant effects in treating acne of patients, the total effective rate is up to 95% or more, most of the acne of patients gradually disappear and are cured, and the curative effect is significant.
Test example 3 in vitro test for enhancing the Activity of human epidermal keratinocytes
The method comprises the steps of taking a 96-well plate, adding 1000 human epidermal keratinocytes into each well, culturing the plate by adopting a serum-free culture solution (purchased from Life technologies), changing the culture solution once every 3 days, adding the acne-removing compositions prepared in the examples 3-5 and the comparative examples 1-5 respectively after the cells are attached to prepare aqueous solutions with the mass fraction of 1%, culturing the aqueous solutions by 10 mu L each group for 96 hours, measuring the consumption of glucose to represent the activity of aged cells, and testing results are shown in Table 6.
TABLE 6
| Group of | Increase rate of cell viability% |
| Example 3 | 156.45 |
| Example 4 | 151.22 |
| Example 5 | 152.46 |
| Comparative example 1 | 132.89 |
| Comparative example 2 | 138.66 |
| Comparative example 3 | 144.98 |
| Comparative example 4 | 129.66 |
| Comparative example 5 | 127.01 |
Note: each group was tested 3 times and the average was taken.
As can be seen from table 6, the acne-removing composition of the present invention has a significant effect of increasing the activity of human epidermal keratinocytes. Effectively promote the repair of the damaged skin.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. The jerusalem artichoke acne removing composition is characterized in that: the composition comprises a jerusalem artichoke extract, a mogrosia mackerel leaf extract and a centella asiatica extract, and the mass ratio of the jerusalem artichoke extract to the mogrosia mackerel leaf extract is (10-15): (1-5): (1-3).
2. The jerusalem artichoke acne-removing composition according to claim 1, which is characterized in that: comprises jerusalem artichoke extract, mogas nervosa leaf extract and centella asiatica extract, and the mass ratio of the jerusalem artichoke extract to the mogas nervosa leaf extract is 10: 3: 2.
3. the jerusalem artichoke acne-removing composition according to claim 1 or 2, characterized in that: the jerusalem artichoke extract comprises a jerusalem artichoke leaf extract and a jerusalem artichoke tuber extract, and the mass ratio of the jerusalem artichoke leaf extract to the jerusalem artichoke tuber extract is (4-12): (1-3).
4. The jerusalem artichoke acne removal composition according to claim 3, wherein: the jerusalem artichoke leaf extract is prepared by the following method:
oven drying folium Helianthi, pulverizing, sieving, and extracting under reflux to obtain Jerusalem artichoke extract; the extraction reagent is ethanol with the mass fraction of 60-80%, the extraction temperature is 80 ℃, the extraction time is 1-2 h, and the solid-to-liquid ratio is 1: 15-20.
5. The jerusalem artichoke acne removal composition according to claim 3, wherein: the jerusalem artichoke tuber extract is prepared by the following method:
(1) cleaning and peeling fresh jerusalem artichoke tubers, slicing, blanching with hot water, and drying to obtain dry jerusalem artichoke slices;
(2) pulverizing dried slices of Jerusalem artichoke into dry Jerusalem artichoke powder, dissolving in water, performing microwave treatment, adding water, extracting to obtain extractive solution, and rotary evaporating the extractive solution to obtain Jerusalem artichoke tuber extract.
6. The jerusalem artichoke acne removal composition according to claim 5, wherein: the power of the microwave treatment is 300-600w, and the time is 120-300 s; adding water according to the weight ratio of the feed liquid of 1 (14-22) for leaching, wherein the water temperature is 20-100 ℃, and the time is 20-60 min.
7. The jerusalem artichoke acne-removing composition according to claim 1, which is characterized in that: the centella asiatica extract contains 70-80% of total asiaticoside, and is purchased from Shaanxi Baiwei Biotech limited; the extract of the leaf of Calagagaka Harringiana according to the application number is as follows: 201780024628.7 by the process of the patent.
8. Use of the acne-removing composition according to any one of claims 1-7 in the preparation of an acne-removing cosmetic.
9. An acne-removing cosmetic is characterized in that: the acne-removing composition according to any one of claims 1 to 7 as an active ingredient.
10. The anti-acne cosmetic of claim 9, wherein: the acne-removing cosmetic comprises an acne-removing facial cleanser, an acne-removing conditioning water, an acne-removing essence and an acne-removing mask.
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| CN113143817B (en) | 2023-06-20 |
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